keyword
MENU ▼
Read by QxMD icon Read
search

Vincent A

keyword
https://www.readbyqxmd.com/read/29161709/impact-of-local-and-systemic-factors-on-kidney-dysfunction-in-bardet-biedl-syndrome
#1
Miriam Zacchia, Giovanna Capolongo, Francesco Trepiccione, Vincent Marion
Bardet Biedl syndrome (BBS) is a rare inherited syndromic condition characterized by renal and extra-renal disorders. Renal defect, at either structural or functional level, is one of the cardinal clinical features, and is a major cause of morbidity. However, the pathogenic mechanism underlying its dysfunction remains largely unknown, and to date only symptomatic treatment with no specific therapy is available for these patients. Elucidating aberrant cellular and/or systemic processes that impact kidney function is therefore a prerequisite to develop targeted innovative therapeutic strategies for the BBS patients...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29160938/-knitting-through-the-mesh-novel-single-channel-troubleshooter-technique-for-dilation-assisted-transstricture-retrieval-of-a-migrated-gastroduodenal-stent
#2
Vincent Zimmer
Gastroduodenal stenting using self-expandable metallic stents (SEMSs) represents a viable endoscopic option for palliative treatment of gastric outlet obstruction (GOO), less invasive relative to surgical and/or endoscopic ultrasound-guided gastroenterostomy (EUS-GE). Nevertheless, high rates of stent dysfunction remain a significant Achilles' heel of the procedure. Endoscopic removal of a distally migrated gastroduodenal stent remains challenging with single-channel techniques, calling for individually tailored solutions vis-à-vis the inevitable upstream stricture...
November 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29160716/-and-ecarlottones-uncommon-chalconoids-from-fissistigma-latifolium-with-pro-apoptotic-activity
#3
Charlotte Gény, Alma Abou Samra, Pascal Retailleau, Bogdan I Iorga, Hristo Nedev, Khalijah Awang, Fanny Roussi, Marc Litaudon, Vincent Dumontet
Four new compounds, (+)- and (-)-ecarlottone (1), (±)-fislatifolione (5), (±)-isofislatifolione (6), and (±)-fislatifolic acid (7), and the known desmethoxyyangonin (2), didymocarpin-A (3), and dehydrodidymocarpin-A (4) were isolated from the stem bark of Fissistigma latifolium, by means of bioassay-guided purification using an in vitro affinity displacement assay based on the modulation of Bcl-xL/Bak and Mcl-1/Bid interactions. The structures of the new compounds were elucidated by NMR spectroscopic data analysis, and the absolute configurations of compounds (+)-1 and (-)-1 were assigned by comparison of experimental and computed ECD spectra...
November 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29160306/discovery-of-a-big-void-in-khufu-s-pyramid-by-observation-of-cosmic-ray-muons
#4
Kunihiro Morishima, Mitsuaki Kuno, Akira Nishio, Nobuko Kitagawa, Yuta Manabe, Masaki Moto, Fumihiko Takasaki, Hirofumi Fujii, Kotaro Satoh, Hideyo Kodama, Kohei Hayashi, Shigeru Odaka, Sébastien Procureur, David Attié, Simon Bouteille, Denis Calvet, Christopher Filosa, Patrick Magnier, Irakli Mandjavidze, Marc Riallot, Benoit Marini, Pierre Gable, Yoshikatsu Date, Makiko Sugiura, Yasser Elshayeb, Tamer Elnady, Mustapha Ezzy, Emmanuel Guerriero, Vincent Steiger, Nicolas Serikoff, Jean-Baptiste Mouret, Bernard Charlès, Hany Helal, Mehdi Tayoubi
The Great Pyramid or Khufu's Pyramid was built on the Giza Plateau (Egypt) during the IV(th) dynasty by the pharaoh Khufu (Cheops), who reigned from 2509 to 2483 BC(1). Despite being one of the oldest and largest monuments on Earth, there is no consensus about how it was built(2,3). To better understand its internal structure, we imaged the pyramid using muons, which are by-products of cosmic rays that are only partially absorbed by stone(4-6). The resulting cosmic-ray muon radiography allows us to visualize the known and potentially unknown voids in the pyramid in a non-invasive way...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29159936/influence-of-socioeconomic-factors-and-distance-to-radiotherapy-on-breast-conserving-surgery-rates-for-early-breast-cancer-in-regional-australia-implications-of-change
#5
Ian M Collins, Caroline Lum, Vincent L Versace
AIMS: Breast conserving surgery rates are affected by many factors including distance to radiotherapy and tumor-related features. Numerous studies have found women who must travel further for radiotherapy are more likely to choose mastectomy and avoid radiotherapy. We examined relationships between socioeconomic group, distance to radiotherapy services and mastectomy rates across a range of rural and metropolitan settings. METHODS: We used a dataset extracted from the Evaluation of Cancer Outcomes Barwon South Western Registry, which captured data on new breast cancer diagnoses in the southwest region of Victoria, Australia...
