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https://www.readbyqxmd.com/read/29453540/cellular-and-molecular-toxicity-of-iron-oxide-nanoparticles
#1
Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro, Vanessa Valdiglesias
Iron oxide nanoparticles (ION) have attracted much attention because of their particular physico-chemical properties, including superparamagnetism. These features make them suitable for many purposes and several interesting biomedical applications, such as to increase contrast in magnetic resonance imaging (MRI), as drug delivery systems and as hyperthermia agents. However, they have also shown to be easily accumulated in diverse tissues and induce toxicity at different levels. This chapter reviews the different cellular and molecular effects induced by ION reported from in vitro studies with human and non-human cell lines...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29450799/iron-oxide-labeling-does-not-affect-differentiation-potential-of-human-bone-marrow-mesenchymal-stem-cells-exhibited-by-their-differentiation-into-cardiac-and-neuronal-cells
#2
Sujata Mohanty, Krishan Gopal Jain, Sushmita Bose Nandy, Anupama Kakkar, Manoj Kumar, Amit Kumar Dinda, Harpal Singh, Alok Ray
Mesenchymal stem cells (MSCs) have shown promising outcomes in cardiac and neuronal diseases. Efficient and noninvasive tracking of MSCs is essential to harness their therapeutic potential. Iron oxide nanoparticles (IONPs) have emerged as effective means to label stem cells and visualize them using magnetic resonance imaging (MRI). It is known that IONPs do not affect viability and cell proliferation of stem cells. However, very few studies have demonstrated differentiation potential of iron oxide-labeled MSCs and their differentiation into specific lineages that can contribute to cellular therapies...
February 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29450605/abbreviated-mpmri-protocol-for-diffuse-liver-disease-a-practical-approach-for-evaluation-and-follow-up-of-nafld
#3
Guilherme Moura Cunha, Cristiane A Villela-Nogueira, Anke Bergman, Flavia Paiva Proença Lobo Lopes
AIM: Multiparametric magnetic resonance imaging (mpMRI) may help determine the metabolic profile of patients with obesity and metabolic syndrome in addition to their clinical and laboratory biomarkers for diagnosis and monitoring. An abbreviated mpMRI protocol may be a faster, less-costly, and easier to perform alternative for the diagnosis, treatment, and follow-up of patients with NAFLD and for use in clinical trials. OBJECTIVE: To evaluate an abbreviated mpMRI protocol tailored to analyze quantitative imaging features of patients with obesity and NAFLD and assess its use during treatment...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29448602/preparation-of-silica-coated-magnetic-nanoparticles-for-bioseparation
#4
Dae-Won Lee, Hira Fatima, Kyo-Seon Kim
Magnetic nanoparticles have been intensively developed and applied in several biomedical applications such as targeted delivery, drug therapy, hyperthermia, magnetic resonance imaging and bioseparation etc. This work describes a simple and convenient method to synthesize silica coated Fe3O4 nanoparticles which have the potential to be used in the bioseparation of fetuin from fetal bovine serum and albumin from the egg. In this work, uniform Fe3O4 particles were prepared through the one-pot solvothermal process at 200 °C for 12 h using a sole iron precursor (FeCl3 · 6H2O) and then were coated with SiO2 to prepare silica coated Fe3O4 nanoparticles by hydrolysis and condensation of tetraethyl orthosilicate in ethanol and H2O medium...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29438105/magnetic-resonance-and-photoacoustic-imaging-of-brain-tumor-mediated-by-mesenchymal-stem-cell-labeled-with-multifunctional-nanoparticle-introduced-via-carotid-artery-injection
#5
Yang Qiao, Joy Gumin, Christopher MacLellan, Feng Gao, Richard Bouchard, Frederick Lang, R Jason Stafford, Marites P Melancon
To evaluate the feasibility of visualizing bone marrow-derived human mesenchymal stem cells (MSCs) labeled with a gold-coated magnetic resonance (MR)-active multifunctional nanoparticle (SPIO@Au) for assessing the extent of MSC homing in glioma- bearing mice following carotid artery MSC injection. MATERIALS AND METHODS: Nanoparticle containing superparamagnetic iron oxide coated with gold (SPIO@Au) having a diameter of ~82 nm and maximum absorbance in the near infrared (NIR) region was synthesized...
