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https://www.readbyqxmd.com/read/28424024/molecular-profiling-and-bioactive-potential-of-an-endophytic-fungus-aspergillus-sulphureus-isolated-from-sida-acuta-a-medicinal-plant
#1
M Murali, C Mahendra, P Hema, N Rajashekar, A Nataraju, M S Sudarshana, K N Amruthesh
CONTEXT: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. OBJECTIVE: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. MATERIALS AND METHODS: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28404133/effect-on-hbs-antigen-clearance-of-addition-of-pegylated-interferon-alfa-2a-to-nucleos-t-ide-analogue-therapy-versus-nucleos-t-ide-analogue-therapy-alone-in-patients-with-hbe-antigen-negative-chronic-hepatitis-b-and-sustained-undetectable-plasma-hepatitis-b
#2
Marc Bourlière, Pascaline Rabiega, Nathalie Ganne-Carrie, Lawrence Serfaty, Patrick Marcellin, Yoann Barthe, Dominique Thabut, Dominique Guyader, Christophe Hezode, Magali Picon, Xavier Causse, Vincent Leroy, Jean Pierre Bronowicki, Patrizia Carrieri, Ghassan Riachi, Isabelle Rosa, Pierre Attali, Jean Michel Molina, Yannick Bacq, Albert Tran, Jean Didier Grangé, Fabien Zoulim, Hélène Fontaine, Laurent Alric, Inga Bertucci, Magali Bouvier-Alias, Fabrice Carrat
BACKGROUND: Findings from uncontrolled studies suggest that addition of pegylated interferon in patients with HBe antigen (HBeAg)-negative chronic hepatitis B receiving nucleos(t)ide analogues with undetectable plasma hepatitis B virus (HBV) DNA might increase HBs antigen (HBsAg) clearance. We aimed to assess this strategy. METHODS: In this randomised, controlled, open-label trial, we enrolled patients aged 18-75 years with HBeAg-negative chronic hepatitis B and documented negative HBV DNA while on stable nucleos(t)ide analogue regimens for at least 1 year from 30 hepatology tertiary care wards in France...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28377750/measurements-of-intra-and-extra-cellular-5-methyltetrahydrofolate-indicate-that-bifidobacterium-adolescentis-dsm-20083-t-and-bifidobacterium-pseudocatenulatum-dsm-20438-t-do-not-actively-excrete-5-methyltetrahydrofolate-in-vitro
#3
Markus Kopp, Kerstin Dürr, Matthias Steigleder, Thomas Clavel, Michael Rychlik
Certain intestinal bifidobacteria have the ability to synthesize folates. In vitro experiments revealed a high production, cellular accumulation, and release of reduced folate vitamers like 5-methyltetrahydrofolate and tetrahydrofolate in folate-free medium (FFM). However, it is still unclear to which extent synthesized folates are polyglutamylated and probably not available for transport, and if they are actively released by excretion. To address these questions, we characterized intra- and extra-cellular pteroylmonoglutamates and polyglutamylated 5-methyltetrahydrofolate (5-CH3-H4PteGlu2-4) in Bifidobacterium adolescentis DSM 20083(T) and Bifidobacterium pseudocatenulatum DSM 20438(T)in vitro...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28371162/protein-crosslinking-by-genetically-encoded-noncanonical-amino-acids-with-reactive-aryl-carbamate-side-chains
#4
Weimin Xuan, Sida Shao, Peter G Schultz
The use of genetically encoded noncanonical amino acids (ncAAs) to construct crosslinks within or between proteins has emerged as a useful method to enhance protein stability, investigate protein-protein interactions, and improve the pharmacological properties of proteins. We report ncAAs with aryl carbamate side chains (PheK and FPheK) that can react with proximal nucleophilic residues to form intra- or intermolecular protein crosslinks. We evolved a pyrrolysyl-tRNA synthetase that incorporates site-specifically PheK and FPheK into proteins in both E...
April 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28317203/attracting-enantiomers-chiral-analytes-that-are-simultaneously-shift-reagents-allow-rapid-screening-of-enantiomeric-ratios-by-nmr-spectroscopy
#5
Golo Storch, Maren Haas, Oliver Trapp
The rapid and direct determination of enantiomeric ratios is of increasing interest due to the significantly reduced effort compared to chromatographic methods and the large number of analytes, for instance in enantioselective catalysis. Current strategies include colorimetric assays, (a)chiral solvating reagents for NMR spectroscopy and metal complexes for CD sensing. We report the determination of enantiomeric ratios based on the self-induced diastereomeric anisochronism (SIDA) effect. Alanine derivatives that represent chiral products of enantioselective catalysis, such as the well-established hydrogenation of dehydroamino acids, were investigated...
