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Hypoalbuminemia

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https://www.readbyqxmd.com/read/29244111/serum-albumin-as-a-prognostic-marker-for-serious-non-aids-endpoints-in-the-strategic-timing-of-antiretroviral-treatment-start-study
#1
Andreas Ronit, Shweta Sharma, Jason V Baker, Rosie Mngqibisa, Tristan Delory, Luis Caldeira, Nicaise Ndembi, Jens D Lundgren, Andrew N Phillips
Background: Serum albumin may be used to stratify human immunodeficiency virus (HIV)-infected persons with high CD4 count according to their risk of serious non-AIDS endpoints. Methods: Cox proportional hazards models were used to analyze the risk of serious non-AIDS events in the Strategic Timing of Antiretroviral Treatment (START) study (NCT00867048) with serum albumin as a fixed and time-updated predictor. Models with exclusion of events during initial follow-up years were built to assess the ability of serum albumin to predict beyond shorter periods of time...
December 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29241141/plasma-exchange-in-severe-acute-relapses-of-multiple-sclerosis-results-from-a-portuguese-cohort
#2
Inês Correia, Joana Jesus Ribeiro, Luís Isidoro, Sónia Batista, Carla Nunes, Carmo Macário, Catarina Borges, Jorge Tomaz, Lívia Sousa
BACKGROUND: Relapses in Multiple Sclerosis (MS) are often associated with significant disability impairment which is resultant from poor response to corticosteroids. In such severe cases, plasma exchange (PLEX) may be used, although only a few studies with MS patients have been reported. Our objective was to evaluate the effectiveness of PLEX in severe relapses of MS. METHODS: Retrospective study of MS patients treated with PLEX in acute relapses. Data regarding EDSS, annualized relapse rate (ARR), treatment with corticosteroids, number of PLEX sessions, adverse events, and gadolinium enhancement in brain MRI were analysed...
December 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29230300/preoperative-hypoalbuminemia-is-associated-with-an-increased-risk-for-intra-abdominal-septic-complications-after-primary-anastomosis-for-crohn-s-disease
#3
Xuanhui Liu, Xianrui Wu, Chi Zhou, Tuo Hu, Jia Ke, Yufeng Chen, Xiaosheng He, Xiaobin Zheng, Xiaowen He, Jiancong Hu, Min Zhi, Xiang Gao, Pinjin Hu, Xiaojian Wu, Ping Lan
Objective: The aim of this study was to evaluate the impact of preoperative hypoalbuminemia on the development of intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn's disease (CD). Methods: All CD patients undergoing bowel resection with a primary anastomosis during the study period from 2007 to 2015 were enrolled. The association of preoperative hypoalbuminemia (<30 g/L) with the risk for IASCs were assessed using both univariate and multivariate analyses...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29227327/effect-of-nutritional-risk-on-short-term-outcomes-after-laparoscopic-assisted-gastrectomy-a-prospective-study-from-two-centers
#4
Wei-Zhe Chen, Xi-Yi Chen, Feng-Min Zhang, Qian-Tong Dong, Yan-Bin Ji, Xiao-Lei Chen, Cheng-Le Zhuang, Xiao-Xi Chen
BACKGROUND/AIM: The aim of this prospective double-center study was to explore the effect of nutritional risk on short-term outcomes in the patients who had gastric cancer and underwent a laparoscopic-assisted gastrectomy. PATIENTS AND METHODS: We conducted a study of patients who underwent laparoscopic-assisted gastrectomy in two large centers between June 2014 and April 2017. Patients' demographic and clinical characteristics and postoperative short-term outcomes were prospectively analyzed...
December 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29227024/blood-biomarkers-as-predictors-of-long-term-mortality-in-copd
#5
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Janvier Gasana
BACKGROUND: Blood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity. AIM: To determine whether a panel of blood biomarkers (C-reactive protein [CRP], neutrophils, eosinophils, albumin and vitamin D) could predict mortality in COPD. METHODS: we analyzed data from 431 COPD participants to the 2007-2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months...
December 11, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29219627/non-oncotic-properties-of-albumin-a-multidisciplinary-vision-about-the-implications-for-critically-ill-patients
#6
Ricard Ferrer, Xavier Mateu, Emilio Maseda, Juan Carlos Yébenes, César Aldecoa, Candelaria De Haro, Juan Carlos Ruiz-Rodriguez, José Garnacho-Montero
Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects. Areas covered: The potential clinical benefits of albumin in select populations of critically ill patients like sepsis seem related to immunomodulatory and anti-inflammatory effects, antibiotic transportation and endothelial stabilization. Albumin transports many drugs used in critically ill patients...
