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COPD cardiac rehabilitation

Masamichi Sato, Sumito Inoue, Akira Igarashi, Yoshikane Tokairin, Kento Sato, Hiroshi Nakano, Yuki Abe, Maki Kobayashi, Tomomi Kimura, Keiko Yamauchi, Michiko Nishiwaki, Yukihiro Minegishi, Sujeong Yang, Kodai Furuyama, Tomoka Yamamoto, Hiroyoshi Machida, Yoko Shibata
BACKGROUND: The designation of some cardiac-specific proteins as prognostic biomarkers in chronic obstructive pulmonary disease (COPD) exacerbations suggest that the process of exacerbation involves cardiomyocyte injury. Among these cardiac biomarkers, heart-type fatty acid binding protein (h-FABP) is considered a very sensitive diagnostic marker for cardiomyocyte injury and a prognostic marker in chronic heart failure. However, the prognostic usefulness of h-FABP in patients with COPD remains unclear...
March 2018: Respiratory Investigation
Jibril Mohammed, Eric Derom, Tine De Backer, Inge De Wandele, Patrick Calders
Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated...
February 2018: COPD
Guillaume Prieur, Clement Medrinal, Yann Combret, Aurora Robledo Quesada, Fabrice Prieur, Jean Quieffin, Jean Christian Borel, Gregory Reychler
INTRODUCTION: Early pulmonary rehabilitation is recommended after a severe exacerbation of chronic obstructive pulmonary disease (COPD). However, this is difficult to implement, particularly for exercise training. High-flow nasal therapy (HFNT) may reduce the work of breathing and dyspnoea and may improve exercise tolerance. METHODS AND ANALYSIS: This is a single-centre, prospective, controlled, randomised, cross-over study. Eligible patients will have a diagnosis of COPD (postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio of <0...
2017: BMJ Open Respiratory Research
C A Sima, J A Inskip, A W Sheel, S F van Eeden, W D Reid, P G Camp
BACKGROUND: Reduced heart rate variability (HRV), a marker of autonomic system dysfunction, has been reported in patients with chronic obstructive pulmonary disease (COPD). Yet, limited data exists on the reliability of HRV measurement in this population. Here we investigated the reliability of short-term HRV measurement performed during spontaneous breathing in patients with COPD. METHODS: Thirteen individuals (8 males) with moderate-to-severe COPD (FEV1 46±16% predicted; FEV1 /FVC 49±13) underwent standard time and frequency domain HRV measurements derived from 5-minute electrocardiograms collected on two separate days using a SphygmoCor device...
November 2017: Revista Portuguesa de Pneumologia
Adriana Mazzuco, Wladimir Musetti Medeiros, Aline Soares de Souza, Maria Clara Noman Alencar, José Alberto Neder, Audrey Borghi-Silva
BACKGROUND: Poor exercise capacity is an important negative prognostic marker in patients with chronic obstructive pulmonary disease (COPD). Heart rate variability (HRV) responses can indicate alterations in cardiac autonomic control. Nevertheless, it remains unclear whether these abnormalities are related to cardiorespiratory responses to exercise in these patients. OBJECTIVE: To evaluate whether HRV at rest and submaximal exercise are related to impaired cardiopulmonary responses to exercise in COPD patients...
July 2017: Brazilian Journal of Physical Therapy
Keisuke Miki, Ryoji Maekura, Seigo Kitada, Mari Miki, Kenji Yoshimura, Hiroshi Yamamoto, Toshiko Kawabe, Hiroyuki Kagawa, Yohei Oshitani, Akitoshi Satomi, Kohei Nishida, Nobuhiko Sawa, Kimiko Inoue
BACKGROUND: COPD patients undergoing pulmonary rehabilitation (PR) show various responses. The purpose of this study was to investigate the possible mechanisms and predictors of the response to PR in COPD patients. METHODS: Thirty-six stable COPD patients underwent PR including a 4-week high-intensity exercise training program, and they were evaluated by cardiopulmonary exercise testing. All patients (mean age 69 years, severe and very severe COPD 94%) were classified into four groups by whether the exercise time (Tex) or the peak oxygen uptake [Formula: see text] increased after PR: two factors increased (both the Tex and the peak [Formula: see text] increased); two factors decreased; time only increased (the Tex increased, but the peak [Formula: see text] economized); and [Formula: see text] only increased (the Tex decreased, but the peak [Formula: see text] increased)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
Pichapong Tunsupon, Ashima Lal, Mohammed Abo Khamis, M Jeffery Mador
PURPOSE: The objective of this study was to evaluate the impact of comorbidities as potential predictors of the response to pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). METHODS: The study included 165 patients with COPD with exercise limitations. Comorbidity was classified as cardiac, metabolic, orthopedic, behavioral health problems, or other diseases. Number of comorbidities was grouped as 0, 1, or ≥2. Outcomes were defined as improvement in exercise capacity (maximal exercise capacity, 6-minute walk test, and constant workload cycle exercise duration) and quality of life (Chronic Respiratory Questionnaire)...
