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Hypoalbuminemia

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https://www.readbyqxmd.com/read/29430446/models-of-disuse-muscle-atrophy-therapeutic-implications-in-critically-ill-patients
#1
REVIEW
Esther Barreiro
Skeletal muscle weakness is common in the intensive care units (ICU). Approximately 50% of patients under mechanical ventilation for more than 7 days show signs of ICU-acquired muscle weakness. In these patients, muscle weakness may be the result of axonal polyneuropathy, myopathy or a combination of both. The commonest risk factors in patients with ICU-acquired weakness (AW) are the severity and duration of the systemic inflammatory response, duration of the stay in the ICU and of mechanical ventilation, hyperglycemia, hypoalbuminemia, parenteral nutrition, and administration of corticosteroids and of neuromuscular blocking agents...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29428866/prognostic-value-of-circulating-biomarker-score-in-advanced-stage-head-and-neck-squamous-cell-carcinoma
#2
Marn Joon Park, Jong-Lyel Roh, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Circulating biomarker (CB) is a convenient, emerging predictive tool for treatment response and outcomes in human cancers. Therefore, we examined the prognostic value of pre-treatment and early post-treatment CBs and their summated scores in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This study prospectively included 310 consecutive patients who underwent definitive treatment for previously untreated advanced-stage HNSCC between 2010 and 2015...
February 8, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29424482/zinc-deficiency-like-syndrome-in-fleckvieh-calves-clinical-and-pathological-findings-and-differentiation-from-bovine-hereditary-zinc-deficiency
#3
M C Langenmayer, S Jung, M Majzoub-Altweck, F M Trefz, C Seifert, G Knubben-Schweizer, R Fries, W Hermanns, N S Gollnick
BACKGROUND: Zinc deficiency-like (ZDL) syndrome is an inherited defect of Fleckvieh calves, with striking similarity to bovine hereditary zinc deficiency (BHZD). However, the causative mutation in a phospholipase D4 encoding gene (PLD4) shows no connection to zinc metabolism. OBJECTIVES: To describe clinical signs, laboratory variables, and pathological findings of ZDL syndrome and their utility to differentiate ZDL from BHZD and infectious diseases with similar phenotype...
February 9, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29421796/variability-in-predialysis-systolic-blood-pressure-and-long-term-outcomes-in-hemodialysis-patients
#4
Ying Wang, Yan Qin, Xiaohong Fan, Jianfang Cai, Wei Ye, Jinghua Xia, Mingxi Li, Xuemei Li, Xuewang Li, Limeng Chen
BACKGROUND/AIMS: While systolic blood pressure variability (SBPV) is an independent risk factor for mortality in the general population, its association with outcomes in hemodialysis patients has been less well-investigated. METHODS: In this retrospective study, we enrolled 99 eligible HD patients from 2006 to 2016. Predialysis blood pressure measurements obtained over 1-year period were used to determine each patient's BPV. The standard deviation (SD), the coefficient of variation (CV) and the variation independent of the mean (VIM) were used as metrics of BPV...
January 31, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29409111/pre-operative-core-muscle-index-in-combination-with-hypoalbuminemia-is-associated-with-poor-prognosis-in-advanced-ovarian-cancer
#5
Lesley B Conrad, Haitham Awdeh, Stefany Acosta-Torres, Steven A Conrad, April A Bailey, David S Miller, Jayanthi S Lea
BACKGROUND AND OBJECTIVES: Age and frailty have been correlated with poor clinical outcomes in cancer. Core muscle index (CMI) and nutritional status are integral in assessing frailty. We explored the effect of pre-operative serum albumin and body composition on clinical outcomes in patients with epithelial ovarian cancer (EOC). METHODS: We identified stage III-IV EOC patients undergoing primary cytoreductive surgery from 2007 to 2015. Data were abstracted from medical records...
February 6, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29408835/incidence-and-factors-correlating-with-incisional-hernia-following-open-bowel-resection-in-patients-with-inflammatory-bowel-disease-a-review-of-1000-patients
#6
Tomas M Heimann, Santosh Swaminathan, Adrian J Greenstein, Randolph M Steinhagen
OBJECTIVE: The aim of this study was to identify the incidence and factors associated with the development of incisional hernia (IH) in patients with inflammatory bowel disease (IBD) undergoing open bowel resections. BACKGROUND: Predisposing factors for IH have not been well studied in patients with IBD undergoing open bowel resection. The role of duration of the disease, nutritional factors, anti-inflammatory treatment, previous operative procedures, wound infection, and other complicating factors remains unclear...
