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https://www.readbyqxmd.com/read/28454406/carcinoid-syndrome-from-a-carcinoid-tumor-of-the-pancreas-without-liver-metastases-a-case-report-and-literature-review
#1
Nikolaos Zavras, Demetrios Schizas, Nikolaos Machairas, Vasileia Damaskou, Nikolaos Economopoulos, Anastasios Machairas
A carcinoid tumor of the pancreas (CTP) is a rare pancreatic neoplasm, and usually presents with carcinoid syndrome (CS). CS consists of the classic symptom triad of cutaneous flushing, diarrhea and valvular disease, and occurs in the majority of patients with liver metastases. In the present study, the patient presented with symptoms of CS. A diagnosis of CTP with CS was suspected due to high levels of urine 5-hydroxyindolacetic acid, and this was confirmed by a fine-needle aspiration biopsy. Computed tomography showed extended lymphadenopathy, but no liver metastases...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454366/gene-signatures-associated-with-drug-resistance-to-irinotecan-and-oxaliplatin-predict-a-poor-prognosis-in-patients-with-colorectal-cancer
#2
Xinrong Sun, Xiang Wang, Wenming Feng, Huihui Guo, Chengwu Tang, Yongliang Lu, Xiaobin Xiang, Ying Bao
The identification of novel survival predictors may help to improve the appropriate management of colorectal cancer (CRC). In the present study, two gene sets associated with irinotecan or oxaliplatin resistance in CRC cell lines were first identified and subsequently applied to the clinical CRC microarray dataset GSE14333. Subsequently, a 60-gene irinotecan resistance-associated signature and a 13-gene oxaliplatin resistance-associated signature were established, which were able to classify CRC patients into high- and low-risk subgroups with varied clinical outcomes [irinotecan-resistance gene signature: hazard ratio (HR)=0...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454358/prognostic-relevance-of-dna-flow-cytometry-in-breast-cancer-revisited-the-25-year-experience-of-the-portuguese-institute-of-oncology-of-lisbon
#3
António E Pinto, Teresa Pereira, Giovani L Silva, Saudade André
The potential prognostic significance of DNA flow cytometric measurements (DNA ploidy and S-phase fraction) in breast cancer remains in dispute. Inconclusive data, primarily due to the lack of consistent standardization and quality control programs, have limited its translation into clinical practice. The aim of the present review, based on the 25-year experience of the Portuguese Institute of Oncology of Lisbon, is to assess the clinical relevance and application of DNA flow cytometry for the prognosis of breast cancer...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454296/association-between-braf-v600e-mutation-and-the-clinicopathological-features-of-solitary-papillary-thyroid-microcarcinoma
#4
Hai-Zhen Lu, Tian Qiu, Jian-Ming Ying, Ning Lyn
The B-Raf proto-oncogene serine/threonine kinase (BRAF)(V600E) mutation is an important oncogene in the development of papillary thyroid carcinoma (PTC) and has been identified as a risk factor for poor prognosis in patients with PTC. However, whether the BRAF(V600E) mutation is a prognostic marker in patients with solitary papillary thyroid microcarcinoma (sPTMC) has not yet been established. The present study aimed to identify the association between BRAF(V600E) mutation and the clinicopathological features of patients with sPTMC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454285/stereotactic-radiosurgery-for-brain-metastasis-from-gynecological-malignancies
#5
Ekkehard Kasper, Franziska Ippen, Eric Wong, Eric Uhlmann, Scott Floyd, Anand Mahadevan
Brain metastases are relatively uncommon in gynecological malignancies, and there is limited available data on their management. The present study reports the outcomes of patients with brain metastasis from gynecological malignancies who were treated with stereotactic radiosurgery (SRS). Patients with brain metastasis from a gynecological primary site were treated with SRS using the Cyberknife™ frameless SRS system. Primary lesions were treated with a single fraction of 16-22 Gy. A total of 3 resection cavities were treated with 8 Gy 3 times, meaning a total of 24 Gy, and 1 recurrent lesion was re-irradiated with 5 Gy 5 times, meaning a total of 25 Gy...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454268/tcrp1-expression-is-associated-with-platinum-sensitivity-in-human-lung-and-ovarian-cancer-cells
#6
