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Lipid guidelines

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https://www.readbyqxmd.com/read/29035883/association-between-allergies-and-hypercholesterolemia-a-systematic-review
#1
Sara Manti, Caterina Cuppari, Lucia Marseglia, Gabriella D'Angelo, Teresa Arrigo, Eloisa Gitto, Salvatore Leonardi, Carmelo Salpietro
BACKGROUND: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. METHODS: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations...
October 17, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29030727/-parenteral-nutrition-in-premature-babies-with-a-birth-weight-1500g-a%C3%A2-systematic-single-center-analysis-and-comparison-with-current-guidelines
#2
Melanie Sirch, Martin Poryo, Mona Butte, Ulrike Lindner, Ludwig Gortner, Michael Zemlin, Holger Nunold, Sascha Meyer
BACKGROUND: Parenteral and enteral nutrition are essential for both growth and development of preterm infants. Based on the results of many studies, the rate of nutritional growth and the amount of substrate delivered parenterally are under debate. OBJECTIVE: The main aim of this study was to assess parenteral nutrition in very and extremely immature preterm infants, i.e. very low birth weight (VLBW, birth weight <1500g) and extremely low birth weight (ELBW, birth weight <1000g) neonates, and to compare the amount of parenterally delivered substrate in our neonatal intensive care unit (NICU) to current German guidelines...
October 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29030660/tofacitinib-improves-atherosclerosis-despite-up-regulating-serum-cholesterol-in-patients-with-active-rheumatoid-arthritis-a-cohort-study
#3
Kensuke Kume, Kanzo Amano, Susumu Yamada, Toshikatsu Kanazawa, Hiroyuki Ohta, Kazuhiko Hatta, Kuniki Amano, Noriko Kuwaba
Patients with rheumatoid arthritis (RA) have an increased cardiovascular (CV) risk. This study aimed to analyze the effects of Tofacitinib treatment, a Janus kinase inhibitor, on atherosclerosis in patients with RA. Patients with an active RA (28-joint disease activity score-erythrocyte sedimentation rate > 3.2) despite methotrexate (MTX) treatment 12 mg/week were included in this open-label prospective study and started on Tofacitinib (10 mg/day, 5 mg twice/day). Japanese guideline does not allow high dose of MTX...
October 14, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29026833/primary-prevention-of-cardiovascular-disease-in-older-adults-in-china
#4
REVIEW
Jian Yong, Dong Lin, Xue-Rui Tan
Over the past two decades, the percentage of Chinese who is 60 years or older has increased from 5.2% in 1995 to 10.5% in 2015. Approximately 16% of the population in China was 60 years old and above in 2015. Since 1990, cardiovascular disease (CVD) has been the leading cause of death in China. Cardiovascular medications of older adults are usually more complicated than younger age groups due to polypharmacy, the presence of comorbidities and more susceptible to treatment-related adverse outcomes. Therefore, effective primary prevention of CVD for older adults is important in sustaining the health of older adults and reducing the burden of the healthcare system...
September 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29025360/best-practice-of-identification-and-proteomic-analysis-of-extracellular-vesicles-in-human-health-and-disease
#5
Barbara W Sódar, Árpád Kovács, Tamás Visnovitz, Éva Pállinger, Károly Vékey, Gabriella Pocsfalvi, Lilla Turiák, Edit I Buzás
Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spectrometry-based proteomics data suggest that a significant portion of human proteins are sorted into extracellular vesicles and amenable for biomarker discovery schemes. Areas covered: this review focuses on key aspects of isolation, quality control and subsequent analysis of blood plasma- and conditioned medium-derived extracellular vesicle proteins, and summarizes the current state-of-the-art in the field...
October 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29019423/national-hyperlipidemia-management-policies-improve-lipid-target-attainment-in-clinical-practice
#6
Fotios Barkas, Moses Elisaf
Hyperlipidemia is a well-established risk factor for cardiovascular disease (CVD) which is the major cause of mortality associated with a high socioeconomic burden in the developed countries. Despite the available lipid-lowering therapies, a plethora of studies have demonstrated poor lipid target attainment in clinical practice. This has been attributed mainly to the decreased patients' compliance with lipid-lowering therapy along with physicians' reluctance to prescribe more aggressive statin therapy or novel lipid-lowering drugs...
