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Lipid Recommendations

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https://www.readbyqxmd.com/read/28215454/sperm-quality-and-oxidative-status-as-affected-by-homogenization-of-liquid-stored-boar-semen-diluted-in-short-and-long-term-extenders
#1
Mariana B Menegat, Ana Paula G Mellagi, Rafael C Bortolin, Tila A Menezes, Amanda R Vargas, Mari Lourdes Bernardi, Ivo Wentz, Daniel P Gelain, José Cláudio F Moreira, Fernando P Bortolozzo
Homogenization of diluted boar semen during storage has for a long time been regarded as beneficial. Recent studies indicated an adverse effect of homogenization on sperm quality for yet unknown reasons. This study aimed to verify the effect of homogenization on sperm parameters and to elucidate the impact of oxidative stress. Twenty-one normospermic ejaculates (21 boars) were diluted with Androstar(®) Plus (AND) and Beltsville Thawing Solution (BTS). Semen doses were submitted to no-homogenization (NoHom) or twice-a-day manual homogenization (2xHom) during storage at 17°C for 168h...
February 12, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28213597/retrospective-examination-of-lipid-lowering-treatment-patterns-in-a-real-world-high-risk-cohort-in-the-uk-in-2014-comparison-with-the-national-institute-for-health-and-care-excellence-nice-2014-lipid-modification-guidelines
#2
Dylan L Steen, Irfan Khan, David Ansell, Robert J Sanchez, Kausik K Ray
BACKGROUND: In 2014, guidelines from the National Institute for Health and Care Excellence (NICE) provided updated recommendations on lipid-modifying therapy (LMT). We assessed clinical practice contemporaneous to release of these guidelines in a UK general practice setting for secondary and high-risk primary-prevention populations, and extrapolated the findings to UK nation level. METHODS: Patients from The Health Improvement Network database with the following criteria were included: lipid profile in 2014 (index date); ≥20 years of age; ≥2 years representation in database prior to index; ≥1 statin indication either for atherosclerotic cardiovascular disease (ASCVD) or the non-ASCVD conditions high-risk diabetes mellitus and/or chronic kidney disease...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28210016/oxidative-stress-marker-and-pregnancy-induced-hypertension
#3
Dragica Draganovic, Nenad Lucic, Dragica Jojic
BACKGROUND: Pregnancy induced hypertension (PIH) is a state of extremely increased oxidative stress. Hence, research and test of role and significance of oxidative stress in hypertensive disturbance in pregnancy is very important. AIM: Aims of this research were to determine a level of thiobarbituric acid reactive substance (TBARS) as oxidative stress marker in blood of pregnant woman with pregnancy induced hypertension and to analyze correlation of TBARS values with blood pressure values in pregnancy induced hypertensive pregnant women...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209375/suboptimal-achievement-of-low-density-lipoprotein-cholesterol-targets-in-french-patients-with-coronary-heart-disease-contemporary-data-from-the-dysis-ii-acs-chd-study
#4
Jean Ferrières, Maja Velkovski Rouyer, Dominik Lautsch, Veronica Ashton, Baishali M Ambegaonkar, Philippe Brudi, Anselm K Gitt
BACKGROUND: European guidelines recommend a low-density lipoprotein cholesterol (LDL-C) target of<1.8mmol/L (70mg/dL), and/or a≥50% reduction when the target level cannot be reached, for patients at very high cardiovascular risk, and high-potency lipid-lowering therapy (LLT) in patients with an acute coronary syndrome (ACS). AIM: To document the prevalence of lipid abnormalities and the achievement of lipid targets among patients surviving an ACS and in patients with stable coronary heart disease (CHD), using data from the DYSIS II study...
