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Emily Y Y Chan, Holly C Y Lam, Suzanne H W So, William B Goggins, Janice Y Ho, Sida Liu, Phoebe P W Chung
Background : Mental disorders have been found to be positively associated with temperature in cool to cold climatic regions but the association in warmer regions is unclear. This study presented the short-term association between temperatures and mental disorder hospitalizations in a subtropical city with a mean annual temperature over 21 °C. Methods : Using Poisson-generalized additive models and distributed-lagged nonlinear models, daily mental disorder hospitalizations between 2002 and 2011 in Hong Kong were regressed on daily mean temperature, relative humidity, and air pollutants, adjusted for seasonal trend, long-term trend, day-of-week, and holiday...
April 14, 2018: International Journal of Environmental Research and Public Health
Sida Xing, Svyatoslav Kharitonov, Jianqi Hu, Camille-Sophie Brès
We observe fiber fuse in tapered GeAsSe photonic crystal fibers (PCF) at around 7  MW/cm2 of intra-core intensity. Vertically cleaved facets from the un-tapered regions and the tapered regions were imaged. The images show shallow voids of different shapes confined to the fiber core. After longitudinally polishing a segment of the PCF, we imaged the PCF internal structure's top view, revealing the fuse voids' geometries and periodicity. In addition, fiber fuse was terminated in one PCF sample by a fast laser shutdown, hence saving a small segment from catastrophic damage...
April 1, 2018: Optics Letters
Hina Firdous, Talib Hussain, Monika Singh, Syed Mohd Danish Rizvi, Afrasim Moin, Mohammad A Kamal
Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri, Pecan nut, Allium cepa, Beta Vulgaris, Adina cordifolia, Ocimum gratissimum, Vernonia amygdalina, Sida veronicaefolia, Chenopodium album, Korean red ginseng, Elephantopus scaber, Tecomella undulata, Prunus armeniaca, Sea tangle (Laminaria japonica), Emblica officinalis, Saccharum officinarum, Cocculus hirsutus, Cassia roxburghii, Zhi-Zi-Da-Huang, Phyllanthus amarus, Aegle marmelos, Agrimonia eupatoria, Flaveria trinervia, Curcuma longa and Garcinia indica...
March 30, 2018: Current Drug Metabolism
Monika Kosowska, Małgorzata Majcher, Henryk H Jelen, Teresa Fortuna
Smoked cooked loin is one of the most popular meat products in Poland. In this study, key volatile compounds in this traditional Polish meat product were determined using gas chromatography - olfactometry and aroma extract dilution analysis (AEDA). In total, 27 odor-active volatile compounds were identified with flavor dilution factors (FD) ranging from 4 to 1024, and the highest ones noted for 2-methoxyphenol, 2-methoxy-4-(prop-2-enyl)phenol, and 2-methoxy-4-(E)-(prop-1-en-1-yl)phenol . Results of the quantitative analyses, based on determinations with stable isotope dilution assays (SIDA) and standard addition (SA), followed by calculations of the odor activity value (OAV) enabled identifying 24 of the volatile compounds responsible for flavor development in the analyzed smoked cooked loin...
March 24, 2018: Journal of Agricultural and Food Chemistry
Fusheng Zhou, Liang Zhang, Yunzhou Jin, Wei Liu, Pengfei Cheng, Xiangyu He, Jing Xie, Sida Shen, Jing Lei, Haixia Ji, Yi Hu, Yingtao Liu, Yumin Cui, Qiang Lv, Jiong Lan
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the EGFR L858R/T790M. The most representative compound 28 showed high activity against EGFR L858R/T790M kinase (IC50  = 4 nM) and 22-fold selectivity against wild type EGFR. Moreover, compound 28 potently inhibited EGFR L858R/T790M phosphorylation (IC50  = 41 nM) and cellular proliferation (IC50  = 37 nM) in the H1975 cell line, while being significantly less toxic to A431 cells...
December 6, 2017: Bioorganic & Medicinal Chemistry Letters
Rainer Schmitt, Michael Cappi, Gwendola Pollner, Veronika Greger
An aroma extract dilution analysis (AEDA) applied on aroma extracts prepared from the edible flower Dushi Button ( Lippia dulcis) resulted in the detection of 34 odor-active compounds. The highest flavor dilution (FD) factors were determined for methyl 2-methylbutanoate, ethyl 2-methylbutanoate, 4-mercapto-4-methyl-2-pentanone, an unknown caramel-like compound, and vanillin. Quantitative measurements performed by application of stable isotope dilution assays (SIDA), followed by a calculation of odor activity values (OAVs), resulted in the revelation of 4-mercapto-4-methyl-2-pentanone, linalool, myrcene, ethyl 2-methylbutanoate, methyl 2-methylbutanoate, and ( Z)-3-hexenal as important contributors to the flavor of Dushi Buttons...