November 21, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159928/the-immunogenetics-of-neurological-disease
#6
REVIEW
Maneesh K Misra, Vincent Damotte, Jill A Hollenbach
Genes encoding antigen-presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin-like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis...
November 21, 2017: Immunology
https://www.readbyqxmd.com/read/29159873/orthopaedic-manifestations-within-the-22q11-2-deletion-syndrome-a-systematic-review
#7
Jelle F Homans, Isabel N Tromp, Dino Colo, Tom P C Schlösser, Moyo C Kruyt, Vincent F X Deeney, Terrence B Crowley, Donna M McDonald-McGinn, René M Castelein
The 22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion syndrome with an estimated prevalence of 1:4,000 live births. 22q11.2DS is known to have wide phenotypic variability, including orthopaedic manifestations. The purpose of this systematic review is to increase the awareness of orthopaedic manifestations associated with 22q11.2DS. This systematic review was performed according to the PRISMA Guidelines. Original epidemiological studies on the prevalence of orthopaedic manifestations within 22q11...
November 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29159855/b1-artifact-reduction-in-abdominal-dce-mri-using-kt-points-first-clinical-assessment-of-dynamic-rf-shimming-at-3t
#8
Raphaël Tomi-Tricot, Vincent Gras, Franck Mauconduit, François Legou, Nicolas Boulant, Matthias Gebhardt, Dieter Ritter, Berthold Kiefer, Pierre Zerbib, Alain Rahmouni, Alexandre Vignaud, Alain Luciani, Alexis Amadon
BACKGROUND: The excitation inhomogeneity artifact occurring at 3T in the abdomen can lead to dramatic loss of signal and contrast, thereby hampering diagnosis. PURPOSE: To assess excitation homogeneity and image quality achieved by nonselective prototypical kT -points pulses, compared to tailored static RF shimming, in clinical routine on a commercial dual-transmit scanner. STUDY TYPE: Retrospective study with Institutional Review Board approval; informed consent was waived...
November 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29159475/correction-to-a-phase-i-randomized-single-dose-study-evaluating-the-pharmacokinetic-equivalence-of-biosimilar-abp-215-and-bevacizumab-in-healthy-adult-men
#9
Richard Markus, Vincent Chow, Zhiying Pan, Vladimir Hanes
The article [A phase I, randomized, single-dose study evaluating the pharmacokinetic equivalence of biosimilar ABP 215 and bevacizumab in healthy adult men].
November 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29158957/relationship-of-preseason-movement-screens-with-overuse-symptoms-in-collegiate-baseball-players
#10
Andrew M Busch, Daniel R Clifton, James A Onate, Vincent K Ramsey, Fred Cromartie
Background: The shoulder mobility screen of the Functional Movement Screen™ (FMS™) and the upper extremity patterns of the Selective Functional Movement Assessment (SFMA) assess global, multi-joint movement capabilities in the upper-extremities. Identifying which assessment can most accurately determine if baseball players are at an increased risk of experiencing overuse symptoms in the shoulder or elbow throughout a competitive season may reduce throwing-related injuries requiring medical attention...
