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https://www.readbyqxmd.com/read/28737393/continuous-o2-evolving-mnfe2o4-nanoparticle-anchored-mesoporous-silica-nanoparticles-for-efficient-photodynamic-therapy-in-hypoxic-cancer
#1
Jonghoon Kim, Hye Rim Cho, Hyejin Jeon, Dokyoon Kim, Changyeong Song, Nohyun Lee, Seung Hong Choi, Taeghwan Hyeon
Cancer hypoxia, which involves a complex microenvironment ex-hibiting low O2 concentrations and nutrient deficiency, is known to prevent effective cancer treatment. In particular, the therapeutic effects of photodynamic therapy (PDT) are severely limited by cancer hypoxia, because the PDT process is strongly dependent on O2 concentration. Herein, we design and synthesize biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nano-particles (MFMSNs) to overcome hypoxia, and consequently en-hancing the therapeutic efficiency of PDT...
July 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28737290/integration-of-ir-808-sensitized-upconversion-nanostructure-and-mos2-nanosheet-for-808-nm-nir-light-triggered-phototherapy-and-bioimaging
#2
Jiating Xu, Arif Gulzar, Yuhui Liu, Huiting Bi, Shili Gai, Bin Liu, Dan Yang, Fei He, Piaoping Yang
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR-excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR-808 dye sensitized upconversion nanoparticle (UCNP) with a chlorin e6 (Ce6)-functionalized silica layer is developed for PDT agent. The two booster effectors (dye-sensitization and core-shell enhancement) synergistically amplify the upconversion efficiency, therefore achieving superbright visible emission under low 808 nm light excitation...
July 24, 2017: Small
https://www.readbyqxmd.com/read/28735175/cancer-cell-membrane-coated-biomimetic-platform-for-tumor-targeted-photodynamic-therapy-and-hypoxia-amplified-bioreductive-therapy
#3
Shi-Ying Li, Hong Cheng, Wen-Xiu Qiu, Lu Zhang, Shuang-Shuang Wan, Jing-Yue Zeng, Xian-Zheng Zhang
Modulating tumor microenvironment to amplify the therapeutic efficiency would be a novel strategy for effective cancer treatment. In this work, based on the TPZ-loaded porphyrinic metal organic framework PCN-224 (PCN stands for porous coordination network), a cancer cell membrane-coated nanoplatform (TPZ@PCN@Mem) was fabricated for tumor targeted PDT and the successively resulting hypoxia-amplified bioreductive therapy. After administration, TPZ@PCN@Mem exhibited the selective accumulation and long-term retention at tumor tissue due to the immune escape and homologous targeting endowed by the cancer membrane coating...
July 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28729656/endolysosomal-targeting-of-a-clinical-chlorin-photosensitiser-for-light-triggered-delivery-of-nano-sized-medicines
#4
Elnaz Yaghini, Ruggero Dondi, Kunal M Tewari, Marilena Loizidou, Ian M Eggleston, Alexander J MacRobert
A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemical internalisation (PCI) is a technique for inducing cytosolic release of the entrapped agents that harnesses sub-lethal photodynamic therapy (PDT) using a photosensitiser that localises in endolysosomal membranes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28726936/dithiolato-and-halogenido-bridged-nickel-iron-complexes-related-to-the-active-site-of-nife-h2ases-preparation-structures-and-electrocatalytic-h2-production
#5
Li-Cheng Song, Xiao-Feng Han, Wei Chen, Jia-Peng Li, Xu-Yong Wang
A new series of the structural and functional models for the active site of [NiFe]-H2ases has been prepared by a simple and convenient synthetic route. Thus, treatment of diphosphines RN(PPh2)2 (1a, R = p-MeC6H4CH2; 1b, R = EtO2CCH2) with an equimolar NiCl2·6H2O, NiBr2·3H2O, and NiI2 in refluxing CH2Cl2/MeOH or EtOH gave the mononuclear Ni complexes RN(PPh2)2NiX2 (2a, R = p-MeC6H4CH2, X = Cl; 2b, R = EtO2CCH2, X = Cl; 3a, R = p-MeC6H4CH2, X = Br; 3b, R = EtO2CCH2, X = Br; 4a, R = p-MeC6H4CH2, X = I; 4b, R = EtO2CCH2, X = I) in 67-97% yields...
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28726387/aryl-substituted-ruthenium-ii-complexes-a-strategy-for-enhanced-photocleavage-and-efficient-dna-binding
#6
Felipe Diógenes Abreu, Tercio de F Paulo, Marcelo H Gehlen, Rômulo A Ando, Luiz G F Lopes, Ana Cláudia S Gondim, Mayron A Vasconcelos, Edson H Teixeira, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and great reactive oxygen species (ROS) photogeneration: two properties that are not easily found in the same molecule. To prepare such new agents, we synthesized two new ruthenium complexes that combine an efficient DNA binding moiety (dppz ligand) together with naphthyl-modified (1) and anthracenyl-modified (2) bipyridine as a strong ROS generator bound to a ruthenium complex...
