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https://www.readbyqxmd.com/read/28545371/if-rodents-could-speak-a-psycho-behavioral-perspective-on-modelling-obsessive-compulsive-disorder-ocd-in-animals-the-role-of-context
#1
De Wet Wolmarans, Dan J Stein, Brian H Harvey
Obsessive-compulsive disorder is a heterogeneous and debilitating condition, characterized by intrusive thoughts and compulsive repetition over several domains of human functioning. Animal models of OCD are important instruments that have the potential to contribute significantly to our understanding of the condition. However, although there is consensus that pre-clinical models are valuable to elucidate the underlying neurobiology in psychiatric disease, the current paper attempts to prompt ideas on how interpretation of animal behavior can be expanded upon to more effectively converge with the human disorder...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28529655/scfe-clinical-aspects-diagnosis-and-classification
#2
M B Millis
PURPOSE: This article seeks to improve treatment outcomes in slipped capital femoral epiphysis (SCFE) by outlining advances in diagnosis, understanding of pathomechanics, and mechanically-based classification. METHODS: Review of clinical experience with SCFE at our high-volume centre, interaction with other clinical experts, and literature review has allowed a current perspective to be articulated. RESULTS: SCFE remains an important clinical problem, with late diagnosis still frequent...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28511123/dismissing-the-goals-a-comparison-of-four-goal-dismissive-goal-free-evaluations
#3
Brandon W Youker, Ken Ford, Nicholas Bayer
This article provides a descriptive review of four goal-free evaluations (GFE). GFE is an evaluation model where the evaluator conducts the evaluation without knowledge of or reference to the evaluand's stated goals. The four non-randomly sampled evaluation approaches represent articulated evaluation models in which the evaluators ignore the goals of the intervention or project. Data collection consisted of document analyses supplemented by semi-structured interviews with the models' creators. The findings from these case studies include descriptions of the evaluation models, the models' relationship to GFE, and eight commonalities shared among the four models...
May 9, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28493934/taking-stock-of-the-social-determinants-of-health-a-scoping-review
#4
Kelsey Lucyk, Lindsay McLaren
BACKGROUND: In recent decades, the social determinants of health (SDOH) has gained increasing prominence as a foundational concept for population and public health in academic literature and policy documents, internationally. However, alongside its widespread dissemination, and in light of multiple conceptual models, lists, and frameworks, some dilution and confusion is apparent. This scoping review represents an attempt to take stock of SDOH literature in the context of contemporary population and public health...
2017: PloS One
https://www.readbyqxmd.com/read/28483239/the-efficacy-and-safety-of-the-flexible-fiber-co2-laser-delivery-system-in-the-endoscopic-management-of-pediatric-airway-problems-our-long-term-experience
#5
Gi Soo Lee, Alexandra Irace, Reza Rahbar
OBJECTIVE: To report the use of flexible fiber CO2 laser in the endoscopic management of pediatric airway cases. METHODS: A retrospective review was conducted of patients who underwent CO2 laser-assisted airway procedures between September 2007 and January 2014 at a tertiary pediatric hospital. RESULTS: Sixty-eight patients underwent 80 procedures utilizing flexible fiber CO2 laser. Procedures included supraglottoplasty (n = 32), laryngeal cleft repair (type I [n = 10], type II [n = 7], type III [n = 6]), suprastomal granuloma excision (n = 6), cordotomy (n = 4), laryngeal neurofibroma excision (n = 4), laryngeal granulomatous mass excision (n = 1), subglottic stenosis excision (n = 6), division of glottic web (n = 2), subglottic cyst excision (n = 1), and supraglottic biopsy (n = 1)...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28462215/condylar-constrained-system-in-primary-total-knee-replacement-our-experience-and-literature-review
#6
Luigi Sabatini, Salvatore Risitano, Lorenzo Rissolio, Andrea Bonani, Francesco Atzori, Alessandro Massè
BACKGROUND: Constrained condylar knee (CCK) prosthesis are common used for revision surgery but can also help surgeons to improve implant stability in primary knee arthroplasty, in fact in severe knee arthrosis with serious deformity associated with a significant instability a more constrained articulation is required. With introduction of second generation of semi-constrained prosthesis, rate of complication is real decreased and a good survival rate and functional score results is showed...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28452673/improving-mental-health-in-the-community-outcome-evaluation-of-a-geriatric-mental-health-day-treatment-service
#7
Christine A Knight, Richard M Alarie
OBJECTIVES: This program evaluation reviewed the outcomes of a new 10-week multi-modal mental health day treatment program for elderly clients with mood and anxiety disorders. METHODS: A retrospective chart review of clients admitted during the first 3 years of the program (N = 255) was conducted. Paired sample t-tests were used to compare admission and discharge data. Focus groups were run with clients who attended the program during the previous months, to delineate the strengths of the program and to identify areas for improvement...
