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Yoichi Oikawa, Hajime Tanaka, Junko Uchida, Yoshihiro Atsumi, Masaya Osawa, Takeshi Katsuki, Toshihide Kawai, Akira Shimada
Slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM), believed to be caused by β-cell destruction through islet-cell autoimmunity, gradually progresses to an insulin-dependent state over time. Although the presence of anti-glutamic acid decarboxylase antibody (GADA) is required for the diagnosis of SPIDDM, a recent change in the GADA assay kit from radioimmunoassay (RIA) to enzyme-linked immunosorbent assay (ELISA) yields mismatched GADA test results between the two kits, leading to confusion in understanding the pathological conditions of SPIDDM in Japan...
October 18, 2016: Endocrine Journal
Thashi Chang, Bethan Lang, Angela Vincent
BACKGROUND: Stiff person syndrome is a highly disabling, progressive autoimmune disorder of the central nervous system characterized by muscle rigidity and spasms. Stiff person syndrome is rare, but is believed to be under diagnosed with only 14 cases been reported among a 1.7 billion population in South Asia. We report the first authenticated case from Sri Lanka. CASE PRESENTATION: A 55-year-old Sri Lankan female presented with difficulty in walking and recurrent falls due to progressive muscular rigidity in her lower limbs and trunk with superimposed muscle spasms that occurred in response to unexpected noise, startle or emotional upset...
October 18, 2016: BMC Research Notes
Hiroyuki Hirai, Sanae Midorikawa, Shinichi Suzuki, Hironobu Sasano, Tsuyoshi Watanabe, Hiroaki Satoh
We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5...
2016: Internal Medicine
TingYu Liu, BuChin Yu, Mamoru Kakino, Hitoshi Fujimoto, Yasutoshi Ando, Fumihiko Hakuno, Shin-Ichiro Takahashi
Insulin receptor substrates (IRSs) are major targets of insulin receptor tyrosine kinases. Here we identified diacylglycerol kinase zeta (DGKζ) as an IRS-1-associated protein, and examined roles of DGKζ in glucose transporter 4 (GLUT4) translocation to the plasma membrane. When DGKζ was knocked-down in 3T3-L1 adipocytes, insulin-induced GLUT4 translocation was inhibited without affecting other mediators of insulin-dependent signaling. Similarly, knockdown of phosphatidylinositol 4-phosphate 5-kinase 1α (PIP5K1α), which had been reported to interact with DGKζ, also inhibited insulin-induced GLUT4 translocation...
October 14, 2016: Scientific Reports
Jitu V Thomas, Rajeev Philip, C S Kesavan, Shalu Mariam, Abdul Khader
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Frédéric Capel, Naoufel Cheraiti, Cécile Acquaviva, Carole Hénique, Justine Bertrand-Michel, Christine Vianey-Saban, Carina Prip-Buus, Béatrice Morio
Because the protective effect of oleate against palmitate-induced insulin resistance may be lessened in skeletal muscle once cell metabolism is overloaded by fatty acids (FAs), we examined the impact of varying amounts of oleate on palmitate metabolic channeling and insulin signaling in C2C12 myotubes. Cells were exposed to 0.5mM of palmitate and to increasing doses of oleate (0.05, 0.25 and 0.5mM). Impacts of FA treatments on radio-labelled FA fluxes, on cellular content in diacylglycerols (DAG), triacylglycerols (TAG), ceramides, acylcarnitines, on PKCθ, MAPKs (ERK1/2, p38) and NF-ΚB activation, and on insulin-dependent Akt phosphorylation were examined...
