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Vincent A

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https://www.readbyqxmd.com/read/27911332/type-0-spinal-muscular-atrophy-further%C3%A2-delineation-of-prenatal-and%C3%A2-postnatal-features-in-16-patients
#1
Sarah Grotto, Jean-Marie Cuisset, Stéphane Marret, Séverine Drunat, Patricia Faure, Séverine Audebert-Bellanger, Isabelle Desguerre, Vincent Flurin, Anne-Gaëlle Grebille, Anne-Marie Guerrot, Hubert Journel, Gilles Morin, Ghislaine Plessis, Sylvain Renolleau, Joëlle Roume, Brigitte Simon-Bouy, Renaud Touraine, Marjolaine Willems, Thierry Frébourg, Eric Verspyck, Pascale Saugier-Veber
BACKGROUND: Spinal muscular atrophy (SMA) is caused by homozygous inactivation of the SMN1 gene. The SMN2 copy number modulates the severity of SMA. The 0SMN1/1SMN2 genotype, the most severe genotype compatible with life, is expected to be associated with the most severe form of the disease, called type 0 SMA, defined by prenatal onset. OBJECTIVE: The aim of the study was to review clinical features and prenatal manifestations in this rare SMA subtype. METHODS: SMA patients with the 0SMN1/1SMN2 genotype were retrospectively collected using the UMD-SMN1 France database...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27910979/efficient-synthesis-of-cysteine-rich-cyclic-peptides-through-intramolecular-native-chemical-ligation-of-n-hnb-cys-peptide-crypto-thioesters
#2
Victor P Terrier, Agnès F Delmas, Vincent Aucagne
We herein introduce a straightforward synthetic route to cysteine-containing cyclic peptides based on the intramolecular native chemical ligation of in situ generated thioesters. Key precursors are N-Hnb-Cys crypto-thioesters, easily synthesized by Fmoc-based SPPS. The strategy is applied to a representative range of naturally occurring cyclic disulfide-rich peptide sequences.
December 2, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27910883/the-mechanism-of-transactivation-regulation-due-to-polymorphic-short-tandem-repeats-strs-using-igf1-promoter-as-a-model
#3
Holly Y Chen, Suk Ling Ma, Wei Huang, Lindan Ji, Vincent H K Leung, Honglin Jiang, Xiaoqiang Yao, Nelson L S Tang
Functional short tandem repeats (STR) are polymorphic in the population, and the number of repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR in IGF1 promoter has been extensively studied for its association with IGF1 concentration in blood and various clinical traits and represents an important eSTR. We previously used an in-vitro luciferase reporter model to examine the interaction between STRs and SNPs in IGF1 promoter. Here, we further explored the mechanism how the number of repeats of the STR regulates gene transcription...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910805/ebola-virus-vaccines-where-do-we-stand
#4
REVIEW
Vincent Pavot
The recent outbreak of Ebola virus disease in West Africa has led to more than 11,000 deaths, with a peak in mortality from August through December of 2014. A meeting convened by the World Health Organization (WHO) in September 2014, concluded that an urgent unmet need exists for efficacy and safety testing of the Ebola virus vaccine candidates and that clinical trials should be expedited. These vaccines could be used both in an outbreak setting and to provide long-term protection in populations at risk of sporadic outbreaks...
October 28, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27909946/norovirus-gii-17-outbreak-linked-to-an-infected-post-symptomatic-food-worker-in-a-french-military-unit-located-in-france
#5
Marc-Antoine Sanchez, Simon-Pierre Corcostégui, Charles-Arnaud De Broucker, Olivier Cabre, Stéphanie Watier-Grillot, Sylvie Perelle, Katia Ambert-Balay, Vincent Pommier de Santi
In February 2016, an outbreak of gastroenteritis occurred in a French military unit located in Poitiers, France. Attack rate was of 34% (103/300). A case-control study identified association between illness and cake consumption. Stool samples were tested positive for Norovirus GII.17 for one patient and one post-symptomatic food worker (FW). The FW presented vomiting one day before cake preparation. The NoV strain was probably spread through food worker hand contact. Prevention of Norovirus foodborne outbreaks implies new guidelines for FWs management in France and Europe...
