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Lipid guidelines

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https://www.readbyqxmd.com/read/29221862/physical-activity-sedentary-time-tv-viewing-physical-fitness-and-cardiovascular-disease-risk-in-adolescents-the-helena-study
#1
Alan R Barker, Luis Gracia-Marco, Jonatan R Ruiz, Manuel J Castillo, Raquel Aparicio-Ugarriza, Marcela González-Gross, Anthony Kafatos, Odysseas Androutsos, Angela Polito, Dénes Molnar, Kurt Widhalm, Luis A Moreno
BACKGROUND: To examine the independent associations between physical activity (PA) intensities, sedentary time (ST), TV viewing, cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiovascular disease (CVD) risk in youth. METHODS: A cross-sectional study on 534 European adolescents (252 males, 282 females, 12.5-17.5years). Minutes per day of light (LPA), moderate (MPA) and vigorous (VPA) PA and total ST were measured using accelerometers. TV viewing time was measured using a questionnaire...
November 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29218464/microalgae-lipid-staining-with-fluorescent-bodipy-dye
#2
Judita Koreivienė
The staining of lipids in algae cells with BODIPY dyes is much less studied compared to Nile red; therefore, a complex of issues concerning staining details and fluorescence measurements still should be clarified for the species that vary in cell wall complexity. Nevertheless, some general guidelines could be given, and a preliminary protocol of the method is provided based on the existing data. The semiquantification of lipid could be reliable if the staining protocol will be developed and adapted for particular microalgae species...
December 8, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29215632/assembly-of-phospholipid-nanodiscs-of-controlled-size-for-structural-studies-of-membrane-proteins-by-nmr
#3
Franz Hagn, Mahmoud L Nasr, Gerhard Wagner
Suitable membrane mimetics are crucial to the performance of structural and functional studies of membrane proteins. Phospholipid nanodiscs (formed when a membrane scaffold protein encircles a small portion of a lipid bilayer) have native-like membrane properties. These have been used for a variety of functional studies, but structural studies by high-resolution solution-state NMR spectroscopy of membrane proteins in commonly used nanodiscs of 10-nm diameter were limited by the high molecular weight of these particles, which caused unfavorably large NMR line widths...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29214863/impact-of-a-weight-management-intervention-on-eating-competence-importance-of-measurement-interval-in-protocol-design
#4
Barbara Lohse, Jodi Stotts Krall, Tricia Psota, Penny Kris-Etherton
PURPOSE: To examine changes in eating competence (EC) in 12-month weight loss intervention. DESIGN: Randomized, parallel-arm with weight loss phase (baseline to month 4) and weight-maintenance phase (months 4-12). SETTING: Face-to-face in University classrooms, supervised and self-directed fitness sessions at University fitness center, and home. PARTICIPANTS: Premenopausal, mostly college-educated Pennsylvania women, body mass index >25 (n = 101)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29212812/pharmacologic-prevention-of-incident-atrial-fibrillation-long-term-results-from-the-allhat-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial
#5
Thomas A Dewland, Elsayed Z Soliman, Jose-Miguel Yamal, Barry R Davis, Alvaro Alonso, Christine M Albert, Lara M Simpson, L Julian Haywood, Gregory M Marcus
BACKGROUND: Although atrial fibrillation (AF) guidelines indicate that pharmacological blockade of the renin-angiotensin system may be considered for primary AF prevention in hypertensive patients, previous studies have yielded conflicting results. We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance. METHODS AND RESULTS: We performed a secondary analysis of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive individuals ≥55 years of age with at least one other cardiovascular risk factor...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29209441/pcsk9-signaling-pathways-and-their-potential-importance-in-clinical-practice
#6
REVIEW
Michał Wiciński, Jarosław Żak, Bartosz Malinowski, Gabriela Popek, Grzegorz Grześk
In the following review, authors described the structure and biochemical pathways of PCSK9, its involvement in LDL metabolism, as well as significances of proprotein convertase subtilisin/kexin type 9 targeted treatment. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. Transcription and translation of PCSK9 is controlled by different nuclear factors, such as, SREBP and HNF1α. This review focuses on interactions between PCSK9 and LDL receptor, VLDLR, ApoER2, CD36, CD81, and others...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29204335/temporal-trends-in-lipid-testing-among-children-and-adolescents-a-population-based-study
