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https://www.readbyqxmd.com/read/29352844/hypoalbuminaemia-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-incidence-and-significance
#1
Peng-Cheng Xu, Zhi-Ying Tong, Tong Chen, Shan Gao, Shui-Yi Hu, Xiao-Wei Yang, Tie-Kun Yan, Shan Lin
OBJECTIVES: Hypoalbuminaemia has been proved to be a biomarker of poor prognosis in many diseases. The objective of this study was to investigate the significance of hypoalbuminaemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Data of 117 AAV patients were analysed retrospectively. The relationship between hypoalbuminaemia and disease severity were studied. The influence of albumin on the pathogenetic role of ANCA was investigated in vitro...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29336783/bronchiectasis-is-highly-prevalent-in-anti-mpo-anca-associated-vasculitis-and-is-associated-with-a-distinct-disease-presentation
#2
Antoine Néel, Alexandra Espitia-Thibault, Pierre-Paul Arrigoni, Christelle Volteau, Marie Rimbert, Agathe Masseau, Christian Agard, Fadi Fakhouri, Renan Liberge, Mohamed Hamidou
OBJECTIVES: To assess the prevalence of bronchiectasis in a Western cohort with ANCA-positive granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and its correlations with disease presentation and outcome. METHODS: Retrospective study of ANCA-associated vasculitis (AAV) patients followed at Nantes University Hospital (2005-2015). Clinical, biological, and follow-up data were collected through chart review. Two experienced radiologists blinded to the clinical data interpreted chest high-resolution CTs according to the Feischner Society criteria...
December 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29329643/iga-nephropathy-and-iga-vasculitis-with-nephritis-have-a-shared-feature-involving-galactose-deficient-iga1-oriented-pathogenesis
#3
Hitoshi Suzuki, Junichi Yasutake, Yuko Makita, Yuki Tanbo, Kohei Yamasaki, Tadashi Sofue, Toshiki Kano, Yusuke Suzuki
Galactose-deficient IgA1 has been proposed as an important effector molecule in IgA nephropathy (IgAN). We previously showed that the galactose-deficient IgA1-specific monoclonal antibody KM55 can detect circulating galactose-deficient IgA1 in patients with IgAN, enabling us to study the molecular roles of galactose-deficient IgA1. Herein, we further examined the pathophysiological significance of galactose-deficient IgA1 in glomerular deposits of patients with IgAN by immunohistochemistry using KM55. Immunostaining of galactose-deficient IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens from 48 patients with IgAN and 49 patients with other renal diseases such as lupus nephritis, HCV-related nephropathy, IgA vasculitis with nephritis (IgA-VN), and membranous nephropathy...
January 9, 2018: Kidney International
https://www.readbyqxmd.com/read/29326157/targeting-b-cells-and-plasma-cells-in-glomerular-diseases-translational-perspectives
#4
Eva Schrezenmeier, David Jayne, Thomas Dörner
The unique contributions of memory B cells and plasma cells in kidney diseases remain unclear. In this review, we evaluate the clinical experience with treatments directed at B cells, such as rituximab, and at plasma cells, such as proteasome inhibition, to shed light on the role of these two B lineage compartments in glomerular diseases. Specifically, analysis of these targeted interventions in diseases such as ANCA-associated vasculitis, SLE, and antibody-mediated transplant rejection permits insight into the pathogenetic effect of these cells...
January 11, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29319773/anca-positive-pauci-immune-crescentic-glomerulonephritis-in-a-patient-with-systemic-lupus-erythematosus
#5
Percy Herrera-Añazco, Percy Velásquez-Castillo, Josmel Pacheco-Mendoza, Germán Valenzuela-Rodriguez, Carmen Asato-Higa
The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29302827/colonic-perforation-due-to-severe-cytomegalovirus-disease-in-granulomatosis-with-polyangiitis-after-immunosuppression
#6
REVIEW
Alessandra Soriano, Nazareno Smerieri, Stefano Bonilauri, Loredana De Marco, Alberto Cavazza, Carlo Salvarani
Granulomatosis with polyangiitis (GPA) is a small-vessel necrotizing granulomatous vasculitis typically involving upper airways, lungs, and kidneys, which may lead to end-organ damage and life-threatening complications. Major infections during GPA course represent a considerable concern in the management of the disease. Cytomegalovirus (CMV) infection and disease are rare but significant complications in the course of GPA being associated with high morbidity and mortality rates. Colonic perforation due to CMV colitis is exceedingly rare and has so far almost exclusively been documented in HIV, renal transplant, and systemic lupus erythematosus patients...