Xiaorong Liu, Meiling Feng, Guopei Zheng, Yixue Gu, Chengkun Wang, Zhimin He
Platinum-based drugs, including cisplatin (DDP) and oxaliplatin (L-OHP), are among the most potent chemotherapy drugs, and are widely utilized for the treatment of human lung and ovarian cancer. However, certain patients do not respond to platinum-based agents, and even those who initially benefit from the treatment will eventually exhibit resistance to these drugs. Although certain factors have been investigated for their potential to predict platinum resistance, more effective predictors for the improved management of patients with lung and ovarian cancer are required...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454252/multifactorial-neutropenia-in-a-patient-with-acute-promyelocytic-leukemia-and-associated-large-granular-lymphocyte-expansion-a-case-report
#7
Gianluigi Reda, Bruno Fattizzo, Ramona Cassin, Elena Flospergher, Nicola Orofino, Umberto Gianelli, Wilma Barcellini, Agostino Cortelezzi
Neutropenia in the setting of acute hematological malignancies may impact disease prognosis, thus affecting therapy dose intensity. This is often due to chemotherapy-induced aplasia as well as to the disease itself. However, chronic neutropenia deserves further investigation, as the management of reversible concomitant causes may avoid treatment delay. The present study describes a case of an acute promyelocytic leukemia patient with chronic severe neutropenia of multifactorial origin, including acute leukemia itself, chemotherapy, autoimmune activation with anti-platelets and anti-neutrophil antibodies positivity, and the rare association of large granular lymphocyte (LGL) expansion...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454184/-register-of-difficult-surgical-situations
#8
Michael Korenkov, Henning Dralle, Ernst Klar, Stefan Saad, Norbert Senninger, Jens Standop, Albrecht Stier, Martin Strik, Alexis Ulrich, Rudolf Weiner
Every surgical problem that increases the likelihood of intraoperative and postoperative complications is considered to be a difficult surgical situation. Based on this definition, Korenkov et al. proposed to classify patients according to the following intraoperative difficulty levels (I to IV): (I) ideal situation (easy to operate, no problems), (II) fairly easy/manageable/simple (some minor difficulties may occur), (III) difficult/problematic (difficult to operate; some operative techniques are considerably more difficult than others), and (IV) very difficult (every operative step is difficult/challenging)...
April 28, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28454119/anti-proliferative-and-anti-secretory-effects-of-everolimus-on-human-pancreatic-neuroendocrine-tumors-primary-cultures-is-there-any-benefit-from-combination-with-somatostatin-analogs
#9
Amira Mohamed, David Romano, Alexandru Saveanu, Catherine Roche, Manuela Albertelli, Federica Barbieri, Thierry Brue, Patricia Niccoli, Jean-Robert Delpero, Stephane Garcia, Diego Ferone, Tullio Florio, Vincent Moutardier, Flora Poizat, Anne Barlier, Corinne Gerard
Therapeutic management of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is challenging. The mammalian target of rapamycin (mTOR) inhibitor everolimus recently obtained approval from the Food and Drug Administration for the treatment of patients with advanced pancreatic neuroendocrine tumors (pNETs). Despite its promising antitumor efficacy observed in cell lines, clinical benefit for patients is unsatisfactory. The limited therapeutic potential of everolimus in cancer cells has been attributed to Akt activation due to feedback loops relief following mTOR inhibition...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454112/the-challenge-of-treating-hepatitis-c-virus-associated-cryoglobulinemic-vasculitis-in-the-era-of-anti-cd20-monoclonal-antibodies-and-direct-antiviral-agents
#10
REVIEW
Dario Roccatello, Savino Sciascia, Daniela Rossi, Laura Solfietti, Roberta Fenoglio, Elisa Menegatti, Simone Baldovino
Mixed cryoglobulinemia syndrome (MC) is a systemic vasculitis involving kidneys, joints, skin, and peripheral nerves. While many autoimmune, lymphoproliferative, and neoplastic disorders have been associated with this disorder, hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients. Therefore, clinical research has focused on anti-viral drugs and, more recently, on the new, highly potent Direct-acting Antiviral Agents (DAAs). These drugs assure sustained virologic response (SVR) rates >90%...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454068/biochar-based-water-treatment-systems-as-a-potential-low-cost-and-sustainable-technology-for-clean-water-provision
