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"Over diagnosis" OR overdiagnosis

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https://www.readbyqxmd.com/read/27931047/effect-of-population-breast-screening-on-breast-cancer-mortality-up-to-2005-in-england-and-wales-an-individual-level-cohort-study
#1
Louise E Johns, Derek A Coleman, Anthony J Swerdlow, Susan M Moss
BACKGROUND: Population breast screening has been implemented in the UK for over 25 years, but the size of benefit attributable to such programmes remains controversial. We have conducted the first individual-based cohort evaluation of population breast screening in the UK, to estimate the impact of the NHS breast screening programme (NHSBSP) on breast cancer mortality. METHODS: We followed 988 090 women aged 49-64 years in 1991 resident in England and Wales, who because of the staggered implementation of the NHSBSP, included both invited subjects and an uninvited control group...
December 8, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27929558/overdiagnosis-norwegian-general-practitioners-show-the-way
#2
Gisle Roksund, John Brodersen, Georg Espolin Johnson, Stefán Hjörleifsson, Morten Laudal, Elisabeth Swensen
No abstract text is available yet for this article.
December 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/27929212/top-poems-of-2015-consistent-with-the-principles-of-the-choosing-wisely-campaign
#3
Roland Grad, Mark H Ebell
The authors applied a novel method to identify recent clinical studies that showed results consistent with the principles of the Choosing Wisely campaign. The method, based on crowdsourcing studies known as POEMs (patientoriented evidence that matters), involved analyzing POEM ratings submitted by physician members of the Canadian Medical Association in the context of their continuing medical education. In the 251 unique POEMs delivered to these physicians in 2015, an average of 1,284 physician ratings were received per POEM...
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27922976/intraoperative-frozen-section-of-ovarian-tumors-a-6-year-review-of-performance-and-potential-pitfalls-in-an-australian-tertiary-referral-center
#4
Rhett Morton, Lyndal Anderson, Jonathan Carter, Selvan Pather, Samir A Saidi
OBJECTIVES: Intraoperative frozen section (IFS) offers a rapid test to guide the extent of surgery, which is essential for optimal treatment of ovarian cancer. This study evaluated the diagnostic performance and influence of IFS in the surgical management of ovarian tumors. METHODS: A retrospective review was conducted of IFS of adnexal lesions from 2008 to 2013, with diagnoses classified as benign, borderline, or malignant. The diagnostic performance of IFS was calculated, with a focus on primary epithelial tumors...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27918876/awareness-of-identity-alteration-and-diagnostic-preference-between-borderline-personality-disorder-and-dissociative-disorders
#5
Vedat Sar, Firdevs Alioğlu, Gamze Akyuz, Emre Tayakısı, Ezgi F Öğülmüş, Doğuş Sönmez
AIM: This study inquires into identity alteration among college students and its relationship to borderline personality disorder (BPD) and/or dissociative disorders (DDs). METHODS: Steinberg Identity Alteration Questionnaire (SIAQ), Childhood Trauma Questionnaire (CTQ), and self-report screening tool of the BPD section of the Structured Clinical Interview for DSM-IV (SCID-BPD) were administered to 1301 college students. Participants who fit the diagnostic criteria of BPD (n = 80) according to the clinician-administered SCID-BPD and 111 non-BPD controls were evaluated using the Structured Clinical Interview for DSM-IV DDs (SCID-D) by two psychiatrists blind to the group membership and scale scores...
December 5, 2016: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/27914664/-overdiagnosis-when-people-receive-a-diagnosis-they-do-not-need
#6
EDITORIAL
Remedios Martin Alvarez, Salvador Tranche Iparraguirre
No abstract text is available yet for this article.
December 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27913545/what-have-we-learned-from-large-population-studies-of-von-willebrand-disease
#7
Robert R Montgomery, Veronica H Flood
Von Willebrand factor (VWF) is a critical regulator of hemostatic processes, including collagen binding, platelet adhesion, and platelet aggregation. It also serves as a carrier protein to normalize plasma factor VIII synthesis, release, and survival. While VWF protein measurements by immunoassay are reasonably comparable between institutions, the measurement of VWF ristocetin cofactor activity (VWF:RCo) has significant variability. Other tests of VWF function, including collagen binding or platelet glycoprotein IIb-IIIa binding, are not universally available, yet these functional defects may cause major bleeding even with normal VWF antigen (VWF:Ag) and VWF:RCo assays...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27910903/prostate-cancer-patients-negative-biopsy-controls-discrimination-by-untargeted-metabolomics-analysis-of-urine-by-lc-qtof-upstream-information-on-other-omics
#8
M A Fernández-Peralbo, E Gómez-Gómez, M Calderón-Santiago, J Carrasco-Valiente, J Ruiz-García, M J Requena-Tapia, M D Luque de Castro, F Priego-Capote
The existing clinical biomarkers for prostate cancer (PCa) diagnosis are far from ideal (e.g., the prostate specific antigen (PSA) serum level suffers from lack of specificity, providing frequent false positives leading to over-diagnosis). A key step in the search for minimum invasive tests to complement or replace PSA should be supported on the changes experienced by the biochemical pathways in PCa patients as compared to negative biopsy control individuals. In this research a comprehensive global analysis by LC-QTOF was applied to urine from 62 patients with a clinically significant PCa and 42 healthy individuals, both groups confirmed by biopsy...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903502/overdiagnosis-of-thyroid-cancer
#9
EDITORIAL
Louise Davies
No abstract text is available yet for this article.
