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https://www.readbyqxmd.com/read/28807189/effect-of-non-monetary-incentives-on-uptake-of-couples-counselling-and-testing-among-clients-attending-mobile-hiv-services-in-rural-zimbabwe-a-cluster-randomised-trial
#1
Euphemia L Sibanda, Mary Tumushime, Juliet Mufuka, Sue Napierala Mavedzenge, Stephano Gudukeya, Sergio Bautista-Arredondo, Karin Hatzold, Harsha Thirumurthy, Sandra I McCoy, Nancy Padian, Andrew Copas, Frances M Cowan
BACKGROUND: Couples' HIV testing and counselling (CHTC) is associated with greater engagement with HIV prevention and care than individual testing and is cost-effective, but uptake remains suboptimal. Initiating discussion of CHTC might result in distrust between partners. Offering incentives for CHTC could change the focus of the pre-test discussion. We aimed to determine the impact of incentives for CHTC on uptake of couples testing and HIV case diagnosis in rural Zimbabwe. METHODS: In this cluster-randomised trial, 68 rural communities (the clusters) in four districts receiving mobile HIV testing services were randomly assigned (1:1) to incentives for CHTC or not...
September 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28805559/effect-of-stress-on-the-expression-of-galanin-receptors-in-rat-heart
#2
J Šípková, P Šída, N Kaspříková, I Kramáriková, S Hynie, V Klenerová
Neuropeptide galanin, galanin-like peptide and galanin receptors 1, 2 and 3 are a crucial part of the so-called galaninergic system. Our previous studies have shown the possible role of this system in mood modulation, especially regarding stress. So far, the galanin receptors have been found in different tissues including brain and heart. Our study deals with changes in expression of galanin receptor subtypes in the heart of Wistar rats exposed to three different types of stress. Galanin receptor subtypes were determined in fluorescently labelled samples using specific primary antibodies, and all sections were analysed in an immunofluorescent microscope and microphotographs...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#3
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
July 21, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28732358/lenalidomide-restores-the-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-from-multiple-myeloma-patients-via-deactivating-notch-signaling-pathway
#4
Juan Guo, Chengming Fei, Youshan Zhao, Sida Zhao, Qingqing Zheng, Jiying Su, Dong Wu, Xiao Li, Chunkang Chang
Multiple myeloma (MM) always presents osteolytic bone lesions, resulting from the abnormal osteoblastic and osteoclastic function in patients. MM patients exhibit the impairment of osteogenic differentiation of BMMSCs (bone marrow mesenchymal stem cells) and osteoblast deficiency. Effects of the drug, lenalidomide on the osteoblastic functions and the involved mechanisms remain unexplored. In the present study, it is observed that the osteogenic differentiation of BMMSCs from MM patients (MM-MSCs) is impaired and activation of Notch signaling pathway in MM-MSCs is abnormal...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28656290/mir-367-promotes-tumor-growth-by-inhibiting-fbxw7-in-nsclc
#5
Guodong Xiao, Xiao Gao, Xin Sun, Chengcheng Yang, Boxiang Zhang, Ruiying Sun, Guanghong Huang, Xiang Li, Jian Liu, Ning Du, Dapeng Liu, Rui Liang, Hong Ren, Sida Qin
miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small cell lung cancer (NSCLC). In the present study, we demonstrated that the level of miR-367 in NSCLC was significantly higher than that in adjacent normal tissues, and its upregulation was positively correlated with tumor size, tumor differentiation and tumor-node-metastasis (TNM) stage...
June 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28628326/improved-sodium-ion-storage-performance-of-ultrasmall-iron-selenide-nanoparticles
#6
Feipeng Zhao, Sida Shen, Liang Cheng, Lu Ma, Junhua Zhou, Hualin Ye, Na Han, Tianpin Wu, Yanguang Li, Jun Lu
Sodium-ion batteries are potential low-cost alternatives to current lithium-ion technology, yet their performances still fall short of expectation due to the lack of suitable electrode materials with large capacity, long-term cycling stability, and high-rate performance. In this work, we demonstrated that ultrasmall (∼5 nm) iron selenide (FeSe2) nanoparticles exhibited a remarkable activity for sodium-ion storage. They were prepared from a high-temperature solution method with a narrow size distribution and high yield and could be readily redispersed in nonpolar organic solvents...
