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Hypoalbuminemia

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https://www.readbyqxmd.com/read/29035910/new-predictive-factors-of-poor-response-to-therapy-in-autoimmune-hepatitis-role-of-mean-platelet-volume
#1
Ahmed Abdel-Razik, Nasser Mousa, Sahar Zakaria, Rania Elhelaly, Rasha Elzehery, Khaled Zalata, Mahmoud Awad, Ahmed A Eldeeb, Mostafa Abdelsalam
BACKGROUND AND OBJECTIVES: The response to immunosuppressive therapy in autoimmune hepatitis (AIH) is a matter of debate. The aim of this work is to identify the histological, biochemical, and clinical predictive factors of incomplete response/treatment failure to the standard treatment (prednisone with or without azathioprine) in a well-characterized series of AIH Egyptian patients. PATIENTS AND METHODS: Of 49 AIH patients, only 36 patients completed this retrospective cohort study...
October 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29034746/clinical-characteristics-of-acute-fatty-liver-of-pregnancy-in-a-tertiary-indonesian-hospital
#2
Muhammad Ilham Aldika Akbar, Indah Mayang Sari, Aditiawarman, Erry Gumilar Dachlan, Gustaaf Dekker
Acute fatty liver of pregnancy (AFLP) is a rare, often autosomal recessive disorder with a major risk for maternal and perinatal mortality and morbidity. In order to achieve a more favorable outcome, awareness of its clinical signs and symptoms and early recognition are of pivotal importance. Over a 5-year period 18 patients were diagnosed with AFLP (one twin, 19 babies). The most common sign and symptoms were jaundice, hypoglycemia, nausea and vomiting, encephalopathy, and hypertension. Abnormal laboratory test results included: elevated total/ conjugated (direct) bilirubin, AST, ALT, PT, APTT, creatinine, leukocyte count, and hypoalbuminemia...
October 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29033425/evaluation-by-mr-enterocolonography-of-lansoprazole-induced-collagenous-colitis-accompanied-with-protein-losing-enteropathy-a-case-report
#3
Akinori Mizoguchi, Masaaki Higashiyama, Keisuke Ikeyama, Shin Nishii, Hisato Terada, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Kazuhiko Shirakabe, Chikako Watanabe, Kengo Tomita, Shunsuke Komoto, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
We herein describe a 69-year-old man suffering from chronic diarrhea caused by lansoprazole (LPZ)-induced collagenous colitis (CC) accompanied with protein-losing enteropathy (PLE), diagnosed by increased fecal alpha-1 antitrypsin clearance and the findings of leakage from the descending colon to the sigmoid colon on scintigraphy. MR enterocolonography (MREC) was also performed for differentiating digestive diseases, and inflamed findings were observed around the same portion as those on scintigraphy, suggesting that this region was responsible for protein loss in this case...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29032266/hypoalbuminemia-at-day-90-is-associated-with-inferior-non-relapse-mortality-and-overall-survival-in-allogeneic-hct-recipients-a-confirmatory-study
#4
Hemant S Murthy, Kyle Sheets, Ambuj Kumar, Taiga Nishihori, Alain Mina, Julio C Chavez, Ernesto Ayala, Teresa Field, John Mathews, Frederick Locke, Lia Perez, Brian C Betts, Farhad Khimani, Branco Miladinovic, Athanasios Tsalatsanis, Jose Leonel Ochoa-Bayona, Melissa Alsina, Hugo Fernandez, Joseph Pidala, Claudio Anasetti, Mohamed A Kharfan-Dabaja
Prognostic biomarkers in allogeneic hematopoietic cell transplantation are needed to improve risk assessment and help guide therapeutic and surveillance strategies to mitigate the risk of death from the procedure. We previously identified hypoalbuminemia at day +90 post-transplantation as an independent predictor of increased non-relapse mortality and inferior overall survival in patients with acute myelogenous leukemia and myelodysplastic syndrome who were treated with an allogeneic hematopoietic cell transplant...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29031355/adverse-effects-of-the-metabolic-acidosis-of-chronic-kidney-disease
#5
REVIEW
Jeffrey A Kraut, Nicolaos E Madias
The kidney has the principal role in the maintenance of acid-base balance, and therefore, a fall in renal net acid excretion and positive H(+) balance often leading to reduced serum [HCO3(-)] are observed in the course of CKD. This metabolic acidosis can be associated with muscle wasting, development or exacerbation of bone disease, hypoalbuminemia, increased inflammation, progression of CKD, protein malnutrition, alterations in insulin, leptin, and growth hormone, and increased mortality. Importantly, some of the adverse effects can be observed even in the absence of overt hypobicarbonatemia...
