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Mechanical Valve

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https://www.readbyqxmd.com/read/29150326/concomitant-mitral-valve-procedures-in-patients-undergoing-implantation-of-continuous-flow-left-ventricular-assist-devices-an-intermacs-database-analysis
#1
Jason O Robertson, David C Naftel, Susan L Myers, Ryan J Tedford, Susan M Joseph, James K Kirklin, Scott C Silvestry
BACKGROUND: Management of existing mitral valve (MV) disease in patients undergoing left ventricular assist device (LVAD) implantation remains controversial. METHODS: Among continuous-flow LVAD patients with moderate to severe mitral regurgitation entered into the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database between April 2008 and March 2014 (n = 4,930), outcomes were compared between patients who underwent MV repair (MVr, n = 252), MV replacement (MVR, n = 11) and no MV procedure (no MVP, n = 4,667)...
October 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29148548/acrylate-based-materials-for-heart-valve-scaffold-engineering
#2
Rosaria Santoro, Seshasailam Venkateswaran, Francesco Amadeo, Rong Zhang, Maura Brioschi, Anthony Callanan, Marco Agrifoglio, Cristina Banfi, Mark Bradley, Maurizio Pesce
Calcific aortic valve disease (CAVD) is the most frequent cardiac valve pathology. Its standard treatment consists of surgical replacement either with mechanical (metal made) or biological (animal tissue made) valve prostheses, both of which have glaring deficiencies. In the search for novel materials to manufacture artificial valve tissue, we have conducted a high-throughput screening with subsequent up-scaling to identify non-degradable polymer substrates that promote valve interstitial cells (VICs) adherence/growth and, at the same time, prevent their evolution toward a pro-calcific phenotype...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147966/polyamine-concentration-is-increased-in-thoracic-ascending-aorta-of-patients-with-bicuspid-aortic-valve
#3
Amalia Forte, Mario Grossi, Ciro Bancone, Marilena Cipollaro, Marisa De Feo, Per Hellstrand, Lo Persson, Bengt-Olof Nilsson, Alessandro Della Corte
Polyamines are cationic molecules synthesized via a highly regulated pathway, obtained from the diet or produced by the gut microbiota. They are involved in general molecular and cellular phenomena that play a role also in vascular disease. Bicuspid aortic valve (BAV) is a congenital malformation associated to a greater risk of thoracic ascending aorta (TAA) aneurysm, whose pathogenesis is not yet well understood. We focused on differential analysis of key members of polyamine pathway and on polyamine concentration in non-dilated TAA samples from patients with either stenotic tricuspid aortic valve (TAV) or BAV (diameter ≤ 45 mm), vs...
November 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29146626/clinical-outcomes-in-1731-patients-undergoing-mitral-valve-surgery-for-rheumatic-valve-disease
#4
Wan Kee Kim, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
OBJECTIVE: Unlike degenerative mitral valve (MV) disease, the advantages of valve repair procedure over replacement have been debated in rheumatic MV disease. This study aims to evaluate the impact of procedural types on long-term outcomes through analyses on a large data set from an endemic area of rheumatic disease. METHODS: We evaluated 1731 consecutive patients (52.3±12.5 years; 1190 women) undergoing MV surgery for rheumatic MV disease between 1997 and 2015...
November 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29146485/in-frame-variants-in-flna-proximal-rod-1-domain-associate-with-a-predominant-cardiac-valvular-phenotype
#5
Luis Fernández, Jair Tenorio, Coral Polo-Vaquero, Elena Vallespín, María Palomares-Bralo, Sixto García-Miñaúr, Fernando Santos-Simarro, Pedro Arias, Hernán Carnicer, Silvina Giannivelli, Juan Medina, Rosa Pérez-Piaya, Jorge Solís, Mónica Rodríguez, Alexandra Villagrá, Laura Rodríguez, Julián Nevado, Víctor Martínez-Glez, Karen E Heath, Pablo Lapunzina
INTRODUCTION AND OBJECTIVES: X-linked cardiac valvular dysplasia is a rare form of male-specific congenital heart defect mainly characterized by myxomatous degeneration of the atrioventricular valves with variable hemodynamic consequences. It is caused by genetic defects in FLNA-encoded filamin A, a widely expressed actin-binding protein that regulates cytoskeleton organization. Filamin A loss of function has also been associated with often concurring neurologic and connective tissue manifestations, with mutations in the first half of the Rod 1 domain apparently expressing the full cardiac phenotype...
