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iron and magnetic resonance imaging

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https://www.readbyqxmd.com/read/29210434/nano-confinement-driven-enhanced-magnetic-relaxivity-of-spions-for-targeted-tumor-bioimaging
#1
Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Colin Ferrel, Ravindra Thakkar, Santosh Aryal
Superparamagnetic iron oxide nanoparticles (SPIONs) are highly biocompatible and have a versatile synthetic technique based on coprecipitation, reduction-precipitation, and hydrothermal methods, where Fe3+ and Fe2+ react in aqueous solutions; both these ions are present in our body and have clear metabolic pathways; therefore, they have attracted extensive research interest and development in the field of diagnostic imaging and therapy. However, most SPION-based clinical diagnostic contrast agents are discontinued due to severe pain, low transverse magnetic relaxivity range of 80-180 mM-1 s-1, shorter circulation half-life, and lack of disease specificity...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29205171/engineered-core-shell-magnetic-nanoparticle-for-mr-dual-modal-tracking-and-safe-magnetic-manipulation-of-ependymal-cells-in-live-rodents
#2
Yung-Kang Peng, Cathy N P Lui, Yu-Wei Chen, Shang-Wei Chou, Pi-Tai Chou, Ken K L Yung, S C Edman Tsang
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents...
December 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29200260/tuning-the-distance-of-rattle-shaped-ionp-shell-in-shell-nanoparticles-for-magnetically-targeted-photothermal-therapy-in-the-second-near-infrared-window
#3
Ming-Fong Tsai, Chin Hsu, Chen-Sheng Yeh, Yu-Jen Hsiao, Chia-Hao Su, Li Fang Wang
Construction of multifunctional nanoparticles (NPs) with near-infrared (NIR) plasmonic responses is considered a versatile and multifaceted platform for several biomedical applications. Herein, a double layer of Au/Ag alloy on the surface of truncated octahedral iron oxide NPs (IONPs) was prepared and the distance between the layers was controlled to exhibit broad and strong NIR absorption. The rattle-shaped IONP@shell-in-shell nanostructure showed light-response to the NIR biological window from 650 to 1300 nm for photothermal therapy (PTT) and magnetic guidance for hyperthermia and magnetic resonance imaging (MRI) diagnosis...
December 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29194739/transverse-signal-decay-under-the-weak-field-approximation-theory-and-validation
#4
Avery J L Berman, G Bruce Pike
PURPOSE: To derive an expression for the transverse signal time course from systems in the motional narrowing regime, such as water diffusing in blood. This was validated in silico and experimentally with ex vivo blood samples. METHODS: A closed-form solution (CFS) for transverse signal decay under any train of refocusing pulses was derived using the weak field approximation. The CFS was validated via simulations of water molecules diffusing in the presence of spherical perturbers, with a range of sizes and under various pulse sequences...
December 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29193796/visibility-of-an-iron-containing-fiducial-marker-in-magnetic-resonance-imaging-for-high-precision-external-beam-prostate-radiotherapy
#5
Osamu Tanaka, Hisao Komeda, Shigeki Hirose, Takuya Taniguchi, Kousei Ono, Masayuki Matsuo
INTRODUCTION: Visualization of fiducial gold markers is critical for registration on computed tomography (CT) and magnetic resonance imaging (MRI) for imaging-guided radiotherapy. Although larger markers provide better visualization on MRI, they tend to generate artifacts on CT. MRI is strongly influenced by the presence of metals, such as iron, in the body. Here we compared efficacies of a 0.5% iron-containing gold marker (GM) and a traditional non-iron-containing marker. METHODS: Twenty-seven patients underwent CT/MRI fusion-based intensity-modulated radiotherapy...
November 29, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29190464/facile-one-pot-fabrication-of-calcium-phosphate-based-composite-nanoparticles-as-delivery-and-mri-contrast-agents-for-macrophages
#6
Maki Nakamura, Ayako Oyane, Kiyoko Kuroiwa, Yoshiki Shimizu, Alexander Pyatenko, Masaki Misawa, Tomokazu Numano, Hisanori Kosuge
We developed a facile one-pot fabrication process for magnetic iron oxide-calcium phosphate (IO-CaP) composite nanoparticles via coprecipitation in labile supersaturated CaP solutions containing IO nanocrystals. All the source solutions used were clinically approved for injection, including water and magnetic IO nanocrystals (ferucarbotran, used as a negative magnetic resonance imaging (MRI) contrast agent). This ensured that the resulting nanoparticles were pathogen- and endotoxin-free. The dispersants used were clinically approved heparin sodium (heparin) or adenosine triphosphate disodium hydrate (ATP), which were added to the IO-containing labile supersaturated CaP solutions...
