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https://www.readbyqxmd.com/read/28532150/synephrine-as-a-specific-marker-for-orange-consumption
#1
Matthias Bader, Tatjana Lang, Roman Lang, Thomas Hofmann
To validate the suitability of synephrine, known as a highly abundant alkaloid in oranges, as a dietary biomarker for orange consumption, a highly sensitive and robust stable isotope dilution analysis (SIDA) as well as an ECHO method, using the analyte itself as a pseudo-internal standard injected into the analysis run providing an "echo peak" of the analyte, was developed to quantitate synephrine by LC-MS/MS in citrus juices and human urine before and after ingestion of orange juice. A citrus juice screening revealed high synephrine concentrations of 150 to 420 nmol/mL in orange (n=11) and tangerine juices (n=2), while 20 to 100 times lower levels were found in juice from grapefruit (n=14), lemon (n=5) and lime (n=4), respectively...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28529969/antioxidant-and-synergistic-antidiabetic-activities-of-a-three-plant-preparation-used-in-cameroon-folk-medicine
#2
Bruno Moukette Moukette, Vicky Jocelyne Ama Moor, Cacral Prosper Biapa Nya, Pauline Nanfack, Francine Tankeu Nzufo, Marcel Azabji Kenfack, Jeanne Yonkeu Ngogang, Constant Anatole Pieme
Introduction. Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes. The aim of this study is to investigate the antidiabetic property of the aqueous mixture of three plant extracts (1 : 1 : 1) on streptozotocin induced diabetes rats. Methods. Diabetes was induced to rats by intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 50 mg/kg b.w...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28495593/enhanced-air-dispersion-modelling-at-a-typical-chinese-nuclear-power-plant-site-coupling-rimpuff-with-two-advanced-diagnostic-wind-models
#3
Yun Liu, Hong Li, Sida Sun, Sheng Fang
An enhanced air dispersion modelling scheme is proposed to cope with the building layout and complex terrain of a typical Chinese nuclear power plant (NPP) site. In this modelling, the California Meteorological Model (CALMET) and the Stationary Wind Fit and Turbulence (SWIFT) are coupled with the Risø Mesoscale PUFF model (RIMPUFF) for refined wind field calculation. The near-field diffusion coefficient correction scheme of the Atmospheric Relative Concentrations in the Building Wakes Computer Code (ARCON96) is adopted to characterize dispersion in building arrays...
May 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28472307/antiretroviral-treated-hiv-1-patients-can-harbour-resistant-viruses-in-csf-despite-an-undetectable-viral-load-in-plasma
#4
Cathia Soulie, Maxime Grudé, Diane Descamps, Corinne Amiel, Laurence Morand-Joubert, Stéphanie Raymond, Coralie Pallier, Pantxika Bellecave, Sandrine Reigadas, Mary-Anne Trabaud, Constance Delaugerre, Brigitte Montes, Francis Barin, Virginie Ferré, Hélène Jeulin, Chakib Alloui, Sabine Yerly, Anne Signori-Schmuck, Aurélie Guigon, Samira Fafi-Kremer, Stéphanie Haïm-Boukobza, Audrey Mirand, Anne Maillard, Sophie Vallet, Catherine Roussel, Lambert Assoumou, Vincent Calvez, Philippe Flandre, Anne-Geneviève Marcelin
Background: HIV therapy reduces the CSF HIV RNA viral load (VL) and prevents disorders related to HIV encephalitis. However, these brain disorders may persist in some cases. A large population of antiretroviral-treated patients who had a VL > 1.7 log 10 copies/mL in CSF with detectable or undetectable VL in plasma associated with cognitive impairment was studied, in order to characterize discriminatory factors of these two patient populations. Methods: Blood and CSF samples were collected at the time of neurological disorders for 227 patients in 22 centres in France and 1 centre in Switzerland...