June 28, 2017: Nano Letters
https://www.readbyqxmd.com/read/28609938/illustrated-review-of-the-leaf-mining-nepticulidae-of-the-central-andes%C3%A2-peru-and-bolivia
#7
Jonas R Stonis, Arūnas Diškus, Andrius Remeikis, Ole Karsholt, Nixon Cumbicus Torres
We review forty-five species of Nepticulidae (Lepidoptera) based on an analysis of samples collected in the central Andean region of Peru and Bolivia. Thirteen of these species are new to science, and are named and described here: Stigmella paracosma Remeikis & Stonis, sp. nov., S. expressa Remeikis & Stonis, sp. nov., S. acalyphae Diškus & Stonis, sp. nov., S. lepida Diškus & Stonis, sp. nov., S. misera Diškus & Stonis, sp. nov., S. inca Diškus & Stonis, sp. nov., S. eiffeli Diškus & Stonis, sp. nov., S...
April 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/28595126/effect-of-chelating-agents-on-reactive-green-19-decolorization-through-fe-0-activated-persulfate-oxidation-process
#8
Feng Ding, Hong Chen, Sida Zhang, Tongjun Zhao, Na Liu
The effect of chelating agents on the decolorization of Reactive Green 19 (RG19) through Fe(0) activated persulfate (PS/Fe(0)) process was investigated. Though other previous studies reported that chelating agent can enhance the degradation of organic contaminant in Fenton-like system, our finding showed that the presence of chelating agents would chelate free Fe(2+) and minimize free Fe(2+) concentration, which resulted in the retardation of RG19 decolorization. RG19 decolorization decreased to 7%, 21%, and 15% in the presence of sodium citrate, sodium EDTA, and sodium oxalate, compared with control test (without chelating agent, 99%) within 10 min...
June 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28577034/antero-lateral-minimally-invasive-plate-osteosynthesis-mipo-with-the-radial-nerve-exploration-for-extra-articular-distal-third-diaphyseal-fractures-of-the-humerus
#9
Wei Zhao, Wei Qu, Chongyang Fu, Huajun Jiang, Sida Liu, Chao Cheng
INTRODUCTION: Traditional open reduction and internal fixation (ORIF) of extra-articular distal humerus fractures has a risk of iatrogenic radial nerve injury, extensive soft tissue stripping, and long incision scar. We performed an antero-lateral minimally invasive plate osteosynthesis (MIPO) technique with the radial nerve exploration for distal-third diaphyseal fractures of the humerus and evaluated clinical and radiographic outcomes through this respective study. METHODS: From April 2010 to June 2016, 28 cases of extra-articular distal-third diaphyseal fractures were treated with an antero-lateral MIPO procedure...
June 2, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28566227/boosted-protease-inhibitor-monotherapy-versus-boosted-protease-inhibitor-plus-lamivudine-dual-therapy-as-second-line-maintenance-treatment-for-hiv-1-infected-patients-in-sub-saharan-africa-anrs12-286-mobidip-a-multicentre-randomised-parallel-open-label-superiority
#10
Laura Ciaffi, Sinata Koulla-Shiro, Adrien Bruno Sawadogo, Cheik Tidiane Ndour, Sabrina Eymard-Duvernay, Pretty Rosereine Mbouyap, Liliane Ayangma, Jacques Zoungrana, Ndeye Fatou Ngom Gueye, Mohamadou Diallo, Suzanne Izard, Guillaume Bado, Coumba Toure Kane, Avelin Fobang Aghokeng, Martine Peeters, Pierre Marie Girard, Vincent Le Moing, Jacques Reynes, Eric Delaporte
BACKGROUND: Despite satisfactory efficacy of WHO-recommended second-line antiretroviral treatment for patients with HIV in low-income countries, the need for simplified, low-cost, and less-toxic maintenance strategies remains high. We compared boosted protease inhibitor monotherapy with dual therapy with boosted protease inhibitor plus lamivudine in patients on second-line antiretrovial therapy (ART). METHODS: We did a multicentre, randomised, parallel, open-label, superiority, trial in the HIV services of five hospitals in sub-Saharan Africa (Yaoundé, Cameroon; Dakar, Senegal; and Bobo Dioulasso, Burkina Faso)...
May 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28562743/reproductive-aspects-and-knowledge-of-family-planning-among-women-with-acquired-immunodeficiency-syndrome
#11
Ivana Cristina Vieira de Lima, Maria da Conceição Dos Santos Oliveira Cunha, Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão
OBJECTIVE: To analyze the reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome (AIDS). METHOD: Cross-sectional and descriptive study carried out from January to December, 2015, in the outpatient care of infectious disease unit in a hospital located in Fortaleza, Ceará. Data were collected through a form applied by interview in a private setting. RESULTS: 102 women participated in the study...
