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https://www.readbyqxmd.com/read/28805698/artemisia-iwayomogi-extract-attenuates-high-fat-diet-induced-hypertriglyceridemia-in-mice-potential-involvement-of-the-adiponectin-ampk-pathway-and-very-low-density-lipoprotein-assembly-in-the-liver
#1
Jinhui Lee, Vikram P Narayan, Eun Young Hong, Wan Kyunn Whang, Taesun Park
This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804986/effects-of-hydroxycitric-acid-on-lipid-droplet-accumulation-in-chicken-embryos
#2
Mengling Peng, Longlong Li, Lei Yu, Chongyang Ge, Haitian Ma
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P < 0...
August 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28804736/urokinase-type-plasminogen-activator-upa-and-its-receptor-upar-promote-neurorepair-in-the-ischemic-brain
#3
Paola Merino, Ariel Diaz, Manuel Yepes
Despite the fact that ischemic stroke has been considered a leading cause of mortality in the world, recent advances in our understanding of the pathophysiological mechanisms underlying the ischemic injury and the treatment of acute ischemic stroke patients have led to a sharp decrease in the number of stroke deaths. However, this decrease in stroke mortality has also led to an increase in the number of patients that survive the acute ischemic injury with different degrees of disability. Unfortunately, to this date we do not have an effective therapeutic strategy to promote neurological recovery in these growing population of stroke survivors...
2017: Receptors & Clinical Investigation
https://www.readbyqxmd.com/read/28804559/microrna-1907-enhances-atherosclerosis-associated-endothelial-cell-apoptosis-by-suppressing-bcl-2
#4
Jin Zhao, Shu-Lin Ou, Wei-You Wang, Chang Yan, Lu-Xiang Chi
Injury and endothelial cell apoptosis are hall marks of atherosclerosis (AS). However, the mechanisms underlying its pathogenesis remain ill-defined. Recent evidence of a role for microRNAs in AS-associated endothelial cell apoptosis encouraged us to address this question. Here, AS was developed in ApoE (-/-) mice supplied with a high-fat diet (HFD), compared to ApoE (-/-) mice supplied with a normal diet (ND). Mouse endothelial cells were isolated from the aortic arch using flow cytometry based on their expression of CD31...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28804440/effect-of-dietary-interventions-during-weaning-period-on-parental-practice-and-lipoproteins-and-vitamin-d-status-in-two-year-old-children
#5
Nina Cecilie Øverby, Sigrunn Hernes, Margaretha Haugen
Objective: Evaluate if a two-day course for parents on nutrition and applied baby food preparation had an effect on child's intake of home-made foods, lipid concentration, and vitamin D status. Design: Randomized controlled trial at age 6 months and follow-up at ages 15 and 24 months. Setting: Four health care clinics in Kristiansand, Norway. Subjects: Thirty-nine pairs of 6-month-old children and their parents in the intervention group and 20 pairs in the control group. Results: At age 15 months, the intervention group had lower intakes of ready-made porridge (2...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28804438/green-tea-extract-induces-genes-related-to-browning-of-white-adipose-tissue-and-limits-weight-gain-in-high-energy-diet-fed-rat
#6
Li-Han Chen, Yi-Wen Chien, Chung-Tiang Liang, Ching-Hung Chan, Meng-Han Fan, Hui-Yu Huang
Background: A wealth of research has reported on the anti-obesity effects of green tea extract (GTE). Although browning of white adipose tissue (WAT) has been reported to attenuate obesity, no study has disclosed the effects of GTE on browning in Sprague Dawley rats. Objectives: The aims of the study were to investigate the effects of GTE on anti-obesity and browning, and their underlying mechanisms. Methods: Four groups of rats (n=10/group) were used including a normal diet with vehicle treatment, and a high-energy diet (HED) with vehicle or GTE by oral gavage at 77...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28803825/cardiovascular-events-after-exposure-to-nilotinib-in-chronic-myeloid-leukemia-long-term-follow-up
#7
Nazanin Aghel, Jeffrey Howard Lipton, Eshetu G Atenafu, Dennis Dong Hwan Kim, Diego Hernan Delgado
INTRODUCTION: Nilotinib is a highly effective tyrosine kinase inhibitor in the treatment of chronic myeloid leukemia (CML). However, reports of cardiovascular toxicities caused by nilotinib have recently raised critical concerns. The aim of the present study was to evaluate the incidence of cardiovascular events (CVEs) and frequency of asymptomatic peripheral arterial disease (PAD) after long-term exposure to nilotinib. PATIENTS AND METHODS: In the present retrospective cohort, we evaluated the incidence of CVEs in 63 CML patients treated with nilotinib...
