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https://www.readbyqxmd.com/read/29764364/efficient-algorithms-for-polyploid-haplotype-phasing
#1
Dan He, Subrata Saha, Richard Finkers, Laxmi Parida
BACKGROUND: Inference of haplotypes, or the sequence of alleles along the same chromosomes, is a fundamental problem in genetics and is a key component for many analyses including admixture mapping, identifying regions of identity by descent and imputation. Haplotype phasing based on sequencing reads has attracted lots of attentions. Diploid haplotype phasing where the two haplotypes are complimentary have been studied extensively. In this work, we focused on Polyploid haplotype phasing where we aim to phase more than two haplotypes at the same time from sequencing data...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29723468/dart-ms-a-new-analytical-technique-for-forensic-paint-analysis
#2
Mark Maric, James Marano, Robert Bernard Cody, Candice Bridge
Automotive paint evidence is one of the most significant forms of evidence obtained in automotive related incidents. Therefore, the analysis of automotive paint evidence is imperative in forensic casework. Most analytical schemes for automotive paint characterization involve optical microscopy, followed by infrared spectroscopy and pyrolysis-gas chromatography mass spectrometry (py-GCMS) if required. The main drawback with py-GCMS aside from its destructive nature, is that this technique is relatively time intensive in comparison to other techniques...
May 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29675837/batch-bioethanol-production-via-the-biological-and-chemical-saccharification-of-some-egyptian-marine-macroalgae
#3
Ramadan M Soliman, Sherif A Younis, Nour Sh El-Gendy, Soha S M Mostafa, Seham A El-Temtamy, Ahmed I Hashim
AIMS: Marine seaweeds (macroalgae) cause eutrophication problem and affects the touristic activities. The success of the production of the third generation bioethanol from marine macroalgae depends mainly on the development of an ecofriendly and eco-feasible pretreatment (i.e. hydrolysis) technique, a highly effective saccharification step and finally an efficient bioethanol fermentation step. Therefore, this study aimed to investigate the potentiality of different marine macroalgal strains, collected from Egyptian coasts, for bioethanol production via different saccharification processes...
April 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29665724/the-promise-of-complementarity-using-the-methods-of-foresight-for-health-workforce-planning
#4
Gareth H Rees, Peter Crampton, Robin Gauld, Stephen MacDonell
Health workforce planning aims to meet a health system's needs with a sustainable and fit-for-purpose workforce, although its efficacy is reduced in conditions of uncertainty. This PhD breakthrough article offers foresight as a means of addressing this uncertainty and models its complementarity in the context of the health workforce planning problem. The article summarises the findings of a two-case multi-phase mixed method study that incorporates actor analysis, scenario development and policy Delphi. This reveals a few dominant actors of considerable influence who are in conflict over a few critical workforce issues...
January 1, 2018: Health Services Management Research
https://www.readbyqxmd.com/read/29660193/screening-of-semifluorinated-n-alkanes-by-gas-chromatography-coupled-to-dielectric-barrier-discharge-ionization-mass-spectrometry-gc-dbdi-ms
#5
Sebastian Hagenhoff, Ansgar Korf, Ullrich Markgraf, Sebastian Brandt, Alexander Schütz, Joachim Franzke, Heiko Hayen
RATIONALE: The potential of an atmospheric pressure ionization source based on a dielectric barrier discharge in helium for the hyphenation of gas chromatography and mass spectrometry (GC/DBDI-MS) has been demonstrated only recently and for a limited range of compounds. Due to its 'soft' ionization properties and the possibility to choose from a variety of atmospheric pressure ionization MS instruments, GC/DBDI-MS has the potential to be an interesting alternative to 'classic' GC/MS techniques...
April 16, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29655998/four-possible-cases-of-osteomalacia-the-value-of-a-multidisciplinary-diagnostic-approach
#6
A E van der Merwe, B Veselka, H A van Veen, R R van Rijn, K L Colman, H H de Boer
Rickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for diagnosis. The skeletal remains investigated originate from the Meerenberg psychiatric hospital cemetery in Bloemendaal, the Netherlands, and date from 1891 - 1936...
April 11, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#7
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29581064/molecular-signatures-of-medullary-thyroid-carcinoma-by-matrix-assisted-laser-desorption-ionisation-mass-spectrometry-imaging
#8
Andrew Smith, Manuel Galli, Isabella Piga, Vanna Denti, Martina Stella, Clizia Chinello, Nicola Fusco, Davide Leni, Marco Manzoni, Gaia Roversi, Mattia Garancini, Angela Ida Pincelli, Vincenzo Cimino, Giulia Capitoli, Fulvio Magni, Fabio Pagni
The main aim of the study was to assess the feasibility of matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in the pathological investigation of Medullary Thyroid Carcinoma (MTC). Formalin-fixed paraffin-embedded (FFPE) samples from seven MTC patients were analysed by MALDI-MSI in order to detect proteomic alterations within tumour lesions and to define the molecular profiles of specific findings, such as amyloid deposition and C cell hyperplasia (CCH). nLC-ESI MS/MS was employed for the identification of amyloid components and to select alternative proteomic markers of MTC pathogenesis...