July 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28725533/controllable-photodynamic-therapy-implemented-by-regulating-singlet-oxygen-efficiency
#7
REVIEW
Wenting Wu, Xiaodong Shao, Jianzhang Zhao, Mingbo Wu
With singlet oxygen ((1)O2) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28722754/-31-p-nmr-evidence-for-peroxide-intermediates-in-lipid-emulsion-photooxidations-phosphine-substituent-effects-in-trapping
#8
Prabhu P Mohapatra, Callistus O Chiemezie, Arina Kligman, Michele M Kim, Theresa M Busch, Timothy C Zhu, Alexander Greer
Intralipid is a lipid emulsion used in photodynamic therapy (PDT) for its light scattering and tissue-simulating properties. The purpose of this study is to determine whether or not Intralipid undergoes photooxidation, we have carried out an Intralipid peroxide trapping study using a series of phosphines [2'-dicyclohexylphosphino-2,6-dimethoxy-1,1'-biphenyl-3-sulfonate, 3-(diphenylphosphino)benzenesulfonate, triphenylphosphine-3,3',3''-trisulfonate, and triphenylphosphine]. Our new findings are as follows: (i) An oxygen atom is transferred from Intralipid peroxide to the phosphine traps in the dark, after the photooxidation of Intralipid...
July 19, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#9
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#10
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28715120/characterization-of-a-multiple-particle-delivery-complex-and-determination-of-cellular-photodamage-in-skin-fibroblast-and-breast-cancer-cell-lines
#11
Ivan Mfouo-Tynga, Nicolette Nadene Houreld, Heidi Abrahamse
Zinc metallized Phthalocyanine (ZnPcSmix ), a potent photosensitizer (PS), is conjugated to gold dendrimer encapsulated nanoparticles (AuDENPs) in order to improve the efficacy of Photodynamic therapy (PDT) using MCF-7 breast cancer cells and WS1 fibroblast cells as a control. Both ZnPcSmix and AuDENPs are mixed in a nitrogen atmosphere for 48 h and characterization analysis conducted using ultra violet visible (UV-vis) spectrometry for spectral properties, transmission electron microscopy (TEM) for morphological features and zeta potential measurement for surface stability and size distribution of the compound obtained or of the multiple particles delivery complex (MPDC)...
July 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28715096/effect-of-avulsion-storage-media-on-periodontal-ligament-fibroblast-differentiation
#12
İrem Bağ, Sibel Yildirim
BACKGROUND/AIM: An avulsed tooth must be stored in a solution which maintains periodontal ligament (PDL) cell viability. The aim of this study was to compare the effects of Hank's Balanced Salt Solution (HBSS) and milk on the differentiation of PDL fibroblasts. MATERIAL AND METHODS: Eighteen extracted third molars, (n = 3 for each group), were immersed in HBSS, milk, and Dulbecco's Modified Eagle Medium-Ham's F12 (DMEM-F12) at 4 °C for 30-60 min or 12 h. The growth dynamics of PDL fibroblasts were evaluated with cell proliferation graphics and population doubling time (PDT) values...
July 17, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28713709/high-quality-of-infant-chondrocytes-in-comparison-with-adult-chondrocytes-for-cartilage-tissue-engineering
#13
Fatemeh Mortazavi, Hajar Shafaei, Jafar Soleimani Rad, Leila Rushangar, Azadeh Montaceri, Masoud Jamshidi
BACKGROUND: Tissue engineering is used for the treatment of many diseases, and the ideal cell source for cartilage tissue engineering is chondrocytes. The main limitation of chondrocyte is the low number of cells in cartilage tissue engineering. This study investigated a suitable cell source with high proliferation rate to obtain a large number of chondrocytes. METHODS: Adult cartilage tissue samples were obtained from adult patients undergoing surgical procedure, and infant cartilage tissue samples were obtained from polydactyly surgical waste...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713674/intraoperative-adjuncts-for-malignant-pleural-mesothelioma
#14
REVIEW
Warren Ho Chan, David J Sugarbaker, Bryan M Burt
Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, heated intraoperative PVP-I, and PDT, this aims to provide an update on some of the most promising intraoperative adjuncts for patients with MPM...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28710659/comparison-of-the-effect-of-skin-preparation-pads-on-transepidermal-water-loss-in-ex-vivo-human-skin
#15
Hanan Osman-Ponchet, Alexandre Gaborit, Magali Kouidhi, Sandrine Anglars, Jeanne Marceau-Suissa, Orla Duffy-Roger, Jean-Michel Linget, Claire E Wilson
INTRODUCTION: Pre-treatment of the skin to remove scales and crusts prior to photodynamic therapy (PDT) is essential to enhance the uptake of topically applied methyl aminolevulinate (MAL) and to improve treatment efficacy. This study compared the effect of two different skin preparation pads on skin integrity in ex vivo human skin. METHODS: Ex vivo human skin samples from three donors were pre-treated in triplicates with PREPSTER™ (PR) skin preparation pad (6, 8, and 10 passages) or Ambu Unilect™ (A-UN) skin preparation pad (6, 8, and 10 passages)...
