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https://www.readbyqxmd.com/read/27903511/cardiac-remodeling-and-increased-central-venous-pressure-underlie-elevated-stroke-volume-and-cardiac-output-of-seawater-acclimated-rainbow-trout
#1
Jeroen Brijs, Erik Sandblom, Esmée Dekens, Joacim Näslund, Andreas Ekström, Michael Axelsson
Substantial increases in cardiac output (CO), stroke volume (SV) and gastrointestinal blood flow are essential for euryhaline rainbow trout (Oncorhyncus mykiss) osmoregulating in seawater. However, the underlying hemodynamic mechanisms responsible for these changes are unknown. By examining a range of circulatory and cardiac morphological variables of seawater- and freshwater-acclimated rainbow trout, the present study revealed a significantly higher central venous pressure (CVP) in seawater-acclimated trout (~0...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27794544/hsp70-expression-induced-by-co-enzyme-q10-protected-chicken-myocardial-cells-from-damage-and-apoptosis-under-in-vitro-heat-stress
#2
J Xu, S Tang, E Song, B Yin, D Wu, E Bao
The aim of this study was to investigate whether induction of Hsp70 expression by co-enzyme Q10 (Q10) treatment protects chicken primary myocardial cells (CPMCs) from damage and apoptosis in response to heat stress for 5 hours. Analysis of the expression and distribution of Hsp70 and the levels of the damage-related enzymes creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), as well as pathological analysis showed that co-enzyme Q10 alleviated the damage caused to CPMCs during heat stress. Further, analysis of cell apoptosis and the expression of cleaved caspase-3 indicated that co-enzyme Q10 did have an anti-apoptotic role during heat stress...
October 28, 2016: Poultry Science
https://www.readbyqxmd.com/read/27677262/self-nanoemulsifying-drug-delivery-system-of-coenzyme-q10-with-improved-dissolution-bioavailability-and-protective-efficiency-on-liver-fibrosis
#3
Abeer Khattab, Lobna Hassanin, Nashwah Zaki
The aim of our investigation is to develop and characterize self-nanoemulsifying drug delivery systems (SNEDDS) of CoQ10 to improve its water solubility, dissolution rate, and bioavailability, and then evaluate its biochemical and physiological effect on liver cirrhosis in rats compared with CoQ10 powder. SNEDDS are isotropic and thermodynamically stable mixture of oil, surfactant, co-surfactant, and drug that form an oil/water nanoemulsion when added to aqueous phases with soft agitation. Upon administration, self-nanoemulsifying system becomes in contact with gastrointestinal fluid and forms o/w nanoemulsion by the aid of gastrointestinal motility...
September 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27630504/comparative-evaluation-of-co-enzyme-q10-and-melaleuca-alternifolia-as-antioxidant-gels-in-treatment-of-chronic-periodontitis-a-clinical-study
#4
Chetan Purushottam Raut, Kunal S Sethi
BACKGROUND: Conventional nonsurgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Coenzyme Q10 and tea tree oil (TTO) are known to have potential therapeutic benefits in chronic periodontitis. AIMS: The aim of the study is to compare the efficacy of Coenzyme Q10 (Perio Q(®)) and tea tree oil (Melaleuca alternifolia) gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis...
July 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27572719/pharmacological-treatments-for-friedreich-ataxia
#5
REVIEW
Mary Kearney, Richard W Orrell, Michael Fahey, Ruth Brassington, Massimo Pandolfo
BACKGROUND: Friedreich ataxia is a rare inherited autosomal recessive neurological disorder, characterised initially by unsteadiness in standing and walking, slowly progressing to wheelchair dependency usually in the late teens or early twenties. It is associated with slurred speech, scoliosis, and pes cavus. Heart abnormalities cause premature death in 60% of people with the disorder. There is no easily defined clinical or biochemical marker and no known treatment. This is the second update of a review first published in 2009 and previously updated in 2012...
August 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27544369/effect-of-coenzyme-q10-supplementation-on-diabetes-biomarkers-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#6
Maedeh Moradi, Fahimeh Haghighatdoost, Awat Feizi, Bagher Larijani, Leila Azadbakht
BACKGROUND: Several studies have investigated the effect of Co-Q10 on diabetes biomarkers, but findings are inconsistent. This systematic review and meta-analysis of clinical trials was conducted to summarize the effect of Co-Q10 supplementation on diabetes biomarkers. METHODS: We searched Pubmed, EMBASE, Science direct, ISI web of science, and Google Scholar for randomized controlled trials from 1989 until March 2016. We included randomized controlled trials reporting fasting blood glucose (FBG), fasting insulin and HbA1c...
