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https://www.readbyqxmd.com/read/28546708/unilateral-exploration-for-parathyroid-adenoma
#1
Maddibande Ramachar Sreevathsa, Khyati Melanta
Between January 2012 to 2016, 20 patients with primary hyperparathyroidism underwent surgical exploration for presumed diagnosis of parathyroid adenoma. Nineteen patients underwent ultrasonography of neck and USG was found to be accurate in localizing the adenoma in 84.2%. Seventeen patients underwent sestamibi isotope scanning and imaging correlated with operative findings in 94.1%. Combined accuracy of ulrasound and sestamibi scan which was done in 17 patients was 95%. Seventeen patients underwent unilateral exploration and there was resolution of disease in 94...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28540883/the-relationship-between-serum-homocysteine-and-highly-sensitive-c-reactive-protein-levels-in-children-on-regular-hemodialysis
#2
Manal Abdel-Salam, Soheir Ibrahim, Shaimaa Abdelmalik Pessar, Eman Al-Morsy
Hyperhomocysteinemia has attracted a lot of attention in renal patients, not only because of its close relationship with renal function but also because it has been implicated as an independent cardiovascular risk factor in these patients. An increased level of C-reactive protein (CRP) has been reported to be a strong predictor of cardiovascular mortality in hemodialysis (HD) patients. The aim of this study was to assess the association between homocysteine (Hcy) and highly sensitive CRP (hsCRP) in cardiovascular risk prediction in children with chronic kidney disease (CKD) on HD...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28516785/measurement-of-intact-parathormone-during-operation-for-primary-hyperparathyroidism
#3
P Libansky, S Adamek, P Broulik, M Fialova, J Kubinyi, J Sedy, P Pafko, D Yershov, R Lischke
In this prospective study, the role of the intact parathormone (iPHT) levels for the verification of pathologic parathyroid tissue removal during parathyroidectomy, was analyzed in 441 patients diagnosed with primary hyperparathyroidism. The level of intact parathormone was obtained before the initial incision (baseline level) and 10 minutes after the pathologic parathyroid gland removal (control value). In 80 % of cases, the decrease of intact parathormone was more than 50 % of the baseline level. The comparison of preoperative and postoperative intact parathormone levels can also be used as marker of parathyroid hyperplasia or persistent hyperparathyroidism...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28504486/high-prevalence-of-vitamin-d-deficiency-among-children-with-chronic-kidney-disease-and-kidney-transplant
#4
Paula Coccia, Juliana Blazquez, Maritza Contreras, Verónica Ferrais, Claudia Raddavero, Lidia Ghezzi, Julio Busaniche, Gonzalo Beneitez, Andrea Kozak, Jorge Ferraris
INTRODUCTION: Vitamin D (25(OH)D) deficiency is common among patients with chronic kidney disease (CKD). Our objective was to establish the prevalence of 25(OH)D deficiency among children with CKD and identify risk factors. A correlation was observed between 25(OH)D and parathormone intact molecule. POPULATION AND METHODS: Cross-sectional study conducted between January 2013 and December 2015. Patients younger than 19 years old with and without CKD were included...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28501573/alterations-of-dna-methylation-in-parathyroid-tumors
#5
REVIEW
Vito Guarnieri, Lucia Anna Muscarella, Chiara Verdelli, Sabrina Corbetta
Parathyroid tumors are common endocrine neoplasias associated with primary hyperparathyroidism, a metabolic disorder characterized by parathormone hypersecretion. Parathyroid neoplasia are frequently benign adenomas or multiple glands hyperplasia, while malignancies are rare. The epigenetic scenario in parathyroid tumors has just begun to be decoded: DNA methylation, histones and chromatin modifiers expression have been investigated so far. The main findings suggest that DNA methylation and chromatin remodeling are active and deregulated in parathyroid tumors, cooperating with genetic alterations to drive the tumor phenotype: the tumor suppressors menin and parafibromin, involved in parathyroid tumorigenesis, interact with chromatin modifiers, defining distinct epigenetic derangements...
