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https://www.readbyqxmd.com/read/29149590/just-a-spoonful-of-sugar-htlv-1-style
#1
Naomi Taylor
Host cell metabolism regulates viral infection. In this issue of Cell Chemical Biology, Kulkarni et al. (2017) reveal the importance of oxygen concentrations and glycolysis in the reactivation of human T cell leukemia virus (HTLV-1). Identifying the host metabolic networks that regulate infection will foster our understanding of HTLV-1-associated pathologies.
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29146906/qtl-mapping-and-molecular-characterization-of-the-classical-d-locus-controlling-seed-and-flower-color-in-linum-usitatissimum-flax
#2
Gurudatt Pavagada Sudarshan, Manoj Kulkarni, Leonid Akhov, Paula Ashe, Hamid Shaterian, Sylvie Cloutier, Gordon Rowland, Yangdou Wei, Gopalan Selvaraj
The flowers of flax (linseed) are blue-hued, ephemeral and self-pollinating, and the seeds are typically brown. A century-old interest in natural yellow seed variants and a historical model point to recessive alleles in B1, D and G loci being responsible, but the functional aspects had remained unknown. Here, we characterized the "D" locus by quantitative trait loci (QTL) mapping and identified a FLAVONOID 3'5' HYDROXYLASE (F3'5'H) gene therein. It does not belong to the F3'5'H clade, but resembles biochemically characterized F3'Hs (flavonoid 3' hydroxylase) but without F3'H activity...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145748/application-of-hot-melt-extrusion-for-improving-bioavailability-of-artemisinin-a-thermolabile-drug
#3
C Kulkarni, A L Kelly, T Gough, V Jadhav, K K Singh, A Paradkar
Hot melt extrusion has been used to produce a solid dispersion of the thermolabile drug artemisinin. Formulation and process conditions were optimized prior to evaluation of dissolution and biopharmaceutical performance. Soluplus(®), a low Tg amphiphilic polymer especially designed for solid dispersions enabled melt extrusion at 110 °C although some drug-polymer incompatibility was observed. Addition of 5% citric acid as a pH modifier was found to suppress the degradation. The area under plasma concentration time curve (AUC0-24h) and peak plasma concentration (Cmax) were four times higher for the modified solid dispersion compared to that of pure artemisinin...
November 16, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29140473/jaspar-2018-update-of-the-open-access-database-of-transcription-factor-binding-profiles-and-its-web-framework
#4
Aziz Khan, Oriol Fornes, Arnaud Stigliani, Marius Gheorghe, Jaime A Castro-Mondragon, Robin van der Lee, Adrien Bessy, Jeanne Chèneby, Shubhada R Kulkarni, Ge Tan, Damir Baranasic, David J Arenillas, Albin Sandelin, Klaas Vandepoele, Boris Lenhard, Benoît Ballester, Wyeth W Wasserman, François Parcy, Anthony Mathelier
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. In the 2018 release of JASPAR, the CORE collection has been expanded with 322 new PFMs (60 for vertebrates and 262 for plants) and 33 PFMs were updated (24 for vertebrates, 8 for plants and 1 for insects). These new profiles represent a 30% expansion compared to the 2016 release...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140378/perception-by-osseointegrated-dental-implants-supporting-a-fixed-prosthesis-a-prospective-study
#5
Purva V Bakshi, Srinath Thakur, Sudhindra Kulkarni
PURPOSE: Osseointegrated implants have been shown to transmit a certain sensibility termed as osseoperception. The purpose of this study was to determine the perception by implants over a period of 6 months after loading in comparison to the natural dentition. MATERIALS AND METHODS: Twenty subjects (ages 40 to 50 years) were included in this split-mouth clinical trial. The subjects were divided into two groups (n = 10) as follows: group 1-subjects with recently cemented implant-supported fixed prosthesis opposing natural teeth; group 2-subjects with recently cemented implant-supported fixed prosthesis in both arches...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29138280/foxp1-regulation-of-neonatal-vocalizations-via-cortical-development
#6
Noriyoshi Usui, Daniel J Araujo, Ashwinikumar Kulkarni, Marissa Co, Jacob Ellegood, Matthew Harper, Kazuya Toriumi, Jason P Lerch, Genevieve Konopka
The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 in both brain development and ASD pathophysiology. However, the specific molecular pathways both upstream of and downstream from FOXP1 are not fully understood. To elucidate the contribution of FOXP1-mediated signaling to brain development and, in particular, neocortical development, we generated forebrain-specific Foxp1 conditional knockout mice...