May 25, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28532150/synephrine-as-a-specific-marker-for-orange-consumption
#12
Matthias Bader, Tatjana Lang, Roman Lang, Thomas Hofmann
To validate the suitability of synephrine, known to be a highly abundant alkaloid in oranges, as a dietary biomarker for orange consumption, a highly sensitive and robust stable isotope dilution analysis (SIDA) as well as an ECHO method, using the analyte itself as a pseudointernal standard injected into the analysis run to provide an "echo peak" of the analyte, was developed to quantitate synephrine by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in citrus juices and human urine before and after the ingestion of orange juice...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28529969/antioxidant-and-synergistic-antidiabetic-activities-of-a-three-plant-preparation-used-in-cameroon-folk-medicine
#13
Bruno Moukette Moukette, Vicky Jocelyne Ama Moor, Cacral Prosper Biapa Nya, Pauline Nanfack, Francine Tankeu Nzufo, Marcel Azabji Kenfack, Jeanne Yonkeu Ngogang, Constant Anatole Pieme
Introduction. Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes. The aim of this study is to investigate the antidiabetic property of the aqueous mixture of three plant extracts (1 : 1 : 1) on streptozotocin induced diabetes rats. Methods. Diabetes was induced to rats by intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 50 mg/kg b.w...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28495593/enhanced-air-dispersion-modelling-at-a-typical-chinese-nuclear-power-plant-site-coupling-rimpuff-with-two-advanced-diagnostic-wind-models
#14
Yun Liu, Hong Li, Sida Sun, Sheng Fang
An enhanced air dispersion modelling scheme is proposed to cope with the building layout and complex terrain of a typical Chinese nuclear power plant (NPP) site. In this modelling, the California Meteorological Model (CALMET) and the Stationary Wind Fit and Turbulence (SWIFT) are coupled with the Risø Mesoscale PUFF model (RIMPUFF) for refined wind field calculation. The near-field diffusion coefficient correction scheme of the Atmospheric Relative Concentrations in the Building Wakes Computer Code (ARCON96) is adopted to characterize dispersion in building arrays...
September 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28472307/antiretroviral-treated-hiv-1-patients-can-harbour-resistant-viruses-in-csf-despite-an-undetectable-viral-load-in-plasma
#15
Cathia Soulie, Maxime Grudé, Diane Descamps, Corinne Amiel, Laurence Morand-Joubert, Stéphanie Raymond, Coralie Pallier, Pantxika Bellecave, Sandrine Reigadas, Mary-Anne Trabaud, Constance Delaugerre, Brigitte Montes, Francis Barin, Virginie Ferré, Hélène Jeulin, Chakib Alloui, Sabine Yerly, Anne Signori-Schmuck, Aurélie Guigon, Samira Fafi-Kremer, Stéphanie Haïm-Boukobza, Audrey Mirand, Anne Maillard, Sophie Vallet, Catherine Roussel, Lambert Assoumou, Vincent Calvez, Philippe Flandre, Anne-Geneviève Marcelin
Background: HIV therapy reduces the CSF HIV RNA viral load (VL) and prevents disorders related to HIV encephalitis. However, these brain disorders may persist in some cases. A large population of antiretroviral-treated patients who had a VL > 1.7 log 10 copies/mL in CSF with detectable or undetectable VL in plasma associated with cognitive impairment was studied, in order to characterize discriminatory factors of these two patient populations. Methods: Blood and CSF samples were collected at the time of neurological disorders for 227 patients in 22 centres in France and 1 centre in Switzerland...
