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Hypoalbuminemia

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https://www.readbyqxmd.com/read/28430579/antiangiogenesis-and-gene-aberration-related-therapy-may-improve-overall-survival-in-patients-with-concurrent-kras-and-tp53-hotspot-mutant-cancer
#1
Zhijie Wang, Sarina Piha-Paul, Filip Janku, Vivek Subbiah, Naiyi Shi, Jing Gong, Chetna Wathoo, Kenna Shaw, Kenneth Hess, Russell Broaddus, Aung Naing, David Hong, Apostolia M Tsimberidou, Daniel Karp, James Yao, Funda Meric-Bernstam, Siqing Fu
PURPOSE: Genetic alterations such as activating KRAS and/or inactivating TP53 are thought to be the most common drivers to tumorigenesis. Therefore, we assessed phase I cancer patients with KRAS+/TP53+ mutations. RESULTS: Approximately 8% of patients referred to phase I clinical trials harbored concurrent KRAS and TP53 mutations. Patients who received a phase I trial therapy (n = 57) had a median OS of 12 months, compared with 4.6 months in those who were not treated (n = 106; p = 0...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424034/clinical-and-laboratory-factors-associated-with-mortality-in-dengue
#2
Atul Saroch, Vivek Arya, Nitin Sinha, R S Taneja, Pooja Sahai, R K Mahajan
Dengue is endemic in more than 100 countries, giving rise to an increased number of deaths in the last five years in the South-East Asian region. We report our findings from a retrospective study of adults admitted with confirmed dengue at our institution. We studied the clinical and laboratory parameters associated with mortality in these patients. Of the 172 hospitalised patients studied, 156 (90.69 %) recovered while 16 (9.3%) died. Univariate analysis showed altered sensorium on presentation, lower haemoglobin and haematocrit levels, higher serum creatinine, higher serum transaminase and lower serum albumin levels to be significantly associated with mortality in dengue...
April 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28420111/plantago-asiatica-l-ameliorates-puromycin-aminonucleoside-induced-nephrotic-syndrome-by-suppressing-inflammation-and-apoptosis
#3
Min Chul Kho, Ji Hun Park, Byung Hyuk Han, Rui Tan, Jung Joo Yoon, Hye Yoom Kim, You Mee Ahn, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
OBJECTIVE: Nephrotic syndrome, a kidney disease with a variety of causes, is mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This study was designed to evaluate the underlying mechanism of action of Plantago asiatica L. (PAL) in treating nephrotic syndrome induced by puromycin aminonucleoside. METHODS: PAL has been used in Asia as a traditional medicine and dietary health supplement. Sprague-Dawley (SD) rats were intravenously injected with puromycin aminonucleoside (75 mg/kg/day), then treated with either Losartan (30 mg/kg/day) or PAL (200 mg/kg/day) by oral gavage for seven days...
April 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28419138/clinical-significance-of-ngal-and-kim-1-for-acute-kidney-injury-in-patients-with-scrub-typhus
#4
In O Sun, Sung Hye Shin, A Young Cho, Hyun Ju Yoon, Mi Yok Chang, Kwang Young Lee
BACKGROUND: The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. METHODS: From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI...
2017: PloS One
https://www.readbyqxmd.com/read/28416778/steroid-pulse-therapy-for-de-novo-minimal-change-disease-during-pregnancy
#5
Hiroshi Sato, Yuna Asami, Reona Shiro, Masato Aoki, Miki Yasuda, Saeko Imai, Rie Sakai, Kenji Oida, Kanako Kawaharamura, Hiroko Yano, Nao Taguchi, Takako Suzuki, Masaya Hirose
BACKGROUND Nephrotic syndrome occurs very rarely, in only about 0.01%-0.02% of all pregnancies, and de novo minimal change disease during pregnancy is especially rare. Nephrotic syndrome and, especially, minimal change disease are highly responsive to steroids, and preterm labor may be avoidable if the maternal condition is improved with steroid therapy. Therefore, prompt diagnosis and proper management are critical to maternal and fetal outcome when severe proteinuria occurs during pregnancy. CASE REPORT A 30-year-old pregnant Japanese woman presented with systemic edema, oliguria, and severe proteinuria and hypoalbuminemia at 25 weeks of gestation, although she was normotensive...
