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https://www.readbyqxmd.com/read/29457302/innate-lymphoid-cells-at-the-human-maternal-fetal-interface-in-spontaneous-preterm-labor
#1
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29454785/lymphoid-tissue-inducer-a-divergent-member-of-the-ilc-family
#2
REVIEW
Chao Zhong, Mingzhu Zheng, Jinfang Zhu
Innate lymphoid cells (ILCs) that are capable of producing effector cytokines reminiscent of CD4+ T helper (Th) cells during infections and tissue inflammations have drawn much attention in the immunology field in recent years. Within the ILCs, the lymphoid tissue inducer (LTi) cells that play a critical role in lymphoid organogenesis were identified long before the establishment of the ILC concept. LTi cells, developed and functioning mainly at the fetal stage, and LTi-like cells, presumably generated during the adulthood, are regarded as a subset of type 3 ILCs (ILC3s) because they express the ILC3 lineage-defining transcription factor RORγt, and like other ILC3s, can produce an ILC3 signature cytokine IL-22 and initiate protective immune responses against extracellular bacteria...
February 13, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29448007/dysfunction-of-cd3-cd16-cd56-dim-and-cd3-cd16-cd56-bright-nk-cell-subsets-in-rr-ms-patients
#3
Ilhan Tahrali, Umut Can Kucuksezer, Ayse Altintas, Ugur Uygunoglu, Nilgun Akdeniz, Esin Aktas Cetin, Gunnur Deniz
Multiple sclerosis (MS), is a chronic inflammatory disease of central nervous system with unclear etiology. Relapsing-remitting (RR)-MS is the most frequent subtype of disease. Natural Killer (NK) cells have roles in cytotoxicity and immune regulation by cytokine secretions, with uncertain contribution to MS pathogenesis. This study aimed to explore contribution of NK cells to MS pathogenesis. Percentages of CD3 - CD16 + CD56 + total NK cells, CD3 - CD16 + CD56 dim and CD3 - CD16 - CD56 bright NK cell subsets, NK cytotoxicity and intracellular IFN-γ, IL-10 and IL-22 levels were investigated in patients with RR-MS and clinically isolated syndrome (CIS) as well as healthy subjects...
February 12, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29445365/-babesia-microti-infection-changes-host-spleen-architecture-and-is-cleared-by-a-th1-immune-response
#4
Vitomir Djokic, Lavoisier Akoolo, Nikhat Parveen
Babesia microti is a malaria-like parasite, which infects ∼2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested only after they feel ill. Susceptible C3H/HeJ mice show several human-like disease manifestations and are ideal to study pathogenesis of Babesia species. In this study, we examined parasitemia of B. microti at different time points and assessed its impact on hemoglobin levels in blood, on spleen pathology and overall immune response in C3H/HeJ mice...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29421775/increased-urine-interleukin-17-and-interleukin-22-levels-in-patients-with-candidal-urinary-tract-infection
#5
Kazem Ahmadikia, Parivash Kordbacheh, Pejman Shadpour, Sanam Nami, Abdolfattah Sarrafnejad, Mahmood Mahmoodi, Mahin Safara, Mohsen Rokni, Mohammad Yarahmadi, Shahram Mahmoudi, Mahdis Khezri, Farideh Zaini
INTRODUCTION: Candiduria is common in the hospitalized patients. This study aimed to quantify interleukin (IL)-17 and IL-22 levels in urine of candiduric patients. MATERIALS AND METHODS: A case-control study was conducted on inpatients at Hashemi Nejad Kidney Center. Thirty-four patients were identified with Candida species in their urine samples (> 103 colony-forming units per milliliter and presence of Candida species only). Urine samples with concomitant infections were excluded...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29416693/serum-levels-of-adipokines-and-cytokines-in-psoriasis-patients-a-systematic-review-and-meta-analysis
#6
Fan Bai, Wen Zheng, Yan Dong, Juan Wang, Malgorzata A Garstka, Ruilian Li, Jingang An, Huiqun Ma
Purpose: To evaluate the association of serum levels of adipokines and cytokines with psoriasis. Materials and Methods: A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in serum marker levels between patients and controls were pooled as standardized mean differences (SMDs) with 95% confidence interval to combine the effect estimations. We also conducted stratified analysis, meta-regression analysis and sensitivity analysis...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29409331/lactobacillus-salivarius-la307-and-lactobacillus-rhamnosus-la305-attenuate-skin-inflammation-in-mice
#7
S Holowacz, C Blondeau, I Guinobert, A Guilbot, S Hidalgo, J F Bisson
Oral probiotics potential for the management of dermatological diseases is vast. However, results of available studies in skin diseases, such as atopic dermatitis (AD), are inconsistent, partly because probiotic effects are strain specific. Careful selection of probiotic strains is therefore indispensable to ensure efficacy of treatment. In this study, Lactobacillus salivarius LA307, Lactobacillus rhamnosus LA305 and Bifidobacterium bifidum PI22, three strains that were previously identified for their interesting immunomodulatory properties in allergy and/or colitis models, were assessed in the prevention of chronic skin inflammation induced by repeated applications of 12-O-tetradecanoylphorbol-13-acetate in hairless SKH-1 mice...
