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iron and magnetic resonance imaging

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https://www.readbyqxmd.com/read/28335985/aqueous-phase-synthesis-of-iron-oxide-nanoparticles-and-composites-for-cancer-diagnosis-and-therapy
#1
REVIEW
Jingchao Li, Shige Wang, Xiangyang Shi, Mingwu Shen
The design and development of multifunctional nanoplatforms for biomedical applications still remains to be challenging. This review reports the recent advances in aqueous-phase synthesis of iron oxide nanoparticles (Fe3O4 NPs) and their composites for magnetic resonance (MR) imaging and photothermal therapy of cancer. Water dispersible and colloidally stable Fe3O4 NPs synthesized via controlled coprecipitation route, hydrothermal route and mild reduction route are introduced. Some of key strategies to improve the r2 relaxivity of Fe3O4 NPs and to enhance their uptake by cancer cells are discussed in detail...
March 14, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28335351/modified-nanoemulsions-with-iron-oxide-for-magnetic-resonance-imaging
#2
Yongyi Fan, Rui Guo, Xiangyang Shi, Steven Allen, Zhengyi Cao, James R Baker, Su He Wang
A nanoemulsion (NE) is a surfactant-based, oil-in-water, nanoscale, high-energy emulsion with a mean droplet diameter of 400-600 nm. When mixed with antigen and applied nasally, a NE acts as a mucosal adjuvant and induces mucosal immune responses. One possible mechanism for the adjuvant effect of this material is that it augments antigen uptake and distribution to lymphoid tissues, where the immune response is generated. Biocompatible iron oxide nanoparticles have been used as a unique imaging approach to study the dynamics of cells or molecular migration...
November 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335228/fabricating-water-dispersible-superparamagnetic-iron-oxide-nanoparticles-for-biomedical-applications-through-ligand-exchange-and-direct-conjugation
#3
Tina Lam, Pramod K Avti, Philippe Pouliot, Foued Maafi, Jean-Claude Tardif, Éric Rhéaume, Frédéric Lesage, Ashok Kakkar
Stable superparamagnetic iron oxide nanoparticles (SPIONs), which can be easily dispersed in an aqueous medium and exhibit high magnetic relaxivities, are ideal candidates for biomedical applications including contrast agents for magnetic resonance imaging. We describe a versatile methodology to render water dispersibility to SPIONs using tetraethylene glycol (TEG)-based phosphonate ligands, which are easily introduced onto SPIONs by either a ligand exchange process of surface-anchored oleic-acid (OA) molecules or via direct conjugation...
May 26, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28328144/diagnosing-and-preventing-iron-overload
#4
Ganesh Ramanathan, John K Olynyk, Paolo Ferrari
Absolute or functional iron (Fe) deficiency is an important determinant of anemia in hemodialysis patients and parenteral Fe is routinely used to treat this condition in conjunction with erythropoiesis stimulating agents. While restoration of hemoglobin toward the target range is a good outcome of Fe replacement, it is well known that Fe overload and toxicity may be adverse consequences of this therapy. Dialysis clinical practice guidelines recommend tailoring Fe therapy based on transferrin saturation and serum ferritin levels...
March 22, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28327075/magnetic-nanobubbles-with-potential-for-targeted-drug-delivery-and-trimodal-imaging-in-breast-cancer-an-in-vitro-study
#5
Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging...
March 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28326037/differences-on-brain-connectivity-in-adulthood-are-present-in-subjects-with-iron-deficiency-anemia-in-infancy
#6
Cecilia Algarin, Keerthana Deepti Karunakaran, Sussanne Reyes, Cristian Morales, Betsy Lozoff, Patricio Peirano, Bharat Biswal
Iron deficiency continues to be the most prevalent micronutrient deficit worldwide. Since iron is involved in several processes including myelination, dopamine neurotransmission and neuronal metabolism, the presence of iron deficiency anemia (IDA) in infancy relates to long-lasting neurofunctional effects. There is scarce data regarding whether these effects would extend to former iron deficient anemic human adults. Resting state functional magnetic resonance imaging (fMRI) is a novel technique to explore patterns of functional connectivity...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28324908/-magnetic-sentinel-lymph-node-detection-in-prostate-cancer-after-intraprostatic-injection-of-superparamagnetic-iron-oxide-nanoparticles
#7
Alexander Winter, Svenja Engels, Tobias Kowald, Tina Susanne Paulo, Holger Gerullis, Ajay Chavan, Friedhelm Wawroschek
In prostate cancer, reliable information about the lymph node status is of great importance for accurate staging and the optimal planning of treatment. Despite recent advances in imaging, the histological detection of metastases, or pelvic lymphadenectomy (PLND), continues to be the most reliable method for lymph node staging in clinically localised prostate cancer, especially as this procedure enables the detection of small or micrometastases. Radioisotope-guided sentinel PLND (sPLND) demonstrates high sensitivity in the detection of lymph node metastases as well as low morbidity in prostate cancer because of the targeted removal of a relatively small number of lymph nodes...
