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https://www.readbyqxmd.com/read/28918027/adeno-associated-viral-vector-mediated-mtor-inhibition-by-short-hairpin-rna-suppresses-laser-induced-choroidal-neovascularization
#1
Tae Kwann Park, Si Hyung Lee, Jun Sub Choi, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Heuiran Lee, Steven Hyun Seung Lee, Keerang Park
Choroidal neovascularization (CNV) is the defining characteristic feature of the wet subtype of age-related macular degeneration (AMD) and may result in irreversible blindness. Based on anti-vascular endothelial growth factor (anti-VEGF), the current therapeutic approaches to CNV are fraught with difficulties, and mammalian target of rapamycin (mTOR) has recently been proposed as a possible therapeutic target, although few studies have been conducted. Here, we show that a recombinant adeno-associated virus-delivered mTOR-inhibiting short hairpin RNA (rAAV-mTOR shRNA), which blocks the activity of both mTOR complex 1 and 2, represents a promising therapeutic approach for the treatment of CNV...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28916115/-retinal-vein-occlusions
#2
REVIEW
A Pierru, J-F Girmens, E Héron, M Paques
Retinal venous occlusions comprise central retinal vein occlusion, hemiretinal vein occlusions, and branch retinal vein occlusions. They are associated with arterial hypertension and glaucoma. Retinal vein occlusions occur more frequently in males, at a median age of 55. The pathogenesis of retinal venous occlusions remains obscure. The clinical presentation of the disease is variable. In most cases, there is a unilateral visual loss over days with a painless, white and quiet eye. However, retinal venous occlusions may also present as an abrupt and profound loss of vision, or be asymptomatic...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28906472/therapeutic-effect-of-cilostazol-ophthalmic-nanodispersions-on-retinal-dysfunction-in-streptozotocin-induced-diabetic-rats
#3
Noriaki Nagai, Saori Deguchi, Hiroko Otake, Noriko Hiramatsu, Naoki Yamamoto
We previously prepared ophthalmic formulations containing cilostazol (CLZ) nanoparticles by bead mill methods (CLZnano), and found that instillation of CLZnano into rat eyes supplies CLZ into the retina. In this study, we investigated changes in the electroretinograms (ERG) of streptozotocin-induced diabetic rats (STZ rats), a model of diabetes mellitus. In addition, we demonstrated that dispersions containing CLZ nanoparticles attenuate changes in the ERG of STZ rats. The instillation of CLZnano had no effect on body weight or plasma glucose and insulin levels...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28902338/confluent-endpoint-subthreshold-argon-laser-for-serous-macular-detachment-in-tilted-disc-syndrome-refractory-to-anti-vegf
#4
Maria Fernanda Abalem, Pedro Carlos Carricondo, Helen Nazareth Veloso Dos Santos, Rafael Garcia, Cynthia X Qian, John Helal, Eduardo Cunha de Souza, Walter Yukihiko Takahashi
A 70-year-old woman presented with 20/200 visual acuity in the right eye. Multimodal imaging revealed tilted disc syndrome (TDS) with macular serous detachment (MSD) and pigmentary changes at the temporal margin of the optic disc. Subretinal fluid persisted after three monthly intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) injections and threshold focal laser photocoagulation. Subsequently, confluent subthreshold argon laser was applied over the entire area of retinal pigment epithelium (RPE) abnormalities, resulting in the resolution of subretinal fluid without recurrence through 3 years of follow-up...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28895631/-oct-angiography-of-rpe-tears-in-exudative-amd-morpohological-analysis-of-the-choriocapillaris-and-the-rpe
#5
Matthias Gutfleisch, Kai Rothaus, Marie-Louise Farecki, Henrik Faatz, Britta Heimes-Bussmann, Frederic Gunnemann, Martin Ziegler, Ioannis Papapostolou, Albrecht Lommatzsch, Daniel Pauleikoff
