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https://www.readbyqxmd.com/read/30024944/small-molecule-disruption-of-g-protein-%C3%AE-%C3%AE-subunit-signaling-reprograms-human-macrophage-phenotype-and-prevents-autoimmune-myocarditis-in-rats
#1
Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A Youker, Suresh S Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L Spiller, Kenichi Watanabe, Rajarajan A Thandavarayan
The purpose of this study was to determine whether blocking of G protein βγ (Gβγ) signaling halts heart failure (HF) progression by macrophage phenotype manipulation. Cardiac Gβγ signaling plays a crucial role in HF pathogenesis. Previous data suggested that inhibiting Gβγ signaling reprograms T helper cell 1 (Th1) and Th2 cytokines, suggesting that Gβγ might be a useful drug target for treating HF. We investigated the efficacy of a small molecule Gβγ inhibitor, gallein, in a clinically relevant, experimental autoimmune myocarditis (EAM) model of HF as well as in human macrophage phenotypes in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/30024553/zhenwu-decoction-for-chronic-heart-failure-protocol-for-a-systematic-review-and-meta-analysis
#2
Qi Tang, Yuanping Wang, Kuangyi Li
BACKGROUND: Chronic heart failure (CHF), not only a severe personal healthy problem but also a social financial burden, has become a global health concern. Zhenwu decoction (ZWD) has been widely adopted to clinical practice for patients with CHF. It is necessary to update the researches to reevaluate the efficacy and safety of ZWD to provide the up-to-date evidence for CHF management. Therefore, we provide a protocol of systematic review regarding ZWD for CHF. METHODS: The aim of this study was to retrieve papers on the topic of ZWD treatment for CHF in the electrical databases, including PubMed, Cochrane Library, EMBASE, Chinese Biomedical database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Science and Technology Periodical database (VIP)...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30024423/cardiovascular-aging-the-unveiled-enigma-from-bench-to-bedside
#3
Antonio Cannata', Marco Merlo, Jessica Artico, Piero Gentile, Luca Camparini, Jacopo Cristallini, Aldostefano Porcari, Francesco Loffredo, Gianfranco Sinagra
: The rapid increase in the median age of the world's population requires particular attention towards older and more fragile people. Cardiovascular risk factors, time and comorbidities play a vicious role in the development of heart failure, both with reduced and preserved ejection fraction, in the elderly. Understanding the mechanisms underlying the pathophysiological processes observed with aging is pivotal to target those patients and their therapeutic needs properly. This review aims to investigate and to dissect the main pathways leading to the aging cardiomyopathy, helping to understand the relationship from bench to bedside of the clinical phenotype...
July 17, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30024399/successful-cryoablation-of-incessant-fast-slow-atypical-atrioventricular-nodal-reentrant-tachycardia-in-a-child-with-tachycardia-induced-cardiomyopathy
#4
Yakup Ergül, Ahmet İrdem, Osman Esen, Alper Güzeltaş
A 15-year-old female patient presented at the clinic with heart failure (HF). A 12-lead electrocardiogram showed a heart rate of 170 bpm; negative P waves in leads DII, DIII, aVF; and long RP tachycardia (LRPT). Echocardiography demonstrated a shortening fraction (SF) of 20%. An electrophysiology study during tachycardia revealed an atrial-His time of 52 milliseconds and a His-atrial interval of 295 milliseconds. During ventricular entrainment, the postpacing interval-tachycardia cycle length was measured at 225 milliseconds...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/30024279/improving-heart-failure-readmission-costs-and-outcomes-with-a-hospital-to-home-readmission-intervention-program
#5
Kenneth Bilchick, Travis Moss, Timothy Welch, Wayne Levy, George Stukenborg, Bryan T Lawlor, Juanita Reigle, S Craig Thomas, Carolyn Brady, James D Bergin, Jamie L W Kennedy, Mohammed Abuannadi, Kenneth Scully, Sula Mazimba
A retrospective cohort study was performed of the Hospital-to-Home (H2H) program, a rapid clinic follow-up program for patients with recent heart failure (HF) admissions at the University of Virginia Health System. There were 6761 hospitalizations among 4685 patients (age 67.5 ± 14.2 years, 43.9% female), and 759 had H2H follow-up. Thirty day mortality after the initial HF hospitalization was lower in H2H patients (1.84% vs 3.13%; P = .049), and this difference remained significant after adjustment in a multivariable logistic regression model (odds ratio = 0...
July 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/30023084/the-burden-of-heart-failure-in-the-general-population-a-clearer-and-more-concerning-picture
#6
EDITORIAL
Thomas G von Lueder, Stefan Agewall
No abstract text is available yet for this article.
