keyword
MENU ▼
Read by QxMD icon Read
search

iron and magnetic resonance imaging

keyword
https://www.readbyqxmd.com/read/28089429/diagnosis-and-quantification-of-fibrosis-steatosis-and-hepatic-siderosis-through-multiparametric-magnetic-resonance-imaging
#1
M Stoopen-Rometti, E R Encinas-Escobar, C R Ramirez-Carmona, E Wolpert-Barraza, E Kimura-Hayama, L A Sosa-Lozano, R Favila, Y Kimura-Fujikami, J A Saavedra-Abril, A Loaeza-Del Castillo
BACKGROUND: The presence of liver fibrosis is the common denominator in numerous chronic liver diseases that can progress to fibrosis and hepatocellular carcinoma. Most important, with respect to frequency, are viral hepatitis and non-alcoholic fatty liver disease, the prevalence of which is increasing in epidemic proportions. Liver biopsy, albeit imperfect, continues to be the criterion standard, but in many clinical situations tends to be replaced with noninvasive imaging methods. OBJECTIVES: The aim of the present article was to describe our imaging department experience with magnetic resonance elastography and to analyze and discuss recently published results in gastroenterology, hepatology, and radiology from other authors in the literature, complemented with a PubMed search covering the last 10 years...
January 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28088078/genetically-tailored-magnetosomes-used-as-mri-probe-for-molecular-imaging-of-brain-tumor
#2
M Boucher, F Geffroy, S Prévéral, L Bellanger, E Selingue, G Adryanczyk-Perrier, M Péan, C T Lefèvre, D Pignol, N Ginet, S Mériaux
We investigate here the potential of single step production of genetically engineered magnetosomes, bacterial biogenic iron-oxide nanoparticles embedded in a lipid vesicle, as a new tailorable magnetic resonance molecular imaging probe. We demonstrate in vitro the specific binding and the significant internalization into U87 cells of magnetosomes decorated with RGD peptide. After injection at the tail vein of glioblastoma-bearing mice, we evidence in the first 2 h the rapid accumulation of both unlabeled and functionalized magnetosomes inside the tumor by Enhanced Permeability and Retention effects...
December 19, 2016: Biomaterials
https://www.readbyqxmd.com/read/28081462/in%C3%A2-vitro-evaluation-of-biodegradable-lignin-based-nanoparticles-for-drug-delivery-and-enhanced-antiproliferation-effect-in-cancer-cells
#3
Patrícia Figueiredo, Kalle Lintinen, Alexandros Kiriazis, Ville Hynninen, Zehua Liu, Tomás Bauleth-Ramos, Antti Rahikkala, Alexandra Correia, Tomáš Kohout, Bruno Sarmento, Jari Yli-Kauhaluoma, Jouni Hirvonen, Olli Ikkala, Mauri A Kostiainen, Hélder A Santos
Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12% after 12 h of incubation...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28072576/ultrasonic-computed-tomography-imaging-of-iron-oxide-nanoparticles
#4
Or Perlman, Haim Azhari
Iron oxide nanoparticles (IONPs) are becoming increasingly used and intensively investigated in the field of medical imaging. They are currently FDA approved for magnetic resonance imaging (MRI), and it would be highly desirable to visualize them by ultrasound as well. Previous reports using the conventional ultrasound B-scan (pulse-echo) imaging technique have shown very limited detectability of these particles. The aim of this study is to explore the feasibility of imaging IONPs using the through-transmission ultrasound methodology and demonstrate their detectability using ultrasonic computed tomography (UCT)...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28071883/individually-stabilized-superparamagnetic-nanoparticles-with-controlled-shell-and-size-leading-to-exceptional-stealth-properties-and-high-relaxivities
#5
Andrea Lassenberger, Andrea Scheberl, Andreas Stadlbauer, Alexander Stiglbauer, Thomas Helbich, Erik Reimhult
Superparamagnetic iron oxide nanoparticles (SPION) have received immense interest for biomedical applications, with the earliest first clinical application as negative constrast agent in being for magnetic resonance imaging (MRI). However, the first generation MRI contrast agents with dextran-enwrapped, polydisperse, iron oxide nanoparticle clusters are limited to imaging of liver and spleen; this is related to their poor colloidal stability in biological media and inability to evade clearance by the reticuloendothelial system...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28065850/deep-grey-matter-iron-accumulation-in-alcohol-use-disorder
#6
Michal Juhás, Hongfu Sun, Matthew R G Brown, Marnie B MacKay, Karl F Mann, Wolfgang H Sommer, Alan H Wilman, Serdar M Dursun, Andrew J Greenshaw
PURPOSE: Evaluate brain iron accumulation in alcohol use disorder (AUD) patients compared to controls using quantitative susceptibility mapping (QSM). METHODS: QSM was performed retrospectively by using phase images from resting state functional magnetic resonance imaging (fMRI). 20 male AUD patients and 15 matched healthy controls were examined. Susceptibility values were manually traced in deep grey matter regions including caudate nucleus, combined putamen and globus pallidus, combined substantia nigra and red nucleus, dentate nucleus, and a reference white matter region in the internal capsule...
