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pregnancy induced hypertension

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https://www.readbyqxmd.com/read/27935325/decreased-baroreflex-sensitivity-is-linked-to-sympathovagal-imbalance-low-grade-inflammation-and-oxidative-stress-in-pregnancy-induced-hypertension
#1
M Subha, Pravati Pal, G K Pal, S Habeebullah, C Adithan, M G Sridhar
Pregnancy-induced hypertension (PIH) has been reported as a cardiovascular (CV) risk. We assessed the sympathovagal imbalance (SVI) and the association of inflammation and oxidative stress (OS) with CV risks in PIH. A total of 125 pregnant women having a risk factor for PIH were followed till term and the incidence of PIH was observed. Retrospectively, they were divided into two groups: Group I (those who did not develop PIH, n = 82) and Group II (those who developed PIH, n = 43). Blood pressure variability (BPV) parameters including baroreflex sensitivity (BRS), spectral heart rate variability (HRV), autonomic function tests (AFTs), inflammatory markers (interleukin-6, TNF-α, interferon-γ), and OS markers were measured in both the groups...
December 9, 2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27931584/evaluation-of-pregnancy-outcomes-after-liver-transplantation
#2
M Akarsu, T Unek, A Avcu, M Ozbilgin, T Egeli, I Astarcioglu
Liver transplantation is increasing worldwide. Pregnancy after liver transplantation is considered to be well tolerated with favorable neonatal outcomes in cases of stable and sufficient graft function. In this study, our aim was to determine pregnancy and neonatal outcomes of patients after liver transplantation. Data for patients who had been followed-up by the liver transplantation clinic at the Dokuz Eylül University Medical Faculty Hospital, Turkey, between 2002 and 2016, and who had pregnancy after the transplantation were evaluated retrospectively...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27927652/nicotinamide-ameliorates-a-preeclampsia-like-condition-in-mice-with-reduced-uterine-perfusion-pressure
#3
Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
Background - Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. Anti-hypertensives currently used for PE reduce blood pressure of PE mothers, but do not prevent pre-term delivery, and do not alleviate fetal growth restriction (FGR) associated with PE. We have recently shown that the activation of the ET system exacerbates PE. However, ET receptor antagonists are teratogenic and not suitable for pregnant women. A vitamin B3 nicotinamide (Nam) inhibits vasoconstriction by ET, is generally considered safe and harmless to babies...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27926659/macroprolactinomas-and-nonfunctioning-pituitary-adenomas-and-pregnancy-outcomes
#4
Kimberley Lambert, Kate Rees, Paul T Seed, Mandish K Dhanjal, Marian Knight, David R McCance, Catherine Williamson
OBJECTIVE: To examine the monitoring, management, and outcomes of pituitary tumors in pregnancy. METHODS: A national, prospective, observational, population-based case series study was conducted in all U.K. consultant-led obstetric units over 3 years using the U.K. Obstetric Surveillance System. To evaluate rates of adverse pregnancy outcomes, women with a macroprolactinoma (10 mm or greater) or nonfunctioning pituitary adenoma, diagnosed before or during pregnancy, were compared with two comparison groups: 1) a U...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27913562/relationship-between-maternal-hypoglycaemia-and-small-for-gestational-age-infants-according-to-maternal-weight-status-a-retrospective-cohort-study-in-two-hospitals
#5
Satoshi Shinohara, Yuzo Uchida, Mitsuo Hirai, Shuji Hirata, Kohta Suzuki
OBJECTIVE: The relationship between pre-pregnancy body mass index (BMI) and low glucose challenge test (GCT) results by maternal weight status has not been examined. This study aimed to clarify the relationship between a low GCT result and small for gestational age (SGA) by maternal weight status. DESIGN: A retrospective cohort study in 2 hospitals. SETTING: This study evaluated the obstetric records of women who delivered in a general community hospital and a tertiary perinatal care centre...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27910864/renin-angiotensin-aldosterone-system-gene-polymorphisms-in-gestational-hypertension-and-preeclampsia-a-case-control-gene-association-study
#6
Xun Li, Hongzhuan Tan, Shujin Zhou, Shimin Hu, Tianyi Zhang, Yangfen Li, Qianru Dou, Zhiwei Lai, Fenglei Chen