March 24, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29562969/equivalence-testing-as-a-tool-for-fatigue-risk-management-in-aviation
#9
Lora J Wu, Philippa H Gander, Margo van den Berg, T Leigh Signal
BACKGROUND: Many civilian aviation regulators favor evidence-based strategies that go beyond hours-of-service approaches for managing fatigue risk. Several countries now allow operations to be flown outside of flight and duty hour limitations, provided airlines demonstrate an alternative method of compliance that yields safety levels "at least equivalent to" the prescriptive regulations. Here we discuss equivalence testing in occupational fatigue risk management. We present suggested ratios/margins of practical equivalence when comparing operations inside and outside of prescriptive regulations for two common aviation safety performance indicators: total in-flight sleep duration and psychomotor vigilance task reaction speed...
April 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29541970/complimentary-care-when-our-patients-request-to-pray
#10
Cheryl Ann Green
Prayer is viewed in modern medicine as a complimentary alternative treatment. However, to many patients, it is a source of hope and comfort. Patients, when facing illness, advanced disease, disability or death, can benefit from prayer. For healthcare providers, comfort with praying with patients can be deemed as unprofessional conduct or blurred therapeutic boundaries, particularly, when prayer is offered to patients' unsolicited by the patient or their family member(s). Therefore, it is imperative that healthcare providers await the request of prayer by the patient before prayer is initiated...
March 14, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29464520/infrared-spectroscopy-and-imaging-in-stem-cells-and-aging-research
#11
Ceren Aksoy, Feride Severcan
The effect of aging process on stem cell function is crucial because of their critical role in tissue regeneration and repair. The impact of aging on stem cells needs to be understood clearly for the success of clinical application and obtaining desired therapeutic outcome throughout the novel stem cell based therapies. The existing methods used to monitor and characterize the stem cells have some unwanted effects on the properties of stem cells and these methods also do not provide real-time information about cellular conditions...
February 21, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29413979/effect-of-tinospora-cordifolia-aqua-alcoholic-extract-on-pharmacokinetic-of-glibenclamide-in-rat-an-herb-drug-interaction-study
#12
Rajanikanta Sahu, Tausif Ahmed, Ramchandra Sangana, Ravindra Punde, Bharat Bhusan Subudhi
Tinospora cordifolia (TC) has been used as a complimentary/alternative medicine against diabetes. Considering its potential to modulate metabolic enzymes, Tinospora cordifolia extract (TCE) may influence the metabolism of the antidiabeic drug Glibenclamide following co-administration. Accordingly, this work was undertaken to evaluate impact of TCE on fate of Glibenclamide. Activity of clinically important Cytochrome P450 isoenzymes were inhibited in the order of CYP2C9 > CYP2D6 > CYP2C19 > CYP1A2 > CYP3A4...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29404572/association-of-rideshare-based-transportation-services-and-missed-primary-care-appointments-a-clinical-trial
#13
Krisda H Chaiyachati, Rebecca A Hubbard, Alyssa Yeager, Brian Mugo, Stephanie Lopez, Elizabeth Asch, Catherine Shi, Judy A Shea, Roy Rosin, David Grande
Importance: Transportation barriers contribute to missed primary care appointments for patients with Medicaid. Rideshare services have been proposed as alternatives to nonemergency medical transportation programs because of convenience and lower costs. Objective: To evaluate the association between rideshare-based medical transportation and missed primary care appointments among Medicaid patients. Design, Setting, and Participants: In a prospective clinical trial, 786 Medicaid beneficiaries who resided in West Philadelphia and were established primary care patients at 1 of 2 academic internal medicine practices located within the same building were included...
March 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29377216/the-safety-and-efficacy-of-low-dose-naltrexone-in-the-management-of-chronic-pain-and-inflammation-in-multiple-sclerosis-fibromyalgia-crohn-s-disease-and-other-chronic-pain-disorders
#14
REVIEW
Denise K Patten, Bob G Schultz, Daniel J Berlau
Chronic inflammatory diseases are complex to treat and have an impact on a large number of patients. Due to the difficulty of treating these diseases and the great impact on quality of life, patients often seek off-label, complimentary, or alternative medicines to gain relief from symptoms. Low-dose naltrexone has been used off-label for treatment of pain and inflammation in multiple sclerosis, Crohn's disease, fibromyalgia, and other diseases. Naltrexone is a mu-opioid receptor antagonist indicated by the U...
