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https://www.readbyqxmd.com/read/28816399/preliminary-results-on-the-photoluminescence-and-optically-stimulated-luminescence-in-cu-doped-and-ag-doped-znb2-x4-b%C3%A2-%C3%A2-li-na-k-x%C3%A2-%C3%A2-cl-br-compounds
#1
Milind Jog, Rajesh Patil, Yogesh More, Mukund Kulkarni, Sanjiv Moharil
Photoluminescence, and optically stimulated luminescence in ZnB2 X4 (B; Li,Na,K: X; Cl,Br) compounds doped with Cu(+) or Ag(+) were studied. Double humped emission bands attributable to the activators were observed in all the samples. The observed photoluminescence of Cu(+) and Ag(+) could be identified with 3d(9) 4s(1) ↔3d(10) and 4d(9) 5s(1) ↔5d(10) transitions respectively. The longer wavelength band (400-500 nm range) could be attributed to the Cu(+) or Ag(+) ion replacing alkali ion at the octahedral alkali site whereas short wavelength band (340-400 nm range) is attributed to a Cu or Ag ion at tetrahedral zinc site...
August 17, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28816197/cytological-changes-in-normal-oral-mucosa-of-individuals-with-tobacco-habits-a-cytomorphometric-study
#2
Pavan Palakurthy, Pavan G Kulkarni, Rateesh K Nandan, T Madhusudan Rao, D Shyam P Reddy, Keerthi Muddana
INTRODUCTION: Oral cancer is one of the six most common cancers in the world, and globally more than 50% of head and neck cancers occur in Asia, remarkably in India. Overall, 200,000 cases of head and neck cancers occur each year in India, among which 80,000 are oral cancers. Epidemiological and clinical studies suggest a causative role of tobacco use in the evolution of oral potentially malignant and malignant disorders. AIMS AND OBJECTIVES: The aim of the study is to evaluate independently and compare the cytological effects of smoking, tobacco chewing, and smoking in conjunction with tobacco chewing on oral mucosa by cytomorphometric analysis...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28811700/primary-myoglobinuria-differentiate-myoglobinuria-from-hemoglobinuria
#3
Dhiraj J Trivedi, Shrirang P Kulkarni, Rakesh Mudaraddi
Myoglobin is dark red colour heme containing protein, stored in muscle. Change in permeability of myolemma causes myoglobin leak in plasma, which is cleared by kidney swiftly. Differentiating myoglobinuria from hemoglobinuria is important. Clinicians concern over myoglobinuria is to protect the patient from acute renal disease. We present a case of primary myoglobinuria, its clinical symptoms, diagnosis and treatment.
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28809765/cyclin-dependent-kinase-5-modulates-the-p2x2a-receptor-channel-gating-through-phosphorylation-of-c-terminal-threonine-372
#4
Claudio Coddou, Rodrigo Sandoval, Patricio Castro, Pablo Lazcano, Maria José Hevia, Milos Rokic, Bradford Hall, Anita Terse, Christian Gonzalez-Billault, Ashok B Kulkarni, Stanko S Stojilkovic, Elias Utreras
The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), which is absent in the splice variant P2X2bR. We therefore investigated the effects of Cdk5 and its neuronal activator, p35, on P2X2aR function. We found an interaction between P2X2aR and Cdk5/p35 by co-immunofluorescence and co-immunoprecipitation in HEK293 cells...
July 17, 2017: Pain
https://www.readbyqxmd.com/read/28809486/assembling-glycan-charged-dolichol-phosphates-chemoenzymatic-synthesis-of-a-haloferax-volcanii-n-glycosylation-pathway-intermediate
#5
Yifat Elharar, Ananda R Podilapu, Ziqiang Guan, Suvarn S Kulkarni, Jerry Eichler
N-glycosylation, the covalent attachment of glycans to select protein target Asn residues, is a post-translational modification performed by all three domains of life. In the halophilic archaea Haloferax volcanii, where understanding of this universal protein-processing event is relatively well-advanced, genes encoding the components of the Agl (archaeal glycosylation) pathway responsible for the assembly and attachment of an N-linked pentasaccharide have been identified. As elsewhere, the N-linked glycan is assembled on phosphodolichol carriers before transfer to target Asn residues...