February 13, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29433060/dual-tumor-targeted-multifunctional-magnetic-hyaluronic-acid-micelles-for-enhanced-mr-imaging-and-combined-photothermal-chemotherapy
#6
Shaohui Zheng, Jiwon Han, Zhen Jin, Chang-Sei Kim, Sukho Park, Kyu-Pyo Kim, Jong-Oh Park, Eunpyo Choi
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29427184/polyneuropathy-and-myopathy-in-beta-thalassemia-major-patients
#7
P Nemtsas, M Arnaoutoglou, V Perifanis, E Koutsouraki, G Spanos, N Arnaoutoglou, P Chalkia, D Pantelidou, A Orologas
The thalassemias are the most common single gene disorder in the world. Nowadays, the average life expectancy of patients in developed countries has increased significantly, while, there was an increase of complications. We aimed to investigate peripheral neuropathy and myopathy in this patient group using a neurophysiological study. We performed nerve conduction studies and electromyography of upper and lower extremities on 36 beta-thalassemia major (β-thal) patients. The electrophysiological findings were correlated with demographic data and laboratory parameters of the disease...
February 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29423465/dually-responsive-gold-iron-oxide-heterodimers-merging-stimuli-responsive-surface-properties-with-intrinsic-inorganic-material-features
#8
Hamilton Kakwere, Maria Elena Materia, Alberto Curcio, Mirko Prato, Ayyappan Sathya, Simone Nitti, Teresa Pellegrino
We demonstrate a versatile approach for the preparation of dually responsive smart inorganic heterostructures (HSs) with the potential for exploitation in nanomedicine. We utilize Au-FexOy dimers as templates for generating smart inorganic HSs with a pH-responsive coating and a thermo-responsive coating attached to iron oxide and gold nanoparticles (NPs), respectively. First, a thiol-modified thermo-responsive (PNIPAAM-co-PEGA) polymer could be selectively attached to the gold domain by ligand exchange. The sequential attachment of a catechol-modified initiator to the iron oxide surface enables the in situ polymerization of a pH-responsive (PDMAEA) polymer...
February 9, 2018: Nanoscale
https://www.readbyqxmd.com/read/29404229/clinical-implications-of-a-novel-iron-containing-fiducial-marker-in-radiotherapy-for-liver-tumors-an-initial-experience
#9
Hiroshi Doi, Shogo Harui, Hiroki Nakajima, Akira Ando, Keiji Kamino, Masayuki Fujiwara, Takayoshi Nakajima, Shinichi Ikura, Tsukasa Aihara, Naoki Yamanaka
A 0.5%-iron-containing fiducial marker, Gold AnchorTM (Naslund Medical AB, Huddinge, Sweden), has been recently developed. Herein, we report our initial experiences with the clinical use of the Gold AnchorTM (GA) in radiotherapy for liver tumors. Data of four consecutive patients with liver tumors, including two liver metastases and two hepatocellular carcinomas, were retrospectively analyzed. The GA was percutaneously placed under local anesthesia, close to the tumor. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (MRI) was performed after the placement of the GA...
December 1, 2017: Curēus
https://www.readbyqxmd.com/read/29399871/the-correlation-between-cardiac-magnetic-resonance-t2-and-left-ventricular-global-longitudinal-strain-in-people-with-%C3%AE-thalassemia
#10
Mozhgan Parsaee, Nehzat Akiash, Azita Azarkeivan, Zahra Alizadeh Sani, Ahmad Amin, Mahboubeh Pazoki, Niloufar Samiei, Mohammad Ali Jalili, Mohammad Hassan Adel, Nahid Rezaian
BACKGROUND: Heart failure is the biggest cause of mortality and morbidity in people with thalassemia, and iron deposition in cardiac tissue impairs cardiovascular function. Therefore, early detection of cardiac involvement is important to improve the prognosis in these individuals. METHOD: Two- and three-dimensional echocardiography was performed to evaluate left ventricular ejection fraction (LVEF), left ventricular volumes and diameters, and global longitudinal strain (GLS) in 130 individuals with β-thalassemia using the speckle tracking method...
