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Growth discordance

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https://www.readbyqxmd.com/read/27885296/outcome-of-twin-deliveries-at-a-tertiary-care-centre-of-eastern-nepal
#1
S Chaudhary, R R Singh, G S Shah, J Agrawal, S Kafle, L Shah
BACKGROUND: Twins, compared to singletons, have higher perinatal mortality and morbidity. The aim of this study was to describe the twinning rate, epidemiological variables and hospital outcome of twin deliveries and to find out ways of better management of twins in our part. METHODS: A retrospective evaluation of the outcome of 92 twin pregnancies during one year study period (1st January 2014 to 31st December 2014) was conducted at BPKIHS. Twins delivered within the institution were included but cases less than 28 weeks gestation were excluded...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27862520/medullary-bone-in-fossils-function-evolution-and-significance-in-growth-curve-reconstructions-of-extinct-vertebrates
#2
Edina Prondvai
Medullary bone (MB) is a special endosteal tissue forming in the bones of female birds during egg-laying to serve as a labile calcium reservoir for building the hard eggshell. Therefore, the presence of MB reported in multiple non-avian dinosaurs is currently considered as evidence that those specimens were sexually mature females in their reproductive period. This interpretation has led to further inferences on species-specific growth strategies and related life history aspects of these extinct vertebrates...
November 18, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27859836/outcome-in-monochorionic-twin-pregnancies-with-selective-intrauterine-growth-restriction-according-to-the-umbilical-artery-doppler-pattern-of-the-smaller-twin-a-systematic-review-and-meta-analysis
#3
REVIEW
Danilo Buca, Giorgio Pagani, Giuseppe Rizzo, Alessandra Familiari, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Francesco Fanfani, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of monochorionic (MC) twin pregnancies affected by selective intra-uterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin. METHODS: Medline, Embase, Cinhal and ClinicalTrials.gov databases (2000-2016) were searched. sIUGR was defined as the presence of one twin with estimated fetal weight and/or abdominal circumference less than 10(th) or 5(th) percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (type I: persistently positive, type II: persistently absent/reversed, type III: intermittently absent/reversed)...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27854393/birth-weight-in-live-births-and-stillbirths
#4
L C Y Poon, M Y Tan, G Yerlikaya, A Syngelaki, K H Nicolaides
OBJECTIVE: To establish a normal range of birth weights for gestational age at delivery and to compare the proportion of live births and stillbirths that are classified as small-for-gestational age (SGA) according to our normal range vs that of the INTERGROWTH-21(st) standard. METHODS: The study population comprised 113 019 live births and 437 (0.4%) stillbirths. The inclusion criterion for establishing a normal range of birth weights for gestational age was the live birth of a phenotypically normal neonate ≥ 24 weeks' gestation and the exclusion criteria were smoking and prepregnancy hypertension, diabetes mellitus, systemic lupus erythematosus or antiphospholipid syndrome, pre-eclampsia, gestational hypertension, gestational diabetes mellitus or iatrogenic preterm birth for fetal growth restriction in the current pregnancy...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27848393/comparison-of-rat-and-rabbit-embryo-fetal-developmental-toxicity-data-for-379-pharmaceuticals-on-the-nature-and-severity-of-developmental-effects
#5
Peter T Theunissen, Sonja Beken, Bruce K Beyer, William J Breslin, Gregg D Cappon, Connie L Chen, Gary Chmielewski, Luc De Schaepdrijver, Brian Enright, Jennifer E Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M Hoberman, Julia Y Hui, Thomas B Knudsen, Susan B Laffan, Susan L Makris, Matt Martin, Mary Ellen McNerney, Christine L Siezen, Dinesh J Stanislaus, Jane Stewart, Kary E Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F Weinbauer, Sandra Wood, Aldert H Piersma
Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT testing could be limited to one species, or whether the testing in a second species could be decided on a case-by-case basis. As part of a consortium initiative, we built and queried a database of 379 compounds with EFDT studies (in both rat and rabbit animal models) conducted for marketed and non-marketed pharmaceuticals for their potential for adverse developmental and maternal outcomes, including EFDT incidence and the nature and severity of adverse findings...
