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critical illness myopathy

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https://www.readbyqxmd.com/read/28042370/review-of-critical-illness-myopathy-and-neuropathy
#1
Starane Shepherd, Ayush Batra, David P Lerner
Critical illness myopathy (CIM) and neuropathy are underdiagnosed conditions within the intensive care setting and contribute to prolonged mechanical ventilation and ventilator wean failure and ultimately lead to significant morbidity and mortality. These conditions are often further subdivided into CIM, critical illness polyneuropathy (CIP), or the combination-critical illness polyneuromyopathy (CIPNM). In this review, we discuss the epidemiology and pathophysiology of CIM, CIP, and CIPNM, along with diagnostic considerations such as detailed clinical examination, electrophysiological studies, and histopathological review of muscle biopsy specimens...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/27997684/childhood-onset-multifocal-pyomyositis-presenting-as-critical-illness-myopathy
#2
Alberto M Cappellari, Irene M Borzani
No abstract text is available yet for this article.
December 20, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27997678/tetraparetic-critically-ill-patients-show-electrophysiological-signs-of-myopathy
#3
Clarissa Crone
INTRODUCTION: Critically ill patients often develop tetraparesis. It has been debated whether this is caused by neuropathy, myopathy, or both. The aim was to determine the incidence of myopathy and neuropathy in weak patients in the intensive care unit by performing several electrophysiological examinations, including quantitative EMG. METHODS: Forty-nine patients referred for electrophysiological examination because of suspected critical illness-related weakness underwent electromyography (EMG), nerve conduction studies, and direct muscle stimulation...
December 20, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27989427/exome-sequencing-is-a-valuable-approach-in-critically-ill-patients-with-suspected-monogenic-disease-diagnosis-of-x-linked-centronuclear-myopathy-in-preterm-twins
#4
Jessika Johannsen, Maja Hempel, Thilo Diehl, Tobias B Haack, Jonas Denecke
No abstract text is available yet for this article.
November 22, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27979685/nervous-system-abnormalities-and-legionnaire-s-disease
#5
REVIEW
John J Halperin
Although patients with Legionnaire's disease frequently develop alterations of consciousness, this is no more frequent than in patients hospitalized with other, equally severe forms of bacterial pneumonia. Legionella meningitis occurs rarely, if ever. Patients with Legionnaire's are susceptible to critical illness polyneuropathy/myopathy, as are other critically ill patients. Legionnaire's patients may develop MRI hyperdensities in the splenium of the corpus callosum, as may other patients with severe infections...
December 12, 2016: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/27922495/toxic-and-endocrine-myopathies
#6
Hans D Katzberg, Charles D Kassardjian
PURPOSE OF REVIEW: This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies. RECENT FINDINGS: Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasis, which can cause a myosin-loss myopathy...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27881152/fitness-and-mobility-training-in-patients-with-intensive-care-unit-acquired-muscle-weakness-fitonicu-study-protocol-for-a-randomised-controlled-trial
#7
Jan Mehrholz, Simone Thomas, Jane H Burridge, André Schmidt, Bettina Scheffler, Ralph Schellin, Stefan Rückriem, Daniel Meißner, Katja Mehrholz, Wolfgang Sauter, Ulf Bodechtel, Bernhard Elsner
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP) are a common complication of critical illness. Both cause intensive-care-unit-acquired (ICU-acquired) muscle weakness (ICUAW) which increases morbidity and delays rehabilitation and recovery of activities of daily living such as walking ability. Focused physical rehabilitation of people with ICUAW is, therefore, of great importance at both an individual and a societal level. A recent systematic Cochrane review found no randomised controlled trials (RCT), and thus no supporting evidence, for physical rehabilitation interventions for people with defined CIP and CIM to improve activities of daily living...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27513545/neuromuscular-blocking-agents-and-neuromuscular-dysfunction-acquired-in-critical-illness-a-systematic-review-and-meta-analysis
#8
David R Price, Mark E Mikkelsen, Craig A Umscheid, Ehrin J Armstrong
OBJECTIVE: The relationship between neuromuscular blocking agents and neuromuscular dysfunction acquired in critical illness remains unclear. We examined the association between neuromuscular blocking agents and ICU-acquired weakness, critical illness polyneuropathy, and critical illness myopathy. DATA SOURCES: PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, and bibliographies of included studies were searched from database inception until September 24, 2015...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27510990/impaired-ca-2-release-contributes-to-muscle-weakness-in-a-rat-model-of-critical-illness-myopathy
#9
Monica Llano-Diez, Arthur J Cheng, William Jonsson, Niklas Ivarsson, Håkan Westerblad, Vic Sun, Nicola Cacciani, Lars Larsson, Joseph Bruton
BACKGROUND: Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS: We used a unique ICU model where rats were deeply sedated, post-synaptically pharmacologically paralyzed, mechanically ventilated and closely monitored for up to ten days. Single intact fibers from the flexor digitorum brevis muscle were isolated and used to measure force and free myoplasmic [Ca(2+)] ([Ca(2+)]i) during tetanic contractions...
