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María Pilar Ruiz-Del-Tiempo, Pilar Calvo, Antonio Ferreras, Jesús Leciñena, Luis Pablo, Oscar Ruiz-Moreno
Purpose: To evaluate anatomical retinal changes measured by spectral-domain optical coherence tomography (SD-OCT), after applying photodynamic therapy (PDT) for treatment of chronic central serous chorioretinopathy (CSC). Methods: A retrospective analysis was conducted on 43 patients (48 eyes) with chronic CSC treated with PDT. Visual acuity (VA), central retinal thickness (CRT), outer nuclear layer (ONL) thickness, subretinal fluid (SRF), and photoreceptor ellipsoid zone (EZ) measured by SD-OCT were collected at baseline and at 3, 6, and 12 months after PDT...
2018: Journal of Ophthalmology
M Waseem Akram, Muhammad Fakhar-E-Alam, M Atif, Alvina Rafique Butt, Ali Asghar, Yasir Jamil, K S Alimgeer, Zhiming M Wang
MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique...
March 15, 2018: Scientific Reports
Pawel Posadzki, Josip Car
Clinical Question: Are light therapies effective and safe for treating acne? Bottom Line: The evidence for all light therapies remains weak and inconclusive. Red-light methyl aminolevulinate-photodynamic therapy (MAL-PDT) was the only treatment associated with a small though clinically insignificant reduction in the number of inflamed lesions and in global improvement as assessed by an investigator in moderate to severe acne. Red-light MAL-PDT was not associated with higher rates of severe adverse effects than placebo or no treatment...
March 14, 2018: JAMA Dermatology
Michael Schwake, Andrei Nemes, Jana Dondrop, Juliane Schroeteler, Stephanie Schipmann, Volker Senner, Walter Stummer, Christian Ewelt
BACKGROUND: Light irradiation (635 nm) of cells containing protoporphyrin IX (PPIX) after 5- aminolevulinic acid (5-ALA) pretreatment causes cell death via different pathways including apoptosis and necrosis, as previously demonstrated for malignant glioma cells. OBJECTIVE: To elucidate whether various malignant pediatric brain tumors, which have been shown to accumulate PPIX, would also be susceptible to photodynamic therapy (PDT). METHODS: Medulloblastoma (DAOY, UW228), pNET (PFSK-1), and rhabdoid tumor (BT16) cell lines were incubated with 5-ALA in variable concentrations for 4 h...
March 12, 2018: Neurosurgery
Darika Saitawee, Aroon Teerakapong, Noppawan Phumala Morales, Paiboon Jitprasertwong, Doosadee Hormdee
BACKGROUND AND OBJECTIVE: Curcumin, one of an established curcuminoid substances extracted from Curcuma longa, has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Curcuminoid substances has been reported to have benefits in treating dental chronic infection and inflammation diseases, such as chronic periodontitis. The purpose of this study was to find the optimum concentration of Curcuma longa (CL) extract, containing all curcuminoid substances, and the power density of blue light (BL) in photodynamic therapy against periodontally pathogenic bacteria, A...
March 10, 2018: Photodiagnosis and Photodynamic Therapy
Bunpei Katayama, Toshiyuki Ozawa, Kuniyuki Morimoto, Kunio Awazu, Nobuhisa Ito, Norihiro Honda, Naoki Oiso, Daisuke Tsuruta
BACKGROUND: Pseudomonas aeruginosa (PA) frequently develops antibiotic-resistant characteristics, which is clinically problematic. The main reason behind the rise of antibiotic-resistant PA is the extensive use of antibiotics. Therefore, a novel technique is needed to treat PA infections. Photodynamic therapy (PDT) is thought to have the potential to be a non-antibiotic treatment for infections. 5-Aminolevulinic acid (ALA), which works as a photosensitizer after being metabolized into protoporphyrin IX (PpIX) in the heme synthetic pathway, is used for PDT...
March 5, 2018: Journal of Dermatological Science
Qiuju Wu, Ping Tu, Guoyu Zhou, Huilan Yang, Zhanchao Zhou, Yi Zhao, Qingshan Zheng, Ying Gu, Jining Tao, Xuejun Zhu
BACKGROUND/PURPOSE: Previous studies have shown that hemoporfin-mediated photodynamic therapy (PDT) was a treatment for port-wine stain (PWS). Our current study aimed to identify optimal hemoporfin dose. METHODS: A prospective, multicenter, double-blind, randomized clinical trial was conducted. Patients were assigned into low or high dose hemoporfin (2.5 mg/kg and 5 mg/kg intravenously, respectively), or control (placebo) group, at a rate of 2: 2: 1. Treatment efficacy was evaluated at week 8...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
C C Ude, W T Seet, S Sharen Aini, B S Aminuddin, B H I Ruszymah
The study objectives include, enhancing the proliferations of aged bone marrow stem cells (BMSCs) and adipose stem cells (ADSCs); and evaluating the shelf lives of clinical grade chondrogenically induced cells from both samples. ADSCs and BMSCs from 56 patients (76 ± 8 yrs) were proliferated using basal medium (FD) and at (5, 10, 15, 20 and 25) ng/ml of basal fibroblast growth factor (bFGF). They were induced to chondrogenic lineage and stored for more than 120 hrs in FD, serum, Dulbecco's phosphate buffered saline (DPBS) and saline at 4 °C...