January 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28063856/effectiveness-of-deferoxamine-on-ferric-chloride-induced-epilepsy-in-rats
#7
Xiang Zou, Shize Jiang, Zehan Wu, Yimin Shi, Shengyong Cai, Renqing Zhu, Liang Chen
Iron overload has been regarded as a common cause for refractory epilepsies in patients after hemorrhagic strokes. This study is to examine the potential epilepsy control effect of deferoxamine (DFO), an iron chelator, on a ferric chloride-induced epilepsy rat model. Twenty four rats were divided into 4 groups: group I is blank control group, group II is sham group with intracortical injection of saline, group III is epilepsy group with intracortical injection of iron and saline treatment, group IV is treatment group with intracortical injection of iron and DFO treatment...
January 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28059418/highly-versatile-spion-encapsulated-plga-nanoparticles-as-photothermal-ablators-of-cancer-cells-and-as-multimodal-imaging-agents
#8
Balasubramanian Sivakumar, Ravindran Girija Aswathy, Rebeca Romero-Aburto, Trevor Mitcham, Keith A Mitchel, Yutaka Nagaoka, Richard R Bouchard, Pulickel M Ajayan, Toru Maekawa, Dasappan Nair Sakthikumar
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28053524/dynamic-imaging-of-allogeneic-adipose-derived-regenerative-cells-transplanted-in-ischemic-hind-limb-of-apolipoprotein-e-mouse-model
#9
Yi Zheng, Jinbao Qin, Xin Wang, Zhiyou Peng, Peiyong Hou, Xinwu Lu
BACKGROUND: Transplantation of allogeneic adipose-derived regenerative cells (ADRCs) is a promising treatment modality for severe ischemic diseases. However, minimal information is available on the in vivo effects, fate, and migration of ADRCs, as well as the mechanisms of their therapeutic angiogenesis. MATERIALS AND METHODS: In this study, green fluorescent protein-expressing ADRCs (GFP-ADRCs) were obtained, labeled with acetylated 3-aminopropyltrimethoxysilane (APTS)-coated iron oxide nanoparticles (APTS NPs), and injected into an old apolipoprotein E knockout (ApoE-KO) mouse model with hind limb ischemia...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28049896/development-of-molecular-probes-based-on-iron-oxide-nanoparticles-for-in-vivo-magnetic-resonance-photoacoustic-dual-imaging-of-target-molecules-in-tumors
#10
Kohei Sano
 Molecular imaging probes that enable seamless diagnoses of tumors in the preoperative and intraoperative stages could lead to surgical resection of tumors based on highly accurate diagnoses. Because iron oxide nanoparticles (IONPs) have high proton relaxivity and high molar extinction coefficients suitable for magnetic resonance imaging (MRI) and photoacoustic imaging, respectively, we planned to develop molecular imaging probes applicable to the pre- (MRI) and intraoperative (photoacoustic imaging) stages...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28045604/technical-failure-of-mr-elastography-examinations-of-the-liver-experience-from-a-large-single-center-study
#11
Mathilde Wagner, Idoia Corcuera-Solano, Grace Lo, Steven Esses, Joseph Liao, Cecilia Besa, Nelson Chen, Ginu Abraham, Maggie Fung, James S Babb, Richard L Ehman, Bachir Taouli
Purpose To assess the determinants of technical failure of magnetic resonance (MR) elastography of the liver in a large single-center study. Materials and Methods This retrospective study was approved by the institutional review board. Seven hundred eighty-one MR elastography examinations performed in 691 consecutive patients (mean age, 58 years; male patients, 434 [62.8%]) in a single center between June 2013 and August 2014 were retrospectively evaluated. MR elastography was performed at 3.0 T (n = 443) or 1...
