keyword
https://read.qxmd.com/read/37755635/lipoprotein-a-and-benefit-of-pcsk9-inhibition-in-emergency-complex-higher-risk-and-indicated-patients
#21
JOURNAL ARTICLE
Zhi-Li Jin, Tao He, Li Peng, Xiao-Yan Wu, Di Fan, Ming Chen, Yong-Zhen Fan, Yuan-Lin Guo, Zhi-Bing Lu, Hai-Rong Wang
OBJECTIVE: There is a large population of patients classified as complex higher-risk and indicated patients (CHIPs) in China with a poor prognosis. The treatment of these patients is complex and challenging, especially when acute cardiac events occur, such as acute coronary syndrome (ACS) or heart failure. Pharmacotherapy and some mechanical circulatory support (MCS) therapeutic devices can provide stable hemodynamic support for CHIPs-percutaneous coronary intervention (PCI). LDL-C is an important pathogenic factor in atherosclerosis, and the target of blood lipid control...
September 27, 2023: Current Medical Science
https://read.qxmd.com/read/37754581/lipoprotein-a-as-a-risk-factor-for-cardiovascular-diseases-pathophysiology-and-treatment-perspectives
#22
REVIEW
Pierandrea Vinci, Filippo Giorgio Di Girolamo, Emiliano Panizon, Letizia Maria Tosoni, Carla Cerrato, Federica Pellicori, Nicola Altamura, Alessia Pirulli, Michele Zaccari, Chiara Biasinutto, Chiara Roni, Nicola Fiotti, Paolo Schincariol, Alessandro Mangogna, Gianni Biolo
Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all the progress achieved as regards to both prevention and treatment. Having high levels of lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease that operates independently. It can increase the risk of developing cardiovascular disease even when LDL cholesterol (LDL-C) levels are within the recommended range, which is referred to as residual cardiovascular risk. Lp(a) is an LDL-like particle present in human plasma, in which a large plasminogen-like glycoprotein, apolipoprotein(a) [Apo(a)], is covalently bound to Apo B100 via one disulfide bridge...
September 6, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/37650693/lipoprotein-a-and-calcific-aortic-valve-disease-current-evidence-and-future-directions
#23
JOURNAL ARTICLE
Nick S R Lan, Zahid Khan, Gerald F Watts
PURPOSE OF REVIEW: Calcific aortic valve disease (CAVD), the most common cause of aortic stenosis (AS), is characterized by slowly progressive fibrocalcific remodelling of the valve cusps. Once symptomatic, severe AS is associated with poor survival unless surgical or transcatheter valve replacement is performed. Unfortunately, no pharmacological interventions have been demonstrated to alter the natural history of CAVD. Lipoprotein(a) [Lp(a)], a low-density lipoprotein-like particle, has been implicated in the pathophysiology of CAVD...
August 29, 2023: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/37639039/identification-of-the-specific-molecular-and-functional-signatures-of-pre-beta-hdl-relevance-to-cardiovascular-disease
#24
JOURNAL ARTICLE
Isabelle Guillas, Marie Lhomme, Cédric Pionneau, Lucrèce Matheron, Maharajah Ponnaiah, Sophie Galier, Sandrine Lebreton, Marie Delbos, Feng Ma, Maryam Darabi, Petra El Khoury, Marianne Abifadel, Philippe Couvert, Philippe Giral, Philippe Lesnik, Maryse Guerin, Wilfried Le Goff, Anatol Kontush
While low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascular risk factor, HDL-C-rising therapies largely failed, suggesting the importance of both HDL functions and individual subspecies. Indeed HDL particles are highly heterogeneous, with small, dense pre-beta-HDLs being considered highly biologically active but remaining poorly studied, largely reflecting difficulties for their purification. We developed an original experimental approach allowing the isolation of sufficient amounts of human pre-beta-HDLs and revealing the specificity of their proteomic and lipidomic profiles and biological activities...