November 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27847254/vascular-calcification-in-ckd-mbd-roles-for-phosphate-fgf23-and-klotho
#6
REVIEW
Shunsuke Yamada, Cecilia M Giachelli
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD population. Complex pathological mechanisms are involved in the development of VC, including osteochondrogenic differentiation and apoptosis of vascular smooth muscle cells, instability and release of extracellular vesicles loaded calcium and phosphate, and elastin degradation. Elevated serum phosphate is a late manifestation of CKD, and has been shown to accelerate mineral deposition in both the vessel wall and heart valves...
November 12, 2016: Bone
https://www.readbyqxmd.com/read/27780543/discordance-of-cord-insertions-as-a-predictor-of-discordant-fetal-growth-in-monochorionic-twins
#7
Olivia Cambiaso, De-Peng Zhao, Jose I Abasolo, Horacio A Aiello, Dick Oepkes, Enrico Lopriore, Lucas Otaño
INTRODUCTION: The type of cord insertion within monochorionic twin pairs could be different. The purpose of study is to evaluate the association of different combinations of placental umbilical cord insertions with birth weight discordance in a large cohort of monochorionic twins. METHODS: All consecutive monochorionic placentas from either uncomplicated twin pregnancies or with fetal weight discordance examined and injected with color dye at our centers were included in this study (n = 374)...
November 2016: Placenta
https://www.readbyqxmd.com/read/27773498/comparative-pharmacodynamics-of-four-different-carbapenems-in-combination-with-polymyxin-b-against-carbapenem-resistant-acinetobacter-baumannii
#8
Justin R Lenhard, Jonathan S Gall, Jurgen B Bulitta, Visanu Thamlikitkul, Cornelia B Landersdorfer, Alan Forrest, Roger L Nation, Jian Li, Brian T Tsuji
The objective of this study was to determine the comparative pharmacodynamics of four different carbapenems in combination with polymyxin B (PMB) against carbapenem-resistant Acinetobacter baumannii isolates using time-kill experiments at two different inocula. Two A. baumannii strains (03-149-1 and N16870) with carbapenem minimum inhibitory concentrations (MICs) ranging from 8 to 64 mg/L were investigated in 48-h time-kill experiments using starting inocula of 10(6) CFU/mL and 10(8) CFU/mL. Concentration arrays of ertapenem, doripenem, meropenem and imipenem at 0...
September 20, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27766549/daily-life-reflections-of-acromegaly-guidelines
#9
T Apaydin, H M Ozkaya, F E Keskin, O A Haliloglu, K Karababa, S Erdem, P Kadioglu
PURPOSE: To determine the differences in acromegaly diagnosis, treatment, and follow-up among Turkish endocrinologists, and to investigate how the published guidelines are applied in clinical practice. METHODS: The questionnaire was formatted as an electronic survey, conducted between November and December 2015, and sent weekly for 6 weeks via e-mail to 528 endocrinologists in Turkey. RESULTS: The questionnaire was answered by 37.4 % of endocrinologists...
October 20, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27764697/prognostic-impact-of-her2-and-er-status-of-circulating-tumor-cells-in-metastatic-breast-cancer-patients-with-a-her2-negative-primary-tumor
#10
Nick Beije, Wendy Onstenk, Jaco Kraan, Anieta M Sieuwerts, Paul Hamberg, Luc Y Dirix, Anja Brouwer, Felix E de Jongh, Agnes Jager, Caroline M Seynaeve, Ngoc M Van, John A Foekens, John W M Martens, Stefan Sleijfer
BACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor receptor 2 (HER2) overexpression yields resistance to endocrine therapies. Here the prevalence and prognostic impact of HER2-positive circulating tumor cells (CTCs) were investigated retrospectively in metastatic breast cancer (MBC) patients with a HER2-negative primary tumor receiving endocrine therapy. Additionally, the prevalence and prognostic significance of HER2-positive CTCs were explored in a chemotherapy cohort, as well as the prognostic impact of the estrogen receptor (ER) CTC status in both cohorts...