#11
REVIEW
Willis Gwenzi, Nhamo Chaukura, Chicgoua Noubactep, Fungai N D Mukome
Approximately 600 million people lack access to safe drinking water, hence achieving Sustainable Development Goal 6 (Ensure availability and sustainable management of water and sanitation for all by 2030) calls for rapid translation of recent research into practical and frugal solutions within the remaining 13 years. Biochars, with excellent capacity to remove several contaminants from aqueous solutions, constitute an untapped technology for drinking water treatment. Biochar water treatment has several potential merits compared to existing low-cost methods (i...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28454067/assessment-of-the-swat-model-to-simulate-a-watershed-with-limited-available-data-in-the-pampas-region-argentina
#12
Martín Romagnoli, Margarita Portapila, Alfredo Rigalli, Gisela Maydana, Martín Burgués, Carlos M García
Argentina has been among the world leaders in the production and export of agricultural products since the 1990s. The Carcarañá River Lower Basin (CRLB), a cropland of the Pampas region supplied by extensive rainfall, is located in an area with few streamgauging and other hydrologic/water-quality stations. Therefore, limited hydrologic data are available resulting in limited water-resources assessment. This work explores the application of Soil and Water Assessment Tool (SWAT) model to the CRLB in the Santa Fe province of the Pampas region...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454053/source-identification-and-exchangeability-of-heavy-metals-accumulated-in-vegetable-soils-in-the-coastal-plain-of-eastern-zhejiang-province-china
#13
Xu Qiutong, Zhang Mingkui
Vegetable production in China is suffering increasingly heavy metal damages from various pollution sources including agricultural, industrial and other activities. It is of practical significance to understand the effects of human activities on the accumulation and exchangeability of soil heavy metals in vegetable fields. In this study, seventy-two arable layer samples of vegetable soils were collected from the Shaoxing coastal plain, a representative region of the coastal plain of eastern Zhejiang province, China for characterizing the effects of fertilization methods on accumulation and exchangeable heavy metals in soils (Exchangeable heavy metals in the soil samples were extracted by 0...
April 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28454039/land-cover-change-during-a-period-of-extensive-landscape-restoration-in-ningxia-hui-autonomous-region-china
#14
Angela M Cadavid Restrepo, Yu Rong Yang, Nicholas A S Hamm, Darren J Gray, Tamsin S Barnes, Gail M Williams, Ricardo J Soares Magalhães, Donald P McManus, Danhuai Guo, Archie C A Clements
Environmental change has been a topic of great interest over the last century due to its potential impact on ecosystem services that are fundamental for sustainable development and human well-being. Here, we assess and quantify the spatial and temporal variation in land cover in Ningxia Hui Autonomous Region (NHAR), China. With high-resolution (30m) imagery from Landsat 4/5-TM and 8-OLI for the entire region, land cover maps of the region were created to explore local land cover changes in a spatially explicit way...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454032/identifying-spatial-clusters-of-flood-exposure-to-support-decision-making-in-risk-management
#15
Veronika Röthlisberger, Andreas P Zischg, Margreth Keiler
A sound understanding of flood risk drivers (hazard, exposure and vulnerability) is essential for the effective and efficient implementation of risk-reduction strategies. In this paper, we focus on 'exposure' and study the influence of different methods and parameters of flood exposure analyses in Switzerland. We consider two types of exposure indicators and two different spatial aggregation schemes: the density of exposed assets (exposed numbers per km(2)) and the ratios of exposed assets (share of exposed assets compared to total amount of assets in a specific region) per municipality and per grid cells of similar size as the municipalities...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454031/automatic-and-adaptive-paddy-rice-mapping-using-landsat-images-case-study-in-songnen-plain-in-northeast-china