February 13, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28209292/cholesterol-screening-and-treatment-practices-and-preferences-a-survey-of-united-states-pediatricians
#5
Sarah D de Ferranti, Angie Mae Rodday, Susan K Parsons, William L Cull, Karen G O'Connor, Stephen R Daniels, Laurel K Leslie
OBJECTIVES: To determine pediatricians' practices, attitudes, and barriers regarding screening for and treatment of pediatric dyslipidemias in 9- to 11-year-olds and 17- to 21-year-olds. STUDY DESIGN: American Academy of Pediatrics (AAP) 2013-2014 Periodic Survey of a national, randomly selected sample of 1627 practicing AAP physicians. Pediatricians' responses were described and modeled. RESULTS: Of 614 (38%) respondents who met eligibility criteria, less than half (46%) were moderately/very knowledgeable about the 2008 AAP cholesterol statement; fewer were well-informed about 2011 National Heart, Lung, and Blood Institute Guidelines or 2007 US Preventive Service Task Force review (both 26%)...
February 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28207495/lipids-and-lipid-changes-with-synthetic-and-biologic-disease-modifying-antirheumatic-drug-therapy-in-rheumatoid-arthritis-implications-for-cardiovascular-risk
#6
Elena Myasoedova
PURPOSE OF REVIEW: To highlight recently published studies addressing lipid changes with disease-modifying antirheumatic drug use and outline implications on cardiovascular outcomes in rheumatoid arthritis (RA). RECENT FINDINGS: Growing evidence suggests lower lipid levels are present in patients with active RA vs. general population, and significant modifications of lipid profile with inflammation suppression. Increase in lipid levels in patients with RA on synthetic and biological disease-modifying antirheumatic drugs may be accompanied by antiatherogenic changes in lipid composition and function...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28198920/exogenous-enzyme-complex-prevents-intestinal-soybean-meal-induced-enteritis-in-mugil-liza-valenciennes-1836-juvenile
#7
Leonardo R V Ramos, Virgínia F Pedrosa, Agnes Mori, Carlos F F DE Andrade, Luis A Romano, Paulo C Abreu, Marcelo B Tesser
Four soybean meal-based diets containing increasing levels of an enzyme complex (E50, E100, E150 and E200 at 50, 100, 150 and 200 g ton-1, respectively) and one soybean meal-based diet without the enzyme complex (E0) were fed in triplicate to M. liza juveniles in a semi-static flow system with 20 fish per tank for 75 days. There were no differences between the treatments for animal performance parameters, but fish fed the enzyme complex treatment exhibited significantly (P<0.05) higher values of calcium bone retention compared with control fish...
February 9, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28197293/the-prevalence-of-metabolic-syndrome-in-coronary-artery-disease-patients
#8
Farzaneh Montazerifar, Ahmad Bolouri, Milad Mahmoudi Mozaffar, Mansour Karajibani
BACKGROUND: Metabolic syndrome (MetS) is a worldwide health problem, which is growing in Iranian adults. MetS is associated with risk of type 2 diabetes and coronary artery disease (CAD). In this study, we aimed to investigate the prevalence of MetS and its individual components in CAD patients. METHODS: This cross-sectional study was performed on 200 CAD patients who had undergone elective coronary angiography at the cardiology department. Anthropometric indices including waist circumference (WC) and body mass index were measured...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28193107/annals-express-evaluation-of-commonly-used-tear-sampling-methods-and-their-relevance-in-subsequent-biochemical-analysis
#9
Aniko Rentka, Krisztina Koroskenyi, Jolan Harsfalvi, Zoltan Szekanecz, Gabriella Szucs, Peter Szodoray, Adam Kemeny-Beke
The human precorneal tear film (PCTF) is a special body fluid, since it is a complex mixture of proteins, lipids small bioactive molecules and their concentrations and relative distribution represent not only the metabolic state of the ocular surface but also the systemic and local homeostasis of the outer eye and the human body. This suggests that biochemical analysis of the PCTF composition may provide a non-invasive tool for diagnosis and monitoring of disease progression or treatment efficacy in human medicine...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28193003/on-mass-ambiguities-in-high-resolution-shotgun-lipidomics
#10
Chris Bielow, Guido Mastrobuoni, Marica Orioli, Stefan Kempa
Mass-spectrometry-based lipidomics aims to identify as many lipid species as possible from complex biological samples. Due to the large combinatorial search space, unambiguous identification of lipid species is far from trivial. Mass ambiguities are common in direct-injection shotgun experiments, where an orthogonal separation (e.g., liquid chromatography) is missing. Using the rich information within available lipid databases, we generated a comprehensive rule set describing mass ambiguities, while taking into consideration the resolving power (and its decay) of different mass analyzers...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28187724/case-management-of-patients-with-type-2-diabetes-mellitus-a-cross-sectional-survey-in-chongqing-china
#11
Miao He, Jiaqi Gao, Weiwei Liu, Xiaojun Tang, Shenglan Tang, Qian Long
BACKGROUND: Type 2 diabetes mellitus has been identified as one of the priority diseases and included in the essential public health service package in China. This study investigated the frequency of follow-up visits and contents of care for case management of patients with Type 2 diabetes in Chongqing located in the western China, in terms of the regional practice guideline; and analyzed factors associated with the use of care. METHODS: A cross-sectional survey was conducted with patients diagnosed with Type 2 diabetes in two areas in Chongqing...
