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https://www.readbyqxmd.com/read/28449362/duration-and-exclusiveness-of-breastfeeding-and-risk-of-childhood-atopic-diseases
#1
Niels J Elbert, Evelien R van Meel, Herman T den Dekker, Nicolette W de Jong, Tamar E C Nijsten, Vincent W V Jaddoe, Johan C de Jongste, Suzanne G M A Pasmans, Liesbeth Duijts
BACKGROUND: Breastfeeding may have immune modulatory effects that influence the development of childhood allergic sensitization and atopic diseases. We aimed to examine the associations of breastfeeding with childhood allergic sensitization, inhalant or food allergy and eczema, and whether any association was affected by disease-related modification of the exposure or modified by maternal history of maternal history of allergy, eczema or asthma. METHODS: This study among 5,828 children was performed in a population-based prospective cohort from fetal life onwards...
April 27, 2017: Allergy
https://www.readbyqxmd.com/read/28449343/cost-effectiveness-of-the-highly-effective-direct-acting-antivirals-in-the-treatment-of-chronic-hepatitis-c-in-hong-kong
#2
Angeline Oi-Shan Lo, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
BACKGROUND AND AIM: In Asia-Pacific where cost is a major concern, peginterferon plus ribavirin (PR) often remain as the standard of care in chronic hepatitis C (CHC) treatment, while the direct-acting antivirals (DAAs) are commonly recommended as retreatment. Newer DAAs can achieve a sustained virological response (SVR) of nearly 100% with pan-genotypic coverage, that is "Highly Effective DAAs." We aimed to investigate the most desirable cost range for the Highly Effective DAAs using Hong Kong as an example...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28448605/vasopressor-use-following-traumatic-injury-a-single-center-retrospective-study
#3
Mathieu Hylands, Marie-Pier Godbout, Sandeep K Mayer, William D Fraser, Alain Vanasse, Marc-André Leclair, Alexis F Turgeon, François Lauzier, Emmanuel Charbonney, Vincent Trottier, Tarek S Razek, André Roy, Frédérick D'Aragon, Emilie Belley-Côté, Andrew G Day, Soazig Le Guillan, Robert Sabbagh, François Lamontagne
OBJECTIVES: Vasopressors are not recommended by current trauma guidelines, but recent reports indicate that they are commonly used. We aimed to describe the early hemodynamic management of trauma patients outside densely populated urban centers. METHODS: We conducted a single-center retrospective cohort study in a Canadian regional trauma center. All adult patients treated for traumatic injury in 2013 who died within 24 hours of admission or were transferred to the intensive care unit were included...
2017: PloS One
https://www.readbyqxmd.com/read/28448160/validation-of-anam-for-cognitive-screening-in-a-mixed-clinical-sample
#4
Andrea S Vincent, Tresa M Roebuck-Spencer, L Eugenia Cox-Fuenzalida, Cady Block, James G Scott, Robert Kane
The Automated Neuropsychological Assessment Metrics (ANAM) is a library of computer based tests designed to measure cognitive function at a single time-point or longitudinally for detection of cognitive change. This study sought to validate ANAM as a cognitive screening tool for presence of confirmed neuropsychological diagnosis in an outpatient setting. Retrospective data analysis was conducted for 139 patients referred for outpatient neuropsychological assessment. Clinical diagnosis was made independent of ANAM test results and resulted in a diagnostic mix of both neurologic and psychologic etiologies...
April 27, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28447453/a-computational-selection-of-metabolite-biomarkers-using-emerging-pattern-mining-a-case-study-in-human-hepatocellular-carcinoma
#5
Guillaume Poezevara, Sylvain Lozano, Bertrand Cuissart, Ronan Bureau, Pierre Bureau, Vincent Croixmarie, Philippe Vayer, Alban Lepailleur
The biomarker development in metabolomics aims at discriminating diseased from normal subjects and at creating a predictive model which can be used to diagnose new subjects. From a case study on human hepatocellular carcinoma (HCC), we studied for the first time the potential usefulness of the emerging patterns (EPs) which comes from the data mining domain. When applied to a metabolomics dataset labeled with two classes (e.g. HCC patients vs healthy subjects), EP mining can capture differentiating combinations of metabolites between the two classes...
April 27, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28447389/outer-membrane-vesicles-from-fibrobacter-succinogenes-s85-contain-an-array-of-carbohydrate-active-enzymes-with-versatile-polysaccharide-degrading-capacity
#6
Magnus Ø Arntzen, Anikó Várnai, Roderick I Mackie, Vincent G H Eijsink, Phillip B Pope
Fibrobacter succinogenes is an anaerobic bacterium naturally colonizing the rumen and cecum of herbivores where it utilizes an enigmatic mechanism to deconstruct cellulose into cellobiose and glucose, which serve as carbon sources for growth. Here, we illustrate that outer membrane vesicles (OMVs) released by F. succinogenes are enriched with carbohydrate-active enzymes and that intact OMVs were able to depolymerize a broad range of linear and branched hemicelluloses and pectin, despite the inability of F. succinogenes to utilize non-cellulosic (pentose) sugars for growth...