April 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28409239/macrophage-activation-syndrome-in-systemic-lupus-erythematosus-a-multicenter-case-control-study-in-china
#6
Ai-Chun Liu, Yue Yang, Meng-Tao Li, Yuan Jia, Sheng Chen, Shuang Ye, Xiang-Zong Zeng, Zhao Wang, Jin-Xia Zhao, Xiang-Yuan Liu, Jian Zhu, Yan Zhao, Xiao-Feng Zeng, Zhan-Guo Li
The objective of this study was to describe the clinical and laboratory characteristics, precipitating factors, treatment, and outcome of macrophage activation syndrome (MAS) complicating systemic lupus erythematosus (SLE). A multicenter case-control study was performed across six tertiary hospitals from 1997 to 2014. A total of 32 patients with SLE-associated MAS were enrolled. Sixty-four age- and sex-matched SLE patients diagnosed in the same period without MAS episodes were selected as controls. The most frequent clinical feature was fever, followed by splenomegaly...
April 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28409147/incidence-and-predictors-of-advanced-liver-fibrosis-by-a-validated-serum-biomarker-in-liver-transplant-recipients
#7
Mamatha Bhat, Kathleen C Rollet-Kurhajec, Aparna Bhat, Amanda Farag, Marc Deschenes, Philip Wong, Peter Ghali, Giada Sebastiani
Background and Aims. Serum fibrosis biomarkers have shown good accuracy in the liver transplant (LT) population. We employed a simple serum biomarker to elucidate incidence and predictors of advanced fibrosis after LT over a long follow-up period. Methods. We included 440 consecutive patients who underwent LT between 1991 and 2013. Advanced liver fibrosis was defined as FIB-4 > 3.25 beyond 12 months after LT. Results. Over 2030.5 person-years (PY) of follow-up, 189 (43%) developed FIB-4 > 3.25, accounting for an incidence of 9...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28408622/a-host-dependent-prognostic-model-for-elderly-patients-with-diffuse-large-b-cell-lymphoma
#8
Katsuhiro Miura, Jun Konishi, Takaaki Miyake, Masanori Makita, Atsuko Hojo, Yasufumi Masaki, Masatoshi Uno, Jun Ozaki, Chikamasa Yoshida, Daigo Niiya, Koichi Kitazume, Yoshinobu Maeda, Jun Takizawa, Rika Sakai, Tomofumi Yano, Kazuhiko Yamamoto, Kazutaka Sunami, Yasushi Hiramatsu, Kazutoshi Aoyama, Hideki Tsujimura, Jun Murakami, Yoshihiro Hatta, Masatoshi Kanno
BACKGROUND: Decision-making models for elderly patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) are in great demand. PATIENTS AND METHODS: The Society of Lymphoma Treatment in Japan (SoLT-J), in collaboration with the West-Japan Hematology and Oncology Group (West-JHOG), collected and retrospectively analyzed the clinical records of ≥65-year-old patients with DLBCL treated with R-CHOP from 19 sites across Japan to build an algorithm that can stratify adherence to R-CHOP...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28402974/cardiac-changes-and-their-association-with-fetuin-a-and-fibroblast-growth-factor-23-in-children-with-chronic-kidney-disease
#9
Abdullahi Mudi, Hopewell Ntsinjana, Caroline Dickens, Cecil Levy, Daynia Ballot
AIMS: In children with chronic kidney disease (CKD), fetuin-A and fibroblast growth factor-23 (FGF-23) have been implicated in the mechanism and progression of several cardiac changes. This study aimed to determine the types and rates of cardiac changes in children with CKD and their association with fetuin-A, FGF-23, and other cardiovascular risk factors (CVRFs). METHODS: This comparative cross-sectional study recruited 88 children (5-18 years): 27 CKD I with a glomerular filtration rate (GFR) >90 mL/min/1...