November 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29190176/correlation-of-serum-ferritin-levels-with-hepatic-mri-t2-and-liver-iron-concentration-in-nontransfusion-beta-thalassemia-intermediate-patients-a-contemporary-issue
#7
Mehran Karimi, Fatemeh Amirmoezi, Sezaneh Haghpanah, Seyedpouria Ostad, Mehrzad Lotfi, Sepideh Sefidbakht, Shahed Rezaian
BACKGROUND: Beta-thalassemia intermediate is a genetic disease that is milder than beta-thalassemia major. The T2* magnetic resonance imaging (MRI) technique is currently the gold standard for iron load detection. However, it is expensive and needs an expert radiologist to report findings. Therefore, we conducted this study to determine an optimal cut-off value of ferritin in proportion to T2 MRI of liver and measurement of liver iron concentration for early detection of hepatic iron overload in Beta-thalassemia intermediate patients...
November 30, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29187904/multimodality-imaging-of-angiogenesis-in-a-rabbit-atherosclerotic-model-by-gebp11-peptide-targeted-nanoparticles
#8
Tao Su, Ya-Bin Wang, Dong Han, Jing Wang, Shun Qi, Lei Gao, Ya-Hui Shao, Hong-Yu Qiao, Jiang-Wei Chen, Shu-Hui Liang, Yong-Zhan Nie, Jia-Yi Li, Feng Cao
Background and Aims: Angiogenesis is an important pathological process during progression of plaque formation, which can result in plaque hemorrhage and vulnerability. This study aims to explore non-invasive imaging of angiogenesis in atherosclerotic plaque through magnetic resonance imaging (MRI) and positron emission tomography (PET) by using GEBP11 peptide targeted magnetic iron oxide nanoparticles in a rabbit model of atherosclerosis. Methods: The dual-modality imaging probe was constructed by coupling 2, 3-dimercaptosuccinnic acid-coated paramagnetic nanoparticles (DMSA-MNPs) and the PET 68Ga chelator 1,4,7-triazacyclononane-N, N', N''-triacetic acid (NOTA) to GEBP11 peptide...
2017: Theranostics
https://www.readbyqxmd.com/read/29178028/non-invasive-measurement-of-liver-iron-concentration-using-3-tesla-magnetic-resonance-imaging-validation-against-biopsy
#9
Gaspard d'Assignies, Anita Paisant, Edouard Bardou-Jacquet, Anne Boulic, Elise Bannier, Fabrice Lainé, Martine Ropert, Jeff Morcet, Hervé Saint-Jalmes, Yves Gandon
OBJECTIVES: To evaluate the performance and limitations of the R2* and signal intensity ratio (SIR) methods for quantifying liver iron concentration (LIC) at 3 T. METHODS: A total of 105 patients who underwent a liver biopsy with biochemical LIC (LICb) were included prospectively. All patients underwent a 3-T MRI scan with a breath-hold multiple-echo gradient-echo sequence (mGRE). LIC calculated by 3-T SIR algorithm (LICSIR) and by R2* (LICR2*) were correlated with LICb...
November 24, 2017: European Radiology
https://www.readbyqxmd.com/read/29177411/ultrasmall-superparamagnetic-iron-oxide-imaging-identifies-tissue-and-nerve-inflammation-in-pain-conditions
#10
Shiqian Shen, Weihua Ding, Shihab Ahmed, Ranliang Hu, Arissa Opalacz, Sarah Roth, Zerong You, Gregory R Wotjkiewicz, Grewo Lim, Lucy Chen, Jianren Mao, John W Chen, Yi Zhang
Objective: Correlation between radiologic structural abnormalities and clinical symptoms in low back pain patients is poor. There is an unmet clinical need to image inflammation in pain conditions to aid diagnosis and guide treatment. Ferumoxytol, an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, is clinically used to treat iron deficiency anemia and showed promise in imaging tissue inflammation in human. We explored whether ferumoxytol can be used to identify tissue and nerve inflammation in pain conditions in animals and humans...
November 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29175140/comparison-of-in-vivo-targeting-ability-between-crgd-and-collagen-targeting-peptide-conjugated-nano-carriers-for-atherosclerosis
#11
Manse Kim, Abhishek Sahu, Gi Beom Kim, Gi Hoon Nam, Wooram Um, So Jin Shin, Yong Yeon Jeong, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Giyoong Tae
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis...
November 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29174413/mri-measured-myocardial-iron-load-in-patients-with-severe-diabetic-heart-failure
#12
B Wang, Y Zhang, N Sun, S Gu, F Ding, S Xu, H Zhou, Y Liu
AIM: To investigate whether a correlation exists between abnormal myocardial iron status and cardiac lipid deposition as well as other biomarkers in patients with diabetic heart failure (DHF). MATERIALS AND METHODS: Seventeen volunteers (Group 1), 26 patients with non-severe DHF (Group 2), and 25 patients with severe DHF (Group 3) were recruited for this study. Myocardial middle-section T2* mapping and septal 1H magnetic resonance spectroscopy (1H-MRS) were performed using a 3 T magnetic resonance imaging (MRI) machine to assess the iron status and lipid deposition individually...
