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https://www.readbyqxmd.com/read/28431568/a-case-report-of-severe-calciphylaxis-suggested-approach-for-diagnosis-and-treatment
#1
Margret Patecki, Gabriele Lehmann, Jan Hinrich Bräsen, Jessica Schmitz, Anna Bertram, Lars Daniel Berthold, Hermann Haller, Wilfried Gwinner
BACKGROUND: Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. We report a case which clearly illustrates that knowledge of the underlying bone disorder is essential for a directed treatment. Based on this experience we discuss a systematic diagnostic and therapeutic approach in patients with calciphylaxis...
April 21, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28424141/can-parathormon-levels-after-ipsilateral-lobectomy-predict-postoperative-hypocalcemia-in-patients-undergoing-total-thyroidectomy
#2
Fatih Kul, Turkay Kirdak, Pinar Sarkut, Gokhan Ocakoglu, Nusret Korun
The purpose of this study was to investigate the relationship between the serum parathormone (PTH) levels measured after completion of hemithyroidectomy on the first side during total thyroidectomy and the postoperative hypocalcemia. The patients were divided into two groups, as those who demonstrated a decrease in PTH levels measured after completion of hemithyroidectomy of the first side (Group 1, n = 43) and those who did not demonstrate a decrease in PTH levels (Group 2, n = 24). The serum PTH levels were measured just before the incision (PTHi), when the hemithyroidectomy stage had been completed (PTHht), at the end of the operation (PTHtt), and at the postoperative 24th hour (PTH24hr)...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28416255/differences-between-2nd-and-3rd-generation-seric-parathormone-determination-methods-on-mortality-in-haemodialysis-patients
#3
Laura Rodríguez-Osorio, Concepción de la Piedra, Mercedes Rupert, Marta Martín-Fernández, María Luisa González Casaus, Carolina Gracia-Iguacel, Jesús Egido, Ricardo Villa-Bellosta, Emilio González Parra
Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). OBJECTIVE: To evaluate the differences in mortality of dialysis patients between both assays to measure PTH, as well as the possible prognostic role of the PTHbio/iPTH ratio. METHODS: 145 haemodialysis patients were included with 2-year monitoring including baseline laboratory test and annually thereafter...
April 14, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28396941/effect-of-the-timing-of-dialysis-initiation-on-left-ventricular-hypertrophy-and-%C3%A4-nflammation-in-pediatric-patients
#4
Sevcan A Bakkaloğlu, Yaşar Kandur, Erkin Serdaroğlu, Aytül Noyan, Aysun Karabay Bayazıt, Lale Sever, Sare Gülfem Özlü, Gül Özçelik, İsmail Dursun, Caner Alparslan
BACKGROUND: The optimal time for dialysis initiation in adults and children with chronic kidney disease remains unclear. The aim of this study was to evaluate the impact of dialysis timing on different outcome parameters, in particular left ventricular (LV) morphology and inflammation, in pediatric patients receiving peritoneal dialysis and hemodialysis. METHODS: The medical records of pediatric dialysis patients who were followed-up in nine pediatric nephrology centers in Turkey between 2008 and 2013 were retrospectively reviewed...
April 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28362510/apoptosis-in-primary-hyperparathyroidism
#5
Oliwia Anna Segiet, Łukasz Mielańczyk, Adam Piecuch, Marek Michalski, Szczepan Tyczyński, Marlena Brzozowa-Zasada, Mariusz Deska, Romuald Wojnicz
Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT...
March 31, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28352923/-diagnostic-approach-and-management-of-hypercalcaemia-in-dogs-exemplary-of-primary-hyperparathyroidism
#6
Bianca Désirée Ballhausen, Astrid Wehner, Martin Zöllner, Katrin Hartmann, Stefan Unterer
Hypercalcaemia can be caused by many different diseases. This article summarizes the causes, pathophysiologic mechanisms and diagnostic procedures as well as treatment recommendations. The main focus is on hypercalcaemia in primary hyperparathyroidism (PH), complemented by a case report. An elevated total calcium level should generally be investigated and verified by measurement of ionized calcium concentration. The further diagnostic approach depends on the phosphate level. Tumour screening, measurement of parathormone and parathromone-related protein and sonography of parathyroid glands may be necessary...
March 29, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28346348/vitamin-d-in-chronic-kidney-disease-and-dialysis-patients
#7
REVIEW
Guillaume Jean, Jean Claude Souberbielle, Charles Chazot
Vitamin D deficiency (<20 ng/mL) and insufficiency (20-29 ng/mL) are common among patients with chronic kidney disease (CKD) or undergoing dialysis. In addition to nutritional and sunlight exposure deficits, factors that affect vitamin D deficiency include race, sex, age, obesity and impaired vitamin D synthesis and metabolism. Serum 1,25(OH)₂D levels also decrease progressively because of 25(OH)D deficiency, together with impaired availability of 25(OH)D by renal proximal tubular cells, high fibroblast growth factor (FGF)-23 and decreased functional renal tissue...
