Roxana Nedelcu, Alexandra Dobre, Alice Brinzea, Ionela Hulea, Razvan Andrei, Sabina Zurac, Mihaela Balaban, Mihaela Antohe, Lorena Manea, Andreea Calinescu, Anastasia Coman, Florentina Pantelimon, Adina Dobritoiu, Catalin Popescu, Raluca Popescu, Elena Balasescu, Daniela Ion, Gabriela Turcu
Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and pathogenesis of halo nevi has not been fully elucidated. There are several mechanisms through which a lymphocytic infiltrate can induce tumoral regression. In this review, we aimed to update the knowledge about Sutton nevi starting with the clinical appearance and dermoscopic features, continuing with information regarding conventional microscopy, immunohistochemistry, and the immunological mechanisms responsible for the occurrence of halo nevi...
September 9, 2021: Journal of Personalized Medicine