October 8, 2016: Biochimica et Biophysica Acta
Rebecca Johnson
Dive medicine bodies worldwide recognise that, with comprehensive screening and careful management, people with insulin-dependent diabetes (IDDM) can dive safely. Despite this, people with IDDM in Australia are generally denied access to dive training, an out-dated status quo that is not acceptable to the Australian diabetes community. This paper reflects upon the important advocacy work that has been done to progress this issue, and what is still required to open up access and bring Australia into line with more flexible and supportive international standards...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Rebecca Johnson
Some people with well-managed insulin-dependent diabetes can dive safely. Those cleared to participate should control tightly the variables that impact blood glucose levels, including activity, timing, food and insulin. Honest self-assessment is critical. A diabetic diver should cancel a dive if seasick, unusually anxious, or following significant high or low blood glucose levels in the preceding 24 hours. The diver should enter the water with a blood glucose level above 8.3 mmol·L⁻¹ and below 14 mmol·L⁻¹ with a stable or rising trend in blood glucose established with glucose tests at 90, 60, and 30 minutes prior to a dive...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Su-Yeon Kang, Youngsub Eom, Jay Won Rhim, Jong Suk Song, Hyo Myung Kim
PURPOSE: To report a case of intraocular lens (IOL) glistening after uneventful cataract surgery and in-the-bag implantation of an enVista MX60 IOL (Bausch & Lomb, Rochester, NY) in a patient with uncontrolled diabetes mellitus. METHODS: Case report. RESULTS: A 76-year-old woman with non-insulin-dependent diabetes mellitus underwent uncomplicated phacoemulsification with in-the-bag implantation of an enVista MX60 IOL. After 6 months, glistening formation within the IOL optic was observed...
October 1, 2016: Journal of Refractive Surgery
Alessandro D Genazzani
Studies over the last decade have demonstrated that some polycystic ovary syndrome (PCOS) patients have abnormal insulin sensitivity (insulin resistance), independently from being overweight or obese. This induces the risk of developing type 2 diabetes in such PCOS patients. The use of insulin sensitizers (i.e. metformin), reduces such metabolic, and most hormonal, impairments. As metformin often induces side effects, new integrative strategies have been proposed to treat insulin resistance, such as the use of inositols...
September 16, 2016: Reproductive Biomedicine Online
Aleksandra Velickov, Olivera Mitrovic, Branka Djordjevic, Dusan Sokolovic, Vladimir Zivkovic, Asen Velickov, Vukica Pantovic, Natasa Poklar Urlih, Goran Radenkovic
Diabetic gastroenteropathy involves not only the parasympathetic and sympathetic autonomic nerves, but also enteric neurons, smooth muscle cells and interstitial cells of Cajal (ICC). ICC are the cells of mesenchymal origin that occur within and around the muscle layers in the gastrointestinal tract. The objective of the present study was to investigate the alterations of ICC in the lower oesophageal sphincter (LOS) of streptozotocin-nicotinamide non-insulin-dependent diabetes rats. Moreover, we investigated possible ICC in rats with the same type of diabetes, treated with bilberry fruit extract, bearing in mind that its hypoglycemic effect had been already proven...
October 5, 2016: Histology and Histopathology
Satoru Wakabayashi, Naoya Sawamura, André Voelzmann, Meike Broemer, Toru Asahi, Michael Hoch
Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that is highly conserved in animals and plants. CRBN proteins have been implicated in various biological processes such as development, metabolism, learning and memory formation and their impairment has been linked to autosomal recessive non-syndromic intellectual disability and cancer. Furthermore, human CRBN was identified as the primary target of thalidomide teratogenicity. Data on functional analysis of CRBN family members in vivo is, however, still scarce...
October 4, 2016: Journal of Biological Chemistry
Cosimo D'Alessandro, Jean Louis Golmard, Guillaume Lebreton, Mojgan Laali, Shaida Varnous, Patrick Farahmand, Charles Vidal, Pascal Leprince
OBJECTIVES: The 'Special Urgency1' (SU1) offers a 48-h national priority for critically ill cardiac recipients in France. We evaluated our experience of high-urgency cardiac transplantation. METHODS: Between January 2005 and December 2012, 265 patients met the criteria for SU1 waiting list enrolment at our Institution: 212 patients were transplanted during the SU1 priority period, whereas 53 patients missed SU1 priority donor allocation and were downgraded to the standard waiting list...
October 2, 2016: European Journal of Cardio-thoracic Surgery
Zhu Li, Julie L Frey, G William Wong, Marie-Claude Faugere, Michael J Wolfgang, Jason K Kim, Ryan C Riddle, Thomas L Clemens
Recent studies have identified the osteoblast as an insulin responsive cell that participates in global energy homeostasis. Here we show that Glut4 is required for insulin-dependent uptake and oxidation of glucose in mature osteoblasts. In primary cultures of mouse osteoblasts, insulin increased uptake and oxidation of (14)C-glucose in a dose-dependent fashion, but did not significantly affect uptake or oxidation of (14)C-oleate. In vitro, undifferentiated osteoblasts expressed three high affinity glucose transporters: Glut1, Glut4, and Glut3...
