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https://www.readbyqxmd.com/read/28437586/pathogenesis-of-vascular-leak-in-dengue-virus-infection
#1
REVIEW
Gathsaurie Neelika Malavige, Graham S Ogg
Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular leak typically becomes clinically evident during 3-6 days since the onset of illness, which is known as the critical phase. This critical phase follows the period of peak viraemia, and lasts for 24 to 48 hours and usually shows rapid and complete reversal, suggesting it is likely to occur as a result of inflammatory mediators, rather than infection of the endothelium. Cytokines such as TNFα, which are known to be elevated in the critical phase of dengue, are likely to be contributing factors...
April 24, 2017: Immunology
https://www.readbyqxmd.com/read/28432840/detection-of-egfr-mutations-in-patients-with-non-small-cell-lung-cancer-by-high-resolution-melting-comparison-with-other-methods
#2
Carlos Martínez-Carretero, Fernando Iguaz Pascual, Antonio Rus, Ivan Bernardo
BACKGROUND: The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensitivity and potential ability to detect a different number of mutations. METHODS: We developed a screening method by high resolution melting (HRM) to detect EGFR mutations, and compared the results of 123 fixed in formalin and paraffin embedded (FFPE) tumor tissue samples with the detection of mutations by allele-specific PCR...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28430631/loss-of-steroid-hormone-receptors-is-common-in-malignant-pleural-and-peritoneal-effusions-of-breast-cancer-patients-treated-with-endocrine-therapy
#3
Willemijne A M E Schrijver, Karianne Schuurman, Annelot van Rossum, Ton Peeters, Natalie Ter Hoeve, Wilbert Zwart, Paul J van Diest, Cathy B Moelans
Discordance in estrogen receptor alpha (ERα), progesterone receptor (PR), androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) status between primary breast cancers and solid distant metastases ("conversion") has been reported previously. Even though metastatic spread to the peritoneal and pleural cavities occurs frequently and is associated with high mortality, the rate of receptor conversion and the prognostic implications thereof remain elusive.We therefore determined receptor conversion in 91 effusion metastases (78 pleural, 13 peritoneal effusions) of 69 patients by immunohistochemistry (IHC) and in situ hybridization...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425758/agreement-between-mri-and-pathologic-analyses-for-determination-of-tumor-size-and-correlation-with-immunohistochemical-factors-of-invasive-breast-carcinoma
#4
Eun Young Yoo, Sang Yu Nam, Hye-Young Choi, Min Ji Hong
Background There may be discordance between tumor size determined by magnetic resonance imaging (MRI) and that observed during pathologic analyses. Purpose To evaluate MRI-pathology concordance of tumor size in patients with invasive breast carcinoma. Material and Methods Data from 307 invasive breast carcinomas were analyzed retrospectively. Preoperative breast MRI was reviewed for size, lesion type, morphology, and dynamic contrast-enhanced tumor kinetics. MRI tumor size was compared with tumor size measurements from the pathologic analysis...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28414009/adenosine-triphosphate-quantification-correlates-poorly-with-microbial-contamination-of-duodenoscopes
#5
Lovisa B Olafsdottir, Sharon B Wright, Anne Smithey, Riley Heroux, Elizabeth B Hirsch, Alice Chen, Benjamin Lane, Mandeep S Sawhney, Graham M Snyder
OBJECTIVE The aim of this study was to quantify the correlation between adenosine triphosphate (ATP) measurements and bacterial cultures from duodenoscopes for evaluation of contamination following high-level disinfection. DESIGN Duodenoscopes used for any intended endoscopic retrograde cholangiopancreatography (ERCP) procedure were included. Microbiologic and ATP data were collected concomitantly and in the same manner from ERCP duodenoscopes. SETTING A high-volume endoscopy unit at a tertiary referral acute-care facility...
