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Folic acids

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https://www.readbyqxmd.com/read/28087280/increased-homocysteine-levels-impair-reference-memory-and-reduce-cortical-levels-of-acetylcholine-in-a-mouse-model-of-vascular-cognitive-impairment
#1
Kevin Dam, Martina Füchtemeier, Tracy D Farr, Philipp Boehm-Sturm, Marco Foddis, Ulrich Dirnagl, Olga Malysheva, Marie A Caudill, Nafisa M Jadavji
Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic (methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levels of homocysteine. Clinical studies have shown that elevated levels of homocysteine (Hcy) may be associated with the development of dementia, however this link remains unclear. The purpose of this study was to evaluate the impact of increased Hcy levels on a mouse model of vascular cognitive impairment (VCI) produced by chronic hypoperfusion...
January 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28081459/targeted-delivery-of-in-situ-pcr-amplified-sleeping-beauty-transposon-genes-to-cancer-cells-with-lipid-based-nanoparticle-like-protocells
#2
Kun Ma, Duo Fu, Dongli Yu, Changhao Cui, Li Wang, Zhaoming Guo, Chuanbin Mao
A Sleeping Beauty (SB) transposon system is made of a transposon plasmid (containing gene encoding a desired functional or therapeutic protein) and a transposase plasmid (encoding an enzyme capable of cutting and pasting the gene into the host cell genome). It is a kind of natural, nonviral gene delivery vehicle, which can achieve efficient genomic insertion, providing long-term transgenic expression. However, before the SB transposon system could play a role in promoting gene expression, it has to be delivered efficiently first across cell membrane and then into cell nuclei...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#3
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28079361/controllable-synthesis-of-smart-multifunctional-nanoscal-metal-organic-framework-for-magnetic-resonance-optical-imaging-and-targeted-drug-delivery
#4
Xuechuan Gao, Manjue Zhai, Weihua Guan, Jingjuan Liu, Zhiliang Liu, Alatangaole Damirin
As a result of their extraordinarily large surfaces and well-defined pores, the design of multifunctional metal-organic framework (MOF) is crucial for drug delivery while has been rarely reported. In this paper, a novel drug delivery system (DDS) based on nanoscale metal-organic framework (MOF) was developed for using in cancer diagnosis and therapy. This MOF based tumour targeting DDS was fabricated by a simple post-synthetic surface modification process. Firstly, magnetic mesoporous nanomaterial Fe-MIL-53-NH2 was devoted for encapsulating the drug and served as a magnetic resonance (MR) contrast agent...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078672/determinants-for-drug-survival-of-methotrexate-in-patients-with-psoriasis-split-for-different-reasons-of-discontinuation-results-of-the-prospective-mtx-capture
#5
M Otero, J van den Reek, M Seyger, P Van Der Kerkhof, W Kievit, E de Jong
BACKGROUND: Methotrexate is a widely used treatment for psoriasis. It is important to gain insight into the reasons for discontinuation of methotrexate and determinants for drug survival. OBJECTIVES: To describe 5-year drug survival for methotrexate in patients with psoriasis split for different reasons of discontinuation, and to identify determinants for drug survival. METHODS: Data were extracted from a prospective psoriasis registry of patients treated with methotrexate (MTX-CAPTURE)...
January 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28078529/rethinking-preconception-care-a-critical-women-s-health-perspective
#6
Erika L Thompson, Coralia Vázquez-Otero, Cheryl A Vamos, Stephanie L Marhefka, Nolan S Kline, Ellen M Daley
Objectives Preconception care aims to provide care to reproductive aged individuals in order to improve pregnancy and birth outcomes. Given that preconception care is a public health priority, it is important to evaluate the evolution of this health paradigm and the promotion of preconception messages that are obtained by the public. We identified online preconception health messages, which were critically assessed through a women's health perspective. Methods We searched for "preconception care" on three major search engines...
January 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28074742/development-and-validation-of-an-rp-hplc-method-for-the-determination-of-vinpocetine-and-folic-acid-in-the-presence-of-a-vinpocetine-alkaline-degradation-product-in-bulk-and-in-capsule-form
#7
Ehab F Elkady, Marwa H Tammam, Ayman A Mohamed
An alkaline-forced degradation hydrolytic product of vinpocetine was prepared and characterized by <sup>1</sup>H-NMR, FTIR spectroscopy, and MS. Subsequently, a simple, selective, and validated reversed-phase HPLC method was developed for the simultaneous estimation of vinpocetine and folic acid in the presence of a vinpocetine alkaline degradation product. Chromatographic separation was achieved using an isocratic mobile phase consisting of acetonitrile-0.02 M KH<sub>2</sub>PO<sub>4</sub> [containing 0...