December 1, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27909877/association-between-mental-health-staffing-level-and-primary-care-mental-health-integration-level-on-provision-of-depression-care-in-veteran-s-affairs-medical-facilities
#6
Denise C Cooper, Christian D Helfrich, Stephen M Thielke, Ranak B Trivedi, Karin M Nelson, Gayle E Reiber, Evercita C Eugenio, Kristine Beaver, Julie Nugent-Carney, Vincent S Fan
We examined the association of mental health staffing and the utilization of primary care/mental health integration (PCMHI) with facility-level variations in adequacy of psychotherapy and antidepressants received by Veterans with new, recurrent, and chronic depression. Greater likelihood of adequate psychotherapy was associated with increased (1) PCMHI utilization by recurrent depression patients (AOR 1.02; 95% CI 1.00, 1.03); and (2) staffing for recurrent (AOR 1.03; 95% CI 1.01, 1.06) and chronic (AOR 1.02; 95% CI 1...
December 1, 2016: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/27909798/the-loading-of-condensin-in-the-context-of-chromatin
#7
REVIEW
Xavier Robellet, Vincent Vanoosthuyse, Pascal Bernard
The packaging of DNA into chromosomes is a ubiquitous process that enables living organisms to structure and transmit their genome accurately through cell divisions. In the three kingdoms of life, the architecture and dynamics of chromosomes rely upon ring-shaped SMC (Structural Maintenance of Chromosomes) condensin complexes. To understand how condensin rings organize chromosomes, it is essential to decipher how they associate with chromatin filaments. Here, we use recent evidence to discuss the role played by nucleosomes and transcription factors in the loading of condensin at transcribed genes...
December 1, 2016: Current Genetics
https://www.readbyqxmd.com/read/27909380/knowledge-attitudes-and-current-practices-of-canadian-physiotherapists-in-preventing-and-managing-diabetes
#8
Karly Doehring, Scott Durno, Catherine Pakenham, Bashir Versi, Vincent G DePaul
Purpose: To describe the knowledge, attitudes, and current practices of Canadian physiotherapists in preventing and managing diabetes. Methods: Members of the Canadian Physiotherapy Association were recruited by email to participate in a Web-based survey. The survey contained 40 items in four domains: demographics and education, attitudes and beliefs, current practices, and knowledge of diabetes. A descriptive analysis was completed for all the response variables from the survey. Results: A total of 401 physiotherapists from 10 provinces and 2 territories participated...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27909374/cardiorespiratory-physiotherapy-around-the-clock-experience-at-a-university-hospital
#9
Marianne Devroey, Catherine Buyse, Michelle Norrenberg, Anne-Marie Ros, Jean-Louis Vincent
Purpose: To document and describe the use of a hospital-wide, 24-hour cardiorespiratory physiotherapy service run by an intensive care unit (ICU) team of physiotherapists. Methods: We prospectively collected data on all non-ICU hospital patients who used the 24-hours-per-day cardiorespiratory physiotherapy service over a 1-year period between July 2013 and June 2014. The ICU physiotherapists documented the reason, origin of referral, time of call, and type and frequency of treatment of each patient. Results: Over the 1-year period, the ICU physiotherapists administered 2,192 out-of-hours cardiorespiratory physiotherapy treatments (n=685 patients) outside the ICU...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27908944/use-of-neuromuscular-blockers-during-therapeutic-hypothermia-after-cardiac-arrest-a-nursing-protocol
#10
Coraline Boulila, Samia Ben Abdallah, Aude Marincamp, Vincent Coic, Romuald Lauverjat, Nicole Ericher, Wulfran Bougouin, Jean-Paul Mira, Alain Cariou, Guillaume Geri
BACKGROUND: Neuromuscular blockers used to prevent shivering during therapeutic hypothermia in comatose patients after out-of-hospital cardiac arrest are associated with adverse events. OBJECTIVE: To assess the influence of a nurse-implemented protocol on use of neuromuscular blockers in patients treated with 24-hour therapeutic hypothermia after out-of-hospital cardiac arrest. METHODS: A before and after study was done in a 24-bed cardiac arrest center...
