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https://www.readbyqxmd.com/read/29653419/a-sensitive-signal-on-photoelectrochemical-sensor-for-tetracycline-determination-using-visible-light-driven-flower-like-cn-biobr-composites
#1
Pengcheng Yan, Desheng Jiang, Yuhui Tian, Li Xu, Junchao Qian, Henan Li, Jiexiang Xia, Huaming Li
As a broad-spectrum antibiotic, tetracycline (TC) is widely used in agricultural purposes and human therapy. More attention is paid to TC as a serious threat to human health, including the fast spreading of antibiotic resistance gene and the serious toxicity to aquatic organisms. Therefore, the timely and accurate determination of TC residues is an urgent task to protect the safety of human. Herein, an effective and facile photoelectrochemical sensor platform based on carbon nitride/bismuth oxyhalide (CN/BiOBr) composites can be constructed for monitoring TC...
March 24, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29623214/mandibular-osteomyelitis-due-to-raoultella-species
#2
Philip W Lam, Manal Tadros, Ignatius W Fong
Introduction: Raoultella is a genus of aerobic Gram-negative bacilli belonging to the family Enterobacteriaceae that are commonly found in water, soil and aquatic environments. With improved bacterial identification techniques, Raoultella species (namely R. planticola and R. ornithinolytica ) have been an increasingly reported cause of infections in humans. Case presentation: An 85-year-old man presented to hospital with a several-week history of left jaw pain and trismus...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29553267/speciation-of-phenanthriplatin-and-its-analogs-in-the-core-of-tobacco-mosaic-virus
#3
Amit A Vernekar, Gilles Berger, Anna E Czapar, Frank A Veliz, David I Wang, Nicole F Steinmetz, Stephen J Lippard
Efficient loading of drugs in novel delivery agents has the potential to substantially improve therapy by targeting the diseased tissue while avoiding unwanted side effects. Here we report the first systematic study of the loading mechanism of phenanthriplatin and its analogs into tobacco mosaic virus (TMV), previously used by our group as an efficient carrier for anticancer drug delivery. A detailed investigation of the preferential uptake of phenanthriplatin in its aquated form (∼2000 molecules per TMV particle versus ∼1000 for the chlorido form) is provided...
March 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29540296/cytokine-modulation-in-response-to-acute-and-chronic-aquatic-therapy-intervention-in-parkinson-disease-individuals-a-pilot-study
#4
Daniela Pochmann, Pâmela Krause Peccin, Ivy Reichert Vital da Silva, Gilson Pires Dorneles, Alessandra Peres, Simone Nique, Vera Striebel, Viviane Rostirola Elsner
The study aimed to compare the basal plasma levels of inflammatory markers (MCP-1, IL-1ra and IL-1β) in Parkinson Disease group (PDG) with control healthy subjects (control group, CG), as well to investigate the acute and chronic effects of an aquatic physiotherapy program on these biomarkers in PDG. Firstly, a rest blood sampling was taken from antecubital vein of the PD and CG. After, the PD individuals were submitted to a supervisioned aquatic physiotherapy program during 1 month, twice a week (60 min/session)...
March 11, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29533252/the-effects-of-a-motorized-aquatic-treadmill-exercise-program-on-muscle-strength-cardiorespiratory-fitness-and-clinical-function-in-subacute-stroke-patients-a-randomized-controlled-pilot-trial
#5
So Young Lee, Eun Young Han, Bo Ryun Kim, Sang Hee Im
OBJECTIVE: The aim of this study was to assess the effects of a motorized aquatic treadmill exercise program improve the isometric strength of the knee muscles, cardiorespiratory fitness, arterial stiffness, motor function, balance, functional outcomes and quality of life in subacute stroke patients. DESIGN: Thirty-two patients were randomly assigned to 4-week training sessions of either aquatic therapy(n=19) or land-based aerobic exercise(n=18). Isometric strength was measured using an isokinetic dynamometer...