April 26, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28446959/gestational-vitamin-d-deficiency-and-autism-spectrum-disorder
#7
Anna A E Vinkhuyzen, Darryl W Eyles, Thomas H J Burne, Laura M E Blanken, Claudia J Kruithof, Frank Verhulst, Tonya White, Vincent W Jaddoe, Henning Tiemeier, John J McGrath
BACKGROUND: There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood. AIMS: To determine the association between gestational vitamin D status and ASD. METHOD: Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases)...
March 2017: BJPsych Open
https://www.readbyqxmd.com/read/28446924/differential-leukocyte-counting-via-fluorescent-detection-and-image-processing-on-a-centrifugal-microfluidic-platform
#8
Max L Balter, Alvin I Chen, C Amara Colinco, Alexander Gorshkov, Brian Bixon, Vincent Martin, Alexander Fromholtz, Timothy J Maguire, Martin L Yarmush
Centrifugal microfluidics has received much attention in the last decade for the automation of blood testing at the point-of-care, specifically for the detection of chemistries, proteins, and nucleic acids. However, the detection of common blood cells on-disc, particularly leukocytes, remains a challenge. In this paper, we present two analytical methods for enumerating leukocytes on a centrifugal platform using a custom-built fluorescent microscope, acridine orange nuclear staining, and image processing techniques...
December 21, 2016: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/28446815/terminating-the-replication-helicase
#9
Vincent Gaggioli, Philip Zegerman
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.
April 27, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28446434/donor-engrafted-chip-is-common-among-stem-cell-transplant-recipients-with-unexplained-cytopenias
#10
Christopher J Gibson, James A Kennedy, Sarah Nikiforow, Frank C Kuo, Edwin P Alyea, Vincent Ho, Jerome Ritz, Robert Soiffer, Joseph H Antin, R Coleman Lindsley
No abstract text is available yet for this article.
April 26, 2017: Blood
https://www.readbyqxmd.com/read/28446336/towards-cellular-activation-of-an-artificial-metalloenzyme-development-of-an-artificial-zymogen
#11
Vincent Lebrun
Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28445990/prognostic-value-of-tumor-mutations-in-radically-treated-locally-advanced-non-small-cell-lung-cancer-patients
#12
Angela Boros, Ludovic Lacroix, Benjamin Lacas, Julien Adam, Jean-Pierre Pignon, Caroline Caramella, David Planchard, Vincent de Montpreville, Eric Deutsch, Antonin Levy, Benjamin Besse, Cécile Le Pechoux
INTRODUCTION: Chemo-radiation is standard treatment in locally advanced non-small cell lung cancers (NSCLC). The prognostic value of mutations has been poorly explored in this population. RESULTS: Clinical data were collected from 190 patients and mutational profiles were obtained in 78 of them; 58 (74%) were males, 31 (40%) current smokers, 47/31 stage IIIA/IIIB and 40 (51%) adenocarcinoma. The following mutations were identified: EGFR 12% (9/78), KRAS 15% (12/78), BRAF 5% (3/65), PI3KCA 2% (1/57), NRAS 3% (1/32), and ALK+ (FISH) 4% (2/51)...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445878/differential-allelic-expression-of-htr1b-in-suicide-victims-genetic-and-epigenetic-effect-of-the-cis-acting-variants
#13
Ali Bani-Fatemi, Aaron Howe, Clement Zai, James L Kennedy, John Vincent, John Strauss, Albert Wong, Vincenzo De Luca
OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42)...
April 27, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28445720/hsp90-is-essential-under-heat-stress-in-the-bacterium-shewanella-oneidensis
#14
Flora Ambre Honoré, Vincent Méjean, Olivier Genest
The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen for Hsp90 client proteins identified TilS, an essential protein involved in tRNA maturation. Overexpression of TilS rescued the growth defect of the hsp90 deletion strain under heat stress. In vivo, the activity and the amount of TilS were significantly reduced in the absence of Hsp90 at high temperature...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28444962/fine-scale-species-distribution-changes-in-a-mixed-oak-stand-over-two-successive-generations
#15
Laura Truffaut, Emilie Chancerel, Alexis Ducousso, Jean Luc Dupouey, Vincent Badeau, François Ehrenmann, Antoine Kremer
Large-scale tree distribution changes have received considerable attention but underlying demo-genetic mechanisms are less well documented. We used a diachronic approach to track species shifts in a mixed oak stand (Quercus petraea-Quercus robur) at a fine spatiotemporal scale. Species assignment was made using single nucleotide polymorphism (SNP) fingerprints employing clustering and parentage analysis. Mating patterns and reproductive success were assessed by parentage analysis. Plot-based inventories of soil parameters and sapling densities provided ecological and demographic information, respectively...