May 2, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28459050/assessing-volumetric-absorptive-microsampling-coupled-with-stable-isotope-dilution-assay-and-liquid-chromatography-tandem-mass-spectrometry-as-potential-diagnostic-tool-for-whole-blood-5-methyltetrahydrofolic-acid
#5
Markus Kopp, Michael Rychlik
Volumetric absorptive microsamplers (VAMS) have been developed recently as a promising tool for clinical blood sampling. Compared to dried blood spot samples analyzed by accurate stable isotope dilution assays (SIDAs), the new technique could provide further substantial miniaturizing of folate assays by eliminating hematocrit effects and uneven analyte distribution within the sample. Herein, we present a miniaturized SIDA coupled with LC-MS/MS measurement of 5-methyltetrahydrofolic acid as main folate vitamer in whole blood (WB) using [(13)C5]-5-methyltetrahydrofolic acid as internal standard...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28457468/insights-into-cell-wall-structure-of-sida-hermaphrodita-and-its-influence-on-recalcitrance
#6
Tatjana Damm, Sivakumar Pattathil, Markus Günl, Nicolai David Jablonowski, Malcolm O'Neill, Katharina Susanne Grün, Philipp Michael Grande, Walter Leitner, Ulrich Schurr, Björn Usadel, Holger Klose
The perennial plant Sida hermaphrodita (Sida) is attracting attention as potential energy crop. Here, the first detailed view on non-cellulosic Sida cell wall polysaccharide composition, structure and architecture is given. Cell walls were prepared from Sida stems and sequentially extracted with aqueous buffers and alkali. The structures of the quantitatively predominant polysaccharides present in each fraction were determined by biochemical characterization, glycome profiling and mass spectrometry. The amounts of glucose released by Accellerase-1500(®) treatment of the cell wall and the cell wall residue remaining after each extraction were used to assess the roles of pectin and hemicellulose in the recalcitrance of Sida biomass...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28424024/molecular-profiling-and-bioactive-potential-of-an-endophytic-fungus-aspergillus-sulphureus-isolated-from-sida-acuta-a-medicinal-plant
#7
M Murali, C Mahendra, P Hema, N Rajashekar, A Nataraju, M S Sudarshana, K N Amruthesh
CONTEXT: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. OBJECTIVE: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. MATERIALS AND METHODS: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28404133/effect-on-hbs-antigen-clearance-of-addition-of-pegylated-interferon-alfa-2a-to-nucleos-t-ide-analogue-therapy-versus-nucleos-t-ide-analogue-therapy-alone-in-patients-with-hbe-antigen-negative-chronic-hepatitis-b-and-sustained-undetectable-plasma-hepatitis-b
#8
Marc Bourlière, Pascaline Rabiega, Nathalie Ganne-Carrie, Lawrence Serfaty, Patrick Marcellin, Yoann Barthe, Dominique Thabut, Dominique Guyader, Christophe Hezode, Magali Picon, Xavier Causse, Vincent Leroy, Jean Pierre Bronowicki, Patrizia Carrieri, Ghassan Riachi, Isabelle Rosa, Pierre Attali, Jean Michel Molina, Yannick Bacq, Albert Tran, Jean Didier Grangé, Fabien Zoulim, Hélène Fontaine, Laurent Alric, Inga Bertucci, Magali Bouvier-Alias, Fabrice Carrat
BACKGROUND: Findings from uncontrolled studies suggest that addition of pegylated interferon in patients with HBe antigen (HBeAg)-negative chronic hepatitis B receiving nucleos(t)ide analogues with undetectable plasma hepatitis B virus (HBV) DNA might increase HBs antigen (HBsAg) clearance. We aimed to assess this strategy. METHODS: In this randomised, controlled, open-label trial, we enrolled patients aged 18-75 years with HBeAg-negative chronic hepatitis B and documented negative HBV DNA while on stable nucleos(t)ide analogue regimens for at least 1 year from 30 hepatology tertiary care wards in France...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28377750/measurements-of-intra-and-extra-cellular-5-methyltetrahydrofolate-indicate-that-bifidobacterium-adolescentis-dsm-20083-t-and-bifidobacterium-pseudocatenulatum-dsm-20438-t-do-not-actively-excrete-5-methyltetrahydrofolate-in-vitro
#9
Markus Kopp, Kerstin Dürr, Matthias Steigleder, Thomas Clavel, Michael Rychlik
Certain intestinal bifidobacteria have the ability to synthesize folates. In vitro experiments revealed a high production, cellular accumulation, and release of reduced folate vitamers like 5-methyltetrahydrofolate and tetrahydrofolate in folate-free medium (FFM). However, it is still unclear to which extent synthesized folates are polyglutamylated and probably not available for transport, and if they are actively released by excretion. To address these questions, we characterized intra- and extra-cellular pteroylmonoglutamates and polyglutamylated 5-methyltetrahydrofolate (5-CH3-H4PteGlu2-4) in Bifidobacterium adolescentis DSM 20083(T) and Bifidobacterium pseudocatenulatum DSM 20438(T)in vitro...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28371162/protein-crosslinking-by-genetically-encoded-noncanonical-amino-acids-with-reactive-aryl-carbamate-side-chains
#10
Weimin Xuan, Sida Shao, Peter G Schultz
The use of genetically encoded noncanonical amino acids (ncAAs) to construct crosslinks within or between proteins has emerged as a useful method to enhance protein stability, investigate protein-protein interactions, and improve the pharmacological properties of proteins. We report ncAAs with aryl carbamate side chains (PheK and FPheK) that can react with proximal nucleophilic residues to form intra- or intermolecular protein crosslinks. We evolved a pyrrolysyl-tRNA synthetase that incorporates site-specifically PheK and FPheK into proteins in both E...