August 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28808382/allium-sativum-constituents-exhibit-anti-tubercular-activity-in-vitro-and-in-raw-264-7-mouse-macrophage-cells-infected-with-mycobacterium-tuberculosis-h37rv
#6
Swapna S Nair, Sujay S Gaikwad, Savita P Kulkarni, Alka Pravin Mukne
BACKGROUND: Long duration of treatment, side-effects of currently used anti-tubercular drugs and emergence of drug-resistant forms of Mycobacterium tuberculosis (MTB) warrants the need to develop new drugs to tackle the scourge of tuberculosis (TB). Garlic is an edible plant reported to have anti-tubercular activity. However, previous researches on anti-tubercular effect of garlic were focused mostly on preliminary in vitro screening. OBJECTIVE: To identify constituents responsible for anti-tubercular activity of thiosulfinate-derivative rich extract of garlic (GE) and to evaluate activity of the most active constituent in RAW 264...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807897/cytoplasmic-poly-a-binding-protein-pabpc2-critically-regulates-epidermal-maintenance-and-turnover-in-planarian-schmidtea-mediterranea
#7
Dhiru Bansal, Jahnavi Kulkarni, Kavana Nadahalli, Vairavan Lakshmanan, Srikar Krishna, Vidyanand Sasidharan, Jini Geo, Shilpa Dilipkumar, Renu Pasricha, Akash Gulyani, Srikala Raghavan, Dasaradhi Palakodeti
Identifying key cellular events that facilitate stem cell function and tissue organization is critical for understanding the process of regeneration. Planarians are powerful model system to study regeneration and stem cell (neoblast) function. Here, using planaria, we show that the initial events of regeneration, such as epithelialization and epidermal organization are critically regulated by a novel cytoplasmic Poly A binding protein, SMED-PABPC2. Knockdown (KD) of Smed-pabpc2 leads to defects in epidermal lineage specification, disorganization of epidermis and ECM, and deregulated wound healing resulting in the selective failure of neoblast proliferation near the wound region...
August 14, 2017: Development
https://www.readbyqxmd.com/read/28807449/non-invasive-intra-cardiac-pressure-measurements-using-subharmonic-aided-pressure-estimation-proof-of-concept-in-humans
#8
Jaydev K Dave, Sushmita V Kulkarni, Purva P Pangaonkar, Maria Stanczak, Maureen E McDonald, Ira S Cohen, Praveen Mehrotra, Michael P Savage, Paul Walinsky, Nicholas J Ruggiero, David L Fischman, David Ogilby, Carolyn VanWhy, Matthew Lombardi, Flemming Forsberg
This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28803969/molecular-detection-and-characterization-of-influenza-c-viruses-from-western-india
#9
V A Potdar, D D Hinge, M R Dakhave, A Manchanda, N Jadhav, P B Kulkarni, M S Chadha
Since 2003, India has had a well-established influenza surveillance network, though Influenza C virus was not the focus of study. We therefore retrospectively analyzed clinical samples from Pune, western India collected during January 2009 to August 2015, by real-time RT-PCR. Three of 2530 samples of patients with influenza-like illness (ILI) or severe acute respiratory illness (SARI) showed positivity for Influenza C virus infection, while 105 and 31 samples were positive for Influenza A and B viruses respectively...
August 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28802426/comparison-between-antegrade-intramedullary-nailing-imn-open-reduction-plate-osteosynthesis-orpo-and-minimally-invasive-plate-osteosynthesis-mipo-in-treatment-of-humerus-diaphyseal-fractures
#10
Vidisha Sunil Kulkarni, Madhura Sujay Kulkarni, Govind Shivram Kulkarni, Vaibhav Goyal, Milind Govind Kulkarni
INTRODUCTION: The three currently used methods of treatment: namely open reduction plate osteosynthesis (ORPO), Minimally invasive plate osteosynthesis (MIPO), antegrade intramedullary nailing(IMN) are all reported as satisfactory procedures for treatment of humeral shaft fractures. However none of the published reports have a comparison of superiority of one procedure over the other. We evaluated the clinical, radiological and functional outcome of the three procedures. MATERIALS AND METHODS: We studied adult patients with humerus shaft fractures over a period of 2 years from May 2014 to May 2016 in a level 1 trauma center...