March 21, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28298928/biological-characteristics-of-fluorescent-superparamagnetic-iron-oxide-labeled-human-dental-pulp-stem-cells
#8
Liang Ma, Ming-Wei Li, Yu Bai, Hui-Hui Guo, Sheng-Chao Wang, Qing Yu
Tracking transplanted stem cells is necessary to clarify cellular properties and improve transplantation success. In this study, we investigate the effects of fluorescent superparamagnetic iron oxide particles (SPIO) (Molday ION Rhodamine-B™, MIRB) on biological properties of human dental pulp stem cells (hDPSCs) and monitor hDPSCs in vitro and in vivo using magnetic resonance imaging (MRI). Morphological analysis showed that intracellular MIRB particles were distributed in the cytoplasm surrounding the nuclei of hDPSCs...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28295954/clinical-quantitative-susceptibility-mapping-qsm-biometal-imaging-and-its-emerging-roles-in-patient-care
#9
REVIEW
Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M Gillen, Alan H Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia-Yi Chiang, Jonathan W Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min Lou, Brian H Kopell, Michael G Kaplitt, David Devos, Toshinori Hirai, Xuemei Huang, Yukunori Korogi, Alexander Shtilbans, Geon-Ho Jahng, Daniel Pelletier, Susan A Gauthier, David Pitt, Ashley I Bush, Gary M Brittenham, Martin R Prince
Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28295188/how-we-manage-iron-overload-in-sickle-cell-patients
#10
REVIEW
Thomas D Coates, John C Wood
Blood transfusion plays a prominent role in the management of patients with sickle cell disease (SCD), but causes significant iron overload. As transfusions are used to treat the severe complications of SCD, it remains difficult to distinguish whether organ damage is a consequence of iron overload or is due to the complications treated by transfusion. Better management has resulted in increased survival, but prolonged exposure to iron puts SCD patients at greater risk for iron-related complications that should be treated...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28292235/paramagnetic-and-superparamagnetic-inorganic-nanoparticles-for-t1-weighted-magnetic-resonance-imaging
#11
Leyong Zeng, Di Wu, Ruifen Zou, Tianxiang Chen, Jinchao Zhang, Aiguo Wu
Magnetic resonance imaging (MRI) has become a promising technique in the early diagnosis of cancers, especially the application of contrast agents can further enhance the detection limitation. Compared with the dark signal in "negative" contrast agents (T2), "positive" contrast agents (T1) with bright signal are more desirable for high-resolution imaging. However, the clinical used gadolinium complexes have short circulation time and the risk of nephrogenic system fibrosis. Therefore, to overcome the disadvantage of T2 agents and traditional T1 agents, it is very interesting to develop nano-scaled T1-weighted MRI contrast agents with safer and more precise imaging performance...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28289798/-helpful-instrumental-examinations-in-idiopathic-parkinson-s-disease
#12
U Walter, H Zach, I Liepelt-Scarfone, W Maetzler
BACKGROUND: The clinical diagnosis of idiopathic Parkinson's disease (iPD) can be challenging. In these cases, additional diagnostic methods are available that can help to improve diagnostic accuracy. OBJECTIVES, MATERIAL AND METHODS: This article provides an overview of currently available and promising novel ancillary methods for the early and differential diagnosis of iPD. RESULTS: Imaging tools, such as 1.5 Tesla magnetic resonance imaging (MRI) and computed tomography (CT) are mainly used for the differentiation between iPD and symptomatic parkinsonian syndromes (PS)...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28283108/higher-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-in-multiple-sclerosis-patients-is-related-to-spinal-cord-lesions
#13
M Minár, D Petrleničová, P Valkovič
BACKGROUND: Multiple sclerosis (MS) is connected with higher prevalence of secondary restless legs syndrome/Willis-Ekbom disease (RLS/WED). Aim of this study was to determine risk factor for developing symptoms of RLS in MS patients. METHODS: In cross-sectional study we examined 200 random MS patients. After obtaining informed consents, patients undervent a structured interview based on RLS and MS symptoms and characteristics, demographic, and health-related data...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28281182/evaluation-of-magnetonanoparticles-conjugated-with-new-angiogenesis-peptides-in-intracranial-glioma-tumors-by-mri
