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https://www.readbyqxmd.com/read/28417096/regulation-of-herbal-medicine-use-based-on-speculation-a-case-from-sri-lanka
#1
Wathsala Wijesinghe, Senaka Pilapitiya, Priyani Hettiarchchi, Buddhika Wijerathne, Sisira Siribaddana
Chronic Kidney Disease of Unknown aetiology is a significant public health problem in Sri Lanka. The final report by the WHO mission recommended regulation of herbal medicines containing aristolochic acid, which is an established nephrotoxin. The use of Complimentary and Alternative Medicine (CAM) has a history of more than 2500 years in Sri Lanka. Aristolochia species are rarely used in Ayurveda and traditional medicine in Sri Lanka. Before regulating the analysis of herbal preparations using Aristolochia, collecting data from CAM practitioners regarding the use of Aristolochia is necessary...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28406932/a-comparison-of-stimulus-types-in-online-classification-of-the-p300-speller-using-language-models
#2
COMPARATIVE STUDY
William Speier, Aniket Deshpande, Lucy Cui, Nand Chandravadia, Dustin Roberts, Nader Pouratian
The P300 Speller is a common brain-computer interface communication system. There are many parallel lines of research underway to overcome the system's low signal to noise ratio and thereby improve performance, including using famous face stimuli and integrating language information into the classifier. While both have been shown separately to provide significant improvements, the two methods have not yet been implemented together to demonstrate that the improvements are complimentary. The goal of this study is therefore twofold...
2017: PloS One
https://www.readbyqxmd.com/read/28276817/bariatric-embolization-a-new-and-effective-option-for-the-obese-patient
#3
Clifford R Weiss, Anjaneya S Kathait
Obesity is a public health epidemic in the United States, which results in significant morbidity, mortality, and cost to the healthcare system. Despite advancements in traditional therapeutic options for the obese patients, there is a treatment gap for patients in whom lifestyle modifications alone have not been successful, but for whom bariatric surgery is not a suitable option. Areas covered: This treatment gap needs to be addressed and thus, complimentary or alternative treatments to lifestyle changes and surgery are urgently needed...
April 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28110528/bisphenol-a-metabolites-and-bisphenol-s-in-paired-maternal-and-cord-serum
#4
Jiaying Liu, Jingguang Li, Yongning Wu, Yunfeng Zhao, Fengji Luo, Shuming Li, Lin Yang, Elham K Moez, Irina Dinu, Jonathan W Martin
Human studies show associations between maternal bisphenol A (BPA) exposure and developmental effects in children, yet biomonitoring of BPA metabolites in maternal and fetal serum remains limited, and less is known for BPA alternatives. BPA-glucuronide, BPA-sulfate, and bisphenol S (BPS) were quantified in 61 pairs of maternal and cord sera from Chinese participants. Total BPS was only detectable in four maternal (<0.03-0.07 ng/mL) and seven cord sera (<0.03-0.12 ng/mL), indicating low exposure but providing the first evidence that BPS crosses the human placenta...
February 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28105555/malaria-and-economic-evaluation-methods-challenges-and-opportunities
#5
Tom L Drake, Yoel Lubell
There is a growing evidence base on the cost effectiveness of malaria interventions. However, certain characteristics of malaria decision problems present a challenge to the application of healthcare economic evaluation methods. This paper identifies five such challenges. The complexities of (i) declining incidence and cost effectiveness in the context of an elimination campaign; (ii) international aid and its effect on resource constraints; and (iii) supranational priority setting, all affect how health economists might use a cost-effectiveness threshold...
January 19, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27698624/integrative-therapies-in-anxiety-treatment-with-special-emphasis-on-the-gut-microbiome
#6
Stephanie L Schnorr, Harriet A Bachner
Over the past decade, research has shown that diet and gut health affects symptoms expressed in stress related disorders, depression, and anxiety through changes in the gut microbiota. Psycho-behavioral function and somatic health interaction have often been ignored in health care with resulting deficits in treatment quality and outcomes. While mental health care requires the professional training in counseling, psychotherapy and psychiatry, complimentary therapeutic strategies, such as attention to a nutritional and diverse diet and supplementation of probiotic foods, may be integrated alongside psychotherapy treatment models...
September 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27697237/determination-of-death-metaphysical-and-biomedical-discourse
#7
REVIEW
Irayda Jakušovaitė, Žydrunė Luneckaitė, Eimantas Peičius, Živilė Bagdonaitė, Olga Riklikienė, Edgaras Stankevičius
The prominence of biomedical criteria relying on brain death reduces the impact of metaphysical, anthropological, psychosocial, cultural, religious, and legal aspects disclosing the real value and essence of human life. The aim of this literature review is to discuss metaphysical and biomedical approaches toward death and their complimentary relationship in the determination of death. A critical appraisal of theoretical and scientific evidence and legal documents supported analytical discourse. In the metaphysical discourse of death, two main questions about what human death is and how to determine the fact of death clearly separate the ontological and epistemological aspects of death...
