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James Scholey
The classical view of the RAS is a linear signaling pathway beginning with the conversion of angiotensinogen to ANG I by renin, an enzyme secreted by the kidney. ANG I is converted to ANG II by angiotensin converting enzyme (ACE) ANG II binds to the G-protein coupled angiotensin II receptor type 1. The RAS is a circulating system but we now know that the RAS is also locally expressed in a number of tissues, including the kidneys and the heart. ANG II exerts adverse hemodynamic and non-hemodynamic effects on renal cells...
September 2016: Journal of Hypertension
James Scholey
The classical view of the RAS is a linear signaling pathway beginning with the conversion of angiotensinogen to ANG I by renin, an enzyme secreted by the kidney. ANG I is converted to ANG II by angiotensin converting enzyme (ACE) ANG II binds to the G-protein coupled angiotensin II receptor type 1. The RAS is a circulating system but we now know that the RAS is also locally expressed in a number of tissues, including the kidneys and the heart. ANG II exerts adverse hemodynamic and non-hemodynamic effects on renal cells...
September 2016: Journal of Hypertension
D N Kachru, S Khandelwal, S K Tandon
The effect of pretreatment and simultaneous treatment with thiamine on therapeutic efficacy of calcium disodium edetate (CaNa2EDTA) in lead intoxication was investigated in rats. The animals exposed to Pb as Pb (CH3COO)2·3 H2O through drinking water (0.1%) for 8 wk were treated with either saline, thiamine-HCl (sc), CaNa2EDTA (ip), or thiamine-HCl plus CaNa2EDTA, for 3 d or thiamine-HCl for 3 d followed by thiamine, then HCl plus CaNa2EDTA for a further 3 d. The Pb exposure caused significant accumulation of Pb in liver, kideny, and brain, inhibition in the activity of blood δ-amino-levulinic acid dehydratase (δ-ALAD), and increase in levels of urinary δ-aminolevulinic acid, homovanillic acid (HVA), vanillyl mandelic acid (VMA), brain HVA and VMA...
October 1987: Biological Trace Element Research
Emad E Ghobrial, Nermine N Mahfouz, Gihan A Fathy, Amany A Elwakkad, Heba M R Sebaii
INTRODUCTION: Nitric oxide (NO) is one of the endothelium-dependent relaxing factors released by the vascular endothelium. It is decreased in chronic kidney disease. It was found that higher levels of circulating proinflammatory cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-13 are associated with mortality. The aim of our study was to evaluate the disturbance in NO in chronic kideny failure and its relationship with hypertension and inflammatory and nutritional parameters, as indirect indexes of uremic oxidative stress...
November 2013: Iranian Journal of Kidney Diseases
Hongli Pan, Fei Zhong, Sumin Pan, Xiujin Li, Feng Zhang, Kao Zhang, Huihui Chen
OBJECTIVE: To investigate the effects of canine parvovirus (CPV) non-structural protein-1 (NS1) on the cell apoptosis induced by CPV and preliminarily explore the mechanism of CPV-induced apoptosis. METHODS: First, the NS1 gene was amplified by PCR from CPV genomic DNA and subcloned into pcDNA3. 1A vector to generate NS1 eukaryotic expression vector pcDNA-NS1. To verify whether pcDNA-NS1 vector can mediate NS1 expression in eukaryotic cells, the human embryo kideny (HEK) 293FT cells were used to transiently express the recombinant NS1...
March 4, 2012: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
M V Shestakova
Diabetic nephropathy (DN)--is a leading cause of terminal renal failure in the developed countries. Kidney pathology development undergoes several stages--from preclinical structural changes in the first years of the disease to diffuse or nodular glomerulosclerosis 15-20 years after the diabetes onset. Microalbuminuria is an early marker of DN. Intensive treatment of DN at the stage of microalbuminuria leads to regress and remission of lab parameters of DN in 40 - 50% of patients after 2 years of treatment...