November 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29142324/an-algorithm-for-the-beat-to-beat-assessment-of-cardiac-mechanics-during-sleep-on-earth-and-in-microgravity-from-the-seismocardiogram
#6
Marco Di Rienzo, Emanuele Vaini, Prospero Lombardi
Seismocardiogram, SCG, is the measure of precordial vibrations produced by the beating heart, from which cardiac mechanics may be explored on a beat-to-beat basis. We recently collected a large amount of SCG data (>69 recording hours) from an astronaut to investigate cardiac mechanics during sleep aboard the International Space Station and on Earth. SCG sleep recordings are characterized by a prolonged duration and wide heart rate swings, thus a specific algorithm was developed for their analysis. In this article we describe the new algorithm and its performance...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136138/calcific-aortic-valve-stenosis-hard-disease-in-the-heart-a-biomolecular-approach-towards-diagnosis-and-treatment
#7
Frederique E C M Peeters, Steven J R Meex, Marc R Dweck, Elena Aikawa, Harry J G M Crijns, Leon J Schurgers, Bas L J H Kietselaer
Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become an increasing economic and health burden. Once present, it inevitably progresses and has a poor prognosis in symptomatic patients. No medical therapies are proven to be effective in holding or reducing disease progression. Therefore, aortic valve replacement remains the only available treatment option. Improved knowledge of the mechanisms underlying disease progression has provided us with insights that CAVS is not a passive disease...
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136118/ventricular-arterial-and-aortic-mechanical-valve-dehiscence-evaluated-by-advanced-post-processing-techniques-in-multislice-computed-tomography
#8
Paulo Ernando Ferraz Cavalcanti, Michel Pompeu Barros de Oliveira Sá, Ricardo Felipe de Albuquerque Lins, Alexandre Motta de Menezes
No abstract text is available yet for this article.
November 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29135480/mechanical-surface-area-of-prosthetic-heart-valve-adverse-clinical-impact-of-large-mechanical-valve-in-mitral-position
#9
Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Jae-Hun Kim, Sung Mok Kim, Pyo Won Park
Although thromboembolic accidents are serious adverse events associated with mechanical mitral valves, there have been no studies on the clinical impact of the large mechanical surface areas (MSAs) of mechanical mitral prostheses. Between 1995 and 2010, 488 consecutive adult patients underwent isolated mechanical mitral valve replacement. We measured the MSA via three-dimensional computed tomography for each prosthesis. Mean patient age was 50.6 ± 11.1 years. The mean body surface area (BSA) and MSA index (MSAI, MSA/BSA) were 1...
November 8, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29134537/current-status-of-cardiovascular-surgery-in-japan-2013-and-2014-a-report-based-on-the-japan-cardiovascular-surgery-database-4-valvular-heart-surgery
#10
Kiyoharu Nakano, Norimichi Hirahara, Noboru Motomura, Hiroaki Miyata, Shinichi Takamoto
Data from the Japan cardiovascular surgery database from 2013 to 2014 were analyzed to demonstrate the mortality rate and choice of surgical procedures, especially concerning the selection of valve prosthesis for each valve position and patient age group, and the effects of preoperative complications on mortality and prosthetic valve selection. The proportion of each surgical procedure was compared for each patient age in the aortic, mitral, and tricuspid positions. The proportion of mechanical valve prostheses was 23...
