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Cristian Abelairas-Gómez, Candela Gómez-González, Roberto Barcala-Furelos, Antonio Rodríguez-Núñez
No abstract text is available yet for this article.
May 15, 2017: American Journal of Emergency Medicine
Nikolas H Kazmers, Joshua C Rozell, Kevin M Rumball, Scott H Kozin, Dan A Zlotolow, L Scott Levin
Avascular necrosis (AVN) of the capitate is a rare clinical entity for which a variety of treatment options have been described, ranging from immobilization to microvascular bone transfer. Outcomes following medial femoral condyle corticocancellous free flap reconstruction have not been reported for this specific pathology. We present the case of a 16-year-old girl with posttraumatic capitate AVN who was treated with curettage and medial femoral condyle corticocancellous vascularized bone grafting. At 18 months after surgery, the patient remains pain-free and had resumed all activities including lifeguarding by 6 months after surgery...
May 9, 2017: Journal of Hand Surgery
Guia Carrara, Maddy Parsons, Nuno Saraiva, Geoffrey L Smith
Golgi anti-apoptotic protein (GAAP), also known as transmembrane Bax inhibitor-1 motif-containing 4 (TMBIM4) or Lifeguard 4 (Lfg4), shares remarkable amino acid conservation with orthologues throughout eukaryotes, prokaryotes and some orthopoxviruses, suggesting a highly conserved function. GAAPs regulate Ca(2+) levels and fluxes from the Golgi and endoplasmic reticulum, confer resistance to a broad range of apoptotic stimuli, promote cell adhesion and migration via the activation of store-operated Ca(2+) entry, are essential for the viability of human cells, and affect orthopoxvirus virulence...
May 2017: Open Biology
Viktor Maurer, Kerstin Reimers, Hans J Lück, Peter M Vogt, Vesna Bucan
The aim of the present study was to use an enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of Lifeguard (LFG) protein in the serum of 36 patients diagnosed with breast cancer and to compare these values with the concentrations of LFG protein in the serum of 7 healthy volunteers in order to detect a possible association between the expression of LFG in the serum and the degree of malignancy of the disease. Although there is no direct association between the LFG protein concentration in the serum and the degree of malignancy of breast cancer, a statistically significant distribution of the concentration in all investigated samples was observed...
March 2017: Oncology Letters
Kevin M Ryan, Alan H Breaud, Laura Eliseo, Ralph Goto, Patricia Mitchell
Research on workplace injuries and exposures in ocean safety personnel remains limited. Despite increasing beach attendance and reliance on lifeguards for protection, the most common types of injuries, equipment resulting in injuries, and environmental exposures remains unknown. This study reviewed OSHA 300 logs summarizing workers' compensation claims from 2007-2012 to identify common body parts injured, action at time of injury, equipment causing injury, and environmental exposures. A secondary phase consisted of a cross-sectional anonymous survey to determine demographics, body part injured, equipment causing injury, sun and environmental exposures, action at time of injury, and proportion of injuries reported to the department...
July 2017: Journal of Occupational and Environmental Hygiene
Joanna Shi-En Chan, Marie Xin Ru Ng, Yih Yng Ng
INTRODUCTION: This study was a descriptive analysis of national ambulance case records, aimed at making practical safety recommendations in order to reduce the incidence of drowning in swimming pools. METHODS: A search was performed on a national database of descriptive summaries by first responder paramedics of all 995 calls made to the Singapore Civil Defence Force between 1 January 2012 and 31 December 2014. We included all cases of submersion in both public and private pools for which emergency medical services were activated...
April 3, 2017: Singapore Medical Journal
Roberto Barcala-Furelos, Cristian Abelairas-Gomez, Jose Palacios-Aguilar, Ezequiel Rey, Javier Costas-Veiga, Sergio Lopez-Garcia, Antonio Rodriguez-Nunez
PURPOSE: Drowning is a high-priority public health problem around the world. The European Resuscitation Council Guidelines for Resuscitation 2015 put special emphasis on special environments like open waters. Stopping the drowning process as soon as possible and starting an early cardiopulmonary resuscitation (CPR) improve survival. Inflatable rescue boats (IRBs) are used around the world in the water rescue of drowning victims. Our objective was to test the quality of CPR performed by surf-lifeguards while sailing on an IRB...