August 10, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27502507/critical-illness-polyneuropathy-and-myopathy-20%C3%A2-years-later-no-man-s-land-no-it-is-our-land
#10
Nicola Latronico
No abstract text is available yet for this article.
August 8, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27220357/physical-rehabilitation-interventions-for-adult-patients-during-critical-illness-an-overview-of-systematic-reviews
#11
Bronwen Connolly, Brenda O'Neill, Lisa Salisbury, Bronagh Blackwood
BACKGROUND: Physical rehabilitation interventions aim to ameliorate the effects of critical illness-associated muscle dysfunction in survivors. We conducted an overview of systematic reviews (SR) evaluating the effect of these interventions across the continuum of recovery. METHODS: Six electronic databases (Cochrane Library, CENTRAL, DARE, Medline, Embase, and Cinahl) were searched. Two review authors independently screened articles for eligibility and conducted data extraction and quality appraisal...
October 2016: Thorax
https://www.readbyqxmd.com/read/27063347/icu-acquired-weakness
#12
REVIEW
Sarah E Jolley, Aaron E Bunnell, Catherine L Hough
Survivorship after critical illness is an increasingly important health-care concern as ICU use continues to increase while ICU mortality is decreasing. Survivors of critical illness experience marked disability and impairments in physical and cognitive function that persist for years after their initial ICU stay. Newfound impairment is associated with increased health-care costs and use, reductions in health-related quality of life, and prolonged unemployment. Weakness, critical illness neuropathy and/or myopathy, and muscle atrophy are common in patients who are critically ill, with up to 80% of patients admitted to the ICU developing some form of neuromuscular dysfunction...
November 2016: Chest
https://www.readbyqxmd.com/read/27025938/recovery-and-outcomes-after-the-acute-respiratory-distress-syndrome-ards-in-patients-and-their-family-caregivers
#13
REVIEW
Margaret S Herridge, Marc Moss, Catherine L Hough, Ramona O Hopkins, Todd W Rice, O Joseph Bienvenu, Elie Azoulay
Outcomes after acute respiratory distress syndrome (ARDS) are similar to those of other survivors of critical illness and largely affect the nerve, muscle, and central nervous system but also include a constellation of varied physical devastations ranging from contractures and frozen joints to tooth loss and cosmesis. Compromised quality of life is related to a spectrum of impairment of physical, social, emotional, and neurocognitive function and to a much lesser extent discrete pulmonary disability. Intensive care unit-acquired weakness (ICUAW) is ubiquitous and includes contributions from both critical illness polyneuropathy and myopathy, and recovery from these lesions may be incomplete at 5 years after ICU discharge...