March 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28306318/magnetic-trapping-of-cold-methyl-radicals
#6
Yang Liu, Manish Vashishta, Pavle Djuricanin, Sida Zhou, Wei Zhong, Tony Mittertreiner, David Carty, Takamasa Momose
We have demonstrated that a supersonic beam of methyl radicals (CH_{3}) in the ground rotational state of both para and ortho species has been slowed down to standstill with a magnetic molecular decelerator, and successfully captured spatially in an anti-Helmholtz magnetic trap for >1  s. The trapped CH_{3} radicals have a mean translational temperature of about 200 mK with an estimated density of >5.0×10^{7}  cm^{-3}. The methyl radical is an ideal system for the study of cold molecules not only because of its high reactivities at low temperatures, but also because further cooling below 1 mK is plausible via sympathetic cooling with ultracold atoms...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28289910/acid-base-disturbances-in-nephrotic-syndrome-analysis-using-the-co2-hco3-method-traditional-boston-model-and-the-physicochemical-method-stewart-model
#7
Tomomichi Kasagi, Hirokazu Imai, Naoto Miura, Keisuke Suzuki, Masabumi Yoshino, Hironobu Nobata, Takuhito Nagai, Shogo Banno
BACKGROUND: The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS: Twenty-nine patients with nephrotic syndrome and six patients without urinary protein or acid-base disturbances provided blood and urine samples for analysis that included routine biochemical and arterial blood gas tests, plasma renin activity, and aldosterone...
March 13, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28288839/the-role-of-high-dose-interleukin-2-in-the-era-of-targeted-therapy
#8
Jessie Gills, William P Parker, Scott Pate, Sida Niu, Peter Van Veldhuizen, Moben Mirza, Jeffery M Holzbeierlein, Eugene K Lee
OBJECTIVE: To assess survival outcomes following high dose IL-2 (HDIL-2) in a contemporary cohort of patients during the era of targeted agents. METHODS: Retrospective review of metastatic RCC patients treated with HDIL-2 between July 2007 and September 2014. Clinicopathologic data were abstracted and patient response to therapy was based on RECIST v1.1 criteria. The Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS) for the entire cohort, response to HDIL-2 in regards to previous targeted agent therapy, and response to targeted agent in relationship to response to HDIL-2...
March 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28282412/bead-mediated-separation-of-microparticles-in-droplets
#9
Sida Wang, Ki-Joo Sung, Xiaoxia Nina Lin, Mark A Burns
Exchange of components such as particles and cells in droplets is important and highly desired in droplet microfluidic assays, and many current technologies use electrical or magnetic fields to accomplish this process. Bead-based microfluidic techniques offer an alternative approach that uses the bead's solid surface to immobilize targets like particles or biological material. In this paper, we demonstrate a bead-based technique for exchanging droplet content by separating fluorescent microparticles in a microfluidic device...
2017: PloS One
https://www.readbyqxmd.com/read/28272436/cnt-enabled-co-braided-smart-fabrics-a-new-route-for-non-invasive-highly-sensitive-large-area-monitoring-of-composites
#10
Sida Luo, Yong Wang, Guantao Wang, Kan Wang, Zhibin Wang, Chuck Zhang, Ben Wang, Yun Luo, Liuhe Li, Tao Liu
The next-generation of hierarchical composites needs to have built-in functionality to continually monitor and diagnose their own health states. This paper includes a novel strategy for in-situ monitoring the processing stages of composites by co-braiding CNT-enabled fiber sensors into the reinforcing fiber fabrics. This would present a tremendous improvement over the present methods that excessively focus on detecting mechanical deformations and cracks. The CNT enabled smart fabrics, fabricated by a cost-effective and scalable method, are highly sensitive to monitor and quantify various events of composite processing including resin infusion, onset of crosslinking, gel time, degree and rate of curing...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262842/downregulation-of-mmp1-in-mds-derived-mesenchymal-stromal-cells-reduces-the-capacity-to-restrict-mds-cell-proliferation
#11
Sida Zhao, Youshan Zhao, Juan Guo, Chengming Fei, Qingqing Zheng, Xiao Li, Chunkang Chang
The role of mesenchymal stromal cells (MSCs) in the pathogenesis of myelodysplastic syndromes (MDS) has been increasingly addressed, but has yet to be clearly elucidated. In this investigation, we found that MDS cells proliferated to a greater extent on MDS-derived MSCs compared to normal MSCs. Matrix metalloproteinase 1(MMP1), which was downregulated in MDS-MSCs, was identified as an inhibitory factor of MDS cell proliferation, given that treatment with an MMP1 inhibitor or knock-down of MMP1 in normal MSCs resulted in increased MDS cell proliferation...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261625/isolation-and-identification-of-legionella-spp-from-different-aquatic-sources-in-south-west-of-iran-by-molecular-culture-methods
#12
Mohammad Tabatabaei, Zahra Hemati, Maryam-O-Sadat Moezzi, Negar Azimzadeh
Legionella pneumophila, the causative agent of Legionnaires' diseases (LD) is usually transmitted to humans via inhalation of aerosols from contaminated natural and manmade water sources. These organisms may become fatal especially in immunocompromised patients and LD is the one of the important disease from a public health perspective. This survey investigated the frequency of Legionella spp. including L. pneumophila, in some cold and warm water systems in South-West of Iran by culture and PCR methods. Thirty four water samples were collected from diverse water supply systems...
