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Élie Vignac, Pascal Lebihain, Bastien Soulé
To prevent drowning incidents in French public swimming pools (PSP), bathing must be constantly supervised by qualified lifeguards. However, fatal drownings regularly occurs in supervised aquatic facilities, calling into question the efficacy of the supervision chain. The aim of this research is to fully assess the periods during which supervision is not carried out, or carried out in an inadequate manner. The observations made in 108 French PSP show that constant supervision, as stipulated by regulations, represents only half of the time...
July 18, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Rachel J Marchalik, Suraj Venna
An 87-year-old man presented for treatment of a stye on his left upper eyelid. Despite conservative interventions, the stye had persisted and the skin had become noticeably darker over several weeks (Panels A and B). He reported itching but no pain or bleeding. His risk factors for skin cancer..
July 7, 2016: New England Journal of Medicine
Masood Ali Shaikh
Karachi Municipal Corporation's Emergency Response Center's lifeguards save drowning individuals, recover dead bodies of drowned individuals, and provide first aid care to injured victims of near-drowning and road traffic accidents on the road along the various beaches.Cumulatively302 drowning and near-drowning 302 incidents were recorded from 2012 to 2014, with 291 (96.3%) incidents involving males. One hundred ninety-six (64.9%) individuals were saved from drowning, out of which 116 (59.2%) were saved on Sundays, followed by 31 (15...
May 2016: JPMA. the Journal of the Pakistan Medical Association
Daniel Radin, Arnold Lippa, Parth Patel, Donna Leonardi
Triple-negative breast cancer does not express estrogen receptor-α, progesterone or the HER2 receptor making hormone or antibody therapy ineffective. Cisplatin may initiate p73-dependent apoptosis in p53 mutant cell lines through Fas trimerization and Caspase-8 activation and Bax up regulation and subsequent Caspase-9 activation. The triple-negative breast cancer, MDA-MB-231, overexpresses the protein Lifeguard, which inhibits Fas-mediated apoptosis by inhibiting Caspase-8 activation after Fas trimerization...
February 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Roberto Barcala-Furelos, David Szpilman, Jose Palacios-Aguilar, Javier Costas-Veiga, Cristian Abelairas-Gomez, Antonio Bores-Cerezal, Sergio López-García, Antonio Rodríguez-Nuñez
PURPOSE: The whole drowning process usually occurs within seconds to a few minutes. An early rescue may stop and/or prevent most medical complications. Fins, rescue tube, and rescue board (RB) are the equipment most frequently used by lifeguards. Our objective was to compare, in a water rescue quasiexperimental trial, these different pieces of rescue equipment to define the safest and with the lower rescue time as well as to assess their effects on the lifeguards' physiological state and cardiopulmonary resuscitation (CPR) performance...
March 2016: American Journal of Emergency Medicine
Jose A Prieto, Paloma Nistal, David Méndez, Cristian Abelairas-Gomez, Roberto Barcala-Furelos
INTRODUCTION: The strong physical demands that are required of lifeguards during rescues also require an accurate self-perception of one's fitness level to be able to regulate the intensity of effort. OBJECTIVES: The aim of this study was to determine the real aerobic capacity (RAC) and to compare it with two self-reported measurements: subjective appraisal of aerobic capacity (SAAC) and appraisal of physical exercise (APE). METHODS: Fifty-two professional lifeguards were included in the study...
2016: International Journal of Occupational Safety and Ergonomics: JOSE
Jorge Urresti, Marisol Ruiz-Meana, Elena Coccia, Juan Carlos Arévalo, José Castellano, Celia Fernández-Sanz, Koen M O Galenkamp, Laura Planells-Ferrer, Rana S Moubarak, Núria Llecha-Cano, Stéphanie Reix, David García-Dorado, Bruna Barneda-Zahonero, Joan X Comella
Death receptors are members of the tumor necrosis factor receptor superfamily involved in the extrinsic apoptotic pathway. Lifeguard (LFG) is a death receptor antagonist mainly expressed in the nervous system that specifically blocks Fas ligand (FasL)-induced apoptosis. To investigate its mechanism of action, we studied its subcellular localization and its interaction with members of the Bcl-2 family proteins. We performed an analysis of LFG subcellular localization in murine cortical neurons and found that LFG localizes mainly to the ER and Golgi...
