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Lipid guidelines

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https://www.readbyqxmd.com/read/29447742/a-comparative-analysis-of-current-lipid-treatment-guidelines-nothing-stands-still
#1
REVIEW
Anjan Tibrewala, Arif Jivan, William J Oetgen, Neil J Stone
Lipid treatment guidelines have continued to evolve as new evidence emerges. We sought to review similarities and differences of 5 lipid treatment guidelines from the American College of Cardiology/American Heart Association, Canadian Cardiovascular Society, European Society for Cardiology/European Atherosclerosis Society, U.S. Preventive Services Task Force, and U.S. Veterans Affairs/Department of Defense. All guidelines utilize rigorous evidentiary review, highlight statin therapy for primary and secondary prevention of atherosclerotic cardiovascular disease, and emphasize a clinician-patient risk discussion...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29440909/clinical-characteristics-patterns-of-lipid-lowering-medication-use-and-health-care-resource-utilization-and-costs-among-patients-with-atherosclerotic-cardiovascular-disease
#2
Thomas P Power, Xuehua Ke, Zhenxiang Zhao, Nicole Gidaya Bonine, Mark J Cziraky, Michael Grabner, John J Barron, Ralph Quimbo, Burkhard Vangerow, Peter P Toth
Purpose: The aim of this study was to investigate real-world patient characteristics, medication use, and health care resource utilization (HCRU) and costs among patients with clinical atherosclerotic cardiovascular disease (ASCVD) as defined by 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, to examine burden of disease and unmet needs, such as potential undertreatment. Patients and methods: This retrospective cohort study utilized a nationally representative managed care database to identify newly diagnosed ASCVD patients between January 1, 2007, and November 30, 2012 (index = first ASCVD diagnosis date) in the USA...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29432601/surf-copd-the-recording-of-cardiovascular-risk-in-patients-with-chronic-lung-disease
#3
A Dudina, S Lane, M Butler, M-T Cooney, I Graham
Background: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic obstructive pulmonary disease (COPD) and such patients tend to carry a heavy burden of risk factors for CVD. There is little information on the documentation and management of CVD risk factors in COPD patients. Aim: To audit the recording and management of CVD risk factors in 200 COPD patients attending the respiratory out-patient clinics at two University teaching hospitals...
February 8, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29427978/spatial-and-temporal-impacts-of-the-skjerv%C3%A3-y-harbour-diesel-spill-on-native-population-of-blue-mussels-a-sub-arctic-case-study
#4
Marine Breitwieser, Hélène Thomas-Guyon, Valérie Huet, Kjetil Sagerup, Perrine Geraudie
This work was designed to investigate biological impacts on blue mussels (Mytilus edulis spp) after being exposed to diesel spill. On December 2013, an 180,000-litre accidental acute diesel spill was reported in a small harbour of northern Norway (Skjervøy). In order to assess the biological effects on the wild population of blue mussels, bivalves were collected at three different locations: at the oil-spill spot, at the other side of the harbour (opposite the oil-spill area), and in an uncontaminated site...
February 7, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29413998/lipid-lowering-treatment-in-peripheral-artery-disease
#5
REVIEW
Niki Katsiki, Athanasios D Giannoukas, Vasilios G Athyros, Dimitri P Mikhailidis
Peripheral artery disease (PAD) is characterized by increased cardiovascular (CV) risk, limb morbidity and all-cause mortality. According to the current guidelines (2016) of the American Heart Association/American College of Cardiology on the management of PAD patients, statin therapy is recommended for PAD patients in order to treat dyslipidemia and reduce CV risk. The present narrative review discusses the use of statins and other lipid-lowering drugs such as ezetimibe, fibrates, niacin, anacetrapib and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in PAD patients in terms of both CV and limb outcomes...
January 31, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29410551/association-between-occupational-lead-exposure-and-plasma-levels-of-selected-oxidative-stress-related-parameters-in-jordanian-automobile-workers
#6
Ziad Shraideh, Darwish Badran, Abdelrahim Hunaiti, Abdelkader Battah
OBJECTIVES: To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. MATERIAL AND METHODS: Blood lead levels were determined for a total of 90 male automobile workers aged within the range of 25-45 years old along with the group of 20 agematched healthy males control. To get an idea about the antioxidant status of controls and lead-exposed workers, and to estimate the oxidative stress caused by exposure to lead, we measured the hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentration, superoxide dismutase (SOD) activity, lipid peroxidation as malondialdehyde (MDA) and total antioxidant capacity of controls and workers...
