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https://www.readbyqxmd.com/read/28806338/isolated-second-implant-adaptation-period-in-sequential-cochlear-implantation-in-adults
#1
Kari Smilsky, Peter R Dixon, Leah Smith, David Shipp, Amy Ng, Tara Millman, Suzanne Stewart, Julian M Nedzelski, Vincent Y Lin, Joseph M Chen
OBJECTIVE: To determine if depriving the use of the first cochlear implant (CI1) impacts adaptation to a sequential implant (CI2). STUDY DESIGN: Prospective cohort. SETTING: Academic center. PATIENTS: Sixteen unilateral cochlear implant recipients undergoing contralateral implantation (sequential bilateral) were matched according to age, etiology, duration of deafness, device age, and delay between implants. INTERVENTION: During a 4-week adaptation period after CI2 activation, patients underwent deprivation of CI1 or were permitted continued use of it...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806332/linking-deafness-and-dementia-challenges-and-opportunities
#2
Vincent Y W Lin, Sandra E Black
: The rising incidence of dementia locally and worldwide has now reached a critical level. The associated costs associated with these individuals will ultimately be untenable to most societies. Furthermore there is a paucity of highly effective treatments. However, the recent discovery of the association of hearing loss and dementia may open many potential opportunities. Although we still are acquiring knowledge on the pathophysiology of this association, clinicians are hopeful that our current highly effective treatments of hearing loss may ultimately be shown to have a positive effect on those with dementia...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28805634/honey-bee-gut-dysbiosis-a-novel-context-of-disease-ecology
#3
REVIEW
Kirk E Anderson, Vincent A Ricigliano
The honey bee microbiota has become a hot-spot of recent research. Highly co-evolved with its host, the hindgut microbiota of a worker honey bee consists of six bacterial species shown to occur reliably in particular proportions. Altered microbiota structure is associated with host deficiencies, and a variety of bacteria found throughout the hive environment can dominate the worker gut suppressing or displacing microbiota function. The synthesis presented here suggests environmental insults alter gut bacterial balance, leading to decreased host function and disease progression...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28805436/event-related-potentials-discriminate-familiar-and-unusual-goal-outcomes-in-5-month-olds-and-adults
#4
Christine Michel, Katharina Kaduk, Áine Ní Choisdealbha, Vincent M Reid
Previous event-related potential (ERP) work has indicated that the neural processing of action sequences develops with age. Although adults and 9-month-olds use a semantic processing system, perceiving actions activates attentional processes in 7-month-olds. However, presenting a sequence of action context, action execution and action conclusion could challenge infants' developing working memory capacities. A shortened stimulus presentation of a highly familiar action, presenting only the action conclusion of an eating action, may therefore enable semantic processing in even younger infants...
August 14, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28805119/a-retrospective-audit-on-usage-of-diatrizoate-meglumine-gastrografin-%C3%A2-for-intestinal-obstruction-or-constipation-in-patients-with-advanced-neoplasms
#5
Sharon Heng, Janet Hardy, Phillip Good
BACKGROUND: Intestinal obstruction and constipation are common conditions in patients with advanced neoplasms. Diatrizoate Meglumine has been used in the management of both these conditions without good quality evidence of its effectiveness and safety. AIM: This audit aimed to assess the usage, effectiveness and adverse effects of Diatrizoate Meglumine for intestinal obstruction and constipation in patients with advanced neoplasms. DESIGN: A retrospective chart review was undertaken...
August 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28805058/energy-level-alignment-of-a-hole-transport-organic-layer-and-ito-towards-applications-for-organic-electronic-devices
#6
Quentin Arnoux, Anthony Boucly, Vincent Barth, Rabah Benbalagh, Albano Cossaro, Luca Floreano, Mathieu G Silly, Fausto Sirotti, Etienne Derat, Stephane Carniato, Fabrice Bournel, Jean-Jacques Gallet, Denis Fichou, Ludovic Tortech, Francois Rochet
2,2',6,6'-tetraphenyl-4,4'-dipyranylidene (DIPO-Ph4) was grown by vacuum-deposition on an indium tin oxide (ITO) substrate. The films were characterized by atomic force microscopy and synchrotron radiation UV and X-ray photoelectron spectroscopy to gain an insight into the material growth and to better understand the electronic properties of the DIPO-Ph4/ITO interface. Results show formation of cationic DIPO-Ph4 at ITO interface with a charge transfer from the organic layer to the anode material. This has been confronted to DFT calculations...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28804654/histoplasmosis-by-histoplasma-capsulatum-var-duboisii-observed-at-the-laboratory-of-pathological-anatomy-of-lom%C3%A3-in-togo
#7
Tchin Darré, Bayaki Saka, Abas Mouhari-Touré, Améyo Monique Dorkenoo, Koffi Amégbor, Vincent Palokinam Pitche, Gado Napo-Koura
Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1.8. The annual incidence was 1.1 cases. The mean age of the patients was 27.2 ± 0.4 years. All our patients were of social categories with a low socioeconomic level...