July 15, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28802640/nonalcoholic-fatty-liver-disease-associated-with-metabolic-syndrome-influence-of-liver-fibrosis-stages-on-characteristics-of-very-low-density-lipoproteins
#8
Diego Lucero, Verónica Miksztowicz, Gisela Gualano, Cristina Longo, Graciela Landeira, Estela Álvarez, Valeria Zago, Fernando Brites, Gabriela Berg, Eduardo Fassio, Laura Schreier
BACKGROUND: We evaluated possible changes in VLDLcharacteristics, and metabolic related factors, in MetS-associated NAFLD and accompanying liver fibrosis. METHODS: We studied 36 MetS patients with biopsy-proven NAFLD (MetS+NAFLD) and 24 MetS without ultrasound NAFLD evidence. Further, MetS+NAFLD was sub-divided according to fibrosis stage into, non-to-moderate (F0-F2, n=27) and severe (F3-F4, n=9) fibrosis. We measured: lipid profile, VLDL composition and size (size exclusion-HPLC), CETP and lipoprotein lipase (LPL) activities and adiponectin...
August 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28802576/atorvastatin-and-lovastatin-but-not-pravastatin-increased-cellular-complex-formation-between-pcsk9-and-the-ldl-receptor-in-human-hepatocyte-like-c3a-cells
#9
Quantil M Melendez, Catherine J Wooten, Dayami Lopez
Statins are the first-line treatment for hypercholesterolemic patients. Herein, the effects of three statins on complex formation between proprotein convertase subtilisin-kexin 9 (PCSK9) and the low density lipoprotein receptor (LDLR), a critical step for the PCSK9-dependent degradation of LDLR in the lysosome, were examined. Human hepatocyte-like C3A cells grown in control (containing 10% fetal bovine serum) or MITO+ (supplemented with BD™ MITO + serum extender) medium were also treated with atorvastatin (Atorv), lovastatin (Lov), or pravastatin (Prav) for 24 h...
August 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28802304/coffee-consumption-and-coronary-heart-disease-risk-using-the-framingham-risk-score
#10
Hye-Mi Noh, Yong Soon Park, Jeong-Hyeon Kim
BACKGROUND AND OBJECTIVES: Although concerns regarding the influence of coffee consumption on human health have accompanied the massive increase in coffee consumption, the effects of coffee intake on the risk for coronary heart disease (CHD) remain controversial. Therefore, we evaluated the association between coffee consumption and CHD risk as estimated using the Framingham risk model in Korean adults. METHODS AND STUDY DESIGN: This cross-sectional study involved 3,987 participants aged 30-74 years who participated in the fifth Korea National Health and Nutrition Examination Survey conducted in 2010...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28801822/simultaneous-quantification-of-free-cholesterol-cholesteryl-esters-and-triglycerides-without-ester-hydrolysis-by-uhplc-separation-and-in-source-collision-induced-dissociation-coupled-ms-ms
#11
Michael S Gardner, Lisa G McWilliams, Jeffrey I Jones, Zsuzsanna Kuklenyik, James L Pirkle, John R Barr
We demonstrate the application of in-source nitrogen collision-induced dissociation (CID) that eliminates the need for ester hydrolysis before simultaneous analysis of esterified cholesterol (EC) and triglycerides (TG) along with free cholesterol (FC) from human serum, using normal phase liquid chromatography (LC) coupled to atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (MS/MS). The analysis requires only 50 μL of 1:100 dilute serum with a high-throughput, precipitation/evaporation/extraction protocol in one pot...
