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https://www.readbyqxmd.com/read/28823141/targeted-therapy-of-ovarian-cancer-including-immune-check-point-inhibitor
#1
Jin Young Kim, Chi Heum Cho, Hong Suk Song
Epithelial ovarian cancer is the eighth most common cause of cancer-related deaths in women because most patients present with advanced stage disease at the time of diagnosis. Although cytoreductive surgery and platinum-based chemotherapy remain the gold standards of treatment, the recurrence rate of ovarian cancer remains high. Attempts to improve this standard two-drug chemotherapy by adding a third cytotoxic drug have failed to affect either progression-free survival or overall survival and have resulted in an increase in toxic side effects...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823066/distribution-and-health-risk-assessment-to-heavy-metals-near-smelting-and-mining-areas-of-hezhang-china
#2
Meryem Briki, Yi Zhu, Yang Gao, Mengmeng Shao, Huaijian Ding, Hongbing Ji
Mining and smelting areas in Hezhang have generated a large amount of heavy metals into the environment. For that cause, an evaluative study on human exposure to heavy metals including Co, Ni, Cu, Zn, Cr, As, Cd, Pb, Sb, Bi, Be, and Hg in hair and urine was conducted for their concentrations and correlations. Daily exposure and non-carcinogenic and carcinogenic risk were estimated. Sixty-eight scalp hair and 66 urine samples were taken from participants of different ages (6-17, 18-40, 41-60, and ≥ 65 years) living in the vicinity of an agricultural soil near mine and smelting areas...
August 19, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28822892/angiolymphoid-hyperplasia-with-eosinophilia-involving-the-common-digital-artery-of-the-hand-a-case-report-and-classification-of-upper-limb-lesions
#3
Mohammad M Al-Qattan, Maha Arafah, Felwa Al-Marshad
INTRODUCTION: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign reactive inflammatory lesion. The usual presentation is a single or multiple skin nodules of the head and neck. Involvement of the hand is very rare and there have been no comprehensive reviews on ALHE of the upper limb. In this paper, we report on a case involving the common digital artery of the hand. We also review the literature and offer two classification systems for upper limb lesions: One according to the primary structure involved, and the other according to the presentation with either single or multiple lesions...
August 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28822863/an-x-ray-absorption-fine-structure-spectroscopy-study-of-metal-sorption-to-graphene-oxide
#4
Allison R Showalter, Thomas A Duster, Jennifer E S Szymanowski, Chongzheng Na, Jeremy B Fein, Bruce A Bunker
Remediation and prevention of environmental contamination by toxic metals is an ongoing issue. Additionally, improving water filtration systems is necessary to prevent toxic metals from circulating through the water supply. Graphene oxide (GO) is a highly sorptive material for a variety of heavy metals under different ionic strength conditions over a wide pH range, making it a promising candidate for use in metal adsorption from contaminated sites or in filtration systems. We present X-ray absorption fine structure (XAFS) spectroscopy results investigating the binding environment of Cd (II), U(VI) and Pb(II) ions onto multi-layered graphene oxide (MLGO)...
August 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822832/combined-immunodeficiency-with-ebv-positive-b-cell-lymphoma-and-epidermodysplasia-verruciformis-due-to-a-novel-homozygous-mutation-in-rasgrp1
#5
Craig D Platt, Ari J Fried, Rodrigo Hoyos-Bachiloglu, G Naheed Usmani, Birgitta Schmidt, Jennifer Whangbo, Roberto Chiarle, Janet Chou, Raif S Geha
RASGRP1 is a guanine-nucleotide-exchange factor essential for MAP-kinase mediated signaling in lymphocytes. We report the second case of RASGRP1 deficiency in a patient with a homozygous nonsense mutation in the catalytic domain of the protein. The patient had epidermodysplasia verruciformis, suggesting a clinically important intrinsic T cell function defect. Like the previously described patient, our proband also presented with CD4(+) T cell lymphopenia, impaired T cell proliferation to mitogens and antigens, reduced NK cell function, and EBV-associated lymphoma...
August 16, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28822787/global-regional-and-national-deaths-prevalence-disability-adjusted-life-years-and-years-lived-with-disability-for-chronic-obstructive-pulmonary-disease-and-asthma-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#6
(no author information available yet)
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year...
August 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28822769/somatic-mutation-analysis-in-melanoma-using-targeted-next-generation-sequencing
#7
Allen P Miraflor, Francine B de Abreu, Jason D Peterson, Scott A Turner, Christopher I Amos, Gregory J Tsongalis, Shaofeng Yan
Advanced stage malignant melanoma often responds poorly to therapy with low survival rates. New therapeutic approaches are based upon a growing understanding of the underlying molecular abnormalities. We demonstrate the feasibility of a next generation sequencing (NGS) assay, which targets hotspots in 50 cancer genes, to assess genotypes that may influence therapeutic selection and response. DNA was extracted from formalin fixed paraffin embedded (FFPE) melanoma specimens to create multiplexed libraries which were sequenced...