November 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29158426/cohesin-function-in-cohesion-condensation-and-dna-repair-is-regulated-by-wpl1p-via-a-common-mechanism-in-saccharomyces%C3%A2-cerevisiae
#11
Michelle S Bloom, Douglas Koshland, Vincent Guacci
Cohesin tethers DNA to mediate sister chromatid cohesion, chromosome condensation, and DNA repair. How the cell regulates cohesin to perform these distinct functions remains to be elucidated. One cohesin regulator, Wpl1p, was characterized in Saccharomyces cerevisiae as a promoter of efficient cohesion and an inhibitor of condensation. Wpl1p is also required for resistance to DNA damaging agents. Here we provide evidence that Wpl1p promotes the timely repair of DNA damage induced during S-phase. Previous studies indicate that Wpl1p destabilizes cohesin's binding to DNA by modulating the interface between the cohesin subunits Mcd1p and Smc3p...
November 20, 2017: Genetics
https://www.readbyqxmd.com/read/29158396/emt-programs-promote-basal-mammary-stem-cell-and-tumor-initiating-cell-stemness-by-inducing-primary-ciliogenesis-and-hedgehog-signaling
#12
Vincent J Guen, Tony E Chavarria, Cornelia Kröger, Xin Ye, Robert A Weinberg, Jacqueline A Lees
Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain carcinomas depends on a small subset of tumor cells, called "tumor-initiating cells" (TICs), with SC-like properties. Mammary SCs (MaSCs) reside in the basal compartment of the mammary epithelium, and their neoplastic counterparts, mammary TICs (MaTICs), are thought to serve as the TICs for the claudin-low subtype of breast cancer...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29157936/short-parietal-lobe-connections-of-the-human-and-monkey-brain
#13
Marco Catani, Naianna Robertsson, Ahmad Beyh, Vincent Huynh, Francisco de Santiago Requejo, Henrietta Howells, Rachel L C Barrett, Marco Aiello, Carlo Cavaliere, Tim B Dyrby, Kristine Krug, Maurice Ptito, Helen D'Arceuil, Stephanie J Forkel, Flavio Dell'Acqua
The parietal lobe has a unique place in the human brain. Anatomically, it is at the crossroad between the frontal, occipital, and temporal lobes, thus providing a middle ground for multimodal sensory integration. Functionally, it supports higher cognitive functions that are characteristic of the human species, such as mathematical cognition, semantic and pragmatic aspects of language, and abstract thinking. Despite its importance, a comprehensive comparison of human and simian intraparietal networks is missing...
November 2, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29157922/development-and-electronic-validation-of-the-revised-cystic-fibrosis-questionnaire-cfq-r-teen-adult-new-tool-for-monitoring-psychosocial-health-in-cf
#14
Amparo Solé, Casilda Olveira, Ines Pérez, David Hervás, Vincent Valentine, Anick N Baca Yepez, Gabriel Olveira, Alexandra L Quittner
BACKGROUND: The Cystic Fibrosis Questionnaire-Revised (CFQ-R+14) is a disease-specific, health-related quality of life instrument for cystic fibrosis (CF) patients ≥14years. We have developed a Spanish electronic version of the CFQ-R (e-CFQ-R+14 Spain). Our aim was to compare the paper and electronic versions and to validate the electronic version. METHODS: Fifty CF patients completed the study. All answered the paper and electronic versions on day 1 and repeated the e-CFQR version 15days later...
November 17, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29157864/new-caspase-1-inhibitor-by-scaffold-hopping-into-bio-inspired-3d-fragment-space
#15
Anne Brethon, Laurent Chantalat, Olivier Christin, Laurence Clary, Jean-François Fournier, Marcus Gastreich, Craig S Harris, Tatiana Isabet, Jonathan Pascau, Etienne Thoreau, Didier Roche, Vincent Rodeschini
Virtual fragmentation of a library of 12,000 compounds inspired by natural products led to a dataset of 153,000 fragments that was used as a source to identify effective P2-P3 scaffold replacement solutions for peptidic Caspase-1 inhibitors. Our strategy led to the identification of an original 2-azabicyclo-octane scaffold (2-ABO) that was further elaborated into the potent Caspase-1 inhibitor CD10847 (IC50 = 17 nM). The crystal structure of Caspase-1 in complex with CD10847 was obtained, and its binding mode was shown to be similar to the one predicted by docking and in good agreement with other known inhibitors...