2012: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Chenguang Ding, Pu-xun Tian, Wujun Xue, Xiaoming Ding, Hang Yan, Xiaoming Pan, Xinshun Feng, Heli Xiang, Jun Hou, Xiaohui Tian
High doses of cyclosporin A (CsA) can not be used in the long term treatment of kidney allograft recipients primarily due to severe side effects. In the present study, we investigated the potential application of Cordyceps sinensis (CS) in the long term treatment of renal transplant patients. The renal function and survival rates of grafts and patients did not show significantly different between the control group and the treatment group. However, the incidences of complications were significantly lower in the treatment group compared with that in control group with the exception of those showing acute rejection...
2011: Frontiers in Bioscience (Elite Edition)
No abstract text is available yet for this article.
July 16, 1960: Schweizerische Medizinische Wochenschrift
A Nishikawa, T Suzuki, K Masumura, F Furukawa, M Miyauchi, H Nakamura, H Y Son, T Nohmi, M Hayashi, M Hirose
Carcinogenic compounds are classified into 2 categories, genotoxic and non-genotoxic, which are basically judged from in vitro genotoxicity data. However, it is well documented that genotoxicants do not necessarily exert in vivo carcinogenicity in rodents, partly because of a discrepancy between in vitro and in vivo mutagenicities. Recently, transgenic animal models with reporter genes such as lacI, lacZ and gpt have been developed as a tool for assessing in vivo mutagenicity as well as carcinogenicity. In this article, data using lacI transgenic mice and gpt delta mice are presented and their application is discussed...
March 2001: Journal of Experimental & Clinical Cancer Research: CR
A Zuckermann, M Ploner, M Czerny, K Uenal, T Birsan, E Wolner, G Laufer, M Grimm
No abstract text is available yet for this article.
February 2001: Journal of Heart and Lung Transplantation
A P Evan, B A Connors, J E Lingeman, P Blomgren, L R Willis
BACKGROUND: The pig kidney is similar in structure and function to the human kideny, thus making it a useful model in understanding the human kidney in health and disease. However, little is known about the branching pattern of the pig renal artery as compared with the human and other animals. METHODS: The right and left kidneys from 11 juvenile pigs were injected with either Mercox compound to form a vascular cast or contrast media to obtain a renal arteriogram...
October 1996: Anatomical Record
T Agishi, Y Sato, S Nakasato, C Matsuzawa, T Sanaka, K Ota
Dyslipidemia including hyper-LDL(low density lipoprotein) cholesterol which is very often refractory to dietary/medical treatments is known to be a risk factor of many arteriosclerotic lesions. An extracorporeal procedure of plasma adsorption, LDL adsorption, utilizing dextran sulphate as a ligand immobilized on cellulose gel beads has been clinically applied in a variety of dyslipidemic conditions as listed below. Its usefulness in secure reduction of the serum LDL level and consequent symptomatic improvements has been confirmed...
January 1996: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
D R Kahn, J H Dufek, R Hong, W L Caldwell, F J Thomas, D R Kolenda, D K Swanson, R A Struble
Heart and kideny allografts showed markedly prolonged survival in unrelated mongrel dogs following total lymphoid irradiation (TLI) and donor bone marrow without any other immunosuppression. In every animal the heart survived longer than the kidney; genetic disparity was ruled out, since the heart and kidney from the same donor were placed into one recipient. Placing the kidney allograft in the abdomen with the bone marrow given intraperitoneally doubled kidney survival over placement in the neck, but heart survival was equally prolonged in the abdomen or neck...
July 1980: Journal of Thoracic and Cardiovascular Surgery
F Cavallo, C Riccardi, M Forni, F Pericle, M C Bosco, M Giovarelli, A Soleti, G Forni
Athymic nu/nu mice are commonly employed for the heterotransplantation of solid human tumors. Leukemias, however, have consistently proved difficult to transplant and, to enhance their take, recipient nu/nu mice have been variously immunosuppressed. In this study, the natural reactivity against human malignant T lymphoblast (PF382) of splenectomized nu/nu mice (S-nu/nu), nu/nu mice splenectomized and treated with polyinosinic-polycytidylic acid (SIC-nu/nu), and nu/nu mice splenectomized, irradiated and repeatedly injected with antiasialo GM1 antiserum (SIA-nu/nu) has been correlated with the in vivo growth of subcutaneous and intravenous PF382 cell challenges...