August 28, 2023: Basic Research in Cardiology
https://read.qxmd.com/read/37580206/hdl-abnormalities-in-type-2-diabetes-clinical-implications
#25
REVIEW
Alexandro J Martagon, Rafael Zubirán, Rogelio González-Arellanes, Samantha Praget-Bracamontes, J Adrián Rivera-Alcántara, Carlos A Aguilar-Salinas
Atherosclerotic cardiovascular disease (ASCVD) represents the primary cause of mortality among patients with Type 2 Diabetes Mellitus (T2DM). In this population, High-Density Lipoprotein (HDL) particles exhibit abnormalities in number, composition, and function, culminating in diminished anti-atherosclerotic capabilities despite normal HDL cholesterol (HDL-C) concentrations. Hyperglycemic conditions contribute to these alterations in HDL kinetics, composition, and function, causing T2DM patients' HDL particles to exhibit decreased concentrations of diverse lipid species and proteins...
August 3, 2023: Atherosclerosis
https://read.qxmd.com/read/37525378/quantitative-assessment-of-lipophilic-membrane-dye-based-labelling-of-extracellular-vesicles-by-nano-flow-cytometry
#26
JOURNAL ARTICLE
Chen Chen, Niangui Cai, Qian Niu, Ye Tian, Yunyun Hu, Xiaomei Yan
Although lipophilic membrane dyes (LMDs) or probes (LMPs) are widely used to label extracellular vesicles (EVs) for detection and purification, their labelling performance has not been systematically characterized. Through concurrent side scattering and fluorescence detection of single EVs as small as 40 nm in diameter by a laboratory-built nano-flow cytometer (nFCM), present study identified that (1) PKH67 and PKH26 could maximally label ∼60%-80% of EVs isolated from the conditioned cell culture medium (purity of ∼88%) and ∼40%-70% of PFP-EVs (purity of ∼73%); (2) excessive PKH26 could cause damage to the EV structure; (3) di-8-ANEPPS and high concentration of DiI could achieve efficient and uniform labelling of EVs with nearly 100% labelling efficiency for di-8-ANEPPS and 70%-100% for DiI; (4) all the four tested LMDs can aggregate and form micelles that exhibit comparable side scatter and fluorescence intensity with those of labelled EVs and thus hardly be differentiate from each other; (5) as the LMD concentration went up, the particle number of self-aggregates increased while the fluorescence intensity of aggregates remained constant; (6) PKH67 and PKH26 tend to form more aggregated micelles than di-8-ANEPPS and DiI, and the effect of LMD self-aggregation can be negligible at optimal staining conditions...
August 2023: Journal of Extracellular Vesicles
https://read.qxmd.com/read/37517914/composition-and-distribution-of-lipoproteins-after-evolocumab-in-familial-dysbetalipoproteinemia-a-randomized-controlled-trial
#27
JOURNAL ARTICLE
Britt E Heidemann, A David Marais, Monique T Mulder, Frank L J Visseren, Jeanine E Roeters van Lennep, Erik S G Stroes, Niels P Riksen, Leonie C van Vark-van der Zee, Dee M Blackhurst, Charlotte Koopal
BACKGROUND: PCSK9 monoclonal antibodies (mAbs) reduce fasting and post fat load cholesterol in non-HDL and IDL in familial dysbetalipoproteinemia (FD). However, the effect of PCSK9 mAbs on the distribution and composition of atherogenic lipoproteins in patients with FD is unknown. OBJECTIVE: To evaluate the effect of the PCSK9 mAb evolocumab added to standard lipid-lowering therapy in patients with FD on fasting and post fat load lipoprotein distribution and composition...
July 22, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/37517561/apolipoprotein-b-compared-with-low-density-lipoprotein-cholesterol-in-the-atherosclerotic-cardiovascular-diseases-risk-assessment
#28
JOURNAL ARTICLE
Federica Galimberti, Manuela Casula, Elena Olmastroni
The subendothelial retention of apolipoprotein B (apoB)-containing lipoproteins is a critical step in the initiation of pro-atherosclerotic processes. Recent genetic and clinical evidence strongly supports the concept that the lipid content of the particles is secondary to the number of circulating atherogenic particles that are trapped within the arterial lumen. Since each low-density lipoproteins (LDL) particle contains one apoB molecule, as do intermediate density lipoprotein (IDL) and very low-density lipoprotein (VLDL) particles, apoB level represents the total number of atherogenic lipoproteins, which is independent of particle density, and not affected by the heterogeneity of particle cholesterol content (clinically evaluated by LDL-cholesterol level)...