January 15, 2016: Journal of Biological Chemistry
Tatiana Hurtado de Mendoza, Fei Liu, Inder M Verma
Anti-apoptotic protein Lifeguard (LFG) is upregulated on T cells upon in vitro activation. To investigate its role in T cell immunity we infected wild type and LFG knockout bone marrow chimaeras mice with LCMV. We observed a decreased number of LFG KO activated CD8 and CD4 T cells throughout the infection and a marked decrease in LFG KO LCMV specific memory T cells. WT and KO T cells proliferated at the same rate, however, LFG KO CD44(hi) T cells showed increased cell death during the initial phase of the immune response...
2015: PloS One
Dawn A Shively, Meredith B Nevers, Cathy Breitenbach, Mantha S Phanikumar, Kasia Przybyla-Kelly, Ashley M Spoljaric, Richard L Whitman
Predictive empirical modeling is used in many locations worldwide as a rapid, alternative recreational water quality management tool to eliminate delayed notifications associated with traditional fecal indicator bacteria (FIB) culturing (referred to as the persistence model, PM) and to prevent errors in releasing swimming advisories. The goal of this study was to develop a fully automated water quality management system for multiple beaches using predictive empirical models (EM) and state-of-the-art technology...
January 15, 2016: Journal of Environmental Management
Judith Müller, Viktor Maurer, Kerstin Reimers, Peter M Vogt, Vesna Bucan
Lifeguard (LFG) is a transmembrane protein which is highly expressed in tissues of the hippocampus and the cerebellum, especially during postnatal development. This protein is responsible for the protection of neurons against Fas-induced apoptosis, and the same effect can be seen in tumor cells derived from mastocarcinoma. However, the molecular function of LFG and its regulation in the carcinogenesis of human breast cells remains to be elucidated. In the present study, we investigated the connection of the interaction of LFG within an array analysis of over 9,000 different proteins...
November 2015: International Journal of Oncology
Olivia Cheung, Alfonso Caramazza
What are the factors that determine how objects are represented in the visual system? Apart from visual shape, conceptual information such as animacy and object size has been established as major organizational principles for object representations in the occipito-temporal cortex. However, it remains unclear whether object representations may also be influenced by contextual information (i.e., where objects appear in the world). There has been debate regarding whether contextual information is retrieved when objects are seen, and whether the neural locus of contextual effect may be in the object-selective lateral occipital complex (LOC) or the scene-selective parahippocampal cortex (PHC)...
2015: Journal of Vision
Mathieu C Morissette, Nicolas Murray, Julie Turmel, Julie Milot, Louis-Philippe Boulet, Valérie Bougault
OBJECTIVES: This study aimed to evaluate the levels of 8-isoprostane (8-IsoP) in the airways of competitive swimmers at baseline and after a swimming session according to their airway responsiveness. METHODS: Twenty-three swimmers and six lifeguards had a baseline spirometry and bronchoprovocative challenges. During a second visit, swimmers performed a usual swimming session while lifeguards stayed in the same pool environment for the same time period. Forced expiratory volume in one second (FEV1) was measured before and 5 min after the end of the session...
August 2016: European Journal of Sport Science
Flore Kruiswijk, Christiaan F Labuschagne, Karen H Vousden
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates various metabolic pathways, helping to balance glycolysis and oxidative phosphorylation, limiting the production of reactive oxygen species, and contributing to the ability of cells to adapt to and survive mild metabolic stresses. Although these activities may be integrated into the tumour suppressive functions of p53, deregulation of some elements of the p53-induced response might also provide tumours with a survival advantage...
