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apoCIII

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https://www.readbyqxmd.com/read/28835988/vldl-and-apolipoprotein-ciii-induce-er-stress-and-inflammation-and-attenuate-insulin-signalling-via-toll-like-receptor-2-in-mouse-skeletal-muscle-cells
#1
Gaia Botteri, Marta Montori, Anna Gumà, Javier Pizarro, Lídia Cedó, Joan Carles Escolà-Gil, Diana Li, Emma Barroso, Xavier Palomer, Alison B Kohan, Manuel Vázquez-Carrera
AIM/HYPOTHESIS: Here, our aim was to examine whether VLDL and apolipoprotein (apo) CIII induce endoplasmic reticulum (ER) stress, inflammation and insulin resistance in skeletal muscle. METHODS: Studies were conducted in mouse C2C12 myotubes, isolated skeletal muscle and skeletal muscle from transgenic mice overexpressing apoCIII. RESULTS: C2C12 myotubes exposed to VLDL showed increased levels of ER stress and inflammatory markers whereas peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and AMP-activated protein kinase (AMPK) levels were reduced and the insulin signalling pathway was attenuated...
August 23, 2017: Diabetologia
https://www.readbyqxmd.com/read/28647101/the-role-of-hypertriglyceridemia-for-acute-kidney-injury-in-the-course-of-acute-pancreatitis-and-an-animal-model
#2
Congye Wu, Lei Zou, Shujing Shi, Zhihui Tong, Xiao Shen, Dongliang Yang, Lu Ke, Weiqin Li, Jieshou Li
OBJECTIVE: The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. METHODS: Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments...
July 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28643274/an-unexplained-congenital-disorder-of-glycosylation-ii-in-a-child-with-neurohepatic-involvement-hypercholesterolemia-and-hypoceruloplasminemia
#3
Pier Luigi Calvo, Marco Spada, Ivana Rabbone, Michele Pinon, Francesco Porta, Fabio Cisarò, Stefania Reggiani, Angelo B Cefalù, Luisella Sturiale, Domenico Garozzo, Dirk J Lefeber, Jaak Jaeken
We report on a 12-year-old adopted boy with psychomotor disability, absence seizures, and normal brain MRI. He showed increased (but initially, at 5 months, normal) serum cholesterol, increased alkaline phosphatases, transiently increased transaminases and hypoceruloplasminemia with normal serum and urinary copper. Blood levels of immunoglobulins, haptoglobin, antithrombin, and factor XI were normal. A type 2 serum transferrin isoelectrofocusing and hypoglycosylation of apoCIII pointed to a combined N- and O-glycosylation defect...
June 23, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28539597/apociii-enrichment-in-hdl-impairs-hdl-mediated-cholesterol-efflux-capacity
#4
Mengdie Luo, Aiying Liu, Shuai Wang, Tianle Wang, Die Hu, Sha Wu, Daoquan Peng
Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However, the effect of apoCIII on HDL-mediated cholesterol efflux, the crucial function of HDL, has not been reported. A hospital-based case-control study was conducted to compare the apoCIII distribution in lipoproteins between CAD patients and nonCAD controls and to explore the relationship between HDL-associated apoCIII (apoCIIIHDL) and HDL-mediated cholesterol efflux...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261635/association-of-serum-lipids-and-coronary-artery-disease-with-polymorphisms-in-the-apolipoprotein-ai-ciii-aiv-gene-cluster
#5
Himanshu Rai, Nakul Sinha, James Finn, Suraksha Agrawal, Sarabjit Mastana
Genetic variants are considered as one of the main determinants of the concentration of serum lipids and coronary artery disease (CAD). Polymorphisms in the Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect the concentrations of various lipid sub-fractions and the risk of CAD. The present study assessed associations between polymorphisms of the Apo AI-CIII-AIV gene cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C > G, (SstI), (rs5128) and ApoA-IV, Thr347Ser(347A > T), (rs675)] with serum lipids and their contributions to CAD in North Indian population...