May 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28489181/early-postoperative-parathormone-sampling-and-prognosis-after-total-parathyroidectomy-in-secondary-hyperparathyroidism
#6
Climério Pereira do Nascimento, Marília D'Elboux Guimarães Brescia, Melani Ribeiro Custódio, Ledo Mazzei Massoni, André Albuquerque Silveira, Patrícia Taschner Goldenstein, Sérgio Samir Arap, Vanda Jorgetti, Rosa Maria Affonso Moyses, Fábio Luiz de Menezes Montenegro
Introduction: There is possibility of a supernumerary hyperplastic parathyroid gland in dialysis patients after total parathyroidectomy and autograft in dialysis patients. Objective: To test if the early postoperative measure of parathyroid hormone (PTH) can identify persistent hyperparathyroidism. Methods: A prospective cohort of dialysis patients submitted to parathyroidectomy had PTH measured up to one week after operation. The absolute value and the relative decrease were analyzed according to clinical outcome of satisfactory control of secondary hyperparathyroidism or persistence...
April 27, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28486336/seasonal-variations-of-bone-metabolism-and-bone-mineral-density-in-collegiate-alpine-skiers
#7
Teruyuki Sato, Keishoku Sakuraba, Yosuke Tsuchiya, Shinya Maruyama, Eisuke Ochi
This study investigated the seasonal variations in bone metabolism, mineral density, and physical characteristics in collegiate alpine skiers. Twelve male subjects (20.6 ± 1.5 years) were evaluated for body composition, body mineral density (BMD), serum levels of osteocalcin (OC), bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase 5b (TRACP-5b), parathormone, and 25-hydroxyvitamin D (25(OH)D). We also measured the knee extensor and flexor strength, maximal power, and vertical jump. Measurements were conducted in the pre-season period (T1), competitive period (T2), end-of-season period (T3), and resting period (T4)...
May 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28473985/vitamin-d-and-parathyroid-hormone-status-in-female-garment-workers-a-case-control-study-in-bangladesh
#8
Shakil Mahmood, Matiur Rahman, Subrata Kumar Biswas, Shaikh Nazmus Saqueeb, Shiblee Zaman, M Manirujjaman, Rasheda Perveen, Nurshad Ali
Despite the abundant sunlight, vitamin D deficiency is prevalent in South Asian countries including Bangladesh. Information on vitamin D level is insufficient in adults particularly in female garment workers in Bangladesh. This study was designed to evaluate the status of vitamin D, parathormone (PTH), calcium, and alkaline phosphatase (ALP) among the female garment workers in Bangladesh. Blood samples were collected from female garment workers (n = 40, case group) and general female workers (n = 40, control group) in Dhaka...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28465501/preoperative-localization-of-parathyroid-adenoma-in-video-assisted-era-is-better-cervical-ultrasound-or-99mtc-sesta-mibi-scintigraphy
#9
Belinda DE Simone, Paolo Del Rio, Fausto Catena, Gaia Fallani, Cino Bendinelli, Josephine A Napoli, Alberto Zaccaroni, Mario Sianesi
BACKGROUND: Endocrine surgeon localizes solitary adenoma (SA) in preoperative time by cervical ultrasound (c-US) and/or 99mTC Sesta MIBI scintigraphy (MIBI-S), but in clinical practice they often show discordant results. The aim of our study is to verify if c-US and MIBI-S have different sensitivity in preoperative localization of SA, depending on its localization, in planning minimally-invasive video-assisted parathyroidectomy (MIVAP). METHODS: This is a retrospective analysis of data (demographics data, preoperative localization of SA by US and MIBI-S, presence of associated thyroid disease, preoperative calcemia, preoperative serum PTH, surgical time, intraoperative PTH values, day 1 postoperative calcemia, definitive histological report) about patients consecutively submitted to MIVAP because of SA between January 2011 and January 2014 in the department of endocrine and general surgery of the University Hospital of Parma (Italy)...