#7
Swetha Sriram, Jennifer L St Sauver, Debra J Jacobson, Chun Fan, Brian A Lynch, Valeria Cristiani, Iftikhar J Kullo, Aida N Lteif, Seema Kumar
Unfavorable lipid levels during childhood are associated with subsequent development of atherosclerotic cardiovascular disease. The American Academy of Pediatrics and National Heart, Lung and Blood Institute in 2011 recommended universal lipid screening for children between ages 9-11 years and between ages 17-21 years. The objective of the study was to determine temporal trends in lipid testing among children and young adults in a mid-western population. The Rochester Epidemiology Project database was used to identify lipid testing in ages 2-21 years (n = 51,176) in the Olmsted County population from January 1, 2008 through December 31, 2014...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29204050/current-and-emerging-pharmacological-therapy-for-non-alcoholic-fatty-liver-disease
#8
EDITORIAL
Ahad Eshraghian
The main treatment of patients with non-alcoholic fatty liver disease (NAFLD) is life style modification including weight reduction and dietary regimen. Majority of patients are safely treated with this management and pharmacologic interventions are not recommended. However, a subgroup of NAFLD patients with non-alcoholic steatohepatitis (NASH) who cannot achieve goals of life style modification may need pharmacological therapy. One major obstacle is measurement of histological outcome by liver biopsy which is an invasive method and is not recommended routinely in these patients...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203343/wide-variation-in-organisation-and-clinical-practice-of-paediatric-intestinal-failure-teams-an-international-survey
#9
Esther Neelis, Barbara de Koning, Myriam van Winckel, Merit Tabbers, Susan Hill, Jessie Hulst
BACKGROUND & AIMS: We aimed to assess the current organisation and clinical practice of teams treating children with intestinal failure (IF) across Europe and compare the results with the current guideline. METHODS: A two-part online survey was sent to all the major European specialist IF services. The first part concerned general information about the team and patients monitored. The second part concerned important care topics such as vascular access and monitoring of complications...
November 22, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29197254/utilization-of-lipid-modifying-therapy-and-low-density-lipoprotein-cholesterol-goal-attainment-in-patients-at-high-and-very-high-cardiovascular-risk-real-world-evidence-from-germany
#10
Winfried März, Franz-Werner Dippel, Karlheinz Theobald, Katherine Gorcyca, Şerban R Iorga, David Ansell
BACKGROUND AND AIMS: Elevated low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for cardiovascular (CV) events. European guidelines recommend reducing LDL-C as the primary lipid target to reduce CV risk, using lifestyle modifications and lipid-lowering therapy (LLT). Many European patients do not achieve guideline-recommended LDL-C levels. The present database analysis aimed to assess LLT treatment patterns and LDL-C threshold attainment in Germany in a large, real-world cohort of patients...
November 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29194462/new-strategies-for-the-development-of-lipid-lowering-therapies-to-reduce-cardiovascular-risk
#11
Ian Graham, Chuck Shear, Pieter De Graeff, Caroline Boulton, Alberico L Catapano, Wendy Gattis Stough, Stefan C Carlsson, Guy De Backer, Joseph Emmerich, Scott Greenfeder, Albert M Kim, Dominik Lautsch, Tu Nguyen, Steven E Nissen, Krishna Prasad, Kausik Ray, Jennifer G Robinson, William J Sasiela, Karsten Bruins Slot, Erik Stroes, Tom Thuren, Bart Van der Schueren, Maja Velkovski-Rouyer, Scott M Wasserman, Olov Wiklund, Emmanouil Zouridakis
The very high occurrence of cardiovascular events presents a major public health issue because treatment remains suboptimal. Lowering low-density lipoprotein cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most interventions without evidence of attenuation or increase in risk at low LDL-C levels. Opportunities for innovation in dyslipidaemia treatment should address the substantial risk of lipid-associated cardiovascular events among patients optimally treated per guidelines but who cannot achieve LDL-C goals, could benefit from additional LDL-C lowering therapy, or experience side effects of statins...
