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https://www.readbyqxmd.com/read/29229440/post-exposure-prophylaxis-with-doxycycline-to-prevent-sexually-transmitted-infections-in-men-who-have-sex-with-men-an-open-label-randomised-substudy-of-the-anrs-ipergay-trial
#1
Jean-Michel Molina, Isabelle Charreau, Christian Chidiac, Gilles Pialoux, Eric Cua, Constance Delaugerre, Catherine Capitant, Daniela Rojas-Castro, Julien Fonsart, Béatrice Bercot, Cécile Bébéar, Laurent Cotte, Olivier Robineau, François Raffi, Pierre Charbonneau, Alexandre Aslan, Julie Chas, Laurence Niedbalski, Bruno Spire, Luis Sagaon-Teyssier, Diane Carette, Soizic Le Mestre, Veronique Doré, Laurence Meyer
BACKGROUND: Increased rates of sexually transmitted infections (STIs) have been reported among men who have sex with men. We aimed to assess whether post-exposure prophylaxis (PEP) with doxycycline could reduce the incidence of STIs. METHODS: All participants attending their scheduled visit in the open-label extension of the ANRS IPERGAY trial in France (men aged 18 years or older having condomless sex with men and using pre-exposure prophylaxis for HIV with tenofovir disoproxil fumarate plus emtricitabine) were eligible for inclusion in this open-label randomised study...
December 8, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29228631/identification-of-differentially-expressed-genes-lncrnas-and-mirnas-which-are-associated-with-tumor-malignant-phenotypes-in-hepatoblastoma-patients
#2
Sida Liu, Fujing Xie, Xiaohong Xiang, Sinan Liu, Shunbin Dong, Kai Qu, Ting Lin
Hepatoblastoma (HB) is one of the most common hepatic malignancies in the pediatric population. HB are composed of a variety of tumors, which derived from different origins and had varying clinical outcomes. However, the unclear underlying mechanisms of HB limited exploring novel biomarkers and effective therapeutic targets. We searched microarray datasets on Gene Expression Omnibus (GEO) database and selected GSE75271 and GSE75283 datasets for comprehensive analysis. Weighted gene correlation network analysis (WGCNA) was employed to identify genes which were associated with tumor malignant phenotypes, including HB subtypes, Cairo classification and tumor stage...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29181236/machine-learning-to-improve-the-effectiveness-of-anrs-in-predicting-hiv-drug-resistance
#3
Yashik Singh
Objectives: Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is one of the major burdens of disease in developing countries, and the standard-of-care treatment includes prescribing antiretroviral drugs. However, antiretroviral drug resistance is inevitable due to selective pressure associated with the high mutation rate of HIV. Determining antiretroviral resistance can be done by phenotypic laboratory tests or by computer-based interpretation algorithms...
October 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29178789/chelator-free-labeling-of-metal-oxide-nanostructures-with-zirconium-89-for-positron-emission-tomography-imaging
#4
Liang Cheng, Sida Shen, Dawei Jiang, Qiutong Jin, Paul A Ellison, Emily B Ehlerding, Shreya Goel, Guosheng Song, Peng Huang, Todd E Barnhart, Zhuang Liu, Weibo Cai
Radiolabeling of molecules or nanoparticles to form imaging probes is critical for positron emission tomography (PET) imaging, which, with high sensitivity and the ability for quantitative imaging, has been widely used in the clinic. While conventional radiolabeling often employs chelator molecules, a general method for chelator-free radiolabeling of a wide range of materials remains to be developed. Herein, we uncovered that ten different types of metal oxide (MxOy, M=Gd, Ti, Te, Eu, Ta, Er, Y, Yb, Ce, or Mo, x=1-2, y=2-5) nanomaterials with polyethylene glycol (PEG) modification could be labeled with 89Zr, a PET tracer, via a simple yet general chelator-free radiolabeling method upon simple mixing...
