Jinyu Xiao, Yu Hao, Xueyao Wu, Xunying Zhao, Bin Xu, Chenghan Xiao, Wenqiang Zhang, Li Zhang, Huijie Cui, Chao Yang, Peijing Yan, Mingshuang Tang, Yutong Wang, Lin Chen, Yunjie Liu, Yanqiu Zou, Chunxia Yang, Yuqin Yao, Jiayuan Li, Xia Jiang, Ben Zhang
PURPOSE: While crudely quantified lipoproteins have been reported to affect the risk of breast cancer, the effects of subclass lipoproteins characterized by particle size, particle number, and lipidomes remain unknown. METHODS: Utilizing nuclear magnetic resonance-based GWAS of 85 lipoprotein traits, we performed two-sample univariable Mendelian randomization (MR) to evaluate the causal relationship between each trait with breast cancer (Ncase/control = 133,384/113,789) and with its estrogen receptor (ER) subtypes...
May 10, 2023: Breast Cancer Research and Treatment