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Growth discordance

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https://www.readbyqxmd.com/read/29315431/receptor-conversion-in-distant-breast-cancer-metastases-a-systematic-review-and-meta-analysis
#1
Willemijne A M E Schrijver, Karijn P M Suijkerbuijk, Carla H van Gils, Elsken van der Wall, Cathy B Moelans, Paul J van Diest
Background: In metastatic breast cancer, hormone and/or human epidermal growth factor receptor 2 (HER2)-targeted therapy decision-making is still largely based on tissue characteristics of the primary tumor. However, a change of estrogen receptor alpha (ERα), progesterone receptor (PR), and HER2 status in distant metastases has frequently been reported. The actual incidence of this phenomenon has been debated. Methods: We performed a meta-analysis including 39 studies assessing receptor conversion from primary breast tumors to paired distant breast cancer metastases...
January 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29314091/the-relationship-between-preoperative-fetal-head-circumference-and-2-year-cognitive-performance-after-laser-surgery-for-twin-twin-transfusion-syndrome
#2
Andrew H Chon, Mary Rose Mamey, Sheree M Schrager, Douglas L Vanderbilt, Ramen H Chmait
OBJECTIVE: To determine the relationship between preoperative fetal head circumference (HC) and cognitive performance among children treated with laser surgery for twin-twin transfusion syndrome (TTTS). METHODS: Donor and recipient twin HCs were measured preoperatively (16 - 26 weeks' gestation) and at 2 years corrected age. Multilevel multivariate regression models were used to test pregnancy and child-level risk factors for lower Battelle Developmental Inventory 2nd Edition (BDI-2) scores...
January 4, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29301441/use-of-the-fetal-myocardial-performance-index-in-monochorionic-diamniotic-twin-pregnancy-a-prospective-cohort-and-nested-case-control-study
#3
Amanda Henry, Saranya Gopikrishna, Aditi Mahajan, Jennifer Alphonse, Neama Meriki, Alec W Welsh
AIMS: Assess clinical utility of the fetal Myocardial Performance Index (MPI) in evaluation and management of monochorionic, diamniotic twin (MCDA) pregnancies. METHODS: Prospective cohort of a) initially uncomplicated MCDA b) Complicated MCDA, including twin-twin transfusion syndrome (TTTS), selective intrauterine growth restriction (sIUGR), and liquor and/or growth discordance (L/GD) not meeting TTTS or sIUGR criteria. TTTS and sIUGR were case-control matched...
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29286910/selective-iugr-in-dichorionic-twins-what-can-doppler-assessment-and-growth-discordancy-say-about-neonatal-outcomes
#4
Paola Algeri, Matteo Frigerio, Maria Lamanna, Petya Vitanova Petrova, Sabrina Cozzolino, Maddalena Incerti, Salvatore Andrea Mastrolia, Nadia Roncaglia, Patrizia Vergani
OBJECTIVE: The aim of the present study was to assess, in a population of dichorionic twin pregnancies with selective growth restriction, the effect of inter-twin differences by use of Doppler velocimetry and fetal growth discordancy on perinatal outcomes. METHODS: This was a retrospective study including dichorionic twin pregnancies from January 2008 to December 2015 at the Department of Obstetrics and Gynecology of Fondazione MBBM. Only dichorionic twin pregnancies affected by selective intrauterine growth restriction (IUGR) delivering at ≥24 weeks were included in the study...
December 29, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29281478/assessment-of-treatment-patterns-for-metastatic-renal-cell-carcinoma-in-brazil
#5
Paulo G Bergerot, Cristiane D Bergerot, Nazli Dizman, Stenio Zequi, Andre Fay, Yash Dara, Manuel Caitano Maia, Brendan N Cotta, Edna Prado Gonçalves, Maria Nirvana Formiga, Milena Shizue Tariki, Diego Abreu Clavijo, Toni K Choueiri, Gilberto Lopes, Sumanta K Pal
Background Although multiple therapies have emerged for the treatment of metastatic renal cell carcinoma (mRCC), it is unclear whether application of these agents is consistent in developed and developing countries. We sought to determine patterns of care for mRCC in Brazil as a representative developing country. Material and Methods A commercial database was used to acquire information pertaining to patients with mRCC receiving treatment at private or public hospitals in Brazil between March 2013 and October 2016...