#16
Bingwen Qiu, Difei Lu, Zhenghong Tang, Chongcheng Chen, Fengli Zou
Spatiotemporal explicit information on paddy rice distribution is essential for ensuring food security and sustainable environmental management. Paddy rice mapping algorithm through the Combined Consideration of Vegetation phenology and Surface water variations (CCVS) has been efficiently applied based on the 8day composites time series datasets. However, the great challenge for phenology-based algorithms introduced by unpromising data availability in middle/high spatial resolution imagery, such as frequent cloud cover and coarse temporal resolution, remained unsolved...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454025/review-and-analysis-of-strengths-and-weaknesses-of-agro-ecosystem-models-for-simulating-c-and-n-fluxes
#17
REVIEW
Lorenzo Brilli, Luca Bechini, Marco Bindi, Marco Carozzi, Daniele Cavalli, Richard Conant, Cristopher D Dorich, Luca Doro, Fiona Ehrhardt, Roberta Farina, Roberto Ferrise, Nuala Fitton, Rosa Francaviglia, Peter Grace, Ileana Iocola, Katja Klumpp, Joël Léonard, Raphaël Martin, Raia Silvia Massad, Sylvie Recous, Giovanna Seddaiu, Joanna Sharp, Pete Smith, Ward N Smith, Jean-Francois Soussana, Gianni Bellocchi
Biogeochemical simulation models are important tools for describing and quantifying the contribution of agricultural systems to C sequestration and GHG source/sink status. The abundance of simulation tools developed over recent decades, however, creates a difficulty because predictions from different models show large variability. Discrepancies between the conclusions of different modelling studies are often ascribed to differences in the physical and biogeochemical processes incorporated in equations of C and N cycles and their interactions...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454014/reduced-mouse-allergen-is-associated-with-epigenetic-changes-in-regulatory-genes-but-not-mouse-sensitization-in-asthmatic-children
#18
Rachel L Miller, Hanjie Zhang, Jacqueline Jezioro, Mariangels De Planell Saguer, Stephanie Lovinsky-Desir, Xinhua Liu, Matthew Perzanowski, Adnan Divjan, Wanda Phipatanakul, Elizabeth C Matsui
Chronic exposure to mouse allergen may contribute greatly to the inner-city asthma burden. We hypothesized that reducing mouse allergen exposure may modulate the immunopathology underlying symptomatic pediatric allergic asthma, and that this occurs through epigenetic regulation. To test this hypothesis, we studied a cohort of mouse sensitized, persistent asthmatic inner-city children undergoing mouse allergen-targeted integrated pest management (IPM) vs education in a randomized controlled intervention trial...
April 25, 2017: Environmental Research
https://www.readbyqxmd.com/read/28453991/advocacy-coalitions-and-protected-areas-creation-process-case-study-in-the-amazon
#19
Sandra Nicolle, Maya Leroy
Protected areas are the cornerstones of conservation policies worldwide. However, only few researches are led to analyse the way they emerge, except for criticising top-down governmental choices. Yet, the historical approach and strategic analysis of public policy building over the long term allows a better understanding of the stakes of action capacity of these policies. We therefore mobilize the advocacy coalition framework to show that protected areas creation is always due to coalitions of actors who belong to different professional fields and act at different scales but nevertheless share common stakes...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28453988/conservation-program-delivery-in-the-southern-u-s-preferences-and-interactions
#20
Christopher S Galik, Robert K Grala
A lingering challenge in implementation of ecosystem-based planning is translating high-level conservation objectives to discrete management initiatives. Recent research underscores this, emphasizing the importance of the processes by which plans are developed and how programs to implement plans are delivered to stakeholders. This study contributes to the existing program design, research methodology, and conservation practice literature through an assessment of landowner and conservation practitioner relationships in the Gulf Coastal Plains and Ozarks (GCPO) region of the southern U...
April 25, 2017: Journal of Environmental Management
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