May 2, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28452813/duodenal-histopathology-and-laboratory-deficiencies-related-to-bone-metabolism-in-coeliac-disease
#10
Lotte Posthumus, Abdul Al-Toma
OBJECTIVES: Coeliac disease (CD) is a chronic immune-mediated small intestine enteropathy precipitated by gluten in genetically predisposed individuals. Adult presentation is often atypical and malabsorption of vitamins and minerals is common, with a consequent disturbance of bone metabolism. We aim to evaluate laboratory deficiencies related to bone metabolism and the relationship between severity of histological damage and degree of bone mass loss at diagnosis of CD. MATERIALS AND METHODS: A retrospective cross-sectional study of 176 adult coeliac patients was carried out...
April 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28442834/parathyroidectomy-decreases-insulin-resistance-index-in-patients-with-primary-hyperparathyroidism
#11
Cevdet Duran, Barıs Sevinc, Orkide Kutlu, Omer Karahan
Primary hyperparathyroidism (PHPT) has been considered a cause of insulin resistance (IR) and impaired glucose metabolism. However, there are conflicting results related with the recovery of insulin resistance in patients with PHPT following curative parathyroidectomy. Our aim is to evaluate the effects of curative parathyroidectomy on IR in patients with PHPT. This is a prospective interventional study. Twenty-one consecutive patients with symptomatic PHPT were included into the study. All patients underwent parathyroidectomy...
April 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28431568/a-case-report-of-severe-calciphylaxis-suggested-approach-for-diagnosis-and-treatment
#12
Margret Patecki, Gabriele Lehmann, Jan Hinrich Bräsen, Jessica Schmitz, Anna Bertram, Lars Daniel Berthold, Hermann Haller, Wilfried Gwinner
BACKGROUND: Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. We report a case which clearly illustrates that knowledge of the underlying bone disorder is essential for a directed treatment. Based on this experience we discuss a systematic diagnostic and therapeutic approach in patients with calciphylaxis...
April 21, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28424141/can-parathormon-levels-after-ipsilateral-lobectomy-predict-postoperative-hypocalcemia-in-patients-undergoing-total-thyroidectomy
#13
Fatih Kul, Turkay Kirdak, Pinar Sarkut, Gokhan Ocakoglu, Nusret Korun
The purpose of this study was to investigate the relationship between the serum parathormone (PTH) levels measured after completion of hemithyroidectomy on the first side during total thyroidectomy and the postoperative hypocalcemia. The patients were divided into two groups, as those who demonstrated a decrease in PTH levels measured after completion of hemithyroidectomy of the first side (Group 1, n = 43) and those who did not demonstrate a decrease in PTH levels (Group 2, n = 24). The serum PTH levels were measured just before the incision (PTHi), when the hemithyroidectomy stage had been completed (PTHht), at the end of the operation (PTHtt), and at the postoperative 24th hour (PTH24hr)...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28416255/differences-between-2nd-and-3rd-generation-seric-parathormone-determination-methods-on-mortality-in-haemodialysis-patients
#14
Laura Rodríguez-Osorio, Concepción de la Piedra, Mercedes Rubert, Marta Martín-Fernández, María Luisa González Casaus, Carolina Gracia-Iguacel, Jesús Egido, Ricardo Villa-Bellosta, Emilio González Parra
Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). OBJECTIVE: To evaluate the differences in mortality of dialysis patients between both assays to measure PTH, as well as the possible prognostic role of the PTHbio/iPTH ratio. METHODS: 145 haemodialysis patients were included with 2-year monitoring including baseline laboratory test and annually thereafter...
