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https://www.readbyqxmd.com/read/29706030/preconception-management-of-thyroid-dysfunction
#1
Onyebuchi E Okosieme, Ishrat Khan, Peter N Taylor
Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and maternal health. The early gestation period is one of critical fetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Preconception planning in women with hypothyroidism should pre-empt and mirror the adaptive changes of the thyroid gland by careful levothyroxine dose adjustments to ensure adequate fetal thyroid hormone delivery in pregnancy...
April 29, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29684405/moderate-perinatal-thyroid-hormone-insufficiency-alters-visual-system-function-in-adult-rats
#2
William K Boyes, Laura Degn, Barbara Jane George, Mary E Gilbert
Thyroid hormone (TH) is critical for many aspects of neurodevelopment and can be disrupted by a variety of environmental contaminants. Sensory systems, including audition and vision are vulnerable to TH insufficiencies, but little data are available on visual system development at less than severe levels of TH deprivation. The goal of the current experiments was to explore dose-response relations between graded levels of TH insufficiency during development and the visual function of adult offspring. Pregnant Long Evans rats received 0 or 3 ppm (Experiment 1), or 0, 1, 2, or 3 ppm (Experiment 2) of propylthiouracil (PTU), an inhibitor of thyroid hormone synthesis, in drinking water from gestation day (GD) 6 to postnatal day (PN) 21...
April 20, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29540085/higher-levels-of-thyrotropin-in-pregnancy-and-adverse-pregnancy-outcomes
#3
Tatjana Barišić, Vjekoslav Mandić, Anja Vasilj, Dejan Tiric
OBJECTIVE: To determine the frequency of subclinical hypothyroidism in women with pathological pregnancies and the association between elevated thyroid-stimulating hormone (TSH) and pregnancy outcome. SUBJECTS AND METHODS: A cross-sectional prospective study investigated value of TSH and free thyroxine (FT4) in (1) pregnant women with hypertension (HTA) (N = 62) or preeclampsia (PE) (N = 50), (2) women with gestational diabetes mellitus (GDM) (N = 92) in pregnancy, and (3) women with normal pregnancies (control) (N = 201)...
March 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29500308/developmental-milestones-at-one-year-for-the-offspring-of-mothers-with-congenital-hypothyroidism-a-population-based-study
#4
Juliane Léger, Anne Forhan, Sophie Dos Santos, Béatrice Larroque, Emmanuel Ecosse, Marie-Aline Charles, Barbara Heude
OBJECTIVE: Maternal thyroid dysfunction during pregnancy is associated with neurodevelopmental impairment in the offspring. No data are currently available for the offspring of patients treated early for congenital hypothyroidism (CH). The aim of this study was to investigate motor and language milestones at one year of age in a population-based registry of children born to young women with CH. DESIGN AND METHODS: We assessed 110 children born to mothers with CH, and 1367 children from the EDEN French population-based birth cohort study prospectively, at the age of one year, with identical questionnaires...
May 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29463525/maternal-thyroid-function-and-child-educational-attainment-prospective-cohort-study
#5
Scott M Nelson, Caroline Haig, Alex McConnachie, Naveed Sattar, Susan M Ring, George D Smith, Debbie A Lawlor, Robert S Lindsay
OBJECTIVE: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. DESIGN: Prospective cohort study. SETTING: Avon Longitudinal Study of Parents and Children cohort in the UK. PARTICIPANTS: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). EXPOSURES: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function...