November 14, 2017: Genes & Development
https://www.readbyqxmd.com/read/29133581/global-aphasia-in-a-case-of-bilateral-frontal-lobe-infarcts-involving-both-caudate-nuclei
#7
Davala Krishna Karthik, Vikram Khardenavis, Sharvari Kulkarni, Anirudda Deshpande
No abstract text is available yet for this article.
November 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29133152/laparoscopic-assisted-uterus-retrieval-from-live-organ-donors-for-uterine-transplant
#8
Shailesh Puntambekar, Milind Telang, Pankaj Kulkarni, Sanjeev Jadhav, Ravindra Sathe, Neeta Warty, Seema Puntambekar, Sandesh Kade, Mangesh Panse, Nikhil Agarkhedkar, Giriraj Gandhi, Manoj Manchekar, Hirav Parekh, Kajal Parikh, Riddhi Desai, Mehul Mehta, Mihir Chitale, Sambit Nanda
OBJECTIVE: The authors present the first ever laparoscopic assisted uterus retrieval in live donor for uterus transplant. DESIGN: A step-by-step surgical demonstration SETTING: Galaxy CARE Laparoscopy Institute, Pune, India PATIENT(S): Two patients, ages 21 and 26 with Mayer Rokitansky Kuster Hauser (MRKH) syndrome and Ashermann's syndrome respectively, with their mothers as donors. INTERVENTION(S): A Twelve member team was formed. After review of available literature on uterine transplant a protocol was formulated and submitted to the IRB...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29132684/interactions-between-lactobacilli-and-chicken-macrophages-induce-antiviral-responses-against-avian-influenza-virus
#9
Bahram Shojadoost, Raveendra R Kulkarni, Jennifer T Brisbin, Wanderley Quinteiro-Filho, Tamiru N Alkie, Shayan Sharif
Macrophages are an important cell type of the innate immune system that upon activation, can exert antiviral functions and also can induce virus-specific adaptive immune responses. Macrophage interaction with certain probiotic bacteria such as lactobacilli can enhance antiviral functions of these cells. We have previously shown that administration of lactobacilli to chickens can effectively augment immune response to vaccine antigens. Here, we investigated the effects of representative strains of three Lactobacillus species, L...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29129565/human-papillomavirus-hpv-oncoprotein-e6-facilitates-calcineurin-nuclear-factor-for-activated-t-cells-2-nfat2-signaling-to-promote-cellular-proliferation-in-cervical-cell-carcinoma
#10
Babul Moni Ram, Jayashree Dolpady, Rakesh Kulkarni, R Usha, Usha Bhoria, Usha Rani Poli, Mojahidul Islam, Nirupma Trehanpati, Gayatri Ramakrishna
The calcineurin-NFAT signalling pathway regulates cell proliferation, differentiation, and development in diverse cell types and organ systems. Deregulation of calcineurin-NFAT signalling has been reported in leukaemias and few solid tumors such as breast and colon. In the present study, we found elevated calcineurin protein levels and phosphatase activity in cervical cancer cell lines and depletion of the same attenuated cell proliferation. Additionally, nuclear levels of NFAT2, a downstream target of calcineurin, viz, was found elevated in human papillomavirus (HPV) infected cells, HeLa and SiHa, compared to the HPV negative cells, HaCaT and C33A, indicative of its higher DNA binding activity...