April 13, 2017: Nephron
https://www.readbyqxmd.com/read/28394902/correlation-of-hippocampal-atrophy-with-hyperhomocysteinemia-in-hemodialysis-patients-an-exploratory-pilot-study
#10
Kyoko Maesato, Takayasu Ohtake, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi
BACKGROUND: Cognitive impairment is one of the important critical issues in hemodialysis (HD) patients. However, the associating factors of brain atrophy in HD patients have not been fully elucidated. PURPOSE AND METHODS: Brain magnetic resonance imaging (MRI) was performed in 34 of total 72 HD outpatients in our dialysis center. These MRI images were analyzed by an application software; Voxel-based Specific Regional Analysis System for Alzheimer's Disease (VSRAD)...
2017: PloS One
https://www.readbyqxmd.com/read/28386144/self-healing-juvenile-cutaneous-mucinosis
#11
Beata Kołodziejczyk, Agnieszka Gazda, Elżbieta Hernik, Izabela Szczygielska, Lidia Rutkowska-Sak, Marta Legatowicz Koprowska
Girl, aged 4 years old, began the disease with pain of the lower extremities, fever up to 38°C and signs of upper airway infection. Then the patient developed oedema and redness of the whole face, thickened skin, subcutaneous nodular foldings of the frontal, occipital, cervical and axillary regions, extensor areas of the joints; fine, hard whitish nodules in the frontal region and over interphalangeal joints of the hands, pruritus; oedemas of the ankles, knees and joints of the hands, cervical lymphadenopathy and hepatomegaly...
2017: Reumatologia
https://www.readbyqxmd.com/read/28385149/successful-treatment-with-bortezomib-and-dexamethasone-for-proliferative-glomerulonephritis-with-monoclonal-igg-deposits-in-multiple-myeloma-a-case-report
#12
Rio Noto, Nozomu Kamiura, Yuichiro Ono, Sumie Tabata, Shigeo Hara, Hideki Yokoi, Akihiro Yoshimoto, Motoko Yanagita
BACKGROUND: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a form of renal involvement by monoclonal IgG deposits that was found in mesangial, subendothelial or subepithelial regions. The distribution of glomerular deposits was completely different from that in monoclonal immunoglobulin deposition disease. PGNMID is reported to be rarely associated with a hematological malignancy. Previously, only five cases of PGNMID with multiple myeloma have been reported...
April 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28382389/ct-guided-intranodal-lymphangiography-for-postoperative-chylous-ascites
#13
Masanori Hirata, Atsuo Shimizu, Shoko Abe, Azusa Ichinose, Akira Sugiyama, Yusuke Tanino, Suguru Watanabe, Ryota Nakano, Yoshihiko Kato, Toshiyuki Miyahara, Yasuhiro Sumi, Hiroshi Nakano
The utility and minimal invasiveness of ultrasound-guided intranodal lymphangiography have already been reported by several researchers. Although ultrasound-guided intranodal lymphangiography is known to be not technically difficult in general, a patient's edematous groin due to hypoalbuminemia resulting from chylous ascites made it too challenging to detect and prick the lymph nodes precisely. This report describes a 71-year-old female with refractory chylous ascites due to an operation for an extrahepatic bile duct cancer, who was successfully treated by computed tomography (CT)-guided intranodal lymphangiography...
April 5, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28376626/waldmann-s-disease-a-rare-cause-of-protein-losing-enteropathy-in-an-adult-patient
#14
Cláudio Rodrigues Martins, Alice Gagnaire, Florian Rostain, Come Lepage
Primary intestinal lymphangiectasia or Waldmann's disease is an uncommon cause of protein losing enteropathy with an unknown etiology and is usually diagnosed during childhood. It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. Differential diagnosis should include erosive and non-erosive gastrointestinal disorders, conditions involving mesenteric lymphatic obstruction and cardiovascular disorders that increase central venous pressure...
April 5, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28375198/lupus-protein-losing-enteropathy-patient-with-protein-c-and-protein-s-deficiency-induced-thrombosis-a-case-report-with-review-of-the-literature
#15
Ratchaya Lertnawapan, Dussadee Sakonlaya
A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with high dose steroid, azathioprine, mycophenolate mofetil and cyclophosphamide. Bowel resection was performed without improvement. Fortunately, the patient responded to another course of pulse methyl prednisolone and a second line medication after surgery...
