keyword
https://read.qxmd.com/read/38207008/incidence-correlates-and-prognostic-significance-of-mixed-response-in-advanced-non-small-cell-lung-cancer
#21
JOURNAL ARTICLE
David E Gerber, Yating Wang, Suresh S Ramalingam, Sheena Bhalla, Zhuoxin Sun, Hossein Borghaei, Julie R Brahmer, Joan H Schiller
BACKGROUND: Mixed response (MR), a scenario featuring discordant tumor changes, has been reported primarily with targeted therapies or immunotherapy. We determined the incidence and prognostic significance of MR in advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy. PATIENTS AND METHODS: We analyzed patient-level data from ECOG-ACRIN E5508 (carboplatin-paclitaxel + bevacizumab induction followed by randomization to maintenance therapy regimens)...
January 11, 2024: Oncologist
https://read.qxmd.com/read/38181521/artery-to-vein-anastomoses-in-unequally-divided-placentas-and-their-association-with-birthweight-discordance
#22
JOURNAL ARTICLE
A T R Noll, F C Lof, S G Groene, M C Haak, E Lopriore, F M Russo, F Slaghekke, L S A Tollenaar, J Van der Merwe, E J T Verweij, L Lewi
INTRODUCTION: This study investigated the impact of the shared intertwin circulation in unequally divided monochorionic (MC) placentas on fetal growth. METHODS: This retrospective analysis included color-dyed, unequally shared placentas from two tertiary centers. Exclusions included twin-twin transfusion syndrome, twin anemia polycythemia sequence, and lethal anomalies. Measurement of the external diameters and areas of the artery-to-artery (AA), artery-to-vein (AV), and vein-to-vein (VV) anastomoses was performed...
February 2024: Placenta
https://read.qxmd.com/read/38167612/distinct-patterns-of-proteostasis-network-gene-expression-are-associated-with-different-prognoses-in-melanoma-patients
#23
JOURNAL ARTICLE
Rachel Wellman, Daniel Jacobson, Maria Secrier, John Labbadia
The proteostasis network (PN) is a collection of protein folding and degradation pathways that spans cellular compartments and acts to preserve the integrity of the proteome. The differential expression of PN genes is a hallmark of many cancers, and the inhibition of protein quality control factors is an effective way to slow cancer cell growth. However, little is known about how the expression of PN genes differs between patients and how this impacts survival outcomes. To address this, we applied unbiased hierarchical clustering to gene expression data obtained from primary and metastatic cutaneous melanoma (CM) samples and found that two distinct groups of individuals emerge across each sample type...
January 2, 2024: Scientific Reports
https://read.qxmd.com/read/38166739/predictive-value-of-maternal-serum-placental-growth-factor-levels-for-discordant%C3%A2-fetal-growth%C3%A2-in-twins-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Shuai Li, Kaiqi Wu, Shaomin Zhou, Binbin Yin, Xiaoxia Bai, Bo Zhu
BACKGROUND: Accurate prenatal recognition of discordant fetal growth in twins is critical for deciding suitable management strategies. We explored the predictive value of the level of maternal second-trimester placental growth factor (PLGF) as a novel indicator of discordant fetal growth. METHODS: A total of 860 women pregnant with twins were enrolled, including 168 women with monochorionic twins (31 cases of discordant fetal growth and 137 without) and 692 with dichorionic twins (79 cases of discordant fetal growth and 613 without)...
January 2, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38156737/color-standardization-and-stain-intensity-calibration-for-whole-slide-image-based-immunohistochemistry-assessment
#25
JOURNAL ARTICLE
Chie Ohnishi, Takashi Ohnishi, Kareem Ibrahim, Peter Ntiamoah, Dara Ross, Masahiro Yamaguchi, Yukako Yagi
Automated quantification of human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) using whole slide imaging (WSI) is expected to eliminate subjectivity in visual assessment. However, the color intensity in WSI varies depending on the staining process and scanner device. Such variations affect the image analysis results. This paper presents methods to diminish the influence of color variation produced in the staining process using a calibrator slide consisting of peptide-coated microbeads...