December 31, 2016: Cogent Medicine
https://www.readbyqxmd.com/read/28245894/plasma-apociii-levels-in-relation-to-inflammatory-traits-and-metabolic-syndrome-in-patients-not-treated-with-lipid-lowering-drugs-undergoing-coronary-angiography
#6
Na Qiong Wu, Sha Li, Yan Zhang, Cheng Gang Zhu, Yuan Lin Guo, Ying Gao, Ping Qing, Jing Sun, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Assessment of the comprehensive relationship among apolipoprotein CIII (apoCIII) levels, inflammation, and metabolic disorders is rare. METHODS: A total of 1455 consecutive patients not treated with lipid-lowering drugs and undergoing coronary angiography were enrolled in this cross-sectional study. A mediation analysis was used to detect the underlying role of apoCIII in the association of inflammation with metabolic syndrome (MetS). RESULTS: Patients with MetS showed higher levels of apoCIII [95...
January 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28163820/apolipoprotein-ciii-overexpression-induced-hypertriglyceridemia-increases-nonalcoholic-fatty-liver-disease-in-association-with-inflammation-and-cell-death
#7
Adriene A Paiva, Helena F Raposo, Amarylis C B A Wanschel, Tarlliza R Nardelli, Helena C F Oliveira
Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of a high-fat diet (HFD), produces NAFLD-like features, including increased liver lipid content; decreased antioxidant power; increased expression of TNFα, TNFα receptor, cleaved caspase-1, and interleukin-1β; decreased expression of adiponectin receptor-2; and increased cell death...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28031419/serum-levels-of-apolipoproteins-and-incident-type-2-diabetes-a-prospective-cohort-study
#8
Adela Brahimaj, Symen Ligthart, M Arfan Ikram, Albert Hofman, Oscar H Franco, Eric J G Sijbrands, Maryam Kavousi, Abbas Dehghan
OBJECTIVE: We aimed to investigate the role of serum levels of various apolipoproteins on the risk for type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We used data from 971 individuals from the prospective population-based Rotterdam Study. We studied the association of HDL cholesterol (HDL-C), apoA1, apoCIII, apoD, and apoE as well as the ratios of apolipoproteins with apoA1 with the risk of T2D. All apolipoproteins, ratios, and HDL-C levels were naturally log-transformed to reach normal distribution...
March 2017: Diabetes Care
https://www.readbyqxmd.com/read/27919362/the-effect-of-omega-3-carboxylic-acids-on-apolipoprotein-ciii-containing-lipoproteins-in-severe-hypertriglyceridemia
#9
Allyson M Morton, Jeremy D Furtado, Jane Lee, William Amerine, Michael H Davidson, Frank M Sacks
BACKGROUND: Lipoprotein subspecies containing apoCIII adversely affect cardiovascular disease (CVD) risk; for example, low density lipoprotein (LDL) with apoCIII is a stronger CVD predictor than LDL without apoCIII. The Epanova for Lowering Very High Triglycerides (EVOLVE) trial showed that Epanova (omega-3 carboxylic acids [OM3-CA]) significantly lowered TG and apoCIII but raised LDL-C. However, it is unknown what subspecies of LDL were affected by treatment. OBJECTIVE: To determine how lipoprotein subspecies are affected by omega-3 fatty acid treatment, we studied the effect of OM3-CA on apoCIII concentrations in high density lipoprotein (HDL), LDL, and very low density lipoprotein (VLDL) and on the concentrations of subspecies of HDL, LDL, and VLDL that contain or do not contain apoCIII...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27875339/apolipoprotein-ciii-is-a-new-player-in-diabetes
#10
Lisa Juntti-Berggren, Per-Olof Berggren
PURPOSE OF REVIEW: Type-1 and type-2 diabetes are diseases with an increasing number of patients and a complex, multifactorial pathogenesis. Apolipoprotein (apo) CIII is increased in both types of diabetes and interventions preventing the increase have effects on the development of diabetes. RECENT FINDINGS: ApoCIII affects intracellular Ca-handling by activating voltage-gated Ca-channels. ApoCIII is produced within the pancreatic islets and it increases in parallel with the development of insulin resistance and type-2 diabetes...
