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JOURNAL ARTICLE
Santosh Wadile, Divya Kondgekar, Ashishkumar Moreshwar Banpurkar, Shahena Parveen Raeen, Komal Kulkarni, Snehal Kulkarni
Closure of the large ventricular septal defects (VSD) in infancy can lead to normalization of growth, but data are limited. Our study is done to assess the growth pattern in different age groups of children and lower birth weight babies after shunt closure. This is a prospective observational study that included infants with isolated large VSD operated in infancy. Anthropometric data were collected at baseline and at follow-up, and growth patterns were analyzed. 99 infants were included in the study. The mean age and weight at the time of surgery were 6...
April 18, 2024: Pediatric Cardiology
#2
JOURNAL ARTICLE
Marco Biroli, Manas Kulkarni, Satya N Majumdar, Grégory Schehr
We study a one dimensional gas of N noninteracting diffusing particles in a harmonic trap, whose stiffness switches between two values μ_{1} and μ_{2} with constant rates r_{1} and r_{2}, respectively. Despite the absence of direct interaction between the particles, we show that strong correlations between them emerge in the stationary state at long times, induced purely by the dynamics itself. We compute exactly the joint distribution of the positions of the particles in the stationary state, which allows us to compute several physical observables analytically...
March 2024: Physical Review. E
#3
REVIEW
Namdev Dhas, Ritu Kudarha, Ruchi Tiwari, Gaurav Tiwari, Neha Garg, Praveen Kumar, Sanjay Kulkarni, Jahnavi Kulkarni, Soji Soman, Aswathi R Hegde, Jayvadan Patel, Atul Garkal, Anam Sami, Deepanjan Datta, Viola Colaco, Tejal Mehta, Lalitkumar Vora, Srinivas Mutalik
Ferroptosis is a novel type of controlled cell death resulting from an imbalance between oxidative harm and protective mechanisms, demonstrating significant potential in combating cancer. It differs from other forms of cell death, such as apoptosis and necrosis. Molecular therapeutics have hard time playing the long-acting role of ferroptosis induction due to their limited water solubility, low cell targeting capacity, and quick metabolism in vivo. To this end, small molecule inducers based on biological factors have long been used as strategy to induce cell death...
April 15, 2024: Life Sciences
#4
JOURNAL ARTICLE
Zihang Wei, Yang Zhou, Zihao Li, Mihir Kulkarni, Yunlong Zhang
The existing methodologies for allocating highway safety improvement funding closely rely on the utilization of crash prediction models. Specifically, these models produce predictions that estimate future crash hazard levels in different geographical areas, which subsequently support the future funding allocation strategies. In recent years, there is a burgeoning interest in applying artificial intelligence (AI)-based models to perform crash prediction tasks. Despite the remarkable accuracy of these AI-based crash prediction models, they have been observed to yield biased prediction outcomes across areas of different socioeconomic statuses...
April 16, 2024: Accident; Analysis and Prevention
#5
JOURNAL ARTICLE
Aditya Kulkarni, Jianli Zhou, Neha Biyani, Umesh Kathad, Partha P Banerjee, Shiv Srivastava, Zsombor Prucsi, Kamil Solarczyk, Kishor Bhatia, Reginald B Ewesuedo, Panna Sharma
Homologous recombination (HR) related gene alterations are present in a significant subset of prostate, breast, ovarian, pancreatic, lung and colon cancers rendering these tumors as potential responders to specific DNA damaging agents. A small molecule acylfulvene prodrug, LP-184, metabolizes to an active compound by the oxidoreductase activity of enzyme Prostaglandin Reductase 1 (PTGR1), which is frequently elevated in multiple solid tumor types. Prior work demonstrated that cancer cell lines deficient in a spectrum of (DNA damage repair) DDR pathway genes show increased susceptibility to LP-184...
April 17, 2024: Cancer Res Commun
#6
JOURNAL ARTICLE
Aniket D Kulkarni, Naomi Tepper, Chirag G Patel, Michael Monsour, Heather D Tevendale, Anna W Brittain, Maura Whiteman, Emilia H Koumans
Objective: To examine claims for reversible prescription contraceptives and chlamydia and gonorrhea testing among commercially and Medicaid-insured adolescent and young adult (AYA) females in the United States. Methods: Using IBM MarketScan Research Databases, we identified sexually active, nonpregnant AYA (15- to 24-year-old) females enrolled in 2018. We examined claims for reversible prescription contraceptives and chlamydia and gonorrhea testing, using drug names and diagnosis/procedure codes, by age-group in commercially and Medicaid-insured separately and by race/ethnicity in Medicaid-insured...