July 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28709135/inhibition-of-lymphangiogenesis-impairs-antitumour-effects-of-photodynamic-therapy-and-checkpoint-inhibitors-in-mice
#16
Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W Kilarski, Louis Boon, Tomasz J Klaus, Jakub Golab
Photodynamic therapy (PDT) has been shown to destroy tumour-associated lymphatic vessels. Therefore, we sought to investigate the functional outcomes of PDT-mediated damage to the lymphatic vessels. We observed that PDT with verteporfin, completely but transiently, blocks the functional lymphatic drainage in the orthotopic mammary tumour models. Sustained inhibition of lymphatic vessels regeneration induced by lenalidomide or the soluble form of vascular endothelial growth factor receptor 3 (sVEGFR3) that neutralises lymphangiogenic vascular endothelial growth factor C (VEGF-C), significantly impaired antitumour efficacy of PDT...
July 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28708389/nanostructured-phthalocyanine-assemblies-with-protein-driven-switchable-photoactivities-for-biophotonic-imaging-and-therapy
#17
Xingshu Li, C-Yoon Kim, Seunghyun Lee, Dayoung Lee, Hyung Min Chung, Gyoungmi Kim, Si-Hyun Heo, Chulhong Kim, Ki-Sung Hong, Juyoung Yoon
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible and versatile phthalocyanine building blocks. The nanostructured phthalocyanine assemblies (NanoPcTBs) display intrinsically unique photothermal and photoacoustic properties. Fluorescence and reactive oxygen species (ROS) generation can be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT)...
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28705551/effects-of-progressive-resistance-training-on-cardiovascular-autonomic-regulation-in-patients-with-parkinson-s-disease-a-randomized-controlled-trial
#18
Hélcio Kanegusuku, Carla Silva-Batista, Tiago Peçanha, Alice Nieuwboer, Natan D Silva, Luiz A R Costa, Marco T de Mello, Maria E P Piemonte, Carlos Ugrinowitsch, Cláudia L M Forjaz
OBJECTIVE: To evaluate the effects of a progressive resistance training (RT) on cardiac autonomic modulation and on cardiovascular responses to autonomic stress tests in patients with Parkinson disease (PD). DESIGN: Randomized clinical trial. SETTING: The Brazilian Parkinson Association. PARTICIPANTS: 30 patients with PD (modified Hoehn and Yahr stages 2-3) were randomly divided into 2 groups: a progressive RT group (PDT) and a control group (PDC)...
July 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28703320/5-aminolevulinic-acid-patch-pdt-in-the-treatment-of-actinic-cheilitis
#19
Sonja Radakovic, Adrian Tanew
BACKGROUND: Actinic cheilitis (AC) is a common disease caused by chronic ultraviolet exposure. OBJECTIVE: Alacare is a self-adhesive, skin coloured 5-aminolaevulinic acid (ALA) patch that has been developed for the treatment of mild to moderate actinic keratosis (AK). Considering the good results in the treatment of AK, the standardized delivery of ALA and the simple application Alacare patch PDT appears as an interesting treatment option for AC. METHODS: We retrospectively assessed the efficacy, tolerability and cosmetic outcome of Alacare patch PDT in eleven patients with AC...
July 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28702557/synthesis-characterization-and-in-vitro-and-in-vivo-photodynamic-activities-of-a-gallium-iii-tris-ethoxycarbonyl-corrole
#20
Zhao Zhang, Hua-Hua Wang, Hua-Jun Yu, Yu-Zhen Xiong, Hai-Tao Zhang, Liang-Nian Ji, Hai-Yang Liu
Corroles have been previously demonstrated to be a new and promising photosensitizer (PS) in photodynamic therapy (PDT) for cancer cells. This research reported the preparation of an electron-deficient flat gallium(iii) tris(ethoxycarbonyl)corrole (1-Ga). Its in vitro PDT activities towards different cancer cell lines were examined, and the best PDT activity was observed in A549 cell lines. 1-Ga could penetrate the cell membrane rapidly and exhibit remarkable photo-cytotoxicity. 1-Ga can induce A549 cell apoptosis via ROS-mediated mitochondrial pathways, in which p38 and sirt-1 proteins play a key role...
July 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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