August 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28801773/growth-performance-mineral-digestibility-and-blood-characteristics-of-ostriches-receiving-drinking-water-supplemented-with-varying-levels-of-chelated-trace-mineral-complex
#12
Hossein Seyfori, Hossein Ali Ghasemi, Iman Hajkhodadadi, Mohammad Hassan Nazaran, Maryam Hafizi
The effects of water supplementation of chelated trace minerals (CTM, which is named Bonzaplex designed with chelate compounds technology) on growth performance, apparent total tract digestibility (ATTD) of minerals, and some blood metabolites, TM, and antioxidant enzyme values in African ostriches were investigated from 8 to 12 months of age. A total of 20 8-month-old ostriches (five birds in five replicate pens) was randomly allocated into one of the following four treatments: (1) control (basal diet + tap water), (2) low CTM (basal diet +100 mg/bird/day CTM powder in tap water), (3) medium CTM (basal diet +1 g/bird/day CTM powder in tap water), and (4) high CTM (basal diet +2 g/bird/day CTM powder in tap water)...
August 11, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28801649/protein-o-mannosylation-deficiency-increases-lprg-associated-lipoarabinomannan-release-by-mycobacterium-tuberculosis-and-enhances-the-tlr2-associated-inflammatory-response
#13
Henar Alonso, Julien Parra, Wladimir Malaga, Delphine Payros, Chia-Fang Liu, Céline Berrone, Camille Robert, Etienne Meunier, Odile Burlet-Schiltz, Michel Rivière, Christophe Guilhot
Protein O-mannosylation is crucial for the biology of Mycobacterium tuberculosis but the key mannosylated protein(s) involved and its(their) underlying function(s) remain unknown. Here, we demonstrated that the M. tuberculosis mutant (Δpmt) deficient for protein O-mannosylation exhibits enhanced release of lipoarabinomannan (LAM) in a complex with LprG, a lipoprotein required for LAM translocation to the cell surface. We determined that LprG is O-mannosylated at a unique threonine position by mass spectrometry analyses of the purified protein...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801309/determining-the-mechanisms-of-dietary-turnip-rapeseed-oil-on-cholesterol-metabolism-in-men-with-metabolic-syndrome
#14
Harri Juhani Saarinen, Chaiyasit Sittiwet, Piia Simonen, Markku J Nissinen, Ulf-Håkan Stenman, Helena Gylling, Ari Palomäki
We have earlier reported the reduction of total cholesterol, low-density lipoprotein (LDL) cholesterol and oxidized LDL caused by short-term modification of diet with cold-pressed turnip rapeseed oil (CPTRO) instead of butter. The aim of this supplementary study was to determine whether the beneficial effects resulted from altered cholesterol metabolism during the intervention.Thirty-seven men with metabolic syndrome (MetS) completed an open, randomized and balanced crossover study. Subjects' usual diet was supplemented with either 37...
August 11, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28801292/-oxidized-low-density-lipoprotein-modulates-differentiation-of-murine-memory-cd8-t-cell-subpopulations
#15
Hua Zheng, Ze-Hang Lin, Yan-Mei Zhang, Chen-Fei Zhou, Xuan Liu, Sha Wu
OBJECTIVE: To investigate effect of oxidized low-density lipoprotein (ox-LDL) on memory CD8(+) T cell subpopulation differentiation in mice with autoimmune diabetes. METHODS: Cultured splenic CD8(+) T cells from pre-diabetic NOD mice isolated with magnetic beads were treated with 30 µg/mL ox-LDL and 10 U/mL interleukin-2 (IL-2) for 24 h and the control cells were treated with IL-2 only. Flow cytometry was used to determine the percentage of splenic CD8(+)IFN-γ(+) T cells, expressions of CD8, CD44 and CD62L on the T cells, and the activation of T cell factor-1 (TCF-1) and STAT-3...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28801277/-pioglitazone-ameliorates-atherosclerosis-in-apoe-knockout-mice-through-transforming-growth-factor-%C3%AE-smad-signaling-and-adaptive-t-cell-immunity
#16
Yu-Ling Tian, Li-Jun Wang, Yue Wu, Wei-Ping Zhang, Xiao Liang, Zu-Yi Yuan