March 12, 2018: Scientific Reports
Juan G Yañuk, M Paula Denofrio, Federico A O Rasse-Suriani, Fernando D Villarruel, Federico Fassetta, Fernando S García Einschlag, Rosa Erra-Balsells, Bernd Epe, Franco M Cabrerizo
Photodynamic therapy (PDT) is an emerging clinical treatment currently being used against a wide range of both cancerous and noncancerous diseases. The search for new active photosensitizers as well as the development of novel selective delivery systems are the major challenges faced in the application of PDT. We investigated herein three chloroharmine derivatives (6-, 8- and 6,8-dichloroharmines) with quite promising intrinsic photochemical tunable properties and their ability to photoinduce DNA damage in order to elucidate the underlying photochemical mechanisms...
March 12, 2018: Organic & Biomolecular Chemistry
Dan Yang, Guixin Yang, Qianqian Sun, Shili Gai, Fei He, Yunlu Dai, Chongna Zhong, Piaoping Yang
The use of visible light to produce reactive oxygen species (ROS) from renewable water splitting is a highly promising means in photodynamic therapy (PDT). Up to date, diverse inorganic-organic hybrid materials developed as photosensitizers still undergo low therapeutic efficiency and/or poor stability. Herein, a kind of carbon-nanodot-decorated TiO2 nanotubes (CDots/TiO2 NTs) composite is developed and applied for photodynamic therapy. Upon 650 nm laser light excitation, the emissions with short wavelengths (325-425 nm) from the CDots as a result of upconversion process excite TiO2 NTs to form electron/hole (e- /h+ ) pairs, triggering the reaction with the adsorbed oxidants to produce ROS...
March 12, 2018: Advanced Healthcare Materials
Imran Rizvi, Girgis Obaid, Shazia Bano, Tayyaba Hasan, David Kessel
OBJECTIVE: A relatively low level of lysosomal photodamage has been shown capable of promoting the efficacy of photodamage simultaneously or subsequently directed to mitochondrial/ER sites. The procedure has hitherto involved the use of two photosensitizing agents that require irradiation at two different wavelengths and different formulation techniques. This, together with different pharmacokinetic profiles of the photosensitizers, adds a layer of complexity to a protocol that we have sought to circumvent...
March 11, 2018: Lasers in Surgery and Medicine
Yu Cheng, Xiaoxiao Tan, Jinping Wang, Yidan Wang, Yilin Song, Qing You, Qi Sun, Li Liu, Siyu Wang, Fengping Tan, Jiao Li, Nan Li
Recently, ultrasmall gadolinium oxide (Gd2 O3 ) nanoparticles with high longitudinal relaxation rate have received enormous attention. However, it can't be concentrated in tumor site through intravenous administration due to its ultrasmall size. In this project, we coated ultrasmall Gd2 O3 nanoparticles with a near-infrared (NIR) light-absorbing polymer polypyrrole (PPy), modifying with hyaluronic acid (HA) and loaded aluminum phthalocyanine (AlPc), the Gd2 O3 @PPy/AlPc-HA nanoparticles could be used for fluorescence (FL)/magnetic resonance (MR)/photoacoustic (PA) imaging guided as well as remotely controlled PTT/PDT combined anti-tumor therapy...
March 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jihwan Son, Seung Mok Yang, Gawon Yi, Yoon Jin Roh, Hyeji Park, Jae Myung Park, Myung-Gyu Choi, Heebeom Koo
Targeted drug delivery has been an important issue for tumor therapy including photodynamic therapy (PDT). The purpose of our study is to increase the targeting efficiency of photosensitizer (PS) using folate-modified nanoparticles (NPs) to tumor site in vivo. Folate receptor is over-expressed on the surface of many human cancer cells. We prepared poly (lactic-co-glycolic acid) (PLGA) NPs containing pheophorbide a (Pba), a PS that is used in PDT and generates free radical for killing cancer cells. The surface of NPs was composed of phospholipids modified with polyethylene glycol (PEG) and folate (FA)...