December 8, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29218062/preliminary-study-regarding-the-association-between-tumor-necrosis-factor-alpha-gene-polymorphisms-and-childhood-idiopathic-nephrotic-syndrome-in-romanian-pediatric-patients
#7
Ioana Tieranu, Monica I Dutescu, Constantin Bara, Cristian G Tieranu, Mihaela Balgradean, Olivia M Popa
Background: Childhood idiopathic nephrotic syndrome (INS) is one of the most common glomerular diseases, characterized by heavy proteinuria, hypoalbuminemia, dyslipidemia and generalized edema. Although some progresses were made regarding the pathogenesis of this disease, there are a lot of questions still left unanswered. Some of them involve the implications of several cytokines, including tumor necrosis factor alpha (TNF-alpha), in the development and clinical course of INS. Objective: Our objective was to analyze the role of two single nucleotide polymorphisms of TNF-alpha gene in the development of pediatric INS and their implication in the response to corticosteroid therapy...
September 2017: Mædica
https://www.readbyqxmd.com/read/29214518/outcome-of-older-persons-admitted-to-intensive-care-unit-mortality-prognosis-factors-dependency-scores-and-ability-trajectory-within-1%C3%A2-year-a-prospective-cohort-study
#8
Claude Level, Eric Tellier, Patrick Dezou, Karim Chaoui, Aissa Kherchache, Philippe Sejourné, Anne Marie Rullion-Pac Soo
BACKGROUND: The outcome and functional trajectory of older persons admitted to intensive care (ICU) unit remain a true question for critical care physicians and geriatricians, due to the heterogeneity of geriatric population, heterogeneity of practices and absence of guidelines. AIM: To describe the 1-year outcome, prognosis factors and functional trajectory for older people admitted to ICU. METHODS: In a prospective 1-year cohort study, all patients aged 75 years and over admitted to our ICU were included according to a global comprehensive geriatric assessment...
December 6, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29206328/nutritional-and-hematologic-markers-as-predictors-of-risk-of-surgical-site-infection-in-patients-with-head-and-neck-cancer-undergoing-major-oncologic-surgery
#9
Ho-Jin Son, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Surgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. METHODS: The study involved 369 patients who underwent surgery for head and neck cancer. Hematological and nutritional parameters were measured preoperatively and postoperatively. Univariate and multivariate analyses were used to determine the risk factors for surgical site infection...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29204346/drug-induced-hypersensitivity-syndrome-caused-by-valproic-acid-as-a-monotherapy-for-epilepsy-first-case-report-in-asian-population
#10
X T Wu, P W Hong, D J Suolang, D Zhou, H Stefan
Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29199253/-effects-of-pharmacist-intervention-on-the-treatment-of-infectious-diseases-in-critically-ill-patients
#11
Masaharu Imaura
 The pathological conditions of patients who require intensive care are usually complex and extremely severe; their health and life are in a critical state. Therefore, correct, rapid treatment of these conditions is indispensable. Furthermore, the selection of drugs and adjustment of their dosage for an immediate effect are important. Moreover, most patients are immunocompromised and present an extremely high level of risk for complications involving infectious diseases. Since such complications may lead to life-threatening outcomes, a rational dosage regimen to achieve sufficient antimicrobial activity from the initial stage of treatment is essential...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29192637/predictors-of-vitamin-d-deficiency-in-predialysis-patients-with-stage-3-5-chronic-kidney-diseases-in-southern-china
#12
M Feng, J Lv, F T Huang, P F Liang, S Fu, Y C Zeng, Y Tang, A P Xu
OBJECTIVE: Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKDs in Southern China. METHODS: In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29190884/the-autophagy-marker-lc3-strongly-predicts-immediate-mortality-after-surgical-resection-for-hepatocellular-carcinoma
#13
Chih-Wen Lin, Chih-Che Lin, Po-Huang Lee, Gin-Ho Lo, Pei-Min Hsieh, Kah Wee Koh, Chih-Yuan Lee, Yao-Li Chen, Chia-Yen Dai, Jee-Fu Huang, Wang-Long Chuang, Yaw-Sen Chen, Ming-Lung Yu
The remnant liver's ability to regenerate may affect post-hepatectomy immediate mortality. The promotion of autophagy post-hepatectomy could enhance liver regeneration and reduce mortality. This study aimed to identify predictive factors of immediate mortality after surgical resection for hepatocellular carcinoma (HCC). A total of 535 consecutive HCC patients who had undergone their first surgical resection in Taiwan were enrolled between 2010 and 2014. Clinicopathological data and immediate mortality, defined as all cause-mortality within three months after surgery, were analyzed...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29184425/obesity-and-morbid-obesity-associated-with-higher-odds-of-hypoalbuminemia-in-adults-without-liver-disease-or-renal-failure
#14
Rana H Mosli, Hala H Mosli