January 8, 2018: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29406430/abacavir-lamivudine-and-tenofovir-emtricitabine-in-pregnant-women-with-hiv-laboratory-and-clinical-outcomes-in-an-observational-national-study
#7
Marco Floridia, Carmela Pinnetti, Marina Ravizza, Giulia Masuelli, Carlo Personeni, Matilde Sansone, Anna Degli Antoni, Giovanni Guaraldi, Arsenio Spinillo, Beatrice Tassis, Serena Dalzero, Giuseppina Liuzzi, Enrica Tamburrini
BACKGROUND: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational study. METHODS: Laboratory measures (CD4, HIV-RNA, lipid profile, glucose, haemoglobin, ALT) and pregnancy outcomes (preterm delivery, low birthweight, nonelective cesarean section, birthweight Z-score, congenital defects, HIV transmission, maternal weight gain, pregnancy complications) were compared following prenatal exposure to ABC/3TC or TDF/FTC...
February 5, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29402522/a-phase-iii-multicenter-randomized-double-blind-active-comparator-clinical-trial-to-compare-the-efficacy-and-safety-of-combination-therapy-with-ezetimibe-and-rosuvastatin-versus-rosuvastatin-monotherapy-in-patients-with-hypercholesterolemia-i-rosette-ildong
#8
Soon Jun Hong, Han Saem Jeong, Jeong Cheon Ahn, Dong-Hun Cha, Kyung Heon Won, Weon Kim, Sang Kyoon Cho, Seok-Yeon Kim, Byung-Su Yoo, Ki Chul Sung, Seung-Woon Rha, Joon-Han Shin, Kyoo Rok Han, Wook Sung Chung, Min Su Hyon, Han Cheol Lee, Jang-Ho Bae, Moo-Yong Rhee, Jun Kwan, Dong Woon Jeon, Ki Dong Yoo, Hyo-Soo Kim
PURPOSE: Combination therapy with ezetimibe and statins is recommended in cases of statin intolerance or insufficiency. The objective of this study was to compare the efficacy and safety of combination therapy with ezetimibe and rosuvastatin versus those of rosuvastatin monotherapy in patients with hypercholesterolemia. METHODS: I-ROSETTE (Ildong ROSuvastatin & ezETimibe for hypercholesTElolemia) was an 8-week, double-blind, multicenter, Phase III randomized controlled trial conducted at 20 hospitals in the Republic of Korea...
February 2, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29402273/in-vitro-assessment-of-nutraceutical-compounds-and-novel-nutraceutical-formulations-in-a-liver-steatosis-based-model
#9
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi
BACKGROUND: Steatosis is a chronic liver disease that depends on the accumulation of intracellular fatty acids. Currently, no drug treatment has been licensed for steatosis; thus, only nutritional guidelines are indicated to reduce its progression. The aim of this study is to combine different nutraceutical compounds in order to evaluate their synergistic effects on a steatosis in vitro model compared to their separate use. In particular, three different formulations based on silymarin, curcumin, vitamin E, docosahexaenoic acid (DHA), choline, and phosphatidylcholine were assayed...
