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https://www.readbyqxmd.com/read/28420208/serum-insulin-like-growth-factor-axis-and-the-risk-of-pancreatic-cancer-systematic-review-and-meta-analysis
#1
Yuanfeng Gong, Bingyi Zhang, Yadi Liao, Yunqiang Tang, Cong Mai, Tiejun Chen, Hui Tang
OBJECTIVE: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). METHODS: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I² statistics...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28417914/interactions-of-the-insulin-like-growth-factor-axis-and-vitamin-d-in-prostate-cancer-risk-in-the-prostate-cancer-prevention-trial
#2
Fayth L Miles, Phyllis J Goodman, Catherine Tangen, Kathleen C Torkko, Jeannette M Schenk, Xiaoling Song, Michael Pollak, Ian M Thompson, Marian L Neuhouser
Some, but not all, epidemiologic studies report an association between vitamin D and prostate cancer risk. The inconsistent findings might be explained in the context of modification by members of the insulin-like growth factor (IGF) axis. Data and specimens for this nested case-control study (n = 1695 cases and n = 1682 controls) are from the Prostate Cancer Prevention Trial (PCPT). Baseline serum samples were assayed for 25(OH)D, IGF-1, IGF-2, IGFBP-2, IGFBP-3, and the ratio of IGF1:BP3, along with insulin-related markers c-peptide and leptin...
April 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28366834/the-wilms-tumor-protein-wt1-stimulates-transcription-of-the-gene-encoding-insulin-like-growth-factor-binding-protein-5-igfbp5
#3
Miriam Müller, Anja Bondke Persson, Katharina Krueger, Karin M Kirschner, Holger Scholz
Insulin-like growth factor (IGF) binding proteins (IGFBPs) constitute a family of six secreted proteins that regulate the signaling of insulin-like growth factors (IGFs). IGFBP5 is the most conserved family member in vertebrates and the major IGF binding protein in bone. IGFBP5 is required for normal development of the musculoskeletal system, and various types of cancer frequently express high levels of IGFP5. Here we identify the gene encoding IGFBP5 as a novel downstream target of the Wilms tumor protein WT1...
March 30, 2017: Gene
https://www.readbyqxmd.com/read/28363795/glucagon-like-petide-2-acts-on-colon-cancer-myofibroblasts-to-stimulate-proliferation-migration-and-invasion-of-both-myofibroblasts-and-cancer-cells-via-the-igf-pathway
#4
Marianne Shawe-Taylor, J Dinesh Kumar, Whitney Holden, Steven Dodd, Akos Varga, Olivier Giger, Andrea Varro, Graham J Dockray
Glucagon-like peptide (GLP)-2 stimulates intestinal epithelial proliferation by acting, in part, via IGF release from sub-epithelial myofibroblasts. The response of myofibroblasts to GLP-2 remains incompletely understood. We studied the action of GLP-2 on myofibroblasts from colon cancer and adjacent tissue, and the effects of conditioned medium from these cells on epithelial cell proliferation, migration and invasion. GLP-2 stimulated proliferation, migration and invasion of myofibroblasts and the proliferative and invasive responses of cancer-associated myofibroblasts were greater than those of myofibroblasts from adjacent tissue...
March 29, 2017: Peptides
https://www.readbyqxmd.com/read/28361446/does-milk-intake-promote-prostate-cancer-initiation-or-progression-via-effects-on-insulin-like-growth-factors-igfs-a-systematic-review-and-meta-analysis
#5
REVIEW
Sean Harrison, Rosie Lennon, Jeff Holly, Julian P T Higgins, Mike Gardner, Claire Perks, Tom Gaunt, Vanessa Tan, Cath Borwick, Pauline Emmet, Mona Jeffreys, Kate Northstone, Sabina Rinaldi, Stephen Thomas, Suzanne D Turner, Anna Pease, Vicky Vilenchick, Richard M Martin, Sarah J Lewis
PURPOSE: To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3). METHODS: Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise...