March 5, 2018: Biochemical and Biophysical Research Communications
Bernhard Strauß, Uwe Altmann, Susanne Manes, Anne Tholl, Susan Koranyi, Tobias Nolte, Manfred E Beutel, Jörg Wiltink, Stephan Herpertz, Wolfgang Hiller, Jürgen Hoyer, Peter Joraschky, Björn Nolting, Viktoria Ritter, Ulrich Stangier, Ulrike Willutzki, Simone Salzer, Eric Leibing, Falk Leichsenring, Helmut Kirchmann
OBJECTIVES: Within a randomized controlled trial contrasting the outcome of manualized cognitive-behavioral (CBT) and short term psychodynamic therapy (PDT) compared to a waiting list condition (the SOPHO-Net trial), we set out to test whether self-reported attachment characteristics change during the treatments and if these changes differ between treatments. RESEARCH DESIGN AND METHODS: 495 patients from the SOPHO-Net trial (54.5% female, mean age 35.2 years) who were randomized to either CBT, PDT or waiting list (WL) completed the partner-related revised Experiences in Close Relationships Questionnaire (ECR-R) before and after treatment and at 6 and 12 months follow-up...
2018: PloS One
Sungsoon Hwang, Se Woong Kang, Sang Jin Kim, Jun Won Jang, Kyung Tae Kim
PURPOSE: To report the clinical outcomes of reduced-fluence photodynamic therapy (PDT) for symptomatic subfoveal retinal pigment epithelial detachment (RPED) in central serous chorioretinopathy and identify prognostic factors affecting treatment outcome. METHODS: This retrospective interventional study included 35 eyes of 35 patients with serous subfoveal RPED with choroidal hyperpermeability. Cases with evidence of age-related macular degeneration were excluded from the study...
March 5, 2018: Retina
Xin Yu, Heyi Zheng
Condyloma acuminatum (CA), or genital wart, is a sexually transmitted infection caused by human papillomaviruses. Increasing evidences demonstrated that photodynamic therapy (PDT) is effective in eliminating latent HPV infection, the major reason for CA recurrence. We observed an increasing number of infections after PDT in CA patients, which has not been reported before. This study aims to evaluate the incidence and management of infection in CA patients after PDT procedure. CA patients received PDT from January 2015 to February 2016 at the outpatient setting...
March 7, 2018: Environmental Science and Pollution Research International
Daiki Antoku, Shuhei Satake, Tomoya Mae, Kouta Sugikawa, Hisakage Funabashi, Akio Kuroda, Atsushi Ikeda
The weak absorbance of pristine C₆₀, C₇₀, and fullerene derivatives at wavelengths over 600 nm hampers the use of these molecules as photosensitizers (PSs) for photodynamic therapy (PDT). The coexistence of light-harvesting antenna molecules with a fullerene derivative in lipid membrane bilayers solved this issue. By controlling the location of the C₆₀ derivative in the lipid membrane, the liposomal dyad system for PDT improved the photodynamic activity via an efficient photoenergy transfer from antenna molecules to the fullerene derivative...
March 7, 2018: Chemistry: a European Journal
Mladen Korbelik
The insult delivered by photodynamic therapy (PDT) in treated cells is oxidative stress. The main burden threatening survival of PDT-treated cells is proteotoxic damage that jeopardizes proteostasis in these cells. For dealing with this type of proteostasis impairment, cells have developed protection mechanisms operating by signaling networks. This review will outline various components of signaling networks that can be engaged in stressed cells with highlighting the emerging aspects relevant to response to PDT...
March 7, 2018: Lasers in Surgery and Medicine
Haixia Zhang, Kuangpeng Liu, Zhixiao Xue, Huijuan Yin, Huajiang Dong, Wendong Jin, Xiafei Shi, Han Wang, Hai Wang
This study evaluated the effects and mechanism of action of combining irreversible electroporation (IRE) and photodynamic therapy (PDT) in breast cancer cells in vitro and in vivo . Jin's formula was used to assess killing efficacy of different IRE+PDT dosing combinations in breast cancer MCF-7 cells. Flow cytometry, high-content imaging, and confocal laser scanning microscopy were used to detect apoptosis. qRT-PCR and western blotting were used to evaluate expression of apoptosis-related genes and proteins...
2018: American Journal of Translational Research
Aleksandra Kawczyk-Krupka, Zenon Czuba, Wojciech Latos, Katarzyna Wasilewska, Thomas Verwanger, Barbara Krammer, Aleksander Sieroń
BACKGROUND: Photodynamic therapy has apart from a direct cytotoxic effect also immunomodulatory properties. The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. METHODS: We used two human colon cancer cell lines SW480 and SW620 of different malignancies which were treated with a sublethal PDT protocol. Determination of interleukins was carried out using the Bio- Plex Assay Pro™ kit on the Bio- Plex Suspension Array System...
March 3, 2018: Photodiagnosis and Photodynamic Therapy
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