February 5, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29401328/implications-of-new-cholesterol-treatment-guidelines-on-statin-utilization-intensity-and-costs-in-active-duty-service-members
#10
Michael S Cahill, Rebecca M Seifried, Julia H Cheringal, Nicholas R Fiacco, Patrick S Moon, Michael K Cheezum, Todd C Villines
Background: The recommendations in the 2013 American College of Cardiology/American Heart Association (ACC/AHA) blood cholesterol guidelines expanded the indications and level of intensity of statin therapy for the primary prevention of cardiovascular disease. We assessed the treatment and cost implications of theseguidelines within a cohort of active duty service members. Methods: Using the military electronic medical record system, the Armed Forces Health Longitudinal Technology Application, we randomly selected 1,000 active duty persons aged 40 yr or older and reviewed their lipid profiles and medical records to identify risk factors for atherosclerotic cardiovascular disease...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29399756/cardiovascular-risk-assessment-cardiovascular-disease-risk-factors-and-lung-function-parameters
#11
Maciej Polak, Agnieszka Doryńska, Krystyna Szafraniec, Andrzej Pająk
BACKGROUND: Decreased lung function is related to higher cardiovascular disease (CVD) incidence and mortality. However, little is known about the relationship between the risk factors of CVD and pulmonary function. AIM: To assess the relationship between the prevalence of cardiovascular risk factors, the total CVD risk and pulmonary function. METHODS: The analysis included 4,104 men and women in the age range of 45-69 years, participants of the Polish part of the HAPIEE Project (Health,Alcohol andPsychosocial factorsInEasternEurope), who provided valid measurements of 1s forced expiratory volume (FEV₁) and forced vital capacity (FVC) using Micro-Medical Microplus spirometer...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29399299/self-management-levels-of-diet-and-metabolic-risk-factors-according-to-disease-duration-in-patients-with-type-2-diabetes
#12
Sukyung Cho, Minkyeong Kim, Kyong Park
BACKGROUND/OBJECTIVES: Metabolic risk factors should be managed effectively in patients with type 2 diabetes mellitus (T2DM) to prevent or delay diabetic complications. This study aimed to compare the self-management levels of diet and metabolic risk factors in patients with T2DM, according to the duration of illness, and to examine the trends in self-management levels during the recent decades. SUBJECTS/METHODS: Data were collected from the Korea National Health and Nutrition Examination Surveys (KNHANES, 1998-2014)...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29398635/association-of-vitamin-d-status-with-metabolic-syndrome-and-its-components-a-cross-sectional-study-in-a-population-of-high-educated-iranian-adults
#13
Masoume Mansouri, Roshanak Abasi, Morteza Nasiri, Farshad Sharifi, Sedyghe Vesaly, Omid Sadeghi, Nayere Rahimi, Nasrin Akbary Sharif
AIM: We aimed to assess the association of vitamin D status with metabolic syndrome and its components among high educated Iranian adults. METHOD: In this cross-sectional study, 352 faculty members with age of 35 years or more, belong to Tarbiat Modares University, Tehran, Islamic Republic of Iran, were recruited during 2016 and 2017. Fasting blood samples were obtained to quantify serum 25(OH)D concentrations, glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III)...
February 1, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29395184/management-of-hypertension-and-high-low-density-lipoprotein-in-pediatric-type-1-diabetes
#14
Michelle L Katz, Zijing Guo, Lori M Laffel
OBJECTIVE: To evaluate hypertension and hyperlipidemia management patterns in youth with type 1 diabetes and to assess perceived effectiveness of management strategies and barriers to management. STUDY DESIGN: An electronic survey, including clinical scenarios, fielded to pediatric providers (members of the American Diabetes Association Diabetes in Youth Interest Group, Pediatric Endocrine Society, or T1D Exchange). RESULTS: Respondents (N = 207, 86% MDs, 68% female) were practicing clinicians for youth with type 1 diabetes...
January 30, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29387889/associations-of-omega-3-fatty-acid-supplement-use-with-cardiovascular-disease-risks-meta-analysis-of-10-trials-involving-77%C3%A2-917-individuals
#15
Theingi Aung, Jim Halsey, Daan Kromhout, Hertzel C Gerstein, Roberto Marchioli, Luigi Tavazzi, Johanna M Geleijnse, Bernhard Rauch, Andrew Ness, Pilar Galan, Emily Y Chew, Jackie Bosch, Rory Collins, Sarah Lewington, Jane Armitage, Robert Clarke
Importance: Current guidelines advocate the use of marine-derived omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease, but large trials of omega-3 fatty acids have produced conflicting results. Objective: To conduct a meta-analysis of all large trials assessing the associations of omega-3 fatty acid supplements with the risk of fatal and nonfatal coronary heart disease and major vascular events in the full study population and prespecified subgroups...