July 28, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37453889/improvement-of-lipid-and-lipoprotein-profiles-in-children-and-adolescents-with-cystic-fibrosis-on-cftr-modulator-therapy
#29
JOURNAL ARTICLE
Tatiana Yuzyuk, Catherine M McDonald, Lauren M Zuromski, Irene De Biase, Lisa Johnson, Nicole Williams, Suzanne Meihls, Fadi Asfour
BACKGROUND: Association of a high-fat diet with increased risks of cardiovascular disease (CVD) and type 2 diabetes, has prompted evaluation of lipids in people with CF (pwCF). However, most evidence on dyslipidemia was published before CF transmembrane conductance regulator (CFTR) modulators became a standard of care. The main goal of this study was to investigate the effect of CFTR modulator therapies on lipid and lipoprotein profiles in children and adolescents with CF. METHODS: Blood samples were collected from 153 pwCF (10...
July 13, 2023: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/37452525/lipoprotein-a-a-genetically-determined-risk-factor-for-cardiovascular-disease
#30
REVIEW
Santica M Marcovina
Lipoprotein(a) is a complex lipoprotein with unique characteristics distinguishing it from all the other apolipoprotein B-containing lipoprotein particles. Its lipid composition and the presence of a single molecule of apolipoprotein B per particle, render lipoprotein(a) similar to low-density lipoproteins. However, the presence of a unique, carbohydrate-rich protein termed apolipoprotein(a), linked by a covalent bond to apolipoprotein B imparts unique characteristics to lipoprotein(a) distinguishing it from all the other lipoproteins...
July 14, 2023: Critical Reviews in Clinical Laboratory Sciences
https://read.qxmd.com/read/37425717/tm6sf2-determines-both-the-degree-of-lipidation-and-the-number-of-vldl-particles-secreted-by-the-liver
#31
Gissette Reyes-Soffer, Jing Liu, Tiffany Thomas, Anastasiya Matveyenko, Heather Seid, Rajasekhar Ramakrishnan, Steve Holleran, Norann Zaghloul, Carole Sztalryd-Woodle, Toni Pollin, Henry N Ginsberg
In 2014, exome-wide studies identified a glutamine176lysine (p.E167K) substitution in a protein of unknown function named transmembrane 6 superfamily member 2 (TM6SF2). The p.E167K variant was associated with increased hepatic fat content and reduced levels of plasma TG and LDL cholesterol. Over the next several years, additional studies defined the role of TM6SF2, which resides in the ER and the ER-Golgi interface, in the lipidation of nascent VLDL to generate mature, more TG-rich VLDL. Consistent results from cells and rodents indicated that the secretion of TG was reduced in the p...
June 29, 2023: medRxiv
https://read.qxmd.com/read/37379795/the-counterbalance-of-endothelial-glycocalyx-and-high-wall-shear-stress-to-low-density-lipoprotein-concentration-polarization-in-mouse-ear-skin-arterioles
#32
JOURNAL ARTICLE
Zhilan Deng, Kaixin Sun, Dongyu Sha, Yinuo Zhang, Jiaxin Guo, Guiqin Yan, Weichen Zhang, Ming Liu, Xiaoyan Deng, Hongyan Kang, Anqiang Sun
BACKGROUND AND AIMS: Atherosclerosis preferentially occurs at regions in arterial branching, curvature, and stenosis, which may be explained by the geometric predilection of low-density lipoprotein (LDL) concentration polarization that has been investigated in major arteries in previous studies. Whether this also happens in arterioles remains unknown. METHODS: Herein, a radially non-uniform distribution of LDL particles and a heterogeneous endothelial glycocalyx layer in the mouse ear arterioles, as shown by fluorescein isothiocyanate labeled wheat germ agglutinin (WGA-FITC), were successfully observed by a non-invasive two-photon laser-scanning microscopy (TPLSM) technique...
