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Lipid guidelines

Henry Wright, Tamara Wright, Ryan T Pohlig, Scott E Kasner, Jonathan Raser-Schramm, Darcy Reisman
BACKGROUND: Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothesize that the combination of a fast walking intervention that improves walking capacity, with a step activity monitoring program that facilitates translation of gains from the clinic to the "real-world", would generate greater improvements in real world walking activity than with either intervention alone...
April 12, 2018: BMC Neurology
Tatsuya Umeda, Ai Hayashi, Akiko Harada, Kotoba Okuyama, Carl A Baxter, Shigeru Tokita, Tamio Teramoto
BACKGROUND: To understand the recent management status in Japan, we determined the low-density lipoprotein cholesterol (LDL-C) goal attainment (GA) rate of patients initiating statin monotherapy for dyslipidemia.Methods and Results:Dyslipidemic patients undergoing either primary prevention with high cardiovascular risk or secondary prevention (defined by 2012 Japan Atherosclerosis Society Guidelines) were retrospectively analyzed from a hospital-based claims database. In both groups, the LDL-C levels and GA rates of patients treated with intensive or standard statin monotherapy for ≥4 weeks (January 2012-August 2016) were evaluated...
April 7, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Mark D Danese, Eduard Sidelnikov, Lucie Kutikova
OBJECTIVE: To assess the prevalence of patients at very high risk of cardiovascular (CV) events in the United Kingdom (UK) and evaluate low-density lipoprotein cholesterol (LDL-C) values and treatment patterns in these patients. METHODS: This cross-sectional study used primary care data from UK electronic medical records in the Clinical Practice Research Datalink (CPRD) in 2013. Very high-risk patients were defined per European Society of Cardiology guidelines as those with hyperlipidemia (assessed by co-medication) and documented cardiovascular disease (CVD) or hyperlipidemia and type 2 diabetes (DM2) without CVD (DM2w/oCVD)...
April 9, 2018: Current Medical Research and Opinion
Tarekegn Geberhiwot, Alessandro Moro, Andrea Dardis, Uma Ramaswami, Sandra Sirrs, Mercedes Pineda Marfa, Marie T Vanier, Mark Walterfang, Shaun Bolton, Charlotte Dawson, Bénédicte Héron, Miriam Stampfer, Jackie Imrie, Christian Hendriksz, Paul Gissen, Ellen Crushell, Maria J Coll, Yann Nadjar, Hans Klünemann, Eugen Mengel, Martin Hrebicek, Simon A Jones, Daniel Ory, Bruno Bembi, Marc Patterson
Niemann-Pick Type C (NPC) is a progressive and life limiting autosomal recessive disorder caused by mutations in either the NPC1 or NPC2 gene. Mutations in these genes are associated with abnormal endosomal-lysosomal trafficking, resulting in the accumulation of multiple tissue specific lipids in the lysosomes. The clinical spectrum of NPC disease ranges from a neonatal rapidly progressive fatal disorder to an adult-onset chronic neurodegenerative disease. The age of onset of the first (beyond 3 months of life) neurological symptom may predict the severity of the disease and determines life expectancy...
April 6, 2018: Orphanet Journal of Rare Diseases
Katherine Black, Joanne Slater, Rachel C Brown, Rebecca Cooke
Black, K, Slater, J, Brown, RC, and Cooke, R. Low energy availability, plasma lipids, and hormonal profiles of recreational athletes. J Strength Cond Res XX(X): 000-000, 2018-It has been postulated that low energy availability (LEA) impacts bone health, hormonal concentrations, and cardiovascular function. This study describes the lipid levels, hormonal profiles, and nutrient intakes of recreationally active adults at risk of LEA compared with those not at risk. Thirty-eight women who meet or exceed the New Zealand guidelines for physical activity participated...
April 5, 2018: Journal of Strength and Conditioning Research
Thaianne Cavalcante Sérvio, Gabriela Lima de Melo Ghisi, Lilian Pinto da Silva, Luciana Duarte Novais Silva, Marcia Maria Oliveira Lima, Danielle Aparecida Gomes Pereira, Sherry L Grace, Raquel Rodrigues Britto
BACKGROUND: Cardiac rehabilitation (CR) is a recommended model of care for cardiovascular diseases; however, is not widely available and is underutilized, especially in low- and middle-income countries. OBJECTIVES: To identify the CR programs available in one Brazilian state (Minas Gerais; MG) and describe their characteristics by funding type. METHODS: In this multi-center descriptive study, CR programs were identified in four MG regions and 41 CR coordinators were sent a survey to report the characteristics of their programs, including CR components described in guidelines and barriers to patients' participation...
