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Regenerative dentistry

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https://www.readbyqxmd.com/read/29320372/a-dentin-derived-hydrogel-bioink-for-3d-bioprinting-of-cell-laden-scaffolds-for-regenerative-dentistry
#1
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane M França, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz E Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
January 10, 2018: Biofabrication
https://www.readbyqxmd.com/read/29299496/effects-of-human-adipose-derived-stem-cells-and-platelet-rich-plasma-on-healing-response-of-canine-alveolar-surgical-bone-defects
#2
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternative approaches of bone tissue healing-induced therapies at clinically chair-side procedures...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29236060/the-use-of-poly-d-l-lactic-acid-pdlla-devices-for-bone-augmentation-techniques-a-systematic-review
#3
REVIEW
Marco Annunziata, Livia Nastri, Gennaro Cecoro, Luigi Guida
Poly-d,l-lactic acid (PDLLA) has been proposed in dentistry for regenerative procedures in the form of membranes, screws, and pins. The aim of this review was to evaluate the efficacy of bone augmentation techniques using PDLLA devices. A literature search was carried out by two independent and calibrated reviewers. All interventional and observational studies assessing the efficacy of bone augmentation techniques using PDLLA devices were included. Six studies were included. The relevant variability of design and methods impeded any qualitative or quantitative comparison...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29215170/synthetic-light-curable-polymeric-materials-provide-a-supportive-niche-for-dental-pulp-stem-cells
#4
Kyle H Vining, Jacob C Scherba, Alaina M Bever, Morgan R Alexander, Adam D Celiz, David J Mooney
Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstructive manner. There is a need for restorative materials that can support native functions of dental pulp stem cells (DPSCs), which are capable of regenerating dentin. A polymer microarray formed from commercially available monomers to rapidly identify materials that support DPSC adhesion is used...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29199008/photopolymerization-of-cell-laden-gelatin-methacryloyl-hydrogels-using-a-dental-curing-light-for-regenerative-dentistry
#5
Nelson Monteiro, Greeshma Thrivikraman, Avathamsa Athirasala, Anthony Tahayeri, Cristiane M França, Jack L Ferracane, Luiz E Bertassoni
Photopolymerized hydrogels, such as gelatin methacryloyl (GelMA), have desirable biological and mechanical characteristics for a range of tissue engineering applications. OBJECTIVE: This study aimed to optimize a new method to photopolymerize GelMA using a dental curing light (DL). METHODS: Lithium acylphosphinate photo-initiator (LAP, 0.05, 0.067, 0.1% w/v) was evaluated for its ability to polymerize GelMA hydrogel precursors (10% w/v) encapsulated with odontoblast-like cells (OD21)...
November 30, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29184829/platelets-and-their-pathways-in-dentistry-systematic-review
#6
REVIEW
Faizan Ahmed Khan, Prathapan Parayaruthottam, Gazanafer Roshan, Vineeth Menon, Mariyam Fidha, Anthony Kevin Fernandes
Advancing research in medicine and technology has benefitted the mankind immensely with its contribution toward an improved life quality and increased life expectancy. The inability of a human body to autoregenerate has resulted in an increased demand for newer and healthier tissues and organs. Therefore, the restoration of naturally replicated tissue components has become a subject of interest for the scientific community lately. There was felt an intense quest for promoting strategies that could restore tissue regeneration and fuel the field of regenerative medicine...
October 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#7
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29114433/scientific-basis-of-dentistry
#8
REVIEW
Yegane Guven
Technological and scientific innovations have increased exponentially over the past years in the dentistry profession. In this article, these developments are evaluated both in terms of clinical practice and their place in the educational program. The effect of the biologic and digital revolutions on dental education and daily clinical practice are also reviewed. Biomimetics, personalized dental medicine regenerative dentistry, nanotechnology, high-end simulations providing virtual reality, genomic information, and stem cell studies will gain more importance in the coming years, moving dentistry to a different dimension...