April 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28317203/attracting-enantiomers-chiral-analytes-that-are-simultaneously-shift-reagents-allow-rapid-screening-of-enantiomeric-ratios-by-nmr-spectroscopy
#11
Golo Storch, Maren Haas, Oliver Trapp
The rapid and direct determination of enantiomeric ratios is of increasing interest due to the significantly reduced effort compared to chromatographic methods and the large number of analytes, for instance in enantioselective catalysis. Current strategies include colorimetric assays, (a)chiral solvating reagents for NMR spectroscopy and metal complexes for CD sensing. We report the determination of enantiomeric ratios based on the self-induced diastereomeric anisochronism (SIDA) effect. Alanine derivatives that represent chiral products of enantioselective catalysis, such as the well-established hydrogenation of dehydroamino acids, were investigated...
April 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28306318/magnetic-trapping-of-cold-methyl-radicals
#12
Yang Liu, Manish Vashishta, Pavle Djuricanin, Sida Zhou, Wei Zhong, Tony Mittertreiner, David Carty, Takamasa Momose
We have demonstrated that a supersonic beam of methyl radicals (CH_{3}) in the ground rotational state of both para and ortho species has been slowed down to standstill with a magnetic molecular decelerator, and successfully captured spatially in an anti-Helmholtz magnetic trap for >1  s. The trapped CH_{3} radicals have a mean translational temperature of about 200 mK with an estimated density of >5.0×10^{7}  cm^{-3}. The methyl radical is an ideal system for the study of cold molecules not only because of its high reactivities at low temperatures, but also because further cooling below 1 mK is plausible via sympathetic cooling with ultracold atoms...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28289910/acid-base-disturbances-in-nephrotic-syndrome-analysis-using-the-co2-hco3-method-traditional-boston-model-and-the-physicochemical-method-stewart-model
#13
Tomomichi Kasagi, Hirokazu Imai, Naoto Miura, Keisuke Suzuki, Masabumi Yoshino, Hironobu Nobata, Takuhito Nagai, Shogo Banno
BACKGROUND: The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS: Twenty-nine patients with nephrotic syndrome and six patients without urinary protein or acid-base disturbances provided blood and urine samples for analysis that included routine biochemical and arterial blood gas tests, plasma renin activity, and aldosterone...
March 13, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28288839/the-role-of-high-dose-interleukin-2-in-the-era-of-targeted-therapy
#14
Jessie Gills, William P Parker, Scott Pate, Sida Niu, Peter Van Veldhuizen, Moben Mirza, Jeffery M Holzbeierlein, Eugene K Lee
OBJECTIVE: To assess survival outcomes following high dose IL-2 (HDIL-2) in a contemporary cohort of patients during the era of targeted agents. METHODS: Retrospective review of metastatic RCC patients treated with HDIL-2 between July 2007 and September 2014. Clinicopathologic data were abstracted and patient response to therapy was based on RECIST v1.1 criteria. The Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS) for the entire cohort, response to HDIL-2 in regards to previous targeted agent therapy, and response to targeted agent in relationship to response to HDIL-2...