September 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29029667/prediction-accuracy-of-winter-tozer-equations-to-estimate-free-phenytoin-concentrations-in-non-critically-ill-hospitalized-patients
#6
Ayesha M Khan, Marketa Marvanova
OBJECTIVE: To assess the accuracy of the standard and revised Winter-Tozer (WT) equations of predicting free phenytoin (PHT) concentrations in non-critically ill, hospitalized patients. DESIGN: Retrospective chart review. SETTING: Single-center, large urban community hospital. PATIENTS, PARTICIPANTS: Patients with free PHT levels obtained during the study period were reviewed. Thirty-nine non-critically ill, hospitalized adults met the inclusion criteria...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29029099/biomarkers-of-mineral-and-bone-metabolism-and-20-year-risk-for-hospitalization-with-infection-the-aric-study
#7
Junichi Ishigami, Bernard G Jaar, Casey M Rebholz, Morgan E Grams, Erin D Michos, Myles Wolf, Csaba P Kovesdy, Shinichi Uchida, Josef Coresh, Pamela L Lutsey, Kunihiro Matsushita
Context: Mineral and bone disorders (MBD) may be relevant in the etiology of infection. Objective: To determine whether MBD biomarkers were associated with incidence of hospitalization with infection. We also assessed the cross-sectional association between levels of MBD biomarkers and kidney function. Design: Setting, Participants: Community-based cohort study using 11,218 participants with estimated glomerular filtration rate (eGFR) ≥30 ml/min/1...
September 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29021453/severe-alcoholic-hepatitis-effectively-treated-with-vitamin-e-as-an-add-on-to-corticosteroids
#8
Yuichi Miyashima, Michihiko Shibata, Yuichi Honma, Hidehiko Matsuoka, Masaaki Hiura, Shintaro Abe, Masaru Harada
A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 10 and 54 points, respectively. We diagnosed her with severe alcoholic hepatitis and treated her with corticosteroids, but her liver function did not improve...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29016434/hypoalbuminemia-is-associated-with-septic-revisions-after-primary-surgery-and-post-operative-infection-after-revision-surgery
#9
Krishn Khanna, Paul H Yi, David C Sing, Erik Geiger, Lionel N Metz
STUDY DESIGN: Retrospective Database Review OBJECTIVE.: To determine (1) the relationship between hypoalbuminemia and body mass index (BMI); (2) the association between malnutrition and revision spine surgery for septic reasons; (3) the association between malnutrition and infection after aseptic revision spine surgery. SUMMARY OF BACKGROUND DATA: Although malnutrition has been suggested to increase the risk of infection after spine surgery, evidence supporting this hypothesis is conflicting...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/29016317/malaria-is-more-prevalent-than-iron-deficiency-among-anemic-pregnant-women-at-the-first-antenatal-visit-in-rural-south-kivu
#10
Esto Bahizire, P Lundimu Tugirimana, Michèle Dramaix, Déogratias Zozo, Mugisho Bahati, Andrew Mwale, Sylvain Meuris, Philippe Donnen
Anemia is common during pregnancy and is associated with poor outcomes. Objectives were not only 1) to determine the prevalence of anemia and iron deficiency (ID) but also 2) to identify other factors associated with anemia in pregnant women from South Kivu province, in the eastern Democratic Republic of Congo. Between December 2013 and March 2014, 531 women attending the first antenatal visit in their second trimester of pregnancy were recruited. Sociodemographic, clinical, and biological data were collected...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#11
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28984058/multivariate-analysis-of-risk-factors-for-cisplatin-induced-nephrotoxicity-in-gynecological-cancer
#12
Yoshihiro Yamamoto, Kazushi Watanabe, Hiroshi Matsushita, Ikuto Tsukiyama, Katsuhiko Matsuura, Akihiko Wakatsuki
AIM: Risk factors for cisplatin-induced nephrotoxicity (CIN) vary by population. This study aimed to assess risk factors for CIN in patients with gynecological cancer. METHODS: Patients who underwent cisplatin-based chemotherapy for gynecological cancer between January 2009 and December 2015 at Aichi Medical University School of Medicine were included in this study. CIN was defined according to the 'risk, injury, failure, loss, and end-stage kidney disease' (RIFLE) criteria and classified as either risk (Class R) or injury (Class I)...
