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https://www.readbyqxmd.com/read/28150906/insulin-like-growth-factor-binding-protein-4-inhibits-cell-growth-migration-and-invasion-and-downregulates-cox-2-expression-in-a549-lung-cancer-cells
#1
Weiwen Li, Debin Sun, Zhuqing Lv, Yueqiu Wei, Liyun Zheng, Tingting Zeng, Jialu Zhao
Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues...
February 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28143425/higher-igfbp-1-to-igf-1-serum-ratio-predicts-unfavourable-survival-in-patients-with-nasopharyngeal-carcinoma
#2
Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu, Ge Zhang
BACKGROUND: The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopathological significance and prognostic value in nasopharyngeal carcinoma (NPC). METHODS: IGF system components (IGF-1, IGF-2, IGF-1SR, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-6) were quantified from the plasma of NPC patients and healthy individuals using the RayBio Human Cytokine Antibody Array...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28116872/recent-insights-into-insulin-like-growth-factor-binding-protein-2-transcriptional-regulation
#3
REVIEW
Minsang Shin, Hye Suk Kang, Jae Hyung Park, Jae Hoon Bae, Dae Kyu Song, Seung Soon Im
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region...
January 19, 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28104361/igfbp-a-novel-target-of-lung-cancer
#4
REVIEW
Qiongge Hu, Yong Zhou, Kejing Ying, Wenjing Ruan
The insulin-like growth factor-1 receptor (IGF-1R) is a central component of lung cancer signal transduction pathways. A phase III study failed for carboplatin, paclitaxel, with or without figitumumab in first-line treating metastatic non-small cell lung cancer (NSCLC). There is an urgent need for a better understanding of signaling in IGF system. Insulin-like growth factor-binding proteins (IGFBPs) function as modulators for IGF signaling through sequestration of IGFs in serum and the extracellular fluid. IGFBPs can also act as transporters or modulators for IGF action and insulin action...
January 17, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28096479/igf-1-receptor-modulates-foxo1-mediated-tamoxifen-response-in-breast-cancer-cells
#5
Ali Vaziri-Gohar, Yan Zheng, Kevin D Houston
: Tamoxifen is a common adjuvant treatment for ERalpha-positive breast cancer patients, however acquired resistance abrogates the efficacy of this therapeutic approach. We recently demonstrated that G protein-coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor binding protein-1 (IGFBP-1) to inhibit IGF-1-dependent signaling. To determine if dysregulation of IGFBP-1 induction is associated with tamoxifen resistance, IGFBP-1 transcription was measured in tamoxifen-resistant MCF-7 cells (TamR) after tamoxifen (Tam) treatment...
January 17, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28008951/the-c-terminus-of-igfbp-5-suppresses-tumor-growth-by-inhibiting-angiogenesis
#6
Jae Ryoung Hwang, Young-Jae Cho, Yoonna Lee, Youngmee Park, Hee Dong Han, Hyung Jun Ahn, Je-Ho Lee, Jeong-Won Lee
Insulin-like growth factor-binding protein 5 (IGFBP-5) plays a role in cell growth, differentiation, and apoptosis. In this study, we found that IGFBP5 was markedly downregulated in ovarian cancer tissue. We investigated the functional significance of IGFBP-5 as a tumor suppressor. To determine functional regions of IGFBP-5, truncation mutants were prepared and were studied the effect on tumor growth. Expression of C-terminal region of IGFBP-5 significantly decreased tumor growth in an ovarian cancer xenograft...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998647/glucose-metabolism-during-the-acute-prostate-cancer-treatment-trajectory-the-influence-of-age-and-obesity
#7
Katie M Di Sebastiano, Kirsten E Bell, Andrew S Mitchell, Joe Quadrilatero, Joel A Dubin, Marina Mourtzakis
BACKGROUND & AIMS: Obesity and age, key risk factors for aggressive prostate cancer, are associated with insulin resistance. Glucose-related parameters in patients with aggressive prostate cancer were compared with 2 reference groups: men of similar age and body mass index (BMI) without cancer, and healthy young men. Acute changes in these parameters following radiation treatment were also evaluated. METHODS: Nine patients with aggressive prostate cancer underwent metabolic assessments prior to treatment (baseline), 7 and 33 weeks post-baseline (post-treatment initiation)...
December 2, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27978831/the-low-igfbp-3-level-is-associated-with-esophageal-cancer-patients-a-meta-analysis
#8
Guiqin Song, Kang Liu, Xiaoyan Zhu, Xiaolin Yang, Yuewu Shen, Wan Wang, Guidong Shi, Qing Li, Yi Duan, Yunxia Zhao, Gang Feng
BACKGROUND: Esophageal cancer was a vital cause of cancer-related mortality worldwide, and the insulin-like growth factor-binding proteins (IGFBPs) has been proved to be an important factor of multiple types of tumors. There is a controversy that whether the IGFBP-3 level is associated with the clinical pathological characteristics and overall survival of esophageal cancer patients. Herein, we aimed to comprehensively assess the association between the low IGFBP-3 level and the risk, overall survival and clinical pathological characteristics of esophageal cancer...
