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Dawn Nilsen

Kimberly Hreha, Glen Gillen, Natalia Noce, Dawn Nilsen
Background Strokes resulting in cognitive and motor problems can be debilitating and prolong recovery. Risk of a second stroke occurs for 40% of all first-time stroke survivors within five years. Prism adaptation treatment (PAT) may simultaneously improve functions of both spatial and motor systems. This has not been studied with a cohort comprised of multiple strokes nor measured change using specific motor outcomes. Objectives To determine the feasibility and effectiveness of using PAT to improve spatial and motor functions in stroke survivors with multiple strokes...
May 2018: Topics in Stroke Rehabilitation
Jorge Guerra, Jasim Uddin, Dawn Nilsen, James Mclnerney, Ammarah Fadoo, Isirame B Omofuma, Shatif Hughes, Sunil Agrawal, Peter Allen, Heidi M Schambra
There currently exist no practical tools to identify functional movements in the upper extremities (UEs). This absence has limited the precise therapeutic dosing of patients recovering from stroke. In this proof-of-principle study, we aimed to develop an accurate approach for classifying UE functional movement primitives, which comprise functional movements. Data were generated from inertial measurement units (IMUs) placed on upper body segments of older healthy individuals and chronic stroke patients. Subjects performed activities commonly trained during rehabilitation after stroke...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
Bonnie R Joubert, Janine F Felix, Paul Yousefi, Kelly M Bakulski, Allan C Just, Carrie Breton, Sarah E Reese, Christina A Markunas, Rebecca C Richmond, Cheng-Jian Xu, Leanne K Küpers, Sam S Oh, Cathrine Hoyo, Olena Gruzieva, Cilla Söderhäll, Lucas A Salas, Nour Baïz, Hongmei Zhang, Johanna Lepeule, Carlos Ruiz, Symen Ligthart, Tianyuan Wang, Jack A Taylor, Liesbeth Duijts, Gemma C Sharp, Soesma A Jankipersadsing, Roy M Nilsen, Ahmad Vaez, M Daniele Fallin, Donglei Hu, Augusto A Litonjua, Bernard F Fuemmeler, Karen Huen, Juha Kere, Inger Kull, Monica Cheng Munthe-Kaas, Ulrike Gehring, Mariona Bustamante, Marie José Saurel-Coubizolles, Bilal M Quraishi, Jie Ren, Jörg Tost, Juan R Gonzalez, Marjolein J Peters, Siri E Håberg, Zongli Xu, Joyce B van Meurs, Tom R Gaunt, Marjan Kerkhof, Eva Corpeleijn, Andrew P Feinberg, Celeste Eng, Andrea A Baccarelli, Sara E Benjamin Neelon, Asa Bradman, Simon Kebede Merid, Anna Bergström, Zdenko Herceg, Hector Hernandez-Vargas, Bert Brunekreef, Mariona Pinart, Barbara Heude, Susan Ewart, Jin Yao, Nathanaël Lemonnier, Oscar H Franco, Michael C Wu, Albert Hofman, Wendy McArdle, Pieter Van der Vlies, Fahimeh Falahi, Matthew W Gillman, Lisa F Barcellos, Ashish Kumar, Magnus Wickman, Stefano Guerra, Marie-Aline Charles, John Holloway, Charles Auffray, Henning W Tiemeier, George Davey Smith, Dirkje Postma, Marie-France Hivert, Brenda Eskenazi, Martine Vrijheid, Hasan Arshad, Josep M Antó, Abbas Dehghan, Wilfried Karmaus, Isabella Annesi-Maesano, Jordi Sunyer, Akram Ghantous, Göran Pershagen, Nina Holland, Susan K Murphy, Dawn L DeMeo, Esteban G Burchard, Christine Ladd-Acosta, Harold Snieder, Wenche Nystad, Gerard H Koppelman, Caroline L Relton, Vincent W V Jaddoe, Allen Wilcox, Erik Melén, Stephanie J London
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip...
April 7, 2016: American Journal of Human Genetics
Michael J Stirratt, Jacqueline Dunbar-Jacob, Heidi M Crane, Jane M Simoni, Susan Czajkowski, Marisa E Hilliard, James E Aikens, Christine M Hunter, Dawn I Velligan, Kristen Huntley, Gbenga Ogedegbe, Cynthia S Rand, Eleanor Schron, Wendy J Nilsen
Medication adherence plays an important role in optimizing the outcomes of many treatment and preventive regimens in chronic illness. Self-report is the most common method for assessing adherence behavior in research and clinical care, but there are questions about its validity and precision. The NIH Adherence Network assembled a panel of adherence research experts working across various chronic illnesses to review self-report medication adherence measures and research on their validity. Self-report medication adherence measures vary substantially in their question phrasing, recall periods, and response items...
December 2015: Translational Behavioral Medicine
Cheryl Bushnell, Janet Prvu Bettger, Kevin M Cockroft, Steven C Cramer, Maria Orlando Edelen, Daniel Hanley, Irene L Katzan, Soeren Mattke, Dawn M Nilsen, Tepring Piquado, Elizabeth R Skidmore, Kay Wing, Gayane Yenokyan
BACKGROUND: About half of survivors with stroke experience severe and significant long-term disability. The purpose of this article is to review the state of the science and to make recommendations for measuring patient-centric outcomes in interventions for motor improvement in the chronic stroke phase. METHODS AND RESULTS: A 9-member expert panel reviewed evidence to identify measures of upper and lower extremity function used to date as outcomes in trials with patients who experienced a stroke ≥6 months before assessment...