March 12, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29521212/linking-antimicrobial-potential-of-natural-products-derived-from-aquatic-organisms-and-microbes-involved-in-alzheimer-s-disease-a-review
#6
Dejan Stojkovic, Marina Kostic, Marija Smiljkovic, Milena Aleksic, Perica Vasiljevic, Milos Nikolic, Marina Sokovic
The following review is oriented towards microbes linked to Alzheimer's disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp...
March 8, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29511502/anti-diabetic-effects-of-sargassum-oligocystum-on-streptozotocin-induced-diabetic-rat
#7
Samad Akbarzadeh, Hossein Gholampour, Parviz Farzadinia, Adel Daneshi, Bahman Ramavandi, Ali Moazzeni, Mojtaba Keshavarz, Afshar Bargahi
Objectives: Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic source, along with the variety of health and therapeutic benefits. In the present research, with respect to the traditional and ethnic uses of Sargassum oligocystum algae for healing of some diseases which have similar metabolic mechanism to the diabetes, its anti-diabetic effects in animal model was proposed...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29510254/the-functionality-of-prebiotics-as-immunostimulant-evidences-from-trials-on-terrestrial-and-aquatic-animals
#8
REVIEW
Asad Nawaz, Allah Bakhsh Javaid, Sana Irshad, Seyed Hossein Hoseinifar, Hanguo Xiong
The gut immune system is, the main option for maintaining host's health, affected by numerous factors comprising dietary constituents and commensal bacteria. These dietary components that affect the intestinal immunity and considered as an alternative of antibiotics are called immunosaccharides. Fructooligosaccharide (FOS), Galactooligosaccharide (GOS), inulin, dietary carbohydrates, and xylooligosaccharide (XOS) are among the most studied prebiotics in human as well as in aquaculture. Although prebiotics and probiotics have revealed potential as treatment for numerous illnesses in both human and fish, a comprehensive understanding of the molecular mechanism behind direct and indirect effect on the intestinal immune response will help more and perhaps extra effective therapy intended for ailments...
March 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29495270/bacteriophage-interactions-with-marine-pathogenic-vibrios-implications-for-phage-therapy
#9
REVIEW
Panos G Kalatzis, Daniel Castillo, Pantelis Katharios, Mathias Middelboe
A global distribution in marine, brackish, and freshwater ecosystems, in combination with high abundances and biomass, make vibrios key players in aquatic environments, as well as important pathogens for humans and marine animals. Incidents of Vibrio -associated diseases (vibriosis) in marine aquaculture are being increasingly reported on a global scale, due to the fast growth of the industry over the past few decades years. The administration of antibiotics has been the most commonly applied therapy used to control vibriosis outbreaks, giving rise to concerns about development and spreading of antibiotic-resistant bacteria in the environment...
February 24, 2018: Antibiotics
https://www.readbyqxmd.com/read/29468553/crispr-cas9-mediated-knockout-of-rb1-in-xenopus-tropicalis
#10
Thomas Naert, Kris Vleminckx
At this time, no molecular targeted therapies exist for treatment of retinoblastoma. This can be, in part, attributed to the lack of animal models that allow for both rapid identification of novel therapeutic targets and hypothesis driven drug testing. Within this scope, we have recently reported the first genuine genetic nonmammalian retinoblastoma cancer model within the aquatic model organism Xenopus tropicalis (Naert et al., Sci Rep 6: 35263, 2016). Here we describe the methods to generate rb1 mosaic mutant Xenopus tropicalis by employing the CRISPR/Cas9 technology...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29458923/a-bicentric-controlled-study-on-the-effects-of-aquatic-ai-chi-in-parkinson-disease
#11
Sagrario Pérez-de la Cruz
OBJECTIVES: Various exercise strategies have been suggested to address movement deficits in order to improve motor function and quality of life for individuals in the early or moderate stages of Parkinson disease. The purpose is to evaluate the effects of an aquatic Ai Chi intervention on balance, gait speed and quality of life of patients. DESIGN AND INTERVENTION: Twenty-nine people with Parkinson disease participated in this pilot study. People were randomized into (1) aquatic Ai Chi program (experimental group) and (2) a dry land conventional Western physical therapy intervention (control group)...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29407696/trace-analysis-of-61-natural-and-synthetic-progestins-in-river-water-and-sewage-effluents-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#12
Xiaoyan Shen, Hong Chang, Dezhi Sun, Linxia Wang, Fengchang Wu
A broad number of natural and synthetic progestins are widely used in human and veterinary therapies. Although progestins exhibit adverse effects in aquatic organisms, information about environmental occurrence and fate have been limited to several compounds, hampering the accuracy of risk assessments of the compounds. In this study, a selective and sensitive analytical method was established to simultaneously determine 19 natural and 42 synthetic progestins in environmental waters, and the synthetic progestins included 19-nortestosterone, 17α-hydroxyprogesterone and progesterone derivatives...