January 27, 2017: Emergency Medicine Journal: EMJ
A Claesson, L Svensson, P Nordberg, M Ringh, M Rosenqvist, T Djarv, J Samuelsson, O Hernborg, P Dahlbom, A Jansson, J Hollenberg
BACKGROUND: Drowning leading to out-of-hospital cardiac arrest (OHCA) and death is a major public health concern. Submersion with duration of less than 10min is associated with favorable neurological outcome and nearby bystanders play a considerable role in rescue and resuscitation. Drones can provide a visual overview of an accident scene, their potential as lifesaving tools in drowning has not been evaluated. AIM: The aim of this simulation study was to evaluate the efficiency of a drone for providing earlier location of a submerged possible drowning victim in comparison with standard procedure...
May 2017: Resuscitation
P G M'Angale, B E Staveley
Lifeguard is an integral transmembrane protein that modulates FasL-mediated apoptosis by interfering with the activation of caspase 8. It is evolutionarily conserved, with homologues present in plants, nematodes, zebra fish, frog, chicken, mouse, monkey, and human. The Lifeguard homologue in Drosophila, CG3814, contains the Bax inhibitor-1 family motif of unknown function. Downregulation of Lifeguard disrupts cellular homeostasis and disease by sensitizing neurons to FasL-mediated apoptosis. We used bioinformatic analyses to identify CG3814, a putative homologue of Lifeguard, and knocked down CG3814/LFG expression under the control of the Dopa decarboxylase (Ddc-Gal4) transgene in Drosophila melanogaster neurons to investigate whether it possesses neuroprotective activity...
December 19, 2016: Genetics and Molecular Research: GMR
Ana Sousa, Ricardo J Fernandes, Núria Rodríguez, J Arturo Abraldes
OBJECTIVE: Cardiopulmonary resuscitation (CPR) after a drowning episode is performed under fatigue conditions. However, the characterization of CPR in this context is still unknown. Our purpose was to investigate the effect of a 100-m simulated in-water rescue on CPR and physiological parameters in trained certified lifeguards. METHODS: Thirty trained certified lifeguards (age 24.6 ± 3.8 yrs; height 178.2 ± 7.4 cm and weight 76.9 ± 10.6 kg) completed two protocols using an adult manikin: (i) 4-min CPR after 4-min baseline conditions (CPR), and (ii) 4-min CPR after a 100-m simulated in-water rescue in the sea (CPR Rescue), both with a compression-ventilation ratio of 30:2...
May 2017: Prehospital Emergency Care
Élie Vignac, Pascal Lebihain, Bastien Soulé
To prevent drowning incidents in French public swimming pools (PSP), bathing must be constantly supervised by qualified lifeguards. However, fatal drownings regularly occurs in supervised aquatic facilities, calling into question the efficacy of the supervision chain. The aim of this research is to fully assess the periods during which supervision is not carried out, or carried out in an inadequate manner. The observations made in 108 French PSP show that constant supervision, as stipulated by regulations, represents only half of the time...
July 18, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Rachel J Marchalik, Suraj Venna
An 87-year-old man presented for treatment of a stye on his left upper eyelid. Despite conservative interventions, the stye had persisted and the skin had become noticeably darker over several weeks (Panels A and B). He reported itching but no pain or bleeding. His risk factors for skin cancer..
July 7, 2016: New England Journal of Medicine
Masood Ali Shaikh
Karachi Municipal Corporation's Emergency Response Center's lifeguards save drowning individuals, recover dead bodies of drowned individuals, and provide first aid care to injured victims of near-drowning and road traffic accidents on the road along the various beaches.Cumulatively302 drowning and near-drowning 302 incidents were recorded from 2012 to 2014, with 291 (96.3%) incidents involving males. One hundred ninety-six (64.9%) individuals were saved from drowning, out of which 116 (59.2%) were saved on Sundays, followed by 31 (15...
May 2016: JPMA. the Journal of the Pakistan Medical Association
Daniel Radin, Arnold Lippa, Parth Patel, Donna Leonardi
Triple-negative breast cancer does not express estrogen receptor-α, progesterone or the HER2 receptor making hormone or antibody therapy ineffective. Cisplatin may initiate p73-dependent apoptosis in p53 mutant cell lines through Fas trimerization and Caspase-8 activation and Bax up regulation and subsequent Caspase-9 activation. The triple-negative breast cancer, MDA-MB-231, overexpresses the protein Lifeguard, which inhibits Fas-mediated apoptosis by inhibiting Caspase-8 activation after Fas trimerization...