February 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27611192/effects-of-a-plant-sterol-or-stanol-enriched-mixed-meal-on-postprandial-lipid-metabolism-in-healthy-subjects
#11
Sabine Baumgartner, Ronald P Mensink, Jogchum Plat
BACKGROUND: Evidence is increasing that plant sterols and stanols not only lower fasting serum low-density lipoprotein concentrations, but also those of triglycerides (TG). Insight into effects of these components on postprandial TG metabolism, an emerging risk factor for cardiovascular disease, is missing. OBJECTIVE: Our objective was to examine the 8-hour postprandial response after consuming plant sterol or stanol enriched margarine as part of a mixed meal. METHODS: This postprandial study was part of a randomized crossover study in which 42 subjects consumed plant sterol enriched (3 g/d plant sterols), plant stanol enriched (3 g/d plant stanols), and control margarines for 4 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27155393/loganin-inhibits-the-inflammatory-response-in-mouse-3t3l1-adipocytes-and-mouse-model
#12
Yang Li, Zheng Li, Lei Shi, Chenxu Zhao, Bingyu Shen, Ye Tian, Haihua Feng
Atherosclerosis is a chronic inflammatory disease of the vascular walls. ApoCIII is an independent factor which promotes atherosclerotic processes. This study aimed to investigate whether Loganin administration inhibits the inflammatory response in vitro and in vivo. In the apoCIII-induced mouse adipocytes, the levels of cytokines, including TNF-α, MCP-1 and IL-6 were determined by enzyme-linked immunosorbent assay and their gene expressions were measured through RT-PCR. The phosphorylation of nuclear factor-κB (NF-κB) proteins was analyzed by Western blotting...
July 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26970521/severe-hypertriglyceridemia-does-not-protect-from-ischemic-brain-injury-in-gene-modified-hypertriglyceridemic-mice
#13
Yong Chen, Ping Liu, Rong Qi, Yu-Hui Wang, George Liu, Chun Wang
Hypertriglyceridemia (HTG) is a weak risk factor in primary ischemic stroke prevention. However, clinical studies have found a counterintuitive association between a good prognosis after ischemic stroke and HTG. This "HTG paradox" requires confirmation and further explanation. The aim of this study was to experimentally assess this paradox relationship using the gene-modified mice model of extreme HTG. We first used the human Apolipoprotein CIII transgenic (Tg-ApoCIII) mice and non-transgenic (Non-Tg) littermates to examine the effect of HTG on stroke...
May 15, 2016: Brain Research
https://www.readbyqxmd.com/read/26900642/effect-of-leptin-administration-on-circulating-apolipoprotein-ciii-levels-in-patients-with-lipodystrophy
#14
Andrea Kassai, Ranganath Muniyappa, Amy E Levenson, Mary F Walter, Brent S Abel, Michael Ring, Simeon I Taylor, Sudha B Biddinger, Monica C Skarulis, Phillip Gorden, Rebecca J Brown
Patients with lipodystrophy had elevated apolipoprotein CIII (apoCIII) compared to healthy controls. ApoCIII did not change with leptin treatment despite significant reductions in serum triglyceride.
April 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26848137/reduction-in-lipoprotein-associated-apoc-iii-levels-following-volanesorsen-therapy-phase-2-randomized-trial-results
#15
RANDOMIZED CONTROLLED TRIAL
Xiaohong Yang, Sang-Rok Lee, Yun-Seok Choi, Veronica J Alexander, Andres Digenio, Qingqing Yang, Yury I Miller, Joseph L Witztum, Sotirios Tsimikas
Elevated apoC-III levels predict increased cardiovascular risk when present on LDL and HDL particles. We developed novel high-throughput chemiluminescent ELISAs that capture apoB, lipoprotein (a) [Lp(a)], and apoA-I in plasma and then detect apoC-III on these individual lipoproteins as apoCIII-apoB, apoCIII-Lp(a), and apoCIII-apoAI complexes, respectively. We assessed the effects on these complexes of placebo or 100-300 mg volanesorsen, a generation 2.0+ antisense drug that targets apoC3 mRNA in patients with hypertriglyceridemia, including familial chylomicronemia syndrome (n = 3), volanesorsen monotherapy (n = 51), and as add-on to fibrate (n = 26), treated for 85 days and followed for 176 days...
April 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/26773160/multiplexed-peptide-analysis-for-kinetic-measurements-of-major-human-apolipoproteins-by-lc-ms-ms
#16
Mikaël Croyal, Fanta Fall, Véronique Ferchaud-Roucher, Maud Chétiveaux, Yassine Zaïr, Khadija Ouguerram, Michel Krempf, Estelle Nobécourt
A multiplexed assay was developed by MS to analyze, in a single run, six major human Apos involved in lipoprotein metabolism: ApoA-I, ApoA-II, ApoB100, ApoC-II, ApoC-III, and ApoE. This method was validated in vivo in six subjects who received a 14 h constant infusion of [5,5,5-(2)H3]L-leucine at 10 μM/kg/h. Plasma lipoprotein fractions were isolated from collected blood samples and were digested with trypsin. Proteotypic peptides were subsequently analyzed by LC/MS/MS. Enrichment measurement data were compared with those obtained by the standard method using GC/MS...
