Seung-Chul Pack, Hye-Ran Kim, Sang-Woo Lim, Hwan-Young Kim, Jung-Yun Ko, Ki-Sang Lee, David Hwang, Seong-Il Park, Hoon Kang, Sang-Wook Park, Gun-Young Hong, Se-Min Hwang, Myung-Geun Shin, Soong Lee
PURPOSE: The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (APC), and E-cadherin), which are known to be involved in the pathogenesis of colorectal cancer (CRC) and its clinicopathological significance. METHODS: The study subjects were 60 CRC patients, 40 patients with adenomatous colorectal polyp and 60 healthy control individuals...
January 2013: International Journal of Colorectal Disease