2017: Journal of Pathogens
https://www.readbyqxmd.com/read/28804455/comparison-of-the-long-term-effect-of-positioning-the-cathode-in-tdcs-in-tinnitus-patients
#8
Sarah Rabau, Giriraj S Shekhawat, Mohamed Aboseria, Daniel Griepp, Vincent Van Rompaey, Marom Bikson, Paul Van de Heyning
Objective: Transcranial direct current stimulation (tDCS) is one of the methods described in the literature to decrease the perceived loudness and distress caused by tinnitus. However, the main effect is not clear and the number of responders to the treatment is variable. The objective of the present study was to investigate the effect of the placement of the cathode on the outcome measurements. Methods: Patients considered for the trial were chronic non-pulsatile tinnitus patients with complaints for more than 3 months and a Tinnitus Functional Index (TFI) score that exceeded 25...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28803781/myc-regulates-chromatin-decompaction-and-nuclear-architecture-during-b-cell-activation
#9
Kyong-Rim Kieffer-Kwon, Keisuke Nimura, Suhas S P Rao, Jianliang Xu, Seolkyoung Jung, Aleksandra Pekowska, Marei Dose, Evan Stevens, Ewy Mathe, Peng Dong, Su-Chen Huang, Maria Aurelia Ricci, Laura Baranello, Ying Zheng, Francesco Tomassoni Ardori, Wolfgang Resch, Diana Stavreva, Steevenson Nelson, Michael McAndrew, Adriel Casellas, Elizabeth Finn, Charles Gregory, Brian Glenn St Hilaire, Steven M Johnson, Wendy Dubois, Maria Pia Cosma, Eric Batchelor, David Levens, Robert D Phair, Tom Misteli, Lino Tessarollo, Gordon Hager, Melike Lakadamyali, Zhe Liu, Monique Floer, Hari Shroff, Erez Lieberman Aiden, Rafael Casellas
50 years ago, Vincent Allfrey and colleagues discovered that lymphocyte activation triggers massive acetylation of chromatin. However, the molecular mechanisms driving epigenetic accessibility are still unknown. We here show that stimulated lymphocytes decondense chromatin by three differentially regulated steps. First, chromatin is repositioned away from the nuclear periphery in response to global acetylation. Second, histone nanodomain clusters decompact into mononucleosome fibers through a mechanism that requires Myc and continual energy input...
July 28, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28803548/gestational-hypertensive-disorders-and-retinal-microvasculature-the-generation-r-study
#10
Laura Benschop, Sarah Schalekamp-Timmermans, Jeanine E Roeters van Lennep, Vincent W V Jaddoe, Tien Yin Wong, Carol Y Cheung, Eric A P Steegers, Kamran M Ikram
BACKGROUND: Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy. METHODS: This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6...
August 14, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28803090/palliative-care-in-rwanda-aiming-for-universal-access
#11
Eric L Krakauer, Marie-Aimee Muhimpundu, Diane Mukasahaha, Jean-Claude Tayari, Christian Ntizimira, Blaise Uhagaze, Théodosie Mugwaneza, Aimable Ruzima, Egide Mpanumusingo, Magnus Gasana, Vincent Karamuka, Jean-Luc Nkurikiyimfura, Paul Park, Peter Barebwanuwe, Neo Tapela, Shekinah N Elmore, Gene Bukhman, Mhoira Leng, Liz Grant, Agnes Binagwaho, Richard Sezibera
In 2011, Rwanda's Ministry of Health (MoH) set a goal of universal access to palliative care by 2020. Toward this audacious egalitarian and humanitarian goal, the MoH worked with partners to develop palliative care policies and a strategic plan, secure adequate supplies of opioid for the country, initiate palliative care training programs, and begin studying a model for integrating coordinated palliative care into the public healthcare system at all levels. It also initiated training of a new cadre of home-based care practitioners (HBCPs) to provide palliative care in the home...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28803068/improved-therapeutic-efficacy-of-mammalian-expressed-recombinant-interferon-gamma-against-ovarian-cancer-cells
#12
Ali Razaghi, Carina Villacrés, Vincent Jung, Narges Mashkour, Michael Butler, Leigh Owens, Kirsten Heimann
Human interferon gamma (hIFNγ) affects tumour cells and modulates immune responses, showing promise as an anti-cancer biotherapeutic. This study investigated the effect of glycosylation and expression system of recombinant hIFNγ in ovarian carcinoma cell lines, PEO1 and SKOV3. The efficacy of E. coli- and mammalian-expressed hIFNγ (hIFNγ-CHO and HEK293, glycosylated/de-glycosylated) on cytostasis, cell death (MTT, and Guava-ViaCount(®) flow-cytometry) and apoptotic signalling (Western blot of Cdk2, histone H3, procaspase-3, FADD, cleaved PARP, and caspase-3) was examined...
