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https://www.readbyqxmd.com/read/27911222/the-histone-methyltransferases-set5-and-set1-have-overlapping-functions-in-gene-silencing-and-telomere-maintenance
#1
Meagan Jezek, Alison Gast, Grace Choi, Rushmie Kulkarni, Jeremiah Quijote, Andrew Graham-Yooll, DoHwan Park, Erin M Green
Genes adjacent to telomeres are subject to transcriptional repression mediated by an integrated set of chromatin modifying and remodeling factors. The telomeres of Saccharomyces cerevisiae have served as a model for dissecting the function of diverse chromatin proteins in gene silencing, and their study has revealed overlapping roles for many chromatin proteins in either promoting or antagonizing gene repression. The H3K4 methyltransferase Set1, which is commonly linked to transcriptional activation, has been implicated in telomere silencing...
December 2, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27908373/management-of-panurethral-stricture
#2
REVIEW
Sanjay Kulkarni, Jyotsna Kulkarni, Sandesh Surana, Pankaj M Joshi
Panurethral stricture, involving the penile and bulbar urethra, is seen across the world .It is a complex disease with a relative paucity of literature on the subject. In India, Lichen Sclerosus is the most common cause of panurethral stricture followed by iatrogenic causes. The article presents the authors' experiences of Panurethral stricture repair using a single stage, One side dissection, dorsal onlay repair with oral mucosa graft.
February 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27899415/role-of-chemokine-receptors-and-intestinal-epithelial-cells-in-the-mucosal-inflammation-and-tolerance
#3
REVIEW
Neeraja Kulkarni, Manisha Pathak, Girdhari Lal
The intestinal epithelial lining is a very dynamic interface, where multiple interactions occur with the external world. The intestinal epithelial barrier is continuously exposed to a huge load of commensal microorganisms, food-borne antigens, as well as invading enteropathogens. Intestinal epithelial cells (IECs) and underlying immune cells are the main players in maintaining the delicate balance between gut tolerance and inflammation. IECs deferentially express the variety of chemokines and chemokine receptors, and these receptor-ligand interactions not only mediate the infiltration and activation of immune cells but also switch on the survival cascades in IECs...
November 29, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27896278/lack-of-association-between-slc30a8-variants-and-type-2-diabetes-in-mexican-american-families
#4
Hemant Kulkarni, Manju Mamtani, Juan Manuel Peralta, Vincent Diego, Thomas D Dyer, Harald Goring, Laura Almasy, Michael C Mahaney, Sarah Williams-Blangero, Ravindranath Duggirala, Joanne E Curran, John Blangero
SLC30A8 encodes zinc transporter 8 which is involved in packaging and release of insulin. Evidence for the association of SLC30A8 variants with type 2 diabetes (T2D) is inconclusive. We interrogated single nucleotide polymorphisms (SNPs) around SLC30A8 for association with T2D in high-risk, pedigreed individuals from extended Mexican American families. This study of 118 SNPs within 50 kb of the SLC30A8 locus tested the association with eight T2D-related traits at four levels: (i) each SNP using measured genotype approach (MGA); (ii) interaction of SNPs with age and sex; (iii) combinations of SNPs using Bayesian Quantitative Trait Nucleotide (BQTN) analyses; and (iv) entire gene locus using the gene burden test...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27895271/examination-of-antibody-responses-as-a-measure-of-exposure-to-malaria-in-the-indigenous-batwa-and-their-non-indigenous-neighbors-in-southwestern-uganda
#5
Manisha A Kulkarni, Gala Garrod, Lea Berrang-Ford, Isaac Ssewanyana, Sherilee L Harper, Nestor Baraheberwa, Blanaid Donnelly, Kaitlin Patterson, Didacus B Namanya, Shuaib Lwasa, Chris Drakeley