January 3, 2017: Radiology
https://www.readbyqxmd.com/read/28044245/mri-detection-of-endothelial-cell-inflammation-using-targeted-superparamagnetic-particles-of-iron-oxide-spio
#12
Joyce M S Chan, Maggie S H Cheung, Richard G J Gibbs, Kishore K Bhakoo
BACKGROUND: There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron oxide (SPIO) as a magnetic resonance imaging (MRI) probe for detecting inflamed endothelial cells. METHODS: The in vitro study consists of the characterisation and detection of inflammatory markers on activated endothelial cells by immunocytochemistry and MRI using biotinylated anti-P-selectin and anti-VCAM-1 (vascular cell adhesion molecule 1) antibody and streptavidin conjugated SPIO...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28043119/bioconjugated-nanoparticles-for-biosensing-in-vivo-imaging-and-medical-diagnostics
#13
Brad A Kairdolf, Ximei Qian, Shuming Nie
Bioconjugated nanoparticles are of considerable current interest because materials on the nanometer scale have unique optical, electronic, and magnetic properties with broad applications in biosensing, molecular imaging, and medical diagnostics. In particular, recent advances have led to the development of nanomaterials for a variety of applications, including iron oxide nanocrystals for magnetic resonance imaging (MRI), fluorescent quantum dots (QDs) for multiplexed molecular diagnosis and in vivo imaging, and gold nanoparticles for surface-enhanced Raman scattering...
December 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28042406/a-novel-deletion-mutation-of-exon-2-of-the-c19orf12-gene-in-an-omani-family-with-mitochondrial-membrane-protein-associated-neurodegeneration-mpan
#14
Nabil Al Macki, Ismail Al Rashdi
Mutations in the C19orf12 gene are known to cause mitochondrial membrane protein-associated neurodegeneration (MPAN), which is a neurodegeneration with brain iron accumulation (NBIA) type 4 disorder. To the best of our knowledge, this is the first report of a genetically confirmed case of MPAN from Oman. A novel homozygous deletion of exon 2 of the C19orf12 gene was confirmed on the proband, a seven-year-old girl, who presented with gait instability. Brain magnetic resonance imaging showed iron deposition on the basal ganglia...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28040545/multifunctional-near-infrared-dye-magnetic-nanoparticles-for%C3%A2-bioimaging-and-cancer-therapy
#15
Xiaoyang Hou, Huige Zhou, Liming Wang, Jianqin Tang, Guan Jiang, Chunying Chen, Yanqun Liu
Theranostics based on nanoparticles have developed rapidly in the past decade and have been widely used in the diagnosis and treatment of liver cancer, breast cancer, and other tumors. However, for skin cancers, there are limited studies. In the present study, we successfully synthesized a theranostic nanoparticle by grating IR820 onto the surface of chitosan-coated magnetic iron oxide, IR820-CS-Fe3O4, showing an excellent magnetic resonance imaging (MRI) capability and cytotoxic effects against melanoma under irradiation with a near-infrared (NIR) laser (808 nm) in vitro...
December 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28040490/biological-effects-of-iron-oxide-protamine-sulfate-complex-on-mesenchymal-stem-cells-and-its-relaxometry-based-labeling-optimization-for-cellular-mri
#16
Sushanta Kumar Mishra, Subash Khushu, Gurudutta Gangenahalli
Mesenchymal stem cells (MSCs) are frequently used as a therapeutic, but reliable imaging technique to longitudinally evaluate the engraftment of transplanted cells is inadequate. For magnetic resonance imaging (MRI), it is essential to understand the technical competence of in vitro stem cells labeling with iron oxide with regard to its relaxation behavior and significance of its biological expressions. The purpose of the study was to optimize the effective labeling of MSCs with high transverse relaxivity iron oxide contrast agent with protamine sulfate and also evaluate the biological effects (phenotype and function) of labeled MSCs...