December 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27930694/influence-of-fasting-status-and-sample-preparation-on-metabolic-biomarker-measurements-in-postmenopausal-women
#9
Neil Murphy, Roni T Falk, Diana B Messinger, Michael Pollak, Xiaonan Xue, Juan Lin, Robin Sgueglia, Howard D Strickler, Mia M Gaudet, Marc J Gunter
BACKGROUND: Epidemiologic data linking metabolic markers-such as insulin, insulin-like growth factors (IGFs)-and adipose tissue-derived factors with cancer are inconsistent. Between-study differences in blood collection protocols, in particular participant's fasting status, may influence measurements. METHODS: We investigated the impact of fasting status and blood sample processing time on components of the insulin/IGF axis and in adipokines in a controlled feeding study of 45 healthy postmenopausal-women aged 50-75 years...
2016: PloS One
https://www.readbyqxmd.com/read/27823741/insulin-growth-factor-igf-1-igf-binding-proteins-and-ovarian-cancer-risk-a-systematic-review-and-meta-analysis
#10
REVIEW
Ximena Gianuzzi, Gabriela Palma-Ardiles, Wendy Hernandez-Fernandez, Vinay Pasupuleti, Adrian V Hernandez, Faustino R Perez-Lopez
BACKGROUND: Insulin resistance (IR) has been implicated in carcinogenesis, but there is no consensus regarding its involvement in ovarian cancer. We performed a systematic review and meta-analysis to evaluate the association between IR and ovarian cancer. METHODS: Searches were conducted in five databases for studies evaluating IR markers (levels of serum insulin, C peptide, insulin growth factor [IGF] 1 and IGF-binding proteins [IGFBPs], homeostatic model assessment insulin resistance, and quantitative insulin-sensitivity check index) and ovarian cancer risk...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27754854/hyperglycaemia-induced-resistance-to-docetaxel-is-negated-by-metformin-a-role-for-igfbp-2
#11
K M Biernacka, R A Persad, A Bahl, D Gillatt, J M P Holly, C M Perks
The incidence of many common cancers varies between different populations and appears to be affected by a Western lifestyle. Highly proliferative malignant cells require sufficient levels of nutrients for their anabolic activity. Therefore, targeting genes and pathways involved in metabolic pathways could yield future therapeutics. A common pathway implicated in energetic and nutritional requirements of a cell is the LKB1/AMPK pathway. Metformin is a widely studied anti-diabetic drug, which improves glycaemia in patients with type 2 diabetes by targeting this pathway...
January 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27687550/a-to-i-rna-editing-of-the-igfbp7-transcript-increases-during-aging-in-porcine-brain-tissues
#12
Knud Larsen, Kaja Kjær Kristensen, Jamal Momeni, Leila Farajzadeh, Christian Bendixen
The IGFBP7 gene encodes insulin-like growth factor protein 7. IGFPB7 is involved in diverse biological functions including cell growth regulation, senescence and apoptosis, and also acts as a tumor suppressor in multiple cancers. The IGFBP7 mRNA is subject to A-to-I RNA editing mediated by adenosine deaminases acting on RNA 1 and 2 (ADAR1 and ADAR2). In the current study we have examined molecular characteristics of the porcine IGFBP7 gene, and determined the mRNA editing in different tissues. The A-to-I RNA editing of human IGFBP7 in positions Arg78 and Lys95 was shown to be conserved in the porcine homologue...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27681092/current-ideas-on-the-biology-of-igfbp-6-more-than-an-igf-ii-inhibitor
#13
REVIEW
Leon A Bach
IGFBP-6 binds IGF-II with higher affinity than IGF-I and it is a relatively specific inhibitor of IGF-II actions. More recently, IGFBP-6 has also been reported to have IGF-independent effects on cell proliferation, survival, differentiation and migration. IGFBP-6 binds to several ligands in the extracellular space, cytoplasm and nucleus. These interactions, together with activation of distinct intracellular signaling pathways, may contribute to its IGF-independent actions; for example, IGF-independent migration induced by IGFBP-6 involves interaction with prohibitin-2 and activation of MAP kinase pathways...
October 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27644646/association-of-igfbp-6-expression-with-metabolic-syndrome-and-adiponectin-and-igf-ir-receptor-levels-in-colorectal-cancer
#14
Natalia V Yunusova, Liudmila V Spirina, Alena E Frolova, Sergey G Afanas'ev, Elena S Kolegova, Irina V Kondakova
PURPOSE: To assess IGFBP-6 expression in relation with the presence of the metabolic syndrome, adiponectin receptors (AdipoR1 and AdipoR2) and IGF-IR levels in colorectal adenocarcinoma cases. MATERIALS AND METHODS: IGFBP-6 mRNA and protein levels were analyzed using real-time quantitative PCR and Western blotting in 46 patients. ELISA and ow cytometry were used for evaluation of AdipoR1, AdipoR2 and IGF-IR. RESULTS: The results showed that IGFBP-6 mRNA expression and the IGFBP-6 content were higher in tumor tissue samples of colorectal cancer patients with and without the metabolic syndrome...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27631779/effects-of-high-order-interactions-among-igfbp-3-genetic-polymorphisms-body-mass-index-and-soy-isoflavone-intake-on-breast-cancer-susceptibility
#15
Qiong Wang, Li Liu, Hui Li, Ping Tao, Yana Qi, Jiayuan Li
BACKGROUND: Polymorphisms of IGF-1 and IGFBP-3 and environmental factors may work together to influence insulin-like growth factor (IGF) levels and thus breast cancer (BC) risk. However, very few studies have investigated high-order interactions among these variables. METHODS: A total of 277 newly diagnosed BC cases and 277 controls were recruited between October 2010 and July 2012. We collected each participant's demographic characteristics, dietary intake, and blood sample...