October 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28983018/phase-1-study-of-the-anti-cd22-immunotoxin-moxetumomab-pasudotox-for-childhood-acute-lymphoblastic-leukemia
#13
MULTICENTER STUDY
Alan S Wayne, Nirali N Shah, Deepa Bhojwani, Lewis B Silverman, James A Whitlock, Maryalice Stetler-Stevenson, Weili Sun, Meina Liang, Jie Yang, Robert J Kreitman, Mark C Lanasa, Ira Pastan
Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter phase 1 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (N = 55). Moxetumomab pasudotox was administered as a 30-minute IV infusion at doses of 5 to 50 µg/kg every other day for 6 (cohorts A and B) or 10 (cohort C) doses in 21-day cycles...
October 5, 2017: Blood
https://www.readbyqxmd.com/read/28979337/investigating-the-use-of-human-albumin-in-a-non-teaching-hospital-in-iran
#14
Farzaneh Foroughinia, Shahriar Mazraie
Albumin is an expensive drug which imposes relatively high cost on the health care system. Doing ABC analysis in Shahid Motahari Hospital, it was revealed that albumin is categorized in class A. Therefore, the present study aimed to evaluate the pattern of albumin use and the physicians' adherence to evidenced-based albumin guidelines in this large general non-teaching hospital in Shiraz, Iran. This study is an observational retrospective research on drug utilization. All patients admitted to Shahid Motahari hospital that had received albumin during the study period of one year (December 2013 to December 2014), were included in the study...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28977667/successful-use-of-entecavir-in-hepatitis-b-associated-membranous-nephropathy
#15
Vidushi Mahajan, Sanjay D'Cruz, Ritambara Nada, Atul Sachdev
We report the case of a 7-year-old unimmunized boy who presented with generalized anasarca for the first time, along with nephrotic-range proteinuria, hypoalbuminemia, microscopic hematuria and hypertension. Special investigations revealed ELISA test to be positive for hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen (HBeAg); hepatitis B viral DNA load (HBV DNA) level (real-time polymerase chain reaction) was 54 360 903 IU/ml. For hepatitis B virus (HBV)-related glomerulopathy, he was started on enalapril and lasilactone, and percutaneous renal biopsy was performed, which revealed membranous nephropathy (MN)...