Understanding variations in malaria transmission and exposure is critical to identify populations at risk and enable better targeting of interventions. The Indigenous Batwa of southwestern Uganda have a disproportionate burden of malaria infection compared with their non-Indigenous neighbors. To better understand the individual- and community-level determinants of malaria exposure, a seroepidemiological study was conducted in 10 local council cells in Kanungu District, Uganda, in April 2014. The Batwa had twice the odds of being seropositive to two Plasmodium falciparum-specific antigens, apical membrane antigen-1 and merozoite surface protein-119, compared with the non-Indigenous Bakiga (odds ratio = 2...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27891475/self-reported-obstacles-to-regular-dental-care-among-information-technology-professionals
#6
L Swetha Reddy, Dolar Doshi, B Srikanth Reddy, Suhas Kulkarni, M Padma Reddy, D Satyanarayana, Pavan Baldava
INTRODUCTION: Good oral health is important for an individual as well as social well-being. Occupational stress and work exhaustion in Information Technology (IT) professionals may influence the oral health and oral health related quality of life. AIM: To assess and compare self-reported obstacles for regular dental care and dental visits among IT professionals based on age, gender, dental insurance and working days per week. MATERIALS AND METHODS: A cross-sectional study was conducted among 1,017 IT professionals to assess the self-reported obstacles to regular oral health care in Hyderabad city, Telangana, India...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891064/proteomic-based-approach-for-characterizing-4-hydroxy-2-nonenal-induced-oxidation-of-buffalo-bubalus-bubalis-and-goat-capra-hircus-meat-myoglobins
#7
Naveena B Maheswarappa, K Usha Rani, Y Praveen Kumar, Vinayak V Kulkarni, Srikanth Rapole
BACKGROUND: Myoglobin (Mb) is a sarcoplasmic heme protein primarily responsible for meat color and its chemistry is species specific. 4-hydroxy-2-nonenal (HNE) is a cytotoxic lipid derived aldehyde detected in meat and was reported to covalently adduct with nucleophilic histidine residues of Mb and predispose it to greater oxidation. However, no literature is available on characterization of lipid oxidation induced oxidation of Indian water buffalo (Bubalus bubalis) and goat (Capra hircus) myoglobins...
2016: Proteome Science
https://www.readbyqxmd.com/read/27889632/synthesis-biological-evaluation-and-in-silico-molecular-modeling-of-pyrrolyl-benzohydrazide-derivatives-as-enoyl-acp-reductase-inhibitors
#8
Shrinivas D Joshi, Sheshagiri R Dixit, Venkatarao H Kulkarni, Christian Lherbet, Mallikarjuna N Nadagouda, Tejraj M Aminabhavi
In efforts to develop lead anti-TB compounds, a novel series of 19 pyrrolyl benzohydrazides were synthesized and screened to target enoyl-ACP reductase enzyme, which is one of the important enzymes involved in type II fatty acid biosynthetic pathway of M. tuberculosis. Pharmacophores were constructed using GALAHAD to generate alignment of data sets and calculated by Pareto ranking. The pharmacophore features were then filtered by Surflex-dock study using enoyl ACP reductase from M. tuberculosis. Compounds 5b and 5d showed H-bonding interactions with Tyr158, Thr196 and co-factor NAD(+) that fitted well within the binding pocket of InhA...
November 17, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27889529/antiviral-activities-of-selected-antimalarials-against-dengue-virus-type-2-and-zika-virus
#9
Anuradha Balasubramanian, Tadahisa Teramoto, Amol A Kulkarni, Apurba K Bhattacharjee, Radhakrishnan Padmanabhan
In a previous study, twelve antimalarial compounds, amodiaquine (AQ) and derivatives, were shown to have potent anti-dengue viral (DENV) activity by using the stable DENV2 Renilla luciferase reporter replicon expressing BHK-21 cells, infectivity (plaque), and the qRT-PCR assays. In this study, we performed molecular modeling on these compounds to determine their stereo-electronic properties required for optimal antiviral activity. Based on the similarity of calculated stereo-electronic profiles, specifically the electrostatic potential profiles of the compounds, and in silico screening of related compounds from literature, we identified three additional compounds, Quinacrine (QC), Mefloquine (MQ), and GSK369796...
