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https://www.readbyqxmd.com/read/29781878/hiv-1-proviral-sequence-and-treatment-outcome-of-virologically-suppressed-patients-switching-to-coformulated-elvitegravir-cobicistat-emtricitabine-tenofovir-disoproxil-fumarate
#1
Kristen Andreatta, Silvia Chang, Ross Martin, Rima Kulkarni, Martin Daeumer, Alexander Thielen, Michael D Miller, Kirsten L White
No abstract text is available yet for this article.
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29779165/the-association-of-statin-therapy-with-incident-diabetes-evidence-mechanisms-and-recommendations
#2
REVIEW
A Agarwala, S Kulkarni, T Maddox
PURPOSE OF REVIEW: Recent studies have demonstrated a higher risk of incident diabetes associated with statin use, causing concern among patients and clinicians. In this review, we will assess the evidence and proposed mechanisms behind statin therapy and its association with incident diabetes. We will then review the current recommendations for statin use in light of this association and suggest next steps for clinicians managing these patients and researchers exploring this phenomenon...
May 19, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29778580/editorial-comment
#3
Sanjay Balwant Kulkarni
No abstract text is available yet for this article.
May 17, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29777468/van-wyk-grumbach-syndrome-a-rare-consequence-of-hypothyroidism
#4
Pavan Reddy, Kritika Tiwari, Abhishek Kulkarni, Ketan Parikh, Raju Khubchandani
Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed...
May 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29772649/pulmonary-arterial-hypertension-pathophysiology-and-treatment
#5
REVIEW
Norris S H Lan, Benjamin D Massam, Sandeep S Kulkarni, Chim C Lang
Pulmonary arterial hypertension (PAH), the first category of pulmonary hypertension, is a chronic and progressive disorder characterised by angioproliferative vasculopathy in the pulmonary arterioles, leading to endothelial and smooth muscle proliferation and dysfunction, inflammation and thrombosis. These changes increase pulmonary vascular resistance and subsequent pulmonary arterial pressure, causing right ventricular failure which leads to eventual death if untreated. The management of PAH has advanced rapidly in recent years due to improved understanding of the condition's pathophysiology, specifically the nitric oxide, prostacyclin-thromboxane and endothelin-1 pathways...
May 16, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29771360/patient-and-treatment-characteristics-by-infecting-organism-in-cerebrospinal-fluid-shunt-infection
#6
Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis N Shannon, Mandeep Tamber, John C Wellons Iii, William E Whitehead, Nicole Mayer-Hamblett
Background: Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, stratified by infecting organism subgroups outlined in the 2017 Infectious Disease Society of America's (IDSA) guidelines. Methods: We studied a prospective cohort of children <18 years of age undergoing treatment for first CSF shunt infection at one of 7 Hydrocephalus Clinical Research Network hospitals from April 2008 to December 2012...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29766281/sex-and-gender-differences-in-schizophrenic-psychoses-a-critical-review
#7
Anita Riecher-Rössler, Surina Butler, Jayashri Kulkarni
Many sex and gender differences in schizophrenic psychoses have been reported, but few have been soundly replicated. A stable finding is the later age of onset in women compared to men. Gender differences in symptomatology, comorbidity, and neurocognition seem to reflect findings in the general population. There is increasing evidence for estrogens being psychoprotective in women and for hypothalamic-pituitary-gonadal dysfunction in both sexes.More methodologically sound, longitudinal, multi-domain, interdisciplinary research investigating both sex (biological) and gender (psychosocial) factors is required to better understand the different pathogenesis and etiologies of schizophrenic psychoses in women and men, thereby leading to better tailored treatments and improved outcomes...