December 27, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29260362/discordances-in-er-pr-and-her2-between-primary-breast-cancer-and-brain-metastasis
#6
Jaehag Jung, Seung Hoon Lee, Mira Park, Ji Hye Youn, Sang Hoon Shin, Ho Shin Gwak, Heon Yoo
When distant metastases are discovered, it is important to determine receptor profiles of these lesions through histologic examination. However, brain metastasis sites are difficult to reach to be routinely biopsied. The purpose of this study was to determine expression profiles of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in breast cancer brain metastasis (BCBM) and the existence of discordance between primary breast cancer and brain metastasis...
December 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29238730/interaction-of-pubertal-development-and-metabolic-control-in-adolescents-with-type-1-diabetes-mellitus
#7
M Plamper, B Gohlke, J Woelfle, K Konrad, T Rohrer, S Hofer, W Bonfig, K Fink, R W Holl
Background: In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective: To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods: Using a large multicentre database, longitudinal data from 1294 patients were analysed. Inclusion criteria: complete records of height and HbA1c from the age of seven to 16 years. Exclusion criteria: other significant chronic diseases and medications, T1DM duration less than three months, and initial BMI < 3rd or >97th percentile...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238231/adverse-maternal-outcomes-and-birth-weight-discordance-in-twin-gestation-british-columbia-canadian-data
#8
Shayesteh Jahanfar, Kenneth Lim
Objective: The aim of this study was to determine whether twin pregnancies with birth weight discordance were associated with higher rates of maternal morbidities. Study design: A large retrospective population-based cohort study of twins born in British Columbia, Canada, from 2000 to 2010 was performed. Maternal morbidities and growth discordant were evaluated. Results: There were 6,328 twin deliveries during the study period. Pregnancies carrying growth-discordant twins had higher frequencies of hypertension disorders, preterm labor, and cesarean delivery compared with growth-concordant twins...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29237009/recent-trends-in-chemotherapy-use-and-oncologists-treatment-recommendations-for-early-stage-breast-cancer
#9
Allison W Kurian, Irina Bondarenko, Reshma Jagsi, Christopher R Friese, M Chandler McLeod, Sarah T Hawley, Ann S Hamilton, Kevin C Ward, Timothy P Hofer, Steven J Katz
Background: There is growing concern about overtreatment of breast cancer as outcomes have improved over time. However, little is known about how chemotherapy use and oncologists' recommendations have changed in recent years. Methods: We surveyed 5080 women (70% response rate) diagnosed with breast cancer between 2013 and 2015 and accrued through two Surveillance, Epidemiology, and End Results registries (Georgia and Los Angeles) about chemotherapy receipt and their oncologists' chemotherapy recommendations...
December 11, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29214412/gestational-age-at-birth-and-risk-of-intellectual-disability-without-a-common-genetic-cause
#10
Hein Heuvelman, Kathryn Abel, Susanne Wicks, Renee Gardner, Edward Johnstone, Brian Lee, Cecilia Magnusson, Christina Dalman, Dheeraj Rai
Preterm birth is linked to intellectual disability and there is evidence to suggest post-term birth may also incur risk. However, these associations have not yet been investigated in the absence of common genetic causes of intellectual disability, where risk associated with late delivery may be preventable. We therefore aimed to examine risk of intellectual disability without a common genetic cause across the entire range of gestation, using a matched-sibling design to account for unmeasured confounding by shared familial factors...