February 1, 2018: Water Research
https://www.readbyqxmd.com/read/29394027/coordination-complexes-of-titanium-iv-for-anticancer-therapy
#13
Edit Y Tshuva, Maya Miller
Titanium(IV) coordination complexes represent attractive alternatives to platinumbased anticancer drugs. The advantage of the titanium metal lies in its low toxicity, and the hydrolysis of titanium(IV) coordination complexes in biological water-based environment to the safe and inert titanium dioxide is an enormous benefit. On the other hand, the rapid hydrolysis of titanium(IV) complexes in biological environment and their rich aquatic chemistry hampered the exploration and the development of effective compounds...
February 5, 2018: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/29322273/the-emerging-influenza-virus-threat-status-and-new-prospects-for-its-therapy-and-control
#14
REVIEW
Binod Kumar, Kumari Asha, Madhu Khanna, Larance Ronsard, Clement Adebajo Meseko, Melvin Sanicas
Influenza A viruses (IAVs) are zoonotic pathogens that cause yearly outbreaks with high rates of morbidity and fatality. The virus continuously acquires point mutations while circulating in several hosts, ranging from aquatic birds to mammals, including humans. The wide range of hosts provides influenza A viruses greater chances of genetic re-assortment, leading to the emergence of zoonotic strains and occasional pandemics that have a severe impact on human life. Four major influenza pandemics have been reported to date, and health authorities worldwide have shown tremendous progress in efforts to control epidemics and pandemics...
April 2018: Archives of Virology
https://www.readbyqxmd.com/read/29313176/effectiveness-of-a-multisystem-aquatic-therapy-for-children-with-autism-spectrum-disorders
#15
Giovanni Caputo, Giovanni Ippolito, Marina Mazzotta, Luigi Sentenza, Mara Rosaria Muzio, Sara Salzano, Massimiliano Conson
Aquatic therapy improves motor skills of persons with Autism Spectrum Disorders (ASD), but its usefulness for treating functional difficulties needs to be verified yet. We tested effectiveness of a multisystem aquatic therapy on behavioural, emotional, social and swimming skills of children with ASD. Multisystem aquatic therapy was divided in three phases (emotional adaptation, swimming adaptation and social integration) implemented in a 10-months-programme. At post-treatment, the aquatic therapy group showed significant improvements relative to controls on functional adaptation (Vineland Adaptive Behavior Scales), emotional response, adaptation to change and on activity level (Childhood Autism Rating Scale)...