March 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29406463/malnutrition-growth-response-and-metabolic-changes-within-the-first-24-months-after-art-initiation-in-hiv-infected-children-treated-before-the-age-of-two-years-in-west-africa
#7
Julie Jesson, Désiré L Dahourou, Madeleine Amorissani Folquet, Karen Malateste, Caroline Yonaba, Marie-Sylvie N'Gbeche, Sylvie Ouédraogo, Véronique Mea-Assande, Clarisse Amani-Bossé, Stéphane Blanche, Marguerite Timité-Konan, Valériane Leroy
BACKGROUND: There is limited information about malnutrition, growth evolution and metabolic changes among children initiated early on lopinavir-based antiretroviral therapy (ART) in Africa. METHODS: HIV-1-infected children, age <2 years were initiated on ART, as part of the MONOD ANRS 12206 project, conducted in Burkina Faso and Côte d'Ivoire. Weight-for-age, height-for-age and weight-for-height Z-scores (WAZ, HAZ, WHZ) defined malnutrition (Z-score <-2 standard deviations [SD]) using WHO growth references...
February 3, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29402775/intradialytic-hypotension-as-an-independent-risk-factor-for-long-term-mortality-in-maintaining-hemodialysis-patients-a-5-year-follow-up-cohort-study
#8
Jinbo Yu, Zhonghua Liu, Bo Shen, Jie Teng, Jianzhou Zou, Xiaoqiang Ding
AIMS: This study aimed to assess risk factors of intradialytic hypotension (IDH) and the association of prognosis and IDH among maintenance hemodialysis (MHD) patients. METHODS: Among 293 patients, 117 were identified with IDH (more than 4 hypotensive events during 3 months). The association between IDH and survival was evaluated. RESULTS: The incidence of IDH was 39.9%. Age, ultrafiltration rate, N-terminal pro-B-type natriuretic peptide (NT-proBNP), albumin, β2-microglobulin (β2MG), and aortic root inside diameter (AoRD) were independently associated with IDH...
February 2, 2018: Blood Purification
https://www.readbyqxmd.com/read/29391160/identification-of-independent-risk-factors-for-complications-a-retrospective-analysis-of-163-fibular-free-flaps-for-mandibulofacial-reconstruction
#9
Haixuan Wu, Funing Liu, Fengtao Ji, Mingyan Guo, Youyuan Wang, Minghui Cao
PURPOSE: Fibular free flap transfer is a powerful tool available to the reconstructive surgeon when treating oral and maxillofacial defects, but complications still occasionally occur and predictive analysis focusing on this specific flap is limited in terms of risk factors for complication. The purpose of this study was to identify key variables associated with complications in patients undergoing fibular free flap transfer. PATIENTS AND METHODS: The data of 163 consecutive patients who underwent fibular free flap surgery at the Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, between 2012 and 2015 were reviewed retrospectively...
January 8, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29387396/impact-of-body-mass-index-on-clinicopathological-outcomes-in-patients-with-renal-cell-carcinoma-without-anorexia-cachexia-syndrome
#10
Daisuke Watanabe, Akio Horiguchi, Shinsuke Tasaki, Kenji Kuroda, Akinori Sato, Junichi Asakuma, Keiichi Ito, Tomohiko Asano
Although obesity defined by a high body mass index (BMI) is generally associated with increased risk of renal cell carcinoma (RCC), low BMI has paradoxically been associated with increased tumor aggressiveness and poor prognosis. As anorexia-cachexia syndrome (ACS) is associated with decreased BMI and is frequently observed in patients with advanced RCC, the present study investigated the association of BMI with tumor aggressiveness and prognosis in RCC in relation to ACS. The association of BMI with clinicopathological parameters was analyzed in 503 consecutive patients who underwent surgery for RCC...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29382316/a-model-for-predicting-bacteremia-in-patients-with-community-acquired-pneumococcal-pneumonia-a-retrospective-observational-study
#11
Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida, Akio Yamazaki
BACKGROUND: Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development of bacteremia in patients with community-acquired pneumococcal pneumonia. METHODS: We retrospectively analyzed data from patients hospitalized with community-acquired pneumococcal pneumonia between April 2007 and August 2015. Logistic regression models were applied to detect risk factors for pneumococcal bacteremia, and a receiver operating characteristic curve was used to devise a prediction model...
January 30, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29368107/predictors-of-severity-in-pediatric-scrub-typhus
#12
Dinesh Kumar Narayanasamy, Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Devi Kittu, Shanthi Ananthakrishnan
OBJECTIVE: To identify the factors that can predict the severity of scrub typhus in children. METHODS: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. These children were followed during the hospital course and their laboratory results, response to treatment and complications were documented...
January 24, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29368078/kasai-procedure-improves-nutritional-status-and-decreases-transplantation-associated-complications
#13
Jixin Yang, Wei Gao, Jianghua Zhan, Jiexiong Feng
BACKGROUND: The aim of this study was to retrospectively investigate whether Kasai Procedure (KP) improves nutritional status and whether KP decreases liver transplantation (LT)-associated complications in children with biliary atresia (BA). METHODS: From March 1st 2014 to February 28th 2015, 103 patients underwent LT and the other 17 without prior KP died during the waiting period. In 103 patients undergoing LT, 58 patients received KP previously (Group A), and 45 only underwent primary LT (Group B)...