June 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30022771/prognostic-value-of-a-simple-echocardiographic-parameter-the-right-ventricular-systolic-to-diastolic-duration-ratio-in-patients-with-advanced-heart-failure-with-non-ischemic-dilated-cardiomyopathy
#7
Boqing Xu, Takayuki Kawata, Masao Daimon, Koichi Kimura, Tomoko Nakao, Seitetz C Lee, Megumi Hirokawa, Aya Yoshinaga, Masafumi Watanabe, Yutaka Yatomi, Issei Komuro
The prognostic value of the right ventricular (RV) systolic to diastolic duration ratio (S/D ratio) in patients with advanced heart failure is not clear.We enrolled 45 patients with DCM (40 ± 13 years, 33 male) who were admitted to our hospital for evaluation or treatment of heart failure. The RV systolic and diastolic durations were measured using continuous Doppler imaging of tricuspid regurgitation, and the RV S/D ratio was calculated. Cardiac events were defined as cardiac death or left ventricular assist device implantation within the first year...
July 18, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30022769/correlates-and-prognostic-values-of-appearance-of-l-wave-in-heart-failure-patients-with-preserved-vs-reduced-ejection-fraction
#8
Kumiko Masai, Toshiaki Mano, Akiko Goda, Masataka Sugahara, Aika Daimon, Masanori Asakura, Masaharu Ishihara, Tohru Masuyama
BACKGROUND: Mid-diastolic mitral forward flow (L wave) is occasionally detected in heart failure (HF), but its correlates and prognostic value are still unknown, particularly in light of the type of HF, that is, HF with preserved or with reduced ejection fraction (HFpEF, HFrEF).Methods and Results:Of 151 patients with HF, L wave was observed in 23 of 82 HFrEF patients and in 25 of 69 HFpEF patients. Mitral early diastolic velocity (E), the ratio of E to mitral annulus velocity, and left atrial volume index were greater in the patients with L wave than in those without L wave in both subsets...
July 19, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30022366/resynchronization-therapy-for-patients-with-congenital-heart-disease-are-we-ready-for-prime-time
#9
REVIEW
Scott Anjewierden, Peter F Aziz
PURPOSE OF REVIEW: This review aims to summarize and provide an update of evidence for cardiac resynchronization therapy (CRT) in pediatric and adult congenital heart disease (CHD). RECENT FINDINGS: CRT is a valuable tool in the treatment of heart failure in the setting of CHD. Current evidence points toward the ability of this therapy to increase hemodynamic parameters and reduce heart failure-related symptoms. Within the CHD population, patients with systemic left ventricles appear to benefit the most from CRT...
July 18, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/30022358/non-sarcomeric-causes-of-heart-failure-a-sydney-heart-bank-perspective
#10
REVIEW
C G Dos Remedios, A Li, S Lal
No abstract text is available yet for this article.
July 18, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/30022355/thiamine-therapy-for-heart-failure-a-promise-or-fiction
#11
EDITORIAL
Ajoe John Kattoor, Akshay Goel, Jawahar L Mehta
No abstract text is available yet for this article.
July 18, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/30022113/pregnancy-outcomes-reported-during-the-13-year-treat-registry-a-descriptive-report
#12
Gary R Lichtenstein, Brian G Feagan, Uma Mahadevan, Bruce A Salzberg, Wayne Langholff, G James Morgan, Michael Safdi, Riikka Nissinen, François Taillard, William J Sandborn, Russell D Cohen
OBJECTIVES: We described pregnancy outcomes in Crohn's disease (CD) patients enrolled in the TREAT Registry who received infliximab before, or during pregnancy and those not treated with infliximab or any biologic agent. METHODS: In the TREAT Registry (1999-2012), pregnancy outcomes were analyzed from maternal and paternal patients exposed to infliximab ≤365 days (gestational exposure), >365 days (pre-gestational exposure) of pregnancy outcome or without infliximab exposure (non-biologic exposed)...
July 19, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30022092/association-between-height-and-actinic-keratosis-a-nationwide-population-based-study-in-south-korea
#13
Young Bok Lee, Ji Hyun Lee, Min Ji Kang, Jin-Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
The association between actinic keratosis (AK) and anthropometric measures has not been investigated. This study aims to evaluate the associations between anthropometric measures and the incidence of AK in South Korea. We analyzed clinical data from individuals aged over 20 years who received a health examination arranged by the national insurance program between 2005 and 2008. Newly diagnosed AK was identified using claims data from baseline to the date of diagnosis or until December 31, 2015. The incidence of AK was highest among the elderly (aged over 60 years) and showed a male bias...
July 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30021848/ampk-blunts-chronic-heart-failure-by-inhibiting-autophagy
#14
Yanhui Li, Yan Wang, Man Zou, Cong Chen, Yili Chen, Ruicong Xue, Yugang Dong, Chen Liu
AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, has been shown to exert a protective effect against cardiac hypertrophy and heart failure. Our previous reports have demonstrated that AMPK can inhibit cardiac hypertrophy and block the development of heart failure by promoting autophagy. However, other investigators have demonstrated that overactive and dysregulated autophagy may also contribute to the onset and exacerbation of heart failure. Thus, a major goal of the present investigation is to explore how AMPK regulates autophagy in heart failure...
