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Lennon VA

Jiraporn Jitprapaikulsan, John J Chen, Eoin P Flanagan, W Oliver Tobin, Jim P Fryer, Brian G Weinshenker, Andrew McKeon, Vanda A Lennon, Jacqueline A Leavitt, Jan-Mendelt Tillema, Claudia Lucchinetti, B Mark Keegan, Orhun Kantarci, Cheryl Khanna, Sarah M Jenkins, Grant M Spears, Jessica Sagan, Sean J Pittock
PURPOSE: To determine the aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG) serostatus and visual outcomes in patients with recurrent optic neuritis (rON) initially seeking treatment. DESIGN: Cross-sectional cohort study. PARTICIPANTS: The study identified patients by searching the Mayo Clinic computerized central diagnostic index (January 2000-March 2017). The 246 eligible patients fulfilled the following criteria: (1) initially seeking treatment for at least 2 consecutive episodes of optic neuritis (ON) and (2) serum available for testing...
April 28, 2018: Ophthalmology
Jackson J Liang, Erin A Fender, Yong-Mei Cha, Ryan J Lennon, Abhiram Prasad, Gregory W Barsness
Guidelines do not recommend an implantable cardioverter defibrillator (ICD) for prevention of sudden death in patients who develop ventricular arrhythmia (VA) within 48 hours of acute myocardial infarction (AMI) if they are successfully revascularized. We aimed to determine long-term survival in a cohort of early VA survivors treated with percutaneous coronary intervention (PCI) and to determine whether certain high-risk characteristics predicted worse outcomes. This retrospective study included all patients with early VA after AMI treated with PCI at our institution from 2002 to 2012 who survived to hospital discharge...
March 1, 2016: American Journal of Cardiology
Stewart G Trost, Maria Fragala-Pinkham, Nancy Lennon, Margaret E O'Neil
PURPOSE: To develop and test decision tree (DT) models to classify physical activity (PA) intensity from accelerometer output and Gross Motor Function Classification System (GMFCS) classification level in ambulatory youth with cerebral palsy (CP) and compare the classification accuracy of the new DT models to that achieved by previously published cut points for youth with CP. METHODS: Youth with CP (GMFCS levels I-III) (N = 51) completed seven activity trials with increasing PA intensity while wearing a portable metabolic system and ActiGraph GT3X accelerometers...
May 2016: Medicine and Science in Sports and Exercise
Sean J Pittock, Vanda A Lennon, Andrew McKeon, Jay Mandrekar, Brian G Weinshenker, Claudia F Lucchinetti, Orna O'Toole, Dean M Wingerchuk
BACKGROUND: Complement activation after binding of an IgG autoantibody to aquaporin 4 (AQP4) is thought to be a major determinant of CNS inflammation and astrocytic injury in neuromyelitis optica. The aim of this study was to investigate the use of eculizumab--a therapeutic monoclonal IgG that neutralises the complement protein C5--in neuromyelitis optica spectrum disorders. METHODS: Between Oct 20, 2009, and Nov 3, 2010, we recruited patients from two US centres into an open-label trial...
June 2013: Lancet Neurology
M Matiello, V A Lennon, A Jacob, S J Pittock, C F Lucchinetti, D M Wingerchuk, B G Weinshenker
OBJECTIVE: To determine the prognostic value of neuromyelitis optica (NMO)-immunoglobulin G (IgG) in patients with recurrent optic neuritis (ON). The aquaporin-4-specific serum autoantibody, NMO-IgG, is a biomarker for NMO and relapsing transverse myelitis. Recurrent ON may herald multiple sclerosis (MS) or NMO, or it may occur as an isolated syndrome. The prognosis and response to therapy differs in each of these contexts. METHODS: We evaluated 34 patients who were tested for NMO-IgG between 2000 and 2007 and who had two or more episodes of ON without satisfying a diagnosis of MS or NMO prior to serologic testing...
June 3, 2008: Neurology
Amy M Kilbourne, Marcela Horvitz-Lennon, Edward P Post, John F McCarthy, Mario Cruz, Deborah Welsh, Frederic C Blow
OBJECTIVES: We evaluated patient and medication treatment factors associated with self-reported oral health status in patients diagnosed with serious mental illness (SMI) in a large, national sample of patients in the Veterans Affairs (VA) health system. METHODS: 4,769 patients (mean age = 55, 7.8 percent women) were included from the VA's 1999 National Psychosis Registry (NPR) for whom the oral health information gathered by the VA's Large Health Survey of Veterans was available...
2007: Journal of Public Health Dentistry
P F Lennon, L L Schulman, Y Enson
We have examined the effect of chronic airways obstruction on the measurement of the single-breath carbon-monoxide-diffusing capacity (DLCLSB). We reviewed the results of 136 consecutive pulmonary function tests (comprising standard spirometry, helium dilution lung volumes and DLCOSB) obtained in patients who had an FEV1/FVC less than 70%. We calculated DLCOSB using two different values for alveolar volume (VA). In the first method (HeDL), VA was measured by single-breath dilution of helium during the test...
1987: Respiration; International Review of Thoracic Diseases
L L Schulman, P F Lennon, S J Ratner, Y Enson
To assess the role of vasoactive prostanoids in acute lung injury, we studied 16 dogs after intravenous injection of oleic acid (OA; 0.08 ml/kg). Animals were ventilated with 100% O2 and zero end-expiratory pressure. Base-line hemodynamic and blood gas observations were obtained 90-120 min following OA. Observations were repeated 30 min after infusion of meclofenamate (2 mg/kg; n = 10), or after saline (n = 6). Resistance to pulmonary blood flow was assessed using the difference between pulmonary arterial diastolic and left atrial pressures (PDG)...
February 1988: Journal of Applied Physiology
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