September 30, 2016: Endocrinology
Eilif Dahl
A 66-year-old overweight insulin-dependent male passenger with diabetes and severe arthritis was on a 4-week circle-Pacific cruise. He fell ashore and hit his head. The ship was about to leave on a non-stop voyage - without any evacuation possibilities for the next 8 days. He was examined and had X-rays taken at the local hospital, but as his head injury was considered mild, he returned to the ship "for 48 hours of observation for signs of intracranial bleeding" - against the ship's doctor's advice. Delayed suspicion of a non-displaced cervical fracture caused extra work and worries and could have, but did not complicate matters...
2016: International Maritime Health
Laura Tariciotti, Stefano D'Ugo, Tommaso Maria Manzia, Valeria Tognoni, Giuseppe Sica, Paolo Gentileschi, Giuseppe Tisone
INTRODUCTION: Obesity is a contributor to the global burden of chronic diseases, including non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH). NASH cirrhosis is becoming a leading indication for liver transplant (LT). Obese transplanted patients have higher morbidity and mortality rates. One strategy, to improve the outcomes in these patients, includes bariatric surgery at the time of LT. Herein we report the first European combined LT and sleeve gastrectomy (SG)...
September 21, 2016: International Journal of Surgery Case Reports
Karima Belhaj, Soumia Meftah, Laila Mahir, Fatima Lmidmani, Abdellatif Elfatimi
OBJECTIVE: Diabetic foot includes all foot abnormalities in diabetics; they are secondary to several pathophysiological mechanisms. Few studies have compared the two types of diabetes for podiatric complications. The objective of this work is to make a comparative study of podiatry profile, clinical, optical and electronic podoscopique between insulin-dependent diabetes (IDDM) and non-insulin dependent (NIDDM). MATERIALS/PATIENTS AND METHODS: This is a prospective study over one year, including diabetic patients who have been made, an optical podocopique review and static and dynamic electronics...
September 2016: Annals of Physical and Rehabilitation Medicine
Gaurav Aman Luther, Praveen Murthy, Philip E Blazar
PURPOSE: As health care costs continue to rise, providers must increasingly identify and implement cost-effective practice measures without sacrificing quality of care. Corticosteroid injections are an established treatment for trigger finger; however, numerous clinical trials have documented the limited efficacy of these injections in the diabetic population. Furthermore, the most cost-effective treatment strategy for diabetic trigger finger has not been determined. The purpose of this study was to perform a decision analysis to identify the least costly strategy for effective treatment of diabetic trigger finger using existing evidence in the literature...
September 23, 2016: Journal of Hand Surgery
Tulin Demir, Mumtaz Dadali
Sphingomonas paucimobilis is an aerobic, oxidase-positive, yellow-pigmented, non-fermentative, Gram-negative opportunistic pathogen that rarely causes infections in humans. It is commonly found in nosocomial environments and, despite its low clinical virulence, it can be responsible for several different infections especially among patients with underlying disease. Here we describe a clinical case of a 46-year-old male paraplegic patient with a history of neurogenic bladder due to insulin-dependent diabetes mellitus and renal failure who was admitted to the urology clinic of a university hospital in Kirsehir, Turkey, with the complaints of urinary tract infection (UTI) including fever, chills, dysuria, abdominal and back pain...
September 1, 2016: Le Infezioni in Medicina
Simon Fong, Dana Wang, Jinan Fiaidhi, Sabah Mohammed, Libo Chen, Li Ling
Clinical pathways are part of the diabetes therapy management which involves medical interventions versus the patient's conditions. For instance, in insulin-dependent diabetes mellitus (IDDM), a right amount of insulin dosage and the timings of its intake are needed for each individual patient, so to maintain an appropriate blood glucose level for his/her body. Although some general health guidelines are available, they are general and not personalized. The interactions between the medicine, the lifestyles and the patient's conditions are complex; the dosages and the pattern of therapy may differ from one patient to another...
July 5, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
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