December 29, 2023: Microscopy and Microanalysis
https://read.qxmd.com/read/38094527/exploring-the-attitudes-of-medical-students-towards-social-media-and-e-professionalism-in-al-ahsa-saudi-arabia
#26
JOURNAL ARTICLE
Saba Firdos, Sarah Almulla, Sarah Aldossary, Sarra Al Hassan, Latifah Aldhaif
Background In the digital age, social media is essential to everyone's life, including medical students. The rapid proliferation and updates in social media make this platform more attractive and accessible. However, online behavior and guidelines have always been a topic of ongoing debate. Thus, the study's objectives were to investigate the usage of social networking sites for various intentions among medical students, their opinions about applying these platforms for educational benefits, and their perception and accountability for e-professionalism...
November 2023: Curēus
https://read.qxmd.com/read/38071286/morphologic-phenotypic-and-genotypic-similarities-between-primary-tumors-and-corresponding-3d-cell-cultures-grown-in-a-repeatable-system-preliminary-results
#27
JOURNAL ARTICLE
Luisa Vera Muscatello, Stella Frabetti, Giancarlo Avallone, Francesca Gobbo, Arianna Pasquini, Giulia D'Annunzio, Luciano Pisoni, Laura Marconato, Rossella Terragni, Dario De Biase, Olivia Candini, Giuseppe Sarli
BACKGROUND: Three-dimensional (3D) cell cultures are the new frontier for reproducing the tumor micro-environment in vitro. The aims of the study were (1) to establish primary 3D cell cultures from canine spontaneous neoplasms and (2) to demonstrate the morphological, phenotypic and genotypic similarities between the primary canine neoplasms and the corresponding 3D cultures, through the expression of tumor differentiation markers. RESULTS: Seven primary tumors were collected, including 4 carcinomas and 3 soft tissue sarcomas...
December 9, 2023: BMC Veterinary Research
https://read.qxmd.com/read/38051049/-salmonella-actively-modulates-tfeb-in-murine-macrophages-in-a-growth-phase-and-time-dependent-manner
#28
JOURNAL ARTICLE
Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H Choy, Joseph B McPhee, Roberto J Botelho
Activation of the host transcription factor TFEB helps mammalian cells adapt to stresses such as starvation and infection by upregulating lysosome, autophagy, and immuno-protective gene expression. Thus, TFEB is generally thought to protect host cells. However, it may also be that pathogenic bacteria like Salmonella orchestrate TFEB in a spatio-temporal manner to harness its functions to grow intracellularly. Indeed, the relationship between Salmonella and TFEB is controversial since some studies showed that Salmonella actively promotes TFEB, while others have observed that Salmonella degrades TFEB and that compounds that promote TFEB restrict bacterial growth...
December 5, 2023: Microbiology Spectrum
https://read.qxmd.com/read/38039422/evaluating-the-impact-of-maternal-exposure-to-ozone-on-twin-fetal-growth-in-china
#29
JOURNAL ARTICLE
Yang Shen, Hongping Zhang, Shenpeng Wu, Jing Dong, Huimin Li, Ying Yang, Jihong Xu, Ya Zhang, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Lifang Jiang, Xueyi Xu, Guangbin Quan, Xia Meng, Yuan He, Jing Cai, Haidong Kan, Xu Ma
Unlike singletons, twins require attention not only to the birth weight of the fetuses but also to discordance (i.e., the differences between weights) because twin growth discordance is a significant factor contributing to perinatal mortality and morbidity in twin pregnancies. However, the impact of maternal air pollution exposure on twin growth discordance has rarely been investigated. We examined the association of long-term ozone exposure during preconception and pregnancy with the birth weight of twins and twin growth discordance among 35,795 twins from the National Free Preconception Health Examination Project between January 2010 and December 2019...
December 1, 2023: Environmental Science & Technology
https://read.qxmd.com/read/38010306/fingerprint-patterns-in-relation-to-an-altered-neurodevelopment-in-patients-with-autism-spectrum-disorder
#30
JOURNAL ARTICLE
Klaudia Kyselicová, Dóra Dukonyová, Ivan Belica, Dominika Sónak Ballová, Viktória Jankovičová, Daniela Ostatníková
Dermatoglyphic patterns are permanently established and matured before the 24th week of gestation. Their frequencies and localization might be a good indicator of developmental instability in individuals with an altered neurodevelopment and show potential as biomarkers of autism spectrum disorder (ASD). In this study, fingerprint pattern counts and fluctuating asymmetry in the distribution of patterns are compared between 67 boys diagnosed with ASD (aged 5.11 ± 2.51 years) and 83 control boys (aged 8...