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27897042/state-of-the-art-pulmonary-ct-angiography-for-acute-pulmonary-embolism
#10
Moritz H Albrecht, Matthew W Bickford, John W Nance, Longjiang Zhang, Carlo N De Cecco, Julian L Wichmann, Thomas J Vogl, U Joseph Schoepf
OBJECTIVE: Pulmonary CT angiography (CTA) is the imaging modality of choice in suspected acute pulmonary embolism (PE). Current pulmonary CTA techniques involve ever lower doses of contrast medium and radiation along with advanced postprocessing applications to enhance image quality, diagnostic accuracy, and provide added value in patient management. The objective of this article is to summarize these current developments and discuss the appropriate use of state-of-the-art pulmonary CTA...
November 29, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27894707/missteps-in-current-estimates-of-cancer-overdiagnosis
#11
Christoph I Lee, Ruth Etzioni
The balance between the benefits and harms of imaging-based cancer screening continues to be an area of controversy and widespread media attention. Of the potential harms, overdiagnosis from screening is likely the most elusive in estimating and quantifying. This article describes the major methodological issues with recently reported estimates of overdiagnosis that are based on excess cancer incidence, and suggests that modeling focused on tumor lead-time can serve as a complementary method for excess incidence-based overdiagnosis estimates...
November 25, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27888850/mr-imaging-of-the-pediatric-foot-and-ankle-what-does-normal-look-like
#12
REVIEW
Grace Mang Yuet Ma, Kirsten Ecklund
MR imaging is ideally suited for characterization of the soft tissue, cartilaginous, and osseous structures of the pediatric ankle. An understanding of the normal MR imaging appearance associated with the dynamic skeletal maturation process will prevent overdiagnosis and unnecessary treatment. In this article, we review the normal MR imaging appearance of the growing ankle as well as several disease processes unique to the pediatric population.
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27876036/diabetes-screening-intervals-based-on-risk-stratification
#13
Sachiko Ohde, Emily McFadden, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera, Zentaro Yamagata
BACKGROUND: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes. METHODS: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27871502/screening-for-abdominal-aortic-aneurysm-in-asymptomatic-adults
#14
REVIEW
Muhammad Usman Ali, Donna Fitzpatrick-Lewis, John Miller, Rachel Warren, Meghan Kenny, Diana Sherifali, Parminder Raina
BACKGROUND: This report was produced for the Canadian Task Force on Preventive Health Care to provide guidelines on screening for abdominal aortic aneurysm (AAA) with ultrasound scan. PURPOSE: The aim of this systematic review is to examine the evidence on benefits and harms of AAA screening. SEARCH STRATEGY: This systematic review considered studies from the most recent United States Preventive Services Task Force review on AAA screening and passed through the screening process with citations identified in our search up to April 2015 (PROSPERO Registration #CRD42015019047)...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27866427/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis-author-reply
#15
Ji-Hoon Kim, Jung Hwan Baek, Jin Yong Sung, Dong Gyu Na
No abstract text is available yet for this article.
December 1, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27866424/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis
#16
Giovanni Mauri, Luca Maria Sconfienza
No abstract text is available yet for this article.
November 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27866218/prevalence-of-negative-ct-scans-in-a-level-one-trauma-center
#17
C K Hansen, R J Strayer, B D Shy, S Kessler, S Givre, K H Shah
PURPOSE: The rise of computed tomography (CT) use in trauma has become the subject of concern given the harms of CT including radiation, cost, over diagnosis and identification of incidental lesions. We developed a novel metric, the Negative CT Score, (∑CT-) which quantifies how often CT imaging identifies important injuries. Our objective was to describe the pattern of CT utilization in trauma at an urban academic level one trauma center using this novel metric. METHODS: This was a retrospective study of intermediate level trauma patients who received CT imaging over a 1-year study period at an urban level one trauma center...
November 19, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/27854006/mammography-an-update-of-the-eusobi-recommendations-on-information-for-women
#18
Francesco Sardanelli, Eva M Fallenberg, Paola Clauser, Rubina M Trimboli, Julia Camps-Herrero, Thomas H Helbich, Gabor Forrai
: This article summarises the information to be offered to women about mammography. After a delineation of the aim of early diagnosis of breast cancer, the difference between screening mammography and diagnostic mammography is explained. The need to bring images and reports from the previous mammogram (and from other recent breast imaging examinations) is highlighted. Mammography technique and procedure are described with particular attention to discomfort and pain experienced by a small number of women who undergo the test...
November 16, 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27853066/concentrations-of-immunoglobulin-g-antibodies-against-pertussis-toxin-does-not-decrease-over-a-long-period-of-time-in-japan
#19
Yumi Sakakibara, Yoshio Ohtani, Torahiko Jinta, Toshihide Fujie, Yasunari Miyazaki, Naohiko Inase, Ryoichi Saito, Miho Akaza, Tetsuo Sasano, Yuki Sumi
Objective Adult patients with pertussis rarely show typical symptoms, such as paroxysmal coughing, inspiratory "whoop", or post-tussive vomiting. While a culture is regarded as the gold standard for diagnosis, the sensitivity is very low. Therefore, the diagnosis of pertussis in adults in clinical practice is mostly based on single-sample serology using an enzyme-linked immunosorbent assay (ELISA) with the pertussis toxin antigen. Various cut-off values for the anti-pertussis toxin IgG (PT-IgG) have been proposed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27848107/defining-disease-in-the-context-of-overdiagnosis
#20
Mary Jean Walker, Wendy Rogers
Recently, concerns have been raised about the phenomenon of 'overdiagnosis', the diagnosis of a condition that is not causing harm, and will not come to cause harm. Along with practical, ethical, and scientific questions, overdiagnosis raises questions about our concept of disease. In this paper, we analyse overdiagnosis as an epistemic problem and show how it challenges many existing accounts of disease. In particular, it raises questions about conceptual links drawn between disease and dysfunction, harm, and risk...
November 15, 2016: Medicine, Health Care, and Philosophy
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