October 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29016249/factors-associated-with-obesity-and-metabolic-syndrome-in-ageing-black-south-african-women
#7
Philippe Jean-Luc Gradidge
BACKGROUND: The incidence of obesity and related metabolic diseases is high and increasing in sub-Saharan African women. Evidence on the determinants of these diseases is limited, particularly in black South African women. OBJECTIVE: This PhD review attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of ageing urban-dwelling black South African women. METHODS: Drawing on the longitudinal Birth-to-Twenty-Plus cohort, data were collected in 2002/03 and 2012/13, including information on behavioural factors (smoking, sitting time, physical activity, smokeless tobacco, and alcohol consumption), body-size perception, body composition (measures of adiposity and lean mass), blood pressure, and cardiometabolic biomarkers (lipid profile, fasting insulin, fasting blood glucose, insulin resistance, leptin, and adiponectin)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28993804/familial-hypercholesterolemia-a-systematic-review-of-guidelines-on-genetic-testing-and-patient-management
#8
Giuseppe Migliara, Valentina Baccolini, Annalisa Rosso, Elvira D'Andrea, Azzurra Massimi, Paolo Villari, Corrado De Vito
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal-dominant hereditary disorder of lipid metabolism that causes lifelong exposure to increased LDL levels resulting in premature coronary heart disease and, if untreated, death. Recent studies have shown its prevalence to be higher than previously considered, which has important implications for the mortality and morbidity of associated cardiovascular disease (CVD). Several clinical tools are used worldwide to help physicians diagnose FH, but nevertheless most patients remain undetected...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28990943/-do-turkish-reimbursement-recommendations-cover-current-european-lipid-guidelines-a-retrospective-analysis-of-patients-presenting-with-first-acute-coronary-syndrom
#9
Deniz Demirci, Duygu Ersan Demirci, Murat Esin, Özkan Kayhan, Şakir Arslan
OBJECTIVE: This study was a comparison of the statin therapy protocol issued by the European Society of Cardiology (ESC) and the Ministry of Health's Health Implementation Directive (SUT) in Turkey, performed in order to assess the adequacy of hyperlipidemia treatment indications for primary prevention. METHODS: A total of 582 patients with first acute coronary syndrome were included in the study. Patients with noncritical stenosis observed on coronary angiography or a history of atherosclerotic disease were excluded...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28990524/statins-and-inflammation-in-cardiovascular-disease
#10
Georgia Vogiatzi, Evangelos Oikonomou, Gerasimos Siasos, Sotiris Tsalamandris, Alexandros Briasoulis, Emmanuel Androulakis, George Latsios, Spyridon Papaioannou, Konstantinos Tsioufis, Dimitris Tousoulis
BACKGROUND: Chronic inflammation and immune system activation underlie a variety of seemingly unrelated cardiac conditions including not only atherosclerosis and the subsequent coronary artery disease but also peripheral artery disease, hypertension with target organ damage and heart failure. The beneficial effects of HMG-CoA reductase inhibitors or statins are mainly attributed to their ability to inhibit hepatic cholesterol biosynthesis. Beyond their lipid lowering activity, ample evidence exists in support of their potent anti-inflammatory properties which initiate from the inhibition of GTPase isoprenylation, activating a cataract of secondary pathways and extend to the inhibition and blocking of immune cell activation and interaction...
October 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28990409/hiv-primary-care-by-the-infectious-disease-physician-in-the-united-states-extending-the-continuum-of-care
#11
Seetha Lakshmi, Susan E Beekmann, Philip M Polgreen, Allan Rodriguez, Maria L Alcaide
Models of care for people living with HIV (PLWH) have varied over time due to long term survival, development of HIV-associated non-AIDS conditions, and HIV specific primary care guidelines that differ from those of the general population. The objectives of this study are to assess how often infectious disease (ID) physicians provide primary care for PLWH, assess their practice patterns and barriers in the provision of primary care. We used a 6-item survey electronically distributed to ID physician members of Emerging Infections Network (EIN)...
October 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28985560/ferroptosis-a-regulated-cell-death-nexus-linking-metabolism-redox-biology-and-disease
#12
REVIEW
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, K A Woerpel, Donna D Zhang
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28981492/an-observational-study-of-how-clinicians-use-cardiovascular-risk-assessment-to-inform-statin-prescribing-decisions
#13
Thomas Robinson, Rod Jackson, Susan Wells, Andrew Kerr, Roger Marshall
AIM: Cardiovascular disease (CVD) risk assessment is commonly recommended in guidelines, but there is uncertainty about how clinicians use this information. Our objective was to understand how New Zealand primary care clinicians use CVD risk assessment estimates to inform new statin prescribing. METHODS: We used a cohort of patients seen in primary care who have had a CVD risk estimated on the basis of a New Zealand modified Framingham risk equation. These patients were linked to national pharmaceutical dispensing records to determine new statin use in the following six months...