November 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29176879/socio-demographic-predictors-of-health-and-environmental-co-benefit-behaviours-for-climate-change-mitigation-in-urban-china
#5
Emily Ying Yang Chan, Susan Shuxin Wang, Janice Ying-En Ho, Zhe Huang, Sida Liu, Chunlan Guo
OBJECTIVE: This study aims to examine the patterns and socio-demographic predictors of health and environmental co-benefit behaviours that support climate change mitigation in a densely populated Asian metropolis-Hong Kong. METHODS: A population-based, stratified and cross-sectional random digit dialling telephone survey study was conducted between January and February 2016, among the Cantonese-speaking population aged 15 and above in Hong Kong. Socio-demographic data and the self-reported practice of 10 different co-benefit behaviours were solicited...
2017: PloS One
https://www.readbyqxmd.com/read/29167255/complete-genome-sequences-of-two-plant-associated-pseudomonas-putida-isolates-with-increased-heavy-metal-tolerance
#6
Joseph Nesme, Barbara Cania, Urška Zadel, Anne Schöler, Grażyna A Płaza, Michael Schloter
We report here the complete genome sequences of two Pseudomonas putida isolates recovered from surface-sterilized roots of Sida hermaphrodita The two isolates were characterized by an increased tolerance to zinc, cadmium, and lead. Furthermore, the strains showed typical plant growth-promoting properties, such as the production of indole acetic acid, cellulolytic enzymes, and siderophores.
November 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29165872/manganese-dioxide-coated-ws2-fe3-o4-ssio2-nanocomposites-for-ph-responsive-mr-imaging-and-oxygen-elevated-synergetic-therapy
#7
Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attached...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29155067/contrasting-roles-of-fungal-siderophores-in-maintaining-iron-homeostasis-in-epichlo%C3%A3-festucae
#8
Natasha T Forester, Geoffrey A Lane, Melle Steringa, Iain L Lamont, Linda J Johnson
The symbiosis between Epichloë festucae and its host perennial ryegrass (Lolium perenne) is a model system for mutualistic interactions in which the fungal endophyte grows between plant shoot cells and acquires host nutrients to survive. E. festucae synthesises the siderophore epichloënin A (EA) via SidN, a non-ribosomal peptide synthetase (NRPS). EA is involved in the acquisition of iron, an essential micronutrient, as part of the process of maintaining a stable symbiotic interaction. Here, we mutated a different NRPS gene sidC and showed that it is required for production of a second siderophore ferricrocin (FC)...
November 15, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29153090/chiral-analysis-of-3-sulfanylhexan-1-ol-and-3-sulfanylhexyl-acetate-in-wine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#9
Liang Chen, Dimitra L Capone, David W Jeffery
A number of polyfunctional thiols are well-recognised as some of the most potent aroma compounds in nature and have been identified in various foods, and beverages such as wine. These potent character impact compounds are present at nanogram-per-litre levels and are particularly challenging to measure. Where present, enantiomeric forms having different odour qualities further complicate the analysis. In this work, a chiral high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method using stable isotope dilution analysis (SIDA) has been developed and validated for the individual enantiomers of 3-sulfanylhexan-1-ol (3-SH, 1) and its O-acetate, 3-sulfanylhexyl acetate (3-SHA, 2), in wine after extraction as their 4-thiopyridine derivatives...
January 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29115149/low-baseline-awareness-of-gastric-cancer-risk-factors-amongst-at-risk-multiracial-ethnic-populations-in-new-york-city-results-of-a-targeted-culturally-sensitive-pilot-gastric-cancer-community-outreach-program
#10
Shailja C Shah, Helen Nunez, Sophia Chiu, Ariel Hazan, Sida Chen, Shutao Wang, Steven Itzkowitz, Lina Jandorf
BACKGROUND AND AIMS: There are limited efforts to address modifiable risk factors for gastric cancer (GC) among racial/ethnic groups at higher GC risk, which may reflect decreased public awareness of risk factors. Our primary aim was to assess baseline awareness of GC risk factors and attitudes/potential barriers for uptake of a GC screening program among high-risk individuals. METHODS: Participants attended a linguistically and culturally targeted GC educational program in East Harlem (EH)/Bronx and Chinatown communities in New York City...
