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https://www.readbyqxmd.com/read/28525905/the-effect-of-pre-pregnancy-body-mass-index-and-excessive-gestational-weight-gain-on-the-risk-of-gestational-diabetes-in-advanced-maternal-age
#1
Beibei Dong, Hong Yu, Qiong Wei, Mengmeng Zhi, Chunhua Wu, Xiangyun Zhu, Ling Li
BACKGROUND AND PURPOSE: With the popularization of a two-child policy in China, the number of pregnant women of advanced maternal age will increase steadily. We aimed to assess the association between pre-pregnancy body mass index (BMI) and weight gain in the first and second trimester and the risk of gestational diabetes (GDM) in the advanced maternal age group and control group defined as maternal age of 20-35 years. RESULTS: The risk of GDM for obesity before pregnancy was 2...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28525825/what-is-to-blame-for-postnatal-pelvic-floor-dysfunction-in-primiparous-women-pre-pregnancy-or-intrapartum-risk-factors
#2
Constantin M Durnea, Ali S Khashan, Louise C Kenny, Uliana A Durnea, James C Dornan, Suzanne M O'Sullivan, Barry A O'Reilly
BACKGROUND: The aetiology of pelvic floor dysfunction (PFD) is still poorly understood. However childbearing is recognized as a major risk factor. OBJECTIVES: To elucidate the natural history of PFD by investigating the impact of the mode of delivery on postnatal pelvic floor dysfunction in primiparas, when PFD existing before the first pregnancy is taken into consideration. STUDY DESIGN: 4P-study (Prevalence and Predictors of Pelvic floor dysfunction in Primips) is a prospective cohort study, nested within the Screening for Pregnancy Endpoints (SCOPE) study set in a tertiary referral teaching hospital with 9000 deliveries annually...
April 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28524735/predictors-of-gestational-weight-gain-among-chilean-pregnant-women-the-chilean-maternal-and-infant-nutrition-cohort-study
#3
Maria Luisa Garmendia, Susana Mondschein, Omar Matus, Ruth Murrugarra, Ricardo Uauy
We identified factors associated with gestational weight gain (GWG) in 1,654 Chilean pregnant women with full-term pregnancies. At baseline, we collected information about sociodemographic, gyneco-obstetric, anthropometric, and health care-related factors. We found that pre-pregnancy nutritional body mass index (BMI) was the most important factor related to GWG above recommendations (overweight: RRR = 2.31, 95% CI (1.73, 3.09) and obesity: RRR = 2.90, 95% CI (2.08, 4.03)). We believe that women who are overweight/obese at the beginning of pregnancy should be identified because of their higher risk and that adequate strategies should be designed and implemented to help them achieve a healthy GWG...
May 19, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28522319/association-between-gestational-weight-gain-and-perinatal-outcomes-in-women-with-chronic-hypertension
#4
Lynn M Yee, Aaron B Caughey, Yvonne W Cheng
BACKGROUND: Gestational weight gain above or below the 2009 Institute of Medicine guidelines has been associated with adverse maternal and neonatal outcomes. Although it has been well established that excess gestational weight gain is associated with the development of gestational hypertension and preeclampsia, the relationship between gestational weight gain and adverse perinatal outcomes among women with pregestational (chronic) hypertension is less clear. OBJECTIVE: The objective of this study was to examine the relationship between gestational weight gain above and below IOM guidelines and perinatal outcomes in a large, population-based cohort of women with chronic hypertension...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28522317/the-association-between-cytochrome-p450-3a-progesterone-receptor-polymorphisms-plasma-17-ohpc-concentrations-and-spontaneous-preterm-birth
#5
Martha L Bustos, Steve N Caritis, Kathleen A Jablonski, Uma M Reddy, Yoram Sorokin, John M Thorp, Michael W Varner, Ronald J Wapner, Jay D Iams, Marshall W Carpenter, Alan M Peaceman, Brian M Mercer, Anthony Sciscione, Dwight J Rouse, Susan M Ramin
BACKGROUND: Infants born before 37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children under 5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-hydroxyprogesterone caproate (17-OHPC) reduces preterm birth by 33% in women with history spontaneous preterm birth (SPTB). We demonstrated previously that plasma concentrations of 17-OHPC vary widely among pregnant women and that women with 17-OHPC plasma concentrations in the lowest quartile had SPTB rates of 40% vs rates of 25% in those women with higher concentrations...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28514885/poorer-maternal-diet-quality-and-increased-birth-weight
#6
Madeline Grandy, Jonathan M Snowden, Janne Boone-Heinonen, Jonathan Q Purnell, Kent L Thornburg, Nicole E Marshall
OBJECTIVE: Maternal diet and gestational weight gain (GWG) influence birth weight and infant adiposity, which are important predictors of lifetime health. To better understand these relationships, we studied associations between maternal diet and GWG, adiposity, and birth weight in a well characterized cohort of pregnant women. STUDY DESIGN: Data were obtained from 41 term (>37 weeks), uncomplicated, singleton pregnancies according to pre-pregnancy BMI categories of normal (n = 11), overweight (n = 15), or obese (n = 15)...