January 31, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29387815/a-randomized-controlled-trial-to-evaluate-the-effects-of-high-protein-complete-lacto-vegetarian-pacer-diet-in-non-diabetic-obese-asian-indians-in-north-india
#16
Swati Bhardwaj, Anoop Misra, Seema Gulati, Shajith Anoop, Vineet Kumar Kamal, Ravindra Mohan Pandey
In view of the increasing prevalence of obesity in largely vegetarian Asian Indians, it is important to research a high protein, low carbohydrate vegetarian diet. The present study was designed to evaluate the effects of a "High P rotein C omplete (lacto) V E geta R ian Diet (Acronym; 'PACER diet'), on weight, body composition and metabolic profiles in non-diabetic obese Asian Indians living in north India. In this 8-week randomized control trial, 102 vegetarian subjects with body mass index (BMI) >25 kg/m 2 were randomized to either a test diet (PACER diet; high protein, high fat and moderately low carbohydrate, lacto-vegetarian diet) or control diet (standard vegetarian diet formulated as the dietary guidelines for Asian Indians) after 4 weeks of diet and exercise run-in period...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29384323/regular-egg-consumption-at-breakfast-by-japanese-woman-university-students-improves-daily-nutrient-intakes-open-labeled-observations
#17
Chie Taguchi, Yoshimi Kishimoto, Norie Suzuki-Sugihara, Emi Saita, Mika Usuda, Wei Wang, Yasunobu Masuda, Kazuo Kondo
BACKGROUND AND OBJECTIVES: Eggs, an important source of high-quality protein, contain a variety of key nutrients and antioxidants. Here we conducted an intervention study to evaluate whether the additional consumption of one egg per day would affect the daily nutritional intakes and blood antioxidant status in Japanese woman university students. METHODS AND STUDY DESIGN: For 4 weeks, the 14 subjects were provided a nutritious breakfast including one boiled egg, and they were asked to keep a daily dietary record...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29374939/-comparison-of-arterial-stiffness-in-non-hypertensive-and-hypertensive-population-of-various-age-groups
#18
Y J Zhang, S L Wu, H Y Li, Q H Zhao, C H Ning, R Y Zhang, J X Yu, W Li, S H Chen, J S Gao
Objective: To investigate the impact of blood pressure and age on arterial stiffness in general population. Methods: Participants who took part in 2010, 2012 and 2014 Kailuan health examination were included. Data of brachial ankle pulse wave velocity (baPWV) examination were analyzed. According to the WHO criteria of age, participants were divided into 3 age groups: 18-44 years group (n=11 608), 45-59 years group (n=12 757), above 60 years group (n=5 002). Participants were further divided into hypertension group and non-hypertension group according to the diagnostic criteria for hypertension (2010 Chinese guidelines for the managemengt of hypertension)...
January 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29372051/effects-of-krill-oil-and-lean-and-fatty-fish-on-cardiovascular-risk-markers-a-randomised-controlled-trial
#19
Amanda Rundblad, Kirsten B Holven, Inge Bruheim, Mari C Myhrstad, Stine M Ulven
Fish consumption and supplementation with n-3 fatty acids reduce CVD risk. Krill oil is an alternative source of marine n-3 fatty acids and few studies have investigated its health effects. Thus, we compared krill oil supplementation with the intake of fish with similar amounts of n-3 fatty acids on different cardiovascular risk markers. In an 8-week randomised parallel study, thirty-six healthy subjects aged 18-70 years with fasting serum TAG between 1·3 and 4·0 mmol/l were randomised to receive either fish, krill oil or control oil...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29371200/lipid-testing-and-statin-dosing-after-acute-myocardial-infarction
#20
William T Wang, Anne Hellkamp, Jacob A Doll, Laine Thomas, Ann Marie Navar, Gregg C Fonarow, Howard M Julien, Eric D Peterson, Tracy Y Wang
BACKGROUND: The 2013 American College of Cardiology/American Heart Association cholesterol guidelines recommend high-intensity statins for patients after myocardial infarction (MI) rather than treating to a low-density lipoprotein cholesterol goal, as the previous ATP III (Adult Treatment Panel third report) guidelines had advised. METHODS AND RESULTS: To evaluate the frequency of postdischarge lipid testing and high-intensity statin use among MI patients discharged on a statin during the ATP III guidelines era, we linked ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry data to Medicare claims for 11 046 MI patients aged ≥65 years who were discharged alive on a statin from 347 hospitals (2007-2009)...
January 25, 2018: Journal of the American Heart Association
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