March 14, 2018: Journal of Agricultural and Food Chemistry
Nayereh Ghods, Mehraban Falahati, Maryam Roudbary, Shirin Farahyar, Masoud Shamaei, Mahin Pourabdollah, Farhad Seif
The virulence genes in invasive aspergillosis (IA) have not been analyzed adequately. The present study was designed to evaluate the expression of gpaB and sidA genes, which are important virulence genes in Aspergillus spp. from bronchoalveolar lavage (BAL) samples. Direct examination and culture on Czapek Agar and Sabouraud Dextrose Agar media were performed for 600 BAL specimens isolated from patients with possible aspergillosis. A Galactomannan ELISA assay was also carried out. The expression levels of the gpaB and sidA genes in isolates were analyzed using quantitative real-time PCR (qRT-PCR)...
February 3, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Loes A M Leenen, Ben F M Wijnen, Alfons G H Kessels, HoiYau Chan, Reina J A de Kinderen, Silvia M A A Evers, Caroline M van Heugten, Marian H J M Majoie
BACKGROUND: The objective of the ZMILE study was to compare the effectiveness of a multicomponent self-management intervention (MCI) with care as usual (CAU) in adult patients with epilepsy (PWE) over a six-month period. METHODS: Participants (PWE & relative) were randomized into intervention or CAU groups. Self-report questionnaires were used to measure disease-specific self-efficacy as the primary outcome measure and general self-efficacy, adherence, seizure severity, emotional functioning, quality of life, proactive coping, and side-effects of antiepileptic drugs (AED) as secondary outcome measures...
February 12, 2018: Epilepsy & Behavior: E&B
Gang Li, Sida Qin, Xin Sun, Jiansheng Wang, Yunfeng Zhang, Jia Zhang, Jing Zhang, Shou-Ching Tang, Hong Ren
The method of suturing for incisions is crucial for the comprehensive treatment of clinical patients with breast cancer. Suturing is considered a major part of post-surgical recovery and may serve as a marker for evaluation of surgical outcome. The present study aimed to establish an effective means of suturing for patients who received modified radical surgery that helps to improve the cosmetic outcome of the incision. Enrolled patients were divided into an active and a control group. Ti-Ni memory alloy wire for intradermal suture in the active group and silk for interruption suture in the control group were applied to assess the different prognosis-associated factors...
February 2018: Oncology Letters
Allison K Stewart, Wendy K Strangman, Andrew Percy, Jeffrey L C Wright
The global need for accurate and sensitive quantitation of microcystins (MCs) persists as incidents of cyanobacterial harmful algal blooms continue to rise and recent research reveals an underestimation of the human health implications of these toxins. An optimal approach for their accurate quantitation relies on the availability of stable isotope-labeled MC standards for use in stable isotope dilution analysis (SIDA) strategies involving liquid chromatography tandem mass spectrometry (LC-MS/MS). Due to the dearth of isotopically labeled MCs, ten different 15N-enriched MCs were biosynthesized from producing cultures and fully characterized...
February 7, 2018: Toxicon: Official Journal of the International Society on Toxinology
Guanghong Huang, Xin Sun, Dapeng Liu, Yunfeng Zhang, Boxiang Zhang, Guodong Xiao, Xiang Li, Xiao Gao, Chenhao Hu, Meng Wang, Hong Ren, Sida Qin
Antibodies against the immune checkpoint proteins PD-1 and PD-L1 are novel therapeutic drugs for the treatment of advanced non-small cell lung cancer (NSCLC). Many clinical trials involving these drugs achieved breakthroughs in patients previously treated for advanced NSCLC. However, the results of these clinical studies are not consistent. In this report, we performed a meta-analysis to assess the efficacy and safety of anti-PD-1/PD-L1 antibodies compared with docetaxel treatment for advanced NSCLC patients from 5 randomized clinical trials...
January 9, 2018: Oncotarget
Hemerson S da Rosa, Mariana Koetz, Marí Castro Santos, Elisa Helena Farias Jandrey, Vanderlei Folmer, Amélia Teresinha Henriques, Andreas Sebastian Loureiro Mendez
Sida tuberculata (ST) is a Malvaceae species widely distributed in Southern Brazil. In traditional medicine, ST has been employed as hypoglycemic, hypocholesterolemic, anti-inflammatory and antimicrobial. Additionally, this species is chemically characterized by flavonoids, alkaloids and phytoecdysteroids mainly. The present work aimed to optimize the extractive technique and to validate an UHPLC method for the determination of 20-hydroxyecdsone (20HE) in the ST leaves. Box-Behnken Design (BBD) was used in method optimization...