August 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28802713/detecting-exact-breakpoints-of-deletions-with-diversity-in-hepatitis-b-viral-genomic-dna-from-next-generation-sequencing-data
#13
Ji-Hong Cheng, Wen-Chun Liu, Ting-Tsung Chang, Sun-Yuan Hsieh, Vincent S Tseng
Many studies have suggested that deletions of Hepatitis B Viral (HBV) are associated with the development of progressive liver diseases, even ultimately resulting in hepatocellular carcinoma (HCC). Among the methods for detecting deletions from next-generation sequencing (NGS) data, few methods considered the characteristics of virus, such as high evolution rates and high divergence among the different HBV genomes. Sequencing high divergence HBV genome sequences using the NGS technology outputs millions of reads...
August 9, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28802209/commentary-on-current-changes-of-the-soht-2016-consensus-on-alcohol-markers-in-hair-and-further-background-information
#14
Fritz Pragst, Silke Suesse, Alberto Salomone, Marco Vincenti, Vincent Cirimele, Jayne Hazon, Lolita Tsanaclis, Robert Kingston, Frank Sporkert, Markus R Baumgartner
The consensus on alcohol markers in hair was revised for the fourth time by an expert group of the Society of Hair Testing based on current state of research. This revision was adopted by the members of the Society during the business meeting in Brisbane on August 29th 2016. For both markers, ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs), two cut-off values for discrimination between teetotalers or occasional low amount consumption and moderate alcohol drinking (low cut-off), and between non-excessive (abstinence up to moderate alcohol intake) and chronic excessive drinking (high cut-off value) were critically examined...
July 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28801589/plasma-gdf15-level-is-elevated-in-psychosis-and-inversely-correlated-with-severity
#15
Parvin Kumar, Vincent Millischer, J Carlos Villaescusa, Ida A K Nilsson, Claes-Göran Östenson, Martin Schalling, Urban Ösby, Catharina Lavebratt
Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis severity was not investigated in relation to plasma GDF15 levels. In the present study we measured GDF15 levels in plasma of 120 psychosis patients compared to 120 age and gender matched healthy controls. Within the patient cohort GDF15 levels were evaluated for association with age, gender, lifestyle factors, C-reactive protein levels, psychosis severity and metabolic disorder...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801323/transvaginal-postpartum-manual-removal-of-a-prolapsed-submucous-leiomyoma-initially-diagnosed-hybrid-predominantly-intramural
#16
Wael Elgonaid, Reem Belkhir, Vincent Boama
We present a rare case of a large infarcted submucous fibroid removed manually after a normal vaginal delivery. This patient was known to have a large postero-fundal hybrid predominantly intramural uterine fibroid, measuring 11 x 10 cm in diameter and diagnosed 2 years prior to last conception. Thirty-five days postpartum, she presented with severe lower abdominal pain and foul smell per vaginum. Abdominal examination revealed a very tender bulky uterus at 24 weeks size, and vaginal examination revealed a big fleshy smelly mass with friable surface just bulging from a dilated cervix...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28801222/inferring-incomplete-lineage-sorting-duplications-transfers-and-losses-with-reconciliations
#17
Yao-Ban Chan, Vincent Ranwez, Céline Scornavacca
Gene trees and species trees can be discordant due to several processes. Standard models of reconciliations consider macro-evolutionary events at the gene level: duplications, losses and transfers of genes. However, another common source of gene tree-species tree discordance is incomplete lineage sorting (ILS), whereby gene divergences corresponding to speciations occur "out of order". However, ILS is seldom considered in reconciliation models. In this paper, we devise a unified formal IDTL reconciliation model which includes all the abovementioned processes...
August 8, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28801117/incidence-and-outcomes-of-infectious-and-noninfectious-endophthalmitis-after-intravitreal-injections-for-age-related-macular-degeneration
#18
Vincent Daien, Vuong Nguyen, Rohan W Essex, Nigel Morlet, Daniel Barthelmes, Mark C Gillies
PURPOSE: To assess the incidence, cumulative rate, and long-term outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Database study, prospectively designed. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindness! (FRB!) registry that commenced anti-VEGF therapy between January 1, 2006, and November 30, 2016...
August 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28800489/polioviruses-that-bind-a-chimeric-pvr-nectin-2-protein-identify-capsid-residues-involved-in-receptor-interaction
#19
Yi Lin, Vincent R Racaniello
Amino acid changes in the C'C"D region in poliovirus receptor domain 1 disrupt poliovirus binding. To examine further the role of the C'C"D region in poliovirus infection, we substituted this region of Pvr into the corresponding region of a murine homolog, nectin-2. The chimeric receptor, nectin-2(Pvr(c'c"d)), rendered transformed L cells susceptible to infection with poliovirus P1/Mahoney, but not with polioviruses P2/Lansing and P3/Leon, due to lack of binding. Twenty-four variants of P2/Lansing were selected that replicate in nectin-2(Pvr(c'c"d)) producing cell lines...
August 8, 2017: Virology
https://www.readbyqxmd.com/read/28800366/proceedings-of-the-isev-symposium-on-hiv-neuroaids-drug-abuse-evs
#20
Guoku Hu, Kenneth W Witwer, Vincent C Bond, Norman Haughey, Fatah Kashanchi, Lynn Pulliam, Shilpa Buch
Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30-100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell-to-cell communication and regulation...
2017: Journal of Extracellular Vesicles
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