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https://www.readbyqxmd.com/read/29775647/exposure-to-imipenem-cilastatin-causes-nephrotoxicity-and-even-urolithiasis-in-wistar-rats
#1
Amal Tahri, Amina Lahyani, Rim Kallel, Fatma Ayadi, Tahia Boudawara, Zouheir Sahnoun
Imipenem/cilastatin is a broad-spectrum β-lactam antibiotic used to treat several bacterial infections. The present study was designed to validate the nephrotoxic effect of this drug in rats and to explore its potentional urolithiatic effect. Thirty two Wistar rats were randomly divided into four groups: three experimental groups treated with different imipenem/cilastatin dosages (30, 50 and 80 mg/kg/day) and a control group.The experimental groups were given intraperitoneal imipenem/cilastatin injections twice daily for 7 days, and the control group was given intraperitoneal vehicle NaCl 0...
May 17, 2018: Toxicology
https://www.readbyqxmd.com/read/29775211/proanthocyanidins-will-they-effectively-restrain-conspicuous-bacterial-strains-devolving-on-urinary-tract-infection
#2
REVIEW
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29774812/robot-assisted-simple-prostatectomy-by-an-extraperitoneal-approach
#3
Jens-Uwe Stolzenburg, Panagiotis Kallidonis, Iason Kyriazis, Dimitrios Kotsiris, Panteleimon Ntasiotis, Evangelos N Liatsikos
The incidence of symptomatic benign prostate hyperplasia and bladder outlet obstruction has increased during the last two decades. Most of men are treated conservatively. When medical therapy is inadequate to relief symptoms, surgical treatment is necessary. Absolute indications for surgical treatment are gross hematuria, recurrent urinary infections and retentions as well as bladder stones. With advent of minimally invasive surgery, large prostates tend to be treated either endoscopically or laparoscopically (including robotic assistance)...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29773014/investigations-of-phytochemical-constituents-and-their-pharmacological-properties-isolated-from-the-genus-urtica-critical-review-and-analysis
#4
Muhammad Ibrahim, Kanwal Rehman, Aneeza Razzaq, Iqbal Hussain, Tahir Farooq, Amjad Hussain, Muhammad Sajid Hamid Akash
The genus Urtica belongs to the family Urticaceae. The plants of this genus are known as nettles or, quite often, as stinging nettles. These plants can be easily identified by the presence of stinging hairs. Urtica species have previously been used for various medicinal purposes. The history for the use of these plants for medicinal purposes starts from the Bronze Age (3000-2000 BC). Medicinally, the genus Urtica has been used to treat several disorders, such as cancer, rheumatoid arthritis, bronchitis, diarrhea, sprains, kidney stones, urinary tract infection, high blood pressure, hemorrhoids, flu, cough, fever, and ulcers...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29772114/effect-of-highly-concentrated-hyaluronic-acid-chondroitin-sulfate-instillation-on-ureteral-stent-induced-discomfort-after-ureteroscopic-lithotripsy-a-multicenter-randomized-controlled-pilot-study
#5
Jung Ki Jo, Jae Heon Kim, Kyu Shik Kim, Jae Hoon Chung, Sung Yul Park, Yong Tae Kim, Hong Yong Choi, Eun-Seop Song, Bora Lee, Seung Wook Lee
OBJECTIVE: To investigate the efficacy and safety of instilling highly concentrated hyaluronic acid (HA)/chondroitin sulfate (CS) on the ureteral stent-related pain, urinary symptoms, and quality of life (QoL) of patients who underwent ureteroscopic lithotripsy for ureter stones followed by ureteral stent placement. PATIENTS AND METHODS: Eligible patients were randomly allocated to receive intravesical instillation with HA/CS or normal saline just after ureteral stent placement...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29770771/the-usefulness-of-agent-emission-imaging-high-mechanical-index-ultrasound-mode-in-the-diagnosis-of-urolithiasis-a-prospective-preliminary-study
#6
Artur Salmaslıoğlu, Mesut Bulakçı, Barış Bakır, Ravza Yılmaz, Yunus Emre Akpınar, Tzevat Tefik, Öner Şanlı, Sevda Özel, Bülent Acunas
PURPOSE: We aimed to determine the feasibility and effectiveness of agent emission imaging - high mechanical index (AEI-High MI) mode ultrasonography (US) compared with gray-scale and color Doppler US, alone or in combination, for the diagnosis of urolithiasis with reference to unenhanced computed tomography (CT). METHODS: This prospective study included 72 consecutive patients (40 males, 32 females; mean age, 45.9±14.7 years) referred by the department of urology for acute or elective symptoms of urolithiasis and confirmed to have urinary calculi on unenhanced abdominal CT, between January 2015 and June 2015...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29757578/seasonal-variations-in-urinary-calcium-volume-and-vitamin-d-in-kidney-stone-formers
#7
Kyrollis Attalla, Shubha De, Carl Sarkissian, Manoj Monga
OBJECTIVES: To investigate the seasonal variations in urinary calcium, serum vitamin D, and urinary volume in patients with a history of nephrolithiasis. MATERIALS AND METHODS: Patients included were those who completed a 24-hour urine metabolic evaluation on two occasions; one in summer (June-Aug) and one in winter (Nov-Jan), and who had not started any medications or been instructed on dietary modifications in the interval between the two tests that may have impacted the results...