November 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29128993/pancreatic-adenocarcinoma-cross-sectional-imaging-techniques
#11
Naveen M Kulkarni, David M Hough, Parag P Tolat, Erik V Soloff, Avinash R Kambadakone
Pancreatic adenocarcinoma is a common malignancy that has a poor prognosis. Imaging is vital in its detection, staging, and management. Although a variety of imaging techniques are available, MDCT is the preferred imaging modality for staging and assessing the resectability of pancreatic adenocarcinoma. MR also has an important adjunct role, and may be used in addition to CT or as a problem-solving tool. A dedicated pancreatic protocol should be acquired as a biphasic technique optimized for the detection of pancreatic adenocarcinoma and to allow accurate local and distant disease staging...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29128808/attenuation-of-renal-damage-in-type-i-diabetic-rats-by-umbelliferone-a-coumarin-derivative
#12
Mayuresh S Garud, Yogesh A Kulkarni
BACKGROUND: It is well known that diabetes is one of the non-communicable disease affecting a large population worldwide. When diabetes remains untreated or uncontrolled, it leads to further serious complications, affecting vital organs like eyes, kidney, heart, etc. The present study was designed to evaluate effects of umbelliferone, a phytochemical, in treatment of diabetic nephropathy. METHODS: Experimental model used was streptozotocin (55mg/kg, ip) induced diabetic nephropathy in male Sprague Dawley rats...
June 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128646/hiv-drug-resistance-following-a-decade-of-free-antiretroviral-therapy-program-in-india-a-review
#13
REVIEW
Santosh Karade, Devidas N Chaturbhuj, Sourav Sen, Rajneesh K Joshi, Smita S Kulkarni, Subramanian Shankar, Raman R Gangakhedkar
OBJECTIVE: The objective of this review is to assess the burden of HIV drug resistance mutations (DRM) in Indian adults exposed to first-line ART as per national guidelines. METHODS: We performed advanced search for the published literature on HIV drug resistance in India in PubMed and Scopus. From each publication data pertaining to age, sex, CD4 count and viral load, prevalence of NRTI/NNRTI drug resistance mutations (DRM) was extracted. Year-wise Indian HIV-1 reverse transcriptase (RT) sequences were retrieved from Los Alamos HIV database and mutation analyses were performed...
November 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29126851/ccr6-signaling-inhibits-suppressor-function-of-induced-treg-during-gut-inflammation
#14
Neeraja Kulkarni, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Praveen Kumar Sharma, Vikkarasan Rehman Mujeeb, Sharad Srivastava, Ramanamurthy Boppana, Girdhari Lal
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling were not known. Here, we show that during gut inflammation, the frequency of Foxp3(+)CD4(+) T cells (Tregs) reduced in the secondary lymphoid tissues and CCR6(+) Tregs enhanced the expression of RORγt. The peripheral blood mononuclear cells (PBMCs) of ulcerative colitis (UC) patients showed lower percentages of Foxp3(+)CD4(+) T cells, as compared to healthy individuals, with CCR6(+) Tregs showing higher RORγt expression as compared to CCR6(-)Tregs...
November 7, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29118512/multiple-white-dots-on-posterior-capsule
#15
Chidanand Kulkarni
A 38 years old female patient presented with unilateral cataract without known predisposing factors. During cataract extraction, the surgeon noticed multiple white dots scattered over inner surface of the posterior capsule. These dots were of uniform size and shape. They were distributed uniformly and involved all the areas of the posterior capsule and extended up to equator. The surgeon decided to implant IOL and tackle the opacities in a later setup. In spite of the extensive opacities, the patient's Uncorrected Corrected Visual Acuity (UCVA) at six weeks was 6/9, Best Corrected Visual Acuity(BCVA) was 6/6 and near vision with correction was N6...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118365/impaired-development-of-the-cerebral-cortex-in-infants-with-congenital-heart-disease-is-correlated-to-reduced-cerebral-oxygen-delivery
#16
Christopher J Kelly, Antonios Makropoulos, Lucilio Cordero-Grande, Jana Hutter, Anthony Price, Emer Hughes, Maria Murgasova, Rui Pedro A G Teixeira, Johannes K Steinweg, Sagar Kulkarni, Loay Rahman, Hui Zhang, Daniel C Alexander, Kuberan Pushparajah, Daniel Rueckert, Joseph V Hajnal, John Simpson, A David Edwards, Mary A Rutherford, Serena J Counsell
Neurodevelopmental impairment is the most common comorbidity associated with complex congenital heart disease (CHD), while the underlying biological mechanism remains unclear. We hypothesised that impaired cerebral oxygen delivery in infants with CHD is a cause of impaired cortical development, and predicted that cardiac lesions most associated with reduced cerebral oxygen delivery would demonstrate the greatest impairment of cortical development. We compared 30 newborns with complex CHD prior to surgery and 30 age-matched healthy controls using brain MRI...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118280/association-between-social-anxiety-with-oral-hygiene-status-and-tongue-coating-among-patients-with-subjective-halitosis
#17
Jenisha Patel, Suhas Kulkarni, Dolar Doshi, Padma Reddy, Srikanth Reddy, Adepu Srilatha
Purpose: Halitosis is a universal affliction suffered by many individuals irrespective of age, sex and social status. Concern about oral malodor can significantly impede an individual's personal, professional and public life which can lead to the development of social anxiety. The present study was undertaken to assess the association between social anxiety with oral hygiene status and tongue coating among patients with subjective halitosis.Methods: A total of 321(n=321) subjects were self-recruited to participate in this IRB approved study...