February 20, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29434692/gestational-age-not-transient-hyperthyrotropinemia-impacts-brain-white-matter-diffusion-tensor-imaging-in-premature-infants
#6
Pi-Lien Hung, Chun-Chung Lui, Chen-Chang Lee, Yin-Hsiu Chien, Feng-Shun Chen, Chih-Cheng Chen, Hong-Ren Yu, Mei-Yung Chung, Li-Tung Huang
Transient hypothyroidism is common in premature infants and increases the risk of adverse neurodevelopmental outcomes. Thyroid hormone (TH) is involved in oligodendrocyte development and myelination, however, whether transient hypothyroidism is associated with oligodendrocyte dysplasia and abnormal myelination is unclear. The aim of the present study was to investigate correlations among TH levels, neurodevelopmental outcomes and white matter (WM) microstructure in premature infants. The authors designed a cohort study recruiting 81 premature infants (age, 23-35 weeks)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29385933/gestational-impaired-glucose-tolerance-gigt-induced-suppression-of-fetal-thyroid-secretion-effect-on-fetal-outcome
#7
Suganya Shanmugam, Pooja Dhiman, Soundravally Rajendiran, Archana Nimesh, Dilip Kumar Maurya
INTRODUCTION: Gestational impaired glucose tolerance (GIGT) is a milder form of gestational diabetes mellitus (GDM), which is often poorly managed. Although, GDM is known to be associated with increased incidence of thyroid dysfunction, no study has been done to study the effect of GIGT on thyroid status and its effect on fetal outcome. Here, we carried out a study to assess thyroid function and glycemic status in both maternal and cord blood of the subjects with GIGT, and to find their association with the fetal outcome...
January 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29286511/cerebral-impact-of-prenatal-irradiation-by-131i-an-experimental-model-of-clinical-neuroradioembryological-effects
#8
V V Talko, K M Loganovsky, I P Drozd, Ye V Tukalenko, T K Loganovska, S Yu Nechayev, S V Masiuk, Ye M Prokhorova
Human brain in prenatal period is a most vulnerable to ionizing radiation body structure. Unlike atomic bombings or radiological interventions in healthcare leading at most to external irradiation the intensive internal exposure may occur upon nuclear reactor accidents followed by substantial release and fallout of radioactive 131I. The latter can lead to specific neuroradioembryological effects. OBJECTIVE: To create an experimental model of prenatal cerebral radiation effects of 131I in human and to determine the experimental and clinical neuroradioembryological effects...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29175438/gestational-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-disrupts-fetoplacental-unit-fetal-thyroid-cytokines-dysfunction
#9
R G Ahmed, A W El-Gareib, H M Shaker
Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40μg/kgb.wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20...
January 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29074717/2-chlorhexidine-70-isopropyl-alcohol-versus-10-povidone-iodine-for-insertion-site-cleaning-before-central-line-insertion-in-preterm-infants-a-randomised-trial
#10
RANDOMIZED CONTROLLED TRIAL
Emily A Kieran, Anne O'Sullivan, Jan Miletin, Anne R Twomey, Susan J Knowles, Colm Patrick Finbarr O'Donnell
OBJECTIVE: To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants. DESIGN: Randomised controlled trial. SETTING: Two neonatal intensive care units (NICUs). PATIENTS: Infants <31 weeks' gestation who had a CVC inserted...
March 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29067240/benign-thyroid-disease-in-pregnancy-a-state-of-the-art-review
#11
REVIEW
Efterpi Tingi, Akheel A Syed, Alexis Kyriacou, George Mastorakos, Angelos Kyriacou
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/28993437/thyroid-hormone-regulates-protease-expression-and-activation-of-notch-signaling-in-implantation-and-embryo-development
#12
Diletta Piccirilli, Enke Baldini, Micol Massimiani, Antonella Camaioni, Antonietta Salustri, Roberta Bernardini, Marco Centanni, Salvatore Ulisse, Costanzo Moretti, Luisa Campagnolo
A clinical association between thyroid dysfunction and pregnancy complications has been extensively reported; however, the molecular mechanisms through which TH might regulate key events of pregnancy have not been elucidated yet. In this respect, we performed in vivo studies in MMI-induced hypothyroid pregnant mice, evaluating the effect of hypothyroidism on the number of implantation sites, developing embryos/resorptions and pups per litter, at 4.5, 10.5, 18.5 days post-coitum (dpc) and at birth. We also studied the expression of major molecules involved in implantation and placentation, such as the proteases ISPs, MMPs, TIMPs and Notch pathway-related genes...