2017: Journal of Istanbul University Faculty of Dentistry
https://www.readbyqxmd.com/read/29075021/surgical-regenerative-treatment-of-peri-implantitis
#9
Mark Steven-Howe, Derek Richards
Data sourcesOvid, Medline, PubMed, Embase and Dentistry and Oral Sciences Source. Databases were searched from January 2006 to March 2016 and restricted to English, manual searches were also carried out in the relevant major journals.Study selectionTwo reviewers independently selected studies. Human prospective and retrospective observational studies with a minimum sample size of ten implants and involving at least one surgical regenerative treatment method for peri-implantitis were considered. Excluded studies included animal and in vitro studies, patients with uncontrolled systemic disease that put the implant at risk and ceramic or coated implants...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29042736/multiple-gingival-recession-coverage-treated-with-vestibular-incision-subperiosteal-tunnel-access-approach-with-or-without-platelet-rich-fibrin-a-case-series
#10
Surbhi Garg, Sachit Anand Arora, Shivjot Chhina, Padam Singh
BACKGROUND: Gingival recession involves both soft tissue and hard tissue loss. In this evolutionary era of dentistry, newer techniques have evolved for complete coverage of isolated recession defects. Since 2012, vestibular incision subperiosteal tunnel access (VISTA) technique was used with various regenerative membranes to treat multiple recession defects (MRDs). Platelet-rich fibrin (PRF) membrane, a pool of growth factors but have any added advantage to recession coverage techniques is controversial...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29031235/homeobox-genes-and-tooth-development-understanding-the-biological-pathways-and-applications-in-regenerative-dental-science
#11
REVIEW
Anand Ramanathan, Thekkeparambil Chandrabose Srijaya, Prema Sukumaran, Rosnah Binti Zain, Noor Hayaty Abu Kasim
OBJECTIVES: Homeobox genes are a group of conserved class of transcription factors that function as key regulators during the embryonic developmental processes. They act as master regulator for developmental genes, which involves coordinated actions of various auto and cross-regulatory mechanisms. In this review, we summarize the expression pattern of homeobox genes in relation to the tooth development and various signaling pathways or molecules contributing to the specific actions of these genes in the regulation of odontogenesis...
October 4, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29028549/mta-promotes-chemotaxis-and-chemokinesis-of-immune-cells-through-distinct-calcium-sensing-receptor-signaling-pathways
#12
Fengjiao Chang, Jin Man Kim, Youngnim Choi, Kyungpyo Park
Mineral trioxide aggregate (MTA) has been introduced as a choice material for regenerative dentistry. To date, the diverse biological activities of MTA, including its anti-inflammatory effects, have been extensively discussed. However, there is limited insight into the link between MTA and immune cell migration. In this study, we report the role of MTA in enhancing both chemotactic and chemokinetic immune cell migration through distinct signaling pathways. By using versatile live imaging techniques, we demonstrated that MTA-mediated CaSR activation induced diverse downstream pathways to govern cell migratory capacity...
October 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28969579/identification-and-characterization-of-intraoral-and-dermal-fibroblasts-revisited
#13
Nurul Hafizah Mohd Nor, Zurairah Berahim, Ahmad Azlina, Khairani Idah Mokhtar, Thirumulu Ponnuraj Kannan
BACKGROUND: Fibroblasts are the common cells used in clinical regenerative medicine and dentistry. These cells are known to appear heterogeneous in vivo. Previous studies have only investigated the biological properties of these cell subpopulations in vitro. Despite sharing similarity in their spindle-shaped appearance, previous literatures revealed that they play distinguished functional and biological activities in the body. OBJECTIVE: This paper highlights the similarities and differences among these cell subpopulations, particularly between intraoral fibroblasts (human periodontal ligament, gingival and oral mucosa fibroblasts) and dermal fibroblasts based on several factors including their morphology, growth and proliferation rate...
September 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28938197/a-collagen-membrane-containing-osteogenic-protein-1-facilitates-bone-regeneration-in-a-rat-mandibular-bone-defect
#14
Manami Ozaki, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Mayu Nagao, Natsuko Tanabe, Akira Nakajima, Naoto Suzuki, Masao Maeno, Seiichi Yamano, Shuichi Sato
OBJECTIVES: Osteogenic protein-1 (OP-1) has shown osteoinductive activities and is useful for clinical treatments, including bone regeneration. Regenerative procedures using a bioabsorbable collagen membrane (BCM) are well established in periodontal and implant dentistry. We evaluated the subsequent effects of the BCM in combination with OP-1 on bone regeneration in a rat mandibular circular critical-sized bone defect in vivo. DESIGN: We used 8 rats that received surgery in both sides of the mandible, and created the total 16 defects which were divided into 4 groups: Group 1; no treatment, as a control, Group 2; BCM alone, Group 3; BCM containing low dose 0...