Background and objective: Studies are needed in order to inform recommendations for interpreting albumin levels among obese individuals without known medical conditions associated with hypoalbuminemia. The objective of this study was to examine the association of obese and morbidly obese status with hypoalbuminemia, while adjusting for age, sex, diabetes, prediabetes, diabetic nephropathy, and nephrotic syndrome. Patients and methods: Retrospective data collection from adult patients presenting to the outpatient Endocrinology and Metabolism Clinic was performed between January 2015 and December 2015...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29183523/hypoalbuminemia-and-clinical-outcomes-what-is-the-mechanism-behind-the-relationship
#15
REVIEW
Sunghye Kim, Stephen A McClave, Robert G Martindale, Keith R Miller, Ryan T Hurt
Albumin has a number of important physiologic functions, which include maintaining oncotic pressure, transporting various agents (fatty acids, bile acids, cholesterol, metal ions, and drugs), scavenging free oxygen radicals, acting as an antioxidant, and exerting an antiplatelet effect. Hypoalbuminemia in adults, defined by an intravascular albumin level of <3.5 g/dL, is associated with poor postoperative outcomes in patients undergoing surgical intervention. Although the relationship of hypoalbuminemia and poor surgical outcome has been known for many years, the pathophysiology behind the relationship is unclear...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29183294/serum-albumin-level-as-a-potential-marker-for-deciding-chemotherapy-or-best-supportive-care-in-elderly-advanced-non-small-cell-lung-cancer-patients-with-poor-performance-status
#16
Satoshi Ikeda, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Takashi Niwa, Akihiro Nishiyama, Toshihide Yokoyama, Akimasa Sekine, Takashi Ogura, Tadashi Ishida
BACKGROUND: There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of chemotherapy for such patients remains unclear. The objective of this study was to identify factors that predicted the survival benefit of chemotherapy. METHODS: All consecutive elderly patients (≥75 years) with advanced NSCLC, Eastern Cooperative Oncology Group PS ≥2, EGFR mutation wild type/unknown, and newly diagnosed from January 2009 to December 2012 at a tertiary hospital were retrospectively reviewed...
November 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29170886/phase-ii-study-of-doxorubicin-and-thalidomide-in-patients-with-refractory-aggressive-fibromatosis
#17
Xin Liu, Huijie Wang, Xianghua Wu, Xiaonan Hong, Zhiguo Luo
Background To evaluate the efficacy and safety of doxorubicin (ADM) combined with thalidomide (THA) as a first-line treatment for patients with refractory aggressive fibromatosis (AF). Patients and Methods Eligible patients were treated with ADM 30 mg/m(2) on days 1-2 and THA 200 mg nightly on days 1-21 every 3 weeks for a maximum of six cycles. THA was then continued for a total of 1 year. The primary end point was response rate (RR). Results Fifteen patients were enrolled in the study. No patient had a complete response, but five patients had partial responses, resulting in a RR of 33%...
November 23, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29169714/-idiopathic-nephrotic-syndrome
#18
O Boyer, V Baudouin, E Bérard, C Dossier, V Audard, V Guigonis, I Vrillon
Nephrotic syndrome (NS) is defined by massive proteinuria and hypoalbuminemia, with resulting hyperlipidemia and edema. The most common cause of NS in children is idiopathic nephrotic syndrome (INS), also called nephrosis. Its annual incidence has been estimated to 1-4 per 100,000 children and varies with age, race, and geography. Many agents or conditions have been reported to be associated with INS such as infectious diseases, drugs, allergy, vaccinations, and malignancies. The disease may occur during the 1st year of life, but it usually starts between the ages of 2 and 7 years...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29161700/association-between-environmental-particulate-matter-and-carpal-tunnel-syndrome-in-patients-undergoing-hemodialysis
#19
Cheng-Hao Weng, Ching-Chih Hu, Tzung-Hai Yen, Wen-Hung Huang
BACKGROUND/AIMS: The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM2.5), have significantly been associated with the elevation of systemic inflammatory markers. There is no previous research on possible associations between CTS and PM2...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29156858/risk-factors-for-colistin-associated-nephrotoxicity-and-mortality-in-critically-ill-patients
#20
Hüseyin Özkarakaş, Işıl Köse, Çiler Zincircioğlu, Sibel Ersan, Gürsel Ersan, Nimet Şenoğlu, Şükran Köse, Rıza Hakan Erbay
Background/aim: Colistin is gaining popularity against multidrug-resistant bacteria. The primary concern with colistin is its nephrotoxicity (NT). The aim of this study was to evaluate the incidence and risk factors for NT and to evaluate the risk factors for mortality in the toxicity group. Materials and methods: NT was defined according to the RIFLE criteria. Data of patients who did or did not develop NT were compared. Positive and negative predictive values, risk ratio, and correlation coefficients were calculated...
August 23, 2017: Turkish Journal of Medical Sciences
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