July 2023: Atherosclerosis
https://read.qxmd.com/read/37333522/cardiometabolic-disease-risk-markers-are-increased-following-burn-injury-in-children
#33
JOURNAL ARTICLE
Sofina Begum, Samantha Lodge, Drew Hall, Blair Z Johnson, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S Fear, Mark W Fear, Elaine Holmes, Fiona M Wood, Jeremy K Nicholson
INTRODUCTION: Burn injury in children causes prolonged systemic effects on physiology and metabolism leading to increased morbidity and mortality, yet much remains undefined regarding the metabolic trajectory towards specific health outcomes. METHODS: A multi-platform strategy was implemented to evaluate the long-term immuno-metabolic consequences of burn injury combining metabolite, lipoprotein, and cytokine panels. Plasma samples from 36 children aged 4-8 years were collected 3 years after a burn injury together with 21 samples from non-injured age and sex matched controls...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37302344/novel-oxidized-ldl-based-clinical-markers-in-peritoneal-dialysis-patients-for-atherosclerosis-risk-assessment
#34
JOURNAL ARTICLE
Polyxeni Papadea, Electra Kalaitzopoulou, Marianna Skipitari, Athina Varemmenou, Marios Papasotiriou, Evangelos Papachristou, Dimitrios Goumenos, Tilman Grune, Christos D Georgiou
Maintenance peritoneal dialysis (PD) is commonly associated with cardiovascular diseases (CVDs), whose risk is assessed via LDL-C. Nonetheless, oxidized LDL (oxLDL), as being a key component of atherosclerotic lesions, could be also associated with atherosclerosis and related CVDs. However, its predictive value for CVDs risk assessment is subject of research studies due to the lack of specific methods to measure oxLDL status from its individual lipid/protein components. In the present study, six novel oxLDL markers, representative of certain oxidative modifications on the LDL protein and lipid components, are measured in atherosclerosis-prone PD patients (39) versus those in chronic kidney disease patients (61) under hemodialysis (HD) and healthy controls (40)...
June 2, 2023: Redox Biology
https://read.qxmd.com/read/37162625/nuclear-magnetic-resonance-determined-lipoprotein-profile-and-risk-of-breast-cancer-a-mendelian-randomization-study
#35
JOURNAL ARTICLE
Jinyu Xiao, Yu Hao, Xueyao Wu, Xunying Zhao, Bin Xu, Chenghan Xiao, Wenqiang Zhang, Li Zhang, Huijie Cui, Chao Yang, Peijing Yan, Mingshuang Tang, Yutong Wang, Lin Chen, Yunjie Liu, Yanqiu Zou, Chunxia Yang, Yuqin Yao, Jiayuan Li, Xia Jiang, Ben Zhang
PURPOSE: While crudely quantified lipoproteins have been reported to affect the risk of breast cancer, the effects of subclass lipoproteins characterized by particle size, particle number, and lipidomes remain unknown. METHODS: Utilizing nuclear magnetic resonance-based GWAS of 85 lipoprotein traits, we performed two-sample univariable Mendelian randomization (MR) to evaluate the causal relationship between each trait with breast cancer (Ncase/control = 133,384/113,789) and with its estrogen receptor (ER) subtypes...
May 10, 2023: Breast Cancer Research and Treatment
https://read.qxmd.com/read/37137225/association-between-nordic-and-mediterranean-diets-with-lipoprotein-phenotype-assessed-by-1-hnmr-in-children-with-familial-hypercholesterolemia
#36
JOURNAL ARTICLE
Cèlia Rodríguez-Borjabad, Ingunn Narveud, Jacob Juel Christensen, Daiana Ibarretxe, Natalia Andreychuk, Josefa Girona, Kristin Torvik, Guro Folkedal, Martin P Bogsrud, Kjetil Retterstøl, Núria Plana, Luis Masana, Kirsten B Holven
BACKGROUND AND AIMS: Both Nordic and Mediterranean diets are considered healthy despite notable regional differences. Although these dietary patterns may lower cardiovascular risk, it is unclear if they improve the lipoprotein phenotype in children with familial hypercholesterolemia (FH). The aim is to determine the impact of Nordic and Mediterranean diets on the advanced lipoprotein profile in children with heterozygous FH (HeFH). METHODS: This was a cross-sectional study performed in children with FH recruited from the Lipid Clinics at Sant Joan University Hospital in Reus (Spain) and Oslo University Hospital (Norway)...