November 13, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29134471/the-impact-of-heat-treatment-on-porcine-heart-valve-leaflets
#11
R Glenn Hepfer, Peng Chen, Kelvin G M Brockbank, Alyce L Jones, Amanda K Burnette, Zhen Chen, Elizabeth D Greene, Lia H Campbell, Hai Yao
The purpose of this study was to determine the impact of elevated temperature exposure in tissue banking on soft tissues. A secondary objective was to determine the relative ability of various assays to detect changes in soft tissues due to temperature deviations. Porcine pulmonary heart valve leaflets exposed to 37 °C were compared with those incubated at 52 and 67 °C for 10, 30 and 100 min. The analytical methods consisted of (1) viability assessment using the resazurin assay, (2) collagen content using the Sircol assay, and (3) permeability assessment using an electrical conductivity assay...
November 13, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29129374/the-jarvik-2000-left-ventricular-assist-device-as-a-bridge-to-transplantation-japanese-registry-for-mechanically-assisted-circulatory-support
#12
Hiroki Kohno, Goro Matsumiya, Yoshiki Sawa, Minoru Ono, Yoshikatsu Saiki, Akira Shiose, Kenji Yamazaki, Yoshiro Matsui, Hiroshi Niinami, Hikaru Matsuda, Soichiro Kitamura, Takeshi Nakatani, Shunei Kyo
BACKGROUND: The Jarvik 2000 ventricular assist device features a miniaturized intraventricular pump and an intermittent low-speed function that facilitates aortic valve opening. Despite its long history, little is known about the Jarvik device with regard to post-implantation outcomes. METHODS: Prospectively collected data from 13 participating hospitals were extracted from the Japanese Registry for Mechanically Assisted Circulatory Support database to analyze mortality, morbidity and de-novo aortic regurgitation...
October 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29129075/strontium-oxide-tunnel-barriers-for-high-quality-spin-transport-and-large-spin-accumulation-in-graphene
#13
Simranjeet Singh, Jyoti Katoch, Tiancong Zhu, Ryan J Wu, Adam S Ahmed, Walid Amamou, Dongying Wang, K Andre Mkhoyan, Roland K Kawakami
The quality of the tunnel barrier at the ferromagnet/graphene interface plays a pivotal role in graphene spin valves by circumventing the impedance mismatch problem, decreasing interfacial spin dephasing mechanisms and decreasing spin absorption back into the ferromagnet. It is thus crucial to integrate superior tunnel barriers to enhance spin transport and spin accumulation in graphene. Here, we employ a novel tunnel barrier, strontium oxide (SrO), onto graphene to realize high quality spin transport as evidenced by room-temperature spin relaxation times exceeding a nanosecond in graphene on silicon dioxide substrates...
November 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/29128571/exercise-testing-in-mitral-regurgitation
#14
REVIEW
Raluca Dulgheru, Stella Marchetta, Tadafumi Sugimoto, Yun Yun Go, Alexandra Girbea, Oury Cécile, Patrizio Lancellotti
Mitral regurgitation (MR) is the second most common valvular heart disease referred for corrective surgery. Diagnostic and management dilemmas are not uncommon when dealing with MR patients. Exercise testing plays an important role in sorting out some of these clinical challenges. In primary asymptomatic MR, exercise testing allows symptom assessment, confident link of symptoms to valve disease severity, safe deferral of surgery for the next 1-year in patients with preserved exercise capacity, insights into the mechanism of exercise-induced dyspnea and helps in individual risk stratification...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29127746/-surgical-treatment-of-aortic-root-aneurysm-comparison-of-bentall-procedure-and-david-reimplantation-of-aortic-valve
#15
Jiří Ničovský, Jiří Ondrášek, Jan Černý, Daniela Žáková, Petr Němec
INTRODUCTION: The aortic root aneurysm is associated with a more frequent occurrence of aortic dissection and development of aortic regurgitation. The aim of this study was to compare outcomes of composite graft replacement and valve sparing root replacement in treating aortic root aneurysms. METHODS: From January 2006 to December 2015 a total of 137 patients (mean age 46.3 ± 14.5, range 16-65) underwent elective surgery for aortic root aneurysm without valvular structural defects...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29125921/management-of-anticoagulation-in-patients-with-prostate-cancer-receiving-enzalutamide
#16
Joseph J Shatzel, Molly M Daughety, Sven R Olson, Tomasz M Beer, Thomas G DeLoughery
Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic, castration-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse effect profile. Metastatic prostate cancer is a disease of older men, a population with an increased incidence of medical comorbidities warranting anticoagulation. Prostate cancer itself, along with some of its therapies, is also prothrombotic...
