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Growth discordance

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https://www.readbyqxmd.com/read/29763896/evaluation-of-the-her2-and-hormone-receptor-status-in-metastatic-breast-cancer-using-cell-blocks-a-multi-institutional-study
#1
Rieko Nishimura, Yuya Murata, Kiyoshi Mori, Katsushige Yamashiro, Kazuya Kuraoka, Shu Ichihara, Kenichi Taguchi, Hiroyoshi Suzuki, Masahiro Ito, Natsumi Yamashita
OBJECTIVE: We explore the problems associated with the cell block (CB) method for receptor analysis in breast cancer metastases and propose a method for reporting the results. STUDY DESIGN: Nine institutions used the CB method for the analysis of hormone receptors (HRs) and HER2 (human epidermal growth factor receptor 2) protein in cytological specimens of breast cancer metastases in routine practice. The stained slides were independently evaluated by 8 pathologists...
May 15, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29763608/early-prognostic-factors-of-outcomes-in-monochorionic-twin-pregnancy-systematic-review-and-meta-analysis
#2
REVIEW
Fiona L Mackie, Matthew J Hall, R Katie Morris, Mark D Kilby
OBJECTIVE: Assess ability of first trimester pregnancy related factors (ultrasound measurements, maternal characteristics, biomarkers) to predict complications in monochorionic twin pregnancies DATA SOURCES: MEDLINE, EMBASE, ISI Web of Science, CINAHL, the Cochrane Central Registration of Controlled Trials and Research Registers, and Google Scholar, from inception to 12 May 2017. Grey literature and bibliographies of articles were checked. STUDY ELIGIBILITY CRITERIA: Studies that reported ultrasound measurements, maternal characteristics, or potential biomarkers, measured in the first trimester in monochorionic diamniotic twin pregnancies, where the potential prognostic ability between the variable and twin-twin transfusion syndrome, growth restriction, or intrauterine fetal death could be assessed...
May 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29744813/assessment-of-the-methods-used-to-detect-her2-positive-advanced-extramammary-paget-s-disease
#3
Ikuko Hirai, Keiji Tanese, Yoshio Nakamura, Atsushi Otsuka, Yasuhiro Fujisawa, Yuki Yamamoto, Hiroo Hata, Taku Fujimura, Shigeto Matsushita, Koji Yoshino, Kaori Kameyama, Masayuki Amagai, Takeru Funakoshi
The human epidermal growth factor receptor 2 (HER2) is recognized as an oncogene as well as a therapeutic target in various cancers. Certain patients with advanced extramammary Paget's disease (EMPD) have also been reported to express HER2, which is therefore considered a therapeutic target for EMPD. However, an accurate methodology to determine HER2-positive EMPD has not been established. To assess the optimal methods for detection of HER2-positive EMPD, 73 EMPD samples were analyzed by immunohistochemical (IHC) staining, fluorescence in situ hybridization (FISH), and the HER2 testing algorithm for breast cancer of the American Society of Clinical Oncology/College of American Pathologists, which combined the results of IHC staining and FISH...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29735606/allele-specific-control-of-replication-timing-and-genome-organization-during-development
#4
Juan Carlos Rivera-Mulia, Andrew Dimond, Daniel Vera, Claudia Trevilla-Garcia, Takayo Sasaki, Jared Zimmerman, Catherine Dupont, Joost Gribnau, Peter Fraser, David M Gilbert
DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional activity and 3D genome organization. Here, we derived distinct cell types from F1 hybrid musculus X castaneus mouse crosses and exploited the high single nucleotide polymorphism (SNP) density to characterize allelic differences in RT (Repli-seq), genome organization (Hi-C and promoter-capture Hi-C), gene expression (total nuclear RNA-seq) and chromatin accessibility (ATAC-seq)...