April 26, 2017: New Phytologist
https://www.readbyqxmd.com/read/28444868/an-ecological-approach-to-discover-new-bioactive-extracts-and-products-the-case-of-extremophile-plants
#16
Ramla Sahli, Céline Rivière, Christel Neut, Joanne Bero, Marie-Emmanuelle Sahuc, Abderrazak Smaoui, Claire Beaufay, Vincent Roumy, Thierry Hennebelle, Yves Rouillé, Joëlle Quetin-Leclercq, Karin Séron, Riadh Ksouri, Sevser Sahpaz
OBJECTIVES: Eight extremophile plants from Tunisia were screened to find natural products with benefits in human health. METHODS: These plants were collected in different areas in Tunisia. Their methanolic extracts were evaluated for their total phenolic content and for their antiradical (DPPH), antimicrobial (on 35 bacteria and one yeast), antiviral (hepatitis C virus, HCV) and cytotoxic activity (against WI38 and J774 cell lines). The most active species were subjected to a bioguided fractionation...
April 26, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28444699/design-synthesis-and-chemistry-of-bis-%C3%AF-borate-and-agostic-complexes-of-group-7-metals
#17
Koushik Saha, Rongala Ramalakshmi, Suman Gomosta, Kriti Pathak, Vincent Dorcet, Thierry Roisnel, Jean-François Halet, Sundargopal Ghosh
A series of new bis()borate and agostic complexes of group 7 metals have been synthesized and structurally characterized from various borate ligands, such as, Na[(H3B)bbza], Na[(H3B)abz] and Na[(H2B)mp2] (bbza = bis(benzothiazol-2-yl)amine, abz = 2-aminobenzothiazolyl and mp = 2-mercaptopyridyl). Photolysis of [Mn2(CO)10] with Na[(H3B)bbza] led to the formation of bis()borate complex [Mn(CO)3(μ-H)2BHNCSC6H4(NR)], 1 (R = NCSC6H4). Under similar reaction conditions, [Re2(CO)10] generated an octahedral complex [Re(CO)2(N3C2S2C12H8)2], 2...
April 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28444225/genetic-influence-on-the-sulcal-pits-on-the-origin-of-the-first-cortical-folds
#18
Yann Le Guen, Guillaume Auzias, François Leroy, Marion Noulhiane, Ghislaine Dehaene-Lambertz, Edouard Duchesnay, Jean-François Mangin, Olivier Coulon, Vincent Frouin
The influence of genes on cortical structures has been assessed through various phenotypes. The sulcal pits, which are the putative first cortical folds, have for long been assumed to be under tight genetic control, but this was never quantified. We estimated the pit depth heritability in various brain regions using the high quality and large sample size of the Human Connectome Project pedigree cohort. Analysis of additive genetic variance indicated that their heritability ranges between 0.2 and 0.5 and displays a regional genetic control with an overall symmetric pattern between hemispheres...
April 21, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28444193/quantitative-assessment-of-timing-efficiency-specificity-and-genetic-mosaicism-of-crispr-cas9-mediated-gene-editing-of-hemoglobin-beta-gene-in-rhesus-monkey-embryos
#19
Uros Midic, Pei-Hsuan Hung, Kailey A Vincent, Benjamin Goheen, Patrick G Schupp, Diane D Chen, Daniel E Bauer, Catherine A VandeVoort, Keith E Latham
Gene editing technologies offer new options for developing novel biomedical research models and for gene and stem cell based therapies. However, applications in many species demand high efficiencies, specificity, and a thorough understanding of likely editing outcomes. To date, overall efficiencies, rates of off-targeting, and degree of genetic mosaicism have not been well-characterized for most species, limiting our ability to optimize methods. As a model gene for measuring these parameters of CRISPR/Cas9 application in a primate species (rhesus monkey), we selected the β-hemoglobin gene (HBB), which also has high relevance to potential application of gene editing and stem-cell technologies for treating human disease...
April 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28444190/biological-aging-and-the-human-gut-microbiota
#20
Vincent J Maffei, Sangkyu Kim, Eugene Blanchard, Meng Luo, S Michal Jazwinski, Christopher M Taylor, David A Welsh
The human gastrointestinal microbiota plays a key homeostatic role in normal functioning of physiologic processes commonly undermined by aging. We used a previously validated 34-item frailty index (FI34) to identify changes in gut microbiota community structure associated with biological age of community-dwelling adults. Stool 16S rRNA cDNA libraries from 85 subjects ranging in age (43-79) and FI34 score (0-0.365) were deep sequenced, denoised, and clustered using DADA2. Subject biological age but not chronological age correlated with a decrease in stool microbial diversity...
April 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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