December 6, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29212571/expression-of-homeobox-gene-hlx-and-its-downstream-target-genes-are-altered-in-placentae-from-discordant-twin-pregnancies
#11
Nicola Yuen, Shaun P Brennecke, Mark P Umstad, Hannah E J Yong, Anthony J Borg, Gayathri Rajaraman, Bill Kalionis, Padma Murthi
A discordant twin gestation, in which one fetus is significantly growth restricted, compared to the other normal twin, is a unique model that can be used to elucidate the mechanism(s) by which the intrauterine environment affects fetal growth. In many model systems, placental transcription factor genes regulate fetal growth. Transcription factors regulate growth through their activation or repression of downstream target genes that mediate important cell functions. The objective of this study was to determine the expression of the placental HLX homeobox gene transcription factor and its downstream target genes in dizygotic twins with growth discordance...
December 7, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29187466/a-comparison-of-the-performance-of-endopredict-clinical-and-nhs-predict-in-120-patients-treated-for-er-positive-breast-cancer
#12
COMPARATIVE STUDY
Kinan Mokbel, Umar Wazir, Hiba El Hage Chehade, Aisling Manson, Christina Choy, Victoria Moye, Kefah Mokbel
BACKGROUND: Computational algorithms, such as NHS PREDICT, have been developed using cancer registry data to guide decisions regarding adjuvant chemotherapy. They are limited by biases of the underlying data. Recent breakthroughs in molecular biology have aided the development of genomic assays which provide superior clinical information. In this study, we compared the performance in risk stratification of EndoPredict Clinical (EPClin, a composite of clinical data and EndoPredict) and PREDICT in a cohort of patients with breast cancer considered potential candidates for chemotherapy by the clinicians...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29184446/birth-weight-sex-and-celiac-disease-a-nationwide-twin-study
#13
Ralf Kuja-Halkola, Benjamin Lebwohl, Jonas Halfvarson, Louise Emilsson, Patrik K Magnusson, Jonas F Ludvigsson
Objective: Earlier research suggests that birth weight may be associated with celiac disease (CD), but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures. Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29182666/gnrh-receptor-gene-mutations-in-adolescents-and-young-adults-presenting-with-signs-of-partial-gonadotropin-deficiency
#14
Johanna Hietamäki, Matti Hero, Elina Holopainen, Johanna Känsäkoski, Kirsi Vaaralahti, Anna-Pauliina Iivonen, Päivi J Miettinen, Taneli Raivio
Biallelic, partial loss-of-function mutations in GNRHR cause a wide spectrum of reproductive phenotypes from constitutional delay of growth and puberty to complete congenital hypogonadotropic hypogonadism. We studied the frequency of GNRHR, FGFR1, TAC3, and TACR3 mutations in nine adolescent and young adult females with clinical cues consistent with partial gonadotropin deficiency (stalled puberty, unexplained secondary amenorrhea), and describe phenotypic features and molecular genetic findings of monozygotic twin brothers with stalled puberty...