November 28, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29191431/epidemiological-characteristics-of-lower-extremity-arterial-disease-in-chinese-diabetes-patients-at-high-risk-a-prospective-multicenter-cross-sectional-study
#12
Xiaomei Zhang, Xingwu Ran, Zhangrong Xu, Zhifeng Cheng, Feixia Shen, Yanmei Yu, Lin Gao, Sanbo Chai, Changjiang Wang, Jianying Liu, Jing Liu, Zilin Sun, Jiajun Zhao, Linong Ji
AIMS: To determine the epidemiological characteristics of lower extremity arterial disease (LEAD) in high-risk patients and identify practical gaps in LEAD management. METHODS: This cross-sectional study consecutively enrolled 10681 patients with type 2 diabetes from 30 hospitals across China from June 2016 to January 2017. All patients were assessed for LEAD by the Ankle-Brachial Index in conjunction with lower limb ultrasonography according to local guidelines...
October 13, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29180296/universal-lipid-screening-in-9-11-year-olds-before-and-after-2011-guidelines
#13
Nicole L Mihalopoulos, Carole Stipelman, Joni Hemond, Laura L Brown, Paul C Young
OBJECTIVE: To determine whether the 2011 guidelines for universal routine screening for dyslipidemia in children aged 9 to 11 years, published by the Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents and National Heart, Lung, and Blood Institute, are being followed by pediatric primary care providers. STUDY DESIGN: Retrospective data were obtained for 63,951 well-child visits (WCV) in children aged 9 to 11 years from two health care systems and one insurance program from 2009 to 2015...
November 24, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29176758/early-optimal-parenteral-nutrition-and-metabolic-acidosis-in-very-preterm-infants
#14
Francesco Bonsante, Jean-Bernard Gouyon, Pierre-Yves Robillard, Béatrice Gouyon, Silvia Iacobelli
BACKGROUND: It is currently recognized that an optimized nutritional approach, consisting of an early and substantial supply of protein and energy by parenteral route, may be beneficial for very low birth weight infants and recent guidelines endorse this strategy. However, the impact of the enhanced parenteral nutrition (PN) on acid-basic balance has never been investigated. The aim of the present study is to assess the effect of nutrient intake on acid-base homeostasis in a large population of preterm infants on PN...
2017: PloS One
https://www.readbyqxmd.com/read/29176657/dyslipidaemia-in-nephrotic-syndrome-mechanisms-and-treatment
#15
REVIEW
Shipra Agrawal, Joshua J Zaritsky, Alessia Fornoni, William E Smoyer
Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity despite notable advances in its treatment. Many of the complications of nephrotic syndrome, including the increased risk of atherosclerosis and thromboembolism, can be linked to dysregulated lipid metabolism and dyslipidaemia. These abnormalities include elevated plasma levels of cholesterol, triglycerides and the apolipoprotein B-containing lipoproteins VLDL and IDL; decreased lipoprotein lipase activity in the endothelium, muscle and adipose tissues; decreased hepatic lipase activity; and increased levels of the enzyme PCSK9...