December 2023: Developmental Psychobiology
https://read.qxmd.com/read/37998589/impact-of-variation-between-assays-and-reference-intervals-in-the-diagnosis-of-endocrine-disorders
#31
REVIEW
Nathan Lorde, Ahmed Elgharably, Tejas Kalaria
Method-related variations in the measurement of hormones and the reference intervals used in the clinical laboratory can have a significant, but often under-appreciated, impact on the diagnosis and management of endocrine disorders. This variation in laboratory practice has the potential to lead to an errant approach to patient care and thus could cause harm. It may also be the source of confusion or result in excessive or inadequate investigation. It is important that laboratory professionals and clinicians know about these impacts, their sources, and how to detect and mitigate them when they do arise...
November 16, 2023: Diagnostics
https://read.qxmd.com/read/37982632/phenotype-versus-genotype-discordant-rifampicin-susceptibility-testing-in-tuberculosis-implications-for-a-diagnostic-accuracy
#32
JOURNAL ARTICLE
Mehmood Qadir, Rani Faryal, Muhammad Tahir Khan, Sajjad Ahmed Khan, Shulin Zhang, Weimin Li, Dong Qing Wei, Sabira Tahseen, Timothy D McHugh
An accurate diagnosis of drug resistance in clinical isolates is an important step for better treatment outcomes. The current study observed a higher discordance rate of rifampicin resistance on Mycobacteria Growth Indicator Tube (MGIT) drug susceptibility testing (DST) than Lowenstein-Jenson (LJ) DST when compared with the rpoB sequencing. We detected a few novel mutations and their combination in rifampicin resistance isolates that were missed by MGIT DST and may be useful for the better management of tuberculosis (TB) treatment outcomes...
November 20, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37977835/pulmonary-sclerosing-pneumocytoma-approaching-a-solitary-pulmonary-nodule-and-the-limitations-of-risk-prediction-models
#33
JOURNAL ARTICLE
Kundan Reddy Saripalli, Mark Qi Wei Wang, Chun Yuen Chow, Si Yuan Chew
Our case is an asymptomatic, non-smoking, East Asian woman in her 40s presenting with a solitary pulmonary nodule (SPN). On imaging, the 1.7 cm solid SPN located in the left upper lobe, was rounded in morphology and moderately fluorodeoxyglucose avid. The clinical pretest probability of malignancy assessed by risk prediction models such as Brock (19.1%), Mayo Clinic (56.2%) and Herder (51.4%) was discordant. She underwent a percutaneous CT-guided needle biopsy, establishing a diagnosis of pulmonary sclerosing pneumocytoma (PSP)...
November 17, 2023: BMJ Case Reports
https://read.qxmd.com/read/37976061/antenatal-corticosteroid-treatment-during-the-late-preterm-period-and-neonatal-outcomes-for-twin-pregnancies
#34
JOURNAL ARTICLE
Jie Zhu, Ying Zhao, Ping An, Yunhe Zhao, Shuyue Li, Jizi Zhou, Huanqiang Zhao, Qiongjie Zhou, Xiaotian Li, Yu Xiong
IMPORTANCE: Antenatal corticosteroid treatment of individuals with singletons at risk for delivery during the late-preterm period has been academically recommended. However, the evidence on the use of antenatal corticosteroid treatment for twins at risk for delivery during the late-preterm period is still lacking. OBJECTIVE: To evaluate whether antenatal corticosteroid treatment during the late-preterm period in twin pregnancies was associated with a lower risk of newborn morbidity...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37958354/human-epidermal-growth-factor-receptor-2-gastric-adenocarcinoma-expanding-therapy-of-a-recognized-target
#35
REVIEW
Jane E Rogers, Kohei Yamashita, Matheus Sewastjanow-Silva, Allison Trail, Rebecca E Waters, Jaffer Ajani
Human epidermal growth factor receptor-2 (HER2) is a well-known cancer target. Many HER2-targeted agents are marketed and being investigated. Unfortunately, these therapies lack consistent responses and outcomes amongst different tumors. Questions remain as to why HER2 biology is different in different tumor types. Gastric adenocarcinomas (GACs) demonstrate both intra- and inter-tumor HER2 expression heterogeneity and show discordance amongst primary and metastatic disease sites. This creates barriers in determining HER2 agents' effectiveness and contributes to the failure of some HER2-targeted agents in the treatment of HER2-positive advanced GACs...