September 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28866015/chitosan-as-biomaterial-in-drug-delivery-and-tissue-engineering
#15
REVIEW
Saad M Ahsan, Mathai Thomas, Kranthi K Reddy, Sujata Gopal Sooraparaju, Amit Asthana, Ira Bhatnagar
Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of chitin viz. chitosan has been reported for its various important pharmacological properties and its role in tissue engineering and regenerative medicine is also well documented. Chitosan based bone graft substitutes are biocompatible, biodegradable, osteoconductive, osteoinductive and structurally similar to bone, with excellent mechanical strength and cost effectiveness. Chitosan based hydrogels and wound healing bandages have also found a great market in the field of medicine...
August 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28827850/platelet-poor-plasma-as-a-supplement-for-fibroblasts-cultured-in-platelet-rich-fibrin
#16
Luiz Alexandre Chisini, Sarah Arangurem Karam, Thaís Gioda Noronha, Letícia Regina Morello Sartori, Alissa Schmidt San Martin, Flávio Fernando Demarco, Marcus Cristian Muniz Conde
The aim of this study was to evaluate the proliferation and adhesion of mesenchymal cells (3T3/NIH) in Dulbecco's Modified Eagle Medium(DMEM) supplemented with Platelet-Poor Plasma (PPP) in aPlatelet-Rich Fibrin (PRF) scaffold. Human blood was obtained and processed in a centrifuge considering the equation G=1.12xRx(RPM/1000)(2) to obtain PRF and PPP.Cell adhesion and maintenance analyses were performed by MTTassays in a 96 well plate withsupplemented DMEM: PPP (90:10) for 24 hours. Besides, the PRF was deposited in a 48 well plate and 10x10(4) cells were seeded above each PRF (n=3) with 800µl of DMEM: PPP (90:10) and cultured for 7 days...
June 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28727999/drug-ion-co-delivery-multi-functional-nanocarrier-to-regenerate-infected-tissue-defect
#17
Jung-Hwan Lee, Ahmed El-Fiqi, Nandin Mandakhbayar, Hae-Hyoung Lee, Hae-Won Kim
Regeneration of infected tissues is a globally challenging issue in medicine and dentistry. Common clinical therapies involving a complete removal of infected areas together with a treatment of antimicrobial drugs are often suboptimal. Biomaterials with anti-bacterial and pro-regenerative potential can offer a solution to this. Here we design a novel nanocarrier based on a mesoporous silicate-calcium glass by doping with Ag ions and simultaneously loading antimicrobial drugs onto mesopores. The nanocarriers could controllably release multiple ions (silver, calcium, and silicate) and drugs (tetracycline or chlorohexidine) to levels therapeutically relevant, and effectively internalize to human dental stem cells (∼90%) with excellent viability, ultimately stimulating odontogenic differentiation...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28589921/current-and-emerging-applications-of-3d-printing-in-medicine
#18
Chya-Yan Liaw, Murat Guvendiren
Three-dimensional (3D) printing enables the production of anatomically matched and patient-specific devices and constructs with high tunability and complexity. It also allows on-demand fabrication with high productivity in a cost-effective manner. As a result, 3D printing has become a leading manufacturing technique in healthcare and medicine for a wide range of applications including dentistry, tissue engineering and regenerative medicine, engineered tissue models, medical devices, anatomical models and drug formulation...
June 7, 2017: Biofabrication
https://www.readbyqxmd.com/read/28575964/scaffolds-for-bone-tissue-engineering-state-of-the-art-and-new-perspectives
#19
REVIEW
Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isabella Bartolotti, Brunella Grigolo
This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28551729/use-of-platelet-rich-fibrin-in-regenerative-dentistry-a-systematic-review
#20
REVIEW
Richard J Miron, Giovanni Zucchelli, Michael A Pikos, Maurice Salama, Samuel Lee, Vincent Guillemette, Masako Fujioka-Kobayashi, Mark Bishara, Yufeng Zhang, Hom-Lay Wang, Fatiha Chandad, Cleopatra Nacopoulos, Alain Simonpieri, Alexandre Amir Aalam, Pietro Felice, Gilberto Sammartino, Shahram Ghanaati, Maria A Hernandez, Joseph Choukroun
OBJECTIVES: Research across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation. MATERIALS AND METHODS: Manuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures...
July 2017: Clinical Oral Investigations
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