February 7, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29401501/neutrophil-predominance-in-bronchoalveolar-lavage-fluid-is-associated-with-disease-severity-and-progression-of-hrct-findings-in-pulmonary-mycobacterium-avium-infection
#8
Takashi Inomata, Satoshi Konno, Katsura Nagai, Masaru Suzuki, Masaharu Nishimura
Pulmonary Mycobacterium avium complex (MAC) infection is increasing in prevalence worldwide even in immunocompetent individuals. Despite its variable clinical course, the clinical and immunological factors associated with radiographical severity and progression are not largely unknown. We aimed to study the association between the inflammatory cell and cytokine profiles at the local infected site, and the radiological severity and/or progression of pulmonary MAC infection. In this retrospective cohort study, 22 healthy subjects and 37 consecutive patients who were diagnosed as having pulmonary MAC infection by positive cultures of bronchoalveolar lavage (BAL) fluids were enrolled...
2018: PloS One
https://www.readbyqxmd.com/read/29396054/could-the-inhibition-of-il-17-or-il-18-be-a-potential-therapeutic-opportunity-for-gastric-cancer
#9
REVIEW
Paul M Nguyen, Tracy L Putoczki
Chronic inflammation is recognized as a key tumor-promoting factor in a number of epithelial cancers, including gastric cancer (GC). The production of pro-inflammatory cytokines in the tumor microenvironment by both the innate and the adaptive immune response can activate signaling pathways that are associated with increased cell survival and proliferation of cancer cells. Among the cytokines that have most commonly been linked to inflammation-associated cancers, are the Th17 cell-associated cytokines IL-17A, IL-23, IL-22, and the IL-1 family members IL-1β and IL-18...
January 29, 2018: Cytokine
https://www.readbyqxmd.com/read/29395573/increased-levels-of-lipocalin-2-in-palmoplantar-pustular-psoriasis
#10
Kerstin Wolk, Yvonne Frambach, Arnd Jacobi, Dagmar Wilsmann-Theis, Sandra Phillipp, Ellen Witte-Händel, Jörg Wenzel, Rotraut Mössner, Robert Sabat
BACKGROUND: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles. OBJECTIVE: To identify and characterize pathogenetic players in PPP. METHODS: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Healthy participants served as controls. Analysis of patient samples and cultured primary skin cells was performed by ELISA, qRT-PCR, and immunohistochemistry...
January 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29394345/roles-of-il-22-in-allergic-airway-inflammation-in-mice-and-humans
#11
Koichi Hirose, Takashi Ito, Hiroshi Nakajima
Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction. Although these pathognomonic features of asthma are primarily mediated by allergen-specific T helper type 2 cells (Th2 cells) and their cytokines, recent studies have revealed critical roles of lung epithelial cells in the pathogenesis of asthma. Lung epithelial cells not only form physical barriers by covering the surfaces of the airways but also sense inhaled allergens and initiate communication between the environment and the immune system...