February 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Roberto Barcala-Furelos, David Szpilman, Jose Palacios-Aguilar, Javier Costas-Veiga, Cristian Abelairas-Gomez, Antonio Bores-Cerezal, Sergio López-García, Antonio Rodríguez-Nuñez
PURPOSE: The whole drowning process usually occurs within seconds to a few minutes. An early rescue may stop and/or prevent most medical complications. Fins, rescue tube, and rescue board (RB) are the equipment most frequently used by lifeguards. Our objective was to compare, in a water rescue quasiexperimental trial, these different pieces of rescue equipment to define the safest and with the lower rescue time as well as to assess their effects on the lifeguards' physiological state and cardiopulmonary resuscitation (CPR) performance...
March 2016: American Journal of Emergency Medicine
Jose A Prieto, Paloma Nistal, David Méndez, Cristian Abelairas-Gomez, Roberto Barcala-Furelos
INTRODUCTION: The strong physical demands that are required of lifeguards during rescues also require an accurate self-perception of one's fitness level to be able to regulate the intensity of effort. OBJECTIVES: The aim of this study was to determine the real aerobic capacity (RAC) and to compare it with two self-reported measurements: subjective appraisal of aerobic capacity (SAAC) and appraisal of physical exercise (APE). METHODS: Fifty-two professional lifeguards were included in the study...
2016: International Journal of Occupational Safety and Ergonomics: JOSE
Jorge Urresti, Marisol Ruiz-Meana, Elena Coccia, Juan Carlos Arévalo, José Castellano, Celia Fernández-Sanz, Koen M O Galenkamp, Laura Planells-Ferrer, Rana S Moubarak, Núria Llecha-Cano, Stéphanie Reix, David García-Dorado, Bruna Barneda-Zahonero, Joan X Comella
Death receptors are members of the tumor necrosis factor receptor superfamily involved in the extrinsic apoptotic pathway. Lifeguard (LFG) is a death receptor antagonist mainly expressed in the nervous system that specifically blocks Fas ligand (FasL)-induced apoptosis. To investigate its mechanism of action, we studied its subcellular localization and its interaction with members of the Bcl-2 family proteins. We performed an analysis of LFG subcellular localization in murine cortical neurons and found that LFG localizes mainly to the ER and Golgi...
January 15, 2016: Journal of Biological Chemistry
Tatiana Hurtado de Mendoza, Fei Liu, Inder M Verma
Anti-apoptotic protein Lifeguard (LFG) is upregulated on T cells upon in vitro activation. To investigate its role in T cell immunity we infected wild type and LFG knockout bone marrow chimaeras mice with LCMV. We observed a decreased number of LFG KO activated CD8 and CD4 T cells throughout the infection and a marked decrease in LFG KO LCMV specific memory T cells. WT and KO T cells proliferated at the same rate, however, LFG KO CD44(hi) T cells showed increased cell death during the initial phase of the immune response...
2015: PloS One
Dawn A Shively, Meredith B Nevers, Cathy Breitenbach, Mantha S Phanikumar, Kasia Przybyla-Kelly, Ashley M Spoljaric, Richard L Whitman
Predictive empirical modeling is used in many locations worldwide as a rapid, alternative recreational water quality management tool to eliminate delayed notifications associated with traditional fecal indicator bacteria (FIB) culturing (referred to as the persistence model, PM) and to prevent errors in releasing swimming advisories. The goal of this study was to develop a fully automated water quality management system for multiple beaches using predictive empirical models (EM) and state-of-the-art technology...
January 15, 2016: Journal of Environmental Management
Judith Müller, Viktor Maurer, Kerstin Reimers, Peter M Vogt, Vesna Bucan
Lifeguard (LFG) is a transmembrane protein which is highly expressed in tissues of the hippocampus and the cerebellum, especially during postnatal development. This protein is responsible for the protection of neurons against Fas-induced apoptosis, and the same effect can be seen in tumor cells derived from mastocarcinoma. However, the molecular function of LFG and its regulation in the carcinogenesis of human breast cells remains to be elucidated. In the present study, we investigated the connection of the interaction of LFG within an array analysis of over 9,000 different proteins...
November 2015: International Journal of Oncology
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