March 22, 2018: Brazilian Journal of Physical Therapy
Felipe Lobelo, Deborah Rohm Young, Robert Sallis, Michael D Garber, Sandra A Billinger, John Duperly, Adrian Hutber, Russell R Pate, Randal J Thomas, Michael E Widlansky, Michael V McConnell, Elizabeth A Joy
Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis...
April 4, 2018: Circulation
Hafdis Lilja Gudlaugsdottir, Arun Kristin Sigurdardottir
INTRODUCTION: Diabetes is a chronic disease often with serious and costly complications. Therefore well organised diabetes care is needed. The purpose was to research outcome of treatment on biological parameters in people with type one and two diabetes in one primary care over ten years and compare with international guidelines. MATERIAL AND METHODS: Retrospective cohort study, information was gathered from medical records at Sudurnes Health Center, in the years 2005, 2010 and 2015...
April 2018: Læknablađiđ
Angela Pirillo, Alberico Luigi Catapano
High levels of low-density lipoprotein cholesterol (LDL-C) are directly associated with an increased risk of cardiovascular disease. Reducing LDL-C levels reduces the incidence of cardiovascular events. Several lipid-lowering approaches are available to achieve the LDL-C levels recommended by current guidelines, statins being the first-line therapy. However, many patients cannot achieve the recommended LDL-C levels with current therapies. The discovery of the role of proprotein convertase subtilisin kexin 9 (PCSK9) in the regulation of plasma LDL-C levels suggested it as a potential pharmacologic target and led to the development of PCSK9 inhibitors for the management of LDL-C levels...
May 2018: Cardiology Clinics
Antoine Deschildre, Stéphanie Lejeune
PURPOSE OF REVIEW: Food allergy symptoms may involve a wide variety of organs (skin, gastrointestinal tract, and eyes) and systems (respiratory, circulatory, and neurological). They are often associated. Their severity ranges from mild to potentially life-threatening reactions and the presentation from acute to chronic. RECENT FINDINGS: Food allergies have been the focus of multiple studies, position papers, and guidelines in recent years. They have defined an approach in classifying symptoms as mild to anaphylactic, distinguishing objective from subjective symptoms, and describing their heterogeneity, specific phenotypes or syndromes (e...
March 31, 2018: Current Opinion in Allergy and Clinical Immunology
Alberto Zamora, Luís Masana, Marc Comas-Cufi, Núria Plana, Àlex Vila, Maria García-Gil, Lia Alves-Cabratosa, Roberto Elosua, Jaume Marrugat, Rafel Ramos
INTRODUCTION AND OBJECTIVES: PCSK9 inhibitors (PCSK9i) are safe and effective lipid-lowering drugs. Their main limitation is their high cost. The aim of this study was to estimate the number of patients eligible for treatment with PCSK9i according to distinct published criteria. METHODS: Data were obtained from the Information System for the Development of Research in Primary Care. Included patients were equal to or older than 18 years and had at least 1 low-density lipoprotein cholesterol measurement recorded between 2006 and 2014 (n = 2 500 907)...
March 29, 2018: Revista Española de Cardiología
Fernando H Y Cesena, Antonio G Laurinavicius, Viviane A Valente, Raquel D Conceição, Khurram Nasir, Raul D Santos, Marcio S Bittencourt
Guidelines have recommended statin initiation based on the absolute cardiovascular risk. We tested the hypothesis that a strategy based on the predicted cardiovascular benefit, compared with the risk-based approach, modifies statin eligibility and the estimated benefit in a population in primary cardiovascular prevention. The study included 16,008 subjects (48 ± 6 years, 73% men) with low-density lipoprotein cholesterol levels of 70 to <190 mg/dl, not on lipid-lowering drugs, who underwent a routine health screening in a single center...
March 1, 2018: American Journal of Cardiology
Carina Nicu, Jennifer Pople, Laura Bonsell, Ranjit Bhogal, David M Ansell, Ralf Paus
Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in cutaneous neuro-endocrinology. The ever-growing insights into DWAT functions, albeit mostly in mice, have invited speculation that it may be involved in multiple skin diseases ranging from fibrosis to alopecia and psoriasis, thus designating human DWAT a clinically relevant, but as yet insufficiently investigated skin compartment...