May 7, 2018: Genome Research
https://www.readbyqxmd.com/read/29722058/breast-cancer-intra-tumour-heterogeneity-current-status-and-clinical-implications
#5
REVIEW
Chitra Joseph, Athanasia Papadaki, Maryam Althobiti, Mansour Alsaleem, Mohammed A Aleskandarany, Emad A Rakha
Breast cancer (BC) is a heterogeneous disease that varies in presentation, morphological features, behaviour and response to therapy. High throughput molecular profiling studies have revolutionised our understanding of BC heterogeneity and demonstrated that molecular portraits of tumours are not only variable between tumours but also within individual tumours. Current evidence indicates that spatial and temporal intra-tumour heterogeneity of BC exists at levels beyond common anticipations. Intra-tumoural heterogeneity poses critical challenges in the diagnosis, prediction of behaviour and management of BC...
May 2, 2018: Histopathology
https://www.readbyqxmd.com/read/29698983/micrornas-in-high-and-low-responders-to-resistance-training-in-breast-cancer-survivors
#6
Amanda D Hagstrom, Joshua Denham
Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention...
April 26, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29675904/risk-factors-for-fetal-death-after-radiofrequency-ablation-for-complicated-monochorionic-twin-pregnancies
#7
Luming Sun, Gang Zou, Yingjun Yang, Fenhe Zhou, Duan Tao
OBJECTIVE: Radiofrequency ablation (RFA) is a management alternative for complicated monochorionic twin pregnancies. The purpose of this study is to evaluate risk factors for fetal death after RFA. METHODS: An observational study was performed to document the perinatal outcomes of all cases undergoing fetal reduction using RFA from 2010 to 2016 at the Shanghai First Maternity and Infant Hospital. A multiple regression model was built to identify predictors of the death of the remaining fetus after RFA...
April 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29620244/egfr-mutations-subset-in-chinese-lung-squamous-cell-carcinoma-patients
#8
Ying Sun, Xin Yin, Miao-Miao Wen, Jiao Zhang, Xue-Jiao Wang, Jing-Hua Xia, Yan-Ning Zhang, Zhi-Pei Zhang, Xiao-Fei Li
Research has identified that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) possess large benefits for adenocarcinoma (ADC), although little benefit for squamous cell carcinoma (SCC). The aim of the present study was to investigate the percentage of patients with SCC with the EGFR mutations subset and the benefits of EGFR TKIs in SCC. In the present study, the EGFR mutations subset was detected with an amplification refractory mutation system in 1,359 clinical SCC tissues. The association of the EGFR mutations subset with clinicopathological parameters was evaluated using the Mann‑Whitney U test, and Kruskal‑Wallis H...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29590717/a-retrospective-study-of-discordant-twin-growth-in-dichorionic-twin-pregnancies-and-risk-of-preterm-delivery-at-split-university-hospital-centre-three-year-experience
#9
Marko Vulić, Lara Lalić, Luka Vulić, Damir Roje, Zdeslav Benzon, Zoran Meštrović
The aim was to determine whether discordant twin growth has an impact on preterm birth in dichorionic pregnancies. This retrospective study included dichorionic twin pregnancies in the period from January 1, 2013 to December 31, 2015. The following variables were investigated: maternal age (years), parity, body mass index (kg/m2), week (≤366/7 and ≥37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and Apgar score (≤7, 8-10). Discordant twin growth in dichorionic pregnancies was found to be associated with preterm birth (χ2=4...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29574422/maternal-variants-in-nlrp-and-other-maternal-effect-proteins-are-associated-with-multilocus-imprinting-disturbance-in-offspring
#10
Matthias Begemann, Faisal I Rezwan, Jasmin Beygo, Louise E Docherty, Julia Kolarova, Christopher Schroeder, Karin Buiting, Kamal Chokkalingam, Franziska Degenhardt, Emma L Wakeling, Stephanie Kleinle, Daniela González Fassrainer, Barbara Oehl-Jaschkowitz, Claire L S Turner, Michal Patalan, Maria Gizewska, Gerhard Binder, Can Thi Bich Ngoc, Vu Chi Dung, Sarju G Mehta, Gareth Baynam, Julian P Hamilton-Shield, Sara Aljareh, Oluwakemi Lokulo-Sodipe, Rachel Horton, Reiner Siebert, Miriam Elbracht, Isabel Karen Temple, Thomas Eggermann, Deborah J G Mackay
BACKGROUND: Genomic imprinting results from the resistance of germline epigenetic marks to reprogramming in the early embryo for a small number of mammalian genes. Genetic, epigenetic or environmental insults that prevent imprints from evading reprogramming may result in imprinting disorders, which impact growth, development, behaviour and metabolism. We aimed to identify genetic defects causing imprinting disorders by whole-exome sequencing in families with one or more members affected by multilocus imprinting disturbance...