April 12, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
Atsuhito Nakazawa, Narelle S Cox, Anne E Holland
Interstitial lung disease (ILD) is a group of chronic respiratory diseases characterized by dyspnoea on exertion and decline in health-related quality of life (HRQL). People with ILD experience significant exercise limitation with contributors that include ventilatory limitation, impaired gas exchange, decreased cardiac function and skeletal muscle dysfunction. Pulmonary rehabilitation (PR) is well established in patients with chronic obstructive pulmonary disease (COPD) as a means to overcome exercise limitation and improve activity-related dyspnoea...
February 2017: Therapeutic Advances in Respiratory Disease
Sarah Houben-Wilke, Martijn A Spruit, Nicole H M K Uszko-Lencer, Gosia Otkinska, Lowie E G W Vanfleteren, Paul W Jones, Emiel F M Wouters, Frits M E Franssen
BACKGROUND AND OBJECTIVE: Both patients with cardiac diseases as well as those with COPD report an impaired health status. The frequencies of objectively assessed co-morbid cardiac diseases and their impact on health status in patients with COPD are unknown. We aimed to investigate echocardiographic abnormalities and their impact on health status in a large cohort of patients with COPD referred for pulmonary rehabilitation (PR). METHODS: In this cross-sectional, observational analyses, demographic and clinical characteristics were assessed during an inpatient pre-PR assessment...
July 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
Anke Neukamm, Gunnar Einvik, Arne Didrik Høiseth, Vidar Søyseth, Nils Henrik Holmedahl, Natalia Kononova, Torbjørn Omland
BACKGROUND: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD). Cardiac troponin (cTn) elevation, indicating myocardial injury, is frequent during acute COPD exacerbations and associated with increased mortality. The prognostic value of circulating cTnT among COPD patients in the stable state of the disease is still unknown. The purpose of the present study was to assess the association between circulating cTnT measured by a high sensitive assay (hs-cTnT) and all-cause mortality among patients with stable COPD without overt CVD...
November 25, 2016: BMC Pulmonary Medicine
Clément Medrinal, Guillaume Prieur, David Debeaumont, Aurora Robledo Quesada, Yann Combret, Jean Quieffin, Olivier Contal, Bouchra Lamia
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) has systemic repercussions that can lead to peripheral muscle dysfunction. Muscle atrophy reduces aerobic capacity, greatly limiting activities of daily living and quality of life. Pulmonary rehabilitation is the gold standard treatment for these patients, however, patients may not be able to reach sufficient training intensities for benefits to occur. Technologies such as functional electrical stimulation (FES) are currently being adapted and tested to enhance exercise training...
2016: BMJ Open Respiratory Research
Filip Jj Triest, Sally J Singh, Lowie Egw Vanfleteren
Patients with chronic obstructive pulmonary disease (COPD) who participate in pulmonary rehabilitation (PR) often have concomitant cardiovascular disease (CVD), which is a frequently undiagnosed and undertreated comorbidity. CVD contributes to the burden of the disease and is associated with an increased risk for hospitalizations and mortality. Optimizing the diagnosis and management of cardiovascular risk and disease should be considered as part of the holistic approach of PR. In addition, we need to consider similarities and differences in cardiac and PR programs, in order to improve personalized care in patients with both diseases...
August 2016: Chronic Respiratory Disease
William D-C Man, Faiza Chowdhury, Rod S Taylor, Rachael A Evans, Patrick Doherty, Sally J Singh, Sara Booth, Davey Thomason, Debbie Andrews, Cassie Lee, Jackie Hanna, Michael D Morgan, Derek Bell, Martin R Cowie
The study aimed to gain consensus on key priorities for developing breathlessness rehabilitation services for patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). Seventy-four invited stakeholders attended a 1-day conference to review the evidence base for exercise-based rehabilitation in COPD and CHF. In addition, 47 recorded their views on a series of statements regarding breathlessness rehabilitation tailored to the needs of both patient groups. A total of 75% of stakeholders supported symptom-based rather than disease-based rehabilitation for breathlessness with 89% believing that such services would be attractive for healthcare commissioners...
August 2016: Chronic Respiratory Disease
Keisuke Miki, Ryoji Maekura, Masamitsu Nakazato, Nobuhiro Matsumoto, Seigo Kitada, Mari Miki, Kenji Yoshimura, Masahide Mori, Kenji Kangawa
OBJECTIVES: Ghrelin, a growth hormone-releasing peptide, has shown efficacy in chronic obstructive pulmonary disease (COPD) patients in previous trials. This study was designed to evaluate the effective dose of ghrelin in chronic respiratory failure patients. METHODS: In this randomized, double-blind, dose-finding, single-center study, 18 patients, including 16 with COPD, were randomly assigned to receive pulmonary rehabilitation (PR) with intravenous ghrelin at 1 μg/kg or 2 μg/kg, twice daily for 3 weeks...