November 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29171013/severe-infantile-onset-developmental-and-epileptic-encephalopathy-caused-by-mutations-in-autophagy-gene-wdr45
#13
Gemma L Carvill, Aijie Liu, Simone Mandelstam, Amy Schneider, Amy Lacroix, Matthew Zemel, Jacinta M McMahon, Luis Bello-Espinosa, Mark Mackay, Geoffrey Wallace, Michaela Waak, Jing Zhang, Xiaoling Yang, Stephen Malone, Yue-Hua Zhang, Heather C Mefford, Ingrid E Scheffer
Heterozygous de novo variants in the autophagy gene, WDR45, are found in beta-propeller protein-associated neurodegeneration (BPAN). BPAN is characterized by adolescent onset dementia and dystonia; 66% patients have seizures. We asked whether WDR45 was associated with developmental and epileptic encephalopathy (DEE). We performed next generation sequencing of WDR45 in 655 patients with developmental and epileptic encephalopathies. We identified 3/655 patients with DEE plus 4 additional patients with de novo WDR45 pathogenic variants (6 truncations, 1 missense); all were female...
November 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/29169710/dysmetabolic-iron-overload-syndrome-dios
#14
Yves Deugnier, Édouard Bardou-Jacquet, Fabrice Lainé
Dysmetabolic iron overload syndrome (DIOS) corresponds to mild increase in both liver and body iron stores associated with various components of metabolic syndrome in the absence of any identifiable cause of iron excess. It is characterized by hyperferritinemia with normal or moderately increased transferrin saturation, one or several metabolic abnormalities (increased body mass index with android distribution of fat, elevated blood pressure, dyslipidaemia, abnormal glucose metabolism, steatohepatitis), and mild hepatic iron excess at magnetic resonance imaging or liver biopsy...
November 20, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29166921/identification-of-epidermal-growth-factor-receptor-positive-glioblastoma-using-lipid-encapsulated-targeted-superparamagnetic-iron-oxide-nanoparticles-in-vitro
#15
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29165872/manganese-dioxide-coated-ws2-fe3-o4-ssio2-nanocomposites-for-ph-responsive-mr-imaging-and-oxygen-elevated-synergetic-therapy
#16
Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attached...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29158816/dual-targeting-theranostic-system-with-mimicking-apoptosis-to-promote-myocardial-infarction-repair-via-modulation-of-macrophages
#17
Jingli Chen, Jun Yang, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang, Xin Zhang
Currently unsatisfactory treatment of myocardial infarction (MI) is due to the unbridled inflammation and the delayed diagnosis at the early stage. To address these problems, firstly, phosphatidylserine (PS) was used to modulate the phenotypes of macrophages (MΦ) and resolve the early inflammation via binding to PS receptors (PSR) on macrophage surface. Secondly, highly-sensitive magnetic iron oxide nanocubes (MIONs) were adopted to realize the early visualization via magnetic resonance imaging (MRI). However, the major drawback for MIONs as contrast agents was their hydrophobic properties and insufficient delivery...
2017: Theranostics
https://www.readbyqxmd.com/read/29155624/functional-and-targeted-lymph-node-imaging-in-prostate-cancer-current-status-and-future-challenges
#18
REVIEW
Harriet C Thoeny, Sebastiano Barbieri, Johannes M Froehlich, Baris Turkbey, Peter L Choyke
Patients with prostate cancer who have regional lymph node (LN) metastases face an increased risk of death from disease and are therefore treated aggressively. Surgical LN dissection is the established method of staging regional nodes; however, this invasive technique carries substantial morbidities and a noninvasive imaging method is needed to reduce or eliminate the need for extended pelvic LN dissections (ePLND). Conventional computed tomography and magnetic resonance (MR) imaging have proven insensitive and nonspecific because both use nodal size criteria, which is notoriously inaccurate...
December 2017: Radiology
https://www.readbyqxmd.com/read/29153575/persistent-iron-within-the-infarct-core%C3%A2-after-st-segment-elevation-myocardial-infarction-implications-for-left-ventricular-remodeling-and-health%C3%A2-outcomes
#19
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
OBJECTIVES: This study sought to determine the incidence and prognostic significance of persistent iron in patients post-ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The clinical significance of persistent iron within the infarct core after STEMI complicated by acute myocardial hemorrhage is poorly understood. METHODS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction])...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29153377/iatrogenic-iron-overload-and-its-potential-consequences-in-patients-on-hemodialysis
#20
Guy Rostoker, Nosratola D Vaziri
Iron overload was considered rare in hemodialysis patients until recently, but its clinical frequency is now increasingly recognized. The liver is the main site of iron storage and the liver iron concentration (LIC) is closely correlated with total iron stores in patients with secondary hemosiderosis and genetic hemochromatosis. Magnetic resonance imaging (MRI) is now the gold standard method for estimating and monitoring LIC. Studies of LIC in hemodialysis patients by magnetic susceptometry thirteen years ago and recently by quantitative MRI have demonstrated a relation between the risk of iron overload and the use of intravenous (IV) iron products prescribed at doses determined by the iron biomarker cutoffs contained in current anemia management guidelines...
November 16, 2017: La Presse Médicale
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