OBJECTIVE: To examine whether transforming growth factor-β (TGF-β) pathway and adaptive T cell immunity play roles in the anti-atherosclerotic effects of pioglitazone (PIO) in ApoE(-/-) mice. METHODS: ApoE(-/-) mice with atherosclerosis induced by high-fat feeding were treated daily with PIO (20 mg/kg) or vehicle for 8 weeks. The protein expressions of TGF-β pathway in the atheromatous lesions of the aorta and the percentages of IFN-γ(+) and Foxp3(+) cells in the spleen of the mice were examined with immunohistochemical staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28801090/leptin-concentrations-and-scd-1-indices-in-classical-homocystinuria-evidence-for-the-role-of-sulfur-amino-acids-in-the-regulation-of-lipid-metabolism
#17
Soraia Poloni, Poli Mara Spritzer, Roberta H Mendes, Vânia D'almeida, Kamila Castro, Fernanda Sperb-Ludwig, Johanna Kugele, Sara Tucci, Henk J Blom, Ida V D Schwartz
BACKGROUND: We describe body composition, lipid metabolism and Stearoyl-CoA desaturase-1 (SCD-1) indices in patients with classical homocystinuria (HCU). METHODS: Eleven treated HCU patients and 16 healthy controls were included. Body composition and bone mineral density were assessed by dual X-ray absorptiometry. Sulfur-containing amino acids (SAA) and their derivatives (total homocysteine, cysteine, methionine, S-adenosylmethionine, S-adenosylhomocysteine, and glutathione), lipids (free fatty acids, acylcarnitines, triglycerides and lipoproteins), glucose, insulin, leptin, adiponectin, and isoprostanes were measured in plasma...
August 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28801030/lipoprotein-a-screening-in-patients-with-controlled-traditional-risk-factors-undergoing-percutaneous-coronary-intervention
#18
Matthew C Weiss, Jeffrey S Berger, Eugenia Gianos, Edward Fisher, Arthur Schwartzbard, James Underberg, Howard Weintraub
BACKGROUND: Lipoprotein(a) [Lp(a)] is an inherited atherogenic lipoprotein and an independent risk factor for atherosclerotic cardiovascular disease; however, its clinical role remains limited. OBJECTIVE: We hypothesized that Lp(a) screening in high cardiovascular risk patients could provide insight into disease pathogenesis and modify physician behavior for treatment intensification targeting traditional risk factors when Lp(a)-related risk was identified. METHODS: We screened 113 patients presenting electively for percutaneous coronary intervention (PCI) for Lp(a) who met any of the following criteria: (1) premature coronary artery disease (male age <55 years, female age <65 years); (2) family history of premature coronary artery disease; (3) progression to PCI despite well-controlled traditional risk factors (blood pressure <140/90 mm Hg, and low-density lipoprotein cholesterol <100 mg/dL, and HbA1c <7%, and nonsmoker); or (4) progression to PCI despite at least moderate intensity statin use (simvastatin 40, atorvastatin 40-80, or rosuvastatin 20-40 mg daily)...
July 22, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28801029/cardiovascular-disease-in-familial-hypercholesterolemia-validation-and-refinement-of-the-montreal-fh-score
#19
Martine Paquette, Diane Brisson, Robert Dufour, Étienne Khoury, Daniel Gaudet, Alexis Baass
BACKGROUND: Familial hypercholesterolemia (FH) is a disease characterized by increased low-density lipoprotein cholesterol and premature cardiovascular disease (CVD) but there is marked individuality in the occurrence of CVD events. Recently, the Montreal-FH-SCORE (MFHS) has been shown to stratify CVD frequency in FH subjects, but this score has not yet been validated. OBJECTIVE: The aims of the present study were to conduct an independent external validation of the MFHS in a retrospective cohort of heterozygous FH and to identify additional variables that could significantly improve the prediction of prevalent CVD...
July 27, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28800440/low-density-lipoprotein-transport-through-patient-specific-thoracic-arterial-wall
#20
Dimitrios G Mpairaktaris, Johannes V Soulis, George D Giannoglou
BACKGROUND AND AIMS: The distribution of Low density lipoprotein (LDL) within the arterial wall is helpful in understanding the onset and development of atherosclerosis. The objective of the study is to study the transport and LDL distribution within patient-specific arterial wall using computational analysis under normal and hypertensive conditions. METHODS: Patient specific model of the thoracic aorta is computationally examined. The arterial wall is treated macroscopically as homogeneous (one layered) porous media of variable thickness...
August 3, 2017: Computers in Biology and Medicine
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