March 27, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28363494/clinical-and-endoscopic-features-in-patients-with-hospital-acquired-diarrhea-associated-with-clostridium-difficile-infection
#16
J A Velarde Ruiz-Velasco, J M Aldana-Ledesma, M A Ibarra-Estrada, S A Aguirre Díaz, J A Fernández-Ramírez, F Cárdenas-Lara, F Álvarez López, L E Rodríguez-Noriega, H R Pérez-Gómez, M R Morfín-Otero
BACKGROUND AND AIMS: Clostridium difficile (CD) is the leading cause of hospital-acquired diarrhea. Clinical and endoscopic findings are poorly described in our country. The aim of this study is to depict those findings. MATERIAL AND METHODS: Prospective cohort study, which included patients with CD associated hospital-acquired diarrhea, diagnosed by means of fecal PCR and testing for the presence of hypervirulent strain NAP027. We analyzed clinical and endoscopic features, as well as the variables associated with severe disease...
March 28, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28363254/pancreatic-neuroendocrine-carcinoma-with-exocrine-differentiation-in-a-young-cat
#17
Masaki Michishita, Mariko Takagi, Takuya E Kishimoto, Rei Nakahira, Takeshi Nogami, Hisashi Yoshimura, Hitoshi Hatakeyama, Daigo Azakami, Kazuhiko Ochiai, Kimimasa Takahashi
A 35-mo-old spayed female mixed-breed cat with continuous vomiting, emaciation, and abdominal distention for 2 wk was presented to a private veterinary clinic for evaluation. At 71 d after the initial visit, the cat died with anemia, jaundice, and hypoalbuminemia, and was subjected to autopsy. Grossly, numerous firm masses, 0.5-2.5 cm diameter, were randomly located in the left lobe of the pancreas. Histologic examination revealed that the pancreatic mass consisted of 2 tumor cell types: mostly small round cells with a minority of epithelial cells...
March 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28359793/preoperative-hypoalbuminemia-is-a-risk-factor-for-early-and-late-mortality-in-patients-undergoing-endovascular-juxtarenal-and-thoracoabdominal-aortic-aneurysm-repair
#18
M Wohlauer, C Brier, Y Kuramochi, M Eagleton
INTRODUCTION: Advances in endovascular aneurysm repair now allow surgeons to treat high risk patients with complex aortic aneurysms. Stringent selection criteria for repair exists from an anatomic and technical perspective, however there is a paucity of literature examining frailty in patients being evaluated for fenestrated and branched endovascular aortic repair (FEVAR). As a marker of frailty well supported in the literature, we hypothesized that preoperative hypoalbuminemia would increase risk for short-term mortality following endovascular juxtarenal and thoracoabdominal aortic aneurysm repair...
March 27, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28358923/impact-of-systemic-inflammation-on-gastric-cancer-outcomes
#19
Xuechao Liu, Shangxiang Chen, Jianjun Liu, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Xiaowei Sun
BACKGROUND: The prognostic value of neutrophil-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) has been extensively validated in various cancers. We aimed to examine the usefulness of a combination of NLR and GPS (named CNG) for predicting survival outcomes in patients after curative resection for gastric cancer (GC). METHODS: We retrospectively analyzed the records of 1056 patients who underwent curative resection as initial treatment for GC from October 2000 to September 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28355401/schistosoma-mansoni-associated-glomerulopathy-with-iga-mesangial-deposits-case-report
#20
Fabiana Oliveira Gonçalves, Tânia Maria de Souza Fontes, Ana Paula Pereira Santana Lemes Canuto
INTRODUCTION: Renal involvement is a severe form of schistosomiasis and occurs in 10% to 15% of patients with the hepatosplenic form of the disease. Nephrotic syndrome is the most common clinical presentation. It is a complication caused by immune complexes (IC), it is rare to appear in the Brazilian context with a immunoglobulin A (IgA) deposits. When installed the renal injury by Schistosoma mansoni, classically presents as membranoproliferative glomerulonephritis (mesangiocapillary) with lobular accentuation...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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