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https://www.readbyqxmd.com/read/29456218/renal-anemia-syndromes-in-iraqi-hemodialysis-patients-according-to-iron-status
#1
Ala Ali, Riyadh M Salih
Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456209/assessment-of-prevalence-and-clinical-outcome-of-frailty-in-an-elderly-predialysis-cohort-using-simple-tools
#2
Hatem Ali, Tarek Abdelaziz, Fatima Abdelaal, Jyoti Baharani
The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29450585/effect-of-isolated-vitamin-d-supplementation-on-bone-turnover-markers-in-younger-postmenopausal-women-a-randomized-double-blind-placebo-controlled-trial
#3
J Nahas-Neto, L M Cangussu, C L Orsatti, F N Bueloni-Dias, P F Poloni, E B Schmitt, E A P Nahas
Vitamin D (VD) plays an important role in bone mineralization. The present study investigates the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. It has been shown that VD supplementation in postmenopausal women with hypovitaminosis D is associated with a reduction in bone turnover markers. PURPOSE: The purpose of this study is to evaluate the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. METHODS: In this double-blind, placebo-controlled trial, 160 women were randomized into the VD group (supplementation with 1000 IU of vitamin D3/day, orally; n = 80) or placebo group (n = 80)...
February 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29445220/association-of-admission-serum-levels-of-vitamin-d-calcium-phosphate-magnesium-and-parathormone-with-clinical-outcomes-in-neurosurgical-icu-patients
#4
Seyed Hossein Ardehali, Salman Dehghan, Ahmad Reza Baghestani, Aynaz Velayati, Zahra Vahdat Shariatpanahi
To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210 patients upon admission. Mean serum 25(OH)D was 21.1 ± 7.4 ng/mL. 25(OH)D deficiency (less than 20 ng/dL) and elevated serum parathormone level were found in 47.6% and 38% of patients respectively...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444509/associations-between-intravenous-iron-inflammation-and-fgf23-in-non-dialysis-patients-with-chronic-kidney-disease-stages-3-5
#5
Katarzyna Muras-Szwedziak, Michal Nowicki
BACKGROUND/AIMS: Both iron deficiency and chronic inflammation are highly prevalent in patients with chronic kidney disease (CKD). The effect of intravenous iron infusion on mineral metabolism in CKD may be modified by inflammation. Intravenous iron theraphy may reduce peripheral degradation, secretion, clearence of iFGF23 and lead to hypophosphatemia. The aim of the study was to evaluate the effect of intravenous iron on mineral metabolism in CKD patients. METHODS: 35 non-dialysis patients with CKD stages 3-5...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29414834/phosphate-removal-during-conventional-hemodialysis-a-decades-old-misconception
#6
Rosilene M Elias, Valeria R C Alvares, Rosa M A Moysés
BACKGROUND/AIMS: Hyperphosphatemia is associated with high mortality rate in patients on dialysis. Conventional hemodialysis (HD) is a limit technique in removing phosphate (P). There is a widespread belief that P is removed mainly in the first hour of HD. The aim of this study was to certify the percentage of 1-hour removal of P as compared to the entire procedure. METHODS: data from the first dialysis of the week of 21 patients (13 men, age 44±15 years), for 3 consecutive dialysis sessions were evaluated...
January 31, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29390241/-dystrophic-calcinosis-cutis-a-rare-fearsome-issue-of-chronic-kidney-disease
#7
Luigi Cirillo, Pamela Gallo, Carmela Errichiello, Annasara Sorrentino, Alma Mehmetaj, Marco Gregori, Rossella Cannavò, Giuseppe Cestone, Roberta Cutruzzulà, Pietro Claudio Dattolo
Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma...
February 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29386822/osteitis-fibrosa-cystica-of-mandible-in-hyperparathyroidism-jaw-tumor-syndrome-a-rare-presentation-and-review-of-literature
#8
Anupama Singh Satpathy, Arjun Dasgupta, Chirajit Dutta, N V K Mohan, Shouvanik Satpathy
Brown's tumor, also referred as osteitis fibrosa cystica is a rare nonneoplastic diagnostically challenging consequence of hyperparathyroidism (HPT) which occurs due to increased parathormone secretions in blood, causing excessive calcium resorption from kidneys, bone resorption, and phosphaturia. Brown's tumor is a misnomer, presenting as cystic expansile lesions in bone, often misdiagnosed as neoplastic lesion or granuloma or abscess in bones. It can affect long bones, clavicle, ribs, and pelvis. According to literature, skeletal manifestations of Brown tumor is relatively rare and occurs in <2% of the cases of HPT...