March 24, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29562902/effective-osimertinib-treatment-in-a-patient-with-discordant-t790-m-mutation-detection-between-liquid-biopsy-and-tissue-biopsy
#11
Isa Mambetsariev, Lalit Vora, Kim Wai Yu, Ravi Salgia
BACKGROUND: We report the successful treatment of the patient with osimertinib 80 mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGFR) T790 M between liquid biopsy and tissue biopsy methods. CASE PRESENTATION: A 57-year-old Hispanic male patient initially diagnosed with an EGFR 19 deletion positive lung adenocarcinoma and clinically responded to initial erlotinib treatment...
March 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29558499/metrics-of-early-childhood-growth-in-recent-epidemiological-research-a-scoping-review
#12
Michael Leung, Nandita Perumal, Elnathan Mesfin, Aditi Krishna, Seungmi Yang, William Johnson, Diego G Bassani, Daniel E Roth
Metrics to quantify child growth vary across studies of the developmental origins of health and disease. We conducted a scoping review of child growth studies in which length/height, weight or body mass index (BMI) was measured at ≥ 2 time points. From a 10% random sample of eligible studies published between Jan 2010-Jun 2016, and all eligible studies from Oct 2015-June 2016, we classified growth metrics based on author-assigned labels (e.g., 'weight gain') and a 'content signature', a numeric code that summarized the metric's conceptual and statistical properties...
2018: PloS One
https://www.readbyqxmd.com/read/29523586/little-and-large-the-effects-of-twin-growth-discordance
#13
EDITORIAL
Cecilie Halling, John David Corcoran
No abstract text is available yet for this article.
March 9, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29522548/yeast-based-assays-for-characterization-of-the-functional-effects-of-single-nucleotide-polymorphisms-in-human-dna-repair-genes
#14
Changshin Kim, Jinmo Yang, Su-Hyun Jeong, Hayoung Kim, Geun-Hee Park, Hwa Beom Shin, MyungJa Ro, Kyoung-Yeon Kim, YoungJoon Park, Keun Pil Kim, KyuBum Kwack
DNA repair mechanisms maintain genomic integrity upon exposure to various types of DNA damage, which cause either single- or double-strand breaks in the DNA. Here, we propose a strategy for the functional study of single nucleotide polymorphisms (SNPs) in the human DNA repair genes XPD/ERCC2, RAD18, and KU70/XRCC6 and the checkpoint activation gene ATR that are essentially involved in the cell cycle and DNA damage repair. We analyzed the mutational effects of the DNA repair genes under DNA-damaging conditions, including ultraviolet irradiation and treatment with genotoxic reagents, using a Saccharomyces cerevisiae system to overcome the limitations of the human cell-based assay...
2018: PloS One
https://www.readbyqxmd.com/read/29516637/unique-mechanisms-of-connective-tissue-growth-factor-regulation-in-airway-smooth-muscle-in-asthma-relationship-with-airway-remodelling
#15
Junfei Wang, Alen Faiz, Qi Ge, Cornelis J Vermeulen, Joanne Van der Velden, Kenneth J Snibson, Rob van de Velde, Sonia Sawant, Dikaia Xenaki, Brian Oliver, Wim Timens, Nick Ten Hacken, Maarten van den Berge, Alan James, John G Elliot, Liang Dong, Janette K Burgess, Anthony W Ashton
Neovascularization, increased basal membrane thickness and increased airway smooth muscle (ASM) bulk are hallmarks of airway remodelling in asthma. In this study, we examined connective tissue growth factor (CTGF) dysregulation in human lung tissue and animal models of allergic airway disease. Immunohistochemistry revealed that ASM cells from patients with severe asthma (A) exhibited high expression of CTGF, compared to mild and non-asthmatic (NA) tissues. This finding was replicated in a sheep model of allergic airways disease...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29514724/oestrogen-progesterone-and-stem-cells-the-discordant-trio-in-endometriosis
#16
Chithra Janardhanan Susheelamma, Sathy M Pillai, Sivakumari Asha Nair
Oestrogen-progesterone signalling is highly versatile and critical for the maintenance of healthy endometrium in humans. The genomic and nongenomic signalling cascades initiated by these hormones in differentiated cells of endometrium have been the primary focus of research since 1920s. However, last decade of research has shown a significant role of stem cells in the maintenance of a healthy endometrium and the modulatory effects of hormones on these cells. Endometriosis, the growth of endometrium outside the uterus, is very common in infertile patients and the elusiveness in understanding of disease pathology causes hindrance in selection of treatment approaches to enhance fertility...