January 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29301807/acute-alveolar-haemorrhage-in-hepatitis-c-related-cryoglobulinaemic-vasculitis
#7
Theepika Rajkumar, Eswari Vilayur
We describe a patient with untreated hepatitis C virus (HCV) infection presenting with pulmonary renal syndrome. He rapidly developed bilateral lung infiltrates and respiratory failure, and bronchoscopy confirmed acute alveolar haemorrhage secondary to cryoglobulinaemic vasculitis. Early bronchoscopy to confirm the diagnosis and consequent institution of immunosuppressive therapy led to excellent outcomes, which otherwise is reported in the literature to carry significant mortality. Therefore, in patients with HCV presenting with bilateral lung infiltrates, physicians must maintain a high degree of clinical suspicion for alveolar haemorrhage secondary to cryoglobulinaemic vasculitis...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29299823/clinicopathological-study-of-male-and-female-patients-with-lupus-nephritis-a-retrospective-study
#8
Wei Peng, Yi Tang, Li Tan, Wei Qin
PURPOSE: The aim of this study was to assess the impact of sex on long-term outcomes in patients with lupus nephritis (LN). METHODS: Data of patients were collected at a single tertiary hospital from June 2010 to June 2016. Clinicopathological features and treatment responses of LN patients with different genders were compared. The primary endpoint was serum creatinine level doubled, GFR < 15 mL/min, initiation of renal replacement treatment or death. The secondary endpoint was complete remission or partial remission...
January 3, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29289268/rhabdomyolysis-associated-acute-kidney-injury-with-normal-creatine-phosphokinase
#9
Faisal Kamal, Lindsay Snook, Jagannath H Saikumar
Rhabdomyolysis is a syndrome characterized by the breakdown of skeletal muscle and leakage of intracellular myocyte contents, such as creatine phosphokinase (CPK) and myoglobin, into the interstitial space and plasma resulting in acute kidney injury (AKI). Elevated CPK of at least 5 times the upper limit of normal is an important diagnostic marker of Rhabdomyolysis. We present a case of rhabdomyolysis with severe AKI with a normal CPK at presentation. A 32-year-old man presented with acute respiratory failure and AKI after an overdose of recreational drugs...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29287588/relation-between-duration-of-the-prodromal-phase-and-renal-damage-in-anca-associated-vasculitis
#10
Eline Houben, Stefanie L Groenland, Joost W van der Heijden, Alexandre E Voskuyl, Hiëronymus J Doodeman, Erik L Penne
BACKGROUND: In ANCA-associated vasculitis the acute phase of the disease is often preceded by prodromal symptoms. The aim of the present study was to analyze the relation between the duration of the prodromal phase and renal damage. METHODS: Patients with ANCA-associated vasculitis and renal involvement from a retrospective single-center cohort were divided into two equal groups based on the duration of the prodromal phase. The prodromal phase was defined as the time between first vasculitis related symptoms and the date of diagnosis...
December 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29287586/the-impact-of-intravenous-methylprednisolone-pulses-on-renal-survival-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-with-severe-renal-injury-patients-a-retrospective-study
#11
Yanhong Ma, Fei Han, Liangliang Chen, Hongya Wang, Haidongqing Han, Binfeng Yu, Ying Xu, Jianghua Chen
BACKGROUND: High-dose methylprednisolone pulses were one of the main treatments for anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitides (AAV) but had obvious side effects. We aimed to know the impact on renal survival and identify the prognostic factors of this treatment in Chinese AAV patients with severe renal involvement. METHODS: One hundred and eleven AAV patients with an estimated glomerular filtration rate (eGFR) of 10ml/min/1.73 m2 or less at admission were included...
December 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29285157/serum-creatinine-level-and-esr-values-associated-to-clinical-pathology-types-and-prognosis-of-patients-with-renal-injury-caused-by-anca-associated-vasculitis
#12
Hongda Liang, Miaomiao Xin, Lei Zhao, Liqin Wang, Mingshu Sun, Jibo Wang
The correlation between serum creatinine and erythrocyte sedimentation rate (ESR) values and clinical pathology and prognosis in patients with renal injury caused by anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis were analyzed. Eighty-six patients with ANCA-associated vasculitis (AAV) treated in the Affiliated Hospital of Qingdao University were enrolled in the study. Patients were assigned into an elderly group (n=45) or a non-elderly group (n=41) according to age. The serum creatinine (Scr) level was measured via the sarcosine oxidase method, and the erythrocyte sedimentation rate (ESR) was measured using the full-automatic ESR analyzer; the relationship between Scr and ESR values and the pathology type of patients was statistically analyzed...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29247347/patient-and-physician-perspectives-on-the-impact-of-health-related-quality-of-life-in-mexican-patients-with-anca-associated-vasculitis
#13
Andrea Hinojosa-Azaola, Ariadna Jiménez-González, Natasha Alcocer-Castillejos
The objective of this study is to describe aspects of health-related quality of life (HRQOL) in Mexican patients with antineutrophil cytoplasmic-associated vasculitis (AAV). Cross-sectional comparison study includes patients with established AAV and a comparison group with rheumatoid arthritis (RA), chronic kidney disease (CKD), and healthy subjects. Variables considered were: socio-demographic data, comorbidities, laboratory, disease activity, damage, and Physician's and Patient's Global Assessment (PhGA and PtGA)...