May 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28512991/is-parity-a-risk-factor-for-excessive-weight-gain-during-pregnancy-and-postpartum-weight-retention-a-systematic-review-and-meta-analysis
#7
REVIEW
B Hill, H Bergmeier, S McPhie, M Fuller-Tyszkiewicz, H Teede, D Forster, B E Spiliotis, A P Hills, H Skouteris
The aim of this study was to systematically review and meta-analyse the associations between parity, pre-pregnancy body mass index (BMI), gestational weight gain (GWG) and, when included, postpartum weight retention (PPWR). Papers reporting associations between parity and BMI and/or GWG in adult women were eligible: 2,195 papers were identified, and 41 longitudinal studies were included in the narrative synthesis; 17 studies were included in a meta-analysis. Findings indicated that parity was associated positively with pre-pregnancy BMI...
May 17, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28507607/gene-variants-in-the-fto-gene-are-associated-with-adiponectin-and-tnf-alpha-levels-in-gestational-diabetes-mellitus
#8
Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega, Arturo Zarate
BACKGROUND: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28502760/patterns-of-gestational-weight-gain-and-birthweight-outcomes-in-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development-fetal-growth-studies-singletons-a-prospective-study
#9
Sarah J Pugh, Paul S Albert, Sungduk Kim, William Grobman, Stefanie N Hinkle, Roger B Newman, Deborah A Wing, Katherine L Grantz
BACKGROUND: Inadequate or excessive total gestational weight gain is associated with increased risks of small- and large-for-gestational-age births, respectively, but evidence is sparse regarding overall and trimester-specific patterns of gestational weight gain in relation to these risks. Characterizing the interrelationship between patterns of gestational weight gain across trimesters can reveal whether the trajectory of gestational weight gain in the first trimester sets the path for gestational weight gain in subsequent trimesters, thereby serving as an early marker for at-risk pregnancies...
May 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28495266/maternal-pre-pregnancy-infection-with-hepatitis-b-virus-and-the-risk-of-preterm-birth-a-population-based-cohort-study
#10
Jue Liu, Shikun Zhang, Min Liu, Qiaomei Wang, Haiping Shen, Yiping Zhang
BACKGROUND: Preterm birth is the leading cause of child death in children younger than 5 years. Large cohort studies in developed countries have shown that maternal hepatitis B virus infection is associated with preterm birth, but there is little reliable evidence from China and other developing countries, where hepatitis B virus prevalence is intermediate or high. Hence, we designed this study to investigate the association between pre-pregnancy hepatitis B virus infection and risk of preterm and early preterm birth...
June 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28493861/maternal-pre-pregnancy-obesity-and-neuropsychological-development-in-pre-school-children-a-prospective-cohort-study
#11
Maribel Casas, Joan Forns, David Martínez, Mònica Guxens, Ana Fernandez-Somoano, Jesus Ibarluzea, Nerea Lertxundi, Mario Murcia, Marisa Rebagliato, Adonina Tardon, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Maternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear if intrauterine or confounding factors drive this association. METHODS: We assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children's Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test...
May 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28491125/indirect-maternal-deaths-uk-and-global-perspectives
#12
Manisha Nair, Catherine Nelson-Piercy, Marian Knight
Indirect maternal deaths outnumber direct deaths due to obstetric causes in many high-income countries, and there has been a significant increase in the proportion of maternal deaths due to indirect medical causes in low- to middle-income countries. This review presents a detailed analysis of indirect maternal deaths in the UK and a perspective on the causes and trends in indirect maternal deaths and issues related to care in low- to middle-income countries. There has been no significant decrease in the rate of indirect maternal deaths in the UK since 2003...
March 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28486003/placental-lipoprotein-lipase-dna-methylation-alterations-are-associated-with-gestational-diabetes-and-body-composition-at-5%C3%A2-years-of-age
#13
Valérie Gagné-Ouellet, Andrée-Anne Houde, Simon-Pierre Guay, Patrice Perron, Daniel Gaudet, Renée Guérin, Jean-Patrice Baillargeon, Marie-France Hivert, Diane Brisson, Luigi Bouchard
Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming. The aims of this study were to assess whether placental DNA methylation (DNAm) marks were associated with maternal GDM status and to offspring body composition at 5 years old in a prospective birth cohort. DNAm levels were measured in the fetal side of the placenta in 66 samples (24 from GDM mothers) using bisDNA-pyrosequencing...
May 9, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28485827/correlation-between-pre-pregnancy-body-mass-index-and-maternal-visceral-adiposity-with-fetal-biometry-during-the-second-trimester
#14
Karina Rm Lopes, Alex Sandro R Souza, José N Figueiroa, João Guilherme B Alves
OBJECTIVE: To determine the correlation between pre-pregnancy body mass index (BMI) and maternal visceral adiposity with fetal biometry during the second trimester. METHODS: A cross-sectional observational study was conducted among pregnant women who received prenatal care at a center in Recife, Brazil, between October 3, 2011, and September 27, 2013. Pre-pregnancy BMI was determined at the first prenatal care visit. Maternal visceral adiposity and fetal biometry were measured at the same ultrasonography session...
