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https://www.readbyqxmd.com/read/29228513/an-analysis-of-the-morbidity-and-mortality-of-diabetes-mellitus-in-a-forensic-context
#1
Chong Zhou, Roger W Byard
To investigate the spectrum of diseases seen in diabetes mellitus in a forensic context, all autopsy reports of diabetic individuals who presented to Forensic Science, South Australia (FSSA), over a 5-year period from 2005 to 2009 were studied. The leading cause of death was cardiovascular disease (55.0%), followed by unnatural deaths (15.4%) and infections (9.4%). In type 1 diabetics, principal causes of death included cardiovascular disease (44.7%), acute metabolic complications (18.7%), unnatural deaths (17...
December 11, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29228505/a-spatio-temporal-exposure-hazard-model-for-assessing-biological-risk-and-impact
#2
Emily Walker, Melen Leclerc, Jean-François Rey, Rémy Beaudouin, Samuel Soubeyrand, Antoine Messéan
We developed a simulation model for quantifying the spatio-temporal distribution of contaminants (e.g., xenobiotics) and assessing the risk of exposed populations at the landscape level. The model is a spatio-temporal exposure-hazard model based on (i) tools of stochastic geometry (marked polygon and point processes) for structuring the landscape and describing the exposed individuals, (ii) a dispersal kernel describing the dissemination of contaminants from polygon sources, and (iii) an (eco)toxicological equation describing the toxicokinetics and dynamics of contaminants in affected individuals...
December 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29228431/the-association-of-pancreatic-cystosis-and-ipmn-in-cystic-fibrosis-case-report-and-literature-review
#3
D Pagliari, A Saviano, M L Serricchio, A A Dal Lago, M G Brizi, R Manfredi, G Costamagna, F Attili
Pancreatic cystosis is a rare presentation of cystic fibrosis involving pancreatic gland. To date, only very few cases of pancreatic cystosis have been described in literature. Pancreatic cystosis may begin during the second decade of life and is the rarest presentation of cystic fibrosis. This disease is characterized by the presence of multiloculated cysts without ductal system communication of different sizes in all the pancreatic tissue. Herein, we report a case of a young woman affected by cystic fibrosis that was admitted to our Pancreatic Centre to evaluate a picture of diffuse multiloculated pancreatic cysts...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228424/circulating-ship2-mrna-as-a-novel-biomarker-in-the-diagnosis-and-prognosis-of-gastric-cancer
#4
J-F Xie, N-S Xie, J-H Tang, Q-P Gu, Q-T Luo
OBJECTIVE: Previous studies showed the aberrant expression of Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) in GC tissue. However, the exact role of circulating SHIP2 in GC remains unclear. The aim of this manuscript was to analyze potential diagnostic and prognostic value of circulating SHIP2 levels in GC. PATIENTS AND METHODS: Circulating SHIP2 expression was detected in the plasma of 156 GC patients and 60 healthy controls by qRT-PCR. The receiver operating characteristic (ROC) curves were plotted to explore the reliability of circulating SHIP2 in detecting GC...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228410/clinical-course-of-eosinophilic-cellulitis
#5
Hideki Ozawa, Kousuke Kuwano, Saki Manabe, Toru Ishihara, Masamichi Komatsu, Takako Kobayashi, Hidetaka Yanagi, Masayuki Oki, Atsushi Takagi
The patient was a previously healthy 23-year-old woman who made an outpatient visit to our hospital's Department of General Internal Medicine after developing pain and edema of the lower legs a week earlier. The patient was diagnosed with eosinophilic cellulitis (EC) based on an increased eosinophil count of 5,418/mm3 and the results of a skin biopsy of the lower leg that showed eosinophilic infiltration of the dermal tissue. Her condition improved after oral prednisone therapy. EC presents clinically as edema and eosinophilia...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29228402/lymph-node-metastasis-in-early-gastric-adenocarcinoma-in-the-united-states-of-america
#6
Sridevi K Pokala, Chao Zhang, Zhengjia Chen, Anthony M Gamboa, Sarah L Cristofaro, Steven A Keilin, Qiang Cai, Field F Willingham
Background and study aims Localized approaches are being increasingly used in the management of early gastric adenocarcinoma; however, there are limited data on lymph node metastasis in the US population. This study examined the incidence and predictors of lymph node involvement for early-stage gastric adenocarcinomas in the USA. Patients and methods Data were abstracted from the national SEER database from 2004 to 2013. Exclusion criteria included: cases with unknown tumor characteristics, unknown patient characteristics, metastatic disease, neoadjuvant radiation, and lack of surgical resection or lymph node evaluation...