August 31, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30021090/evaluation-of-medicare-s-bundled-payments-initiative-for-medical-conditions
#15
Karen E Joynt Maddox, E John Orav, Jie Zheng, Arnold M Epstein
BACKGROUND: The Center for Medicare and Medicaid Innovation (CMMI) launched the Bundled Payments for Care Improvement (BPCI) initiative in 2013. A subsequent study showed that the initiative was associated with reductions in Medicare payments for total joint replacement, but little is known about the effect of BPCI on medical conditions. METHODS: We used Medicare claims from 2013 through 2015 to identify admissions for the five most commonly selected medical conditions in BPCI: congestive heart failure (CHF), pneumonia, chronic obstructive pulmonary disease (COPD), sepsis, and acute myocardial infarction (AMI)...
July 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30020445/causes-of-death-in-japanese-patients-with-atrial-fibrillation-the-fushimi-af-registry
#16
Yoshimori An, Hisashi Ogawa, Yugo Yamashita, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Gregory Y H Lip, Masaharu Akao
Aims: To investigate the causes of death and the associated clinical factors in patients with atrial fibrillation (AF) in the contemporary clinical practice. Methods and Results: The Fushimi AF Registry is a community-based prospective survey of AF patients since March 2011 in Fushimi-ku, Kyoto. We investigated causes of death and the clinical indicators of cardiovascular (CV) and non-CV death in 4,045 patients with available follow-up data by the end of November 2016...
July 18, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/30020440/primary-prevention-implantable-cardioverter-defibrillator-and-opportunities-for-sudden-cardiac-death-risk-assessment-in-non-ischaemic-cardiomyopathy
#17
Rajeev K Pathak, Prashanthan Sanders, Rajat Deo
Sudden cardiac death (SCD) accounts for approximately one-third of all deaths among patients with non-ischaemic cardiomyopathy (NICM). Implantable cardioverter-defibrillator (ICD) therapy has been the primary intervention for managing individuals at high risk for SCD. However, individual ICD trials in the NICM population have failed to demonstrate a mortality benefit with prophylactic ICD implantation. Current guidelines recommend ICD implantation in NICM patients with symptomatic heart failure and a left ventricular ≤35% and are based on meta-analyses of multiple trials that span three decades and include the recent Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischaemic Heart Failure on Mortality (DANISH) trial...
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30020419/increased-resting-heart-rate-on-electrocardiogram-relative-to-in-office-pulse-rate-indicates-cardiac-overload-the-j-hop-study
#18
Yusuke Oba, Satoshi Hoshide, Tomoyuki Kabutoya, Kazuomi Kario
BACKGROUND: Heart rate (HR) assessed by electrocardiogram (ECG-HR) and pulse rate (PR) measured in a physician's office (office-PR) are taken with subjects in different body positions-i.e., supine vs. sitting. Although analysis of HR differences according to body position could provide new practical insights, there have been few studies on the subject. We herein investigated whether the difference between office-PR and ECG-HR (delta HR) was associated with brain natriuretic peptide (BNP) levels and left ventricular mass (LVM)...
July 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30020417/bezlotoxumab
#19
Stuart Johnson, Dale N Gerding
C. difficile infection (CDI) is mediated by actions of toxin A and toxin B. Fully human monoclonal antibodies directed against the binding domains of these toxins were developed. Despite pre-clinical studies suggesting efficacy for the anti-toxin A monoclonal, actoxumab, the anti-toxin B monoclonoal, bezolotoxumab, alone was shown to be effective in clinical trials. Intravenous infusion of bezlotoxumab at a 10 mg/kg dosage as adjunctive treatment reduced the risk of recurrent CDI over placebo for adult patients at increased risk for CDI recurrence in two large randomized, double-blind trials...
July 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30020325/prognostic-impact-of-iron-metabolism-changes-in-patients-with-acute-coronary-syndrome
#20
Tatiana Duarte, Sara Gonçalves, Catarina Sá, Rita Rodrigues, Rita Marinheiro, Marta Fonseca, Filipe Seixo, Rui Caria
BACKGROUND: Iron metabolism disorders have been associated with an increased risk of cardiovascular events. However, the prognostic impact on patients (pts) with acute coronary syndrome (ACS) has yet to be clarified. OBJECTIVE: To determine the prognostic value of serum iron and ferritin levels in pts with ACS in the short and long-term. METHODS: Consecutive pts admitted to a coronary care unit with a diagnosis of ACS, for a period of 2 years, were evaluated...
July 16, 2018: Arquivos Brasileiros de Cardiologia
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