October 6, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28978219/epidemiology-and-management-of-hyperlipidemia
#14
Samantha Karr
Cardiovascular disease (CVD) is the leading cause of death among adults in the United States, and people with hyperlipidemia are at roughly twice the risk of developing CVD as compared to those with normal total cholesterol levels.1 Patients with familial hypercholesterolemia (FH) have an even greater risk of developing CVD at an earlier age; therefore, early detection and treatment are imperative to reduce cardiovascular events and premature death. Statins are the mainstay treatment for hyperlipidemia; however, the limitations of statins include treatment resistance, intolerance due to adverse events, and a lack of adherence which contribute to poor outcomes...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28972640/nationellt-v%C3%A3-rdprogram-f%C3%A3-r-adrenala-incidentalom-programmet-har-harmoniserats-med-europeiska-riktlinjer-%C3%A2-ger-f%C3%A3-renklad-handl%C3%A3-ggning-av-patienter
#15
Andreas Muth, Lilian Hammarstedt, Mikael Hellström, Ulf Nyman, Anders Sundin, Hans Wahrenberg, Bo Wängberg
Swedish guidelines for the management of adrenal incidentalomas  Adrenal incidentalomas are seen in about five percent of abdominal CT examinations, and in most cases represent non-hormone-producing adrenocortical adenomas, but hormone-producing or malignant lesions occur. Revised Swedish guidelines for the evaluation and management of adrenal incidentalomas based on recently published European guidelines are presented. The importance of a thorough radiological, clinical and biochemical initial evaluation is emphasized...
September 29, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28960806/regional-evidence-and-international-recommendations-to-guide-lipid-management-in-asian-patients-with-type-2-diabetes-with-special-reference-to-renal-dysfunction
#16
REVIEW
Titus Wl Lau, Kevin Ek Tan, Jason Cj Choo, T G Ng, Tavintharan S, Juliana C N Chan
The anticipated increase in the prevalence and incidence of type 2 diabetes in Asia, and its associated cardiovascular-renal complications will place a significant burden on patients, caregivers and society. Despite the proven effectiveness of lipid management in reducing these complications, there are major treatment gaps especially in Asian patients with young-onset diabetes and chronic kidney disease. Recent international guidelines recommended the adoption of absolute risk estimation of atherosclerosis and cardiovascular disease to guide treatment intensity...
September 28, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28958912/in-chemico-in%C3%A2-vitro-and-in%C3%A2-vivo-comparison-of-the-skin-sensitizing-potential-of-eight-unsaturated-and-one-saturated-lipid-compounds
#17
Reinhard Kreiling, Helge Gehrke, Thomas H Broschard, Birte Dreeßen, Dorothea Eigler, David Hart, Veronika Höpflinger, Marcus Kleber, Joanna Kupny, Qiang Li, Peter Ungeheuer, Ursula G Sauer
The applicability of the Direct Peptide Reactivity Assay (DPRA), the KeratinoSens™ assay and the human cell line activation test (OECD Test Guidelines 442C, 442D, 442E) in predicting the skin sensitising potential of nine lipid (bio)chemicals was investigated. The results from the three assays were integrated using a published prediction model (PM), by which skin sensitisation is predicted if at least two of the three assays yield positive results. Of the eight test substances that were classified as non-sensitisers using available Guinea Pig Maximisation Test (GPMT) data, only five were correctly predicted as 'negative' in the PM...
September 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28950823/statins-in-peripheral-arterial-disease
#18
Scott T Chiesa, Nikos Papageorgiou, Marietta Charakida
Peripheral arterial disease (PAD) is a common atherosclerotic condition affecting the lower extremities. PAD patients share similar cardiovascular risk factors to coronary artery disease patients and suffer from increased cardiovascular morbidity and mortality. Statins have been widely used in coronary artery disease patients but have been underused in patients with PAD. In the current review, we present data, which support the beneficial role of statins in both reducing cardiovascular events and improving symptom-related outcomes in PAD patients...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28946607/prospective-study-of-nut-consumption-and-incidence-of-metabolic-syndrome-tehran-lipid-and-glucose-study
#19
Somayeh Hosseinpour-Niazi, Shabnam Hosseini, Parvin Mirmiran, Fereidoun Azizi
This study aimed to assess the association of various types of nut per se, and total nut consumption with the incidence of metabolic syndrome (MetS). A 6.2 ± 0.7-year population-based prospective study was conducted among 1265 adults, aged 19-74 years, participants of the Tehran Lipid and Glucose Study. A 168-item semi-quantitative food frequency questionnaire was used to collect information on nut consumption. MetS was defined according to the Joint Interim Statement guidelines and 276 new cases of MetS were identified...
September 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28942754/can-we-improve-the-nutritional-quality-of-meat
#20
Nigel D Scollan, Eleri M Price, Sarah A Morgan, Sharon A Huws, Kevin J Shingfield
The nutritional value of meat is an increasingly important factor influencing consumer preferences for poultry, red meat and processed meat products. Intramuscular fat content and composition, in addition to high quality protein, trace minerals and vitamins are important determinants of nutritional value. Fat content of meat at retail has decreased substantially over the past 40 years through advances in animal genetics, nutrition and management and changes in processing techniques. Evidence of the association between diet and the incidence of human non-communicable diseases has driven an interest in developing production systems for lowering total SFA and trans fatty acid (TFA) content and enrichment of n-3 PUFA concentrations in meat and meat products...
September 25, 2017: Proceedings of the Nutrition Society
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