2016: Medicina
https://www.readbyqxmd.com/read/27598416/factors-influencing-removable-partial-denture-patient-reported-outcomes-of-quality-of-life-and-satisfaction-a-systematic-review
#8
REVIEW
Ingeborg J De Kok, Lyndon F Cooper, Albert D Guckes, Kathleen McGraw, Robert F Wright, Carlos J Barrero, Sun-Yung Bak, Lisa O Stoner
PURPOSE: A systematic search of the literature was performed to identify and characterize articles reporting the influence of removable partial denture (RPD) therapy on satisfaction and quality of life (QoL). MATERIALS AND METHODS: The literature search for relevant articles published between January 1983 and March 30, 2013 was conducted using keyword searches of electronic databases and complimentary hand searches. The search strategy included the following keyword combinations (MeSH and free-text terms): fail, complication, surviv*, longevity, outcome, patient satisfaction or QoL, and denture or prosthes*, and partial and removable...
January 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27479759/multi-technique-approach-for-qualitative-and-quantitative-characterization-of-furazidin-degradation-kinetics-under-alkaline-conditions
#9
Kārlis Bērziņš, Artis Kons, Ilze Grante, Diana Dzabijeva, Ilva Nakurte, Andris Actiņš
Degradation of drug furazidin was studied under different conditions of environmental pH (11-13) and temperature (30-60°C). The novel approach of hybrid hard- and soft-multivariate curve resolution-alternating least squares (HS-MCR-ALS) method was applied to UV-vis spectral data to determine a valid kinetic model and kinetic parameters of the degradation process. The system was found to be comprised of three main species and best characterized by two consecutive first-order reactions. Furazidin degradation rate was found to be highly dependent on the applied environmental conditions, showing more prominent differences between both degradation steps towards higher pH and temperature...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27466331/multiple-mechanisms-for-processing-reward-uncertainty-in-the-primate-basal-forebrain
#10
Noah M Ledbetter, Charles D Chen, Ilya E Monosov
UNLABELLED: The ability to use information about the uncertainty of future outcomes is critical for adaptive behavior in an uncertain world. We show that the basal forebrain (BF) contains at least two distinct neural-coding strategies to support this capacity. The dorsal-lateral BF, including the ventral pallidum (VP), contains reward-sensitive neurons, some of which are selectively suppressed by uncertain-reward predictions (U(-)). In contrast, the medial BF (mBF) contains reward-sensitive neurons, some of which are selectively enhanced (U(+)) by uncertain-reward predictions...
July 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27375833/the-role-of-imaging-in-aortic-valve-disease
#11
REVIEW
Russell J Everett, David E Newby, Andrew Jabbour, Zahi A Fayad, Marc R Dweck
PURPOSE OF REVIEW: Aortic valve disease is the most common form of heart valve disease in developed countries. Imaging remains central to the diagnosis and risk stratification of patients with both aortic stenosis and regurgitation and has traditionally been performed with echocardiography. Indeed, echocardiography remains the cornerstone of aortic valve imaging as it is cheap, widely available and provides critical information concerning valve hemodynamics and ventricular function. RECENT FINDINGS: Whilst diagnostic in the vast majority of patients, echocardiography has certain limitations including operator variability, potential for measurement errors and internal inconsistencies in severity grading...
2016: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/27351465/environmental-and-pharmacological-manipulations-blunt-the-stress-response-of-zebrafish-in-a-similar-manner
#12
Ana Cristina V V Giacomini, Murilo S Abreu, Rodrigo Zanandrea, Natália Saibt, Maria Tereza Friedrich, Gessi Koakoski, Darlan Gusso, Angelo L Piato, Leonardo J G Barcellos
Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish. Different groups of fish were maintained isolated or group-housed in barren or enriched tanks, and then exposed or not to diazepam or fluoxetine. Acute stress increased cortisol levels in group-housed zebrafish maintained in barren environment. Single-housed zebrafish displayed a blunted cortisol response to stress. Environmental enrichment also blunted the stress response and this was observed in both isolated and group-housed fish...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27333988/outcomes-of-anatomical-vs-functional-testing-for-coronary-artery-disease-lessons-from-the-promise-trial
#13
R Shah, B Foldyna, U Hoffmann
The development of coronary artery disease (CAD) is a major, final common pathway in heart disease worldwide. With a rise in stress testing and increased scrutiny on cost-effectiveness and radiation exposure in medical imaging, a focus on the relative merits of anatomic versus functional characterization of CAD has emerged. In this context, coronary computed tomography angiography (CCTA) is a noninvasive alternative to functional testing as a first-line test for CAD detection but is complimentary in its nature...