April 14, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28396941/effect-of-the-timing-of-dialysis-initiation-on-left-ventricular-hypertrophy-and-%C3%A4-nflammation-in-pediatric-patients
#15
Sevcan A Bakkaloğlu, Yaşar Kandur, Erkin Serdaroğlu, Aytül Noyan, Aysun Karabay Bayazıt, Lale Sever, Sare Gülfem Özlü, Gül Özçelik, İsmail Dursun, Caner Alparslan
BACKGROUND: The optimal time for dialysis initiation in adults and children with chronic kidney disease remains unclear. The aim of this study was to evaluate the impact of dialysis timing on different outcome parameters, in particular left ventricular (LV) morphology and inflammation, in pediatric patients receiving peritoneal dialysis and hemodialysis. METHODS: The medical records of pediatric dialysis patients who were followed-up in nine pediatric nephrology centers in Turkey between 2008 and 2013 were retrospectively reviewed...
April 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28362510/apoptosis-in-primary-hyperparathyroidism
#16
Oliwia Anna Segiet, Łukasz Mielańczyk, Adam Piecuch, Marek Michalski, Szczepan Tyczyński, Marlena Brzozowa-Zasada, Mariusz Deska, Romuald Wojnicz
Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT...
March 31, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28352923/-diagnostic-approach-and-management-of-hypercalcaemia-in-dogs-exemplary-of-primary-hyperparathyroidism
#17
Bianca Désirée Ballhausen, Astrid Wehner, Martin Zöllner, Katrin Hartmann, Stefan Unterer
Hypercalcaemia can be caused by many different diseases. This article summarizes the causes, pathophysiologic mechanisms and diagnostic procedures as well as treatment recommendations. The main focus is on hypercalcaemia in primary hyperparathyroidism (PH), complemented by a case report. An elevated total calcium level should generally be investigated and verified by measurement of ionized calcium concentration. The further diagnostic approach depends on the phosphate level. Tumour screening, measurement of parathormone and parathromone-related protein and sonography of parathyroid glands may be necessary...
March 29, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28346348/vitamin-d-in-chronic-kidney-disease-and-dialysis-patients
#18
REVIEW
Guillaume Jean, Jean Claude Souberbielle, Charles Chazot
Vitamin D deficiency (<20 ng/mL) and insufficiency (20-29 ng/mL) are common among patients with chronic kidney disease (CKD) or undergoing dialysis. In addition to nutritional and sunlight exposure deficits, factors that affect vitamin D deficiency include race, sex, age, obesity and impaired vitamin D synthesis and metabolism. Serum 1,25(OH)₂D levels also decrease progressively because of 25(OH)D deficiency, together with impaired availability of 25(OH)D by renal proximal tubular cells, high fibroblast growth factor (FGF)-23 and decreased functional renal tissue...
March 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28318333/urinary-levels-of-pyridinoline-and-deoxypyridinoline-and-bone-mineral-density-in-children-with-type-1-diabetes-mellitus
#19
Nadide Melike Sav, Mustafa Kendirci, Leyla Akin, Selim Kurtoglu
OBJECTIVE: There is still controversy over the impact of diabetes mellitus (DM) on bone mass in children. Pyridinoline (Pyr) and deoxypyridinoline (DPyr), which stabilize the collagen chains within the extracellular matrix, are known as specific bone turnover markers. The aim of this study was to investigate the relationship between urinary Pyr and DPyr excretions and bone mineral density (BMD) in children with type 1 DM. METHODS: Serum levels of Ca, phosphorus (P), magnesium (Mg), and parathormone (PTH), alkaline phosphatase (ALP) activity, and urinary excretions of Pyr and DPyr were evaluated in 50 diabetic and 130 healthy control subjects aged between 7 and 15 years...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28262264/the-incidence-of-new-onset-diabetes-after-transplantation-and-related-factors-single-center-experience
#20
Ayse Sinangil, Vedat Celik, Soykan Barlas, Yener Koc, Taner Basturk, Tamer Sakaci, Emin Baris Akin, Tevfik Ecder
AIM: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication and is considered a risk factor for patients undergoing renal transplant. The aim of this study was to evaluate the incidence and developing duration of new-onset diabetes after transplant (NODAT) and influencing factors. METHODS: All patients' data was investigated retrospectively. Diabetics, follow-up period<6 months, age<18years were excluded. Demographic, clinical and laboratory data was recorded...
March 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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