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https://www.readbyqxmd.com/read/28167974/preventive-effects-of-a-chinese-herbal-formula-shengjiang-xiexin-decoction-on-irinotecan-induced-delayed-onset-diarrhea-in-rats
#1
Chao Deng, Bo Deng, Liqun Jia, Huangying Tan, Pan Zhang, Sida Liu, Yanan Zhang, Aiping Song, Lin Pan
Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28167502/a-genetic-interaction-analysis-identifies-cancer-drivers-that-modify-egfr-dependency
#2
Sida Liao, Teresa Davoli, Yumei Leng, Mamie Z Li, Qikai Xu, Stephen J Elledge
A large number of cancer drivers have been identified through tumor sequencing efforts, but how they interact and the degree to which they can substitute for each other have not been systematically explored. To comprehensively investigate how cancer drivers genetically interact, we searched for modifiers of epidermal growth factor receptor (EGFR) dependency by performing CRISPR, shRNA, and expression screens in a non-small cell lung cancer (NSCLC) model. We elucidated a broad spectrum of tumor suppressor genes (TSGs) and oncogenes (OGs) that can genetically modify proliferation and survival of cancer cells when EGFR signaling is altered...
January 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#3
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28137633/week-4-response-predicts-sustained-virologic-response-to-all-oral-direct-acting-antiviral-based-therapy-in-cirrhotic-patients-with-hepatitis-c-virus-genotype-3-infection
#4
Juan A Pineda, Luis E Morano-Amado, Rafael Granados, Juan Macías, Francisco Téllez, Miguel García-Deltoro, María J Ríos, Antonio Collado, Marcial Delgado-Fernández, Marta Suárez-Santamaría, Miriam Serrano, Celia Miralles-Álvarez, Karin Neukam
OBJECTIVE: The aim of this study was to determine the predictive capacity of response at treatment week (TW) 4 for the achievement of sustained virologic response 12 weeks after the scheduled end of therapy date (SVR12) to treatment against hepatitis C virus (HCV) genotype (GT) 3-infection with all-oral direct-acting antiviral (DAA)-based regimens. PATIENTS AND METHODS: From a prospective multicohort study, HCV GT3-infected patients who completed a course of currently recommended DAA-based therapy at 33 Spanish hospitals and who had reached SVR12 evaluation timepoint were selected...
January 27, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28126484/prevalence-of-hiv-infection-among-people-with-disabilities-a-population-based-observational-study-in-yaound%C3%A3-cameroon-handivih
#5
Pierre De Beaudrap, Gervais Beninguisse, Estelle Pasquier, Alice Tchoumkeu, Adonis Touko, Frida Essomba, Aude Brus, Toyin Janet Aderemi, Jill Hanass-Hancock, Arne Henning Eide, Muriel Mac-Seing, Daniel Mont
BACKGROUND: In resource-limited settings, people with disabilities have been left behind in the response to HIV. In the HandiVIH study, we estimate and compare HIV prevalence and associated risk factors between people with and without disabilities. METHODS: In this cross-sectional, population-based, observational study, we used two-phase random sampling to recruit adults with disabilities and a control group matched for age, sex, and residential location from households of the general population...
January 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28093222/swainsonine-induced-lysosomal-storage-disease-in-goats-caused-by-the-ingestion-of-sida-rodrigoi-monteiro-in-north-western-argentina
#6
Juan Francisco Micheloud, Raúl Marin, Luis Adrián Colque-Caro, Olga Gladys Martínez, Dale Gardner, Eduardo Juan Gimeno
There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins...