January 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/28982961/mechanisms-in-endocrinology-maternal-thyroid-dysfunction-during-pregnancy-and-behavioural-and-psychiatric-disorders-of-children-a-systematic-review
#13
REVIEW
Dagnachew Muluye Fetene, Kim S Betts, Rosa Alati
BACKGROUND: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders. METHODS: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28982017/incidence-of-subclinical-hypothyroidism-and-hypothyroidism-in-early-pregnancy
#14
Frida Hosseini Akram, Bengt Johansson, Gunnar Möllerström, Britt-Marie Landgren, Anneli Stavreus-Evers, Lottie Skjöldebrand-Sparre
BACKGROUND: Untreated and subclinical hypothyroidism (SCH) has been associated with adverse pregnancy complications such as increased risk of miscarriage, hypertension, preeclampsia, and preterm delivery. However, in Sweden, screening for thyroid dysfunction during pregnancy is only recommended for women with a high risk of thyroid disease. Therefore, the aim of this study was to determine the incidence of clinical and SCH in women in the first trimester of pregnancy. MATERIALS AND METHODS: In this prospective study, 1298 pregnant women were divided into three groups: one unselected general screening group (n = 611), one low-risk group comprising women without risk factors for thyroid disorder (n = 511), and one high-risk group comprising women with an inheritance or suspicion of thyroid disease or undergoing treatment for thyroid disease (n = 88)...
November 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28945847/maternal-thyroid-antibodies-associates-with-cardiometabolic-risk-factors-in-children-at-the-age-of-16
#15
Anna-Leena Heikkinen, Fanni Päkkilä, Anna-Liisa Hartikainen, Marja Vääräsmäki, Tuija Männistö, Eila Suvanto
Context and Objective: The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children. Design, Setting, and Participants: This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#16
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetric outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: The purpose of this study was to examine the association between prepregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery, gestational diabetes mellitus, and preeclampsia. STUDY DESIGN: We conducted a secondary analysis of a prospective cohort of 18- to 40-year-old women with 1-2 previous pregnancy losses (n=1193) who participated in a multicenter randomized, placebo-controlled trial of low-dose aspirin...
December 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28825764/systemic-sclerosis-exploring-the-potential-interplay-between-thyroid-disorders-and-pregnancy-outcome-in-an-italian-cohort
#17
Paola Triggianese, Paola Conigliaro, Maria Sole Chimenti, Carmen Barbato, Elisabetta Greco, Barbara Kroegler, Caterina De Carolis, Roberto Perricone
BACKGROUND: Evidence has shown that pregnancy failure (PF) in women with systemic sclerosis (SSc) consists mainly of preterm delivery (PD) and intrauterine growth restriction (IUGR). Thyroid dysfunction (TD) and Hashimoto's thyroiditis (HT) represent a common feature of SSc. Since TD has been associated with PF, its presence in SSc women may potentially affect pregnancy outcome. OBJECTIVES: To analyze the interplay between TD and PF in a cohort of SSc women. METHODS: SSc women (n=77) and age-matched controls from the general obstetric population (n=50) were included...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28713331/thyroid-stimulating-hormone-receptor-antibodies-in-pregnancy-clinical-relevance
#18
REVIEW
Ines Bucci, Cesidio Giuliani, Giorgio Napolitano
Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular and functional properties and are subdivided into activating (TSAbs), blocking (TBAbs), or neutral (N-TRAbs) depending on their effect on TSHR...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28660410/effect-of-fetal-hypothyroidism-on-myomir-network-and-its-target-gene-expression-profiles-in-heart-of-offspring-rats
#19
Nasibeh Yousefzadeh, Sajad Jeddi, Rafighe Ghiasi, Mohammad Reza Alipour
Thyroid hormone deficiency during fetal life (fetal hypothyroidism) causes intrauterine growth restriction (IUGR). Fetal hypothyroidism (FH) could attenuate normal cardiac functions in the later life of the offspring rats. The aim of this study was to evaluate the contribution of myomiR network and its target gene expression in cardiac dysfunction in fetal hypothyroid rats. Six Pregnant female rats were divided into two groups: Control consumed tap water, and the hypothyroid group received water containing 0...
December 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28557747/supplemental-iodide-for-preterm-infants-and-developmental-outcomes-at-2-years-an-rct
#20
Fiona L R Williams, Simon Ogston, Robert Hume, Jennifer Watson, Kayleigh Stanbury, Peter Willatts, Anita Boelen, Edmund Juszczak, Peter Brocklehurst
BACKGROUND: The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of preterm infants improves neurodevelopment. METHODS: A randomized controlled trial of iodide supplementation versus placebo in infants <31 weeks' gestation...
May 2017: Pediatrics
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