December 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29247314/long-term-outcomes-of-daily-oral-vs-pulsed-intravenous-cyclophosphamide-in-a-non-trial-setting-in-anca-associated-vasculitis
#14
Jonathan La-Crette, Jeremy Royle, Peter C Lanyon, Alastair Ferraro, Amanda Butler, Fiona A Pearce
We aimed to compare risk of death, relapse, neutropenia and infection requiring hospital admission between unselected ANCA-associated vasculitis (AAV) patients according to whether cyclophosphamide induction was by daily oral (PO) or pulse intravenous (IV) route. We identified all newly diagnosed AAV patients treated with PO or IV cyclophosphamide between March 2007 and June 2013. We used Cox and logistic regression models to compare mortality, relapse and adverse events and adjusted these for age, renal function and other significant confounders...
December 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29243035/systemic-lupus-erythematosus-and-ocular-involvement-an-overview
#15
REVIEW
Rosanna Dammacco
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. An early diagnosis and the adoption of suitable therapeutic measures are necessary to prevent sight-threatening consequences, especially in patients with juvenile SLE. Periocular lesions, such as eyelid involvement and orbital inflammation, are relatively rare and, in case of orbital masses, may require a biopsy control...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29241772/location-of-skin-lesions-in-henoch-sch%C3%A3-nlein-purpura-and-its-association-with-significant-renal-involvement
#16
COMPARATIVE STUDY
Jessica St John, Priyanka Vedak, Anna Cristina Garza-Mayers, Mai P Hoang, Sagar U Nigwekar, Daniela Kroshinsky
BACKGROUND: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis. OBJECTIVE: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a predictor of significant renal involvement at the time of the skin biopsy and the months following. METHODS: A retrospective study on renal function from 72 adult patients with skin-biopsy proven HSP...
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241626/c5a-receptor-1-promotes-autoimmunity-neutrophil-dysfunction-and-injury-in-experimental-anti-myeloperoxidase-glomerulonephritis
#17
Jonathan Dick, Poh-Yi Gan, Sharon L Ford, Dragana Odobasic, Maliha A Alikhan, Sven H Loosen, Pam Hall, Clare L Westhorpe, Anqi Li, Joshua D Ooi, Trent M Woodruff, Charles R Mackay, A Richard Kitching, Michael J Hickey, Stephen R Holdsworth
The prospects for complement-targeted therapy in ANCA-associated vasculitis have been enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely replaced glucocorticoids in induction treatment. C5aR1 primes neutrophils for activation by anti-neutrophil cytoplasmic antibody (ANCA) and is therefore required in models of glomerulonephritis induced by anti-myeloperoxidase antibody. Although humoral and cellular autoimmunity play essential roles in ANCA-associated vasculitis, a role for C5aR1 in these responses has not been described...
December 11, 2017: Kidney International
https://www.readbyqxmd.com/read/29228499/high-dose-intravenous-immunoglobulins-for-the-treatment-of-dermatological-autoimmune-diseases
#18
Jochen H O Hoffmann, Alexander H Enk
Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy...
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29207950/persistent-hematuria-in-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-during-clinical-remission-chronic-glomerular-lesion-or-low-grade-active-renal-vasculitis
#19
Li Lv, Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Zhao Hu, Ming-Hui Zhao
BACKGROUND: Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of persistent hematuria during clinical remission in a large cohort of AAV patients. METHODS: A cohort of 219 AAV patients in complete clinical remission after induction therapy at our center was retrospectively studied, and their clinical and laboratory data as well as long-term outcomes were analyzed...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29204761/clinical-value-of-systemic-symptoms-in-iga-nephropathy-with-anca-positivity
#20
Lijiao Xie, Jianghua He, Xing Liu, Sha Tang, Weili Wang, Furong Li, Ying Zhang, Jun Zhang, Yunjian Huang, Jinghong Zhao, Yafei Li, Jingbo Zhang
Our aim was to evaluate the pathogenic role of anti-neutrophil cytoplasmic antibodies (ANCAs) in patients with IgA nephropathy (IgAN). A total of 2390 patients with biopsy-confirmed IgAN were analyzed retrospectively. Thirty-five IgAN patients with ANCA and 40 IgAN patients without ANCA were enrolled. According to the Birmingham Vasculitis Activity Score (BVAS) items, the ANCA-positive patients were further divided into two subgroups which with or without systemic symptoms. The cumulative renal survival rate was calculated using Kaplan-Meier analysis...
December 4, 2017: Clinical Rheumatology
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