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https://www.readbyqxmd.com/read/27878051/anticholinergics-for-overactive-bladder-temporal-trends-in-prescription-and-treatment-persistence
#1
Christopher J D Wallis, Colin Lundeen, Nicole Golda, Hilary Brotherhood, Peter Pommerville, Lesley Carr
INTRODUCTION: We sought to understand the contemporary pharmacologic management of overactive bladder (OAB) in a single-payer system. We examined temporal trends in the use of anticholinergic medications and assessed whether the likelihood of patients changing their anticholinergic therapy was predicted by their current therapy. METHODS: We conducted a retrospective, population-based analysis of prescription records from the PharmaNet database in BC, Canada. We identified patients treated with one or more anticholinergic prescriptions between 2001 and 2009...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27581216/serum-neurofilament-light-chain-protein-is-a-measure-of-disease-intensity-in-frontotemporal-dementia
#2
Jonathan D Rohrer, Ione O C Woollacott, Katrina M Dick, Emilie Brotherhood, Elizabeth Gordon, Alexander Fellows, Jamie Toombs, Ronald Druyeh, M Jorge Cardoso, Sebastien Ourselin, Jennifer M Nicholas, Niklas Norgren, Simon Mead, Ulf Andreasson, Kaj Blennow, Jonathan M Schott, Nick C Fox, Jason D Warren, Henrik Zetterberg
OBJECTIVE: To investigate serum neurofilament light chain (NfL) concentrations in frontotemporal dementia (FTD) and to see whether they are associated with the severity of disease. METHODS: Serum samples were collected from 74 participants (34 with behavioral variant FTD [bvFTD], 3 with FTD and motor neuron disease and 37 with primary progressive aphasia [PPA]) and 28 healthy controls. Twenty-four of the FTD participants carried a pathogenic mutation in C9orf72 (9), microtubule-associated protein tau (MAPT; 11), or progranulin (GRN; 4)...
September 27, 2016: Neurology
https://www.readbyqxmd.com/read/27573732/endogamy-consanguinity-and-the-health-implications-of-changing-marital-choices-in-the-uk-pakistani-community
#3
Neil Small, Alan H Bittles, Emily S Petherick, John Wright
The biraderi (brotherhood) is a long-established, widely prevalent dimension of social stratification in Pakistani communities worldwide. Alongside consanguinity, it offers a route for cementing social solidarities and so has strong socio-biological significance. A detailed breakdown of biraderi affiliation among participants in an ongoing birth cohort study in the northern English city of Bradford is presented. There is historical resilience of intra-biraderi marriage, but with a secular decline in prevalence across all biraderi and considerable reductions in some...
August 30, 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/27176903/emergency-and-disaster-preparedness-of-school-transportation-staff-and-school-buses-in-the-united-states-compliance-with-recommendations-for-school-transportation-safety
#4
Robert P Olympia, Christopher Weber, Jodi Brady, Susana Ho
OBJECTIVE: The aim of the study was to determine the compliance of school transportation staff and school buses with recommendations for the safe transportation of children to and from school and school-related activities. METHODS: An electronic questionnaire was distributed to school transportation staff represented by the International Brotherhood of Teamsters during the 2013-2014 academic year. RESULTS: Analysis was performed on 558 completed questionnaires (13% usable response rate)...
May 12, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26846319/provider-father-and-bro-sedentary-m%C3%A4-ori-men-and-their-thoughts-on-physical-activity
#5
Isaac Warbrick, Denise Wilson, Amohia Boulton
BACKGROUND: Māori (indigenous peoples of New Zealand) men have a disproportionate prevalence of lifestyle-related illnesses and are targeted for national physical activity initiatives. While physical activity impacts on physical and mental health and overall wellbeing, current approaches to health promotion often lack cultural relevance. Having better understanding and incorporating relevant cultural values and motivators into program designs could improve the success of health initiatives for indigenous and minority men...
2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/26707179/consanguinity-genetics-and-definitions-of-kinship-in-the-uk-pakistani-population
#6
A H Bittles, N A Small
Consanguineous marriage is a controversial topic in many Western societies, with attention mainly focused on the health of immigrant communities from Asia and Africa. In the UK consanguinity is especially prevalent in the Pakistani community, which now numbers over 1.1 million. Less attention has been paid to the influence of hereditary population stratification within Pakistani communities, in particular biraderi (literally brotherhood) membership, which denotes male lineages that largely govern marriage partner choice and hence the transmission of disease genes...
November 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/26673261/efficient-non-toxic-anion-transport-by-synthetic-carriers-in-cells-and-epithelia
#7
Hongyu Li, Hennie Valkenier, Luke W Judd, Peter R Brotherhood, Sabir Hussain, James A Cooper, Ondřej Jurček, Hazel A Sparkes, David N Sheppard, Anthony P Davis
Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein...