December 11, 2017: Endoscopy
https://www.readbyqxmd.com/read/29228395/brain-stem-cavernous-malformations-operative-nuances-of-a-less-invasive-resection-technique
#7
Harminder Singh, Turki Elarjani, Harley Brito da Silva, Rakshith Shetty, Louis Kim, Laligam N Sekhar
BACKGROUND: Different operative techniques are reported for the resection of brainstem cavernous malformations (BSCMs). The senior author has previously reported on a less-invasive technique of entering the brain stem with piecemeal removal of BSCMs, especially the deep-seated ones. OBJECTIVE: To present a larger series of these lesions, emphasizing the approach to the brain stem via case selection. We discuss the nuances of the less-invasive operative technique through case illustrations and intraoperative videos...
December 8, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29228389/high-resolution-melting-analysis-a-novel-approach-for-clade-differentiation-in-pythium-insidiosum-and-pythiosis
#8
Navaporn Worasilchai, Nitipong Permpalung, Ariya Chindamporn
Pythium insidiosum causes life-threatening human pythiosis. Based on phylogenetic analysis using internal transcribed spacer (ITS) region, mitochondrial cytochrome C oxidase II (COX2) gene, intergenic spacer (IGS) region and exo-1,3-β-glucanase gene (exo1), P. insidiosum is classified into clade ATH, BTH, and CTH related to geographic distribution. At present, polymerase chain reaction in any of these specific regions with DNA sequencing is the only technique to provide clade diagnosis. In this study, P. insidiosum-specific primers targeting COX2 gene were designed and used in real-time quantitative polymerase chain reaction (qPCR) with subsequent high-resolution melting (HRM) to provide rapid identification as well as clade classification for P...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228334/clinical-and-epidemiological-characterization-of-histoplasmosis-cases-in-a-nonendemic-area-connecticut-united-states
#9
Marwan M Azar, Xuchen Zhang, Roland Assi, Chadi Hage, L Joseph Wheat, Maricar F Malinis
We performed a retrospective analysis of histoplasmosis cases diagnosed at our institution in New Haven, Connecticut, from 2005 to 2015. Among 12 cases of active histoplasmosis, seven were immunosuppressed and five had human immunodeficiency virus (HIV). Eleven patients reported travel to potentially endemic areas at a median of 105 days prior to presentation; travel to the Caribbean was most common (n = 6). Median time to diagnosis from symptom onset and first Histoplasma antigen testing were 41 and 28 days, respectively...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228280/new-intronic-fibroblast-growth-factor-receptor-1-fgfr1-mutation-leading-to-disrupted-splicing-and-kallmann-syndrome
#10
J Känsäkoski, K Vaaralahti, T Raivio
Congenital hypogonadotropic hypogonadism (CHH), which can present with a defective sense of smell (Kallmann syndrome, KS), is a clinically and genetically heterogeneous disorder. Over 31 genes have been associated with CHH, but most of the patients still lack a molecular genetic diagnosis. Some cases may be explained by mutations that disrupt the splicing of already established CHH genes but that are unrecognized either because they are located deep in introns or are not predicted to disrupt splicing. Here we identified a patient with a previously unreported Fibroblast Growth Factor Receptor 1 (FGFR1) mutation, c...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29228090/epstein-barr-virus-positive-extranodal-marginal-zone-lymphoma-of-bronchial-associated-lymphoid-tissue-in-the-posttransplant-setting-an-immunodeficiency-related-posttransplant-lymphoproliferative-disorder
#11
Daniel P Cassidy, Francisco Vega, Jennifer R Chapman
Objectives: Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are excluded from the category of PTLD in the current World Health Organization classification. Methods: We report a case of Epstein-Barr virus (EBV)-positive bronchial-associated lymphoid tissue (BALT) lymphoma involving the lungs of a transplant patient...
December 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29228083/low-po2-contributes-to-potential-error-in-oxygen-saturation-calculations-using-a-point-of-care-assay
#12
Ian L Gunsolus, Sara A Love, Louis P Kohl, Martin Schmidt, Fred S Apple
Objectives: The present study addressed the accuracy of calculated oxygen saturation (sO2) using point-of-care (POC) testing compared with measured values on a blood gas analyzer. Methods: In total, 3,323 sO2 values were measured in 1,180 patients using a CO-oximeter (ABL 800 Flex; Radiometer, Copenhagen, Denmark). Measured parameters were then used to calculate an expected sO2 for the POC method (Abbott i-STAT; Abbott POC, Princeton, NJ). Cases in which calculated sO2 differed from measured sO2 by 10% or more were analyzed...
December 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29228056/back-and-neck-pain-and-function-in-females-with-adolescent-idiopathic-scoliosis-a-follow-up-at-least-23-years-after-conservative-treatment-with-a-milwaukee-brace
#13
Ewa Misterska, Jakub Głowacki, Adam Okręt, Maria Laurentowska, Maciej Głowacki
We aimed to explore the long-term outcomes of back and neck pain and functionality in adult females with adolescent idiopathic scoliosis (AIS), who had been treated with a Milwaukee brace, in a follow-up study a minimum of 23 years after the completion of the treatment, using radiological, clinical and socio-demographical data. Thirty AIS patients (scoliosis group-SG), were included in the study based on an extensive search of Pediatric Orthopedics and Traumatology Clinic charts. All treatments were successfully completed between 1974 and 1990...