March 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28318333/urinary-levels-of-pyridinoline-and-deoxypyridinoline-and-bone-mineral-density-in-children-with-type-1-diabetes-mellitus
#8
Nadide Melike Sav, Mustafa Kendirci, Leyla Akin, Selim Kurtoglu
OBJECTIVE: There is still controversy over the impact of diabetes mellitus (DM) on bone mass in children. Pyridinoline (Pyr) and deoxypyridinoline (DPyr), which stabilize the collagen chains within the extracellular matrix, are known as specific bone turnover markers. The aim of this study was to investigate the relationship between urinary Pyr and DPyr excretions and bone mineral density (BMD) in children with type 1 DM. METHODS: Serum levels of Ca, phosphorus (P), magnesium (Mg), and parathormone (PTH), alkaline phosphatase (ALP) activity, and urinary excretions of Pyr and DPyr were evaluated in 50 diabetic and 130 healthy control subjects aged between 7 and 15 years...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28262264/the-incidence-of-new-onset-diabetes-after-transplantation-and-related-factors-single-center-experience
#9
Ayse Sinangil, Vedat Celik, Soykan Barlas, Yener Koc, Taner Basturk, Tamer Sakaci, Emin Baris Akin, Tevfik Ecder
AIM: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication and is considered a risk factor for patients undergoing renal transplant. The aim of this study was to evaluate the incidence and developing duration of new-onset diabetes after transplant (NODAT) and influencing factors. METHODS: All patients' data was investigated retrospectively. Diabetics, follow-up period<6 months, age<18years were excluded. Demographic, clinical and laboratory data was recorded...
March 2, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28251020/regional-clinical-and-biochemical-differences-among-patients-with-primary-hyperparathyroidism
#10
Özer Makay, Beyza Özçınar, Turgay Şimşek, Cumhur Arıcı, Bülent Güngör, Serdar Özbaş, Tamer Akça, Ali Uğur Emre, Güldeniz Karadeniz Çakmak, Müfide Akçay, Bülent Ünal, Mustafa Girgin, Sadullah Girgin, Semih Görgülü, Atakan Sezer, Adem Karataş, İbrahim Ali Özemir, Nihat Aksakal, Serap Erel, M Ümit Uğurlu, Ali İlker Filiz, Can Atalay, Ali Uzunköy, Uğur Deveci, Çetin Kotan, Gökhan İçöz, Yavuz Kurt, Abut Kebudi, N Zafer Cantürk, Yeşim Erbil, Rumen Pandev, Bahadır M Güllüoğlu
BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. STUDY DESIGN: Retrospective, clinical-based multi-centric study of 694 patients with pHPT. METHODS: Patients from 23 centers and 8 different geographical regions were included...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28243964/associations-of-parathyroid-hormone-levels-and-mineral-parameters-with-heart-rate-variability-in-patients-with-end-stage-renal-disease
#11
Lei Zhang, Shaoyan Yang, Jianling Chen, Jinling Ma, Yueqin Ren
PURPOSE: Parathormone (PTH) is a very potent uraemic toxin, which affects calcium/phosphate homeostasis in patients with end-stage renal disease (ESRD). It also plays the role in uraemic autonomic neuropathy. The aim of the study was to investigate the relationship between elevated PTH levels and cardiac autonomic neuropathy assessed by frequency-domain measures of heart rate variability. METHODS: 24-h ECG was performed in 106 ESRD patients and 65 healthy controls...
February 27, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28217943/fine-needle-cytology-pre-surgical-differentiation-of-parathyroid-neoplasms-is-it-reliable
#12
A Caleo, M Vitale, L Valvano, M Siano, B Angrisani, M Forlenza, A Massari, A Puzziello, F Salzano, P Zeppa
BACKGROUND: Fine needle cytology (FNC) of a parathyroid neoplasia (PN) is reliable, but needs to be confirmed by Parathormone (PTH) and Thyroglobulin (TG) immunoassay on needle washing or by immunocytochemistry (ICC) evaluation. The differentiation between parathyroid adenoma (PA), atypical adenoma (PAA) and carcinoma (PC) is difficult on histology or even impossible on FNC. The aim of this study was to evaluate possible cytological criteria to classify FNC-PN further. METHODS: Twenty-three FNC samples of PN and parathyroid cysts were rather then have been reviewed...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28199935/surgical-management-of-a-giant-parathyroid-adenoma-through-minimal-invasive-parathyroidectomy-a-case-report
#13
Georgios Sahsamanis, Konstantinos Gkouzis, Stavros Samaras, Dionysios Pinialidis, Georgios Dimitrakopoulos
INTRODUCTION: Primary hyperparathyroidism is a common endocrine disorder mostly associated to parathyroid adenomas. Although those tend to be small in size, rare cases of giant parathyroid adenomas may be present. CASE PRESENTATION: A 42year old female was admitted in our department due to weakness and vague abdominal pain for the past 8 months. Preoperative laboratory exams indicated primary hyperparathyroidism as a cause to her symptomatology, with elevated values of parathormone and normal values of serum calcium...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28167381/parathyroid-reimplantation-with-pr-fast-technique-in-unselected-patients-during-thyroidectomy-a-case-series-with-long-term-follow-up-confirming-graft-vitality-and-parathormone-production
#14
Giuseppe Cavallaro, Olga Iorio, Marco Centanni, Lucilla Gargano, Susanna Del Duca, Angela Gurrado, Natale Porta, Vincenzo Petrozza, Mario Testini, Giorgio De Toma
INTRODUCTION: Parathyroid damage or unintentional excision still affect thyroid surgery and may cause permanent hypoparathyroidism. The only way to recover the excised or ischemic gland functionality is still reimplantation. Many sites of reimplantation have been described, each of one showing both advantages and drawbacks. The aim of this study is to verify results of a new procedure called PR-FaST: Parathyroid Reimplantation in Forearm Subcutaneous Tissue, in a series of unselected patients after long-term follow-up...