Background Retinal pigment epithelium (RPE) tears are a typical complication of vascular pigment epithelium detachment in age-related macular degeneration (AMD). During proactive intense anti-VEGF therapy, stabilisation or improvement of function may occur. With the new method of OCT angiography (OCT-A), retinal vessels and flow density can be quantified. This pilot study investigates changes in the choriocapillars (CC) in areas with increasing FAF in OCT following an RPE-tear. Methods In six eyes with an RPE-tear, prospectively initially and every three months thereafter, multimodal imaging was performed, including fundus autofluorescence (FAF) (HRA2, Heidelberg Engineering, Heidelberg, Deutschland) and OCT-A (RTVue XR Avanti, SSDA-Modus, Angiovue, Optovue, Freemont, CA, USA)...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28893457/-treatment-of-choroidal-noevascularization-secondary-to-angioid-streaks-with-bevacizumab-and-response-experience-of-the-ophthalmology-department-of-hassan-ii-university-hospital
#6
M El Bahloul, F Chraïbi, S Aounzou, A Salam Diarra, M Abdellaoui, I Benatiya, H Tahri
PURPOSE: To evaluate the efficacy of intravitreal bevacizumab in the treatment of choroidal neovascularization (CNV) secondary to angioid streaks. METHODS: We conducted a prospective study in the ophthalmology department of Hassan II university hospital in Fez, including 12 eyes of 7 patients with CNV associated with angioid streaks. We injected 8 eyes with bevacizumab 1.25mg; best corrected visual acuity (BCVA), fundus examination, fluorescein angiography and optical coherence tomography were performed and analyzed for all patients before and after treatment...
September 8, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28886052/comparison-of-clinical-features-and-3-month-treatment-response-among-three-different-choroidal-thickness-groups-in-polypoidal-choroidal-vasculopathy
#7
Mingui Kong, Sung Min Kim, Don-Il Ham
Eyes with polypoidal choroidal vasculopathy (PCV) were recently reported to have various choroidal thickness, and choroidal thickness might be associated with visual outcome in the treatment of many retinal disorders. The range of subfoveal choroidal thickness (SFCT), clinical features, and 3-month treatment response among three groups having different range of SFCT were investigated in PCV eyes. In 78 treatment-naïve eyes with PCV, SFCT was measured using optical coherence tomography. Eyes were classified into thin, medium, and thick groups, using mean and one standard deviation of SFCT...
2017: PloS One
https://www.readbyqxmd.com/read/28884436/effects-of-vegf-levels-on-anti-vegf-therapy-for-patients-with-idiopathic-choroidal-neovascularization
#8
Xiaojuan Fan, Ning Gao, Jingming Li, Jianqin Lei, Qianyan Kang
The objective of this study is to investigate the levels of vascular endothelial growth factor (VEGF) and other cytokines in aqueous humor of patients with idiopathic choroidal neovascularization (CNV) and their effects together with central retinal thickness (CRT) on the response to intravitreal injection of anti-VEGF antibody ranibizumab. This clinical study recruited 32 eyes from 32 patients with CNV under or besides fovea. VEGF, interleukin (IL)-6, IL-8, and monocyte chemoattractant protein (MCP)-1 levels were detected in aqueous humor (0...
September 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28881146/health-economic-evaluation-of-fluocinolone-acetonide-190%C3%A2-%C3%A2%C2%B5g-implant-in-people-with-diabetic-macular-edema
#9
Sarah E Holden, Craig J Currie, David R Owens
OBJECTIVES: To assess healthcare resource use and costs of treating people with clinically significant diabetic macular edema (DME) with fluocinolone acetonide (FAc) 190 µg intravitreal implant in routine clinical practice. METHODS: The retrospective Iluvien Clinical Evidence (ICE-UK) study collected data on people prescribed the FAc implant in any one of 13 ophthalmology centers between April 1, 2013 and April 15, 2015. Data were collected for 12 months before and after implantation...
September 7, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28866667/a-modified-technique-for-the-transconjunctival-and-sutureless-external-drainage-of-subretinal-fluid-in-bullous-exudative-retinal-detachment-using-a-24-g-i-v-catheter
#10
Jie Peng, Qi Zhang, Haiying Jin, Ping Fei, Peiquan Zhao
PURPOSE: To present the use of a 24-G Optiva® i.v. catheter for external drainage of subretinal fluid (SRF) in bullous exudative retinal detachment (RD). METHODS: Thirteen eyes with bullous exudative RD were included in our study. SRF drainage was accomplished via a transconjunctival scleral incision with a 24-G catheter followed by laser treatment, vitrectomy, or anti-VEGF treatment, as needed. Data on age, indications, visual acuities, the number of drainage times, drainage duration, complications, and fundoscopy were collected...