July 27, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28974340/a-possible-new-morphological-variant-of-mantle-cell-lymphoma-with-plasma-cell-type-castleman-disease-like-features
#16
Takuro Igawa, Rika Omote, Hiaki Sato, Kohei Taniguchi, Katsuya Miyatani, Tadashi Yoshino, Yasuharu Sato
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28965313/significant-liver-related-morbidity-after-bariatric-surgery-and-its-reversal-a-case-series
#17
Magdalena Eilenberg, Felix B Langer, Andrea Beer, Michael Trauner, Gerhard Prager, Katharina Staufer
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) occurs in up to 80% of patients with obesity. Current data suggest an improvement of NAFLD after established bariatric procedures. OBJECTIVES: This study investigated liver function impairment after Roux-en-Y gastric bypass (RYGB) and one-anastomosis gastric bypass (OAGB). SETTING: University Hospital, Bariatric Surgery Unit METHODS: In this single-center case series, consecutive in- and outpatients after bariatric surgery who presented with severe liver dysfunction from March 2014 to February 2017 were included and followed until March 2017...
September 30, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28961608/nivolumab-associated-nephrotic-syndrome-in-a-patient-with-renal-cell-carcinoma-a-case-report
#18
Robin A Daanen, Rutger J H Maas, Rutger H T Koornstra, Eric J Steenbergen, Carla M L van Herpen, Annelieke E C A B Willemsen
INTRODUCTION: Immune checkpoint inhibitors have taken an important place in the treatment of different types of malignancies. These drugs are known to have specific immune-mediated adverse events. We describe a case of severe nephrotic syndrome secondary to treatment with nivolumab in a patient with renal cell carcinoma. CASE PRESENTATION: A 62-year-old man was treated with nivolumab for papillary renal cell carcinoma type 2 for 8 weeks when he was admitted to the hospital with a severe nephrotic syndrome and acute kidney injury...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28958654/factors-associated-with-prolonged-hospitalization-in-patients-undergoing-pancreatoduodenectomy
#19
Michal Radomski, Mazen Zenati, Stephanie Novak, Vernissia Tam, Jennifer Steve, David L Bartlett, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: Complex surgeries such as a pancreatoduodenectomy (PD) traditionally have long hospital stays (LOS). METHODS: Patients who underwent elective PD at our institution from 8/2011-6/2015 were retrospectively examined. Interquartile ranges were calculated from LOS. Patient were compared between the highest quartile and the remainder of the cohort. RESULTS: 492 patients had a median LOS of 9 days, with 106 (22%) admitted for >14 days...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28954837/clinical-laboratory-and-molecular-findings-and-long-term-follow-up-data-in-96-french-patients-with-pmm2-cdg-phosphomannomutase-2-congenital-disorder-of-glycosylation-and-review-of-the-literature
#20
Manuel Schiff, Céline Roda, Marie-Lorraine Monin, Alina Arion, Magali Barth, Nathalie Bednarek, Maud Bidet, Catherine Bloch, Nathalie Boddaert, Delphine Borgel, Anaïs Brassier, Alexis Brice, Arnaud Bruneel, Roger Buissonnière, Brigitte Chabrol, Marie-Chantal Chevalier, Valérie Cormier-Daire, Claire De Barace, Emmanuel De Maistre, Anne De Saint-Martin, Nathalie Dorison, Valérie Drouin-Garraud, Thierry Dupré, Bernard Echenne, Patrick Edery, François Feillet, Isabelle Fontan, Christine Francannet, François Labarthe, Cyril Gitiaux, Delphine Héron, Marie Hully, Sylvie Lamoureux, Dominique Martin-Coignard, Cyril Mignot, Gilles Morin, Tiffany Pascreau, Olivier Pincemaille, Michel Polak, Agathe Roubertie, Christel Thauvin-Robinet, Annick Toutain, Géraldine Viot, Sandrine Vuillaumier-Barrot, Nathalie Seta, Pascale De Lonlay
BACKGROUND: Phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is a multisystem inborn error of metabolism. OBJECTIVES: To better characterise the natural history of PMM2-CDG. METHODS: Medical charts of 96 patients with PMM2-CDG (86 families, 41 males, 55 females) were retrospectively reviewed. Data on clinical, laboratory and molecular parameters at diagnosis were analysed. Follow-up data at last examination were reported for 25 patients...
September 27, 2017: Journal of Medical Genetics
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