August 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28822650/progressive-and-reversible-conduction-disease-with-checkpoint-inhibitors
#8
Neeti Reddy, Rohit Moudgil, Juan C Lopez-Mattei, Kaveh Karimzad, Elie N Mouhayar, Neeta Somaiah, Anthony P Conley, Shreyaskumar Patel, Dana E Giza, Cezar Iliescu
Novel antineoplastic therapies are focused on harnessing our own immune system to fight cancer. To that end, cytotoxic T-lymphocyte-associated antigen 4 and programmed death ligand 1 are 2 coinhibitory signals that play central roles in decreasing T-cell response and represent a class of medications termed "checkpoint inhibitors." We present an unusual case of progressive conduction abnormalities induced by checkpoint inhibitors. Prompt medical intervention resulted in full recovery. Despite the anticancer efficacy, the newer antineoplastic agents pose a significant and often life-threatening risk of cardiotoxicity...
June 8, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28822629/acute-intrapartum-rupture-of-the-pubic-symphysis-requiring-resuscitation-and-surgical-intervention-a-case-report
#9
Marie Buitendyk, Barbara Brennan, Parag Vora, Patricia Smith, Stephanie Winsor
BACKGROUND: Pubic symphysis rupture significant enough to cause serious complications or require surgical intervention is exceedingly rare. Here we review the literature and examine the details of a unique presentation. CASE: A 27-year-old woman presented in labour at 34+6 weeks gestation after an uncomplicated monochorionic-diamniotic twin pregnancy. After vaginal delivery, she developed a substantial labial hematoma. Hours later, she became hemodynamically unstable...
August 16, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28822621/chondrosarcoma-of-the-epiglottis-a-case-report-and-literature-review
#10
REVIEW
Jonathan Choi, Harish Dharmarajan, Andrew Victores, Ashley Wenaas, Julina Ongkasuwan
BACKGROUND: Laryngeal chondrosarcoma (LCS) is an exceedingly rare malignancy and least frequently reported in the epiglottis. METHODS AND RESULTS: We report a case of a 71-year-old male smoker who presented with sore throat, dysphagia, and odynophagia for 3 months. Computed tomography scan revealed an inhomogeneously enhancing necrotic mass emanating from the right epiglottis and traveling along the aryepiglottic fold. The mass was removed via endoscopic en bloc laser resection...
August 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28822609/transient-vocal-cord-paralysis-following-central-venous-hemodialysis-catheter-insertion
#11
Gül Pamukçu Günaydın, Selahattin Gürü, Elif Aslan Taş, Fatih Tanrıverdi, Gülhan Kurtoğlu Çelik
In this article, we present a case of recurrent laryngeal nerve palsy not caused by nerve injury but due to local anesthetic infiltration that was applied prior to central venous catheterization. A 47-year-old female patient was admitted to emergency room with fatigue and nausea and was diagnosed with acute renal failure. Right jugular venous catheterization was performed for emergency hemodialysis with Seldinger technique using middle approach. Within minutes and immediately after the procedure the patient complained of hoarseness and shortness of breath, and she had stridor in her physical exam...
August 15, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28822567/classification-and-clinical-management-of-retrograde-peri-implantitis-associated-with-apical-periodontitis-a-proposed-classification-system-and-case-report
#12
Nima D Sarmast, Howard H Wang, Ali S Sajadi, Nikola Angelov, Samuel O Dorn
Biological complications involving dental implants include peri-implant diseases such as peri-implant mucositis and peri-implantitis. The latter presents with progressive bone loss from the alveolar crest in a coronal apical direction. However, a separate disease entity termed retrograde peri-implantitis (RPI), which presents with progressive bone loss at the periapex of the implant, also exists and may be of particular interest to endodontists because it typically presents with periapical pathology of both the implant and adjacent tooth or at a site that previously housed an endodontically treated tooth...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822540/life-threatening-complications-and-mortality-of-minimally-invasive-pectus-surgery
#13
André Hebra, Robert E Kelly, Marcelo M Ferro, Mustafa Yüksel, Jose Ribas M Campos, Donald Nuss
The prevalence and type of life-threatening complications related to the minimally invasive repair of pectus excavatum (MIRPE) and bar removal are unknown and underreported. The purpose of this communication is to make surgeons aware of the risk of these life threatening complications as well as the modifications which have been developed to prevent them. METHODS: Data related to life-threatening complications of Pectus Excavatum (PE) patients was obtained from four sources: 1. A survey of Chest Wall International Group (CWIG) surgeons who specialize in repairing congenital chest wall malformations, 2...
July 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28822481/function-and-effectiveness-of-natural-refuge-in-irm-strategies-for-bt-crops
#14
REVIEW
Yunhe Li, Yulin Gao, Kongming Wu
Several strategies involving refuge have been proposed for delaying insect resistance to Bt crops. The report was focused on the unstructured 'natural' refuges that contain plants naturally presented as part of the cropping system in the form of non-Bt plants that differ from Bt plant species, or wild host plants of the target pests. The cases of natural refuges applied in different countries were analyzed, and the factors that favor their success are discussed. The results indicate that the effectiveness of a natural refuge strategy depends on the biological characteristics of the target pest, the spatial and temporal distribution and abundance of the host plants in the agricultural system and the quality of the host plants for the pest species...