December 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28167974/preventive-effects-of-a-chinese-herbal-formula-shengjiang-xiexin-decoction-on-irinotecan-induced-delayed-onset-diarrhea-in-rats
#13
Chao Deng, Bo Deng, Liqun Jia, Huangying Tan, Pan Zhang, Sida Liu, Yanan Zhang, Aiping Song, Lin Pan
Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28167502/a-genetic-interaction-analysis-identifies-cancer-drivers-that-modify-egfr-dependency
#14
Sida Liao, Teresa Davoli, Yumei Leng, Mamie Z Li, Qikai Xu, Stephen J Elledge
A large number of cancer drivers have been identified through tumor sequencing efforts, but how they interact and the degree to which they can substitute for each other have not been systematically explored. To comprehensively investigate how cancer drivers genetically interact, we searched for modifiers of epidermal growth factor receptor (EGFR) dependency by performing CRISPR, shRNA, and expression screens in a non-small cell lung cancer (NSCLC) model. We elucidated a broad spectrum of tumor suppressor genes (TSGs) and oncogenes (OGs) that can genetically modify proliferation and survival of cancer cells when EGFR signaling is altered...
January 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#15
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28137633/week-4-response-predicts-sustained-virological-response-to-all-oral-direct-acting-antiviral-based-therapy-in-cirrhotic-patients-with-hepatitis-c-virus-genotype-3-infection
#16
J A Pineda, L E Morano-Amado, R Granados, J Macías, F Téllez, M García-Deltoro, M J Ríos, A Collado, M Delgado-Fernández, M Suárez-Santamaría, M Serrano, C Miralles-Álvarez, K Neukam
OBJECTIVE: The aim of this study was to determine the predictive capacity of response at treatment week (TW) 4 for the achievement of sustained virological response 12 weeks after the scheduled end of therapy date (SVR12) to treatment against hepatitis C virus (HCV) genotype 3 (GT3) infection with all-oral direct-acting antiviral (DAA) -based regimens. PATIENTS AND METHODS: From a prospective multicohort study, HCV GT3-infected patients who completed a course of currently recommended DAA-based therapy at 33 Spanish hospitals and who had reached the SVR12 evaluation time-point were selected...
January 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28126484/prevalence-of-hiv-infection-among-people-with-disabilities-a-population-based-observational-study-in-yaound%C3%A3-cameroon-handivih
#17
Pierre De Beaudrap, Gervais Beninguisse, Estelle Pasquier, Alice Tchoumkeu, Adonis Touko, Frida Essomba, Aude Brus, Toyin Janet Aderemi, Jill Hanass-Hancock, Arne Henning Eide, Muriel Mac-Seing, Daniel Mont
BACKGROUND: In resource-limited settings, people with disabilities have been left behind in the response to HIV. In the HandiVIH study, we estimate and compare HIV prevalence and associated risk factors between people with and without disabilities. METHODS: In this cross-sectional, population-based, observational study, we used two-phase random sampling to recruit adults with disabilities and a control group matched for age, sex, and residential location from households of the general population...
January 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28093222/swainsonine-induced-lysosomal-storage-disease-in-goats-caused-by-the-ingestion-of-sida-rodrigoi-monteiro-in-north-western-argentina
#18
Juan Francisco Micheloud, Raúl Marin, Luis Adrián Colque-Caro, Olga Gladys Martínez, Dale Gardner, Eduardo Juan Gimeno
There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins...
January 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28067836/alkaloids-and-phenolic-compounds-from-sida-rhombifolia-l-malvaceae-and-vasorelaxant-activity-of-two-indoquinoline-alkaloids
#19
Otemberg Souza Chaves, Yanna Carolina Ferreira Teles, Matheus Morais de Oliveira Monteiro, Leônidas das Graças Mendes Junior, Maria de Fátima Agra, Valdir de Andrade Braga, Tânia Maria Sarmento Silva, Maria de Fátima Vanderlei de Souza
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9)...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28063815/effect-of-immediate-initiation-of-antiretroviral-therapy-on-risk-of-severe-bacterial-infections-in-hiv-positive-people-with-cd4-cell-counts-of-more-than-500-cells-per-%C3%AE-l-secondary-outcome-results-from-a-randomised-controlled-trial
#20
Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Beatriz Grinsztejn, Gustavo Lopardo, Satyajit Das, Robin Wood, Aimee Wilkin, Hartwig Klinker, Pacharee Kantipong, Karin L Klingman, David Jilich, Elbushra Herieka, Eileen Denning, Ibrahim Abubakar, Fred Gordin, Jens D Lundgren
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial. METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells per μL...
March 2017: Lancet HIV
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