March 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28450205/nucleic-acid-combinations-a-new-frontier-for-cancer-treatment
#8
REVIEW
Remant Bahadur K C, Bindu Thapa, Juliana Valencia-Serna, Hamidreza Montezari Aliabadi, Hasan Uludağ
The emerging molecular understanding of cancer cell behavior is leading to increasing possibilities to control unchecked cell growth and metastasis. On the other hand, development of multifunctional drug carriers at the 'nano'-scale is providing exciting new therapeutic strategies in clinical management of cancer beyond the conventional cytotoxic drugs. A new frontier in this regard is the combinational use of complementary agents based on nucleic acids to overcome the limitations of conventional therapy. The existence of tightly-integrated cross-talk through multiple signaling and effector pathways have been appreciated for some time, and the plasticity of such a network to overcome one-dimensional intervention is stimulating development of combinational therapy...
April 24, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28449598/using-grade-as-a-framework-to-guide-research-on-the-sexual-and-reproductive-health-and-rights-srhr-of-women-living-with-hiv-methodological-opportunities-and-challenges
#9
Nandi Siegfried, Manjulaa Narasimhan, Caitlin E Kennedy, Alice Welbourn, Anandi Yuvraj
In March 2016, WHO reviewed evidence to develop global recommendations on the sexual and reproductive health and rights (SRHR) of women living with HIV. Systematic reviews and a global survey of women living with HIV informed the guideline development decision-making process. New recommendations covered abortion, Caesarean section, safe disclosure, and empowerment and self-efficacy interventions. Identification of key research gaps is part of the WHO guidelines development process, but consistent methods to do so are lacking...
April 27, 2017: AIDS Care
https://www.readbyqxmd.com/read/28429302/ethics-guidelines-in-environmental-epidemiology-their-development-and-challenges-we-face
#10
REVIEW
Shira Kramer, Colin L Soskolne
PURPOSE OF REVIEW: This review integrates historical developments and key events in bringing ethics into epidemiology in general and into environmental epidemiology in particular. The goal is to provide context for and discern among the various approaches and motivations that drive the need for ethical conduct in support of the public interest. RECENT FINDINGS: The need for ethics guidelines in epidemiology is different from developments in other biomedical-related fields by virtue of its focus on populations rather than on individuals...
April 20, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28419034/complications-and-functional-outcomes-after-pantalar-dislocation
#11
Kaeleen A Boden, Douglas S Weinberg, Heather A Vallier
BACKGROUND: Pantalar dislocations without associated talar fracture are rare and have high risks of complications, including infection, osteonecrosis, and posttraumatic osteoarthrosis. Limited information on later function exists. This study evaluated complications and outcomes following pantalar dislocation without talar fracture. METHODS: Nineteen patients were identified with open (n = 14) or closed (n = 5) pantalar dislocations without talar fracture. Ten male and 9 female patients with a mean age of 39...
April 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28392082/neglect-as-a-violation-of-species-expectant-experience-neurodevelopmental-consequences
#12
REVIEW
Katie A McLaughlin, Margaret A Sheridan, Charles A Nelson
The human brain requires a wide variety of experiences and environmental inputs in order to develop normally. Children who are neglected by caregivers or raised in institutional environments are deprived of numerous types of species-expectant environmental experiences. In this review, we articulate a model of how the absence of cognitive stimulation and sensory, motor, linguistic, and social experiences common among children raised in deprived early environments constrains early forms of learning, producing long-term deficits in complex cognitive function and associative learning...
February 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28385199/neuromyelitis-spectrum-disorders
#13
REVIEW
Brian G Weinshenker, Dean M Wingerchuk
The understanding of neuromyelitis optica spectrum disorder (NMOSD) has evolved substantially since its initial description over a century ago. The discovery in 2004 of a pathogenic autoantibody biomarker targeting aquaporin 4 IgG revolutionized diagnosis and therapeutic development. Although NMOSD resembles multiple sclerosis (MS), differences were identified and articulated in the late 1990s. New diagnostic criteria incorporating the biomarker as well as better understanding of the clinical and radiologic features of NMOSD now permit accurate diagnosis and differentiation from MS...
April 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28376785/patients-support-for-health-information-exchange-a-literature-review-and-classification-of-key-factors
#14
Pouyan Esmaeilzadeh, Murali Sambasivan
BACKGROUND: Literature indicates that one of the most important factors affecting the widespread adoption of Health Information Exchange (HIE) is patient support and endorsement. In order to reap all the expected benefits of HIE, patients' acceptance of technology is a challenge that is not fully studied. There are a few studies which have focused on requirements of electronic medical information exchange from consumers' views and expectations. This study is aimed at reviewing the literature to articulate factors that affect patients to support HIE efforts...