February 3, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28163524/afebrile-seizures-as-initial-symptom-of-hypocalcemia-secondary-to-hypoparathyroidism
#15
Anastasia Gkampeta, Eftyxia Kouma, Anastasia Touliopoulou, Efstathios Aggelopoulos, Eleni Vourti
Hypocalcemia is rare in childhood and caused, among other conditions, by hypoparathyroidism. DiGeorge syndrome is the most common cause of hypoparathyroidism in childhood. Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. a 7.5-year-old female child presented with afebrile seizures lasting 5 min with postictal drowsiness. A similar episode 1 month ago is described. On admission, a positive Trousseau sign, papilledema, and long QTc on electrocardiography were detected...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28157158/epigenetic-alterations-in-parathyroid-cancers
#16
REVIEW
Chiara Verdelli, Sabrina Corbetta
Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. About 90% of PCas are hormonally active hypersecreting parathormone (PTH); consequently patients present with complications of severe hypercalcemia. Pre-operative diagnosis is often difficult due to clinical features shared with benign parathyroid lesions. Surgery provides the current best chance of cure, though persistent or recurrent disease occurs in about 50% of patients with PCas...
February 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28149023/status-of-serum-calcium-vitamin-d-and-parathyroid-hormone-and-hematological-indices-among-lead-exposed-jewelry-workers-in-dhaka-bangladesh
#17
I Mazumdar, K Goswami, Md Suhrab Ali
Jewelry utilizes lead either directly or as a base metal. Costume jewelry requires lead before molding and plating the product with valuable metals. Therefore, such ornaments have a great potential to release heavy metals having health hazards. Also, jewelry makers engaged in preparing German silver, an alloy, apply lead in smelting, alloying, rolling and milling silver wires and pieces. The metal is taken up by blood, soft tissues and bone. The biological effects of lead are dependent upon the level and duration of exposure...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28145154/effect-of-impaired-ambulation-and-anti-epileptic-drug-intake-on-vitamin-d-status-of-children-with-cerebral-palsy
#18
Anju Seth, Satinder Aneja, Ritu Singh, Ritu Majumdar, Neera Sharma, Muthuselvan Gopinath
BACKGROUND: Children with cerebral palsy (CP) are vulnerable to developing vitamin D deficiency. There is little information on the prevalence and severity of vitamin D deficiency in these patients. OBJECTIVE: To study vitamin D status in children with CP with special reference to their intake of anti-epileptic drugs (AED) and ambulatory status. METHODS: The relative effects of AED use and ambulatory status on the vitamin D status of 120 children with CP aged 2-10 years were examined in this observational study...
February 1, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28112766/factors-influencing-serum-hydroxivitamin-d-levels-and-other-bone-metabolism-parameters-in-healthy-older-women
#19
C Trevisan, N Veronese, L Berton, S Carraro, F Bolzetta, M De Rui, F Miotto, E M Inelmen, A Coin, E Perissinotto, E Manzato, G Sergi
OBJECTIVE: Older women have frequently low serum 25-hydroxivitamin D (25[OH]D) concentrations, high parathormone (PTH) levels and low bone mineral density (BMD) values. Endogenous synthesis, dietary habits, sunlight exposure and fat-mass-mediated storage may influence 25(OH)D levels and bone metabolism, but the relevance of these factors in the elderly has yet to be fully elucidated. We aimed to investigate the influence of dietary vitamin D intake and fat mass on serum 25(OH)D levels and bone metabolism in older women...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28109821/calcium-pyrophosphate-deposition-disease-revealing-a-hypersensitivity-to-vitamin-d
#20
Pauline Baudart, Arnaud Molin, Johann Cesini, Glenville Jones, Martin Kaufmann, Marie Laure Kottler, Christian Marcelli
OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults. METHODS: We describe the first case of a patient presenting a calcium pyrophosphate deposition disease (CPDD) revealing a HVD. RESULTS: An abnormality of phospho-calcic metabolism was discovered during the course of an etiological workup for CPDD in a 52-year-old patient...
January 18, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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