December 2016: Critical Care Nurse
https://www.readbyqxmd.com/read/27908668/associations-between-urinary-biomarkers-of-oxidative-stress-and-air-pollutants-observed-in-a-randomized-crossover-exposure-to-steel-mill-emissions
#11
Guillaume Pelletier, Marc Rigden, Lisa Marie Kauri, Robin Shutt, Mamun Mahmud, Sabit Cakmak, Premkumari Kumarathasan, Errol M Thomson, Renaud Vincent, Gayle Broad, Ling Liu, Robert Dales
The effects of industrial air pollution on human health have not been as thoroughly investigated as those of urban air pollution which originates mostly from automotive transport. To better assess the health impacts of point sources of industrial air pollution, a randomized crossover exposure study was conducted. Sixty one young and healthy volunteers were randomly assigned to spend five consecutive eight-hour days near a steel mill or at a location five kilometres away. After a nine or sixteen-day washout period, volunteers spent another five consecutive days at the second site...
November 25, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27908632/risk-of-persistent-and-recurrent-cervical-neoplasia-following-incidentally-detected-adenocarcinoma-in-situ
#12
Aime Munro, Jim Codde, Katrina Spilsbury, Nerida Steel, Colin J R Stewart, Stuart G Salfinger, Jason Tan, Ganendra R Mohan, Yee Leung, James Semmens, Peter O'Leary, Vincent Williams, Paul A Cohen
BACKGROUND: Adenocarcinoma-in-situ (AIS) of the uterine cervix is a precursor to cervical adenocarcinoma and may co-exist with both adenocarcinoma and high-grade squamous dysplasia (cervical intraepithelial neoplasia (CIN) 2 and 3). Up to 60% of AIS lesions are detected incidentally following excisional biopsies performed for the treatment of CIN 2/3. To date there are no data regarding risk factors for persisting or progressive cervical neoplasia in these patients. OBJECTIVE: To investigate patient outcomes following incidentally detected cervical AIS after loop electrosurgical excision procedure (LEEP) or cold knife cone (CKC) biopsy performed for the treatment of high-grade cervical intraepithelial neoplasia (CIN)...
November 28, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27908148/local-attenuation-curve-optimization-framework-for-high-quality-perfusion-maps-in-low-dose-cerebral-perfusion-ct
#13
Vincent Van Nieuwenhove, Geert Van Eyndhoven, K Joost Batenburg, Nico Buls, Jef Vandemeulebroucke, Jan De Beenhouwer, Jan Sijbers
PURPOSE: Cerebral perfusion x-ray computed tomography (PCT) is a powerful tool for noninvasive imaging of hemodynamic information throughout the brain. Conventional PCT requires the brain to be imaged multiple times during the perfusion process, and hence radiation dose is a major concern. The authors propose a PCT reconstruction algorithm that allows for lowering the dose while maintaining a high quality of the perfusion maps. It relies on an accurate estimation of the arterial input function (AIF), which in turn depends on the quality of the attenuation curves in the arterial region...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27907884/factors-determining-human-to-human-transmissibility-of-zoonotic-pathogens-via-contact
#14
REVIEW
Mathilde Richard, Sascha Knauf, Philip Lawrence, Alison E Mather, Vincent J Munster, Marcel A Müller, Derek Smith, Thijs Kuiken
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission...
November 28, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27907072/carers-medication-administration-errors-in-the-domiciliary-setting-a-systematic-review
#15
Anam Parand, Sara Garfield, Charles Vincent, Bryony Dean Franklin
PURPOSE: Medications are mostly taken in patients' own homes, increasingly administered by carers, yet studies of medication safety have been largely conducted in the hospital setting. We aimed to review studies of how carers cause and/or prevent medication administration errors (MAEs) within the patient's home; to identify types, prevalence and causes of these MAEs and any interventions to prevent them. METHODS: A narrative systematic review of literature published between 1 Jan 1946 and 23 Sep 2013 was carried out across the databases EMBASE, MEDLINE, PSYCHINFO, COCHRANE and CINAHL...