November 8, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29099738/anti-inflammatory-effect-of-malva-sylvestris-sida-cordifolia-and-pelargonium-graveolens-is-related-to-inhibition-of-prostanoid-production
#11
Cleverson Antonio Ferreira Martins, Michel Leandro Campos, Ana Carolina Irioda, Dile Pontarolo Stremel, Angela Cristina Leal Badaró Trindade, Roberto Pontarolo
The ability of plant extracts and preparations to reduce inflammation has been proven by different means in experimental models. Since inflammation enhances the release of specific mediators, inhibition of their production can be used to investigate the anti-inflammatory effect of plants widely used in folk medicine for this purpose. The study was performed for leaves and flowers of Malva sylvestris, and leaves of Sida cordifolia and Pelargonium graveolens. These are three plant species known in Brazil as Malva...
November 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29099110/cognitive-impairment-among-older-adults-living-with-hiv-aids-and-frailty
#12
Alfonso Zamudio-Rodríguez, Sara Aguilar-Navarro, José Alberto Avila-Funes
In 2014, 17% of newly diagnosed HIV infection cases in the United States were made in people over 50 years of age; actually, it is expected that in the near future this population group will be the most affected. This epidemiological change can be explained by the increased incidence of HIV infection in people over 50 years, but also by its higher prevalence due to treatment advances. As HIV infection has become a chronic one, new challenges have emerged. For instance, early-onset "geriatric syndromes," such as frailty, have been recognized in these patients...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29077054/development-of-a-chimeric-antigen-receptor-targeting-c-type-lectin-like-molecule-1-for-human-acute-myeloid-leukemia
#13
Eduardo Laborda, Magdalena Mazagova, Sida Shao, Xinxin Wang, Herlinda Quirino, Ashley K Woods, Eric N Hampton, David T Rodgers, Chan Hyuk Kim, Peter G Schultz, Travis S Young
The treatment of patients with acute myeloid leukemia (AML) with targeted immunotherapy is challenged by the heterogeneity of the disease and a lack of tumor-exclusive antigens. Conventional immunotherapy targets for AML such as CD33 and CD123 have been proposed as targets for chimeric antigen receptor (CAR)-engineered T-cells (CAR-T-cells), a therapy that has been highly successful in the treatment of B-cell leukemia and lymphoma. However, CD33 and CD123 are present on hematopoietic stem cells, and targeting with CAR-T-cells has the potential to elicit long-term myelosuppression...
October 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29057840/ethnomedicinal-phytochemical-and-ethnopharmacological-aspects-of-four-medicinal-plants-of-malvaceae-used-in-indian-traditional-medicines-a-review
#14
REVIEW
Jasmeet Kaur Abat, Sanjay Kumar, Aparajita Mohanty
The ethnomedicinal values of plants form the basis of the herbal drug industry. India has contributed its knowledge of traditional system medicines (Ayurveda and Siddha) to develop herbal medicines with negligible side effects. The World Health Organization has also recognized the benefits of drugs developed from natural products. Abutilon indicum, Hibiscus sabdariffa, Sida acuta and Sida rhombifolia are ethnomedicinal plants of Malvaceae, commonly used in Indian traditional system of medicines. Traditionally these plants were used in the form of extracts/powder/paste by tribal populations of India for treating common ailments like cough and cold, fever, stomach, kidney and liver disorders, pains, inflammations, wounds, etc...
October 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29057046/synthesis-and-pharmacological-evaluation-of-selective-histone-deacetylase-6-inhibitors-in-melanoma-models
#15
Maurício T Tavares, Sida Shen, Tessa Knox, Melissa Hadley, Zsófia Kutil, Cyril Bařinka, Alejandro Villagra, Alan P Kozikowski
Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the past 30 years. In our effort to identify potent and isoform-selective histone deacetylase (HDAC) inhibitors as a therapeutic approach to melanoma, a series of new HDAC6 inhibitors based on the nexturastat A scaffold were prepared. The new analogues 4d, 4e, and 7b bearing added hydrophilic substituents, so as to establish additional hydrogen bonding on the rim of the HDAC6 catalytic pocket, exhibit improved potency against HDAC6 and retain selectivity over HDAC1...