May 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29748329/oral-antibiotic-exposure-and-kidney-stone-disease
#8
Gregory E Tasian, Thomas Jemielita, David S Goldfarb, Lawrence Copelovitch, Jeffrey S Gerber, Qufei Wu, Michelle R Denburg
Background Although intestinal and urinary microbiome perturbations are associated with nephrolithiasis, whether antibiotics are a risk factor for this condition remains unknown. Methods We determined the association between 12 classes of oral antibiotics and nephrolithiasis in a population-based, case-control study nested within 641 general practices providing electronic health record data for >13 million children and adults from 1994 to 2015 in the United Kingdom. We used incidence density sampling to match 25,981 patients with nephrolithiasis to 259,797 controls by age, sex, and practice at date of diagnosis (index date)...
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29747234/laparoscopic-nephrectomy-in-a-patient-with-severe-scoliosis-a-case-report
#9
Daichi Tamura, Ayato Ito, Daichi Kikuchi, Takashi Tsuyukubo, Renpei Kato, Yoichiro Kato, Susumu Konari, So Omori, Wataru Obara
Although the role of laparoscopic nephrectomy (LN) has been established, few studies have reported cases of LN in individuals with scoliosis. Here we report a case of right LN in a patient with severe right convex scoliosis. A 26-year-old man presented with a fever. His medical history comprised severe right convex lumbar scoliosis. CT revealed right hydronephrosis and right kidney stones. Pyelonephritis requiring nephrectomy was diagnosed. Right LN was feasible with elaborate perioperative care. The postoperative course was uneventful with no relapse of urinary tract infection...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29738031/influence-of-nutritional-status-laboratory-parameters-and-dietary-patterns-upon-urinary-acid-excretion-in-calcium-stone-formers
#10
Carolini Zanette Warmling Tessaro, Christiane Ishikawa Ramos, Ita Pfeferman Heilberg
INTRODUCTION: Obesity and Metabolic Syndrome (MS) are associated with low urinary pH and represent risk factors for nephrolithiasis, especially composed by uric acid. Acidogenic diets may also contribute to a reduction of urinary pH. Propensity for calcium oxalate precipitation has been shown to be higher with increasing features of the MS. OBJECTIVE: A retrospective evaluation of anthropometric and body composition parameters, MS criteria and the dietary patterns of overweight and obese calcium stone formers and their impact upon urinary pH and other lithogenic parameters was performed...
April 26, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29738024/urinary-ph-in-calcium-oxalate-stone-formers-does-it-matter
#11
EDITORIAL
Mauricio Carvalho
No abstract text is available yet for this article.
April 9, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29738008/does-fasting-in-ramadan-increase-the-risk-of-developing-urinary-stones
#12
Abdullah O Al Mahayni, Sultan S Alkhateeb, Ibrahim H Abusaq, Abdullah A Al Mufarrih, Muath I Jaafari, Amen A Bawazir
OBJECTIVES: To explore the frequency of renal colic (RC) secondary to urinary stones in Ramadan compared to other months and seasons of the year. METHODS: Retrospective cross-sectional study using medical records of 237 patients admitted through the emergency room (ER) with a diagnosis of RC secondary to urinary stones over a 10-year period at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. RESULTS: Patients fasting in Ramadan are 2 times more likely to present with a calculus of ureter as opposed to calculus in another location in the urinary tract, particularly when the holy month of Ramadan falls in the summer season...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29737631/a-fluid-structure-interaction-fsi-based-numerical-investigation-of-peristalsis-in-an-obstructed-human-ureter
#13
Ahmed Tasnub Takaddus, Prashanta Gautam, Abhilash J Chandy
Urine moves from the kidney to the bladder through the ureter. A series of compression waves facilitates this transport. Due to the highly concentrated mineral deposits in urine, stones are formed in the kidney and travel down through the urinary tract. While passing, a larger stone can get stuck and cause severe damage to ureter wall. Also, stones in the ureter obstructing the urine flow can cause pain and backflow of urine which in turn might require surgical intervention. The current study develops a 2D axisymmetric numerical model in order to gain an understanding of the ureter obstruction and its effects on the flow, which are critical in assessing the different treatment options...
