Zeng Ye, Haidi Chen, Shunrong Ji, Yuheng Hu, Xin Lou, Wuhu Zhang, Desheng Jing, Guixiong Fan, Yue Zhang, Xuemin Chen, Qifeng Zhuo, Jie Chen, Xiaowu Xu, Xianjun Yu, Jin Xu, Yi Qin, Heli Gao
Pancreatic neuroendocrine tumor (pNET) is the second most common malignant tumors of the pancreas. Multiple endocrine neoplasia 1 ( MEN1 ) is the most frequently mutated gene in pNETs and MEN1-encoded protein, menin, is a scaffold protein that interacts with transcription factors and chromatin-modifying proteins to regulate various signaling pathways. However, the role of MEN1 in lipid metabolism has not been studied in pNETs. In this study, we perform targeted metabolomics analysis and find that MEN1 promotes the generation and oxidation of polyunsaturated fat acids (PUFAs)...
November 25, 2022: Acta Biochimica et Biophysica Sinica