August 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27503149/a-sex-difference-in-oxidative-stress-and-behavioral-suppression-induced-by-ethanol-withdrawal-in-rats
#7
Marianna E Jung, Daniel B Metzger
Ethanol withdrawal (EW) is referred to the abrupt termination of long-term heavy drinking, and provokes oxidative brain damage. Here, we investigated whether the cerebellum and hippocampus of female rats are less affected by prooxidant EW than male rats due to the antioxidant effect of 17β-estradiol (E2). Female and male rats received a four-week ethanol diet and three-week withdrawal per cycle for two cycles. Some female rats were ovariectomized with E2 or antioxidant (Vitamin E+Co-Q10) treatment. Measurements were cerebellum (Rotarod) and hippocampus (water-maze)-related behaviors, oxidative markers (O2(-), malondialdehyde, protein carbonyls), mitochondrial membrane swelling, and a key mitochondrial enzyme, cytochrome c oxidase (CcO)...
November 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27432748/obesity-induced-oocyte-mitochondrial-defects-are-partially-prevented-and-rescued-by-supplementation-with-co-enzyme-q10-in-a-mouse-model
#8
C E Boots, A Boudoures, W Zhang, A Drury, K H Moley
STUDY QUESTION: Does supplementation with co-enzyme Q10 (CoQ10) improve the oocyte mitochondrial abnormalities associated with obesity in mice? SUMMARY ANSWER: In an obese mouse model, CoQ10 improves the mitochondrial function of oocytes. WHAT IS KNOWN ALREADY: Obesity impairs oocyte quality. Oocytes from mice fed a high-fat/high-sugar (HF/HS) diet have abnormalities in mitochondrial distribution and function and in meiotic progression. STUDY DESIGN, SIZE, DURATION: Mice were randomly assigned to a normal, chow diet or an isocaloric HF/HS diet for 12 weeks...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27374290/is-coenzyme-q10-effective-in-protection-against-ulcerative-colitis-an-experimental-study-in-rats
#9
Mohamed Gamal Ewees, Basim Anwar Shehata Messiha, Ali Ahmed Abo-Saif, Hekma Abd El-Tawab Abd El-Latif
Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10 appear most promising for a variety of diseases, including ulcerative colitis (UC). The present investigation aims to elucidate the possible protective effects of Co-Q10 against UC, as induced by the administration of iodoacetamide to adult male albino rats...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27345130/elucidation-of-the-mechanism-of-atorvastatin-induced-myopathy-in-a-rat-model
#10
Samar O El-Ganainy, Ahmed El-Mallah, Dina Abdallah, Mahmoud M Khattab, Mahmoud M Mohy El-Din, Aiman S El-Khatib
Myopathy is among the well documented and the most disturbing adverse effects of statins. The underlying mechanism is still unknown. Mitochondrial dysfunction related to coenzyme Q10 decline is one of the proposed theories. The present study aimed to investigate the mechanism of atorvastatin-induced myopathy in rats. In addition, the mechanism of the coenzyme Q10 protection was investigated with special focus of mitochondrial alterations. Sprague-Dawely rats were treated orally either with atorvastatin (100mg/kg) or atorvastatin and coenzyme Q10 (100mg/kg)...
June 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27340342/cardiorenal-involvement-in-metabolic-syndrome-induced-by-cola-drinking-in-rats-proinflammatory-cytokines-and-impaired-antioxidative-protection
#11
Matilde Otero-Losada, Hernán Gómez Llambí, Graciela Ottaviano, Gabriel Cao, Angélica Müller, Francisco Azzato, Giuseppe Ambrosio, José Milei
We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. Male Wistar rats drank ad libitum regular cola (C, n = 12) or tap water (W, n = 12). Measures. Body weight, nutritional data, plasma glucose, cholesterol fractions, TG, urea, creatinine, coenzyme Q10, SBP, and echocardiograms (0 mo and 6 mo). At 6 months euthanasia was performed. Kidneys were processed for histopathology and immunohistochemistry (semiquantitative)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27333901/coenzyme-q10-and-utility-in-heart-failure-just-another-supplement
#12
REVIEW
Sylvia Oleck, Hector O Ventura
Heart failure affects 5.1 million people in the USA annually. It accounts for a frequent cause of hospitalizations and disability. Patients with congestive heart failure have lower plasma levels of CoQ10, which is an independent predictor of mortality in this patient population. It has been hypothesized that a deficiency of CoQ10 can play a role in the development and worsening of heart failure, and that oral supplementation can possibly improve symptoms and survival in these patients. Based on previous small studies and meta-analyses, the use of CoQ10 in heart failure suggested an improvement ejection fraction, stroke volume, cardiac output, and cardiac index with CoQ10 supplementation, however most of these small studies appeared to be underpowered to result in any significant data...