January 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28067836/alkaloids-and-phenolic-compounds-from-sida-rhombifolia-l-malvaceae-and-vasorelaxant-activity-of-two-indoquinoline-alkaloids
#7
Otemberg Souza Chaves, Yanna Carolina Ferreira Teles, Matheus Morais de Oliveira Monteiro, Leônidas das Graças Mendes Junior, Maria de Fátima Agra, Valdir de Andrade Braga, Tânia Maria Sarmento Silva, Maria de Fátima Vanderlei de Souza
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9)...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28063815/effect-of-immediate-initiation-of-antiretroviral-therapy-on-risk-of-severe-bacterial-infections-in-hiv-positive-people-with-cd4-cell-counts-of-more-than-500-cells-per-%C3%AE-l-secondary-outcome-results-from-a-randomised-controlled-trial
#8
Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Beatriz Grinsztejn, Gustavo Lopardo, Satyajit Das, Robin Wood, Aimee Wilkin, Hartwig Klinker, Pacharee Kantipong, Karin L Klingman, David Jilich, Elbushra Herieka, Eileen Denning, Ibrahim Abubakar, Fred Gordin, Jens D Lundgren
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial. METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells per μL...
January 4, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28058842/identification-and-quantitation-of-potent-odorants-in-spearmint-oils
#9
Lauren E Kelley, Keith R Cadwallader
Potent odorants in Native spearmint, Scotch spearmint, and Macho mint oils were determined by the combined use of gas chromatography-olfactometry (GCO), gas chromatography-mass spectrometry (GC-MS) and aroma extract dilution analysis (AEDA). Of the 85 odorants detected, (R)-(-)-carvone was the most potent odorant in all three spearmint oils. Additional predominant odorants in all spearmint oils included eugenol, ethyl (S)-(+)-2-methylbutanoate, (E)-β-damascenone, and (3E,5Z)-1,3,5-undecatriene. Forty-six compounds were quantitated using various methods, including 19 by gas chromatography with flame ionization detection (GC-FID), 20 by stable isotope dilution analysis (SIDA), and 14 by GCO dilution analysis...
January 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28049462/new-herbal-composition-oa-f2-protects-cartilage-degeneration-in-a-rat-model-of-collagenase-induced-osteoarthritis
#10
Pallavi S Nirmal, Suresh D Jagtap, Aarti N Narkhede, Bhagyashri E Nagarkar, Abhay M Harsulkar
BACKGROUND: Prevalence of osteoarthritis (OA) is on rise on the global scale. At present there are no satisfactory pharmacological agents for treating OA. Our previous study showed that Sida cordifolia L. and Zingiber officinale Rosc. had protective effect on cartilage. Here, we describe the effect of OA-F2, a herbal formulation prepared using combination of these two plants in alleviating OA associated symptoms in a rat model of collagenase-induced OA. METHODS: OA was induced by intra-articular injection of collagenase type II in wistar rats...
January 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28012586/isotopic-separation-of-acetaldehyde-and-methanol-from-their-deuterated-isotopologues-on-a-porous-layer-open-tubular-column-allows-quantification-by-stable-isotope-dilution-without-mass-spectrometric-detection
#11
Hans-Georg Schmarr, Michael Wacker, Maximilian Mathes
An isotopic separation of acetaldehyde and acetaldehyde-2,2,2-d3 was achieved in a temperature programmed run on a porous layer open tubular (PLOT) capillary column coated with particles of divinylbenzene ethylene glycol/dimethylacrylate (Rt(®)-U-BOND). This is the prerequisite for the development of quantitative analytical methods based on a stable isotope dilution assay (SIDA) without a mass spectrometric detection (non-MS SIDA). For routine analysis a flame ionization detector (FID) can thus be applied as a robust and low-cost alternative...
January 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012011/molecular-characterization-of-a-distinct-monopartite-begomovirus-associated-with-betasatellites-and-alphasatellites-infecting-pisum-sativum-in-nepal
#12
M S Shahid, B J Pudashini, G B Khatri-Chhetri, R W Briddon, K T Natsuaki
Pea (Pisum sativum) plants exhibiting leaf distortion, yellowing, stunted growth and reduction in leaf size from Rampur, Nepal were shown to be infected by a begomovirus in association with betasatellites and alphasatellites. The begomovirus associated with the disease showed only low levels of nucleotide sequence identity (<91%) to previously characterized begomoviruses. This finding indicates that the pea samples were infected with an as yet undescribed begomovirus for which the name Pea leaf distortion virus (PLDV) is proposed...