March 8, 2018: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/29500316/cognitive-outcome-in-childhood-of-birth-weight-discordant-monochorionic-twins-the-long-term-effects-of-fetal-growth-restriction
#17
Ravi Shankar Swamy, Helen McConachie, Jane Ng, Judith Rankin, Murthy Korada, Stephen Sturgiss, Nicholas D Embleton
AIM: Intrauterine growth restriction (IUGR) is associated with poorer outcomes in later life. We used a monochorionic twin model with IUGR in one twin to determine its impact on growth and neurocognitive outcomes. METHODS: Monochorionic twins with ≥20% birth weight discordance born in the north of England were eligible. Cognitive function was assessed using the British Ability Scales. The Strength and Difficulties Questionnaire was used to identify behavioural problems...
March 2, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29498449/her2-equivocal-breast-cancer-that-is-positive-by-alternative-probe-her2-fish-are-classified-as-her2-negative-by-oncotype-dx
#18
Gary H Tozbikian, Debra L Zynger
In breast cancer, human epidermal growth factor receptor 2 (HER2) status is determined by immunohistochemistry (IHC) and/or in situ hybridization. Oncotype DX also reports HER2 status by an rt-PCR-based assay. Assay concordance between IHC and fluorescent in situ hybridization (FISH) (including alternative probe HER2 FISH) vs Oncotype DX HER2 rt-PCR has not been described in the post-2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) HER2 Guideline revision setting. We performed a retrospective review of HER2 equivocal invasive breast carcinoma from 2014 to 2016 with the Oncotype DX HER2 result...
March 2, 2018: Breast Journal
https://www.readbyqxmd.com/read/29492955/an-approximate-joint-model-for-multiple-paired-longitudinal-outcomes-and-time-to-event-data
#19
Angelo F Elmi, Katherine L Grantz, Paul S Albert
Joint modeling of multivariate paired longitudinal data and time-to-event data presents computational challenges that supersede full likelihood estimation due to the large dimensional random effects vector needed to capture correlation due to clustering with respect to pairs, subjects, and outcomes. We propose an alternative, computationally simpler approach to estimation of complex shared parameter models where missing data is imputed based on the Posterior Predictive Distribution from a Conditional Linear Model (CLM) approximation...
February 28, 2018: Biometrics
https://www.readbyqxmd.com/read/29487256/pyrosequencing-to-resolve-discrepant-xpert-mtb-rif-and-mycobacterial-growth-indicator-tube-960
#20
Kanchan Ajbani, Mubin Kazi, Jeffrey Tornheim, Swapna Naik, Rajeev Soman, Anjali Shetty, Camilla Rodrigues
Delayed diagnosis of drug resistance has been a major obstacle to proper management and control of drug-resistant tuberculosis (TB). Expanded access to rapid molecular diagnostics such as Xpert MTB/RIF has been helpful, but has generated confusion about how to interpret genotype-phenotype discordance. Optimal management is not clearly defined for patients with rifampin resistance by Xpert MTB/RIF but rifampin susceptibility by phenotypic testing. To resolve this discrepancy, we performed pyrosequencing of discordant isolates identified at a reference laboratory over a 6-month period...
March 2018: Lung India: Official Organ of Indian Chest Society
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