April 17, 2024: Journal of Women's Health
#7
JOURNAL ARTICLE
Sarah L Khan, Sonye K Danoff, Tejaswini Kulkarni, Janell Reichuber, Adrian Shifren, Oksana A Shlobin, Krishna Thavarajah, Krishnan Warrior, Amy Hajari Case
No abstract text is available yet for this article.
April 16, 2024: Annals of the American Thoracic Society
#8
JOURNAL ARTICLE
Dilip B Magdum, Noopur A Kulkarni, Pratibha G Kavle, Swati Paraye, Pritam S Pohankar, Amol V Giram
INTRODUCTION: Inflammation is a definitive characteristic of carcinogenesis. The neutrophil-to-lymphocyte ratio (NLR) is an easy and efficient indicator of inflammation and a valuable marker in individuals with malignancies. The present study was performed to ascertain NLR values in salivary samples collected from individuals with oral premalignant disorders (OPMDs) and to assess the prognostic significance of NLR in distinguishing OPMDs from oral malignancies. MATERIALS AND METHODS: This study was conducted on 50 patients histopathologically diagnosed with OPMDs with mild dysplasia...
March 2024: Curēus
#9
JOURNAL ARTICLE
Palak Sharma, T R Dilip, Anjali Kulkarni, Udaya Shankar Mishra, Yogesh Shejul
BACKGROUND: Diabetes prevalence has increased over the past few decades, and the shift of the burden of diabetes from the older population to the younger population has increased the exposure of longer durations in a morbid state. The study aimed at ascertaining the likelihood of progression to diabetes and to estimate the onset of diabetes within the urban community of Mumbai. METHODS: This study utilized an observational retrospective non-diabetic cohort comprising 1629 individuals enrolled in a health security scheme...
April 15, 2024: BMC Public Health
#10
Sumeet Kulkarni
No abstract text is available yet for this article.
April 15, 2024: Nature
#11
JOURNAL ARTICLE
Pooja Gala, Arunima Ticku, Tanvi Pawar, Shivani Sapre, Pooja Gupta, Kaavya Iyer, Hansika Kapoor, Rupa Kalahasthi, Savita Kulkarni, Poorvi Iyer
OBJECTIVES: A significant gap is observed between the proportion of individuals suffering from mental health (MH)-related conditions and those receiving adequate MH care services, especially in rural areas. This study highlights and contextualizes MH concerns and its extant knowledge as well as gender roles in rural Maharashtra (India). METHODS: Using in-depth interviews, MH themes were highlighted analytically among 72 female beneficiaries of Svatantra from the six administrative divisions (Konkan, Nashik, Pune, Aurangabad, Amravati and Nagpur) in the state of Maharashtra, India...
2024: Global Mental Health
#12
JOURNAL ARTICLE
Kala Gnanasekaran Kiruthiga, Anusha Kulkarni, Aparna Joshi, Avinash Pradhan, Sadanand Naik
Mucormycosis usually occurs in immunocompromised patients or those with uncontrolled diabetes. Along the third wave of SARS-CoV-2, an associated angioinvasive opportunistic infection with Mucor, a life-threatening fungal infection, was rampant and emerging. With an increase in the usage of steroids in the COVID scenario, the rate of mucormycosis did take a rapid and alarming increase in King Edward Memorial Hospital, Pune, India. Any delay in the diagnosis and management of the disease was life-threatening...
March 2024: Curēus
#13
Kaushal Kulkarni, Anjan Kumar Dhua, Prabudh Goel, Vishesh Jain, Devendra Kumar Yadav, Sandeep Agarwala, Devasenathipathy Kandasamy
Zinner syndrome, a rare congenital anomaly affecting males, is characterized by atresia of the ejaculatory duct, seminal vesicle cysts, and ipsilateral renal agenesis. This case report details a 2-year-old boy successfully treated with laparoscopic excision of a dilated vas deferens and seminal vesicle cyst. The rarity of Zinner syndrome in pediatric patients underscores the importance of understanding its diagnosis and minimally invasive surgical management.