March 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/26452348/the-association-of-hdl-apociii-with-coronary-heart-disease-and-the-effect-of-statin-treatment-on-it
#17
Xiaowei Xiong, Hong Liu, Lu Hua, Hui Zhao, Dongxue Wang, Yishi Li
BACKGROUND: Apolipoprotein CIII (apoCIII) is considered to impair the anti-atherogenic effect of high density lipoprotein (HDL) in coronary heart disease (CHD) patients, and apoCIII content in HDL (HDL-apoCIII) predicts CHD more accurately. However, the relationship between HDL-apoCIII and CHD, and the effect of statin treatment on HDL-apoCIII are still unclear. The aims of the study are to establish the association of HDL-apoCIII with CHD, and investigate the effect of statin treatment on HDL-apoCIII in CHD patients...
October 9, 2015: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26301570/tryptophan-probes-reveal-residue-specific-phospholipid-interactions-of-apolipoprotein-c-iii
#18
Candace M Pfefferkorn, Robert L Walker, Yi He, James M Gruschus, Jennifer C Lee
Apolipoproteins are essential human proteins for lipid metabolism. Together with phospholipids, they constitute lipoproteins, nm to μm sized particles responsible for transporting cholesterol and triglycerides throughout the body. To investigate specific protein-lipid interactions, we produced and characterized three single-Trp containing apolipoprotein C-III (ApoCIII) variants (W42 (W54F/W65F), W54 (W42F/W65F), W65 (W42F/W54F)). Upon binding to phospholipid vesicles, wild-type ApoCIII adopts an α-helical conformation (50% helicity) as determined by circular dichroism spectroscopy with an approximate apparent partition constant of 3×10(4) M(-1)...
November 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26280786/ledipasvir-sofosbuvir-treatment-of-hepatitis-c-virus-is-associated-with-reduction-in-serum-apolipoprotein-levels
#19
RANDOMIZED CONTROLLED TRIAL
Z M Younossi, E Elsheikh, M Stepanova, L Gerber, F Nader, L M Stamm, D M Brainard, J G McHutchinson
The interaction of lipoproteins with hepatitis C virus (HCV) has pathogenic and therapeutic implications. Our aim was to evaluate changes in the apolipoprotein profile of patients with chronic hepatitis C during and after successful cure with ledipasvir and sofosbuvir (LDV/SOF) with and without ribavirin (RBV). One hundred HCV genotype 1 patients who had achieved SVR-12 after treatment with 12 weeks of LDV/SOF ± RBV were selected from the ION-1 clinical trial. Frozen serum samples from baseline, end of treatment and week 4 of follow-up were used to assay apolipoproteins (apoAI, apoAII, apoB, apoCII, apoCIII, apoE) using the Multiplex platform to assess for changes in the apolipoprotein levels...
December 2015: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/26160324/aggravated-restenosis-and-atherogenesis-in-apociii-transgenic-mice-but-lack-of-protection-in-apociii-knockouts-the-effect-of-authentic-triglyceride-rich-lipoproteins-with-and-without-apociii
#20
Haibo Li, Yingchun Han, Rong Qi, Yuhui Wang, Xiaohong Zhang, Maomao Yu, Yin Tang, Mengyu Wang, Ya-Nan Shu, Wei Huang, Xinfeng Liu, Brian Rodrigues, Mei Han, George Liu
AIM: Previously, our group and others have demonstrated a causative relationship between severe hypertriglyceridaemia and atherogenesis in mice. Furthermore, clinical investigations have shown high levels of plasma Apolipoprotein C-III (ApoCIII) associated with hypertriglyceridaemia and even cardiovascular disease. However, it remains unclear whether ApoCIII affects restenosis in vivo, and whether such an effect is mediated by ApoCIII alone, or in combination with hypertriglyceridaemia...
September 1, 2015: Cardiovascular Research
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