July 2015: Nature Reviews. Molecular Cell Biology
Anna Attard, Robert W Brander, Wendy S Shaw
This study describes the demographics, occurrence, location, primary hazards and outcomes involved in rescues performed by surfers on Australian beaches. Conservative estimates suggest that the number of rescues conducted by Australian surfers each year is on par with the number conducted by volunteer surf lifesavers. Surfers perform a considerable number of serious rescues in both lifesaver/lifeguard patrolled (45%) and unpatrolled (53%) beach locations. Rip currents represent the major physical hazard leading to rescue (75%) and the dominant emotional response of people rescued is one of panic (85%)...
September 2015: Accident; Analysis and Prevention
Yannick P Lungwitz, Benedikt L Nussbaum, Klaus Paulat, Claus-Martin Muth, Peter Kranke, Bernd E Winkler
BACKGROUND: In-water resuscitation (IWR) is recommended in the 2010 guidelines of the European Resuscitation Council. As IWR represents a physical challenge to the rescuer, a novel Rescue Tube device with an integrated "Oxylator" resuscitator might facilitate IWR. The aim of the present study was the assessment of IWR using the novel Rescue Tube device. METHODS: Tidal and minute volumes were recorded using a modified Laerdal Resusci Anne mannequin. Furthermore, rescue time, water aspiration, submersions, and physical exertion were assessed...
April 2015: Aerospace Medicine and Human Performance
Peter Iserbyt, Gilles Schouppe, Nathalie Charlier
BACKGROUND: Research investigating lifeguards' performance of Basic Life Support (BLS) with Automated External Defibrillator (AED) is limited. AIM: Assessing simulated BLS/AED performance in Flemish lifeguards and identifying factors affecting this performance. METHODS: Six hundred and sixteen (217 female and 399 male) certified Flemish lifeguards (aged 16-71 years) performed BLS with an AED on a Laerdal ResusciAnne manikin simulating an adult victim of drowning...
April 2015: Resuscitation
Kevin Moran, Jonathon Webber
Aims: In spite of the popularity of beaches for family recreation, little is known about childhood injuries sustained at beaches. It is the purpose of this study to analyse data from incidents necessitating first aid treatment from reports compiled by surf lifeguards on New Zealand beaches.Method: A retrospective analysis of first aid incidents involving children (<16 years) was conducted using data obtained from Surf Life Saving New Zealand incident report forms during five summer seasons from 2007 to 2012...
March 2014: Journal of Paediatrics and Child Health
Kevin Moran, Jonathon Webber
Aims: In spite of the popularity of beaches for family recreation, little is known about childhood injuries sustained at beaches. It is the purpose of this study to analyse data from incidents necessitating first aid treatment from reports compiled by surf lifeguards on New Zealand beaches.Method: A retrospective analysis of first aid incidents involving children (<16 years) was conducted using data obtained from Surf Life Saving New Zealand incident report forms during five summer seasons from 2007 to 2012...
March 2014: Journal of Paediatrics and Child Health
Masood Ali Shaikh
Going to beaches is a popular pastime for many people in Karachi. Lifeguards have been deployed on many beaches for the safety and protection of beachgoers. This cross-sectional survey was conducted to study the opinions and experiences of lifeguards posted at eight beaches of Karachi. Ignorance among beachgoers about how dangerous it could be at seaside, was reported by 19 (61.3%) out of 31 lifeguards interviewed. Lifeguards had to put up with verbal and physical abuse while discharging their duties, with verbal abuse being the universal experience...
May 2014: JPMA. the Journal of the Pakistan Medical Association
L Planells-Ferrer, J Urresti, A Soriano, S Reix, D M Murphy, J C Ferreres, F Borràs, S Gallego, R L Stallings, R S Moubarak, M F Segura, J X Comella
Neuroblastoma (NBL) is the most common solid tumor in infants and accounts for 15% of all pediatric cancer deaths. Several risk factors predict NBL outcome: age at the time of diagnosis, stage, chromosome alterations and MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma-Derived Homolog) amplification, which characterizes the subset of the most aggressive NBLs with an overall survival below 30%. MYCN-amplified tumors develop exceptional chemoresistance and metastatic capacity. These properties have been linked to defects in the apoptotic machinery, either by silencing components of the extrinsic apoptotic pathway (e...
2014: Cell Death & Disease
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