April 22, 2023: Atherosclerosis
https://read.qxmd.com/read/37088651/advanced-lipoprotein-profile-identifies-atherosclerosis-better-than-conventional-lipids-in-type-1-diabetes-at-high-cardiovascular-risk
#37
JOURNAL ARTICLE
Tonet Serés-Noriega, Emilio Ortega, Marga Giménez, Verónica Perea, Laura Boswell, Karla Mariaca, Carla Font, Alex Mesa, Clara Viñals, Jesús Blanco, Irene Vinagre, Adriana Pané, Enric Esmatjes, Ignacio Conget, Antonio J Amor
BACKGROUND AND AIMS: People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D. METHODS AND RESULTS: Cross-sectional study in subjects with T1D, without previous CVD, but high-risk (≥40 years, nephropathy, or ≥10 years of evolution of diabetes with another risk factor)...
April 5, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/37051929/contribution-of-apoe-genetic-variants-to-dyslipidemia
#38
JOURNAL ARTICLE
Ana M Bea, Asier Larrea-Sebal, Victoria Marco-Benedi, Kepa B Uribe, Unai Galicia-Garcia, Itziar Lamiquiz-Moneo, Martín Laclaustra, Belén Moreno-Franco, Pablo Fernandez-Corredoira, Salvador Olmos, Fernando Civeira, César Martin, Ana Cenarro
BACKGROUND: apo (apolipoprotein) E has crucial role in lipid metabolism. The genetic variation in APOE gene is associated with monogenic disorders and contributes to polygenic hypercholesterolemia and to interindividual variability in cholesterol. APOE rare variants may be involved in the phenotype of genetic hyperlipidemias. METHODS: Exon 4 of APOE were sequenced in all consecutive unrelated subjects with primary hyperlipidemia from a Lipid Unit (n=3667) and 822 random subjects from the Aragon Workers Health Study...
June 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/37049588/effects-of-free-linoleic-acid-and-oleic-acid-in-sesame-meal-extract-as-pancreatic-lipase-inhibitors-on-postprandial-triglyceridemia-a-randomized-double-blind-placebo-controlled-crossover-study-in-healthy-volunteers
#39
RANDOMIZED CONTROLLED TRIAL
Xuan Li, Hiroaki Yamada, Sayo Morita, Yusuke Yamashita, Youngil Kim, Takashi Kometani, Nikesh Narang, Toma Furuta, Mujo Kim
A great number of chemically diverse pancreatic lipase (PL) inhibitors have been identified to tackle obesity; however, very few of them have entered clinical studies. The ethanolic extract of sesame meal is a potent PL inhibitor, and its activity hinges exclusively on two free fatty acids: linoleic acid and oleic acid, which were proven to reduce postprandial triglyceride excursion in rats. Herein, to investigate the clinical efficacy of the sesame meal extract, in a crossover trial, 30 healthy volunteers were randomized to receive the sesame meal extract containing experimental food or placebo along with a high-fat meal...
April 3, 2023: Nutrients
https://read.qxmd.com/read/36982465/hdl-function-and-size-in-patients-with-on-target-ldl-plasma-levels-and-a-first-onset-acs
#40
JOURNAL ARTICLE
Alberto Cordero, Natàlia Muñoz-García, Teresa Padró, Gemma Vilahur, Vicente Bertomeu-González, David Escribano, Emilio Flores, Pilar Zuazola, Lina Badimon
Patients admitted for acute coronary syndrome (ACS) usually have high cardiovascular risk scores with low levels of high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels. Here, we investigated the role of lipoprotein functionality as well as particle number and size in patients with a first-onset ACS with on-target LDL-C levels. Ninety-seven patients with chest pain and first-onset ACS with LDL-C levels of 100 ± 4 mg/dL and non-HDL-C levels of 128 ± 4...
March 11, 2023: International Journal of Molecular Sciences
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