August 2016: Herz
https://www.readbyqxmd.com/read/27317046/in%C3%A2-vivo-oximetry-of-human-bulbar-conjunctival-and-episcleral-microvasculature-using-snapshot-multispectral-imaging
#14
L E MacKenzie, T R Choudhary, A I McNaught, A R Harvey
Multispectral imaging (MSI) is a well-established technique for non-invasive oximetry of retinal blood vessels, which has contributed to the understanding of a variety of retinal conditions, including glaucoma, diabetes, vessel occlusion, and retinal auto-regulation. We report the first study to use snapshot multi-spectral imaging (SMSI) for oximetry of the bulbar conjunctival and episcleral microvasculature in the anterior segment of the eye. We report the oxygen dynamics of the bulbar conjunctival and episcleral microvasculature at normoxia and at acute mild hypoxia conditions...
August 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27277033/dosimetric-comparison-of-stopping-power-calibration-with-dual-energy-ct-and-single-energy-ct-in-proton-therapy-treatment-planning
#15
COMPARATIVE STUDY
Jiahua Zhu, Scott N Penfold
PURPOSE: The accuracy of proton dose calculation is dependent on the ability to correctly characterize patient tissues with medical imaging. The most common method is to correlate computed tomography (CT) numbers obtained via single-energy CT (SECT) with proton stopping power ratio (SPR). CT numbers, however, cannot discriminate between a change in mass density and change in chemical composition of patient tissues. This limitation can have consequences on SPR calibration accuracy. Dual-energy CT (DECT) is receiving increasing interest as an alternative imaging modality for proton therapy treatment planning due to its ability to discriminate between changes in patient density and chemical composition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27257066/quantitative-modeling-of-gene-expression-using-dna-shape-features-of-binding-sites
#16
Pei-Chen Peng, Saurabh Sinha
Prediction of gene expression levels driven by regulatory sequences is pivotal in genomic biology. A major focus in transcriptional regulation is sequence-to-expression modeling, which interprets the enhancer sequence based on transcription factor concentrations and DNA binding specificities and predicts precise gene expression levels in varying cellular contexts. Such models largely rely on the position weight matrix (PWM) model for DNA binding, and the effect of alternative models based on DNA shape remains unexplored...
July 27, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27140958/the-use-of-breathing-exercises-in-the-treatment-of-chronic-non-specific-low-back-pain
#17
Barton E Anderson, Kellie C Huxel Bliven
Research has demonstrated a relationship between poor core stability and back pain, with noted decreases in core muscle activity and spinal stabilization in those suffering from both acute and chronic conditions. This relationship has also led to studies examining differences in breathing patterns between persons with and without low back pain. Several authors have reported altered breathing patterns in persons with chronic, non-specific low back pain, including differences in lung capacity and diaphragm mechanics...
May 2, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27135483/optimizing-treatment-with-tnf-inhibitors-in-inflammatory-bowel-disease-by-monitoring-drug-levels-and-antidrug-antibodies
#18
Casper Steenholdt, Klaus Bendtzen, Jørn Brynskov, Mark A Ainsworth
BACKGROUND: Biological tumor necrosis factor (TNF) inhibitors have revolutionized the treatment of inflammatory bowel disease and redefined treatment goals to include mucosal healing. Clinicians are faced with challenges such as inadequate responses, treatment failures, side effects, and high drug costs. The objective is to review optimization of anti-TNF therapy by use of personalized treatment strategies based on circulating drug levels and antidrug antibodies (Abs), i.e. therapeutic drug monitoring (TDM)...
August 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27080384/write-draw-show-and-tell-a-child-centred-dual-methodology-to-explore-perceptions-of-out-of-school-physical-activity
#19
Robert J Noonan, Lynne M Boddy, Stuart J Fairclough, Zoe R Knowles
BACKGROUND: Research to increase children's physical activity and inform intervention design has, to date, largely underrepresented children's voices. Further, research has been limited to singular qualitative methods that overlook children's varied linguistic ability and interaction preference. The aim of this study was to use a novel combination of qualitative techniques to explore children's current views, experiences and perceptions of out-of-school physical activity as well as offering formative opinion about future intervention design...
April 14, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27065835/transcranial-alternating-current-stimulation-with-sawtooth-waves-simultaneous-stimulation-and-eeg-recording
#20
James Dowsett, Christoph S Herrmann
Transcranial alternating current stimulation (tACS) has until now mostly been administered as an alternating sinusoidal wave. Despite modern tACS stimulators being able to deliver alternating current with any arbitrary shape there has been no systematic exploration into the relative benefits of different waveforms. As tACS is a relatively new technique there is a huge parameter space of unexplored possibilities which may prove superior or complimentary to the traditional sinusoidal waveform. Here, we begin to address this with an investigation into the effects of sawtooth wave tACS on individual alpha power...
2016: Frontiers in Human Neuroscience
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