November 23, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27888945/radiology-as-the-point-of-cancer-patient-and-care%C3%A2-team-engagement-applying-the-4r-model-at%C3%A2-a-patient-s-breast-cancer-care-initiation
#10
Christine B Weldon, Sarah M Friedewald, Swati A Kulkarni, Melissa A Simon, Ruth C Carlos, Jonathan B Strauss, Mikele M Bunce, Art Small, Julia R Trosman
Radiologists aspire to improve patient experience and engagement, as part of the Triple Aim of health reform. Patient engagement requires active partnerships among health providers and patients, and rigorous teamwork provides a mechanism for this. Patient and care team engagement are crucial at the time of cancer diagnosis and care initiation but are complicated by the necessity to orchestrate many interdependent consultations and care events in a short time. Radiology often serves as the patient entry point into the cancer care system, especially for breast cancer...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27888261/fluctuating-residual-limb-volume-accommodated-with-an-adjustable-modular-socket-design-a-novel-case-report
#11
Kay Mitton, Jai Kulkarni, Kenneth William Dunn, Anthony Hoang Ung
BACKGROUND: This novel case report describes the problems of prescribing a prosthetic socket in a left transfemoral amputee secondary to chronic patellofemoral instability compounded by complex regional pain syndrome. CASE DESCRIPTION AND METHODS: Following the amputation, complex regional pain syndrome symptoms recurred in the residual limb, presenting mainly with oedema. Due to extreme daily volume fluctuations of the residual limb, a conventional, laminated thermoplastic socket fitting was not feasible...
November 24, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27868445/acetone-and-methanol-fruit-extracts-of-terminalia-paniculata-inhibit-hiv-1-infection-in-vitro
#12
Ankita Durge, Pratiksha Jadaun, Ashish Wadhwani, Ashish A Chinchansure, Madhukar Said, H V Thulasiram, Swati P Joshi, Smita S Kulkarni
In this study, we report the in vitro anti-HIV1 activity of acetone and methanol extracts of fruit of Terminalia paniculata. Cytotoxicity tests were conducted on TZM-bl cells and peripheral blood mononuclear cells (PBMC), the CC50 values of both the extracts were ≥260 μg/mL. Using TZM-bl cells, the extracts were tested for their ability to inhibit replication of two primary isolates HIV-1 (X4, Subtype D) and HIV-1 (R5, Subtype C). The activity against HIV-1 primary isolate (R5, Subtype C) was confirmed using activated PBMC and by quantification of HIV-1 p24 antigen...
November 20, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27868333/to-measure-or-not-to-measure-direct-oral-anticoagulants-before-surgery-or-invasive-procedures-comment
#13
R Selby, Z Shah, L Black, J Ongteco, S Kulkarni, D Piraino
With interest, we read a recent publication by Armando Tripodi, aimed at discussing whether direct oral anticoagulants (DOACs) should be measured prior to surgical or invasive procedures [1]. Although specific assays for the assessment of anticoagulant activity of the direct oral anticoagulants (dabigatran and the oral factor Xa inhibitors) have been developed and are easy to perform on automated coagulation analyzers [1-3], they are currently not available in the majority of Ontario laboratories. Since the APTT is readily available at most of our laboratories, we studied the effect of different dabigatran concentrations on the APTT, using six different APTT reagents and performed on three coagulation analyzer platforms...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27867626/perspectives-and-implications-of-the-new-sepsis-clinical-practice-guidelines
#14
COMMENT
Denise McCormack, Miriam Kulkarni, Steven E Keller
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27866612/carotenoid-stabilized-gold-and-silver-nanoparticles-derived-from-the-actinomycete-gordonia-amicalis-hs-11-as-effective-free-radical-scavengers
#15
Harshada Sowani, Pallavi Mohite, Shailesh Damale, Mohan Kulkarni, Smita Zinjarde
The Actinomycete Gordonia amicalis HS-11 produced orange pigments when cultivated on n-hexadecane as the sole carbon source. When cells of this pigmented bacterium were incubated with 1mM chloroauric acid (HAuCl4) or silver nitrate (AgNO3), pH 9.0, at 25°C, gold and silver nanoparticles, respectively, were obtained in a cell associated manner. It was hypothesized that the pigments present in the cells may be mediating metal reduction reactions. After solvent extraction and High Performance Liquid Chromatography, two major pigments displaying UV-vis spectra characteristic of carotenoids were isolated...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27865703/discovery-of-2-2-chloro-6-fluorophenyl-amino-n-3-fluoro-5-trifluoromethyl-phenyl-1-methyl-7-8-dihydro-1h-1-4-dioxino-2-3-3-4-benzo-1-2-d-imidazole-5-carboxamide-as-potent-selective-and-efficacious-microsomal-prostaglandin-e2-synthase-1-mpges-1-inhibitor
#16
Nagarajan Muthukaman, Sanjay Deshmukh, Neelam Sarode, Shital Tondlekar, Macchindra Tambe, Dnyandeo Pisal, Mahamadhanif Shaikh, Vidya G Kattige, Srinivasa Honnegowda, Vikas Karande, Abhay Kulkarni, Satyawan B Jadhav, Mahamad Yunnus A Mahat, Girish S Gudi, Neelima Khairatkar-Joshi, Laxmikant A Gharat
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[d]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be suitable for further profiling in vivo. Compound 17d {2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide} exhibited excellent mPGES-1 enzyme (IC50: 8nM), cell (A549 IC50: 16...