March 30, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28344885/pappalysin-1-t-cell-receptor-transgenic-allo-restricted-t-cells-kill-ewing-sarcoma-in-vitro-and-in-vivo
#6
Andreas Kirschner, Melanie Thiede, Thomas G P Grünewald, Rebeca Alba Rubio, Günther H S Richter, Thomas Kirchner, Dirk H Busch, Stefan Burdach, Uwe Thiel
Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF inhibitors, i.e., IGF binding proteins (IGFBPs), thereby setting free IGFs. The insulin/IGF-axis is involved in cancer in general and in Ewing sarcoma (ES) in particular. ES is a highly malignant bone tumor characterized by early metastatic spread. PAPPA is associated with various cancers. It is overexpressed and required for proliferation in ES...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28335515/dehydroepiandrosterone-dhea-feeding-protects-liver-steatosis-in-obese-breast-cancer-rat-model
#7
Reza Hakkak, Andrea Bell, Soheila Korourian
Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used as an anti-obesity supplement. Previously, we reported that DHEA feeding protects 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. The objectives of this study were to investigate the effects of obesity and DHEA feeding on liver steatosis, body weight gain, and serum DHEA, DHEA sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) levels...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28325826/a-phase-ii-randomized-double-blind-presurgical-trial-of-polyphenon-e-in-bladder-cancer-patients-to-evaluate-pharmacodynamics-and-bladder-tissue-biomarkers
#8
Jason R Gee, Daniel R Saltzstein, KyungMann Kim, Jill M Kolesar, Wei Huang, Thomas C Havighurst, Barbara W Wollmer, Jeanne Stublaski, Tracy Downs, Hasan Mukhtar, Margaret House, Howard L Parnes, Howard H Bailey
We performed a phase 2 pharmacodynamic, prevention trial of Polyphenon E® (a green tea polyphenol formulation primarily consisting of epigallocatechin gallate (EGCG)) in patients prior to bladder cancer surgery. Patients with a bladder tumor were randomized to receive Polyphenon E® containing either 800 or 1200 mg of EGCG or placebo for 14 to 28 days prior to TURBT or cystectomy. The primary objective was to compare the post-intervention EGCG tissue levels in patients receiving Polyphenon E® as compared to placebo...
March 21, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28258988/serum-igf-1-igfbp-3-levels-and-circulating-tumor-cells-ctcs-in-early-breast-cancer-patients
#9
Georgios Z Papadakis, Dimitrios Mavroudis, Vasilios Georgoulias, John Souglakos, Athanasios K Alegakis, George Samonis, Ulas Bagci, Antonis Makrigiannakis, Odysseas Zoras
OBJECTIVE: Insulin-like growth factor (IGF)-axis is involved in human oncogenesis and metastasis development for various solid tumors including breast cancer. Aim of this study was to assess the association between IGF-1, IGF-binding protein-3 (IGFBP-3) serum levels and the presence of circulating tumor cells (CTCs) in the peripheral blood of women diagnosed with early breast cancer (EBC), before and after adjuvant chemotherapy. DESIGN: 171 patients with early-stage breast adenocarcinomas were retrospectively evaluated...
February 16, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28150906/insulin-like-growth-factor-binding-protein-4-inhibits-cell-growth-migration-and-invasion-and-downregulates-cox-2-expression-in-a549-lung-cancer-cells
#10
Weiwen Li, Debin Sun, Zhuqing Lv, Yueqiu Wei, Liyun Zheng, Tingting Zeng, Jialu Zhao
Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues...
April 2017: Cell Biology International
https://www.readbyqxmd.com/read/28143425/higher-igfbp-1-to-igf-1-serum-ratio-predicts-unfavourable-survival-in-patients-with-nasopharyngeal-carcinoma
#11
Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu, Ge Zhang
BACKGROUND: The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopathological significance and prognostic value in nasopharyngeal carcinoma (NPC). METHODS: IGF system components (IGF-1, IGF-2, IGF-1SR, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-6) were quantified from the plasma of NPC patients and healthy individuals using the RayBio Human Cytokine Antibody Array...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28116872/recent-insights-into-insulin-like-growth-factor-binding-protein-2-transcriptional-regulation
#12
REVIEW
Minsang Shin, Hye Suk Kang, Jae Hyung Park, Jae Hoon Bae, Dae Kyu Song, Seung Soon Im
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28104361/igfbp-a-novel-target-of-lung-cancer
#13
REVIEW
Qiongge Hu, Yong Zhou, Kejing Ying, Wenjing Ruan
The insulin-like growth factor-1 receptor (IGF-1R) is a central component of lung cancer signal transduction pathways. A phase III study failed for carboplatin, paclitaxel, with or without figitumumab in first-line treating metastatic non-small cell lung cancer (NSCLC). There is an urgent need for a better understanding of signaling in IGF system. Insulin-like growth factor-binding proteins (IGFBPs) function as modulators for IGF signaling through sequestration of IGFs in serum and the extracellular fluid. IGFBPs can also act as transporters or modulators for IGF action and insulin action...
March 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28096479/igf-1-receptor-modulates-foxo1-mediated-tamoxifen-response-in-breast-cancer-cells
#14
Ali Vaziri-Gohar, Yan Zheng, Kevin D Houston
Tamoxifen is a common adjuvant treatment for estrogen receptor (ER)α-positive patients with breast cancer; however, acquired resistance abrogates the efficacy of this therapeutic approach. We recently demonstrated that G protein-coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor-binding protein-1 (IGFBP-1) to inhibit IGF-1-dependent signaling. To determine whether dysregulation of IGFBP-1 induction is associated with tamoxifen resistance, IGFBP-1 transcription was measured in tamoxifen-resistant MCF-7 cells (TamR) after tamoxifen (Tam) treatment...