September 2, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28860698/the-effect-of-intravitreal-injections-on-dry-eye-and-proposed-management-strategies
#11
REVIEW
Augustinus Laude, Jimmy Wk Lim, Vishwanath Srinagesh, Louis Tong
Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents has become a commonly used treatment method for a number of ophthalmic conditions, including age-related macular degeneration. Although anti-VEGF therapy has shown promising results for many patients, there are several aspects of its application that have not been thoroughly investigated. One of these is the development and/or escalation of concurrent dry eye syndrome. Many patients undergoing treatment are already predisposed to dry eye disease due to their age and overall ocular health...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28860695/the-effect-of-vitreomacular-adhesion-in-exudative-age-related-macular-degeneration-on-the-results-of-ranibizumab-intravitreal-injection
#12
Hiroyuki Suzuki, Seita Morishita, Ryohsuke Kohmoto, Masanori Fukumoto, Takaki Sato, Teruyo Kida, Mari Ueki, Hidehiro Oku, Kimitoshi Nakamura, Tsunehiko Ikeda
PURPOSE: To investigate whether vitreomacular adhesion (VMA) affects the outcome of anti-vascular endothelial growth factor (VEGF) therapy for the treatment of exudative age-related macular degeneration (AMD) in Japanese patients. SUBJECTS AND METHODS: Of 88 Japanese AMD patients (28 men and 60 women, mean age: 72.7±7.5 years) who underwent intravitreal injection of ranibizumab for 3 years from 2010 to 2013, this study involved 12 eyes of 12 patients (10 men and two women) in whom VMA was observed based on optical coherence tomography (OCT) findings (VMA [+] group) and 17 eyes of 16 patients (seven men and nine women, control group) in whom no VMA was observed (VMA [-] group)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28840854/comment-on-licence-to-save-a-uk-survey-of-anti-vegf-use-for-the-eye-in-2015
#13
C MacGregor, C Whaley, N Maycock
No abstract text is available yet for this article.
August 25, 2017: Eye
https://www.readbyqxmd.com/read/28839510/combined-intravitreal-dexamethasone-implant-and-micropulse-yellow-laser-for-treatment-of-anti-vegf-resistant-diabetic-macular-edema
#14
Ahmed Hosni Abd Elhamid
PURPOSE: To report the efficacy and safety of combined intravitreal dexamethasone implant and micropulse laser for anti-VEGF resistant diabetic macular edema. PATIENTS AND METHODS: Prospective, non-controlled study that was conducted for twenty eyes with center-involved diabetic macular edema not responding to anti-VEGF therapy. Ozurdex intravitreal implant was injected to all eyes with subsequent micropulse yellow laser one month after the injection. All eyes were followed up after one, three, four, six, nine and twelve months...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28839470/decoding-noncoding-rnas-role-of-micrornas-and-long-noncoding-rnas-in-ocular-neovascularization
#15
REVIEW
Yan Zhang, Siwei Cai, Yurong Jia, Chen Qi, Jing Sun, Hong Zhang, Fei Wang, Yunshan Cao, Xiaorong Li
Ocular neovascularization is a pathological sequel of multiple eye diseases. Based on the anatomical site into which the abnormal neovessels grow, ocular neovascularization can be categorized into corneal neovascularization, choroidal neovascularization, and retinal neovascularization. Each category is intractable, and may lead to blindness if not appropriately treated. However, the current therapeutic modalities, including laser photocoagulation, vitrectomy surgery, and anti-VEGF drugs, raise concerns due to limited efficacy, damage on retinal parenchyma and vasculature, and the patients' unresponsiveness to the treatments...