Pregnancy-induced hypertension (PIH, including preeclampsia [PE] and gestational hypertension [GH]) and cardiovascular diseases (CVDs) have some metabolic changes and risk factors in common. Many studies have reported associations between single nucleotide polymorphisms (SNPs) of renin-angiotensin-aldosterone system (RAAS) genes and CVDs (particularly hypertension), and their findings have provided candidate SNPs for research on genetic correlates of PIH. We explored the association between hypertension-related RAAS SNPs and PIH in a Chinese population...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903516/metabolic-abnormalities-and-obesity-s-impact-on-the-risk-for-developing-preeclampsia
#7
Frank T Spradley
Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to originate from ischemic insults in the placenta driving the release of pro-hypertensive anti-angiogenic (sFlt-1) and pro-inflammatory (TNFα) factors into the maternal circulation. While the increased incidence of PE is hypothesized to be largely due to the obesity pandemic, the mechanisms whereby obesity increases this risk are unknown...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#8
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#9
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27889763/inhibition-of-the-jak2-stat3-sosc1-signaling-pathway-improves-secretion-function-of-vascular-endothelial-cells-in-a-rat-model-of-pregnancy-induced-hypertension
#10
Jian-Ying Luo, Dan Fu, Ya-Qin Wu, Ying Gao
BACKGROUND/AIMS: The present study aimed to investigate the effects of the JAK2/STAT3/SOSC1 signaling pathway on the secretion function of vascular endothelial cells (VECs) in a rat model of pregnancy-induced hypertension (PIH). METHODS: A PIH rat model was established. Forty-eight pregnant Sprague-Dawley female rats were selected and assigned into four groups: the normal group (normal non-pregnant rats), the non-PIH group (pregnant rats without PIH), the PIH group (pregnant rats with PIH) and the AG490 group (pregnant rats with PIH treated with AG490)...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27884114/hyperemesis-gravidarum-and-placental-dysfunction-disorders
#11
Heleen M Koudijs, Ary I Savitri, Joyce L Browne, Dwirani Amelia, Mohammad Baharuddin, Diederick E Grobbee, Cuno S P M Uiterwaal
BACKGROUND: Evidence about the consequence of hyperemesis gravidarum (HG) on pregnancy outcomes is still inconclusive. In this study, we evaluated if occurrence of hyperemesis gravidarum is associated with placental dysfunction disorders and neonatal outcomes. METHODS: A prospective cohort study was conducted in a maternal and child health primary care referral center, Budi Kemuliaan Hospital and its branch, in Jakarta, Indonesia. 2252 pregnant women visiting the hospital for regular antenatal care visits from July 2012 until October 2014 were included at their first clinic visit...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27882439/obstetric-and-perinatal-outcome-of-babies-born-from-sperm-selected-by-macs-from-a-randomized-controlled-trial
#12
Laura Romany, Nicolas Garrido, Ana Cobo, Belen Aparicio-Ruiz, Vicente Serra, Marcos Meseguer
PURPOSE: The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial. METHODS: This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described...
November 23, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27862673/vitamin-d-restores-angiogenic-balance-and-decreases-tumor-necrosis-factor-%C3%AE-in-a-rat-model-of-pre-eclampsia
#13
Jing Song, Yue Li, Ruifang An
AIM: Deficiency of vitamin D is correlated with pre-eclampsia (PE), a hypertensive disorder of pregnancy, and is characterized by angiogenic imbalance and inflammation. The aim of this study was to investigate whether vitamin D supplementation can restore the angiogenic balance and ameliorate inflammation in a rat model of PE. METHODS: PE was induced using l-nitroarginine methylester. Normal pregnant and PE-induced rats were supplemented with vitamin D on gestation days 14-19...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27856999/simvastatin-alleviates-pathology-in-a-rat-model-of-preeclampsia-involving-erk-mapk-pathway
#14
Xiujuan Dong, Dandan Shi
Preeclampsia (PE) is a pregnancy-specific condition characterized by new-onset hypertension. There is evidence suggesting that imbalances of angiogenic factors, oxidative stress, and inflammation may be central to the pathogenesis of PE. We sought to investigate whether simvastatin would reduce mean arterial pressure, restore the angiogenic balance, and ameliorate inflammation and oxidative stress in a nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME)-induced rat model of PE. We found that blood pressure was significantly increased in the l-NAME group compared to normal pregnant dams (P < ...