January 2016: Nature Chemistry
https://www.readbyqxmd.com/read/26585680/natural-history-complications-and-re-intervention-rates-of-asymptomatic-residual-stone-fragments-after-ureteroscopy-a-report-from-the-edge-research-consortium
#8
Ben H Chew, Hilary L Brotherhood, Roger L Sur, An Qi Wang, Bodo E Knudsen, Courtney Yong, Tracy Marien, Nicole L Miller, Amy E Krambeck, Cameron Charchenko, Mitchell R Humphreys
PURPOSE: Fragments 4 mm or smaller after ureteroscopy historically have been considered clinically insignificant but there is a reported 20% event rate on followup even with stones 4 mm or smaller. In this study we examine the natural history, complications and re-intervention rates of fragments after ureteroscopy. MATERIALS AND METHODS: Data from 6 centers were collected retrospectively from members of the Endourology Disease Group for Excellence in 232 patients who had residual fragments after ureteroscopy between 2006 and 2013...
April 2016: Journal of Urology
https://www.readbyqxmd.com/read/26461218/-islam-and-caring
#9
Sihem Nadir
There are more and more followers of the Muslim religion in France. All caregivers need to understand the fundamental principles that their Muslim patients hold sacred in the area of health and care. For Muslims, it is of utmost importance to observe the fundamentals of Islam and the values of brotherhood, tolerance, fairness and truth are essential.
October 2015: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/26237544/finding-the-door-critical-incidents-facilitating-gang-exit-among-indigenous-men
#10
Alanaise Goodwill, F Ishu Ishiyama
OBJECTIVE: Our aim was to generate a categorical scheme to describe how participants exited from gang life. METHOD: We utilized the CIT (Butterfield, Borgen, Amundson, & Maglio, 2005; Flanagan, 1954; Woolsey, 1986) and explored gang exit processes among 10 Indigenous men living in Manitoba and Saskatchewan, Canada. Participants responded to the question: What facilitated gang exit for you? RESULTS: They provided 136 critical incidents that were organized into 13 categories of behaviors and experiences that facilitated their exit from gang life: (a) working in the legal workforce, (b) accepting support from family or girlfriend, (c) helping others stay out of gang life, (d) not wanting to go back to jail, (e) accepting responsibility for family, (f) accepting guidance and protection, (g) participating in ceremony, (h) avoiding alcohol, (i) publically expressing that you were out of the gang, (j) wanting legit relationships outside gangs, (k) experiencing a native brotherhood, (l) stopping self from reacting like a gangster, and (m) acknowledging the drawbacks of gang violence...
July 2016: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/26228435/the-relationship-between-nociceptive-brain-activity-spinal-reflex-withdrawal-and-behaviour-in-newborn-infants
#11
Caroline Hartley, Sezgi Goksan, Ravi Poorun, Kelly Brotherhood, Gabriela Schmidt Mellado, Fiona Moultrie, Richard Rogers, Eleri Adams, Rebeccah Slater
Measuring infant pain is complicated by their inability to describe the experience. While nociceptive brain activity, reflex withdrawal and facial grimacing have been characterised, the relationship between these activity patterns has not been examined. As cortical and spinally mediated activity is developmentally regulated, it cannot be assumed that they are predictive of one another in the immature nervous system. Here, using a new experimental paradigm, we characterise the nociceptive-specific brain activity, spinal reflex withdrawal and behavioural activity following graded intensity noxious stimulation and clinical heel lancing in 30 term infants...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26038860/-santa-casa-de-miseric%C3%A3-rdia-and-hygienist-policies-in-bel%C3%A3-m-do-par%C3%A3-in-the-late-nineteenth-century
#12
Cybelle Salvador Miranda, Jane Felipe Beltrão, Márcio Couto Henrique, Brena Tavares Bessa
The article analyzes the relationship between hygienist policies in effect in Belém in the late nineteenth century and the expansion of activities of the Santa Casa de Misericórdia do Pará. Considered one of the first hospital institutions in the former Grão-Pará Province, in addition to its own hospital, the Brotherhood administered several other health facilities in the capital, and the study of its physical displacement made it possible to "map" three health centers in Belém: Pioneer, Expansion and the Santa Casa, which reinforce the growth vectors of the city...
