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"Over diagnosis" OR overdiagnosis

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https://www.readbyqxmd.com/read/28818742/citrus-cervical-cancer-screening-trial-by-randomization-of-hpv-testing-intervention-for-upcoming-screening-design-methods-and-baseline-data-of-18-471-women
#1
Tohru Morisada, Katsuhiro Teramoto, Hirokuni Takano, Ikuko Sakamoto, Hiroshi Nishio, Takashi Iwata, Akihiko Hashi, Ryohei Katoh, Aikou Okamoto, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
BACKGROUND: To assess the efficacy of screening with concurrent liquid-based cytology and human papillomavirus (HPV) testing for primary cervical cancer screening, we initiated a randomized trial entitled CervIcal cancer screening Trial by Randomization of HPV testing intervention for Upcoming Screening (CITRUS). METHODS: Between June 2013 and March 2015, women aged 30-64 years of age who participated in a regular cervical cancer screening program (every 2 years) were invited to enrollment of our study...
August 14, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28814560/overdiagnosis-ethics-and-trolley-problems-why-factors-other-than-outcomes-matter-an-essay-by-stacy-carter
#2
Stacy M Carter
No abstract text is available yet for this article.
August 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28814557/when-technology-creates-uncertainty-pulse-oximetry-and-overdiagnosis-of-hypoxaemia-in-bronchiolitis
#3
Ricardo A Quinonez, Eric R Coon, Alan R Schroeder, Virginia A Moyer
No abstract text is available yet for this article.
August 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28814436/mapping-the-drivers-of-overdiagnosis-to-potential-solutions
#4
Thanya Pathirana, Justin Clark, Ray Moynihan
No abstract text is available yet for this article.
August 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28813112/what-do-cochrane-systematic-reviews-say-about-the-clinical-effectiveness-of-screening-and-diagnostic-tests-for-cancer
#5
André Tito Pereira Bueno, Vladimir Lisboa Capelasso, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca, Tiago Biachi de Castria, Daniela Vianna Pachito, Rachel Riera
CONTEXT AND OBJECTIVE: The purpose of screening tests for cancer is to detect it at an early stage in order to increase the chances of treatment. However, their unrestrained use may lead to unnecessary examinations, overdiagnosis and higher costs. It is thus necessary to evaluate their clinical effects in terms of benefits and harm. DESIGN AND SETTING: Review of Cochrane systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28811244/comparison-of-the-clinical-course-of-clostridium-difficile-infection-in-gdh-positive-toxin-negative-patients-diagnosed-by-pcr-to-those-with-a-positive-toxin-test
#6
Julia Origüen, Laura Corbella, María Ángeles Orellana, Mario Fernández-Ruiz, Francisco López-Medrano, Rafael San Juan, Manuel Lizasoain, Tamara Ruiz-Merlo, Alejandra Morales-Cartagena, Guillermo Maestro, Patricia Parra, Jennifer Villa, Rafael Delgado, José María Aguado
OBJECTIVES: To evaluate the potential role of PCR-based assays in the overdiagnosis of Clostridium difficile infection (CDI) by using a validated diagnostic algorithm in daily clinical practice. METHODS: We performed a retrospective cohort study evaluating all C. difficile-positive stool samples identified at our institution during a 12-month period, to compare outcomes and recurrence rate between patients with a positive enzyme-immunoassay (EIA) for both glutamate dehydrogenase (GDH) and toxin A/B ("toxin-positive group"), with those with GDH-positive, toxin-negative samples in which the diagnosis was made by a positive PCR-based assay ("toxin-/PCR+ group")...
August 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28807924/thyroid-cancer-incidence-in-canada-a-national-cancer-registry-analysis
#7
Dawnelle Topstad, James A Dickinson
BACKGROUND: Thyroid cancer incidence rates are increasing in many developed countries while mortality rates remain stable. International evidence shows that the increase in incidence rates is mostly caused by overdiagnosis of small papillary cancers. We sought to describe how thyroid cancer incidence has changed and how it varies between provinces in Canada. METHODS: Data were obtained from the National Cancer Incidence Reporting System, causes of death tables and the Canadian Cancer Registry using the 1991 census population structure...