June 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28822460/-french-society-for-biological-psychiatry-and-neuropsychopharmacology-and-fondation-fondamental-task-force-formal-consensus-for-the-management-of-treatment-resistant-depression
#15
T Charpeaud, J-B Genty, S Destouches, A Yrondi, S Lancrenon, N Alaïli, F Bellivier, D Bennabi, T Bougerol, V Camus, T D'amato, O Doumy, F Haesebaert, J Holtzmann, C Lançon, M Lefebvre, F Moliere, I Nieto, R Richieri, L Schmitt, F Stephan, G Vaiva, M Walter, M Leboyer, W El-Hage, E Haffen, P-M Llorca, P Courtet, B Aouizerate
Major depression represents among the most frequent psychiatric disorders in the general population with an estimated lifetime prevalence of 16-17%. It is characterized by high levels of comorbidities with other psychiatric conditions or somatic diseases as well as a recurrent or chronic course in 50 to 80% of the cases leading to negative repercussions on the daily functioning, with an impaired quality of life, and to severe direct/indirect costs. Large cohort studies have supported that failure of a first-line antidepressant treatment is observed in more than 60% of patients...
September 2017: L'Encéphale
https://www.readbyqxmd.com/read/28822439/-multisystemic-smooth-muscle-dysfunction-syndrome-in-children-a-case-report-and-literature-review
#16
Y L Zhou, Y Y Zhang, B L Cheng, D Xu, L F Tang, Z M Chen
Objective: To analyze the clinical characteristics and diagnosis of multisystemic smooth muscle dysfunction syndrome(MSMDS). Method: Clinical data of a case diagnosed as MSMDS and hospitalized in our hospital in July 2016 was retrospectively analyzed. Literature search was performed at databases of PubMed, Wanfang, China National Knowledge Infrastructure and VIP with the key words "multisystemic smooth muscle dysfunction syndrome" "ACTA2" . The literature retrieval was confined from January 1980 to November 2016...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822401/esophageal-perforation-a-common-clinical-problem-with-many-different-management-options
#17
Lloyd M Felmly, Hyejin Kwon, Chadrick E Denlinger, Jacob A Klapper
Esophageal perforation is a complex clinical entity that has multiple etiologies and variability in presentation, making it challenging to diagnose and treat. The mortality of esophageal perforation has improved because therapies have evolved. Whereas primary repair is the standard of care, multiple treatments may be employed successfully. We retrospectively reviewed all cases of suspected or confirmed esophageal perforation that were admitted to the thoracic surgery service at our institution between January 2011 and June 2016...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822351/granulomatous-rosacea-a-case-report
#18
A Kelati, F Z Mernissi
BACKGROUND: Granulomatous rosacea is a rare chronic inflammatory skin disease with an unknown origin. The role of Demodex follicularum in its pathogenesis is currently proved. CASE PRESENTATION: We report a case of a 54-year-old Moroccan man with a 3-month history of erythematous, nonpruritic papules on the lateral side around the eyes. Dermoscopy and histology confirmed the diagnosis of granulomatous rosacea. CONCLUSIONS: We describe another clinical presentation of granulomatous rosacea with a clinical-dermoscopic-pathological correlation...
August 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28822312/ossifying-fibromyxoid-tumor-of-the-trunk-mimicking-hydatid-cyst-a-case-report
#19
Nihed Abdessayed, Sarra Mestiri, Houssem Ammar, Ahlem Bdioui, Amine Chhaidar, Omar Toumi, Nozha Mhamdi, Rahul Gupta, Marwa Guerfela, Moncef Mokni
INTRODUCTION: Ossifying fibromyxoid tumor (OFMT) is a rare lesion that generally occurs in the soft tissues of proximal limbs, head or neck and presents as a slowly growing mass. Abdominal or trunk locations are extremely rare. PRESENTATION OF CASE: We report a case of 50-year-old man who presented with a painless, slow growing epigastric mass for 5 years. Radiologic assessment revealed a well circumscribed median subcutaneous parietal mass lesion present in front of the xiphoid process suspicious of a calcified hydatid cyst...
July 22, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28822003/pedophilia-themed-obsessive-compulsive-disorder-assessment-differential-diagnosis-and-treatment-with-exposure-and-response-prevention
#20
Simone Leavell Bruce, Terence H W Ching, Monnica T Williams
Fears of sexually harming children are fairly common among clients suffering from obsessive-compulsive disorder (OCD), yet these symptoms are largely unrecognized and frequently misdiagnosed by mental health professionals. Specifically, clients with pedophilia-themed OCD (P-OCD) experience excessive worries and distressing intrusive thoughts about being sexually attracted to, and sexually violating, children. Expressing these concerns may provoke misjudgments from uninformed mental health professionals that a client is presenting instead with pedophilic disorder...
August 18, 2017: Archives of Sexual Behavior
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