1991: Natural Immunity and Cell Growth Regulation
J P Pennell, V Sanjana, N R Frey, R L Jamison
To explore the role of urea in the urinary concentrating mechanism, the contents of vasa recta, Henle's descending limbs and collecting ducts were sampled by micropuncture of the renal papilla before and after infusion of urea in 10 protein-depleted rats. Eight protein-depleted rats not given urea were similarly studied as a control group. After urea administration, osmolality and the concentrations of urea and nonurea solute of urine from both exposed and contralateral kideny increased significantly. The osmolality and urea concentration of fluid from the end of Henle's descending limb and vasa recta plasma and the tubule fluid-to-plasma inulin ratio in the end-descending limb all increased significantly after urea infusion...
February 1975: Journal of Clinical Investigation
R Garcia-Rinaldi, E A Lefrak, W W Defore, L Feldman, G P Noon, J A Jachimczyk, M E DeBakey
Many kidneys obtained from cadaver donors undergoing sudden cardiac arrest cannot be transplanted due to the long periods of warm ischemia from the moment of arrest to nephrectomy. A double-ballon-triple-lumen catheter for the rapid in situ preservation of cadaver kidneys has been designed. Used in combination with equipment routinely found in any hospital, it can cool human kidneys in situ to 10-15 C and maintain this temperature until nephrectomy can be performed. Kidenys preserved with this catheter have functioned after transplantation into suitable recipients...
November 1975: Annals of Surgery
O A Goncharevskaia
By microdissection method, single nephrons have been isolated from the river lamprey Lampetra fluviatilis, teleost fish Myoxocephalus scorpius (White sea), frog Rana temporaria, lizard Agama caucasica, hen Gallus domesticus and albino rat Rattus norvegicus (Wistar strain). Tubular reabsorptive capacity was measured in kidneys of lampreys and rats by the split oil droplet method. In the animals studied, each of the nephrons consists of the glomerulus, proximal, thin and distal segments. Relative length of the proximal segment does not depend on phylogenetic position of a species...
March 1976: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
G Kiradzhiev, S Khadzhirusev, S Slavov
The authors determined the mean normal values of organ homogenates and their significance in evaluating blood amount, contained in the organs. They used radioisotope method with two kers 131 J and 51Cz for determining organ hematocrit. The hematocrit values of the organ blood differed significantly from the venous hematocrit as the values of the spleen were higher, but those of liver, kideny, cerebrum, testis and skeletal muscles-lower. On the basis of these data they proposed to apply respective correction factors, checking the differences between venous and organ hematocrits, when the amount of blood in single organs, determined by hemoglobin content, was estimated...
1976: Eksperimentalna Meditsina i Morfologiia
I Paegelow, G Schönfelder, S Nitschkoff, B Flegel
Isolated vessels (aorta thoracica, a pulmonalis, a. femoralis, a. renalis) of neurogenous-interoceptive and nephrogenous hypertensive rabbits showed a changed sensitivity to several vasoactive agents. An increased reactivity to noradrenaline, histamine, and serotonin in the aorta of neurogenous hypertensive rabbits, in the a. pulmonalis of neurogenous and renal hypertensive rabbits and in the a. femoralis of renal hypertensive animals in comparison with controls could be shown. Also registered was a hyperactivity to BaCl2 and KCl...
1976: Acta Biologica et Medica Germanica
B Baggio, S Favaro, A Antonello, A Borsatti
A phospholipase A2 activating a phospholipid renin preinhibitor into a lysophospholipid renin inhibitor has been isolated from rat kideny and partially characterized.
December 30, 1976: Research in Experimental Medicine
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