October 17, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27734505/amniotic-fluid-discordance-in-monochorionic-diamniotic-twin-pregnancies-is-associated-with-increased-risk-for-twin-anemia-polycythemia-sequence
#11
Liran Hiersch, Mayan Eitan, Eran Ashwal, Boaz Weisz, Benny Chayen, Shlomo Lipitz, Yoav Yinon
OBJECTIVE: To estimate the risk for twin anemia-polycythemia sequence (TAPS) and adverse perinatal outcome in monochorionic diamniotic (MCDA) twin pregnancies with amniotic fluid discordance (AFD). METHODS: Retrospective cohort study of 34 MCDA pregnancies with AFD (intertwin difference of ≥3 cm in maximal vertical pocket measurement) without meeting the criteria for twin to twin transfusion syndrome (TTTS) or selective intrauterine growth restriction (sIUGR)...
October 12, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27721876/patients-with-concordant-triple-negative-phenotype-between-primary-breast-cancers-and-corresponding-metastases-have-poor-prognosis
#12
Hee-Chul Shin, Wonshik Han, Hyeong-Gon Moon, In-Ae Park, Dong-Young Noh
PURPOSE: We investigated the prognostic impact of discordance between the receptor status of primary breast cancers and corresponding metastases. METHODS: A total 144 patients with breast cancer and distant metastasis were investigated. The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of primary tumor and corresponding metastases were assessed. Tumor phenotype according to receptor status was classified as triple-negative phenotype (TNP) or non-TNP...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27704008/clinical-impact-on-tuberculosis-treatment-outcomes-of-discordance-between-molecular-and-growth-based-assays-for-rifampin-resistance-california-2003-2013
#13
Neha S Shah, S Y Grace Lin, Pennan M Barry, Yi-Ning Cheng, Gisela Schecter, Ed Desmond
Background.  Data from international settings suggest that isolates of Mycobacterium tuberculosis with rpoB mutations testing phenotypically susceptible to rifampin (RIF) may have clinical significance. We analyzed treatment outcomes of California patients with discordant molecular-phenotypic RIF results. Methods.  We included tuberculosis (TB) patients, during 2003-2013, whose specimens tested RIF susceptible phenotypically but had a rpoB mutation determined by pyrosequencing. Demographic data were abstracted from the California TB registry...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27697943/minimal-intervention-delivered-by-2-1-1-information-and-referral-specialists-promotes-smoke-free-homes-among-2-1-1-callers-a-texas-generalisation-trial
#14
Patricia Dolan Mullen, Lara S Savas, Łucja T Bundy, Regine Haardörfer, Mel Hovell, Maria E Fernández, Jo Ann A Monroy, Rebecca S Williams, Matthew W Kreuter, David Jobe, Michelle C Kegler
BACKGROUND: Replication of intervention research is reported infrequently, limiting what we know about external validity and generalisability. The Smoke Free Homes Program, a minimal intervention, increased home smoking bans by United Way 2-1-1 callers in randomised controlled trials in Atlanta, Georgia and North Carolina. OBJECTIVE: Test the programme's generalisability-external validity in a different context. METHODS: A randomised controlled trial (n=508) of English-speaking callers from smoking-discordant households (≥1 smoker and ≥1 non-smoker)...
October 2016: Tobacco Control
https://www.readbyqxmd.com/read/27695229/ki-67-immunostaining-in-astrocytomas-association-with-histopathological-grade-a-south-indian-study
#15
Nandish Vastrad Shivaprasad, Suchitha Satish, Sunila Ravishankar, Manjunath Gubbi Vimalambike
BACKGROUND: Astrocytomas are the most common primary tumor of the central nervous system. The distinction between different tumor grades can be tested despite criteria given by the World Health Organization (WHO). Ki-67 is a potent biological marker used in grading of astrocytomas, which estimates growth of the neoplasm quantitatively and will help in predicting prognosis accurately. OBJECTIVES: The aim of this was to study the proliferative activity using Ki-67 immunostaining and to assess the relationship of Ki-67 staining with the histopathological grading of astrocytomas...