March 30, 2018: Experimental Dermatology
Shima Dowla, May Pendergrass, Mark Bolding, Barbara Gower, Kevin Fontaine, Ambika Ashraf, Taraneh Soleymani, Shannon Morrison, Amy Goss
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder among children in the developed world and can progress to cirrhosis, hepatocellular carcinoma, and liver failure. No evidence-based dietary guidelines exist on the most effective diet prescription to treat NAFLD. OBJECTIVE: To compare the effect of a carbohydrate (CHO)-restricted diet vs fat-restricted diet, the current standard of care, on changes in hepatic fat infiltration, body composition, and metabolic health over an 8-week period among overweight and obese children diagnosed with NAFLD...
March 27, 2018: Contemporary Clinical Trials
Beth Buchanan, Qingfang Meng, Mathieu-Marc Poulin, Jonathan Zuccolo, Chike Godwin Azike, Joseph Gabriele, David Charles Baranowski
The natural alkaloid berberine has been ascribed numerous health benefits including lipid and cholesterol reduction and improved insulin sensitivity in diabetics. However, oral (PO) administration of berberine is hindered by poor bioavailability and increasing dose often elicits gastro-intestinal side effects. To overcome the caveats associated with oral berberine, we developed transdermal (TD) formulations of berberine (BBR) and the berberine precursor dihydroberberine (DHB). These formulations were compared to oral BBR using pharmacokinetics, metabolism, and general safety studies in vivo...
2018: PloS One
Fernando H Y Cesena, Antonio Gabriele Laurinavicius, Viviane A Valente, Raquel D Conceição, Raul D Santos, Marcio S Bittencourt
BACKGROUND: Recommendations for blood cholesterol management differ across different guidelines. HYPOTHESIS: Lipid-lowering strategies based on low-density lipoprotein-cholesterol (LDL-c) percent reduction or target concentration may have different effects on the expected cardiovascular benefit in intermediate-risk individuals. METHODS: We selected individuals between 40 and 75 years of age with 10-year risk for atherosclerotic cardiovascular disease (ASCVD) between 5...
March 25, 2018: Clinical Cardiology
Jörn F Dopheide, Lucija Papac, Marc Schindewolf, Iris Baumgartner, Heinz Drexel
BACKGROUND: Patients with peripheral artery disease (PAD) are at very high risk of future cardiovascular (CV) events. Strict lipid-lowering therapy is recommended. However, data on target level attainment are scarce. OBJECTIVE: The objective of the study was to investigate guideline equitable lipid lowering in a large observational study of symptomatic PAD patients. METHODS: Single-center observational study including 1109 patients with symptomatic PAD planned for revascularization at a tertiary university center...
March 1, 2018: Journal of Clinical Lipidology
Joeri De Cloet, Stephanie Van Biervliet, Myriam Van Winckel
OBJECTIVE: Because there are almost no standard all-in-one parenteral nutrition admixtures available for infants and children, the aim was to develop standard two-compartment parenteral nutrition bags for different weight categories based on the ESPGHAN/ESPEN (European Society of Paediatric Gastroenterology, Hepatology and Nutrition/European Society for Clinical Nutrition and Metabolism) guidelines. The 1 g/kg/d lipid version for the 3 to 10 kg weight category (PED1) was assessed for short- and long-term physicochemical stability with the ability to add additional electrolytes (PED1+E)...
May 2018: Nutrition
Sundar Gnanavel, Sharafat Hussain
AIM: To ascertain performance against the standards set by National Institute for Clinical Excellence (NICE) guidelines on physical health monitoring of thirty children and adolescents prescribed antipsychotics in neurodevelopmental clinics in Northumberland and identifying areas for improvement in practice. METHODS: The audit involved a review of recorded documentation pertaining to physical health monitoring in patient electronic records pertaining to children and adolescents attending neurodevelopmental clinics in Northumberland prescribed antipsychotics...
March 22, 2018: World Journal of Psychiatry
Gulin Amasya, Mehmet Gumustas, Ulya Badilli, Sibel A Ozkan, Nilufer Tarimci
This is the first report in literature using hydrophilic interaction liquid chromatography (HILIC) in combination with diode array detector (DAD) for stability indicating determination of 5-Fluorouracil (5-FU) from its bulk form, pharmaceutical preparations, developed solid lipid nanoparticle (SLN) and nano structured lipid carrier (NLC) drug delivery systems as well as the rat skin extracts. The separation was performed at 45 °C, on Sequant Zic HILIC (250 mm × 4.60 mm ID, 5 μm, 200 Ao ), peek HPLC column...
March 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
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