May 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26990577/mechano-signalling-pathways-in-an-experimental-intensive-critical-illness-myopathy-model
#14
Rebeca Corpeno Kalamgi, Heba Salah, Stefano Gastaldello, Vicente Martinez-Redondo, Jorge L Ruas, Wen Fury, Yu Bai, Jesper Gromada, Roberta Sartori, Denis C Guttridge, Marco Sandri, Lars Larsson
KEY POINTS: Using an experimental rat intensive care unit (ICU) model, not limited by early mortality, we have previously shown that passive mechanical loading attenuates the loss of muscle mass and force-generation capacity associated with the ICU intervention. Mitochondrial dynamics have recently been shown to play a more important role in muscle atrophy than previously recognized. In this study we demonstrate that mitochondrial dynamics, as well as mitophagy, is affected by mechanosensing at the transcriptional level, and muscle changes induced by unloading are counteracted by passive mechanical loading...
August 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26869939/mechanical-signaling-in-the-pathophysiology-of-critical-illness-myopathy
#15
REVIEW
Rebeca C Kalamgi, Lars Larsson
The complete loss of mechanical stimuli of skeletal muscles, i.e., the loss of external strain, related to weight bearing, and internal strain, related to the contraction of muscle cells, is uniquely observed in pharmacologically paralyzed or deeply sedated mechanically ventilated intensive care unit (ICU) patients. The preferential loss of myosin and myosin associated proteins in limb and trunk muscles is a significant characteristic of critical illness myopathy (CIM) which separates CIM from other types of acquired muscle weaknesses in ICU patients...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26842898/-critical-illness-polyneuropathy-and-myopathy-as-neurological-complications-of-sepsis
#16
REVIEW
R Kollmar
Intensive care unit acquired weakness (ICUAW) is a frequent and severe complication of intensive care management. Within ICUAW critical illness polyneuropathy (CIP) and myopathy (CIM) can be differentiated. The major symptom of ICUAW is progressive quadriparesis, which makes weaning from the respirator more difficult, can appear early after admission to an ICU and can often be detected several months after discharge from the ICU. The pathophysiology of ICUAW is multifactorial and complex. Potential therapeutic approaches are the early and sufficient therapy of mulitorgan dysfunction, optimal control of glucose levels as well as early and intensive physiotherapy...
March 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/26570895/1234-a-curious-case-of-severe-copper-deficiency-and-critical-illness-myopathy
#17
Cynthia Tsai, Mary Reed, Sarah Dayton, Joseph Smith
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26570174/513-critical-illness-polyneuropathy-and-myopathy-in-the-picu
#18
Shauna Burkholder, Lee Burkholder, Matthew Prowse, Joe Watt, Ari Joffe
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26492063/icu-acquired-weakness-is-associated-with-differences-in-clinical-outcomes-in-critically-ill-children
#19
Aida Field-Ridley, Madan Dharmar, David Steinhorn, Craig McDonald, James P Marcin
OBJECTIVE: ICU-acquired weakness, comprised critical illness myopathy and critical illness neuropathy, occurs in a significant proportion of critically ill adults and is associated with high morbidity and mortality. Little is known about ICU-acquired weakness among critically ill children. We investigated the incidence of ICU-acquired weakness among PICUs participating in the Virtual PICU Systems database. We also sought to identify associated risk factors for ICU-acquired weakness and evaluate the hypothesis that ICU-acquired weakness is associated with poor clinical outcomes...
January 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26311145/optimizing-testing-methods-and-collection-of-reference-data-for-differentiating-critical-illness-polyneuropathy-from-critical-illness-myopathies
#20
Humberto Gonzalez Marrero, Erik V Stålberg
INTRODUCTION: In severe acute quadriplegic myopathy in intensive care unit (ICU) patients, muscle fibers are electrically inexcitable; in critical illness polyneuropathy, the excitability remains normal. Conventional electrodiagnostic methods do not provide the means to adequately differentiate between them. In this study we aimed to further optimize the methodology for the study of critically ill ICU patients and to create a reference database in healthy controls. METHODS: Different electrophysiologic protocols were tested to find sufficiently robust and reproducible techniques for clinical diagnostic applications...
April 2016: Muscle & Nerve
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