January 31, 2018: International Immunology
https://www.readbyqxmd.com/read/29393435/il-22-inactivates-hepatic-stellate-cells-via-downregulation-of-the-tgf-%C3%AE-1-notch-signaling-pathway
#12
Enran Chen, Yu Cen, Donghong Lu, Wei Luo, Haixing Jiang
Interleukin-22 (IL-22) inhibits liver fibrosis by inducing hepatic stellate cell (HSC) senescence, primarily through the activation of signal transducer and activator of transcription 3 signaling. However, whether other signaling pathways are involved remains unknown. The present study assessed the regulatory mechanism between IL‑22 and the Notch signaling pathway in vitro. The results revealed that IL‑22 had anti‑proliferative effects on HSC‑T6 cells, and cellular inactivation was reflected by simultaneous inhibition of α‑smooth muscle actin, transforming growth factor-β1 (TGF‑β1), tumor necrosis factor-α and intercellular adhesion molecule 1...
January 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29391546/the-gs-nitroxide-jp4-039-improves-intestinal-barrier-and-stem-cell-recovery-in-irradiated-mice
#13
Liang Wei, Brian J Leibowitz, Michael Epperly, Cheng Bi, Allen Li, Justin Steinman, Peter Wipf, Song Li, Lin Zhang, Joel Greenberger, Jian Yu
Total body irradiation (TBI) leads to dose- and tissue-specific lethality. In the current study, we demonstrate that a mitochondrion-targeted nitroxide JP4-039 given once 24 hours after 9-10 Gy TBI significantly improves mouse survival, and the recovery of intestinal barrier, differentiation and stem cell functions. The GI-protective effects are associated with rapid and selective induction of tight junction proteins and cytokines including TGF-β, IL-10, IL-17a, IL-22 and Notch signaling long before bone marrow depletion...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29383167/dual-roles-of-il-22-at-ischemia-reperfusion-injury-and-acute-rejection-stages-of-rat-allograft-liver-transplantation
#14
Yi Zhang, Xiaofei Wang, Liwei Mao, Di Yang, Weiwu Gao, Zhiqiang Tian, Mengjie Zhang, Xia Yang, Kuansheng Ma, Yuzhang Wu, Bing Ni
Interleukin-22 (IL-22) is a recently identified regulator of inflammation, but little is known about its role in liver transplantation. Therefore, in this study, we explored the roles and the underlying mechanisms of IL-22 in acute allograft rejection by using a rat allogeneic liver transplantation model. Results showed that allograft liver transplantation led to damage of the parent liver and to significantly increased IL-22 expression in the allograft liver and plasma of the recipient rats compared with the rats who received isografts...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29369782/pharmacological-inhibitory-profile-of-tak-828f-a-potent-and-selective-orally-available-ror%C3%AE-t-inverse-agonist
#15
Akira Shibata, Keiko Uga, Takayuki Sato, Masaki Sagara, Keiko Igaki, Yoshiki Nakamura, Atsuko Ochida, Mitsunori Kono, Junya Shirai, Satoshi Yamamoto, Masashi Yamasaki, Noboru Tsuchimori
Retinoic acid-related orphan receptor γt (RORγt) is a key master regulator of the differentiation and activation of IL-17 producing CD4+ Th17, CD8+ Tc17 and IL-17/IFN-γ co-producing cells (Th1/17 cells). These cells play critical roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease and multiple sclerosis. Thus, RORγt is an attractive target for the treatment of these diseases. We discovered TAK-828F, an orally available potent and selective RORγt inverse agonist. The inhibitory effect on the activation and differentiation of Th17 cells by TAK-828F was evaluated in mouse and human primary cells...
January 21, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29364878/innate-and-adaptive-lymphocytes-sequentially-shape-the-gut-microbiota-and-lipid-metabolism
#16
Kairui Mao, Antonio P Baptista, Samira Tamoutounour, Lenan Zhuang, Nicolas Bouladoux, Andrew J Martins, Yuefeng Huang, Michael Y Gerner, Yasmine Belkaid, Ronald N Germain
The mammalian gut is colonized by numerous microorganisms collectively termed the microbiota, which have a mutually beneficial relationship with their host. Normally, the gut microbiota matures during ontogeny to a state of balanced commensalism marked by the absence of adverse inflammation. Subsets of innate lymphoid cells (ILCs) and conventional T cells are considered to have redundant functions in containment and clearance of microbial pathogens, but how these two major lymphoid-cell populations each contribute to shaping the mature commensal microbiome and help to maintain tissue homeostasis has not been determined...