February 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28185213/hyperlipoproteinaemia-a-apheresis-and-emerging-therapies
#12
Anja Vogt
A high level of lipoprotein(a) (Lp(a)) is recognized as an independent and additional cardiovascular risk factor contributing to the risk of early onset and progressive course of cardiovascular disease (CVD). All lipid lowering medications in use mainly lower low density lipoprotein-cholesterol (LDL-c) with no or limited effect on levels of Lp(a). Niacin, the only component lowering Lp(a), is firstly often poorly tolerated and secondly not available anymore in many countries. A level of <50 mg/dl was recommended recently as the cut off level for clinical use and decision making...
February 9, 2017: Clinical Research in Cardiology Supplements
https://www.readbyqxmd.com/read/28185186/eicosacell-an-imaging-based-assay-to-identify-spatiotemporal-eicosanoid-synthesis
#13
Christianne Bandeira-Melo, Ligia Almeida Paiva, Natália R T Amorim, Peter F Weller, Patricia T Bozza
Eicosanoids are bioactive lipids derived from enzymatic metabolism of arachidonic acid via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. These lipids are newly formed and nonstorable molecules that have important roles in physiological and pathological processes. The particular interest to determine intracellular compartmentalization of eicosanoid-synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and in delineating functional intracellular and extracellular actions of eicosanoids...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28181835/irinotecan-encapsulated-double-reverse-thermosensitive-nanocarrier-system-for-rectal-administration
#14
Fakhar Ud Din, Ju Yeon Choi, Dong Wuk Kim, Omer Mustapha, Dong Shik Kim, Raj Kumar Thapa, Sae Kwang Ku, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) for rectal administration was developed as an alternative. The DRTN was fabricated by dispersing the thermosensitive irinotecan-encapsulated solid lipid nanoparticles (SLN) in the thermosensitive poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its rectal administration to rats and tumor-bearing mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181057/lipoprotein-a-in-nephrological-patients
#15
Bernd Hohenstein
In contrast to existing EAS/ESC guidelines on the management of lipid disorders, current recommendations from nephrological societies are very conservative and restrictive with respect to any escalation of lipid lowering/statin therapy. Furthermore, lipoprotein(a) (Lp(a)) - an established cardiovascular risk factor - has not even been mentioned. While a number of retrospective and prospective studies suggested that Lp(a) has relevant predictive value and might have - at least in stage-3 chronic kidney disease (CKD) - the same negative effects if draged along in non-CKD patients, there is no guidance on diagnostic or therapeutic procedures...