March 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28282412/bead-mediated-separation-of-microparticles-in-droplets
#15
Sida Wang, Ki-Joo Sung, Xiaoxia Nina Lin, Mark A Burns
Exchange of components such as particles and cells in droplets is important and highly desired in droplet microfluidic assays, and many current technologies use electrical or magnetic fields to accomplish this process. Bead-based microfluidic techniques offer an alternative approach that uses the bead's solid surface to immobilize targets like particles or biological material. In this paper, we demonstrate a bead-based technique for exchanging droplet content by separating fluorescent microparticles in a microfluidic device...
2017: PloS One
https://www.readbyqxmd.com/read/28272436/cnt-enabled-co-braided-smart-fabrics-a-new-route-for-non-invasive-highly-sensitive-large-area-monitoring-of-composites
#16
Sida Luo, Yong Wang, Guantao Wang, Kan Wang, Zhibin Wang, Chuck Zhang, Ben Wang, Yun Luo, Liuhe Li, Tao Liu
The next-generation of hierarchical composites needs to have built-in functionality to continually monitor and diagnose their own health states. This paper includes a novel strategy for in-situ monitoring the processing stages of composites by co-braiding CNT-enabled fiber sensors into the reinforcing fiber fabrics. This would present a tremendous improvement over the present methods that excessively focus on detecting mechanical deformations and cracks. The CNT enabled smart fabrics, fabricated by a cost-effective and scalable method, are highly sensitive to monitor and quantify various events of composite processing including resin infusion, onset of crosslinking, gel time, degree and rate of curing...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262842/downregulation-of-mmp1-in-mds-derived-mesenchymal-stromal-cells-reduces-the-capacity-to-restrict-mds-cell-proliferation
#17
Sida Zhao, Youshan Zhao, Juan Guo, Chengming Fei, Qingqing Zheng, Xiao Li, Chunkang Chang
The role of mesenchymal stromal cells (MSCs) in the pathogenesis of myelodysplastic syndromes (MDS) has been increasingly addressed, but has yet to be clearly elucidated. In this investigation, we found that MDS cells proliferated to a greater extent on MDS-derived MSCs compared to normal MSCs. Matrix metalloproteinase 1(MMP1), which was downregulated in MDS-MSCs, was identified as an inhibitory factor of MDS cell proliferation, given that treatment with an MMP1 inhibitor or knock-down of MMP1 in normal MSCs resulted in increased MDS cell proliferation...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261625/isolation-and-identification-of-legionella-spp-from-different-aquatic-sources-in-south-west-of-iran-by-molecular-culture-methods
#18
Mohammad Tabatabaei, Zahra Hemati, Maryam-O-Sadat Moezzi, Negar Azimzadeh
Legionella pneumophila, the causative agent of Legionnaires' diseases (LD) is usually transmitted to humans via inhalation of aerosols from contaminated natural and manmade water sources. These organisms may become fatal especially in immunocompromised patients and LD is the one of the important disease from a public health perspective. This survey investigated the frequency of Legionella spp. including L. pneumophila, in some cold and warm water systems in South-West of Iran by culture and PCR methods. Thirty four water samples were collected from diverse water supply systems...
December 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28167974/preventive-effects-of-a-chinese-herbal-formula-shengjiang-xiexin-decoction-on-irinotecan-induced-delayed-onset-diarrhea-in-rats
#19
Chao Deng, Bo Deng, Liqun Jia, Huangying Tan, Pan Zhang, Sida Liu, Yanan Zhang, Aiping Song, Lin Pan
Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28167502/a-genetic-interaction-analysis-identifies-cancer-drivers-that-modify-egfr-dependency
#20
Sida Liao, Teresa Davoli, Yumei Leng, Mamie Z Li, Qikai Xu, Stephen J Elledge
A large number of cancer drivers have been identified through tumor sequencing efforts, but how they interact and the degree to which they can substitute for each other have not been systematically explored. To comprehensively investigate how cancer drivers genetically interact, we searched for modifiers of epidermal growth factor receptor (EGFR) dependency by performing CRISPR, shRNA, and expression screens in a non-small cell lung cancer (NSCLC) model. We elucidated a broad spectrum of tumor suppressor genes (TSGs) and oncogenes (OGs) that can genetically modify proliferation and survival of cancer cells when EGFR signaling is altered...
January 15, 2017: Genes & Development
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