2024: Journal of Indian Association of Pediatric Surgeons
#14
REVIEW
Smita Pawar, Prashant Pingale, Atul Garkal, Riyaz Ali M Osmani, Kavita Gajbhiye, Madhur Kulkarni, Krutika Pardeshi, Tejal Mehta, Amarjitsing Rajput
Messenger RNA (mRNA) has gained marvelous attention for managing and preventing various conditions like cancer, Alzheimer's, infectious diseases, etc. Due to the quick development and success of the COVID-19 mRNA-based vaccines, mRNA has recently grown in prominence. A lot of products are in clinical trials and some are already FDA-approved. However, still improvements in line of optimizing stability and delivery, reducing immunogenicity, increasing efficiency, expanding therapeutic applications, scalability and manufacturing, and long-term safety monitoring are needed...
April 12, 2024: International Journal of Biological Macromolecules
#15
REVIEW
Rachna Meel, Suyash Kulkarni, Lata Singh, Girish Chinnaswamy, Venkatraman Radhakrishnan, Renu Madan, Archana Sasi, Tanvir Kaur, R S Dhaliwal, Sameer Bakhshi
Retinoblastoma (RB) is the most common childhood intraocular malignancy. Delayed presentation due to a lack of awareness and advanced intraocular tumors are a common scenario in low-middle income countries (LMICs). Remarkable treatment advances have been made in the past few decades allowing globe salvage in advanced intraocular RB (IORB) including systemic chemotherapy with focal consolidation and targeted treatments like intraarterial chemotherapy and intravitreal chemotherapy. However, a lack of availability and affordability limits the use of such advances in LMICs...
April 13, 2024: Indian Journal of Pediatrics
#16
JOURNAL ARTICLE
Kei Nomaguchi, Melissa A Milkie, Veena S Kulkarni, Amira Allen
Despite substantial evidence that racial/ethnic minority communities exhibit distinct mothering practices, research on racial/ethnic differences in how mothers spend time with their children is scant. Using the 2003-2019 American Time Use Survey (N = 44,372), this study documents variations in the amounts of childcare and copresent time spent in various activities with residential children aged 0-17 across White, Black, Latina, and Asian mothers. The results show that racial/ethnic differences in maternal time spent with children are partly due to socioeconomic differences but still exist when these factors are held constant, indicating patterns that reflect each minority community's mothering norms...
March 2024: Social Science Research
#17
JOURNAL ARTICLE
Neha Saini, Deepak Yadav, Mandar Shirolkar, Sivasubramanian Murugappan, Nanasaheb Thorat, Atul Kulkarni
Increased glycine concentrations are associated with altered metabolism of cancer cells and is reflected in the bodily fluids of the brain cancer patients. Various studies have been conducted in past to detect glycine as an imaging biomarker via NMR Spectroscopy tools. However, the use is limited because of the low concentration and different in vivo detection due to overlapping of peaks with myo-inositol in same spectral position. Alongside, little is known about the electrochemical potential of Glycine as a biomarker for brain cancer...
April 10, 2024: Colloids and Surfaces. B, Biointerfaces
#18
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#19
Dhruva Angachekar, Sreedhar Archik, Abhay Narvekar, Abhishek Kulkarni, Shivam Patel
Anterior cruciate ligament (ACL) injuries are a common clinical entity among people involved in contact sports activities. With the number of primary ACL reconstructions increasing, there has been a proportional increase in the revision of failed ACL reconstruction surgeries. As our understanding of knee kinematics improves over time, there has been evidence that alignment of the lower limb weight-bearing axis also plays an important part in ACL functioning. Medial opening wedge high tibial osteotomy (MOWHTO) is one such procedure that has been used extensively worldwide to correct the varus lower limb alignment...
March 2024: Curēus
#20
JOURNAL ARTICLE
Christina Ricci, Divya Subburaj, Kate Lim, Neetu Shukla, Jaskiran Kaur, Lin Xie, Meghan Laverty, Dianne Zakaria, Jason Pole, Marie-Claude Pelland-Marcotte, Randy Barber, Sara J Israels, Thai-Hoa Tran, Sapna Oberoi, Samuele Renzi, Tamara MacDonald, Lillian Sung, Ketan Kulkarni
INTRODUCTION: From the advancement of treatment of pediatric cancer diagnosis, the five-year survival rate has increased significantly. However, the adverse consequence of improved survival rate is the second malignant neoplasm. Although previous studies provided information on the incidence and risk of SMN in long term survivors of childhood cancer, there is still scarce information known for short term (< 5 years) prognosis. This study aims to assess the incidence, characteristics, management, and outcome of children who develop SMN malignancies within 5 years of diagnosis of their initial cancer...
2024: Frontiers in Oncology
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