November 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29157032/pain-fatigue-function-and-participation-among-long-term-manual-wheelchair-users-partnered-with-a-mobility-service-dog
#16
Claude Vincent, Dany H Gagnon, Frédéric Dumont
PURPOSE: To assess the effects of a mobility service dog (MSD) on pain, fatigue, wheelchair-related functional tasks, participation and satisfaction among manual wheelchair users over a nine-month period. METHOD: A longitudinal study with repeated assessment times before and three, six and nine months after intervention was achieved. Intervention consisted in partnering each participant with a MSD. The setting is a well-established provincial service dog training school and participants homes...
November 20, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29156770/sco-spondin-oligopeptide-inhibits-angiogenesis-in-glioblastoma
#17
Romain Bibes, Stéphane Gobron, François Vincent, Carole Mélin, Nicolas Vedrenne, Aurélie Perraud, Francois Labrousse, Marie-Odile Jauberteau, Fabrice Lalloué
Angiogenesis plays a critical role in glioblastoma growth and progression. We therefore aimed at evaluating the anti-angiogenic properties of an oligopeptide originating from SCO-spondin (NX) on a model of human glioblastoma. To this end, we studied the impact of NX treatment on human brain endothelial cells (HBMECs) alone or co-cultured with glioblastoma cells (U87-MG) on apoptosis, proliferation, migration and release of angiogenic factors. We further investigated the anti-angiogenic potential of NX on human glioblastoma cells grown on chorio-allantoic membrane (CAM) or in glioblastoma xenografts...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156585/pan-cellulosomics-of-mesophilic-clostridia-variations-on-a-theme
#18
Bareket Dassa, Ilya Borovok, Vincent Lombard, Bernard Henrissat, Raphael Lamed, Edward A Bayer, Sarah Moraïs
The bacterial cellulosome is an extracellular, multi-enzyme machinery, which efficiently depolymerizes plant biomass by degrading plant cell wall polysaccharides. Several cellulolytic bacteria have evolved various elaborate modular architectures of active cellulosomes. We present here a genome-wide analysis of a dozen mesophilic clostridia species, including both well-studied and yet-undescribed cellulosome-producing bacteria. We first report here, the presence of cellulosomal elements, thus expanding our knowledge regarding the prevalence of the cellulosomal paradigm in nature...
November 18, 2017: Microorganisms
https://www.readbyqxmd.com/read/29156311/impacts-from-urban-water-systems-on-receiving-waters-how-to-account-for-severe-wet-weather-events-in-lca
#19
Eva Risch, Johnny Gasperi, Marie-Christine Gromaire, Ghassan Chebbo, Sam Azimi, Vincent Rocher, Philippe Roux, Ralph K Rosenbaum, Carole Sinfort
Sewage systems are a vital part of the urban infrastructure in most cities. They provide drainage, which protects public health, prevents the flooding of property and protects the water environment around urban areas. On some occasions sewers will overflow into the water environment during heavy rain potentially causing unacceptable impacts from releases of untreated sewage into the environment. In typical Life Cycle Assessment (LCA) studies of urban wastewater systems (UWS), average dry-weather conditions are modelled while wet-weather flows from UWS, presenting a high temporal variability, are not currently accounted for...
October 23, 2017: Water Research
https://www.readbyqxmd.com/read/29155894/estimating-virus-effective-population-size-and-selection-without-neutral-markers
#20
Elsa Rousseau, Benoît Moury, Ludovic Mailleret, Rachid Senoussi, Alain Palloix, Vincent Simon, Sophie Valière, Frédéric Grognard, Frédéric Fabre
By combining high-throughput sequencing (HTS) with experimental evolution, we can observe the within-host dynamics of pathogen variants of biomedical or ecological interest. We studied the evolutionary dynamics of five variants of Potato virus Y (PVY) in 15 doubled-haploid lines of pepper. All plants were inoculated with the same mixture of virus variants and, variant frequencies were determined by HTS in eight plants of each pepper line, at each of six sampling dates. We developed a method for estimating the intensities of selection and genetic drift in a multi-allelic Wright-Fisher model, applicable whether these forces are strong or weak, and in the absence of neutral markers...
November 20, 2017: PLoS Pathogens
keyword
keyword
36481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"