May 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29764948/inducible-lung-epithelial-resistance-requires-multisource-reactive-oxygen-species-generation-to-protect-against-viral-infections
#8
Carson T Kirkpatrick, Yongxing Wang, Miguel M Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleón García, Alexandria K Plumer, Vikram V Kulkarni, Hayden H Ware, Fahad Gulraiz, Miguel A Chavez Cavasos, Gabriela Martinez Zayes, Shradha Wali, Andrew P Rice, Hongbing Liu, James M Tour, William K A Sikkema, Ana S Cruz Solbes, Keith A Youker, Michael J Tuvim, Burton F Dickey, Scott E Evans
Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via inhalation of synergistically acting Toll-like receptor (TLR) agonists protects mice broadly against pneumonia, including otherwise-lethal viral infections, providing a potential opportunity to mitigate infectious threats. As intact lung epithelial TLR signaling is required for the inducible resistance and as these cells are the principal targets of many respiratory viruses, the capacity of lung epithelial cells to be therapeutically manipulated to function as autonomous antiviral effectors was investigated...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29762770/carcass-and-meat-quality-characterization-of-indigenous-and-improved-variety-of-chicken-genotypes
#9
Suresh K Devatkal, Mangalathu R Vishnuraj, Vivek V Kulkarni, Talapaneni Kotaiah
A study was conducted to examine four genotypes of chicken for their carcass and meat quality characteristics. From each genotype, 20 birds were slaughtered at their respective age of maturity. Breast and thigh muscles were evaluated for meat quality characteristics. Transport loss and carcass weight were highest in the white commercial broiler (WBR) and lowest in Aseel (ASL) and Indbro Aseel (ASR). Dressing percentage ranged between 66.41 and 72.56 and was not significantly different among genotypes. The yield of various cut-up parts for different genotypic birds was significantly different (P < 0...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29762161/anti-hiv-igm-protects-against-mucosal-shiv-transmission
#10
Siqi Gong, Khamis Tomusange, Viraj Kulkarni, Opeyemi S Adeniji, Samir K Lakhashe, Dinesh Hariraju, Amanda Strickland, Elizabeth Plake, Patrice A Frost, Sarah J Ratcliffe, Liping Wang, Eileen M Lafer, Ruth M Ruprecht
OBJECTIVE: Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory IgM. We sought to investigate for the first time the role of IgM in preventing AIDS virus acquisition in vivo. DESIGN: Recombinant polymeric monoclonal IgM was generated from the neutralizing monoclonal IgG1 antibody 33C6-IgG1, tested in vitro, and given by passive intrarectal (i...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29762048/theranostics-of-prostate-cancer-from-molecular-imaging-to-precision-molecular-radiotherapy-targeting-the-prostate-specific-membrane-antigen
#11
Harshad R Kulkarni, Aviral Singh, Thomas Langbein, Christiane Schuchardt, Dirk Mueller, Jingjing Zhang, Coline Lehmann, Richard P Baum
Alterations at the molecular level are a hallmark of cancer. Prostate cancer is associated with the overexpression of prostate specific membrane antigen (PSMA) in a majority of cases, predominantly in advanced tumors, increasing with the grade or Gleason's score. PSMA can be selectively targeted using radiolabelled PSMA ligands. These small molecules binding the PSMA can be radiolabelled with gamma-emitters like 99m Tc and 111 In or positron emitters like 68 Ga and 18 F for diagnosis as well as with their theranostic pairs such as 177 Lu (beta-emitter) or 225 Ac (alpha-emitter) for therapy...
May 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29761645/redox-guided-small-molecule-antimycobacterials
#12
REVIEW
Amogh Kulkarni, Ajay Kumar Sharma, Harinath Chakrapani
The emergence of drug resistance has posed a major challenge to treatment of tuberculosis worldwide. The new drug candidates in the pipeline are few and therefore there is an urgent need to develop antimycobacterials with novel mechanisms of action. Maintenance of redox homeostasis is integral to mycobacterial survival and growth. Therefore, perturbation of this equilibrium can result in irreversible stress induction and inhibition of growth. Herein, we review a number of small molecules that have either been designed to induce redox stress or were found to do so after their discovery...
May 14, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29758263/page4-and-conformational-switching-insights-from-molecular-dynamics-simulations-and-implications-for-prostate-cancer
#13
Xingcheng Lin, Susmita Roy, Mohit Kumar Jolly, Federico Bocci, Nicholas P Schafer, Min-Yeh Tsai, Yihong Chen, Yanan He, Alexander Grishaev, Keith Weninger, John Orban, Prakash Kulkarni, Govindan Rangarajan, Herbert Levine, José N Onuchic
Prostate-Associated Gene 4 (PAGE4) is an intrinsically disordered protein (IDP) implicated in prostate cancer. The stress-response kinase Homeodomain-Interacting Protein Kinase 1 (HIPK1) phosphorylates two residues in PAGE4, serine 9 and threonine 51. Phosphorylation of these two residues facilitates the interaction of PAGE4 with Activator Protein-1 (AP-1) transcription factor complex to potentiate AP-1's activity. In contrast, hyperphosphorylation of PAGE4 by CDC-Like Kinase 2 (CLK2) attenuates this interaction with AP-1...
May 11, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29758220/evaluation-of-an-aggressive-prostate-biopsy-strategy-in-men-younger-than-50-years-of-age
#14
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Christopher J D Wallis, Ants Toi, Rashid Sayyid, Bimal Bhindi, Michael Nesbitt, Andrew Evans, Theo van der Kwast, Joan Sweet, Nathan Perlis, Robert J Hamilton, Girish S Kulkarni, Antonio Finelli, Alexandre Zlotta, Neil Fleshner
INTRODUCTION: Longitudinal cohort studies and guidelines demonstrate that PSA ≥1 ng/mL in younger patients confer an increased risk of delayed prostate cancer (PC) death. In our institution we have used an aggressive biopsy strategy among younger patients with PSA of>1 ng/ml. Our objective was to determine the proportion of detected cancer and specifically, clinical significant cancer, with this strategy. METHODS: The prostate biopsy (PB) database at Princess Margaret Cancer Centre was queried for patients younger than 50 who underwent a first PB between 2000 and 2016...