August 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/27175889/purification-and-characterization-of-the-carbonic-anhydrase-enzyme-from-black-sea-trout-salmo-trutta-labrax-coruhensis-kidney-and-inhibition-effects-of-some-metal-ions-on-enzyme-activity
#13
Murat Kucuk, İlhami Gulcin
In this study, the carbonic anhydrase (CA) enzyme was purified from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney with a specific activity of 603.77EU/mg and a yield of 35.5% using Sepharose-4B-l-tyrosine- sulphanilamide affinity column chromatography. For determining the enzyme purity and subunit molecular mass, sodiumdodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) was performed and single band was observed. The molecular mass of subunit was found approximately 29.71kDa. The optimum temperature, activation energy (Ea), activation enthalpy (ΔH) and Q10 values were obtained from Arrhenius plot...
June 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27136895/repurposing-atovaquone-targeting-mitochondrial-complex-iii-and-oxphos-to-eradicate-cancer-stem-cells
#14
Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of pneumocystis pneumonia (PCP) and/or toxoplasmosis in immune-compromised patients. Atovaquone is a hydroxy-1,4-naphthoquinone analogue of ubiquinone, also known as Co-enzyme Q10 (CoQ10). It is a well-tolerated drug that does not cause myelo-suppression. Mechanistically, it is thought to act as a potent and selective OXPHOS inhibitor, by targeting the CoQ10-dependence of mitochondrial complex III...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27087047/protective-effect-of-co-enzyme-q10-on-doxorubicin-induced-cardiomyopathy-of-rat-hearts
#15
Pei-Yu Chen, Chien-Wen Hou, Marthandam Asokan Shibu, Cecilia Hsuan Day, Peiying Pai, Zhao-Rong Liu, Tze-Yi Lin, Vijaya Padma Viswanadha, Chia-Hua Kuo, Chih-Yang Huang
Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day...
April 18, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27047809/effects-of-coenzyme-q10-supplementation-on-c-reactive-protein-and-homocysteine-as-the-inflammatory-markers-in-hemodialysis-patients-a-randomized-clinical-trial
#16
Narges-Sadat Zahed, Maryam Ghassami, Hajar Nikbakht
BACKGROUND: The most leading cause of death in end-stage renal disease (ESRD) patients are cardiovascular disease and inflammatory markers are related to coronary events. CO-Q10 (coenzyme Q10) is a protective supplement from free radical oxidative damage. In addition, hyperhomocysteinemia is an independent coronary artery disease (CAD) risk factor. OBJECTIVES: Due to increasing oxidative stress in dialysis patients, and the effect of CO-Q10 in decrease oxidative stress, in this work, we assessed the effect of CO-Q10 on C-reactive protein (CRP) level as an inflammatory marker and homocysteine in dialysis patients...
January 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27038957/functional-food-red-yeast-rice-ryr-for-metabolic-syndrome-amelioration-a-review-on-pros-and-cons
#17
REVIEW
Seema Patel
Red yeast rice (RYR), the fermentation product of mold Monascus purpureus has been an integral part of Oriental food and traditional Chinese medicine, long before the discovery of their medicinal roles. With the identification of bioactive components as polyketide pigments (statins), and unsaturated fatty acids, RYR has gained a nutraceutical status. Hypercholesterolemic effect of this fermented compound has been validated and monacolin K has been recognized as the pivotal component in cholesterol alleviation...
May 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27010352/p-coumaric-acid-a-novel-and-effective-biomarker-for-quantifying-hypoxic-stress-by-hilic-esi-ms
#18
Yuliya E Silina, Claudia Fink-Straube, Rainer G Hanselmann, Henrike Peuschel, Dietrich A Volmer
In this study, we report p-coumaric acid as novel and effective response marker for indirectly measuring the levels of hypoxia in normal primary bronchial epithelial cells. We developed a simple and rapid technique based on hydrophilic interaction chromatography-electrospray ionization-mass spectrometry (HILIC-ESI-MS). During 168h of hypoxia without induction of reactive oxygen species (ROS), an almost linear increase of p-coumaric acid levels was observed. We interpret the increasing p-coumaric acid concentrations during hypoxia as a result of cell damage, triggered by reduced co-enzyme Q10 levels, because the oxidative cascade was not able to supply sufficient energy...
May 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26935953/sigmoid-volvulus-in-a-patient-with-mitochondrial-encephalomyopathy-lactic-acidosis-and-stroke-like-episodes-melas-a-rare-occurrence
#19
Alexander Hallac, Hari B Keshava, Gareth Morris-Stiff, Samuel Ibrahim
Mitochondrial diseases are rare and devastating, with a wide spectrum of clinical presentations and systemic symptoms. The majority of the published literature focuses on the neuromuscular manifestations and genetic components of this mitochondrial cytopathy, however, cardiac, renal, endocrine and gastrointestinal manifestations may also be present. The authors report a case detailing a 56-year-old woman's final hospitalisation from the gastrointestinal sequelae of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) (Co Q10 deficiency variant)...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26918065/a-summary-of-a-cochrane-review-co-enzyme-q10-supplements-to-prevent-cardiovascular-disease
#20
Nancy Santesso
No abstract text is available yet for this article.
October 1, 2015: European Journal of Integrative Medicine
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