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"Over diagnosis" OR overdiagnosis

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https://www.readbyqxmd.com/read/29149513/physicians-discuss-ramifications-of-studies-pointing-to-breast-cancer-overdiagnosis-new-research-under-way-attempts-to-better-define-who-should-be-screened-and-treated
#1
https://www.readbyqxmd.com/read/29145557/comparative-analysis-of-the-growth-pattern-of-thyroid-cancer-in-young-patients-screened-by-ultrasonography-in-japan-after-a-nuclear-accident-the-fukushima-health-management-survey
#2
Sanae Midorikawa, Akira Ohtsuru, Michio Murakami, Hideto Takahashi, Satoru Suzuki, Takashi Matsuzuka, Hiroki Shimura, Tetsuya Ohira, Shin-Ichi Suzuki, Seiji Yasumura, Shunichi Yamashita, Hitoshi Ohto, Koichi Tanigawa, Kenji Kamiya
Importance: Thyroid cancer generally grows at a very slow rate in adults, and overdiagnosis is a global issue. However, the detection of early-stage thyroid cancer by screening is not well described in young patients. To prevent overdiagnosis, it is essential to understand the natural course of thyroid cancer growth detection by ultrasonography screening in young patients. Objective: To evaluate the natural progression of thyroid cancer in young patients. Design, Setting, and Participants: An observational study evaluated changes in the diameter of malignant or suspected malignant thyroid tumors on 2 occasions...
November 16, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29141352/-overdiagnosis-in-mammography-screening-for-breast-cancer
#3
Y B Huang, L Yang, F J Song, K X Chen
Screening has been always considered as a double-edged sword. Cancer screening could save lives in some cases, however, in other cases, it might also turn people into overdiagnosis. Overdiagnosis is the diagnosis of cancer that will never cause symptoms or death during a patient's lifetime. Therefore, overdiagnosis might lead to unnecessary treatments and lifetime surveillance, and then increase economic burden and psychological burden. In this review, we focus on how to correctly evaluate the overdiagnosis rate, and how to avoid or reduce the harms caused by overdiagnosis in the future according to the reasons associated with overdiagnosis...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29132673/diagnosis-of-food-allergy
#4
REVIEW
Malika Gupta, Amanda Cox, Anna Nowak-Węgrzyn, Julie Wang
Food allergy diagnosis remains challenging. Most standard methods are unable to differentiate sensitization from clinical allergy. Recognizing food allergy is of utmost importance to prevent life-threatening reactions. On the other hand, faulty interpretation of tests leads to overdiagnosis and unnecessary food avoidances. Highly predictive models have been established for major food allergens based on skin prick testing and food-specific immunoglobulin E but are lacking for most other foods. Although many newer diagnostic techniques are improving the accuracy of food allergy diagnostics, an oral food challenge remains the only definitive method of confirming a food allergy...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29127760/preoperative-breast-mri-examination-for-all-patients-with-histologically-proven-breast-cancer-a-concept-for-a-prospective-multicenter-trial
#5
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29117354/editorial-challenges-in-quantifying-overdiagnosis
#6
Stuart G Baker, Philip C Prorok, Barnett S Kramer
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29117353/quantifying-overdiagnosis-in-cancer-screening-a-systematic-review-to-evaluate-the-methodology
#7
Theodora M Ripping, Kevin Ten Haaf, André L M Verbeek, Nicolien T van Ravesteyn, Mireille J M Broeders
Background: Overdiagnosis is the main harm of cancer screening programs but is difficult to quantify. This review aims to evaluate existing approaches to estimate the magnitude of overdiagnosis in cancer screening in order to gain insight into the strengths and limitations of these approaches and to provide researchers with guidance to obtain reliable estimates of overdiagnosis in cancer screening. Methods: A systematic review was done of primary research studies in PubMed that were published before January 1, 2016, and quantified overdiagnosis in breast cancer screening...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29112014/hpv-e6-e7-mrna-in-situ-hybridization-in-the-diagnosis-of-cervical-low-grade-squamous-intraepithelial-lesions-lsil
#8
Anne M Mills, Joseph D Coppock, Brian C Willis, Mark H Stoler
Cervical low-grade squamous intraepithelial lesions (LSIL) (aka cervical intraepithelial neoplasia, grade 1 [CIN1]) can present considerable diagnostic challenges and are associated with poor interobserver reproducibility and overdiagnosis. Furthermore, ancillary studies such as p16 immunohistochemistry have shown little utility in resolving the LSIL versus negative/reactive differential. Human papillomavirus (HPV) RNA in situ hybridization (ISH) has shown promise as a diagnostic aid in this setting, but has not been studied in a large case series...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29106648/validation-of-echocardiographic-criteria-for-the-clinical-diagnosis-of-heart-failure-in-chronic-kidney-disease
#9
Kathrin Untersteller, Sarah Seiler-Mußler, Francesca Mallamaci, Danilo Fliser, Gérard M London, Carmine Zoccali, Gunnar H Heine
Background: The Acute Dialysis Quality Initiative (ADQI) XI Workgroup has suggested defining heart failure (HF) in patients with end-stage renal disease by the presence of at least one out of eight predefined echocardiographic criteria. Given the high prevalence of echocardiographic alterations in chronic kidney disease (CKD) patients, we hypothesized that application of echocardiographic ADQI criteria will result in overdiagnosis of HF, without providing substantial prognostic information...