May 11, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29754092/influence-of-monsoonal-recharge-on-arsenic-and-dissolved-organic-matter-in-the-holocene-and-pleistocene-aquifers-of-the-bengal-basin
#15
Harshad V Kulkarni, Natalie Mladenov, Saugata Datta, Debashis Chatterjee
Arsenic (As) mobilization in the Bengal Basin aquifers has been studied for several decades due to the complex redox bio-geochemistry, dynamic hydrogeology and complex nature of dissolved organic matter (DOM). Earlier studies have examined the changes in groundwater As in the dry season before monsoon and during the wet season after monsoonal recharge. To investigate the more immediate influence of recharge during the active monsoon period on As mobilization and DOM character, groundwater samples were analyzed in the pre-monsoon and during the active monsoon period...
May 10, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29752287/-rnaset2-knockout-rats-exhibit-hippocampal-neuropathology-and-deficits-in-memory
#16
Kerstin W Sinkevicius, Thomas R Morrison, Praveen Kulkarni, Martha K Caffrey Cagliostro, Sade Iriah, Samantha Malmberg, Julia Sabrick, Jennifer A Honeycutt, Kim L Askew, Malav Trivedi, Craig F Ferris
RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity, and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. The goal of this study was to characterize the first rodent model of RNASET2 deficiency. The brains of 3- and 12-month-old RNaseT2 knockout rats were studied using multiple magnetic resonance imaging modalities and behavioral tests...
May 10, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29751443/dissolved-fulvic-acids-from-a-high-arsenic-aquifer-shuttle-electrons-to-enhance-microbial-iron-reduction
#17
Harshad V Kulkarni, Natalie Mladenov, Diane M McKnight, Yan Zheng, Matthew F Kirk, Diana R Nemergut
It was demonstrated more than two decades ago that microorganisms use humic substances, including fulvic acid (FA), as electron shuttles during iron (Fe) reduction in anaerobic soils and sediments. The relevance of this mechanism for the acceleration of Fe(III) reduction in arsenic-laden groundwater environments is gaining wider attention. Here we provide new evidence that dissolved FAs isolated from sediment-influenced surface water and groundwater in the Bengal Basin were capable of electron shuttling between Geobacter metallireducens and Fe(III)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751026/urethroplasty-after-urethral-urolume-stent-an-international-multicenter-experience
#18
Javier C Angulo, Sanjay Kulkarni, Joshi Pankaj, Dmitriy Nikolavsky, Pedro Suarez, Javier Belinky, Ramón Virasoro, Jessica DeLong, Francisco E Martins, Nicolaas Lumen, Carlos Giudice, Oscar A Suárez, Nicolás Menéndez, Leandro Capiel, Damian López-Alvarado, Erick A Ramirez, Krishnan Venkatesan, Maha M Husainat, Cristina Esquinas, Ignacio Arance, Reynaldo Gómez, Richard Santucci
PURPOSE: To evaluate the outcomes and factors affecting success of urethroplasty in patients with stricture recurrence after Urolume® urethral stent. MATERIAL & METHODS: Retrospective international multicenter study on patients treated with urethral reconstruction after Urolume® stent. Stricture and stent length, time between urethral stent insertion and urethroplasty, age, mode of stent retrieval, type of urethroplasty, complications and baseline and post-urethroplasty voiding parameters were analyzed...
May 8, 2018: Urology
https://www.readbyqxmd.com/read/29745937/tgf-%C3%AE-induces-changes-in-breast-cancer-cell-deformability
#19
Ankur Kulkarni, Aritra Chatterjee, Paturu Kondaiah, Namrata Gundiah
Mechanical properties of cells regulate cell behaviors which lead to phenotypic changes that may aid in the development and progression of disease. In this study, we used atomic force microscopy (AFM) indentation with a spherical probe to characterize the elastic and viscoelastic properties of invasive (MDA-MB-231) and noninvasive (MCF-7) breast cancer cells treated with transforming growth factor-β (TGF-β). We also used confocal fluorescence imaging to investigate the sub-membrane cytoskeletal structure of the cells...
May 10, 2018: Physical Biology
https://www.readbyqxmd.com/read/29743776/mini-occupational-health-services-for-un-organized-labor-markets-in-india
#20
EDITORIAL
Ganesh K Kulkarni
No abstract text is available yet for this article.
January 2018: Indian Journal of Occupational and Environmental Medicine
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