August 2017: Injury
https://www.readbyqxmd.com/read/28802421/symptomatic-medial-humeral-epicondylar-fracture-non-union-rare-presentation-of-a-relatively-common-injury
#11
Vidisha S Kulkarni, Nitish Arora, Harshit Gehlot, Sagar Saxena, Sunil G Kulkarni, Supreet Bajwa
BACKGROUND: Symptomatic non-union of medial humeral epicondylar fractures is a limited entity. Some studies recommend surgical excision of the fragment, but the results are controversial. The purpose of this study is to evaluate the outcome of open reduction and internal fixation of a medial epicondyle non-union fragment. MATERIALS AND METHODS: A retrospective study was conducted in all the patients, who were operated in our hospital between the year 2010 and 2015 for symptomatic medial humeral epicondyle non-union...
August 2017: Injury
https://www.readbyqxmd.com/read/28802416/accuracy-of-valgus-osteotomy-using-dynamic-hip-screw
#12
Sunil G Kulkarni, G S Kulkarni, Sushrut Babhulkar, Milind G Kulkarni, Ruta M Kulkarni
BACKGROUND: Non-union of neck femur is a common but difficult situation to manage especially in young adults. There are two main options of arthroplasty or osteotomy. The aim of this study was to assess the results of intertrochanteric valgus osteotomy in non-union femoral neck fractures. PATIENTS AND METHODS: We present a study of 44 cases of neck femur non-union including untreated fractures, late presentations (more than 3 weeks), treated with compression screw, DHS...
August 2017: Injury
https://www.readbyqxmd.com/read/28802415/augmentation-of-intramedullary-nailing-in-unstable-intertrochanteric-fractures-using-cerclage-wire-and-lag-screws-a-comparative-study
#13
Sunil Govind Kulkarni, Sushrut Sudhir Babhulkar, Sujay Milind Kulkarni, Govind Shivram Kulkarni, Madhura Sujay Kulkarni, Raviraj Patil
BACKGROUND: Unstable intertrochanteric fractures present a challenge to orthopaedic surgeons, with varied geometry of the fractures and a wide choice of implants and techniques. The patients are usually osteoporotic, with multiple co-morbidities and poor tolerance for complications and re-operations. Lateral wall reconstruction and stability of the trochanteric fragments are considered important in providing a better outcome of these difficult injuries. We present a technique of lateral wall and trochanteric reconstruction using Cerclage wires and lag screws in the greater trochanter in addition to intramedullary nailing, and the radiological and functional outcome of this technique of augmentation...
August 2017: Injury
https://www.readbyqxmd.com/read/28801028/convergent-evolution-of-germ-granule-nucleators-a-hypothesis
#14
Arpita Kulkarni, Cassandra G Extavour
Germ cells have been considered "the ultimate stem cell" because they alone, during normal development of sexually reproducing organisms, are able to give rise to all organismal cell types. Morphological descriptions of a specialized cytoplasm termed 'germ plasm' and associated electron dense ribonucleoprotein (RNP) structures called 'germ granules' within germ cells date back as early as the 1800s. Both germ plasm and germ granules are implicated in germ line specification across metazoans. However, at a molecular level, little is currently understood about the molecular mechanisms that assemble these entities in germ cells...