January 8, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29283402/real-time-monitoring-and-analysis-of-zebrafish-electrocardiogram-with-anomaly-detection
#16
Michael Lenning, Joseph Fortunato, Tai Le, Isaac Clark, Ang Sherpa, Soyeon Yi, Peter Hofsteen, Geethapriya Thamilarasu, Jingchun Yang, Xiaolei Xu, Huy-Dung Han, Tzung K Hsiai, Hung Cao
Heart disease is the leading cause of mortality in the U.S. with approximately 610,000 people dying every year. Effective therapies for many cardiac diseases are lacking, largely due to an incomplete understanding of their genetic basis and underlying molecular mechanisms. Zebrafish ( Danio rerio ) are an excellent model system for studying heart disease as they enable a forward genetic approach to tackle this unmet medical need. In recent years, our team has been employing electrocardiogram (ECG) as an efficient tool to study the zebrafish heart along with conventional approaches, such as immunohistochemistry, DNA and protein analyses...
December 28, 2017: Sensors
https://www.readbyqxmd.com/read/29172739/effect-of-aquatic-exercise-on-mental-health-functional-autonomy-and-oxidative-dysfunction-in-hypertensive-adults
#17
Luciano Acordi Da Silva, Lorhan Menguer, Janaina Motta, Beatriz Dieke, Sindianra Mariano, Gladson Tasca, Rubya Pereira Zacaron, Paulo Cesar Lock Silveira, Pinho Ricardo Aurino
The aquatic exercise is an effective non-pharmacological therapy for prevention and control of hypertension. The objective of the present study was to investigate the effect of aquatic exercise on mental health, functional autonomy, and oxidative dysfunction in hypertensive adults. Methodologically 29 adults (mean age 53 ± 7.5 years) were included in the study, and were randomly grouped as hypertensive (n = 16) and non-hypertensive (n = 13). Both groups underwent low-intensity aquatic exercise program for 12 weeks...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29132820/optimization-and-application-of-fabric-phase-sorptive-extraction-coupled-to-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-the-determination-of-cytostatic-drug-residues-in-environmental-waters
#18
Sergio Santana-Viera, Rayco Guedes-Alonso, Zoraida Sosa-Ferrera, José Juan Santana-Rodríguez, Abuzar Kabir, Kenneth G Furton
Every year, hundreds of tons of organic pollutants reach the environment through effluents released from wastewater treatment plants worldwide, and many of these compounds have harmful effects on the aquatic ecosystem. A new class of emerging pollutants of high concern is cytostatic drugs, which are designed to treat different types of cancers by attacking cells. Environmental concentrations of cytostatic drugs are known to be in the range of ngL-1 , and for this reason, it is imperative to develop analytical methods of extraction and preconcentration to allow for subsequent instrumental analysis of these drugs...
December 22, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29109372/marine-algae-as-source-of-novel-antileishmanial-drugs-a-review
#19
REVIEW
Lauve Rachel Tchokouaha Yamthe, Regina Appiah-Opong, Patrick Valere Tsouh Fokou, Nole Tsabang, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko, Michael David Wilson
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials, pentamidine, paromomycin, liposomal amphotericin B, and miltefosine. However, their low efficacy, long-course treatment regimen, high toxicity, adverse side effects, induction of parasite resistance and high cost require the need for better drugs given that antileishmanial vaccines may not be available in the near future...
October 29, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29096309/evaluation-of-acute-and-chronic-ecotoxicity-of-cyclophosphamide-ifosfamide-their-metabolites-transformation-products-and-uv-treated-samples
#20
Chiara Russo, Margherita Lavorgna, Marjeta Česen, Tina Kosjek, Ester Heath, Marina Isidori
Cyclophosphamide (CP) and Ifosfamide (IF) are two nitrogen mustard drugs widely prescribed in cancer therapy. They are continuously released via excreta into hospital and urban wastewaters reaching wastewater treatment plants. Although CP and IF, their metabolites and transformation products (TPs) residues have been found in the aquatic environment from few ng L-1 to tens of μg L-1 , their environmental toxic effects are still not well known. The present study aimed to investigate the acute and chronic ecotoxicity of CP and IF and their commercially available human metabolites/TPs, i...
February 2018: Environmental Pollution
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