December 23, 2016: Virus Genes
https://www.readbyqxmd.com/read/27995509/the-evaluation-of-growth-and-phytoextraction-potential-of-miscanthus-x-giganteus-and-sida-hermaphrodita-on-soil-contaminated-simultaneously-with-cd-cu-ni-pb-and-zn
#13
Anna Kocoń, Beata Jurga
One of the cheapest, environmentally friendly methods for cleaning an environment polluted by heavy metals is phytoextraction. It builds on the uptake of pollutants from the soil by the plants, which are able to grow under conditions of high concentrations of toxic metals. The aim of this work was to assess the possibility of growing and phytoextraction potential of Miscanthus x giganteus and Sida hermaphrodita cultivated on two different soils contaminated with five heavy metals simultaneously: Cd, Cu, Ni, Pb, and Zn...
December 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27992218/characterization-of-the-key-aroma-compounds-in-heat-processed-licorice-succus-liquiritiae-by-means-of-molecular-sensory-science
#14
Juliane Wagner, Peter Schieberle, Michael Granvogl
Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylfuran-2(5H)-one, 4-hydroxy-3-methoxybenzaldehyde, 3-hydroxy-2-methyl-4H-pyran-4-one, and 2-methoxyphenol (all 1024)...
December 19, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27983809/a-collaborative-study-determination-of-mycotoxins-in-corn-peanut-butter-and-wheat-flour-using-stable-isotope-dilution-assay-sida-and-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#15
Kai Zhang, Matthew R Schaab, Gavin Southwood, Elizabeth R Tor, Linda S Aston, Wenlu Song, Brian Eitzer, Sanghamitra Majumdar, Theodore Lapainis, Huy Mai, Kevin Tran, Aref El-Demerdash, Victor Vega, Yanxuan Cai, Jon W Wong, Alexandra J Krynitsky, Timothy H Begley
A collaborative study was conducted to evaluate stable isotope dilution assay (SIDA) and LC-MS/MS for the simultaneous determination of aflatoxins B1, B2, G1, and G2; deoxynivalenol; fumonisins B1, B2, and B3; ochratoxin A; HT-2 toxin; T-2 toxin; and zearalenone in foods. Samples were fortified with 12 (13)C uniformly labeled mycotoxins ((13)C-IS) corresponding to the native mycotoxins and extracted with acetonitrile/water (50:50 v/v), followed by centrifugation, filtration, and LC-MS/MS analysis. In addition to certified reference materials, the six participating laboratories analyzed corn, peanut butter, and wheat flour fortified with the 12 mycotoxins at concentrations ranging from 1...
January 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27980831/crystal-and-mol-ecular-structures-of-two-silver-i-amidinates-including-an-unexpected-co-crystal-with-a-lithium-amidinate
#16
Sida Wang, Nicole Harmgarth, Phil Liebing, Frank T Edelmann
The silver(I) amidinates bis-[μ-N(1),N(2)-bis-(propan-2-yl)benzamidinato-κ(2)N(1):N(2)]disilver(I), [Ag2(C13H19N2)2] or [Ag{PhC(N (i) Pr)2}]2 (1), and bis-(μ-N(1),N(2)-di-cyclohexyl-3-cyclo-propyl-propynamidinato-κ(2)N(1):N(2))disilver(I), [Ag2(C18H27N2)2] or [Ag{cyclo-C3H5-C≡C-C(NCy)2}]2 (2a), exist as centrosymmetric dimers with a planar Ag2N4C2 ring and a common linear coordination of the metal atoms in the crystalline state. Moiety 2a forms a co-crystal with the related lithium amidinate, namely bis-(μ-N(1),N(2)-di-cyclo-hexyl-3-cyclo-propyl-propynamidinato-κ(2)N(1):N(2))disilver(I) bis-(μ-N(1),N(2)-di-cyclo-hexyl-3-cyclo-propyl-propynamidinato-κ(3)N(1),N(2):N(1))bis-(tetra-hydro-furan-κO)lithium(I) toluene monosolvate, [Ag2(C18H27N2)2][Li2(C18H27N2)2(C4H8O)2]·C7H8 or [Ag{cyclo-C3H5-C≡C-C(NCy)2}]2[Li{cyclo-C3H5-C≡C-C(NCy)2}(THF)]2·C7H8, composed as 2a × 2b × toluene...