January 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28073813/association-between-the-healthy-eating-index-2010-and-nutrient-and-energy-densities-of-german-households-food-purchases
#8
Jonas Peltner, Silke Thiele
BACKGROUND: The USDA Healthy Eating Index (HEI) is used widely to measure diet quality because it allows a number of different applications. Although several evaluations of the HEI-2010 have already been carried out, there is lack of those which focus on associations between the HEI and nutrient intakes. This study updates and expands upon previous findings on these associations. METHODS: Using German consumption data, where ∼12 million purchases from 13 131 households are recorded, HEI-2010 total and individual scores, as well as several energy and nutrient densities were calculated...
January 9, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28073680/rationale-and-design-of-pemvitastart-an-open-label-randomized-trial-comparing-simultaneous-versus-standard-initiation-of-vitamin-b12-and-folate-supplementation-in-nonsquamous-non-small-cell-lung-cancer-patients-undergoing-first-line-pemetrexed-based-chemotherapy
#9
Milind Baldi, Digambar Behera, Jyotdeep Kaur, Rakesh Kapoor, Navneet Singh
Pemetrexed is the preferred chemotherapeutic drug for nonsquamous, non-small-cell lung cancer patients whenever the predictive molecular biomarkers for targeted therapy have either not been assessed or are absent. As per manufacturers' instructions, supplementation with folic acid (FA; folate) at a dose of 350 to 1000 μg daily should be started seven days before the first dose of pemetrexed-based chemotherapy and continued during therapy and for 21 days after therapy cessation. Vitamin B12 injections (1000 μg intramuscularly) should also be started one week before the first dose of chemotherapy...
December 2, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28071985/the-contribution-of-prenatal-maternal-factors-to-maternal-gestational-weight-gain
#10
Sorayya Kheirouri, Mohammad Alizadeh
Data from 807 mothers in Iran delivering a singleton live infant and their offspring during the last two years up to August 2014 were collected from eight public health care centers and analyzed. Of women, 46.2% gained weight within the recommended range, 29.4% had inadequate and 24.4% had excessive gestational weight gain (GWG). Excessive GWG was more common among overweight and obese women, whereas inadequate GWG were prevalent among 50% of under and normal weight women. After adjusting for appropriate confounding factors the significant correlation was found between maternal anthropometric characteristics, folic acid intake during pregnancy and birth order with GWG...
January 10, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28069796/high-dietary-folate-in-pregnant-mice-leads-to-pseudo-mthfr-deficiency-and-altered-methyl-metabolism-with-embryonic-growth-delay-and-short-term-memory-impairment-in-offspring
#11
Renata H Bahous, Nafisa M Jadavji, Liyuan Deng, Marta Cosín-Tomás, Jessica Lu, Olga Malysheva, Kit-Yi Leung, Ming-Kai Ho, Mercè Pallàs, Perla Kaliman, Nicholas DE Greene, Barry J Bedell, Marie A Caudill, Rima Rozen
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C>T polymorphism) increases risk for complex traits, including neuropsychiatric disorders. Although low dietary folate impacts brain development, recent concerns have focused on high folate intake following food fortification and increased vitamin use. Our goal was to determine whether high dietary folate during pregnancy affects brain development in murine offspring...
January 9, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28067585/folic-acid-education-for-hispanic-women-the-promotora-de-salud-model
#12
Alina L Flores, Jennifer Isenburg, Christina L Hillard, Leslie deRosset, Lisa Colen, Troy Bush, Cara T Mai
BACKGROUND: Although rates of neural tube defects (NTDs) have declined in the United States since fortification, disparities still exist with Hispanic women having the highest risk of giving birth to a baby with a NTD. The Promotora de Salud model using community lay health workers has been shown to be an effective tool for reaching Hispanics for a variety of health topics; however, literature on its effectiveness in folic acid interventions is limited. MATERIALS AND METHODS: An intervention using the Promotora de Salud model was implemented in four U...