April 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28374350/teaching-the-basics-development-and-validation-of-a-distal-radius-reduction-and-casting-model
#15
Mark A Seeley, Peter D Fabricant, J Todd R Lawrence
BACKGROUND: Approximately one-third of reduced pediatric distal radius fractures redisplace, resulting in further treatment. Two major modifiable risk factors for loss of reduction are reduction adequacy and cast quality. Closed reduction and immobilization of distal radius fractures is an Accreditation Council for Graduate Medical Education residency milestone. Teaching and assessing competency could be improved with a life-like simulation training tool. QUESTIONS/PURPOSES: Our goal was to develop and validate a realistic distal radius fracture reduction and casting simulator as determined by (1) a questionnaire regarding the "realism" of the model and (2) the quantitative assessments of reduction time, residual angulation, and displacement...
April 3, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28326913/reflecting-on-the-learning-opportunities-of-presenting-at-a-conference
#16
Beverly Joshua
Background Research productivity is a major indicator of higher educational institutions' (HEI) academic performance. The increasing focus on research productivity is resulting in an expectation that academics publish their research initiatives, ideas and developments in their scope of work or area of interest. It can influence academic status and compel nursing academics to undertake higher degrees, including PhDs or other doctoral studies. Aim To articulate a nurse academic's reflection on presenting her doctoral thesis at an international conference and to encourage students to embrace the dissemination of research...
March 22, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/28320168/a-systematic-comparison-of-key-features-of-ischemic-stroke-prevention-guidelines-in-low-and-middle-income-vs-high-income-countries
#17
REVIEW
Hernán Bayona, Mayowa Owolabi, Wuwei Feng, Paul Olowoyo, Joseph Yaria, Rufus Akinyemi, James R Sawers, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Implementation of contextually appropriate, evidence-based, expert-recommended stroke prevention guideline is particularly important in Low-Income Countries (LMICs), which bear disproportional larger burden of stroke while possessing fewer resources. However, key quality characteristics of guidelines issued in LMICs compared with those in High-Income Countries (HICs) have not been systematically studied. We aimed to compare important features of stroke prevention guidelines issued in these groups...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318768/clinical-development-strategy-for-a-candidate-group-a-streptococcal-vaccine
#18
REVIEW
Florian Schödel, Nicole J Moreland, Janet T Wittes, Kim Mulholland, Ian Frazer, Andrew C Steer, John D Fraser, Jonathan Carapetis
GroupA streptococci (GAS) cause a wide spectrum of diseases ranging from benign pharyngitis and skin infections to severe invasive disease and the immune sequelae rheumatic fever and rheumatic heart disease. Pharyngitis, one of the most frequent diseases caused by GAS, is highly prevalent in school-age children in temperate climates and a major cause of antibiotic use. An efficacious vaccine would reduce disease burden associated with pharyngitis and the need of care for sick children. Importantly, GAS pharyngitis is recognised as the main precursor for acute rheumatic fever so a vaccine that is efficacious against GAS pharyngitis should also prevent acute rheumatic fever and rheumatic heart disease...
March 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28301774/geometric-principles-for-designing-highly-symmetric-self-assembling-protein-nanomaterials
#19
Todd O Yeates
Emerging protein design strategies are enabling the creation of diverse, self-assembling supramolecular structures with precision on the atomic scale. The design possibilities include various types of architectures: finite cages or shells, essentially unbounded two-dimensional and three-dimensional arrays (i.e., crystals), and linear or tubular filaments. In nature, structures of those types are generally symmetric, and, accordingly, symmetry provides a powerful guide for developing new design approaches. Recent design studies have produced numerous protein assemblies in close agreement with geometric specifications...
February 23, 2017: Annual Review of Biophysics
https://www.readbyqxmd.com/read/28292404/gastric-plication
#20
REVIEW
Nitin Kumar
Endoscopic gastric plication techniques are effective for weight loss. These procedures offer the potential for higher efficacy than conservative modalities, such as medications and lifestyle modifications, and lower invasiveness than bariatric surgery. Gastric plication techniques include endoscopic sleeve gastroplasty, primary obesity surgery endolumenal, transoral gastroplasty, and plication with the Articulating Endoscopic Circular (ACE) stapler. Currently, primary obesity surgery endolumenal is under review by the US Food and Drug Administration, and endoscopic sleeve gastroplasty is gaining acceptance...
April 2017: Gastrointestinal Endoscopy Clinics of North America
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