February 4, 2018: Echocardiography
https://www.readbyqxmd.com/read/29391212/assessing-the-selective-therapeutic-efficacy-of-superparamagnetic-erlotinib-nanoparticles-in-lung-cancer-by-using-quantitative-magnetic-resonance-imaging-and-a-nuclear-factor-kappa-b-reporter-gene-system
#11
Fei-Ting Hsu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Ping-Huei Tsai, Yu-Chieh Kao, Chia-Feng Lu, Hsu-Shan Huang, Cheng-Yu Chen
Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are commonly used as the first-line treatment for advanced NSCLC; however, the efficacy of drug delivery remains unknown. Hence, we successfully developed erlotinib-conjugated iron oxide nanoparticles (FeDC-E NPs) as theranostic probe that can potentially provide a new avenue for monitoring drug delivering through noninvasive magnetic resonance imaging. MRI ΔR2* relaxivity measurements offer an opportunity to quantitatively evaluate the uptake of FeDC-E NPs at cellular and tumoral levels...
January 29, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29389007/eumelanin-fe3o4-hybrid-nanoparticles-for-enhanced-mr-pa-imaging-assisted-local-photothermolysis
#12
Junqing Wang, Heng Liu, Yu Liu, Chengchao Chu, Youyuan Yang, Yun Zeng, Weiguo Zhang, Gang Liu
In this work, we report on biodegradable eumelanin-Fe3O4 hybrid nanoparticles (euMel-Fe3O4 NPs) for multiple imaging-assisted local photothermolysis. The euMel-Fe3O4 NPs are rationally prepared via a facile one-step co-precipitation method in the aqueous phase in the presence of eumelanin. The obtained NPs exhibited high stability and aqueous dispersity. euMel-Fe3O4 NPs could provide T2-weighted magnetic resonance (MR) and photoacoustic (PA) imaging contrast enhancement prior to the treatment, due to their high r2 relaxivity that was determined to be 245...
February 1, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29384977/improvement-of-chronic-hepatitis-b-by-iron-chelation-therapy-in-a-patient-with-iron-overload-a-case-report
#13
Dong-Mei Zou, Dong-Dong Rong, Hong Zhao, Li Su, Wan-Ling Sun
RATIONALE: This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB. PATIENT CONCERNS: Increased serum ferritin level for 2 months. DIAGNOSIS: Secondary iron overload and CHB. INTERVENTION: To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384731/real-time-volumetric-relative-dosimetry-for-magnetic-resonance-image-guided-radiation-therapy-mr-igrt
#14
Hannah Jungeun Lee, Mo Kadbi, Gary Bosco, Geoffrey S Ibbott
The integration of magnetic resonance imaging (MRI) with linear accelerators (linac) has enabled the use of 3D MR-visible gel dosimeters for real-time verification of volumetric dose distributions. Several iron-based radiochromic 3D gels were created in-house then imaged and irradiated in a pre-clinical 1.5 T - 7 MV MR-Linac. MR images were acquired using a range of balanced-fast field echo (b-FFE) sequences during irradiation to assess the contrast and dose response in irradiated regions and to minimize the presence of MR artifacts...
January 31, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29382055/early-life-iron-deficiency-reduces-brain-iron-content-and-alters-brain-tissue-composition-despite-iron-repletion-a-neuroimaging-assessment
#15
Austin T Mudd, Joanne E Fil, Laura C Knight, Fan Lam, Zhi-Pei Liang, Ryan N Dilger
Early-life iron deficiency has lifelong influences on brain structure and cognitive function, however characterization of these changes often requires invasive techniques. There is a need for non-invasive assessment of early-life iron deficiency with potential to translate findings to the human clinical setting. In this study, 28 male pigs were provided either a control diet (CONT; n = 14; 23.5 mg Fe/L milk replacer) or an iron-deficient diet (ID; n = 14; 1.56 mg Fe/L milk replacer) for phase 1 of the study, from postnatal day (PND) 2 until 32...