April 17, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28401821/-70-gene-signature-as-an-aid-to-treatment-decisions-in-early-stage-breast-cancer
#6
J J M van der Hoeven
OBJECTIVE: The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy. METHODS: In this randomized, phase 3 study, we enrolled 6693 women with early-stage breast cancer and determined their genomic risk (using the 70-gene signature) and their clinical risk (using a modified version of Adjuvant! Online)...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28387315/genome-wide-identification-and-functional-prediction-of-cold-and-or-drought-responsive-lncrnas-in-cassava
#7
Shuxia Li, Xiang Yu, Ning Lei, Zhihao Cheng, Pingjuan Zhao, Yuke He, Wenquan Wang, Ming Peng
Cold and drought stresses seriously affect cassava (Manihot esculenta) plant growth and yield. Recently, long noncoding RNAs (lncRNAs) have emerged as key regulators of diverse cellular processes in mammals and plants. To date, no systematic screening of lncRNAs under abiotic stress and their regulatory roles in cassava has been reported. In this study, we present the first reference catalog of 682 high-confidence lncRNAs based on analysis of strand-specific RNA-seq data from cassava shoot apices and young leaves under cold, drought stress and control conditions...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28355685/-clinical-outcome-and-placenta-characteristics-of-spontaneous-twin-anemia-polycythemia-sequence
#8
X J Wang, L Y Li, Y Wei, Y Y Zhao, P B Yuan
Objective: To investigate the clinical outcome and placental characteristics of spontaneous twin anemia-polycythemia sequence (sTAPS). Methods: Twelve cases with sTAPS delivered in Peking University Third Hospital from May 2013 to August 2016. The data of ultrasound characteristics, gestational age at delivery, and 1 minute Apgar score were analyzed, retrospectively. Placental superficial vascular anastomoses, placental territory discordance and the ratio of umbilical cords insertion distance to the longest placental diameter were also analyzed...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28348386/perinatal-risk-factors-in-tourette-s-and-chronic-tic-disorders-a-total-population-sibling-comparison-study
#9
G Brander, M Rydell, R Kuja-Halkola, L Fernández de la Cruz, P Lichtenstein, E Serlachius, C Rück, C Almqvist, B M D'Onofrio, H Larsson, D Mataix-Cols
Adverse perinatal events may increase the risk of Tourette's and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed to prospectively investigate potential perinatal risk factors for TD/CTD, taking unmeasured factors shared between full siblings into account. A population-based birth cohort, consisting of all singletons born in Sweden in 1973-2003, was followed until December 2013. A total of 3 026 861 individuals were identified, 5597 of which had a registered TD/CTD diagnosis...
March 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28341329/body-mass-index-and-insulin-like-growth-factor-1-as-risk-factors-for-discordant-growth-hormone-and-insulin-like-growth-factor-1%C3%A2-levels-following-pituitary-surgery-in-acromegaly
#10
Shuo Zhang, Yilin Li, Xiaopeng Guo, Lu Gao, Wei Lian, Yong Yao, Ming Feng, Xinjie Bao, Renzhi Wang, Bing Xing
BACKGROUND: Growth hormone (GH)-secreting pituitary adenoma is a chronic disease characterized by excess levels of GH and insulin-like growth factor 1 (IGF-1). Based on our clinical experience and observations, we identified discordant GH and IGF-1 levels after surgery. The risk factors for this phenomenon are unclear, and individualized cure, control criteria, and management after surgery should be considered. PURPOSE: This study aims to investigate the factors affecting the discordant GH and IGF-1 levels after pituitary surgery in acromegalic patients...
March 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28332074/matrix-metalloproteinase-2-mmp-2-levels-are-increased-in-active-acromegaly-patients
#11
Alper Cagri Karci, Zeynep Canturk, Ilhan Tarkun, Berrin Cetinarslan
PURPOSE: During follow-up of acromegaly patients, there is a discordance rate of 30% between the measurements of growth hormone and insulin-like growth factor-1 levels. Further tests are required to determine disease activity in patients with discordant results. This study was planned to investigate an association of serum levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B with disease activity in acromegaly patients. METHODS: In this study, 64 acromegaly patients followed in our clinic were divided into two groups according to the 2010 consensus criteria for cure of acromegaly as patients with active disease (n = 24) and patients with controlled disease (n = 40)...
March 22, 2017: Endocrine
https://www.readbyqxmd.com/read/28306538/leptin-and-adiponectin-levels-in-discordant-dichorionic-twins-at-72-hours-of-age-associations-with-anthropometric-parameters-and-insulin-resistance
#12
Svetlana J Milenković, Ljiljana B Mirković, Miljana Z Jovandarić, Dušan M Milenković, Violeta V Banković, Borisav Z Janković
BACKGROUND: Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested. METHODS: We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins. RESULTS: A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0...
April 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28303777/placental-up-regulation-of-leptin-and-arms2-is-associated-with-growth-discordance-in-monochorionic-diamniotic-twin-pregnancies
#13
Luming Sun, Jia Zhou, Kai Wang, Jian Wang, Ling Shang, Jianguang Zhang, Junqing Wu, David S Cram
Fetal growth discordance is a relatively common complication of monochorionic diamniotic (MCDA) twin pregnancies and is caused by a combination of maternal and placental factors. The aim of the study was to survey placental gene expression patterns and identify genes associated with growth discordance. Clinical samples comprised eight growth-discordant MCDA twin placentas (31+3-34+4 weeks gestational age) and six growth-concordant twin placentas (31+2-37 weeks gestational age). Gene expression libraries were constructed from placental biopsy samples and analyzed by RNA-sequencing...