November 16, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27854380/physiologic-adaptation-of-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#15
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the physiological pattern of gestational plasma volume adjustments during human singleton pregnancies and compare this to the pattern of pregnancies complicated by pregnancy-induced hypertension, preeclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies...
November 11, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27848226/atypical-hemolytic-uremic-syndrome-in-the-setting-of-complement-amplifying-conditions-case-reports-and-a-review-of-the-evidence-for-treatment-with-eculizumab
#16
REVIEW
Arif Asif, Ali Nayer, Christian S Haas
Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, progressive, life-threatening form of thrombotic microangiopathy (TMA) predominantly caused by dysregulation of the alternative pathway of the complement system. Complement-amplifying conditions (CACs), including pregnancy complications [preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome], malignant hypertension, autoimmune diseases, transplantation, and others, are associated with the onset of TMA in up to 69 % of cases of aHUS...
November 15, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27847698/intrathecal-midazolam-as-an-adjuvant-in-pregnancy-induced-hypertensive-patients-undergoing-an-elective-caesarean-section-a-clinical-comparative-study
#17
Ravichandra Dodawad, Sumalatha G B, Sandeep Pandarpurkar, Parashuram Jajee
BACKGROUND: A pain-free postoperative period is essential following a caesarean section so new mothers may care for and bond with their neonates. Intrathecal adjuvants are often administered during this procedure to provide significant analgesia, but they may also have bothersome side effects. Intrathecal midazolam produces effective postoperative analgesia with no significant side effects. OBJECTIVES: This prospective, randomized, double-blind study was designed to compare the analgesic efficacy and safety of intrathecal midazolam vs...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27843854/clinical-study-of-fundus-findings-in-pregnancy-induced-hypertension
#18
Rahul Navinchandra Bakhda
BACKGROUND AND OBJECTIVES: To study the role of ophthalmoscopy in pregnancy induced hypertension (PIH) in diagnosis, prognosis, differential diagnosis, line of treatment and effect of treatment. MATERIALS AND METHODS: An observational study in which all the patients for the study are selected from antenatal clinic, antenatal wards and preeclampsia and eclampsia room in Department of Obstetrics and Gynecology, General Ophthalmic Out Patient Department (OPD) in case of ambulatory patients, during the period of Nov...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843354/postpartum-hemorrhage-incidence-risk-factors-and-outcomes-in-a-low-resource-setting
#19
Solwayo Ngwenya
BACKGROUND: Primary postpartum hemorrhage (PPH) is defined as blood loss from the genital tract of 500 mL or more following a normal vaginal delivery (NVD) or 1,000 mL or more following a cesarean section within 24 hours of birth. PPH contributes significantly to maternal morbidity and mortality worldwide. Women can rapidly hemorrhage and die soon after giving birth. It can be a devastating outcome to many young families. Women giving birth in low-resource settings are at a higher risk of death than their counterparts in resource-rich environments...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27818235/high-sucrose-intake-during-gestation-increases-angiotensin-ii-type-1-receptor-mediated-vascular-contractility-associated-with-epigenetic-alterations-in-aged-offspring-rats
#20
Lei Wu, Aiping Shi, Di Zhu, Le Bo, Yuan Zhong, Juan Wang, Zhice Xu, Caiping Mao
Accruing evidence have confirmed that the fetal programming in response to adverse environmental in utero factors plays essential roles in the pathogenesis of hypertension in later life. High sugar intake has been accepted worldwide in everyday life diet and becomes the critical public health issue. Our previous studies indicated that intake of high sucrose (HS) during pregnancy could change the vascular reactivity and dipsogenic behavior closely associated with abnormal renin-angiotensin system (RAS), to increase the risk of hypertension in adult offspring...
December 2016: Peptides
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