October 2015: Circulation. Cardiovascular Quality and Outcomes
Dawn Nilsen, Glen Gillen, Marian Arbesman, Deborah Lieberman
Evidence Connection articles provide a clinical application of systematic reviews developed in conjunction with the American Occupational Therapy Association's (AOTA's) Evidence-Based Practice project. The clinical condition discussed in this inaugural Evidence Connection article is adults with stroke. Findings from the systematic reviews on this topic were published in the January/February 2015 issue of the American Journal of Occupational Therapy and in AOTA's Occupational Therapy Practice Guidelines for Adults With Stroke (Wolf & Nilsen, 2015)...
September 2015: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Elizabeth Coker, Tara L McIsaac, Dawn Nilsen
Elite dancers often engage in mental practice during training, but little is known about the effects of discrete, repetitive motor imagery on dance movement performance. This study compared the effects of two motor imagery modalities, third-person visual imagery and kinesthetic imagery, on hip and pelvis kinematics during two technical dance movements, plié and sauté. Twenty-four female dancers (mean age: 26.04; mean years of training: 19.63) were randomly assigned to a type of imagery practice: visual imagery (VI), kinesthetic imagery (KI), or a mental arithmetic task control condition (MAT)...
June 2015: Journal of Dance Medicine & Science
Glen Gillen, Dawn M Nilsen, Jessica Attridge, Erasmia Banakos, Marie Morgan, Lauren Winterbottom, Wesley York
This evidence-based review was conducted to determine which interventions are effective in improving occupational performance after stroke. Forty-six articles met the inclusion criteria and were examined. Interventions for the following impairments were reviewed: general cognitive deficits, executive dysfunction, apraxia, memory loss, attention deficits, visual field deficits (included because of their close relationship with neglect), and unilateral neglect. Evidence is available from a variety of clinical trials to guide interventions regarding general cognition, apraxia, and neglect...
January 2015: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Dawn M Nilsen, Glen Gillen, Daniel Geller, Kimberly Hreha, Ellen Osei, Ghazala T Saleem
We conducted a review to determine the effectiveness of interventions to improve occupational performance in people with motor impairments after stroke as part of the American Occupational Therapy Association's Evidence-Based Practice Project. One hundred forty-nine studies met inclusion criteria. Findings related to key outcomes from select interventions are presented. Results suggest that a variety of effective interventions are available to improve occupational performance after stroke. Evidence suggests that repetitive task practice, constraint-induced or modified constraint-induced movement therapy, strengthening and exercise, mental practice, virtual reality, mirror therapy, and action observation can improve upper-extremity function, balance and mobility, and/or activity and participation...
January 2015: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Dawn M Nilsen, Glen Gillen, Theresa DiRusso, Andrew M Gordon
OBJECTIVE: This preliminary study sought to determine whether the imagery perspective used during mental practice (MP) differentially influenced performance outcomes after stroke. METHOD: Nineteen participants with unilateral subacute stroke (9 men and 10 women, ages 28-77) were randomly allocated to one of three groups. All groups received 30-min occupational therapy sessions 2×/wk for 6 wk. Experimental groups received MP training in functional tasks using either an internal or an external perspective; the control group received relaxation imagery training...
May 2012: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Elizabeth Coker Girón, Tara McIsaac, Dawn Nilsen
Motor imagery is a type of mental practice that involves imagining the body performing a movement in the absence of motor output. Dance training traditionally incorporates mental practice techniques, but quantitative effects of motor imagery on the performance of dance movements are largely unknown. This pilot study compared the effects of two different imagery modalities, external visual imagery and kinesthetic imagery, on pelvis and hip kinematics during two technical dance movements, plié and sauté. Each of three female dance students (mean age = 19...
March 2012: Journal of Dance Medicine & Science
Dawn M Nilsen, Glen Gillen, Andrew M Gordon
OBJECTIVE: We sought to determine whether mental practice is an effective intervention to improve upper-limb recovery after stroke. METHOD: We conducted a systematic review of the literature, searching electronic databases for the years 1985 to February 2009. We selected studies according to specified criteria, rated each study for level of evidence, and summarized study elements. RESULTS: Studies differed with respect to design, patient characteristics, intervention protocols, and outcome measures...
September 2010: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Bert Steenbergen, Céline Crajé, Dawn M Nilsen, Andrew M Gordon
Converging evidence indicates that motor deficits in cerebral palsy (CP) are related not only to problems with execution, but also to impaired motor planning. Current rehabilitation mainly focuses on alleviating compromised motor execution. Motor imagery is a promising method of training the more 'cognitive' aspects of motor behaviour, and may, therefore, be effective in facilitating motor planning in patients with CP. In this review first we present the specific motor planning problems in CP followed by a discussion of motor imagery and its use in clinical practice...
September 2009: Developmental Medicine and Child Neurology
Dawn M Nilsen, Terry R Kaminski, Andrew M Gordon
OBJECTIVE: Upper limb retraining during the early phases of neurological rehabilitation often involves having individuals practice reaching in body orientations that reduce the effect of gravity on various joint motions (e.g., shoulder flexion, elbow extension). However, the efficacy of these training techniques has not been determined. The purpose of this study was to determine the effects of reducing gravity through a change in body orientation from sitting to side-lying on the kinematics of a point-to-point movement in healthy elderly persons...
January 2003: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
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