#14
Erica Aparecida de Oliveira, Jelena Lazovic, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney Pope
Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
March 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28280341/a-facile-method-to-prepare-superparamagnetic-iron-oxide-and-hydrophobic-drug-encapsulated-biodegradable-polyurethane-nanoparticles
#15
Kuo-Wei Cheng, Shan-Hui Hsu
Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28280327/biocompatibility-of-very-small-superparamagnetic-iron-oxide-nanoparticles-in-murine-organotypic-hippocampal-slice-cultures-and-the-role-of-microglia
#16
Martin Pohland, Robert Glumm, Frank Wiekhorst, Jürgen Kiwit, Jana Glumm
Superparamagnetic iron oxide nanoparticles (SPIO) are applied as contrast media for magnetic resonance imaging (MRI) and treatment of neurologic diseases despite the fact that important information concerning their local interactions is still lacking. Due to their small size, SPIO have great potential for magnetically labeling different cell populations, facilitating their MRI tracking in vivo. Before SPIO are applied, however, their effect on cell viability and tissue homoeostasis should be studied thoroughly...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28279919/active-targeting-theranostic-iron-oxide-nanoparticles-for-mri-and-magnetic-resonance-guided-focused-ultrasound-ablation-of-lung-cancer
#17
Zhongling Wang, Ruirui Qiao, Na Tang, Ziwei Lu, Han Wang, Zaixian Zhang, Xiangdong Xue, Zhongyi Huang, Siruo Zhang, Guixiang Zhang, Yuanpei Li
Despite its great promise in non-invasive treatment of cancers, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is currently limited by the insensitivity of magnetic resonance imaging (MRI) for visualization of small tumors, low efficiency of in vivo ultrasonic energy deposition, and damage to surrounding tissues. We hereby report the development of an active targeting nano-sized theranostic superparamagnetic iron oxide (SPIO) platform for significantly increasing the imaging sensitivity and energy deposition efficiency using a clinical MRgFUS system...
March 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28275562/a-comprehensive-literatures-update-of-clinical-researches-of-superparamagnetic-resonance-iron-oxide-nanoparticles-for-magnetic-resonance-imaging
#18
REVIEW
Yì Xiáng J Wáng, Jean-Marc Idée
This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years. PubMed database was used for literature search, and the search terms were (SPIO OR superparamagnetic iron oxide OR Resovist OR Ferumoxytol OR Ferumoxtran-10) AND (MRI OR magnetic resonance imaging). The literature search results show clinical research on SPIO remains robust, particularly fuelled by the approval of ferumoxytol for intravenously administration...
February 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28267532/r2-relaxometry-of-the-pancreas-in-patients-with-human-hemochromatosis-protein-associated-hereditary-hemochromatosis
#19
B Henninger, S Rauch, H Zoller, M Plaikner, W Jaschke, C Kremser
PURPOSE: To evaluate pancreatic iron in patients with human hemochromatosis protein associated hereditary hemochromatosis (HHC) using R2* relaxometry. MATERIALS AND METHODS: 81 patients (58 male, 23 female; median age 49.5, range 10-81 years) with HHC were retrospectively studied. All underwent 1.5T magnetic resonance imaging (MRI) of the abdomen. A fat-saturated multi-gradient echo sequence with 12 echoes (TR=200ms; TE-initial 0.99ms; Delta-TE 1.41ms; 12 echoes; flip-angle: 20°) was used for the R2* quantification of the liver and the pancreas...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28256824/indocyanine-green-loaded-magnetic-carbon-nanoparticles-for-near-infrared-fluorescence-magnetic-resonance-dual-modal-imaging-and-photothermal-therapy-of-tumor
#20
Saijie Song, He Shen, Tao Yang, Lina Wang, Han Fu, Huabing Chen, Zhijun Zhang
Malignant tumor incidences have been rapidly rising recently and are becoming a serious threat to human health. Herein, a multifunctional cancer targeted theranostic nanoplatform is developed by in situ growth of iron oxide magnetic nanoparticles on carbon nanoparticles, and then loaded with fluorescent dye indocyanine green (ICG@MCNPs). The loading of ICG on the nanoplatform significantly improves its photostability, and hence facilitates long-term near-infrared fluorescence (NIRF) imaging and efficient photothermal therapy (PTT) of tumor...
March 22, 2017: ACS Applied Materials & Interfaces
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