August 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28799687/upfront-immunohistochemistry-improves-specificity-of-helicobacter-pylori-diagnosis-a-french-pathology-laboratory-point-of-view
#8
Florent Ginestet, Briac Guibourg, Laurent Doucet, Jérémie Théreaux, Michel Robaszkiewicz, Pascale Marcorelles, Arnaud Uguen
BACKGROUND: There is no consensus about the histopathologic methods to detect Helicobacter pylori in gastric biopsies to date. We aimed to question about the value of upfront anti-H. pylori immunohistochemistry in this field. MATERIAL AND METHODS: We led a retrospective study about the rate of H. pylori-positive gastric biopsies before and after the implementation of upfront immunohistochemistry, the inter-rater and intermethods agreements in H. pylori identification about Hematoxylin-Eosin Saffron (HES), Giemsa, and immunohistochemistry stains and the histopathologic features associated with low amounts of H...
August 11, 2017: Helicobacter
https://www.readbyqxmd.com/read/28796922/long-non-coding-rnas-and-prostate-cancer
#9
REVIEW
Aya Misawa, Ken-Ichi Takayama, Satoshi Inoue
Long non-coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins whose aberrant expression has been documented in various types of cancer, including prostate cancer. The lack of appropriate sensitive and specific biomarkers for prostate cancer has led to over-diagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. This review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis...
August 10, 2017: Cancer Science
https://www.readbyqxmd.com/read/28783215/sensitization-to-dust-mite-defines-different-phenotypes-of-asthma-a-multicenter-study
#10
Silvia Ruggieri, Gaspare Drago, Valeria Longo, Paolo Colombo, Martin Balzan, David Bilocca, Christopher Zammit, Stephen Montefort, Gianluca Scaccianoce, Giuseppina Cuttitta, Giovanni Viegi, Fabio Cibella
BACKGROUND: Indoor allergens are risk factors for asthma: thus, the characterization of indoor air quality is important for studying environment-health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization and indoor allergen concentration. METHODS: One hundred thirty two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires...
August 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28780499/how-to-feed-a-baby-recovering-from-necrotising-enterocolitis-when-maternal-milk-is-not-available
#11
REVIEW
Nicholas D Embleton, Stefan P Zalewski
Necrotising enterocolitis (NEC) is a devastating disease with significant mortality and serious adverse outcomes in at least 50% including short gut and poor neurodevelopment. Research and management are complicated by a lack of robust clinical markers, and without histological confirmation, there is a risk of both underdiagnosis and overdiagnosis. Interunit variations in the thresholds for surgical referral, laparotomy and postmortem rates mean the actual incidence is difficult to determine, especially because the histological term 'NEC' is used in practice to describe a heterogeneous clinical syndrome...
August 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28768400/strategies-for-appropriate-patient-centered-care-to-decrease-the-nationwide-cost-of-cancers-in-korea
#12
Jong-Myon Bae
In terms of years of life lost to premature mortality, cancer imposes the highest burden in Korea. In order to reduce the burden of cancer, the Korean government has implemented cancer control programs aiming to reduce cancer incidence, to increase survival rates, and to decrease cancer mortality. However, these programs may paradoxically increase the cost burden. For examples, a cancer screening program for early detection could bring about over-diagnosis and over-treatment, and supplying medical services in a paternalistic manner could lead to defensive medicine or futile care...