May 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28483022/expression-of-disrupted-in-schizophrenia-1-in-hippocampus-in-postpartum-depression-animal-models-induced-by-pre-pregnancy-stress
#15
Baomei Xia, Chang Chen, Hailou Zhang, Xin Zhou, Weiwei Tao, Haoxin Wu, Gang Chen
Objective To establish a postpartum depression animal model induced by pre-pregnancy stress,assess abnormal maternal depressive-like behavior,observe the expression of disrupted-in-schizophrenia 1 (DISC1) in the hippocampus,and detect serum estradiol and corticosterone.Methods A total of 32 female Balb/c were assigned to two groups using random number table:the control group and the pre-pregnancy stressed group(model group),and the model group was subjected to 3 weeks of chronic restraint stress. After the last stressor,the control group and the model group were housed with a male...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28482752/childhood-family-structure-and-women-s-adult-overweight-risk-a-longitudinal-study
#16
M Pia Chaparro, Xavier de Luna, Jenny Häggström, Anneli Ivarsson, Urban Lindgren, Karina Nilsson, Ilona Koupil
AIM: The aim of this study was to investigate whether women's adult overweight and obesity risk was associated with their childhood family structure, measured as their mothers' marital status history, during the women's first 18 years of life. METHODS: Using linked register data, we analyzed 30,584 primiparous women born in Sweden in 1975 who were between 19-35 years of age when their height and pre-pregnancy weight was recorded. The outcomes were women's overweight/obesity (body mass index (BMI) ≥ 25 kg/m(2)) and obesity (BMI ≥ 30 kg/m(2)) and the predictor was mothers' marital status history, which was summarized using sequence analysis...
May 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28481961/healthy-lifestyle-during-early-pregnancy-and-risk-of-gestational-diabetes-mellitus
#17
Sylvia E Badon, Daniel A Enquobahrie, Paige D Wartko, Raymond S Miller, Chunfang Qiu, Bizu Gelaye, Tanya K Sorensen, Michelle A Williams
Previous studies have found associations between individual healthy behaviors and reduced risk of gestational diabetes mellitus (GDM); however, the association of composite healthy lifestyle during pregnancy with GDM has not been examined. Participants (n = 3,005) in the Omega study, a pregnancy cohort in Washington State (1996-2008), reported diet, physical activity, smoking, and stress during early pregnancy. Lifestyle components were dichotomized into healthy/unhealthy, then combined into a total lifestyle score (0-4)...
May 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28472224/new-models-of-pregnancy-associated-hypertension
#18
Spencer C Cushen, Styliani Goulopoulou
Pregnancy-associated hypertensive disorders are leading causes of maternal and fetal mortality. These include: pre-pregnancy hypertension that persists throughout gestation (chronic/preexisting hypertension), de novo hypertension that is diagnosed after 20 weeks of gestation and resolves after birth (gestational hypertension), de novo hypertension that is diagnosed after 20 weeks of gestation with or without proteinuria and end-organ damage (preeclampsia and eclampsia), and chronic hypertension with superimposed preeclampsia during gestation...
May 2, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28467232/influence-of-pre-pregnancy-leisure-time-physical-activity-on-gestational-and-postpartum-weight-gain-and-birth-weight-a-cohort-study
#19
Hanne Kristine Hegaard, Line Rode, Malene Kjær Katballe, Henning Langberg, Bent Ottesen, Peter Damm
In order to examine the association between pre-pregnancy leisure time physical activities and gestational weight gain, postpartum weight gain and birth weight, we analysed prospectively collected data from 1827 women with singleton term pregnancies. Women were categorised in groups of sedentary women, light exercisers, moderate exercisers and competitive athletes. The results showed that sedentary women on average gained 14.1 kg during pregnancy, whereas light exercisers gained 13.7 kg, moderate exercisers gained 14...
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28455087/assessing-the-potential-impact-of-extending-antenatal-steroids-to-the-late-preterm-period
#20
Vivienne Souter, Ellen Kauffman, Ms Alice J Marshall, Jodie G Katon
BACKGROUND: In 2016 guidance statements were issued by the Society for Maternal Fetal Medicine and by the American College of Obstetricians and Gynecologists about extending antenatal steroid use to selected late preterm singleton pregnancies. OBJECTIVE: To review antenatal steroid use prior to the 2016 guidance statements and assess the potential impact of these. STUDY DESIGN: This cohort study used chart-abstracted data from singleton deliveries from January 1, 2012 to March 31, 2016 at 12 centers participating in the Obstetrics Clinical Outcomes Assessment Program, a quality initiative in Washington State...
April 25, 2017: American Journal of Obstetrics and Gynecology
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