October 27, 2023: Cancers
https://read.qxmd.com/read/37948078/comorbid-prolonged-grief-ptsd-and-depression-trajectories-for-bereaved-family-surrogates
#36
JOURNAL ARTICLE
Fur-Hsing Wen, Holly G Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang, Siew Tzuh Tang
IMPORTANCE: Family surrogates of patients who die in an intensive care unit (ICU) are at risk of cooccurring prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depressive disorder during bereavement, but symptom trajectories are often explored individually. OBJECTIVES: To simultaneously examine and determine co-occurrence of PGD, PTSD, and depressive symptom trajectories. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted in ICUs of 2 Taiwanese medical centers from January 2018 to March 2020, with follow-up through July 2022...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37942416/thick-artery-artery-anastomoses-delay-the-onset-of-selective-fetal-growth-restriction-in-monochorionic-diamniotic-twins-a-7-year-single-center-cohort-study
#37
JOURNAL ARTICLE
Xueju Wang, Luyao Li, Pengbo Yuan, Yangyu Zhao, Yuan Wei
OBJECTIVE: This study aimed to investigate differences in placental characteristics between early- and late-onset selective fetal growth restriction (sFGR) in monochorionic diamniotic twins. METHODS: A total of 253 patients with sFGR between April 2013 and April 2020 were retrospectively analyzed. Placental characteristics of early- and late-onset sFGR were compared. RESULTS: The gestational age at diagnosis and delivery in the early-onset group was significantly less than that in the late-onset group [22...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37934897/the-role-of-estimated-fetal-weight-discordance-in-dichorionic-twin-pregnancies
#38
JOURNAL ARTICLE
Mateusz Kryczka, Mateusz G Stepien, Wlodzimierz Sawicki
Evaluation of relative fetal growth in the form of estimated fetal weight discordance (EFWd) is a necessary element of any ultrasound examination in twin pregnancies. It is one of the criteria for the diagnosis of selective fetal growth restriction (sFGR) according to the most established worldwide guidelines. Apart from the effectiveness of this parameter for the diagnosis of sFGR, it may also be used as an independent factor for risk stratification of neonatal and maternal complications. Furthermore, numerous studies have proven the greater prognostic value of EFWd in dichorionic pregnancies, which may result from differences in the pathogenesis of fetal growth abnormalities in mono- and dichorionic pregnancies...
November 7, 2023: Ginekologia Polska
https://read.qxmd.com/read/37931185/overall-survival-with-circulating-tumor-cell-count-driven-choice-of-therapy-in-advanced-breast-cancer-a-randomized-trial
#39
RANDOMIZED CONTROLLED TRIAL
François-Clément Bidard, Nicolas Kiavue, William Jacot, Thomas Bachelot, Sylvain Dureau, Hugues Bourgeois, Anthony Goncalves, Etienne Brain, Sylvain Ladoire, Florence Dalenc, Joseph Gligorov, Luis Teixeira, George Emile, Jean-Marc Ferrero, Delphine Loirat, Luc Cabel, Amir Kadi, Véronique Diéras, Catherine Alix-Panabières, Jean-Yves Pierga
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported .In patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer, the STIC CTC trial established that, for choosing between endocrine therapy (ET) or chemotherapy, the use of circulating tumor cell (CTC) count is noninferior to the investigator's choice in terms of progression-free survival...
February 1, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/37920852/case-report-paternal-uniparental-disomy-on-chromosome-7-and-homozygous-sugct-mutation-in-a-fetus-with-overweight-after-birth
#40
Xiufen Bu, Xu Li, Can Peng, Hongyu Li, Shihao Zhou, Zesen Zhu, Jun He, Siyuan Linpeng
Background: Paternal uniparental disomy (UPD) of chromosome 7 is extremely rare, and only a few postnatal cases have been reported. The effects on growth were discordant in these cases, and the relevance of paternal UPD(7) to growth caused by imprinting remains questionable. Case presentation: Here, we report a prenatal case that underwent invasive prenatal diagnosis due to the high risk of Down's syndrome and failed noninvasive prenatal screening. The fetus had a normal karyotype and no apparent copy number variation...
2023: Frontiers in Genetics
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