July 5, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29103360/modelling-breast-cancer-tumour-growth-for-a-stable-disease-population
#10
Gabriel Isheden, Keith Humphreys
Statistical models of breast cancer tumour progression have been used to further our knowledge of the natural history of breast cancer, to evaluate mammography screening in terms of mortality, to estimate overdiagnosis, and to estimate the impact of lead-time bias when comparing survival times between screen detected cancers and cancers found outside of screening programs. Multi-state Markov models have been widely used, but several research groups have proposed other modelling frameworks based on specifying an underlying biological continuous tumour growth process...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29102484/repeated-implantation-failure-at-the-crossroad-between-statistics-clinics-and-over-diagnosis
#11
Edgardo Somigliana, Paola Vigano, Andrea Busnelli, Alessio Paffoni, Walter Vegetti, Paolo Vercellini
The most common definition of repeated implantation failure (RIF) is the failure to obtain a clinical pregnancy after three completed IVF cycles. This definition, however, may lead to misuse of the diagnosis. To disentangle this, we set up a mathematical model based on the following main assumptions: rate of success of IVF constant and set at 30%; and RIF postulated to be a dichotomous condition (yes or no) with a prevalence of 10%. On this basis, the expected cumulative chance of pregnancy after three and six cycles was 59% and 79%, respectively...
October 12, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29100363/alterations-in-expressed-prostate-secretion-urine-psa-n-glycosylation-discriminate-prostate-cancer-from-benign-prostate-hyperplasia
#12
Gaozhen Jia, Zhenyang Dong, Chenxia Sun, Fuping Wen, Haifeng Wang, Huaizu Guo, Xu Gao, Chuanliang Xu, Chuanliang Xu, Chenghua Yang, Yinghao Sun
The prostate specific antigen (PSA) test is widely used for early diagnosis of prostate cancer (PCa). However, its limited sensitivity has led to over-diagnosis and over-treatment of PCa. Glycosylation alteration is a common phenomenon in cancer development. Different PSA glycan subforms have been proposed as diagnostic markers to better differentiate PCa from benign prostate hyperplasia (BPH). In this study, we purified PSA from expressed prostate secretions (EPS)-urine samples from 32 BPH and 30 PCa patients and provided detailed PSA glycan profiles in Chinese population...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098421/what-is-the-accuracy-of-frozen-section-in-the-diagnosis-of-mucinous-ovarian-tumours-a-9-year-review-of-performance-in-a-greek-tertiary-referral-centre
#13
Anastasios Tranoulis, Nikolaos Thomakos, Maria Sotiropoulou, Alexandros Rodolakis
PURPOSE: This retrospective study aimed to evaluate the diagnostic accuracy of the intra-operative frozen sections (FS) of mucinous ovarian tumours (mOT). METHODS: Between 2007 and 2015, a total of 105 mucinous ovarian samples were collected during laparotomy. The intra-operative FS accuracy was evaluated and potential factors correlated with increased inaccuracy assessed using both univariate and multivariate analysis. RESULTS: The overall FS accuracy was 82...