October 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29117777/-testing-testing-multiple-hiv-positive-tests-among-patients-initiating-antiretroviral-therapy-in-ethiopia
#18
Sarah Kulkarni, Olga Tymejczyk, Tsigereda Gadisa, Maria Lahuerta, Robert H Remien, Zenebe Melaku, Wafaa El-Sadr, Batya Elul, Denis Nash, Susie Hoffman
Repeat HIV testing after receiving a positive result has never been studied systematically and may give insight into reasons for delayed linkage to care. Among 831 adults in 6 secondary facilities in Oromia, Ethiopia, who completed an interviewer-administered structured questionnaire within 2 weeks of initiating antiretroviral therapy in 2012 to 2013, 110 (13.2%) reported having retested after an HIV-positive result. The odds of repeat (versus single) HIV-positive testing were higher among those who had doubted their HIV status (adjusted odds ratio [AOR]ref=nodoubt = 6...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29117637/secondary-ion-mass-spectrometry-imaging-and-multivariate-data-analysis-reveal-co-aggregation-patterns-of-populus-trichocarpa-leaf-surface-compounds-on-a-micrometer-scale
#19
Purva Kulkarni, Mina Dost, Özgül Demir Bulut, Alexander Welle, Sebastian Böcker, Wilhelm Boland, Aleš Svatoš
Spatially resolved analysis of a multitude of compound classes has become feasible with the rapid advancement in mass spectrometry imaging strategies. In this study, we present a protocol that combines high lateral resolution TOF-SIMS imaging with a multivariate data analysis (MVA) approach to probe the complex leaf surface chemistry of Populus trichocarpa. Here, epicuticular waxes (EWs) found on the adaxial leaf surface of Populus trichocarpa were blotted on silicon wafers and imaged using time-of-flight secondary ion mass spectrometry (TOF-SIMS) at 10 μm and 1 μm lateral resolution...
November 8, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29113840/extended-venous-thromboembolism-prophylaxis-after-radical-cystectomy-a-call-for-adherence-to-current-guidelines
#20
REVIEW
Zachary Klaassen, Karan Arora, Hanan Goldberg, Thenappan Chandrasekar, Christopher J D Wallis, Rashid K Sayyid, Neil E Fleshner, Antonio Finelli, Alexander Kutikov, Philippe D Violette, Girish S Kulkarni
PURPOSE: Radical cystectomy (RC) is an inherently morbid procedure. The purpose of this review is to assess the timing and incidence of venous thromboembolism (VTE), review current guideline recommendations, and provide evidence for considering extended VTE prophylaxis among all patients undergoing RC. MATERIALS AND METHODS: We conducted a PubMed search of available literature for RC and VTE, focusing on: incidence and timing, evidence supporting extended VTE prophylaxis (among RC and abdominal surgical oncology patients), current guideline recommendations, safety considerations, and direct oral anticoagulants...
November 4, 2017: Journal of Urology
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