April 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28008951/the-c-terminus-of-igfbp-5-suppresses-tumor-growth-by-inhibiting-angiogenesis
#15
Jae Ryoung Hwang, Young-Jae Cho, Yoonna Lee, Youngmee Park, Hee Dong Han, Hyung Jun Ahn, Je-Ho Lee, Jeong-Won Lee
Insulin-like growth factor-binding protein 5 (IGFBP-5) plays a role in cell growth, differentiation, and apoptosis. In this study, we found that IGFBP5 was markedly downregulated in ovarian cancer tissue. We investigated the functional significance of IGFBP-5 as a tumor suppressor. To determine functional regions of IGFBP-5, truncation mutants were prepared and were studied the effect on tumor growth. Expression of C-terminal region of IGFBP-5 significantly decreased tumor growth in an ovarian cancer xenograft...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998647/glucose-metabolism-during-the-acute-prostate-cancer-treatment-trajectory-the-influence-of-age-and-obesity
#16
Katie M Di Sebastiano, Kirsten E Bell, Andrew S Mitchell, Joe Quadrilatero, Joel A Dubin, Marina Mourtzakis
BACKGROUND & AIMS: Obesity and age, key risk factors for aggressive prostate cancer, are associated with insulin resistance. Glucose-related parameters in patients with aggressive prostate cancer were compared with 2 reference groups: men of similar age and body mass index (BMI) without cancer, and healthy young men. Acute changes in these parameters following radiation treatment were also evaluated. METHODS: Nine patients with aggressive prostate cancer underwent metabolic assessments prior to treatment (baseline), 7 and 33 weeks post-baseline (post-treatment initiation)...
December 2, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27978831/the-low-igfbp-3-level-is-associated-with-esophageal-cancer-patients-a-meta-analysis
#17
Guiqin Song, Kang Liu, Xiaoyan Zhu, Xiaolin Yang, Yuewu Shen, Wan Wang, Guidong Shi, Qing Li, Yi Duan, Yunxia Zhao, Gang Feng
BACKGROUND: Esophageal cancer was a vital cause of cancer-related mortality worldwide, and the insulin-like growth factor-binding proteins (IGFBPs) has been proved to be an important factor of multiple types of tumors. There is a controversy that whether the IGFBP-3 level is associated with the clinical pathological characteristics and overall survival of esophageal cancer patients. Herein, we aimed to comprehensively assess the association between the low IGFBP-3 level and the risk, overall survival and clinical pathological characteristics of esophageal cancer...
December 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27930694/influence-of-fasting-status-and-sample-preparation-on-metabolic-biomarker-measurements-in-postmenopausal-women
#18
Neil Murphy, Roni T Falk, Diana B Messinger, Michael Pollak, Xiaonan Xue, Juan Lin, Robin Sgueglia, Howard D Strickler, Mia M Gaudet, Marc J Gunter
BACKGROUND: Epidemiologic data linking metabolic markers-such as insulin, insulin-like growth factors (IGFs)-and adipose tissue-derived factors with cancer are inconsistent. Between-study differences in blood collection protocols, in particular participant's fasting status, may influence measurements. METHODS: We investigated the impact of fasting status and blood sample processing time on components of the insulin/IGF axis and in adipokines in a controlled feeding study of 45 healthy postmenopausal-women aged 50-75 years...
2016: PloS One
https://www.readbyqxmd.com/read/27823741/insulin-growth-factor-igf-1-igf-binding-proteins-and-ovarian-cancer-risk-a-systematic-review-and-meta-analysis
#19
REVIEW
Ximena Gianuzzi, Gabriela Palma-Ardiles, Wendy Hernandez-Fernandez, Vinay Pasupuleti, Adrian V Hernandez, Faustino R Perez-Lopez
BACKGROUND: Insulin resistance (IR) has been implicated in carcinogenesis, but there is no consensus regarding its involvement in ovarian cancer. We performed a systematic review and meta-analysis to evaluate the association between IR and ovarian cancer. METHODS: Searches were conducted in five databases for studies evaluating IR markers (levels of serum insulin, C peptide, insulin growth factor [IGF] 1 and IGF-binding proteins [IGFBPs], homeostatic model assessment insulin resistance, and quantitative insulin-sensitivity check index) and ovarian cancer risk...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27754854/hyperglycaemia-induced-resistance-to-docetaxel-is-negated-by-metformin-a-role-for-igfbp-2
#20
K M Biernacka, R A Persad, A Bahl, D Gillatt, J M P Holly, C M Perks
The incidence of many common cancers varies between different populations and appears to be affected by a Western lifestyle. Highly proliferative malignant cells require sufficient levels of nutrients for their anabolic activity. Therefore, targeting genes and pathways involved in metabolic pathways could yield future therapeutics. A common pathway implicated in energetic and nutritional requirements of a cell is the LKB1/AMPK pathway. Metformin is a widely studied anti-diabetic drug, which improves glycaemia in patients with type 2 diabetes by targeting this pathway...
January 2017: Endocrine-related Cancer
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