2017: PloS One
https://www.readbyqxmd.com/read/29172821/risk-of-donor-demise-after-laser-therapy-for-twin-twin-transfusion-when-complicated-by-growth-discordance-and-abnormal-umbilical-artery-doppler-findings
#15
Matthew M Finneran, Megan A Templin, Courtney D Stephenson
OBJECTIVE: To investigate the natural course of abnormal umbilical artery Doppler (UAD) findings in donor fetuses after laser surgery and the prognostic significance of resolution, persistence, or new onset UAD abnormalities with and without the presence of preoperative growth discordance. STUDY DESIGN: Retrospective cohort study of all monochorionic-diamniotic multi-fetal gestations diagnosed with twin-twin transfusion syndrome (TTTS) undergoing laser surgery at a single large metropolitan referral center from 2010-2016...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29169184/her2-expression-patterns-in-paired-primary-and-metastatic-endometrial-cancer-lesions
#16
Mari Kyllesø Halle, Ingvild Løberg Tangen, Hege Fredriksen Berg, Erling Andre Hoivik, Karen K Mauland, Kanthida Kusonmano, Anna Berg, Antoni Hurtado, Karl Henning Kalland, Anne M Øyan, Ingunn Stefansson, Olav K Vintermyr, Henrica M Werner, Ingfrid S Haldorsen, Jone Trovik, Helga B Salvesen, Camilla Krakstad
BACKGROUND: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers has been less studied, including endometrial cancer. We investigated expression levels of HER2 (ERBB2) in a large cohort of endometrial cancer lesions, also including complex atypical hyperplasia and metastatic lesions. METHODS: 67 precursor lesions, 790 primary endometrial cancers and 383 metastatic lesions were investigated for HER2 expression in relation to clinicopathologic features and outcome...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29155475/weight-discordance-and-perinatal-mortality-in-twin-pregnancies-a-systematic-review-and-meta-analysis
#17
REVIEW
Francesco D'Antonio, Anthony O Odibo, Federico Prefumo, Asma Khalil, Danilo Buca, Maria Elena Flacco, Marco Liberati, Lamberto Manzoli, Ganesh Acharya
OBJECTIVES: The primary aim of this systematic review was to explore the strength of association between birthweight (BW) discordance and perinatal mortality in twin pregnancies; the secondary aim was to ascertain the contribution of gestational age and growth restriction in determining mortality in growth discordant twins. METHODS: Medline, Embase, Cinahl and Clinicaltrials.gov databases were searched. Only studies reporting the risk of mortality in twin pregnancies affected compared to those not affected by weight discordance were included...
November 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29150249/accuracy-of-the-cobas-egfr-mutation-assay-in-non-small-cell-lung-cancer-compared-with-three-laboratory-developed-tests
#18
Haruhiko Nakamura, Hirotaka Koizumi, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Hideki Marushima, Hisashi Saji, Masayuki Takagi
BACKGROUND: The reliability of the cobas EGFR assay to detect epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) as an in vitro diagnostic test was compared with 3 laboratory-developed tests (LDTs). MATERIALS AND METHODS: After screening for EGFR mutations using formalin-fixed-paraffin-embedded NSCLC tissue sections using the cobas EGFR assay, 151 samples were further tested with 3 LDTs; the peptide nucleic acid-locked nucleic acid polymerase chain reaction (PCR) clamp, PCR invader, and Cycleave assays...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29133522/systolic-blood-pressure-response-in-sprint-systolic-blood-pressure-intervention-trial-and-accord-action-to-control-cardiovascular-risk-in-diabetes-a-possible-explanation-for-discordant-trial-results
#19
Chenxi Huang, Sanket S Dhruva, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Khurram Nasir, Harlan M Krumholz
BACKGROUND: SPRINT (Systolic Blood Pressure Intervention Trial) and the ACCORD (Action to Control Cardiovascular Risk in Diabetes) blood pressure trial used similar interventions but produced discordant results. We investigated whether differences in systolic blood pressure (SBP) response contributed to the discordant trial results. METHODS AND RESULTS: We evaluated the distributions of SBP response during the first year for the intensive and standard treatment groups of SPRINT and ACCORD using growth mixture models...
November 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29120532/sexual-orientation-concordance-and-un-happiness-about-births
#20
Caroline Sten Hartnett, Lisa Lindley, Katrina M Walsemann, Daniela V Negraia
CONTEXT: A woman's happiness about a pregnancy and birth has implications for her child's health and her own well-being. Sexual orientation and, particularly, the extent of concordance across its dimensions (sexual identity, behavior and attraction) may be related to happiness about these events, but research on this relationship has been lacking. METHODS: Data on 5,744 pregnancies ending in births among women aged 15-44 in three waves of the National Survey of Family Growth (2006-2015) were examined...
November 9, 2017: Perspectives on Sexual and Reproductive Health
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