November 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29097686/proof-of-concept-raman-spectroscopy-study-aimed-to-differentiate-thyroid-follicular-patterned-lesions
#14
Julietta V Rau, Marco Fosca, Valerio Graziani, Chiara Taffon, Massimiliano Rocchia, Marco Caricato, Paolo Pozzilli, Andrea Onetti Muda, Anna Crescenzi
Inter-observer variability and cancer over-diagnosis are emerging clinical problems, especially for follicular patterned thyroid lesions. This challenge strongly calls for a new clinical tool to reliably identify neoplastic lesions and to improve the efficiency of differentiation between benign and malignant neoplasms, especially considering the increased diagnosis of small carcinomas and the growing number of thyroid nodules. In this study, we employed a Raman spectroscopy (RS) microscope to investigate frozen thyroid tissues from fourteen patients with thyroid nodules...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096890/breast-cancer-epidemiology-prevention-and-screening
#15
Stella Winters, Charmaine Martin, Daniel Murphy, Navkiran K Shokar
Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. This pattern is likely to be due to changing risk factor profiles and differences in access to breast cancer early detection and treatment. Risk factors for breast cancer include increasing age, race, menarche history, breast characteristics, reproductive patterns, hormone use, alcohol use, tobacco use, diet, physical activity, and body habitus...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29095457/attomolar-detection-of-extracellular-micrornas-released-from-living-prostate-cancer-cells-by-a-plasmonic-nanowire-interstice-sensor
#16
Siyeong Yang, Hongki Kim, Kyung Jin Lee, Seul Gee Hwang, Eun-Kyung Lim, Juyeon Jung, Tae Jae Lee, Hee-Sung Park, Taejoon Kang, Bongsoo Kim
Prostate cancer (PC) is the second leading cause of cancer death for men worldwide. The serum prostate-specific antigen level test has been widely used to screen for PC. This method, however, exhibits a high false-positive rate, leading to over-diagnosis and over-treatment of PC patients. Extracellular microRNAs (miRNAs) recently provided valuable information including the site and the status of the cancers and thus emerged as new biomarkers for several cancers. Among them, miR141 and miR375 are the most pronounced biomarkers for the diagnosis of high-risk PC...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29091010/current-issues-in-the-overdiagnosis-and-overtreatment-of-breast-cancer
#17
Debra L Monticciolo, Mark A Helvie, R Edward Hendrick
OBJECTIVE: The discovery of breast cancer at earlier stages with screening brings the risk that some cancers will be overdiagnosed or overtreated. Reasonable estimates show the overdiagnosis rate due to screening mammography to be low, 1-10%. CONCLUSION: Overdiagnosis should not be used as a reason to delay the onset or decrease the frequency of screening, because neither strategy will decrease overdiagnosis. Improvements in personalized treatment will diminish the morbidity of treatment and, therefore, the significance of overdiagnosis...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29080559/self-diagnosis-of-malaria-by-travellers-a-cohort-study-on-the-use-of-malaria-rapid-diagnostic-tests-provided-by-a-swiss-travel-clinic
#18
Delphine Berthod, Jacynthe Rochat, Rachel Voumard, Laurence Rochat, Blaise Genton, Valérie D'Acremont
BACKGROUND: The WHO recommends that all suspect malaria cases be tested before receiving treatment. Rapid diagnostic tests (RDT) for malaria can be performed reliably by community health workers with no formal medical background and thus, RDTs could also be provided to travellers for self-diagnosis during visits to endemic regions. METHODS: RDTs were proposed during pre-travel consultations to pre-defined categories of travellers. A training run on their own blood was performed and, if carried out correctly, the traveller was given a written procedure on how to perform the test and act on its result...
October 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29075901/endoscopic-diagnosis-of-hiatus-hernia-under-deep-inspiration-is-not-consistent-with-esophageal-manometric-diagnosis
#19
Yuriko Hanada, Shintaro Hoshino, Yoshimasa Hoshikawa, Nana Takenouchi, Mariko Umezawa, Noriyuki Kawami, Katsuhiko Iwakiri
BACKGROUND: To investigate the relationship between endoscopic and esophageal manometric hiatus hernia (HH). METHODS: Forty-six gastroesophageal reflux disease patients with endoscopic HH under maintenance therapy were recruited. Endoscopy was performed on all patients in a fully conscious state. Endoscopic HH was defined as apparent separation greater than 1 cm of the lower margin of the esophageal palisade vessels and the diaphragm hiatus on endoscopy under deep inspiration...
October 26, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29072500/poor-sleep-has-negative-implications-for-children-with-and-without-adhd-but-in-different-ways
#20
Frances Le Cornu Knight, Dagmara Dimitriou
BACKGROUND: Sleep problems are commonly reported in attention deficit hyperactivity disorder (ADHD), and are also a familiar characteristic of typical development (TD). We sought to elucidate the relationship between sleep, ADHD trait behaviors, and cognitive inattention, and how it manifests between ADHD and TD children. PARTICIPANTS: Eighteen children diagnosed with ADHD and 20 age-matched TD controls aged 5 to 11 years old participated in the study. METHODS: Sleep profiles were assessed using Children's Sleep Habits Questionnaire and actigraphy measures...
October 26, 2017: Behavioral Sleep Medicine
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