March 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29229621/stem-cell-therapy-for-congenital-heart-disease-a-systematic-review
#15
REVIEW
Diamantis I Tsilimigras, Evangelos K Oikonomou, Demetrios Moris, Dimitrios Schizas, Konstantinos P Economopoulos, Konstantinos S Mylonas
BACKGROUND: Congenital heart disease (CHD) constitutes the most prevalent and heterogeneous group of congenital anomalies. Although surgery remains the gold standard treatment modality, stem cell therapy has been gaining ground as a complimentary or alternative treatment option in certain types of CHD. The aim of this study was to present the existing published evidence and ongoing research efforts on the implementation of stem cell-based therapeutic strategies in CHD. METHODS: A systematic review was conducted by searching Medline, ClinicalTrials...
December 12, 2017: Circulation
https://www.readbyqxmd.com/read/29203847/reconceptualization-of-translocator-protein-as-a-biomarker-of-neuroinflammation-in-psychiatry
#16
T Notter, J M Coughlin, A Sawa, U Meyer
A great deal of interest in psychiatric research is currently centered upon the pathogenic role of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands selective for the 18 kDa translocator protein (TSPO) has become the most widely used technique to assess putative neuroimmune abnormalities in vivo. Originally used to detect discrete neurotoxic damages, TSPO has generally turned into a biomarker of 'neuroinflammation' or 'microglial activation'. Psychiatric research has mostly accepted these denotations of TSPO, even if they may be inadequate and misleading under many pathological conditions...
January 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29141791/comparing-the-efficacy-of-disease-modifying-therapies-in-multiple-sclerosis
#17
REVIEW
Dimos D Mitsikostas, Douglas S Goodin
Establishing the relative efficacy and safety of the different disease modifying therapies (DMTs) in multiple sclerosis (MS) is critical to the choice of agent that clinicians recommend for individual MS patients. The best evidence for the relative efficacy of the different DMTs comes from head-to-head randomized clinical trials (RCTs). Understanding that outcome-measures with the best established validity are the relapse rate and the actual (not the "confirmed") change in the extended disability status scale (EDSS), we conclude from these head-to-head RCTs that interferon-beta (IFNβ) given subcutaneously multiple times per week (either IFNβ-1b or IFNβ-1a) and glatiramer acetate (GA) are about equivalent in terms of efficacy and that both of these agents, as well as many of the other DMTs, are superior to weekly intramuscular IFNβ-1a...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28924921/mg-2-induced-dna-compaction-condensation-and-phase-separation-in-gene-delivery-vehicles-based-on-zwitterionic-phospholipids-a-dynamic-light-scattering-and-surface-enhanced-raman-spectroscopic-study
#18
Erhan Süleymanoğlu
Despite the significant efforts towards applying improved non-destructive and label-free measurements of biomolecular structures of lipid-based gene delivery vectors, little is achieved in terms of their structural relevance in gene transfections. Better understanding of structure-activity relationships of lipid-DNA complexes and their gene expression efficiencies thus becomes an essential issue. Raman scattering offers a complimentary measurement technique for following the structural transitions of both DNA and lipid vesicles employed for their transfer...
December 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28842769/time-of-flight-ion-mobility-spectrometry-in-combination-with-laser-induced-fluorescence-detection-system
#19
Florian Uteschil, Andriy Kuklya, Klaus Kerpen, Robert Marks, Ursula Telgheder
A laser-induced fluorescence (LIF) was used as a complimentary detection system for time-of-flight ion mobility spectrometry (TOF-IMS). A LIF detection system is potentially faster than a conventional electrometer detector and can provide additional (to usual for IMS drift time) analytical information, namely wavelength of fluorescence maxima and fluorescence lifetime. Therefore, better discrimination ability can be expected. Additionally, the combination of IMS and LIF operates at atmospheric pressure. This allows fluorescence measurements of specified ions and ion clusters, which would not survive in a mass spectrometer...
November 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28807160/treatment-of-chinese-herbal-medicine-for-female-infertility
#20
Dan Jiang, Lily Li, Bai-Yun Zeng
Female infertility is when a woman of reproductive age and sexual active, without contraception, cannot get pregnant after a year and more or keeps having miscarriages. Although conventional treatments for infertility such as hormone therapy, in vitro fertilization and many more, helped many female patients with infertility get pregnant during past a few decades, it is far from satisfactory with prolonging treatment time frames and emotional and financial burden. In recent years, more patients with infertile problems are seeking to alternative and complementary medicines to achieve a better outcome...
2017: International Review of Neurobiology
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