August 10, 2015: Clinical Respiratory Journal
Catarina Santos, Fátima Rodrigues, Joana Santos, Luísa Morais, Cristina Bárbara
BACKGROUND: Exercise training is an important component of pulmonary rehabilitation, but it remains questionable how training intensity affects patient-centered outcomes. The aim of this study was to compare the effects of 2 aerobic training intensities on health-related quality of life (HRQOL), symptom control, and exercise tolerance in subjects with COPD. METHODS: Thirty-four subjects with mild to very severe COPD participated in an equivalence/non-inferiority randomized controlled trial with a parallel group blinded to 60 or 80% maximum work rate (W max) aerobic training intensity...
November 2015: Respiratory Care
I Nasis, E Kortianou, Μ Vasilopoulou, S Spetsioti, Z Louvaris, G Kaltsakas, C H Davos, S Zakynthinos, N G Koulouris, I Vogiatzis
Dynamic hyperinflation (DH) has a significant adverse effect on cardiovascular function during exercise in COPD patients. COPD patients with (n = 25) and without (n = 11) exercise-induced DH undertook an incremental (IET) and a constant-load exercise test (CLET) sustained at 75% peak work (WRpeak) prior to and following an interval cycling exercise training regime (set at 100% WRpeak with 30-s work/30-s rest intervals) lasting for 12 weeks. Cardiac output (Q) was assessed by cardio-bio-impedance (PhysioFlow, enduro, PF-O7) to determine Q mean response time (QMRT) at onset (QMRT(ON)) and offset (QMRT(OFF)) of CLET...
October 2015: Respiratory Physiology & Neurobiology
Francesco Giallauria, Francesco Fattirolli, Roberto Tramarin, Marco Ambrosetti, Raffaele Griffo, Carmine Riccio, Stefania De Feo, Massimo Francesco Piepoli, Carlo Vigorito
BACKGROUND: Using data from the Italian SurveY on carDiac rEhabilitation (ISYDE-2008), this study provides insight into the level of implementation of Cardiac Rehabilitation (CR) in patients with diabetes. METHODS: Data from 165 CR units were collected online from January 28th to February 10th, 2008. RESULTS: The study cohort consisted of 2281 patients (66.9 ± 12 yrs); 475 (69.7 ± 10 yrs, 74% male) patients with diabetes and 1806 (66.2 ± 12 yrs, 72% male) non-diabetic patients...
February 2015: Diabetes Research and Clinical Practice
M Dahdah, S Barnes, K Schmidt, A Buros, R Dubiel, C Dunklin, L Callender, S Shafi
OBJECTIVE: To determine the impact of preexisting illness on inpatient rehabilitation outcomes in patients with TBI. METHOD: Retrospective analysis of prospectively collected data from a TBI Model System Center, inpatient rehabilitation center. Participants included 132 TBI survivors aged ≥ 16. OUTCOME MEASURES: FIM total score and DRS at discharge, Trail Making Test A (TMT: A), Trail Making Test B (TMT: B), and Total Trials 1-5 of California Verbal Learning Test, 2nd Edition (CVLT-II)...
September 2014: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Maureen Davey, Wendy Moore, Julia Walters
BACKGROUND: Although the burden of cardiopulmonary diseases in the Aboriginal community is high, utilisation of rehabilitation services has been poor. We evaluated the uptake and effectiveness of a cardiovascular and pulmonary rehabilitation program specifically designed and provided for the Aboriginal community, by the Tasmanian Aboriginal Centre, for people with diagnosed chronic heart or respiratory disease and those at high risk of developing such conditions. METHODS: Participants had established chronic obstructive pulmonary disease, ischaemic heart disease or chronic heart failure or were at high risk of developing such diseases because of multiple risk factors...
2014: BMC Health Services Research
Alexandra Marie Nanzer, John Janssen, Matthew Hind
A 78-year-old man presented with severe exertional dyspnoea. He suffered from mild chronic obstructive pulmonary disease, congestive cardiac failure and seropositive myasthaenia gravis. Clinical examination of his chest and heart were unremarkable but he had speech dyspnoea and was unable to count to 20 in a single breath. Consecutive sniff nasal inspiratory measurements (SNIP) fell from 55 to 33 cm H2O and forced vital capacity (FVC) fell from 3.4 to 2.4 L. A diagnosis of myasthenic crisis was carried out and treatment with non-invasive ventilation, intravenous immunoglobulis and high-dose oral prednisolone was initiated...
2014: BMJ Case Reports
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