December 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27979249/stable-isotope-dilution-assay-sida-and-hs-spme-gcms-quantification-of-key-aroma-volatiles-for-fruit-and-sap-of-australian-mango-cultivars
#17
Anh T San, Daryl C Joyce, Peter J Hofman, Andrew J Macnish, Richard I Webb, Nicolas J Matovic, Craig M Williams, James J De Voss, Siew H Wong, Heather E Smyth
Reported herein is a high throughput method to quantify in a single analysis the key volatiles that contribute to the aroma of commercially significant mango cultivars grown in Australia. The method constitutes stable isotope dilution analysis (SIDA) in conjunction with headspace (HS) solid-phase microextraction (SPME) coupled with gas-chromatography mass spectrometry (GCMS). Deuterium labelled analogues of the target analytes were either purchased commercially or synthesised for use as internal standards. Seven volatiles, hexanal, 3-carene, α-terpinene, p-cymene, limonene, α-terpinolene and ethyl octanoate, were targeted...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27975011/-well-digging-subcraniotomy-strategy-with-navigation-for-optic-nerve-decompression-in-frontoorbital-fibrous-dysplasia-preliminary-experience
#18
Yunhe Lu, Junyi Yang, Yingzhi Wu, Sida Pan, Jiawen Lu, Xiongzheng Mu
BACKGROUND: During the past decades, surgical intervention has been the primary treatment modality for frontoorbital fibrous dysplasia involving optic nerve. However, controversy has surrounded the role of optic nerve decompression in a number of ways. Herein, we describe 3 patients with frontoorbital fibrous dysplasia involving optic nerve, who underwent a "well digging" subcraniotomy strategy with navigation for intraorbital unit optic nerve decompression. METHODS: From 2013 to 2015, 3 patients with frontoorbital fibrous dysplasia were investigated in a retrospective manner...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27957687/evaluation-of-an-enzyme-immunoassay-for-the-detection-of-the-mycotoxin-tenuazonic-acid-in-sorghum-grains-and-sorghum-based-infant-food
#19
Madeleine Gross, Stefan Asam, Michael Rychlik
An enzyme-linked immunosorbent assay (ELISA) for the Alternaria mycotoxin tenuazonic acid (TeA) was evaluated by comparative analysis of naturally contaminated sorghum grains and sorghum-based infant food, using a stable isotope dilution LC-MS assay (SIDA; limit of detection (LOD) 1.0 μg/kg) as the reference method. LODs of the ELISA were 30 μg/kg in sorghum grains and 220 μg/kg in sorghum-based infant cereals. With SIDA, 100% of the samples (n = 28) had been positive for TeA in a concentration range of 6-584 μg/kg (mean 113 μg/kg)...
December 12, 2016: Mycotoxin Research
https://www.readbyqxmd.com/read/27920904/crystal-structures-of-two-ytterbium-iii-complexes-comprising-alkynylamidinate-ligands
#20
Sida Wang, Farid M Sroor, Phil Liebing, Volker Lorenz, Liane Hilfert, Frank T Edelmann
Two ytterbium(III) complexes comprising alkynylamidinate ligands, namely bis-(η(5)-cyclo-penta-dien-yl)(3-cyclo-propyl-N,N'-diiso-propyl-propynamidinato-κ(2)N,N')ytterbium(III), [Yb(C5H5)2(C12H19N2)] or Cp2Yb[( (i) Pr2N)2C-C≡C-c-C3H5] (1) and tris-(3-phenyl-N,N'-di-cyclo-hexyl-propynamidinato-κ(2)N,N')ytterbium(III), [Yb(C21H27N2)3] or Yb[(CyN)2C-C≡C-Ph]3 (Cy = cyclo-hex-yl) (2) have been synthesized and structurally characterized. Both complexes are monomers; for complex 2, the contribution to the scattering from highly disordered toluene solvent molecules in these voids was removed with the SQUEEZE routine [Spek (2015)...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
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