October 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28974793/extraction-and-identification-of-bioactive-components-in-sida-cordata-burm-f-using-gas-chromatography-mass-spectrometry
#16
Mani Ganesh, Murugan Mohankumar
Sida cordata (Burm.f.) is a pineal tropical plant in the family Malvaceae that is found throughout India and used to treat various diseases and ailments in many complementary and alternative medicine systems. This study identified the bioactive components present in whole-plant ethanol extracts of S. cordata using gas chromatography-mass spectrometry (GC-MS). Based on their retention times (RT) and mass-to-charge ratios (m/z), 29 bioactive compounds were identified: nonanoic acid, vitamin D3, 3-trifluroacetoxypentadecane, α-d-glucopyranoside, O-α-d-glucopyranosyl-(1...
September 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28972732/bilayer-plots-for-accurately-determining-the-chirality-of-single-walled-carbon-nanotubes-under-complex-environments
#17
Juan Yang, Daqi Zhang, Yuecong Hu, Chenmaya Xia, Sida Sun, Yan Li
The chirality (n,m) determines all structures and properties of a single-walled carbon nanotube (SWNT), therefore, accurate and convenient (n,m) assignments are vital in nanotube-related science and technology. Previously, a so-called Kataura plot that protracts the excitonic transition energies (Eii's) of SWNTs with various (n,m) with respect to the tube diameter (dt) has been widely utilized by researchers in the nanotube community for all (n,m)-related studies. However, the facts that both Eii and the calculated dt are subject to interactions with the environments make it inconvenient to accurately determine the (n,m) under complex environments...
October 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28967199/levels-and-determinants-of-breast-and-cervical-cancer-screening-uptake-in-hiv-infected-women-compared-with-the-general-population-in-france
#18
L Tron, F Lert, B Spire, R Dray-Spira
OBJECTIVES: Cancer is a growing concern for HIV-infected people, and screening plays a major role in alleviating the burden it causes. We sought to investigate the levels and determinants of breast cancer screening (BCS) and cervical cancer screening (CCS) in HIV-infected women as compared with the general population. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study was conducted in 2011 in a national representative sample of 3022 HIV-infected hospital out-patients in France...
March 2017: HIV Medicine
https://www.readbyqxmd.com/read/28962198/analysis-of-risk-factors-for-post-operative-complications-and-prognostic-predictors-of-disease-recurrence-following-definitive-treatment-of-patients-with-esophageal-cancer-from-two-medical-centers-in-northwest-china
#19
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Evaluating the clinicopathological features of patients receiving definitive treatment for esophageal cancer may facilitate the identification of patterns and factors associated with post-operative complications, and enable the development of a surveillance strategy for surviving patients at a higher risk of disease recurrence. In the present study, clinical data from 579 patients with esophageal cancer that underwent radical resection of esophagus were collected. These patients were admitted to two medical centers in Northwest China, and information regarding the presence or absence of basic chronic diseases and post-operative results were retrospectively analyzed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28919477/influence-of-microwave-heating-on-biogas-production-from-sida-hermaphrodita-silage
#20
Marcin Zieliński, Marcin Dębowski, Paulina Rusanowska
This study compared the effects on biogas production of suspended sludge versus a combination of suspended sludge and immobilized biomass, and microwave versus convection heating. Biogas production was the highest in the hybrid bioreactor heated by microwaves (385L/kg VS) and also the most stable, as shown by the FOS/TAC ratio and pH. Regardless of the type of heating, biogas production was 8% higher with immobilized biomass than without. Although the lag phase of biogas production was shorter with microwave heating than without, the log phase was longer, and biogas production in the microwave heated bioreactors took about twice as long (ca...
December 2017: Bioresource Technology
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