February 8, 2017: Clinical Research in Cardiology Supplements
https://www.readbyqxmd.com/read/28177375/production-composition-fatty-acid-profile-and-sensory-analysis-of-goat-milk-in-goats-fed-buriti-oil
#16
J S Morais, L R Bezerra, A M A Silva, M J Araújo, R L Oliveira, R L Edvan, J N C Torreão, D P D Lanna
This study evaluated the effects of replacing ground corn with buriti oil ( L.) on feed intake and digestibility and on the production, composition, fatty acid profile and sensory characteristics of goat milk. A double Latin square (4 × 4) was used; eight goats were distributed in a completely randomized design. The square comprised four periods and four buriti oil concentration (0.00; 1.50; 3.00 and 4.50% of total DM) replacing corn. Intakes of DM, CP, NDF, ADF, non-fibrous carboydrates (NFC) and TDN were not affected by the replacement of corn with oil in the diet...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28174695/the-effect-of-oral-vaccination-with-mycobacterium-bovis-bcg-on-the-development-of-tuberculosis-in-captive-european-badgers-meles-meles
#17
Mark A Chambers, Frank Aldwell, Gareth A Williams, Si Palmer, Sonya Gowtage, Roland Ashford, Deanna J Dalley, Dipesh Davé, Ute Weyer, Francisco J Salguero, Alejandro Nunez, Allan K Nadian, Timothy Crawshaw, Leigh A L Corner, Sandrine Lesellier
The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for a proportion of the tuberculosis (TB) cases seen in cattle in the United Kingdom and Republic of Ireland. An injectable preparation of the bacillus Calmette-Guérin (BCG) vaccine is licensed for use in badgers in the UK and its use forms part of the bovine TB eradication plans of England and Wales. However, there are practical limitations to the widespread application of an injectable vaccine for badgers and a research priority is the development of an oral vaccine deliverable to badgers in bait...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28173956/-spanish-adaptation-of-the-2016-european-guidelines-on-cardiovascular-disease-prevention-in-clinical-practice
#18
M Á Royo-Bordonada, P Armario, J M Lobos Bejarano, J Pedro-Botet, F Villar Alvarez, R Elosua, C Brotons Cuixart, O Cortés, B Serrano, M Cammafort Babkowski, A Gil Núñez, A Pérez, A Maiques, A de Santiago Nocito, A Castro, E Alegría, C Baeza, M Herranz, S Sans, P Campos
The VI European Guidelines for Cardiovascular Prevention recommend combining population and high-risk strategies with lifestyle changes as a cornerstone of prevention, and propose the SCORE function to quantify cardiovascular risk. The guidelines highlight disease specific interventions, and conditions as women, young people and ethnic minorities. Screening for subclinical atherosclerosis with noninvasive imaging techniques is not recommended. The guidelines distinguish four risk levels (very high, high, moderate and low) with therapeutic objectives for lipid control according to risk...
February 4, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28156151/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-atherosclerosis
#19
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Each Recommendation is based on a diligent review of the clinical evidence with transparent incorporation of subjective factors. RESULTS: The Executive Summary of this document contains 87 Recommendations of which 45 are Grade A (51...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28150104/assessment-of-six-cardiovascular-risk-calculators-in-mexican-mestizo-patients-with-rheumatoid-arthritis-according-to-the-eular-2015-2016-recommendations-for-cardiovascular-risk-management
#20
Dionicio A Galarza-Delgado, Jose R Azpiri-Lopez, Iris J Colunga-Pedraza, Jesus A Cardenas-de la Garza, Raymundo Vera-Pineda, Griselda Serna-Peña, Rosa I Arvizu-Rivera, Adrian Martinez-Moreno, Martin Wah-Suarez, Mario A Garza Elizondo
Variability of the 10-year cardiovascular (CV) risk predicted by the Framingham Risk Score (FRS) using lipids, FRS using body mass index (BMI), Reynolds Risk Score (RRS), QRISK2, Extended Risk Score-Rheumatoid Arthritis (ERS-RA), and algorithm developed by the American College of Cardiology and the American Heart Association in 2013 (ACC/AHA 2013) according to the European League Against Rheumatism (EULAR) 2015/2016 update of its evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis (RA) has not been evaluated in Mexican mestizo patients...
February 1, 2017: Clinical Rheumatology
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