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29123847/unilateral-cardiogenic-pulmonary-edema-associated-with-acute-mitral-regurgitation
#17
Masahiro Kashiura, Kazuya Tateishi, Taro Yokoyama, Mioko Jujo, Takahiro Tanabe, Kazuhiro Sugiyama, Akiko Akashi, Yuichi Hamabe
Case: Two cases of cardiogenic unilateral pulmonary edema are reported. Both patients presented to the emergency department with dyspnea, and chest radiography revealed unilateral infiltration, which mimics pulmonary disease. However, the patients were diagnosed with cardiogenic pulmonary edema, because echocardiography showed severe mitral regurgitation with an eccentric jet. Outcome: The patients underwent mitral valve replacement and were discharged without complications...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122631/mitral-valve-prolapse-multimodality-imaging-and-genetic-insights
#18
REVIEW
Purvi Parwani, Jean-Francois Avierinos, Robert A Levine, Francesca Nesta Delling
Mitral valve prolapse (MVP) is a common heritable valvulopathy affecting approximately 2.4% of the population. It is the most important cause of primary mitral regurgitation (MR) requiring surgery. MVP is characterized by fibromyxomatous changes and displacement of one or both mitral leaflets into the left atrium. Echocardiography represents the primary diagnostic modality for assessment of MVP. Accurate quantitation of ventricular volumes and function for surgical planning in asymptomatic severe MR can be provided with both echocardiography and cardiac magnetic resonance ...
November 6, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29121719/implantable-cardioverter-defibrillator-therapy-in-repaired-tetralogy-of-fallot-after-pulmonary-valve-replacement-implications-for-the-mechanism-of-ventricular-arrhythmia
#19
Shuenn-Nan Chiu, Shu-Chien Huang, Jou-Kou Wang, Chun-Wei Lu, Ling-Yin Chang, Ming-Tai Lin, Chun-An Chen, Yih-Sharng Chen, Mei-Hwan Wu
BACKGROUND: Ventricular tachycardia (VT), which is related to haemodynamic and electrophysiological alterations, is an important complication in repaired tetralogy of Fallot (rTOF) patients. We defined the role of implantable cardioverter defibrillator (ICD) therapy after pulmonary valve replacement (PVR) and the implications of coexisting long QT gene mutations/polymorphisms. METHODS: From 2003 to 2016, rTOF patients with VT who received ICD implantation were enrolled...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29119728/a-framework-for-designing-patient-specific-bioprosthetic-heart-valves-using-immersogeometric-fluid-structure-interaction-analysis
#20
Fei Xu, Simone Morganti, Rana Zakerzadeh, David Kamensky, Ferdinando Auricchio, Alessandro Reali, Thomas J R Hughes, Michael S Sacks, Ming-Chen Hsu
Numerous studies have suggested that medical image derived computational mechanics models could be developed to reduce mortality and morbidity due to cardiovascular diseases by allowing for patient-specific surgical planning and customized medical device design. In this work, we present a novel framework for designing prosthetic heart valves using a parametric design platform and immersogeometric fluid-structure interaction (FSI) analysis. We parameterize the leaflet geometry using several key design parameters...
November 9, 2017: International Journal for Numerical Methods in Biomedical Engineering
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