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Fulminant hepatitis

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https://www.readbyqxmd.com/read/29145204/comparing-the-clinical-features-and-outcomes-of-acute-hepatitis-e-viral-infections-with-those-of-acute-hepatitis-a-b-and-c-infections-in-korea
#1
Hye Won Oh, Ra Ri Cha, Sang Soo Lee, Chang Min Lee, Wan Soo Kim, Yun Won Jo, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee
OBJECTIVES: This study investigated the etiology of acute viral hepatitis and compared the clinical features of hepatitis E virus (HEV) infections with those of other acute viral hepatitis infections in Korea. METHODS: This study included 2,357 consecutive patients who were diagnosed with acute hepatitis, based on acute illness with jaundice or elevated alanine aminotransferase levels (>100 IU/L), between January 2007 and January 2016. Acute viral infections were observed in 23 (19...
November 17, 2017: Intervirology
https://www.readbyqxmd.com/read/29115027/clinical-features-of-pediatric-autoimmune-hepatitis-in-japan-a-nationwide-survey
#2
Tsuyoshi Sogo, Atsushi Takahashi, Ayano Inui, Tomoo Fujisawa, Hiromasa Ohira, Hajime Takikawa
AIM: The purpose of this study was to determine the characteristics of children with autoimmune hepatitis (AIH) in Japan. METHODS: Questionnaires, which asked about patients newly diagnosed with AIH from 2009 to 2013 were sent to hospitals certified as training facilities for pediatrics in January 2015. RESULTS: A total of 35 patients were enrolled. The median age at diagnosis was 10 years (ranging from 3 months to 15 years), and the male-to-female ratio was 2:3...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29113002/-acute-liver-failure-as-a-rare-case-of-a-frequent-disease
#3
Angela Marie Thiel, Jürgen Rissland, Frank Lammert, Markus Casper
Here we report the case of a 63-year-old female patient who was admitted with acute liver failure. The etiology turned out to be an acute fulminant hepatitis caused by hepatitis C virus (HCV) infection of unknown origin. Fulminant hepatitis due to acute hepatitis C is very rare and hardly reported but a potential cause of acute liver failure due to massive hepatic necrosis, which may lead to encephalitis and multi-organ-failure. During follow-up spontaneous virological clearance was observed. The case illustrates that acute HCV infection, which is confirmed by the detection of HCV-RNA, has to be considered in the differential diagnosis of acute liver failure...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29109438/vsig4-inhibits-proinflammatory-macrophage-activation-by-reprogramming-mitochondrial-pyruvate-metabolism
#4
Jialin Li, Bo Diao, Sheng Guo, Xiaoyong Huang, Chengying Yang, Zeqing Feng, Weiming Yan, Qin Ning, Lixin Zheng, Yongwen Chen, Yuzhang Wu
Exacerbation of macrophage-mediated inflammation contributes to pathogenesis of various inflammatory diseases, but the immunometabolic programs underlying regulation of macrophage activation are unclear. Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein that is expressed by resting macrophages, inhibits macrophage activation in response to lipopolysaccharide. Vsig4 (-/-) mice are susceptible to high-fat diet-caused obesity and murine hepatitis virus strain-3 (MHV-3)-induced fulminant hepatitis due to excessive macrophage-dependent inflammation...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29107021/historical-perspectives-and-advances-in-the-mesenchymal-stem-cell-research-for-the-treatment-of-liver-diseases
#5
REVIEW
Chien-Wei Lee, Yu-Fan Chen, Hao-Hsiang Wu, Oscar K Lee
Liver transplantation is the only effective therapy for patients with decompensated cirrhosis and fulminant liver failure. However, due to a shortage of donor livers and complications associated with immune suppression, there is an urgent need for new therapeutic strategies for patients with end-stage liver diseases. Given their unique function in self-renewal and differentiation potential, stem cells might be used to regenerate damaged liver tissue. Recent studies have shown that stem cell-based therapies can improve liver function in a mouse model of hepatic failure...