February 3, 2018: Steroids
Muhammad Idrees, Saima Batool, Tanzila Kalsoom, Sadaf Raina, Hafiz Muhammad Adeel Sharif, Summera Yasmeen
Nanotechnology exhibits a unique multidisciplinary area and gained fame and interests for researchers. Nanoparticles produced via physical and chemical methods effects ecosystem drastically. Researches trying to implement eco-friendly ways to overcome this issue. Green synthesis is a most attractive and charming technique inexpensive, simple and safe for environment. This study aimed to explore the anti-bacterial actions of as-synthesized silver nanoparticles (Ag-NPs) against Escherichia coli, Staphylococcus aureus and Streptococcus faecalis...
February 1, 2018: Environmental Technology
Greta Tam, Emily Ying Yang Chan, Sida Liu
BACKGROUND: Web-based public health courses are becoming increasingly popular. "Public Health Principles in Disaster and Medical Humanitarian Response" is a unique Web-based course in Hong Kong. This course aimed to fill a public health training gap by reaching out to postgraduates who are unable to access face-to-face learning. OBJECTIVE: The aim of this paper was to use a structured framework to objectively evaluate the effectiveness of a Web-based course according to Greenhalgh et al's quality framework and the Donabedian model to make recommendations for program improvement...
January 26, 2018: JMIR Medical Education
Weimin Xuan, Daniel Collins, Minseob Koh, Sida Shao, Anzhi Yao, Han Xiao, Philip Garner, Peter G Schultz
Here, we report the site-specific incorporation of a thioester containing noncanonical amino acid (ncAA) into recombinantly expressed proteins. Specifically, we genetically encoded a thioester-activated aspartic acid (ThioD) in bacteria in good yield and with high fidelity using an orthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair. To demonstrate the utility of ThioD, we used native chemical ligation to label green fluorescent protein with a fluorophore in good yield.
March 16, 2018: ACS Chemical Biology
Jason D Guffey, Curtis E Haas, Amber Crowley, Kathryn A Connor, David C Kaufman
BACKGROUND: Older reports of use of hydrochloric acid (HCl) infusions for treatment of metabolic alkalosis document variable dosing strategies and risk. OBJECTIVES: This study sought to characterize use of HCl infusions in surgical intensive care unit patients for the treatment of metabolic alkalosis. METHODS: This retrospective review included patients who received a HCl infusion for >8 hours. The primary end point was to evaluate the utility of common acid-base equations for predicting HCl dose requirements...
January 1, 2018: Annals of Pharmacotherapy
Nina Duhamel, Davide Slaghenaufi, Lisa I Pilkington, Mandy Herbst-Johnstone, Roberto Larcher, David Barker, Bruno Fedrizzi
Sesquiterpenes are a widespread class of compounds of increasing interest found in grapes and wines, amongst many other natural sources. Due to a lack of standards and the complexity of the mass spectra fragmentation, accurate quantification of these low concentration compounds had not previously been accomplished. The current paper presents a new method for the concurrent quantification of several sesquiterpenes. The multivariate method optimisation is presented. Synthesised isotopic standards were utilised in conjunction with solid phase microextraction (SPME) and gas chromatography-tandem mass spectrometry (GC-MS/MS) to perform a standard isotope dilution assay (SIDA)...
February 16, 2018: Journal of Chromatography. A
Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou-Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren, Dapeng Liu
Let-7 microRNAs have been reported to have tumor suppressive functions; however, the effect of Let-7 when used in combination with chemotherapies is uncertain, but may have potential for use in clinical practice. In this study, we used RT-qPCR, western blot analysis, cell proliferation assay, flow cytometry analysis, immunohistochemistry (IHC) staining, luciferase assays, cell sorting analysis and xenografted tumor model to explore the role of Let-7 in the chemotherapy sensitivity of breast cancer stem cells...
April 2018: International Journal of Molecular Medicine
Yutian Peng, Hua Zhang, Min Xu, Man-Wah Tan
Aspergillus fumigatus is one of the major causes of invasive pulmonary aspergillosis in immunocompromised patients. Novel antifungal therapy is in urgent need due to emerging resistance and adverse toxicity of current antifungal drugs. Gene products that are essential for Aspergillus viability during infection are attractive drug targets. To characterize these genes in vivo we developed a Tet-Off gene expression system in A. fumigatus, whereby the administration of doxycycline resulted in down regulation of the gene whose expression is under the control of the Tet-Off promoter...
January 11, 2018: Scientific Reports
Jincheng Li, Huan Liu, Chaoying Wang, Jien Yang, Gang Han
BACKGROUND: Methyleugenol is a common phenylpropanoid compound found in many plants and has been widely used as a flavoring agent in people's daily life. In this study, a stable isotope dilution assay-coupled gas chromatography/triple quadrupole mass spectrometry (SIDA-GC/MS/MS) method was developed for the quantitative determination of methyleugenol in food samples. Methyleugenol-D3 was synthesized and used as an isotope internal standard for the determination of methyleugenol. The QuEChERS (quick, easy, cheap, effective, rugged and safe) method was applied to the clean-up of food sample extracts...
January 4, 2018: Journal of the Science of Food and Agriculture
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