December 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27865162/irradiation-induced-secretion-of-bmp4-by-marrow-cells-causes-marrow-adipogenesis-post-myelosuppression
#17
Manmohan S Bajaj, Rohan S Kulkarni, Suprita S Ghode, Lalita S Limaye, Vaijayanti P Kale
Pre-transplant myeloablation is associated with marrow adipogenesis, resulting in delayed engraftment of hematopoietic stem cells (HSCs). This is strongly undesirable, especially when the donor HSCs are fewer in numbers or have compromised functionality. The molecular mechanisms behind irradiation-induced marrow adipogenesis have not been extensively investigated. Here we show that bone marrow (BM) cells, especially T-cells and stromal cells, express and secrete copious amounts of BMP4 in response to irradiation, which causes the bone marrow stromal cells to commit to adipocyte lineage, thereby contributing to an increase in bone marrow adipogenesis...
November 9, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27863776/parathyroidectomy-prior-to-kidney-transplant-decreases-graft-failure
#18
Glenda G Callender, Jennifer Malinowski, Mahsa Javid, Yawei Zhang, Huang Huang, Courtney E Quinn, Tobias Carling, Ricarda Tomlin, J Douglas Smith, Sanjay Kulkarni
BACKGROUND: Uncorrected uremic hyperparathyroidism is associated with delayed graft function after kidney transplantation. The current guidelines of the Kidney Disease Improving Global Outcomes recommend maintaining parathyroid hormone ≤9x normal in patients pre-kidney transplantation. This study explores the effect of increased levels of serum parathyroid hormone and preoperative parathyroidectomy on outcomes after kidney transplantation. METHODS: A retrospective review was performed of adult patients who underwent kidney transplantation between January 1, 2005, and December 31, 2014, at a single institution...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27862183/the-antiviral-cytokine-interferon-gamma-restricts-neural-stem-progenitor-cell-proliferation-through-activation-of-stat1-and-modulation-of-retinoblastoma-protein-phosphorylation
#19
Apurva Kulkarni, Taylor J Scully, Lauren A O'Donnell
Neural stem/progenitor cells (NPSCs) express receptors for many inflammatory cytokines, with varying effects on differentiation and proliferation depending on the stage of development and the milieu of inflammatory mediators. In primary neurons and astrocytes, we recently showed that interferon gamma (IFNγ), a potent antiviral cytokine that is required for the control and clearance of many central nervous system (CNS) infections, could differentially affect cell survival and cell cycle progression depending upon the cell type and the profile of activated intracellular signaling molecules...
November 15, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27859731/one-pot-ligation-oxidative-deselenization-at-selenocysteine-and-selenocystine
#20
Richard James Payne, Nicholas Mitchell, Sameer Kulkarni, Siyao Wang, Lara Malins
The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for accessing native peptides with serine in place of Sec at the ligation junction. The efficiency of both variants of the one-pot ligation-oxidative deselenization chemistry is probed through the synthesis of a MUC5AC-derived glycopeptide...
November 16, 2016: Chemistry: a European Journal
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