November 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29173300/persistent-high-non-high-density-lipoprotein-cholesterol-in-early-childhood-a-latent-class-growth-model-analysis
#16
Jordan M Albaum, Sarah Carsley, Yang Chen, David W H Dai, Gerald Lebovic, Brian W McCrindle, Jonathon L Maguire, Patricia C Parkin, Catherine S Birken
OBJECTIVES: To examine patterns of non-high-density lipoprotein (HDL) cholesterol in early childhood and identify factors associated with persistent high non-HDL cholesterol in healthy urban children. STUDY DESIGN: We identified all children enrolled in a primary care practice-based research network called TARGet Kids! (The Applied Research Group for Kids) with ≥3 laboratory measurements of non-HDL cholesterol. Latent class growth model analysis was performed to identify distinct trajectory groups for non-HDL cholesterol...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29172973/ezetimibe-use-and-ldl-c-goal-achievement-a-retrospective-database-analysis-of-patients-with-clinical-atherosclerotic-cardiovascular-disease-or-probable-heterozygous-familial-hypercholesterolemia
#17
Joseph Menzin, Jyoti Aggarwal, Brian Boatman, Jeffrey Yu, Kevin Stern, David J Harrison, Jeetvan G Patel
BACKGROUND: Ezetimibe is recommended by clinical practice guidelines as a second-line therapy for lowering low-density lipoprotein cholesterol (LDL-C) levels, but little is known about its use and effectiveness in real-world populations. OBJECTIVE: To understand the real-world impact of adding or switching to ezetimibe on LDL-C goal achievement in patients with clinical atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH)...
December 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29172726/association-between-serum-osteocalcin-level-and-blood-pressure-in-a-chinese-population
#18
Yiting Xu, Xiaojing Ma, Qin Xiong, Xiang Hu, Xueli Zhang, Yeqing Yuan, Yuqian Bao
PURPOSE: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population. MATERIALS AND METHODS: A total of 2241 subjects (909 men and 1,332 women; age, 24-78 years) from Shanghai communities were recruited. Subjects were divided into non-hypertensive and hypertensive groups according to diagnosis of hypertension based on the 1999 World Health Organization-International Society of Hypertension Guidelines...
November 27, 2017: Blood Pressure
https://www.readbyqxmd.com/read/29171772/assessing-gaps-in-cholesterol-treatment-guidelines-for-primary-prevention-of-cardiovascular-disease-based-on-available-randomised-clinical-trial-evidence-the-rotterdam-study
#19
Jelena Pavlović, Philip Greenland, Jaap W Deckers, Maryam Kavousi, Albert Hofman, M Arfan Ikram, Oscar H Franco, Maarten Jg Leening
Background The purpose of this study was to determine how American College of Cardiology/American Heart Association (ACC/AHA) 2013 and European Society of Cardiology 2016 guidelines for the primary prevention of atherosclerotic cardiovascular disease (CVD) compare in reflecting the totality of accrued randomised clinical trial evidence for statin treatment at population level. Methods From 1997-2008, 7279 participants aged 45-75 years, free of atherosclerotic cardiovascular disease, from the population-based Rotterdam Study were included...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29171360/canadian-stroke-best-practice-consensus-statement-secondary-stroke-prevention-during-pregnancy
#20
Richard H Swartz, Noor Niyar N Ladhani, Norine Foley, Kara Nerenberg, Simerpreet Bal, Jon Barrett, Cheryl Bushnell, Wee-Shian Chan, Radha Chari, Dariush Dowlatshahi, Meryem El Amrani, Shital Gandhi, Gord Gubitz, Michael D Hill, Andra James, Thomas Jeerakathil, Albert Jin, Adam Kirton, Sylvain Lanthier, Andrea Lausman, Lisa Rae Leffert, Jennifer Mandzia, Bijoy Menon, Aleksandra Pikula, Alexandre Poppe, Jayson Potts, Joel Ray, Gustavo Saposnik, Mukul Sharma, Eric E Smith, Sanjit Bhogal, Elisabeth Smitko, M Patrice Lindsay
The Canadian Stroke Best Practice Consensus Statement: Secondary Stroke Prevention during Pregnancy, is the first of a two-part series devoted to stroke in pregnancy. This document focuses on unique aspects of secondary stroke prevention in a woman with a prior history of stroke or transient ischemic attack who is, or is planning to become, pregnant. Although stroke is relatively rare in this cohort, several aspects of pregnancy can increase stroke risk during or immediately after pregnancy. The rationale for the development of this consensus statement is based on the premise that stroke in this group requires a specifically-tailored management approach...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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