October 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29090278/alleviation-of-lipopolysaccharide-d-galactosamine-induced-liver-injury-in-leukocyte-cell-derived-chemotaxin-2-deficient-mice
#6
Akinori Okumura, Takeshi Saito, Minoru Tobiume, Yuki Hashimoto, Yuko Sato, Takashi Umeyama, Minoru Nagi, Koichi Tanabe, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hideki Hasegawa, Yoshitsugu Miyazaki, Satoshi Yamagoe
Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted pleiotropic protein that is mainly produced by the liver. We have previously shown that LECT2 plays an important role in the pathogenesis of inflammatory liver diseases. Lipopolysaccharide/d-galactosamine (LPS/d-GalN)-induced acute liver injury is a known animal model of fulminant hepatic failure. Here we found that this hepatic injury was alleviated in LECT2-deficient mice. The levels of TNF-α and IFN-γ, which mediate this hepatitis, had significantly decreased in these mice, with the decrease in IFN-γ production notably greater than that in TNF-α...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29088996/aggressive-treatment-of-life-threatening-hypophosphatemia-during-recovery-from-fulminant-hepatic-failure-a-case-report
#7
Brittany D Bissell, Jason E Davis, Alexander H Flannery, David A Adkins, Melissa L Thompson Bastin
Acute liver failure secondary to acetaminophen overdose can be a life-threatening condition, characterized by severe electrolyte derangements. Hepatocyte regeneration is associated with phosphorous utilization and is a known complication of liver recovery following injury. We report the case of profound, life-threatening hypophosphatemia following recovery from acute fulminant liver failure. As the liver enzymes normalized, serum phosphorous levels plummeted. Our patient required an aggressive, individualized phosphorus replacement regimen, which resulted in a continuous infusion of intravenous (IV) sodium phosphate, titrated to a maximum rate of 30 mmol/h or 0...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29074353/clinical-features-of-regorafenib-induced-liver-injury-in-japanese-patients-from-postmarketing-experience
#8
Hiroyuki Uetake, Kenichi Sugihara, Kei Muro, Toshiyuki Sunaya, Yuka Horiuchi-Yamamoto, Hajime Takikawa
BACKGROUND: Regorafenib (Stivarga) is an oral multikinase inhibitor currently approved for patients with metastatic colorectal cancer or gastrointestinal stromal tumor. Although hepatotoxicity has been a known product profile feature of regorafenib since its initial approval, its clinical features are limited to those found in the clinical trials. PATIENTS AND METHODS: The present study was conducted in 2 analysis sets: a safety analysis set for metastatic colorectal cancer from solicited postmarketing surveillance (PMS) in Japan (n = 1227) and an analysis set for serious hepatic adverse drug reactions (n = 210) from all patients registered for regorafenib use...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29057809/hepatoprotective-effects-of-kaempferol-3-o-%C3%AE-l-arabinopyranosyl-7-o-%C3%AE-l-rhamnopyranoside-on-d-galactosamine-and-lipopolysaccharide-caused-hepatic-failure-in-mice
#9
Lin Dong, Lei Yin, Hongfeng Quan, Yuankui Chu, Jincai Lu
Fulminant hepatic failure (FHF), associated with high mortality, is characterized by extensive death of hepatocytes and hepatic dysfunction. There is no effective treatment for FHF. Several studies have indicated that flavonoids can protect the liver from different factor-induced injury. Previously, we found that the extracts of Elaeagnus mollis leaves had favorable protective effects on acute liver injury. However, the role and mechanisms behind that was elusive. This study examined the hepatoprotective mechanisms of kaempferol-3-O-α-l-arabinopyranosyl-7-O-α-l-rhamnopyra-noside (KAR), a major flavonol glycoside of E...
October 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29054137/il-35-gene-modified-mesenchymal-stem-cells-protect-the-con-a-induced-fulminant-hepatitis-through-decreasing-the-ifn-g-level
#10
Wei Wang, Hao Guo, Hongyue Li, Yongjia Yan, Chao Wu, Xiaodong Wang, Xianghui He, Na Zhao
Interleukin 35 (IL-35) is a relatively newly identified cytokine required for the regulatory and suppressive functions of regulatory T cells(Treg), playing an important role in the prevention of autoimmune diseases. In this study, we used the MSCs as the gene-delivery vehicles for IL-35 gene therapy and investigated their protective effects in Con A-induced autoimmune hepatitis. Results showed that IL-35 gene modified MSCs(IL-35-MSCs) can specifically migrate to the injured liver tissues and significantly narrow the necrosis areas and reduce the hepatocytes apoptosis...
October 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29041955/pluripotent-nontumorigenic-multilineage-differentiating-stress-enduring-cells-muse-cells-a-seven-year-retrospective
#11
REVIEW
Samantha C Fisch, María L Gimeno, Julia D Phan, Ariel A Simerman, Daniel A Dumesic, Marcelo J Perone, Gregorio D Chazenbalk
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers...
October 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29024015/hepatobiliary-and-pancreatic-fulminant-liver-failure-from-diffuse-leukemoid-hepatic-infiltration-of-melanoma
#12
B Schlevogt, J Rehkämper, B Hild, H H Schmidt
No abstract text is available yet for this article.