2016: PloS One
https://www.readbyqxmd.com/read/27906922/the-effectiveness-of-hyperbaric-oxygen-therapy-hbot-in-radiation-induced-haemorrhagic-cystitis
#16
Vincent Chong, Michael Rice
INTRODUCTION: Radiation cystitis is one of the possible complications from pelvic radiotherapy. Hyperbaric oxygen (HBOT) improves tissue oxygenation and healing of scarred tissue. AIMS: To assess the efficacy of hyperbaric oxygen therapy (HBOT) in the management of radiation-induced haemorrhagic cystitis in patients with urological cancers. METHODS: This is a retrospective review on all patients with macroscopic haematuria secondary to radiation induced haemorrhagic cystitis who were treated with hyperbaric oxygen therapy (HBOT) between 2009 and 2013...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27906808/the-accuracy-of-large-loop-excision-of-the-transformation-zone-specimen-dimensions-in-determining-volume-a-multicentric-prospective-observational-study
#17
Xavier Carcopino, Julien Mancini, Walter Prendiville, Jean Gondry, Julien Chevreau, Gery Lamblin, Anthony Atallah, Vincent Lavoue, Claire Caradec, Jean-Jacques Baldauf, Angélique Bryand, Sébastien Henno, Aubert Agostini, Serge Douvier, Adelaide Jarniat, Didier Riethmuller, Anne Mendel, Jean-Luc Brun, Hajanarina Rakotomahenina, Lise Preaubert
OBJECTIVE: The aim of the study was to determine which mathematical formula of specimen dimensions is the most accurate method of determining volume of the excised specimen at loop excision of the transformation zone. MATERIALS AND METHODS: A multicenter prospective observational study was conducted. A total of 258 patients who had a loop excision of the transformation zone performed as treatment of cervical intraepithelial neoplasia 2-3 were included. The dimensions and the volume of the specimen were measured at the time of the procedure, before formaldehyde fixation...
November 30, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27906302/bichromatic-homodyne-detection-of-broadband-quadrature-squeezing
#18
Christopher S Embrey, Joshua Hordell, Plamen G Petrov, Vincent Boyer
We experimentally study a homodyne detection technique for the characterization of a quadrature squeezed field where the correlated bands, here created by four-wave mixing in a hot atomic vapor, are separated by a large frequency gap of more than 6 GHz. The technique uses a two-frequency local oscillator to detect the fluctuations of the correlated bands at a frequency accessible to the detection electronics. Working at low detection frequency, the method allows for the determination of both the amplitude and the phase of the squeezing spectrum...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906031/contrasting-biological-potency-of-particulate-matter-collected-at-sites-impacted-by-distinct-industrial-sources
#19
Errol M Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Ngoc Q Vuong, Ewa Dabek-Zlotorzynska, Valbona Celo, Jean-Pierre Charland, Prem Kumarathasan, Jeffrey R Brook, Renaud Vincent
BACKGROUND: Industrial sources contribute a significant proportion of anthropogenic particulate matter (PM) emissions, producing particles of varying composition that may differentially impact health. This study investigated the in vitro toxicity of ambient PM collected near industrial sites in relation to particle size and composition. METHODS: Size-fractionated particles (ultrafine, PM0.1-2.5, PM2.5-10, PM>10) were collected in the vicinity of steel, copper, aluminium, and petrochemical industrial sites...
December 1, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27905991/ethnic-differences-in-prevalence-and-risk-factors-for-hypertension-in-the-suriname-health-study-a-cross-sectional-population-study
#20
Ingrid S K Krishnadath, Vincent W V Jaddoe, Lenny M Nahar-van Venrooij, Jerry R Toelsie
BACKGROUND: Limited information is available about the prevalence, ethnic disparities, and risk factors of hypertension within developing countries. We used data from a nationwide study on non-communicable disease (NCD) risk factors to estimate, explore, and compare the prevalence of hypertension overall and in subgroups of risk factors among different ethnic groups in Suriname. METHOD: The Suriname Health Study used the World Health Organization Steps design to select respondents with a stratified multistage cluster sample of households...
September 17, 2016: Population Health Metrics
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