July 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29385112/calcium-phosphate-metabolism-disturbances-in-patients-with-significant-mitral-regurgitation
#9
Olga Możeńska, Jacek Bil, Agnieszka Segiet, Dariusz A Kosior
INTRODUCTION    Although several risk factors associated with cardiovascular diseases (CVDs) are known, new factors continue to be researched. In recent years, clinical trials have reported vitamin D and other calcium-phosphate (Ca-P) metabolism disturbances as potential new risk factors.  OBJECTIVES    Considering the frequency of Ca-P metabolism disturbances and mitral regurgitation (MR) in general population and in patients with CVD, the aim of our study was to assess the extent of Ca-P metabolism disturbances and their potential determining factors in patients with CVD...
January 26, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29379541/vitamin-d-deficiency-is-associated-with-urinary-tract-infection-in-children
#10
Sherein Abdelhamid Shalaby, Nesrein Mosad Handoka, Rasha Emad Amin
Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D 3 ) levels and the risk of first time febrile UTI in children. Material and methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29360693/the-relationship-between-semiquantitative-parameters-derived-from-technetium-99m-metoxyisobutylisonitrile-dual-phase-parathyroid-single-photon-emission-computed-tomography-images-and-disease-severity-in-primary-hyperparathyroidism
#11
Derya Çayir, Mine Araz, Ali Yalçindağ, Erman Çakal
OBJECTIVE: The relationship between multiple semiquantitative indices on technetium-99m metoxyisobutylisonitrile (Tc-99m MIBI) parathyroid single-photon emission computed tomography (SPECT) and clinical, laboratory, and radiological data was investigated in primary hyperparathyroidism. PATIENTS AND METHODS: Ninety-three patients who had a histopathologically confirmed single parathyroid adenoma (PT) were enrolled. Regions of interests were drawn around the PT, neighboring thyroid (T), and background in early and late planar images and isocontour regions of interests around the adenoma in SPECT images (PT SPECT)...
January 22, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29336002/body-composition-and-circulating-estradiol-are-the-main-bone-density-predictors-in-healthy-young-and-middle-aged-men
#12
S C Bilha, D Branisteanu, C Buzduga, D Constantinescu, P Cianga, E Anisie, A Covic, M C Ungureanu
PURPOSE: Current fracture risk assessment options in men call for improved evaluation strategies. Recent research directed towards non-classic bone mass determinants have often yielded scarce and conflicting results. We aimed at investigating the impact of novel potential bone mass regulators together with classic determinants of bone status in healthy young and middle-aged men. METHODS: Anthropometric measurements, all-site bone mineral density (BMD) and body composition parameters assessed by dual-energy X-ray absorptiometry and also serum concentrations of (1) the adipokines leptin and resistin, (2) vitamin D and parathormone (PTH), (3) sex hormone binding globulin (SHBG), total testosterone and estradiol (free testosterone was also calculated) and (4) C-terminal telopeptide of type I collagen (CTx) were obtained from 30 apparently healthy male volunteers aged 20-65 years enrolled in this cross-sectional study...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29331397/persistent-hyperparathyroidism-as-a-risk-factor-for-long-term-graft-failure-the-need-to-discuss-indication-for-parathyroidectomy
#13
Maria Júlia Correia Lima Nepomuceno Araujo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Nahas, Melani Custodio, Rosa M A Moysés, Elias David-Neto
BACKGROUND: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29319776/hypercalcemia-and-acute-renal-insufficiency-following-use-of-a-veterinary-supplement
#14
Marcelo Fernando Ronsoni, Heloisa de Cassia Dos Santos, Bruno da Silveira Colombo, Carina Gabriela Correa, Ana Paula Gomes Moritz, Marisa Helena Cesar Coral, Simone Van de Sande-Lee, Alexandre Hohl
A previously healthy 24 yo male presented with a two-month history of epigastric pain, nausea, vomiting, fatigue and malaise. He reported abuse of different substances, including an injectable veterinary vitamin compound, which contains high doses of vitamin A, D and E, and an oily vehicle that induces local edema and enhances muscle volume. Serum creatinine was 3.1 mg/dL, alanine transaminase 160 mg/dL, aspartate transaminase 11 mg/dL, total testosterone 23 ng/dL, 25-OH-vitamin D >150 ng/mL (toxicity >100), 1,25-OH-vitamin D 80 pg/mL, vitamin A 0...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29306481/effect-of-calcifediol-treatment-on-cardiovascular-outcomes-in-patients-with-acute-coronary-syndrome-and-percutaneous-revascularization
#15
Cristina Navarro-Valverde, Jose M Quesada-Gómez, Ramón Pérez-Cano, Ana Fernández-Palacín, Luis F Pastor-Torres
BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been consistently linked with cardiovascular diseases. However, results of intervention studies are contradictory. The aim of this study was to evaluate the effect of treatment with calcifediol (25(OH)D3) on the cardiovascular system of patients with non-ST-elevation acute coronary syndrome after percutaneous coronary intervention. PATIENTS AND METHODS: A prospective study assessing≥60-year-old patients with non-ST-elevation acute coronary syndrome, coronary artery disease and percutaneous revascularisation...