January 24, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29356829/clinical-biomarker-and-molecular-delineations-and-genotype-phenotype-correlations-of-ataxia-with-oculomotor-apraxia-type-1
#14
Mathilde Renaud, Maria-Céu Moreira, Bondo Ben Monga, Diana Rodriguez, Rabab Debs, Perrine Charles, Malika Chaouch, Farida Ferrat, Chloé Laurencin, Laurent Vercueil, Martial Mallaret, Abderrahim M'Zahem, Lamia Ali Pacha, Meriem Tazir, Caroline Tilikete, Elisabeth Ollagnon, François Ochsner, Thierry Kuntzer, Hans H Jung, Jean-Marie Beis, Jean-Claude Netter, Atbin Djamshidian, Mattew Bower, Armand Bottani, Richard Walsh, Sinead Murphy, Thomas Reiley, Éric Bieth, Filip Roelens, Bwee Tien Poll-The, Charles Marques Lourenço, Laura Bannach Jardim, Rachel Straussberg, Pierre Landrieu, Emmanuel Roze, Stéphane Thobois, Jean Pouget, Claire Guissart, Cyril Goizet, Alexandra Dürr, Christine Tranchant, Michel Koenig, Mathieu Anheim
Importance: Ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive cerebellar ataxia due to mutations in the aprataxin gene (APTX) that is characterized by early-onset cerebellar ataxia, oculomotor apraxia, axonal motor neuropathy, and eventual decrease of albumin serum levels. Objectives: To improve the clinical, biomarker, and molecular delineation of AOA1 and provide genotype-phenotype correlations. Design, Setting, and Participants: This retrospective analysis included the clinical, biological (especially regarding biomarkers of the disease), electrophysiologic, imaging, and molecular data of all patients consecutively diagnosed with AOA1 in a single genetics laboratory from January 1, 2002, through December 31, 2014...
January 22, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29356783/hypoalbuminemia-is-associated-with-significantly-higher-liver-transplant-waitlist-mortality-and-lower-probability-of-receiving-liver-transplant
#15
Joseph Ahn, Vinay Sundaram, Walid S Ayoub, Catherine Frenette, Robert J Wong
GOALS: To evaluate the predictive value of hypoalbuminemia on liver transplant (LT) waitlist survival and probability of receiving LT among adults with end-stage liver disease (ESLD). BACKGROUND: Growing evidence reports on the negative prognostic value of hypoalbuminemia among ESLD patients awaiting LT. METHODS: Using 2003 to 2015 United Network for Organ Sharing data, we retrospectively evaluated the impact of mild-moderate (2.5 to 3.4 g/dL) and severe hypoalbuminemia (<2...
January 19, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29350604/letter-to-the-editor-is-preoperative-hypoalbuminemia-really-a-risk-factor-associated-with-acute-kidney-injury-and-mortality-after-brain-tumor-surgery
#16
Fu-Shan Xue, Gui-Zhen Yang, Hui-Xian Li, Ya-Yang Liu
No abstract text is available yet for this article.
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29349731/membranous-nephropathy-associated-with-pregnancy-an-anti-phospholipase-a2-receptor-antibody-positive-case-report
#17
Eiichiro Uchino, Daisuke Takada, Haruta Mogami, Takeshi Matsubara, Tatsuo Tsukamoto, Motoko Yanagita
Pregnancy and membranous nephropathy (MN) can occur concurrently with nephrotic syndrome. However, the pathophysiology of MN associated with pregnancy remains unclear, including the involvement of anti-M-type phospholipase A2 receptor (PLA2R) antibody, the major antigen of idiopathic MN (iMN). A treatment for the condition is also not established. We present the case of a 43-year-old pregnant female with incidental proteinuria and hypoalbuminemia. We made a diagnosis of nephrotic syndrome at 11 week gestation...
January 18, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29348382/the-effect-of-ophiocephalus-striatus-extract-on-the-levels-of-igf-1-and-albumin-in-elderly-patients-with-hypoalbuminemia
#18
Roza Mulyana, Siti Setiati, Rose D Martini, Kuntjoro Harimurti, Noto Dwimartutie
BACKGROUND: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia. METHODS: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29344912/capillary-leak-syndrome-as-a-complication-of-antibody-mediated-rejection-treatment-a-case-report
#19
Juan C Ramirez-Sandoval, Ricardo Varela-Jimenez, Luis E Morales-Buenrostro
We report a case of capillary leak that developed during treatment of antibody-mediated rejection in a kidney transplant recipient. A 53-year-old female transplant recipient experienced an increase in serum creatinine from 1.1 to 1.8 mg/dL. Antibody-mediated rejection was diagnosed by graft biopsy. She was treated with five plasmapheresis sessions (on alternate days with albumin replacement), five doses of immunoglobulin (5 g/dose at 100 mg/kg), a single dose of rituximab (500 mg), and four doses of bortezomib on days 1, 4, 7, and 10 (1...
January 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#20
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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