2016: PloS One
https://www.readbyqxmd.com/read/27629137/does-igf-1-play-a-role-in-the-biology-of-endometrial-cancer
#16
Dominika Majchrzak-Baczmańska, Andrzej Malinowski
Insulin-like growth factor 1 (IGF-1) is a mitogen which plays a key role in regulating cell proliferation, differentiation, and apoptosis. It belongs to the family of proteins also composed of insulin-like growth factor 2 (IGF-2), two types of membrane receptors (IGF-1R and IGF-2R), 6 binding proteins (IGFBP 1-6), hydrolyzing proteases, and reactive molecules binding proteins, which regulate the activity of growth factors. Disturbances in the functioning of IGFBP/IGF/1GF1R can lead to induction of carcinogenesis, which has been demonstrated in breast, prostate or colon cancers...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27579675/identification-of-igfbp2-and-igfbp3-as-compensatory-biomarkers-for-ca19-9-in-early-stage-pancreatic-cancer-using-a-combination-of-antibody-based-and-lc-ms-ms-based-proteomics
#17
Toshihiro Yoneyama, Sumio Ohtsuki, Kazufumi Honda, Makoto Kobayashi, Motoki Iwasaki, Yasuo Uchida, Takuji Okusaka, Shoji Nakamori, Masashi Shimahara, Takaaki Ueno, Akihiko Tsuchida, Naohiro Sata, Tatsuya Ioka, Yohichi Yasunami, Tomoo Kosuge, Takashi Kaneda, Takao Kato, Kazuhiro Yagihara, Shigeyuki Fujita, Wilber Huang, Tesshi Yamada, Masanori Tachikawa, Tetsuya Terasaki
Pancreatic cancer is one of the most lethal tumors, and reliable detection of early-stage pancreatic cancer and risk diseases for pancreatic cancer is essential to improve the prognosis. As 260 genes were previously reported to be upregulated in invasive ductal adenocarcinoma of pancreas (IDACP) cells, quantification of the corresponding proteins in plasma might be useful for IDACP diagnosis. Therefore, the purpose of the present study was to identify plasma biomarkers for early detection of IDACP by using two proteomics strategies: antibody-based proteomics and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics...
2016: PloS One
https://www.readbyqxmd.com/read/27562357/the-insulin-like-growth-factor-system-is-modulated-by-exercise-in-breast-cancer-survivors-a-systematic-review-and-meta-analysis
#18
José Francisco Meneses-Echávez, Emilio González Jiménez, Jacqueline Schmidt Río-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Robinson Ramírez-Vélez
BACKGROUND: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. METHODS: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27528036/pregnancy-specific-glycoprotein-9-psg9-a-driver-for-colorectal-cancer-enhances-angiogenesis-via-activation-of-smad4
#19
Lei Yang, Shusheng Hu, Jinjing Tan, Xiaojing Zhang, Wen Yuan, Qian Wang, Lingling Xu, Jian Liu, Zheng Liu, Yanjun Jia, Xiaoxi Huang
PSG9 is a member of the pregnancy-specific glycoprotein (PSG) family and has been shown to contribute to the progression of colorectal cancer (CRC) and cancer-related angiogenesis. Here, we aim to investigate abnormal PSG9 levels in patients with CRC and to emphasize the role of PSG9 in driving tumorigenesis. Serum from 140 patients with CRC and 125 healthy controls as well as 74 paired tumors and adjacent normal tissue were used to determine PSG9 levels. We discovered that PSG9 was significantly increased in serum (P<0...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27525640/decreased-levels-of-circulating-cancer-associated-protein-biomarkers-following-bariatric-surgery
#20
John Edward Farey, Oliver M Fisher, Angelique J Levert-Mignon, Patrice M Forner, Reginald V Lord
BACKGROUND: Epidemiological studies have identified obesity as a major risk factor for cancer in humans, and trials have demonstrated a significant reduction in the incidence of cancer after bariatric surgery. The rapidity of weight loss after bariatric surgery provides an opportunity to identify the molecular changes associated with effective obesity treatment. Indirectly, this may provide some insights into the mechanisms that drive the association between obesity and cancer. We sought to measure circulating cancer-associated proteins before and after laparoscopic sleeve gastrectomy (LSG)...
March 2017: Obesity Surgery
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