February 8, 2018: Nature
https://www.readbyqxmd.com/read/29361119/imaging-fibroblast-activation-protein-to-monitor-therapeutic-effects-of-neutralizing-interleukin-22-in-collagen-induced-arthritis
#17
Tessa van der Geest, Debbie M Roeleveld, Birgitte Walgreen, Monique M Helsen, Tapan K Nayak, Christian Klein, Martin Hegen, Gert Storm, Josbert M Metselaar, Wim B van den Berg, Peter M van der Kraan, Peter Laverman, Otto C Boerman, Marije I Koenders
Objectives: RA is a chronic autoimmune disease leading to progressive destruction of cartilage and bone. RA patients show elevated IL-22 levels and the amount of IL-22-producing Th cells positively correlates with the extent of erosive disease, suggesting a role for this cytokine in RA pathogenesis. The purpose of this study was to determine the feasibility of SPECT/CT imaging with 111In-labelled anti-fibroblast activation protein antibody (28H1) to monitor the therapeutic effect of neutralizing IL-22 in experimental arthritis...
January 18, 2018: Rheumatology
https://www.readbyqxmd.com/read/29353025/efficacy-and-safety-of-fezakinumab-an-anti-il-22-monoclonal-antibody-in-adults-with-moderate-to-severe-atopic-dermatitis-inadequately-controlled-by-conventional-treatments-a-randomized-double-blind-phase-2a-trial
#18
Emma Guttman-Yassky, Patrick M Brunner, Avidan U Neumann, Saakshi Khattri, Ana B Pavel, Kunal Malik, Giselle K Singer, Danielle Baum, Patricia Gilleaudeau, Mary Sullivan-Whalen, Sharon Rose, Shelbi Jim On, Xuan Li, Judilyn Fuentes-Duculan, Yeriel Estrada, Sandra Garcet, Claudia Traidl-Hoffmann, James G Krueger, Mark G Lebwohl
BACKGROUND: IL-22 promotes epidermal hyperplasia and inhibits skin barrier function. OBJECTIVE: Evaluate IL-22 blockade in adults with moderate-to-severe atopic dermatitis (AD). METHODS: Randomized, double-blind, placebo-controlled trial with intravenous fezakinumab monotherapy every 2wks for 10wks, with follow-up assessments until 20wks. SCORAD change from baseline at 12wks served as primary endpoint. RESULTS: At 12wks, mean SCORAD decline was 13·8±2·7 (fezakinumab) vs...
January 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29345621/the-circulating-t-helper-subsets-and-regulatory-t-cells-in-patients-with-common-variable-immunodeficiency-with-no-known-monogenic-disease
#19
G Azizi, A Mirshafiey, H Abolhassani, R Yazdani, F J Ansariha, M Shaghaghi, S S Mortazavi-Jahromi, F Noorbakhsh, N Rezaei, A Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency (PID), characterized by heterogeneous clinical manifestations and defects in B- and T- cells. In the present study, we investigated the T helper (Th) cell subsets and regulatory T (Treg) cells, and their related cytokines and transcription factors in the CVID patients with no definite genetic diagnosis. METHODS: The study population comprised 13 CVID patients and 13 healthy controls (HC)...
January 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29344110/anti-interleukin-and-interleukin-therapies-for-psoriasis-current-evidence-and-clinical-usefulness
#20
REVIEW
Ya-Chu Tsai, Tsen-Fang Tsai
Anti-interleukin (IL) therapies have emerged as a major treatment for patients with moderate-to-severe psoriasis. This article reviews the up-to-date results of pivotal clinical trials targeting the interleukins used for the treatment of psoriasis, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, IL-20, IL-22, IL-23, IL-36 and bispecific biologics IL-17A/tumor necrosis factor alpha (TNF-α). Cytokines involved in the circuits of psoriasis inflammation without ongoing clinical trials are also mentioned (IL-9, IL-13, IL-15, IL-16, IL-18, IL-19, IL-21, IL-24, IL-27, IL-33, IL-35, IL-37, and IL-38)...
November 2017: Therapeutic Advances in Musculoskeletal Disease
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