May 8, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#14
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29736374/the-association-of-benign-prostatic-hyperplasia-with-lower-urinary-tract-stones-in-adult-men-a-retrospective-multicenter-study
#15
Jae Hung Jung, Jinsung Park, Won Tae Kim, Hong Wook Kim, Hyung Joon Kim, Sungwoo Hong, Hee Jo Yang, Hong Chung
Objective: To examine the relationship between benign prostatic hyperplasia (BPH) and the presence of lower urinary tract stones. Methods: We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period. We divided the patients into two groups based on the location of urinary stones: Group 1 (bladder calculi) and Group 2 (urethral calculi). We compared the characteristics of both groups and performed univariate and multivariate analyses with a logistic regression model to investigate the relationship between BPH and lower urinary tract stones...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29732006/low-dose-ct-with-adaptive-statistical-iterative-reconstruction-for-evaluation-of-urinary-stone
#16
Xiaohu Li, Hongmin Shu, Yifei Zhang, Xiaoshu Li, Jian Song, Junhua Du, Yinfeng Qian, Bin Liu, Yongqiang Yu
Purpose: To prospectively determine the diagnostic performance of low-dose CT (LDCT) with adaptive statistical iterative reconstruction (ASIR) technique for the detection of urinary stone disease. Results: The average DLP and ED was 408.16 ± 119.04 mGy and 6.12 ± 1.79 mSv in CDCT, and 138.19 ± 76.87 mGy and 2.07 ± 1.15 mSv in LDCT, respectively. The dose reduction rate of LDCT was nearly 66.1% for both DLP and ED ( P < 0.05). LDCT-80% ASIR images showed great image quality (mean score = 4...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730498/computer-aided-detection-of-ureteral-stones-in-thin-slice-computed-tomography-volumes-using-convolutional-neural-networks
#17
Martin Längkvist, Johan Jendeberg, Per Thunberg, Amy Loutfi, Mats Lidén
Computed tomography (CT) is the method of choice for diagnosing ureteral stones - kidney stones that obstruct the ureter. The purpose of this study is to develop a computer aided detection (CAD) algorithm for identifying a ureteral stone in thin slice CT volumes. The challenge in CAD for urinary stones lies in the similarity in shape and intensity of stones with non-stone structures and how to efficiently deal with large high-resolution CT volumes. We address these challenges by using a Convolutional Neural Network (CNN) that works directly on the high resolution CT volumes...
April 27, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29726091/factors-influencing-long-term-urinary-symptoms-following-prostate-brachytherapy
#18
Nelson N Stone, Jared S Winoker, Steven A Kaplan, Richard G Stock
OBJECTIVES: To determine which patient and treatment related factors were associated with increased AUA symptom score (AUASS) in men who presented with minimal symptoms prior to treatment for prostate cancer by permanent seed implantation. MATERIALS AND METHODS: Of 1842 men with a minimum follow-up of 5 years (mean 9.4) 1110 (60.3%) had initial AUASS of 0-7 and were treated with BT alone (n=491) or BT with hormone therapy (NHT) and or external beam irradiation (EBRT, n=619)...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29724204/efficacy-and-safety-of-pde5-is-and-%C3%AE-1-blockers-for-treating-lower-ureteric-stones-or-luts-a-meta-analysis-of-rcts
#19
Xifeng Sun, Wei Guan, Haoran Liu, Kun Tang, Libin Yan, Yangjun Zhang, Jin Zeng, Zhiqiang Chen, Hua Xu, Zhangqun Ye
BACKGROUND: Lower ureteric stones and lower urinary tract symptoms are common in urology.Drug treatment is one of standard therapy,but the efficacy was controversial.Thus we aimed to investigate the efficacy and safety of monotherapy or combination therapy of adrenoceptor1 blockers and phosphodiesterase5 inhibitors for treatment. METHODS: Randomized controlled trials up to November 2016 were retrieved from PubMed, the Cochrane Library, Web of Science and Embase...
May 3, 2018: BMC Urology
https://www.readbyqxmd.com/read/29719337/the-impact-of-stone-composition-on-renal-function
#20
Anmar Nassir, Hesham Saada, Taghreed Alnajjar, Jomanah Nasser, Waed Jameel, Soha Elmorsy, Hattan Badr
Background: Nephrolithiasis is a common condition that has various classifications according to stone composition. Stone formation can affect renal function; it can be a strong risk factor for chronic kidney disease (CKD). The main objective of this study is to explore the association between creatinine clearance and different stone compositions. Methods: This is a retrospective cohort study conducted in a tertiary center in Jeddah, Saudi Arabia, between 2005 and 2014...
April 2018: Urology Annals
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