July 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28765860/assessing-the-efficacy-of-cancer-screening
#13
Gemma Jacklyn, Katy Bell, Andrew Hayen
BACKGROUND: Population-based cancer screening has been established for several types of cancer in Australia and internationally. Screening may perform differently in practice from randomised controlled trials, which makes evaluating programs complex. MATERIALS AND METHODS: We discuss how to assess the evidence of benefits and harms of cancer screening, including the main biases that can mislead clinicians and policy makers (such as volunteer, lead-time, length-time and overdiagnosis bias)...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28765858/history-development-and-future-of-cancer-screening-in-australia
#14
Ian N Olver, David Roder
INTRODUCTION: The aim of screening an asymptomatic population for cancer is to achieve better health outcomes, particularly a population survival benefit. Australia has three population screening programs: the National Cervical Screening Program (NCSP), BreastScreen Australia and the National Bowel Cancer Screening Program (NBCSP). METHODS: We reviewed the history and development of the three programs. NCSP: Women have a Pap smear every 2 years from age 18-20, or 2 years after first becoming sexually active, until age 69...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28765855/what-is-overdiagnosis-and-why-should-we-take-it-seriously-in-cancer-screening
#15
Stacy M Carter, Alexandra Barratt
Overdiagnosis occurs in a population when conditions are diagnosed correctly but the diagnosis produces an unfavourable balance between benefits and harms. In cancer screening, overdiagnosed cancers are those that did not need to be found because they would not have produced symptoms or led to premature death. These overdiagnosed cancers can be distinguished from false positives, which occur when an initial screening test suggests that a person is at high risk but follow-up testing shows them to be at normal risk...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28764259/survey-of-diagnostic-criteria-for-fetal-distress-in-latin-american-and-african-countries-over-diagnosis-or-under-diagnosis
#16
Maria Paula Cateriano-Alberdi, Cecilia D Palacios-Revilla, Eddy R Segura
No abstract text is available yet for this article.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763304/chronic-inflammatory-demyelinating-polyneuropathy
#17
Richard A Lewis
PURPOSE OF REVIEW: As a syndrome with typical and atypical cases, chronic inflammatory demyelinating polyneuropathy (CIDP) has been a difficult disorder to diagnose and treat. The pathophysiologic basis for CIDP has not been established, contributing to the challenges in dealing with these patients. However, as one of only a handful of treatable peripheral neuropathies, there has been a tendency to diagnose CIDP to attempt a therapeutic intervention. We are also aware that there has also been overtreatment of some patients...
July 29, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28762545/epigenetic-risk-score-improves-prostate-cancer-risk-assessment
#18
Leander Van Neste, Jack Groskopf, William E Grizzle, George W Adams, Mark S DeGuenther, Peter N Kolettis, James E Bryant, Gary P Kearney, Michael C Kearney, Wim Van Criekinge, Sandra M Gaston
BACKGROUND: Early detection of aggressive prostate cancer (PCa) remains crucial for effective treatment of patients. However, PCa screening remains controversial due to a high rate of overdiagnosis and overtreatment. To better reconcile both objectives, more effective methods for assessing disease severity at the time of diagnosis are needed. METHODS: The relationship between DNA-methylation and high-grade PCa was examined in a cohort of 102 prospectively enrolled men who received standard 12-core prostate biopsies...
August 1, 2017: Prostate
https://www.readbyqxmd.com/read/28762124/a-randomized-trial-of-early-detection-of-clinically-significant-prostate-cancer-proscreen-study-design-and-rationale
#19
Anssi Auvinen, Antti Rannikko, Kimmo Taari, Paula Kujala, Tuomas Mirtti, Anu Kenttämies, Irina Rinta-Kiikka, Terho Lehtimäki, Niku Oksala, Kim Pettersson, Teuvo L Tammela
The current evidence of PSA-based prostate cancer screening shows a reduction in cause-specific mortality, but with substantial overdiagnosis. Recently, new developments in detection of clinically relevant prostate cancer include multiple kallikreins as biomarkers besides PSA, and multiparametric magnetic resonance imaging (mpMRI) for biopsy decision. They offer opportunities for improving the outcomes in screening, particularly reduction in overdiagnosis and higher specificity for potentially lethal cancer...
July 31, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28755627/the-importance-of-laboratory-re-evaluation-in-cases-of-suspected-child-abuse-a-case-report
#20
L Woydt, C König, M K Bernhard, P Nickel, J Dreßler, B Ondruschka
In order to accurately diagnose child abuse or neglect, a physician needs to be familiar with diseases and medical conditions that can simulate maltreatment. Unrecognized cases of abuse may lead to insufficient child protection, whereas, on the other hand, over-diagnosis could be the cause of various problems for the family and their potentially accused members. Regarding child abuse, numerous cases of false diagnoses with undetected causes of bleeding are described in the scientific literature, but, specifically concerning leukemia in childhood, only very few case reports exist...
July 24, 2017: Legal Medicine
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