January 9, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28066832/antioxidant-supplements-and-semen-parameters-an-evidence-based-review
#13
REVIEW
Sedigheh Ahmadi, Reihane Bashiri, Akram Ghadiri-Anari, Azadeh Nadjarzadeh
Many studies have focused on male infertility. There is limited evidence about the influence of nutrition on quality of semen. Approximately, 30-80% of infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity. This study was aimed to review the effects of oral antioxidant supplements on improving major semen parameters such as sperm concentration, motility, morphology, DNA damage, and fertility rate. Data were extracted from PubMed and Google scholar database by using the terms "antioxidant", "multivitamin", "carnitine", "CoQ10", "vitamin C", "vitamin E", "zinc", "folic acid", "N-acetyl cysteine" and "selenium" combined with "male infertility", "semen", and "sperm" to generate a set of relevant citations...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28064499/poly-glycerol-used-for-constructing-mixed-polymeric-micelles-as-t1-mri-contrast-agent-for-tumor-targeted-imaging
#14
Yi Cao, Min Liu, Kunchi Zhang, Guangyue Zu, Ye Kuang, Xiaoyan Tong, Dangsheng Xiong, Renjun Pei
There was much interest in the development of nanoscale delivery vehicles based on polymeric micelles to realize the diagnostic and therapeutic applications in biomedicine. Here, with the purpose of constructing a micellar magnetic resonance imaging (MRI) contrast agent (CA) with well biocompatibility and targeting specificity, two types of amphiphilic diblock polymers, mPEG-PG(DOTA(Gd))-b-PCL and FA-PEG-b-PCL, were synthesized to form mixed micelles by coassembly. The nanostructure of the resulting micellar system consisted of poly(caprolactone) (PCL) as core and poly(glycerol) (PG) and poly(ethylene glycol) (PEG) as shell, simultaneously modified with DOTA(Gd) chelates and folic acid (FA), which afforded functions of MRI contrast enhancement and tumor targeting...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28063572/suppl%C3%A3-mentation-pr%C3%A3-conceptionnelle-en-acide-folique-multivitamines-pour-la-pr%C3%A3-vention-primaire-et-secondaire-des-anomalies-du-tube-neural-et-d-autres-anomalies-cong%C3%A3-nitales-sensibles-%C3%A3-l-acide-folique
#15
R Douglas Wilson
OBJECTIF: Offrir des renseignements à jour sur l'utilisation pré et postconceptionnelle d'acide folique par voie orale, avec ou sans supplément de multivitamines / micronutriments, aux fins de la prévention des anomalies du tube neural et d'autres anomalies congénitales. Ces renseignements aideront les médecins, les sages-femmes, les infirmières et les autres professionnels de la santé à contribuer aux efforts de sensibilisation des femmes quant à l'utilisation et aux posologies adéquates de la supplémentation en acide folique / multivitamines, avant et pendant la grossesse...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062893/prenatal-alcohol-induced-neuroapoptosis-in-rat-brain-cerebral-cortex-protective-effect-of-folic-acid-and-betaine
#16
Ibrahim Sogut, Onur Uysal, Aysegul Oglakci, Ferruh Yucel, Kazim Kartkaya, Gungor Kanbak
PURPOSE: Alcohol consumption in pregnancy may cause fetal alcohol syndrome (FAS) in the infant. This study aims to investigate prenatal alcohol exposure related neuroapoptosis on the cerebral cortex tissues of newborn rats and possible neuroprotective effects of betaine, folic acid, and combined therapy. METHODS: Pregnant rats were divided into five experimental groups: control, ethanol, ethanol + betaine, ethanol + folic acid, and ethanol + betaine + folic acid combined therapy groups...
January 6, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28058423/rapidly-cell-penetrating-and-reductive-milieu-responsive-nanoaggregates-assembled-from-an-amphiphilic-folate-camptothecin-prodrug-for-enhanced-drug-delivery-and-controlled-release
#17
Zhigang Xu, Meili Hou, Xiaoxiao Shi, Yong-E Gao, Peng Xue, Shiying Liu, Yuejun Kang
Accurate diagnosis and treatment based on small molecular prodrugs can enhance drug efficiency and reduce side-effects during cancer therapy. Herein, we report the preparation of a type of glutathione (GSH)-responsive small prodrug delivery system based on targeting folic acid (FA) and conjugating with the hydrophobic antitumor drug camptothecin (CPT) via disulfide bonds. The obtained prodrug is capable of high and precise drug loading (36.8 wt%) and can self-assemble into nanoaggregates with an average size of 46...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28057694/nutrition-modification-aimed-at-enhancing-dietary-iron-and-folic-acid-intake-an-application-of-health-belief-model-in-practice
#18
Marzieh Araban, Khadije Baharzadeh, Mahmood Karimy
BACKGROUND: The amount of calories and nutrients required for woman increase during pregnancy and Intake adequate amounts of nutrients is essential for the health of mother and foetal. This study was designed to investigate the effect of nutrition education based on the Health Belief Model (HBM) on calories, iron and folic acid intake for pregnant women. METHODS: This quasi-experimental study was performed on 76 pregnant women referring to four urban health centres of Khuzestan at 2015...
January 4, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28057107/-risk-factors-for-prevalence-of-folic-acid-deficiency-in-chinese-lactating-women-in-2013
#19
Y Bi, Y F Duan, J Wang, D M Yu, X G Yang, S A Yin, Z Y Yang
Objective: The study aimed to assess the folic acid status of lactating women in China and to analyze factors related to folic acid deficiency in these subjects. Methods: The data on lactating women were extracted from the Chinese National Nutrition and Health Surveillance in 2013. By a multi-stage stratified cluster random sampling method, 10 331 lactating women were selected for the study. The lactating women, 0-24 months postpartum, were from 55 sites in 30 provinces of China, excluding the Tibet Autonomous Region...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28056002/announcement-national-birth-defects-prevention-month-and-folic-acid-awareness-week-january-2017
#20
(no author information available yet)
The Zika virus disease outbreak has led to renewed focus on how some birth defects are caused by infection during pregnancy. "Prevent Infections for Baby's Protection" is the theme of January 2017's National Birth Defects Prevention Month. Birth defects are common, costly, and critical, and they affect one in 33 U.S. babies annually (1). Not all birth defects can be prevented, but women can increase their chances of having a healthy baby by reducing their risk for getting an infection during pregnancy.
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
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