2017: Theranostics
https://www.readbyqxmd.com/read/28837729/analyzing-and-predicting-visual-acuity-outcomes-of-anti-vegf-therapy-by-a-longitudinal-mixed-effects-model-of-imaging-and-clinical-data
#16
Wolf-Dieter Vogl, Sebastian M Waldstein, Bianca S Gerendas, Thomas Schlegl, Georg Langs, Ursula Schmidt-Erfurth
Purpose: We develop a longitudinal statistical model describing best-corrected visual acuity (BCVA) changes in anti-VEGF therapy in relation to imaging data, and predict the future BCVA outcome for individual patients by combining population-wide trends and initial subject-specific time points. Methods: Automatic segmentation algorithms were used to measure intraretinal (IRF) and subretinal (SRF) fluid volume on monthly spectral-domain optical coherence tomography scans of eyes with central retinal vein occlusion (CRVO) receiving standardized anti-VEGF treatment...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28837425/aflibercept-bevacizumab-or-ranibizumab-for-diabetic-macular-oedema-recent-clinically-relevant-findings-from-drcr-net-protocol-t
#17
Sophie Cai, Neil M Bressler
PURPOSE OF REVIEW: The aim of this study was to provide clinically relevant findings from the DRCR.net Protocol T, a multicentre randomized clinical trial comparing intravitreous aflibercept, repackaged (compounded) bevacizumab and ranibizumab for vision-impairing centre-involved diabetic macular oedema (DME). RECENT FINDINGS: At 1 year, all three antivascular endothelial growth factor (anti-VEGF) drugs, on average, improved visual acuity. There was no difference among drugs in mean change in visual acuity from baseline among eyes with baseline Snellen equivalent visual acuity of 20/32 to 20/40, whereas aflibercept yielded superior vision outcomes among eyes with baseline visual acuity of 20/50 to 20/320...
August 23, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28834972/-healthcare-research-into-anti-vegf-therapy-selection-and-methodological-precautions
#18
Focke Ziemssen, Andreas Stahl, Spyridon Dimopoulos
Health care research has emerged as an approach to assess and improve quality of care and patient outcomes in the real world. It also has the potential to reduce healthcare costs by providing evidence to guide healthcare decisions.Randomised controlled trials (RCTs) theoretically offer the ideal study design to support treatment decisions. In RCTs, randomisation (formal chance) determines treatment allocation, which prevents selection bias from distorting the parameters of anti-VEGF treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in neovascular age-related macular degeneration or diabetic macular oedema trials, which limits the validity of the results to the whole patient population seen in clinical practice...
August 23, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28832635/expression-of-the-angiogenic-mediator-angiopoietin-like-4-in-the-eyes-of-patients-with-proliferative-sickle-retinopathy
#19
Kathleen Jee, Murilo Rodrigues, Fabiana Kashiwabuchi, Brooks P Applewhite, Ian Han, Gerard Lutty, Morton F Goldberg, Gregg L Semenza, Silvia Montaner, Akrit Sodhi
The recent success of therapies directly targeting the angiogenic mediator, vascular endothelial growth factor (VEGF), for the treatment of proliferative diabetic retinopathy has encouraged clinicians to extend the use of anti-VEGF therapies for the treatment of another ischemic retinal vascular disease, proliferative sickle cell retinopathy (PSR), the most common cause of irreversible blindness in patients with sickle cell disease. However, results from case reports evaluating anti-VEGF therapies for PSR have been mixed...
2017: PloS One
https://www.readbyqxmd.com/read/28831613/sustained-intraocular-pressure-elevation-in-eyes-treated-with-intravitreal-injections-of-anti-vascular-endothelial-growth-factor-for-diabetic-macular-edema-in-a-real-life-setting
#20
S Vo Kim, F Fajnkuchen, V Sarda, L Qu-Knafo, B Bodaghi, A Giocanti-Aurégan
PURPOSE: The aim of this study was to investigate the sustained intraocular pressure (IOP) elevation after repeated anti-VEGF intravitreal injections (IVI) in patients with diabetic macular edema (DME). METHODS: A retrospective study included 140 eyes without prior glaucoma, treated with at least three anti-VEGF injections for DME between 2012 and 2016. IOP elevation was defined by an increase above baseline IOP by ≥6 mmHg. Baseline IOP was defined as the mean of IOP values before treatment initiation...
August 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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