October 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27687626/a-study-of-tumor-heterogeneity-in-a-case-with-breast-cancer
#16
Haruka Nakada, Hiroshi Nakagomi, Yosuke Hirotsu, Kenji Amemiya, Hitoshi Mochizuki, Masayuki Inoue, Toshio Oyama, Masao Omata
Tumor heterogeneity has been suggested based on clinical and pathological findings. Several clinical findings can be explained by tumor evolution during progression and metastasis. We herein report a case of metastatic breast cancer indicated tumor heterogeneity by clinical findings and a genomic analysis. A 64-year-old woman with advanced breast cancer was treated with primary chemotherapy, to which primary tumor responded. After a 6 month treatment pause, lung, liver, and skin metastases developed and her serum tumor markers were elevated...
September 29, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27685950/comparison-of-epidermal-growth-factor-receptor-mutations-between-metastatic-lymph-node-diagnosed-by-ebus-tbna-and-primary-tumor-in-non-small-cell-lung-cancer
#17
Hyo Jae Kang, Bin Hwangbo, Jin Soo Lee, Moon Soo Kim, Jong Mog Lee, Geon-Kook Lee
INTRODUCTION: Although the use of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is increasing for epidermal growth factor receptor (EGFR) testing in lung cancer, the discordance rate in EGFR mutations between lymph node (LN) samples obtained by EBUS-TBNA and primary tumor (PT) is not well known. Thus, we compared the EGFR mutation status of LN samples obtained by EBUS-TBNA and PTs to estimate the efficacy of using EBUS-TBNA specimens for EGFR testing in advanced, non-squamous, non-small cell lung cancer (NSCLC)...
2016: PloS One
https://www.readbyqxmd.com/read/27685259/multi-center-evaluation-of-the-fully-automated-pcr-based-idylla%C3%A2-kras-mutation-assay-for-rapid-kras-mutation-status-determination-on-formalin-fixed-paraffin-embedded-tissue-of-human-colorectal-cancer
#18
Jérôme Solassol, Julie Vendrell, Bruno Märkl, Christian Haas, Beatriz Bellosillo, Clara Montagut, Matthew Smith, Brendan O'Sullivan, Nicky D'Haene, Marie Le Mercier, Morten Grauslund, Linea Cecilie Melchior, Emma Burt, Finbarr Cotter, Daniel Stieber, Fernando de Lander Schmitt, Valentina Motta, Calogero Lauricella, Richard Colling, Elizabeth Soilleux, Matteo Fassan, Claudia Mescoli, Christine Collin, Jean-Christophe Pagès, Peter Sillekens
Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal cancer are KRAS exon 2 mutations (40% prevalence); lower prevalence is observed for KRAS exon 3 and 4 mutations (6%) and NRAS exon 2, 3, and 4 mutations (5%). The Idylla™ KRAS Mutation Test on the molecular diagnostics Idylla™ platform is a simple (<2 minutes hands-on time), highly reliable, and rapid (approximately 2 hours turnaround time) in vitro diagnostic sample-to-result solution...
2016: PloS One
https://www.readbyqxmd.com/read/27647340/ep20-06-growth-discordance-of-monoamniotic-twin-due-to-difference-of-cord-diameter-in-forked-umbilical-cord-a-case-report
#19
Y Sun
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27634948/seeksv-an-accurate-tool-for-somatic-structural-variation-and-virus-integration-detection
#20
Ying Liang, Kunlong Qiu, Bo Liao, Wen Zhu, Xuanlin Huang, Lin Li, Xiangtao Chen, Keqin Li
MOTIVATION: Many forms of variations exist in the human genome including single nucleotide polymorphism, small insert/deletion (DEL) (indel) and structural variation (SV). Somatically acquired SV may regulate the expression of tumor-related genes and result in cell proliferation and uncontrolled growth, eventually inducing tumor formation. Virus integration with host genome sequence is a type of SV that causes the related gene instability and normal cells to transform into tumor cells...
September 14, 2016: Bioinformatics
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