May 2, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28459050/assessing-volumetric-absorptive-microsampling-coupled-with-stable-isotope-dilution-assay-and-liquid-chromatography-tandem-mass-spectrometry-as-potential-diagnostic-tool-for-whole-blood-5-methyltetrahydrofolic-acid
#16
Markus Kopp, Michael Rychlik
Volumetric absorptive microsamplers (VAMS) have been developed recently as a promising tool for clinical blood sampling. Compared to dried blood spot samples analyzed by accurate stable isotope dilution assays (SIDAs), the new technique could provide further substantial miniaturizing of folate assays by eliminating hematocrit effects and uneven analyte distribution within the sample. Herein, we present a miniaturized SIDA coupled with LC-MS/MS measurement of 5-methyltetrahydrofolic acid as main folate vitamer in whole blood (WB) using [(13)C5]-5-methyltetrahydrofolic acid as internal standard...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28457468/insights-into-cell-wall-structure-of-sida-hermaphrodita-and-its-influence-on-recalcitrance
#17
Tatjana Damm, Sivakumar Pattathil, Markus Günl, Nicolai David Jablonowski, Malcolm O'Neill, Katharina Susanne Grün, Philipp Michael Grande, Walter Leitner, Ulrich Schurr, Björn Usadel, Holger Klose
The perennial plant Sida hermaphrodita (Sida) is attracting attention as potential energy crop. Here, the first detailed view on non-cellulosic Sida cell wall polysaccharide composition, structure and architecture is given. Cell walls were prepared from Sida stems and sequentially extracted with aqueous buffers and alkali. The structures of the quantitatively predominant polysaccharides present in each fraction were determined by biochemical characterization, glycome profiling and mass spectrometry. The amounts of glucose released by Accellerase-1500(®) treatment of the cell wall and the cell wall residue remaining after each extraction were used to assess the roles of pectin and hemicellulose in the recalcitrance of Sida biomass...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28424024/molecular-profiling-and-bioactive-potential-of-an-endophytic-fungus-aspergillus-sulphureus-isolated-from-sida-acuta-a-medicinal-plant
#18
M Murali, C Mahendra, P Hema, N Rajashekar, A Nataraju, M S Sudarshana, K N Amruthesh
CONTEXT: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. OBJECTIVE: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. MATERIALS AND METHODS: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28404133/effect-on-hbs-antigen-clearance-of-addition-of-pegylated-interferon-alfa-2a-to-nucleos-t-ide-analogue-therapy-versus-nucleos-t-ide-analogue-therapy-alone-in-patients-with-hbe-antigen-negative-chronic-hepatitis-b-and-sustained-undetectable-plasma-hepatitis-b
#19
Marc Bourlière, Pascaline Rabiega, Nathalie Ganne-Carrie, Lawrence Serfaty, Patrick Marcellin, Yoann Barthe, Dominique Thabut, Dominique Guyader, Christophe Hezode, Magali Picon, Xavier Causse, Vincent Leroy, Jean Pierre Bronowicki, Patrizia Carrieri, Ghassan Riachi, Isabelle Rosa, Pierre Attali, Jean Michel Molina, Yannick Bacq, Albert Tran, Jean Didier Grangé, Fabien Zoulim, Hélène Fontaine, Laurent Alric, Inga Bertucci, Magali Bouvier-Alias, Fabrice Carrat
BACKGROUND: Findings from uncontrolled studies suggest that addition of pegylated interferon in patients with HBe antigen (HBeAg)-negative chronic hepatitis B receiving nucleos(t)ide analogues with undetectable plasma hepatitis B virus (HBV) DNA might increase HBs antigen (HBsAg) clearance. We aimed to assess this strategy. METHODS: In this randomised, controlled, open-label trial, we enrolled patients aged 18-75 years with HBeAg-negative chronic hepatitis B and documented negative HBV DNA while on stable nucleos(t)ide analogue regimens for at least 1 year from 30 hepatology tertiary care wards in France...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28377750/measurements-of-intra-and-extra-cellular-5-methyltetrahydrofolate-indicate-that-bifidobacterium-adolescentis-dsm-20083-t-and-bifidobacterium-pseudocatenulatum-dsm-20438-t-do-not-actively-excrete-5-methyltetrahydrofolate-in-vitro
#20
Markus Kopp, Kerstin Dürr, Matthias Steigleder, Thomas Clavel, Michael Rychlik
Certain intestinal bifidobacteria have the ability to synthesize folates. In vitro experiments revealed a high production, cellular accumulation, and release of reduced folate vitamers like 5-methyltetrahydrofolate and tetrahydrofolate in folate-free medium (FFM). However, it is still unclear to which extent synthesized folates are polyglutamylated and probably not available for transport, and if they are actively released by excretion. To address these questions, we characterized intra- and extra-cellular pteroylmonoglutamates and polyglutamylated 5-methyltetrahydrofolate (5-CH3-H4PteGlu2-4) in Bifidobacterium adolescentis DSM 20083(T) and Bifidobacterium pseudocatenulatum DSM 20438(T)in vitro...
2017: Frontiers in Microbiology
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