November 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28994560/epidemiology-and-pathogenesis-of-fulminant-viral-hepatitis-in-pregnant-women-a-review
#13
Grazia Tosone, Davide Simeone, Anna M Spera, Giulio Viceconte, Vincenzo Bianco, Raffaele Orlando
The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant failure reported in the literature had been related to Hepatits E Virus mainly and had been concentrated in Indian subcontinent and some African areas, whereas the problem seems to be very low or absent in the remaining geographical areas...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28993518/naringenin-ameliorates-acute-inflammation-by-regulating-intracellular-cytokine-degradation
#14
Lingtao Jin, Wenfeng Zeng, Fayun Zhang, Chunling Zhang, Wei Liang
Ungoverned activation of innate and adaptive immunity results in acute inflammatory disease, such as bacteria-induced endotoxemia and fulminant hepatitis by virus infection. Thus, therapeutic control of inflammation is crucial for clinical management of many human diseases. In murine models of LPS- and Con A-induced liver injury, we found that naringenin, a natural predominant flavanone, is capable of protecting against lethality induced by LPS and preventing inflammation-induced organ injury. The protective effect of naringenin is mediated by reducing the levels of several inflammatory cytokines...
October 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28957471/malarial-hepatopathy-a-6-year-retrospective-observational-study-from-uttarakhand-north-india
#15
Nidhi Kaeley, Sohaib Ahmad, Nadia Shirazi, Rohan Bhatia, Nowneet K Bhat, Saurabh Srivastava, Minakshi Dhar, Manoj Kumar
Background: Jaundice in malaria is multifactorial. Plasmodium falciparum causes malarial hepatopathy in around 2.5% of cases. The spectrum of hepatic dysfunction in patients with malaria varies from mild clinical and biochemical abnormalities to fulminant hepatic failure, although hepatic encephalopathy almost never occurs. We undertook this study in order to estimate the magnitude of hepatopathy in malaria, and study the associated clinical features, complications and outcome of patients...
May 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28953903/interleukin-1%C3%AE-and-interleukin-1%C3%AE-play-a-central-role-in-the-pathogenesis-of-fulminant-hepatic-failure-in-mice
#16
Maya Sultan, Ziv Ben-Ari, Rula Masoud, Orit Pappo, Dror Harats, Yehuda Kamari, Michal Safran
BACKGROUND AND AIMS: Fulminant hepatitis failure (FHF) is marked by the sudden loss of hepatic function, with a severe life-threatening course in persons with no prior history of liver disease. Interleukin (IL)-1α and IL-1β are key inflammatory cytokines but little is known about their role in the development of FHF. The aim of this study was to assess the involvement of IL-1α and IL-1β in the progression of LPS/GalN-induced FHF. METHODS: WT, IL-1α or IL-1β deficient mice were injected with LPS/GalN...
2017: PloS One
https://www.readbyqxmd.com/read/28952677/a-cluster-of-hepatitis-a-viral-infection-in-hse-south
#17
H A Ferris, A Dillon, M B O'Sullivan
Hepatitis A is an acute viral infection of the liver that produces clinical features ranging from asymptomatic infection to fulminant hepatitis(1). The authors report a cluster of 5 serologically-confirmed cases of acute Hepatitis A Virus (HAV), all serum IgM positive for HAV Genotype 1A. This is on a background of only 2 other cases notified to HSE-South in 2016 to date, both travel related. There was a considerable delay in notification in two out of 5 cases. This case report highlights the importance of prompt notification of Hepatitis A, as timely notification would have facilitated prompt contact vaccination and might well have prevented illness in two subsequent household contacts...
June 9, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28951776/hepatitis-b-in-patients-with-hematological-diseases-an-update
#18
REVIEW
Chiara Coluccio, Paola Begini, Alfredo Marzano, Adriano Pellicelli, Barbara Imperatrice, Giulia Anania, Gianfranco Delle Fave, Massimo Marignani
Hepatitis B virus (HBV) reactivation (HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28951695/acute-non-fulminant-viral-hepatitis-e-presenting-with-acute-pancreatitis-an-unusual-presentation
#19
Ayusmati Thakur, Partha Pratim Basu
Acute pancreatitis is considered to be an extremely rare extrahepatic manifestation of acute viral hepatitis E. The incidence is reported to be around 5%-6% in the available case series. It has usually been reported in non-fulminant cases of acute viral hepatitis E in the second or third week of illness, with a favourable outcome. Here, we report the case of a young male subject with acute viral hepatitis E presenting as acute pancreatitis at its onset and exhibiting a prolonged recovery phase. To the authors' knowledge, such a presentation of acute viral hepatitis E as acute pancreatitis at its inception has been only sparsely reported in the available literature...
August 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28912916/acute-liver-failure-in-a-patient-travelling-from-asia-the-other-face-of-the-coin-of-infectious-disease
#20
Balen Abdulrahman, Mohamed H Ahmed, John Ramage
We present a case of a 63-year-old male who had travelled from South India to United Kingdom (UK) visiting relatives. He had developed episodes of diarrhea, vomiting and fevers while travelling and on assessment in hospital, mild abdominal distension was noted with rapid deterioration to hypovolemic shock. Initial blood test showed a low platelet count with deranged liver function tests (LFTs). It was noted that during admission to intensive care unit (ICU), blood continued to ooze from a previous surgical laparoscopy wound, central and arterial line access sites...
August 2017: Gastroenterology Research
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