April 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28283267/comparison-of-cytogenetics-and%C3%A2-molecular-karyotyping-for%C3%A2-chromosome-testing-of-miscarriage-specimens
#14
Meera Sridhar Shah, Cengiz Cinnioglu, Melissa Maisenbacher, Ioanna Comstock, Jonathan Kort, Ruth Bunker Lathi
OBJECTIVE: To compare chromosome testing of miscarriage specimens between traditional cytogenetic analysis and molecular karyotyping using single nucleotide polymorphism microarrays (SNP) and array comparative genomic hybridization (aCGH). DESIGN: Prospective blinded cohort study. SETTING: University-based practice. PATIENT(S): Women undergoing dilation and curettage for first-trimester miscarriage between March 2014 and December 2015...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28277911/fetal-growth-pathology-score-a-novel-ultrasound-parameter-for-individualized-assessment-of-third-trimester-growth-abnormalities
#15
Russell L Deter, Wesley Lee, John C P Kingdom, Roberto Romero
OBJECTIVES: To study fetal growth in pregnancies at risk for growth restriction using, for the first time, the Fetal Growth Pathology Score [FGPS1]. METHODS: A retrospective cohort study of growth restriction [GR] was carried out in 184 selected SGA singletons using a novel, composite measure of growth abnormalities termed the FGPS1. Serial fetal biometry was used to establish 2(nd) trimester Rossavik size models and determine FGPS1 values prior to delivery. FGPS1 data were compared to neonatal growth outcomes assessed using Growth Potential Realization Index [GPRI] values [average negative pathological GPRI {av -pGPRI}]...
March 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28254226/preliminary-report-of-altered-insulin-secretion-pattern-in-monochorionic-twin-pregnancies-complicated-with-selective-intrauterine-growth-restriction
#16
Yao-Lung Chang, Tzu-Hao Wang, Seham M Abufraijeh, Shuenn-Dyh Chang, An-Shine Chao, Peter C C Hsieh
OBJECTIVE: Fetuses with intrauterine growth restriction (IUGR) have adaptive hormonal changes including changes in insulin, which may increase their future risks for developing diabetes mellitus. This study compared cord blood insulin concentrations in IUGR and appropriate for gestational age (AGA) fetuses in a monochorionic (MC) twin model. MATERIALS AND METHODS: Ten pairs were classified as selective IUGR (sIUGR) based on having one twin weight below the 10th percentile and with an intertwin birth weight discordance>20%...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28244460/alteration-in-steroid-hormone-and-her-2-neu-receptor-status-following-neoadjuvant-chemotherapy-in-locally-advanced-breast-cancer-experience-at-a-tertiary-care-centre-in-india
#17
P Ramteke, V Seenu, R Prashad, S D Gupta, V Iyer, Svs Deo, A Gogia, S Mathur
CONTEXT: Use of neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) enables tumor reduction and conservative surgery. It is proposed in some studies that there may be an alteration in the hormonal receptor (HR) status and human epidermal growth factor receptor 2 (Her-2)/neu immune-expression following NACT. AIMS: To study the status of estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu receptor before and after NACT in LABC. MATERIALS AND METHODS: HR and Her-2/neu status were evaluated by immunohistochemistry on 100 core needle biopsy of primary tumors and surgical specimens after receiving NACT (NACT group); fifty patients without NACT served as non-NACT group, and discordance was compared between the two groups...
July 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28220482/morphological-interaction-between-the-nasal-septum-and-nasofacial-skeleton-during-human-ontogeny
#18
Matthew J Goergen, Nathan E Holton, Thorsten Grünheid
The nasal septal cartilage is thought to be a key growth center that contributes to nasofacial skeletal development. Despite the developmental influence of the nasal septum however, humans often exhibit a high frequency of septal deviation suggesting discordance in the growth between the septum and surrounding nasofacial skeleton. While there are numerous etiological factors that contribute to septal deviation, the surrounding nasofacial skeleton may also act to constrain the septum, resulting in altered patterns of growth...
February 20, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28205414/avoidance-of-maternal-cell-contamination-and-overgrowth-in-isolating-fetal-chorionic-villi-mesenchymal-stem-cells-from-human-term-placenta
#19
Varda S Sardesai, Abbas Shafiee, Nicholas M Fisk, Rebecca A Pelekanos
Human placenta is rich in mesenchymal stem/stromal cells (MSC), with their origin widely presumed fetal. Cultured placental MSCs are confounded by a high frequency of maternal cell contamination. Our recent systematic review concluded that only a small minority of placental MSC publications report fetal/maternal origin, and failed to discern a specific methodology for isolation of fetal MSC from term villi. We determined isolation conditions to yield fetal and separately maternal MSC during ex vivo expansion from human term placenta...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28168377/biochemical-investigations-in-diagnosis-and-follow-up-of-acromegaly
#20
REVIEW
Katharina Schilbach, Christian J Strasburger, Martin Bidlingmaier
Measurements of human growth hormone (GH) and insulin-like growth-factor I (IGF-I) are cornerstones in the diagnosis of acromegaly. Both hormones are also used as biochemical markers in the evaluation of disease activity during treatment. Management of acromegaly is particularly challenging in cases where discordant information is obtained from measurement of GH concentrations following oral glucose load and from measurement of IGF-I. While in some patients biological factors can explain the discrepancy, in many cases issues with the analytical methods seem to be responsible...
February 2017: Pituitary
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