January 27, 2018: Nutrients
https://www.readbyqxmd.com/read/29379040/mri-of-the-cervical-spinal-cord-predicts-respiratory-dysfunction-in-als
#16
G Grolez, M Kyheng, R Lopes, C Moreau, K Timmerman, F Auger, G Kuchcinski, A Duhamel, P Jissendi-Tchofo, P Besson, C Laloux, M Petrault, J C Devedjian, Thierry Pérez, Pierre François Pradat, L Defebvre, R Bordet, V Danel-Brunaud, D Devos
For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1G86R mouse model, in 40 patients and in healthy controls. Atrophy, iron overload, white matter diffusivity and neuronal loss were assessed. In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy)...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29376542/construction-of-iron-oxide-nanoparticle-based-hybrid-platforms-for-tumor-imaging-and-therapy
#17
REVIEW
Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Shi
The aim of this original review is to highlight and analyze the most recent progress and challenges in the synthesis and surface modifications of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) for multimodal imaging and therapy applications, which represent important fields in medicine in general and cancer in particular. Thus, the oncology domain is rapidly moving to a more personalized medicine including precision imaging and theranostic approaches. Novel biocompatible Fe3O4 nanoparticulate systems have been designed for enhanced and targeted cellular uptake by surface layer coating modifications, to have improved r2 relaxivity for sensitive magnetic resonance (MR) imaging applications, to have the ability to be used for dual mode imaging, and to be used for imaging-guided cancer therapy...
January 29, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29374857/dentate-nucleus-t1-hyperintensity-is-it-always-gadolinium-all-that-glitters
#18
Luca Pasquini, Maria Camilla Rossi Espagnet, Antonio Napolitano, Daniela Longo, Alice Bertaina, Emiliano Visconti, Paolo Tomà
In the last few years, several scientific papers and reports have demonstrated magnetic resonance (MR) signal intensity (SI) changes on pre-contrast T1-weighted images following multiple gadolinium-based contrast agents (GBCA) administrations, particularly following the exposure to linear GBCAs. Pathological animal and human post-mortem studies have confirmed the relationship between this radiological finding and the presence of gadolinium accumulation in vulnerable brain regions in patients with normal renal function...
January 27, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29374458/unique-depot-formed-by-an-oil-based-vaccine-facilitates-active-antigen-uptake-and-provides-effective-tumour-control
#19
Kimberly D Brewer, Genevieve M Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V Bowen, Marianne M Stanford
BACKGROUND: Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrades in vivo the antigen is passively released. DepoVax™ is a unique oil based delivery system that directly suspends the vaccine components in the oil diluent that forces immune cells to actively take up components from the formulation in the absence of passive release...
January 27, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29363758/the-impact-of-liver-steatosis-on-the-ability-of-serum-ferritin-levels-to-be-predictive-of-liver-iron-concentration-in-non-transfusion-dependent-thalassaemia-patients
#20
Paolo Ricchi, Antonella Meloni, Anna Spasiano, Silvia Costantini, Alessia Pepe, Patrizia Cinque, Aldo Filosa
This study analysed the impact of liver steatosis (LS) on the parameters of iron overload in 110 patients with non-transfusion dependent thalassaemia (NTDT). LS was diagnosed by ultrasound. Liver iron concentration (LIC) measurements were available for 64 patients who underwent a magnetic resonance imaging (MRI) scan. LS was frequent (35·5%) and was significantly more prevalent in males than in females (49·0% vs. 24·6%, P = 0·008). Patients with LS had significant higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), ALT/AST ratio and ferritin than those without, but LIC values were comparable...
January 24, 2018: British Journal of Haematology
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