January 3, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29275894/ambulatory-surgery-under-local-anesthesia-for-parathyroid-adenoma-feasibility-and-outcome
#16
A Benhami, E Chuffart, N Christou, S Liva-Yonnet, M Mathonnet
The aim of this study was to evaluate the results of ambulatory parathyroid resection performed under local anesthesia (LA). MATERIAL AND METHODS: Outpatients undergoing parathyroid adenoma resection by a focused approach under LA were included. Results were evaluated by intraoperative serum parathormone levels (ioPTH) and the balance of phosphate and calcium postoperatively, at 3 months, 1 year and at the point date. The quality of ambulatory care was evaluated by the number of cancelled interventions, the number of patients hospitalized after surgery or during the first postoperative month...
December 21, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29243659/comparative-study-of-the-serum-measurement-of-pth-on-roche-cobas-e411%C3%A2-versus-the-abbott-architect-ci8200%C3%A2
#17
Mohammed Bensalah, Ouardia Bouayadi, Nawal Rahmani, Amina Lyagoubi, Somiya Lamrabat, Mohammed Choukri
Parathormone (PTH) is the main hormone of phosphocalcic homeostasis. It is synthesized and secreted by the parathyroid glands. PTH has become a routine test in the medical biology laboratory. However, its measurement presents analytical difficulties with the various marketed kits. The aim of this work is to present the results of a comparative study between the PTH measurment on Abbott architect ci8200 and on Roche's Cobas e411 automaton. It is a prospective study carried out for 252 hospitalized patients in the various departments of the University Hospital Center Mohammed VI of Oujda...
December 15, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29215447/cross-sectional-study-of-four-serological-bone-turnover-markers-for-the-risk-assessment-of-medication-related-osteonecrosis-of-the-jaw
#18
Andre Peisker, Gregor F Raschke, Mina D Fahmy, Arndt Guentsch, Korosh Roshanghias, Kai C König, Stefan Schultze-Mosgau
BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29181264/evaluation-of-bone-mineral-density-and-related-parameters-in-patients-with-haemophilia-a-single-center-cross-sectional-study
#19
Hatice Demet Kiper Unal, Melda Comert Ozkan, Fatos Dilan Atilla, Zuhal Demirci, Nur Soyer, Ilgin Yildirim Simsir, Ozgur Omur, Kazim Capaci, Guray Saydam, Fahri Sahin
Haemophilia has been associated with low bone mineral density (BMD) probably due to some predisposing factors. The aim of this study was to evaluate the relationship between BMD and potential clinical predictors in adult haemophilic patients. Fortynine patients with moderate and severe haemophilia were enrolled. BMD was measured by Dual Energy X-Ray Absorptiometry (DXA) and blood tests were performed for vitamin D, calcium, phosphore, alkaline phosphatase and parathormone levels. Functional Independence Score in Haemophilia (FISH) and Haemophilia Joint Health Score (HJHS) were used to assess musculoskeletal functions...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/29174058/intraoperative-pth-spikes-during-parathyroidectomy-may-be-associated-with-multiglandular-disease
#20
Richard Teo, Josefina C Farrá, Zahra F Khan, Andrea R Marcadis, John I Lew
BACKGROUND: The importance of intraoperative parathormone (ioPTH) "spikes" during parathyroidectomy (PTX) remains unclear. This study compared patients with and without ioPTH spikes during PTX using the criterion of a > 50% PTH, and determined the effect of ioPTH spikes on operative outcome. METHODS: We performed a retrospective review of prospectively collected data of 683 patients who underwent PTX guided by ioPTH monitoring. An ioPTH "spike value' (SV) was calculated by subtracting the pre-incision ioPTH value (PI) from pre-excision ioPTH value (PE) (SV = PE - PI)...
November 21, 2017: Surgery
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