December 28, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/28038965/inversion-recovery-ultrashort-echo-time-magnetic-resonance-imaging-a-method-for-simultaneous-direct-detection-of-myelin-and-high-signal-demonstration-of-iron-deposition-in-the-brain-a-feasibility-study
#17
Vipul R Sheth, Shujuan Fan, Qun He, Yajun Ma, Jacopo Annese, Robert Switzer, Jody Corey-Bloom, Graeme M Bydder, Jiang Du
Multiple sclerosis (MS) causes demyelinating lesions in the white matter and increased iron deposition in the subcortical gray matter. Myelin protons have an extremely short T2* (<1ms) and are not directly detected with conventional clinical magnetic resonance (MR) imaging sequences. Iron deposition also reduces T2*, leading to reduced signal on clinical sequences. In this study we tested the hypothesis that the inversion recovery ultrashort echo time (IR-UTE) pulse sequence can directly and simultaneously image myelin and iron deposition using a clinical 3T scanner...
December 28, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28032446/magnetic-resonance-imaging-of-intra-pancreatic-ductal-nanoparticle-delivery-to-islet-cells
#18
Ping Wang, Alana Ross, Byunghee Yoo, Jingsheng Yang, Christian Farrar, Chongzhao Ran, Pamela Pantazopoulos, Zdravka Medarova, Anna Moore
The absence of reliable drug delivery systems to pancreatic beta-cells hampers efficient treatment of type 1 diabetes. Nanoparticle delivery systems equipped with imaging capabilities could enable selective delivery to pancreatic islet cells. Biodistribution of nanoparticles is defined by several factors including the mode of administration, which determines accumulation in various organs. In this study we tested whether intra-pancreatic ductal injection of magnetic nanoparticles (MN) would result in efficient cellular uptake by pancreatic islet cells...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28031221/molecular-magnetic-resonance-imaging-discloses-endothelial-activation-after-transient-ischaemic-attack
#19
Aurélien Quenault, Sara Martinez de Lizarrondo, Olivier Etard, Maxime Gauberti, Cyrille Orset, Benoît Haelewyn, Helen C Segal, Peter M Rothwell, Denis Vivien, Emmanuel Touzé, Carine Ali
SEE SUN ET AL DOI101093/AWW306 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: About 20% of patients with ischaemic stroke have a preceding transient ischaemic attack, which is clinically defined as focal neurological symptoms of ischaemic origin resolving spontaneously. Failure to diagnose transient ischaemic attack is a wasted opportunity to prevent recurrent disabling stroke. Unfortunately, diagnosis can be difficult, due to numerous mimics, and to the absence of a specific test. New diagnostic tools are thus needed, in particular for radiologically silent cases, which correspond to the recommended tissue-based definition of transient ischaemic attack...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28024888/optimization-of-magnetic-retention-in-the-gastrointestinal-tract-enhanced-bioavailability-of-poorly-permeable-drug
#20
Anjali Seth, David Lafargue, Cécile Poirier, Thomas Badier, Nathalie Delory, Alain Laporte, Jean-Marie Delbos, Véronique Jeannin, Jean-Manuel Péan, Christine Ménager
Oral administration of low permeable drugs remains a challenge as they do not cross biological membrane efficiently and therefore exhibit a poor bioavailability. Herein, the effect of magnetic retention on the circulation and bioavailability of magnetic beads in the gastrointestinal tract in the presence of an external magnetic field is evaluated. Retention efficiency is imaged using magnetic resonance and near infrared techniques. The effect on bioavailability is then evaluated in a pharmacokinetic study. Iron oxide nanoparticles, the drug (dipeptidyl peptidase-IV inhibitor) and a fluorophore (Alexa Fluor-750) are co-encapsulated in chitosan-alginate core-shell beads...
December 23, 2016: European Journal of Pharmaceutical Sciences
keyword
keyword
36552
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"