2017: PloS One
https://www.readbyqxmd.com/read/29227940/use-of-magnetic-biochars-for-the-immobilization-of-heavy-metals-in-a-multi-contaminated-soil
#14
H P Lu, Z A Li, G Gascó, A Méndez, Y Shen, J Paz-Ferreiro
Modified biochars, including magnetic biochars, have been tested in water for the removal of inorganic pollutants. However, at present it is unknown if they possess benefits over conventional biochar materials in relation to land remediation. A paddy soil was collected near Liantang village in Lechang Pb-Zn mine area in Guangdong Province (China). The soil was polluted with Cd, Cu, Zn and Pb, with total contents of 1.4mg/kg, 80mg/kg, 1638mg/kg and 2463mg/kg, respectively. We prepared magnetic and conventional biochar from two feedstocks (poultry litter and Eucalyptus) at a temperature of 300 and 500°C...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227919/a-subject-specific-biomechanical-control-model-for-the-prediction-of-cervical-spine-muscle-forces
#15
Maxim Van den Abbeele, Fan Li, Vincent Pomero, Dominique Bonneau, Baptiste Sandoz, Sébastien Laporte, Wafa Skalli
BACKGROUND: The aim of the present study is to propose a subject-specific biomechanical control model for the estimation of active cervical spine muscle forces. METHODS: The proprioception-based regulation model developed by Pomero et al. (2004) for the lumbar spine was adapted to the cervical spine. The model assumption is that the control strategy drives muscular activation to maintain the spinal joint load below the physiological threshold, thus avoiding excessive intervertebral displacements...
December 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29227899/cardiac-troponins-and-nt-probnp-in-the-forensic-setting-overview-of-sampling-site-postmortem-interval-cardiopulmonary-resuscitation-and-review-of-the-literature
#16
Cristian Palmiere, Camilla Tettamanti, Alessandro Bonsignore, Francesco De Stefano, Jessica Vanhaebost, Guillaume Rousseau, Maria Pia Scarpelli, Daniel Bardy
The possible use of biochemical markers in the postmortem diagnosis of myocardial ischemia is well known in the forensic setting, though several issues have limited its widespread adoption. The study presented herein focuses of N-terminal pro-B-type natriuretic peptide, troponin T, and troponin I, and the possible influence due to sampling site chosen, postmortem interval elapsed, and cardiopulmonary resuscitation attempts. Comparisons were performed between antemortem serum levels of these markers and postmortem levels measured in pericardial fluid and postmortem serum samples obtained from different sampling sites (n=16)...
November 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29227893/targeted-eco-pharmacovigilance-for-ketoprofen-in-the-environment-need-strategy-and-challenge
#17
REVIEW
Jun Wang, Shu-Qi Zhao, Meng-Ya Zhang, Bing-Shu He
Implementing "targeted" eco-pharmacovigilance(EPV) which focuses on individual or specific pharmaceuticals on a prioritised basis is a feasible, economical and customized approach to reduce the environmental concentrations and risks of pharmaceuticals. Non-steroidal anti-inflammatory drugs(NSAIDs) remaining in environment are a kind of priority hazard substances, due to a notable case that diclofenac residues caused the loss of more than 99% of vultures across the Indian sub-continent. Ketoprofen, as another widely used NSAID with comparable or even higher global consumption than diclofenac, in the environment has been shown to present a potential risk to non-target terrestrial and aquatic species...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29227874/selecting-passive-dosimetry-technologies-for-measuring-the-external-dose-of-terrestrial-wildlife
#18
REVIEW
Phakphum Aramrun, Nicholas A Beresford, Michael D Wood
Dosimeters attached to wild animals can be used to validate regulatory assessment approaches and models for estimating radiation exposure of wild animals. Such measurements are also necessary to ensure that robust dose-effect relationships can be developed from the results of field research programmes. This paper presents the first comprehensive evaluation of the different dosimetry technologies available for specifically measuring the external exposure of wildlife. Guidance is provided on the selection of appropriate passive dosimetry approaches for directly measuring external exposure of terrestrial wildlife under field conditions...
December 8, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#19
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227856/gastroduodenal-artery-aneurysm-post-traumatic-pancreatic-pseudocyst-drainage-an-interesting-case
#20
Mohammad Zarin, Sajid Ali, Abdul Majid, ZakaUllah Jan
BACKGROUND AND AIM: Pseudoaneurysms of the gastroduodenal artery (GDA) are rare and mostly associated with pancreatitis. However, they can occur as a possible complication following gastric or pancreatic surgery and thus prior recognition and prompt treatment is mandatory (Lee et al., 2009 [1]). We report a case of a ruptured GDA aneurysm in a patient who underwent roux-en-y-cystojejunostomy for traumatic pancreatic pseudocyst and this has rarely been reported in the literature. Our patient presented with melena one month post operatively...
December 6, 2017: International Journal of Surgery Case Reports
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