July 19, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28798471/identification-of-competing-endogenous-rnas-of-the-tumor-suppressor-gene-pten-a-probabilistic-approach
#15
Kourosh Zarringhalam, Yvonne Tay, Prajna Kulkarni, Assaf C Bester, Pier Paolo Pandolfi, Rahul V Kulkarni
Regulation by microRNAs (miRNAs) and modulation of miRNA activity are critical components of diverse cellular processes. Recent research has shown that miRNA-based regulation of the tumor suppressor gene PTEN can be modulated by the expression of other miRNA targets acting as competing endogenous RNAs (ceRNAs). However, the key sequence-based features enabling a transcript to act as an effective ceRNA are not well understood and a quantitative model associating statistical significance to such features is currently lacking...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798243/bimaxillary-concomitant-hypohyperdontia-in-a-10-year-old-child
#16
Pratik B Kariya, Sweta Singh, Narayan Kulkarni, Ankita Arora
Numerical anomalies, either addition or deletion, are quite a common findings in human dentition. However, it is extremely rare to find both hypodontia and hyperdontia simultaneously in the same individual. This condition is referred as concomitant hypohyperdontia (CHH). Aetiology of this condition is still obscure. The prevalence of CHH has been reported to be between 0.002% and 3.1%. This case report highlights a rare occurrence of bimaxillary CHH represented by the absence of both mandibular central incisors and presence of two supernumerary teeth in the maxillary anterior segment...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28797293/health-care-providers-perceptions-of-use-and-influence-of-clinical-decision-support-reminders-qualitative-study-following-a-randomized-trial-to-improve-hpv-vaccination-rates
#17
Brian E Dixon, Monica L Kasting, Shannon Wilson, Amit Kulkarni, Gregory D Zimet, Stephen M Downs
BACKGROUND: Human Papillomavirus (HPV) leads to serious health issues and remains the most common sexually transmitted infection. Despite availability of effective vaccines, HPV vaccination rates are suboptimal. Furthermore, providers recommend the HPV vaccine less than half the time for eligible patients. Prior informatics research has demonstrated the effectiveness of computer-based clinical decision support (CDS) in changing provider behavior, especially in the area of preventative services...
August 10, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28794525/utility-of-non-invasive-haemoglobin-monitoring-in-oncosurgery-patients
#18
Namrata Gupta, Anita Kulkarni, A K Bhargava, Aditya Prakash, Nitika Gupta
BACKGROUND AND AIMS: Oncosurgeries may incur massive blood loss demanding frequent blood sampling to assess blood loss and the need for intraoperative blood transfusions. Accuracy of non-invasive spectrophotometric haemoglobin (hereafter to be referred as SpHb) monitoring has been studied in various perioperative settings. The intraoperative use of Radical-7(®), Masimo Corp., (Radical-7(®)) for SpHb monitoring may be useful during cancer surgery. The aim of this study is to evaluate the intraoperative utility of SpHb monitoring by the Radical-7(®) to guide intraoperative transfusion in oncosurgeries...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28790783/hydrogen-peroxide-test-for-intraoperative-bile-leak-detection
#19
V Trehan, Pankaj P Rao, C S Naidu, Anuj K Sharma, A K Singh, Sanjay Sharma, Amit Gaur, S V Kulkarni, N Pathak
BACKGROUND: Bile leakage (BL) is a common complication following liver surgery, ranging from 3 to 27% in different series. To reduce the incidence of post-operative BL various BL tests have been applied since ages, but no method is foolproof and every method has their own limitations. In this study we used a relatively simpler technique to detect the BL intra-operatively. Topical application of 1.5% diluted hydrogen peroxide (H2O2) was used to detect the BL from cut surface of liver and we compared this with conventional saline method to know the efficacy...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28781111/creation-and-internal-validation-of-a-biopsy-avoidance-prediction-tool-to-aid-in-the-choice-of-diagnostic-approach-in-patients-with-prostate-cancer-suspicion
#20
Bimal Bhindi, Haiyan Jiang, Cedric Poyet, Thomas Hermanns, Robert J Hamilton, Kathy Li, Ants Toi, Antonio Finelli, Alexandre R Zlotta, Theodorus H van der Kwast, Andrew Evans, Neil E Fleshner, Girish S Kulkarni
INTRODUCTION: To reduce unnecessary prostate biopsies while using novel tests judiciously, we created a tool to predict the probability of clinically significant prostate cancer (CSPC) vs. low-risk prostate cancer or negative biopsy (i.e., when intervention is likely not needed) among men undergoing initial or repeat biopsy. METHODS: Separate models were created for men undergoing initial and repeat biopsy, identified from our institutional biopsy database and the placebo arm of the REDUCE trial, respectively, to predict the presence of CSPC (Gleason≥7 or>33% of cores involved)...
August 3, 2017: Urologic Oncology
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