January 2015: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/25960541/wa29%C3%A2-we-are-all-one-compassionate-cities-a-global-community-joined-for-care
#13
Emilio Herrera Molina, Silvia Librada Flores
BACKGROUND: The NewHealth Foundation, a Spanish non-for-profit organisation, is leading the project Compassionate Cities. "We are all one". The project aims to involve citizens in creating communities of care to help people at the end of life phase. AIM: To design and develop a practical model to engage communities in the process of improving the quality of public palliative care. To empower key advocates of end-of-life care. To evaluate communities' interventions, their feasibility and impact in terms of shared benefit for stakeholders...
April 2015: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/25953708/brotherhood-of-genetics-and-preventive-medication
#14
EDITORIAL
Heribert Schunkert
No abstract text is available yet for this article.
July 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25871627/the-language-skeleton-after-dissecting-meaning-a-functional-segregation-within-broca-s-area
#15
Tomás Goucha, Angela D Friederici
Broca's area is proposed as a crucial brain area for linguistic computations. Language processing goes beyond word-level processing, also implying the integration of meaningful information (semantics) with the underlying structural skeleton (syntax). There is an on-going debate about the specialisation of the subregions of Broca's area-Brodmann areas (BA) 44 and 45-regarding the latter aspects. Here, we tested if syntactic information is specifically processed in BA 44, whereas BA 45 is mainly recruited for semantic processing...
July 1, 2015: NeuroImage
https://www.readbyqxmd.com/read/25807363/-santa-casa-de-miseric%C3%A3-rdia-and-hygienist-policies-in-bel%C3%A3-m-do-par%C3%A3-in-the-late-nineteenth-century
#16
Cybelle Salvador Miranda, Jane Felipe Beltrão, Márcio Couto Henrique, Brena Tavares Bessa
The article analyzes the relationship between hygienist policies in effect in Belém in the late nineteenth century and the expansion of activities of the Santa Casa de Misericórdia do Pará. Considered one of the first hospital institutions in the former Grão-Pará Province, in addition to its own hospital, the Brotherhood administered several other health facilities in the capital, and the study of its physical displacement made it possible to "map" three health centers in Belém: Pioneer, Expansion and the Santa Casa, which reinforce the growth vectors of the city...
March 20, 2015: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/25132898/a-surgical-challenge-idiopathic-scrotal-elephantiasis
#17
Hilary Laurel Brotherhood, Michael Metcalfe, Larry Goldenberg, Peter Pommerville, Cameran Bowman, David Naysmith
Scrotal elephantiasis is a condition rarely encountered in developed nations. It is endemic in tropical regions due to the presence of filariasis (Wucheria bancrofti). We report 2 cases of idiopathic scrotal elephantiasis in Canadian citizens with no history of travel to endemic filariasis regions, malignancy, surgery or radiation. Both patients underwent complete excision of the involved tissue with reconstruction. We found that for advanced cases of scrotal lymphedema, surgery is currently the only solution...
July 2014: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/25003545/coronary-artery-plaque-burden-and-calcium-scores-in-healthy-men-adhering-to-long-term-wine-drinking-or-alcohol-abstinence
#18
COMPARATIVE STUDY
P L da Luz, S Coimbra, D Favarato, C Albuquerque, R I Mochiduky, C E Rochitte, E Hojaij, C R L Gonsalves, F R Laurindo
Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound...
August 2014: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/24673606/the-neural-fate-of-neutral-information-in-emotion-enhanced-memory
#19
Sarah Watts, Luciano G Buratto, Emilie V Brotherhood, Gemma E Barnacle, Alexandre Schaefer
In this study, we report evidence that neural activity reflecting the encoding of emotionally neutral information in memory is reduced when neutral and emotional stimuli are intermixed during encoding. Specifically, participants studied emotional and neutral pictures organized in mixed lists (in which emotional and neutral pictures were intermixed) or in pure lists (only-neutral or only-emotional pictures) and performed a recall test. To estimate encoding efficiency, we used the Dm effect, measured with event-related potentials...
July 2014: Psychophysiology
https://www.readbyqxmd.com/read/24634006/molecular-physiology-of-the-tensin-brotherhood-of-integrin-adaptor-proteins
#20
REVIEW
Donald T Haynie
Numerous proteins have been identified as constituents of the adhesome, the totality of molecular components in the supramolecular assemblies known as focal adhesions, fibrillar adhesions and other kinds of adhesive contact. The transmembrane receptor proteins called integrins are pivotal adhesome members, providing a physical link between the extracellular matrix (ECM) and the actin cytoskeleton. Tensins are ever more widely investigated intracellular adhesome constituents. Involved in cell attachment and migration, cytoskeleton reorganization, signal transduction and other processes relevant to cancer research, tensins have recently been linked to functional properties of deleted in liver cancer 1 (DLC1) and a mitogen-activated protein kinases (MAPK), to cell migration in breast cancer, and to metastasis suppression in the kidney...
July 2014: Proteins
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