keyword
MENU ▼
Read by QxMD icon Read
search

carbonylated proteins

keyword
https://www.readbyqxmd.com/read/28229142/olive-leaf-extract-concentrated-in-hydroxytyrosol-attenuates-protein-carbonylation-and-the-formation-of-advanced-glycation-end-products-in-a-hepatic-cell-line-hepg2
#1
Marta Navarro, Francisco J Morales, Sonia Ramos
Glycation takes place both at the cellular level and at the extracellular matrix level and generates, consequently, advanced glycation end-products (AGEs) associated with chronic diseases and the aging process. Two olive leaf extracts concentrated in (i) oleuropein (OLE-A; 93.9 mg oleuropein g(-1)) and (ii) hydroxytyrosol (OLE-B; 54.5 mg hydroxytyrosol g(-1)) were evaluated according to their antiglycative and antioxidant capacity in vitro. OLE-B exerted the highest anti-AGE effect in different glycation models (IC50: 0...
February 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28224432/effect-of-triptolide-on-expression-of-oxidative-carbonyl-protein-in-renal-cortex-of-rats-with-diabetic-nephropathy
#2
Xing-Gang Dong, Zeng-Mei An, Yuan Guo, Jia-Liang Zhou, Tao Qin
The traditional Chinese medicine (Tripterygium wilfordiiHook.f., TWH) has been clinically used to treat primary and secondary renal diseases and proteinuria for nearly 40 years. However, there is a rare literature about the effect of triptolide (the main active ingredient of TWH) on the expression of oxidative carbonyl protein (OCP) in diabetic nephropathy (DN). This study aimed to provide experimental evidence for triptolide treatment on DN through its effect on the expression of OCP, in order to investigate the effects of triptolide on the expression of OCP in rats with DN...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28223068/parasite-control-and-skeletal-myositis-in-trypanosoma-cruzi-infected-and-exercised-rats
#3
Rômulo D Novaes, Reggiani V Gonçalves, Arlete R Penitente, Marli C Cupertino, Izabel R S C Maldonado, André Talvani, Antônio J Natali
Non-pharmacological strategies have been rarely described in the treatment of infectious diseases. Although exercise training has been recently incorporated in the clinical management of Chagas disease, the rationale basis that supports this indication is poorly understood. Thus, we investigated the effect of an aerobic exercise on the parasitism, inflammation and oxidative tissue damage in a murine model of Trypanosoma cruzi-induced skeletal myositis. Wistar rats were randomized into four groups: trained not infected (TNI) and infected (TI), sedentary not infected (SNI) and infected (SI)...
February 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28222349/aldo-keto-reductase-1-akr1-protect-cellular-enzymes-from-salt-stress-by-detoxifying-reactive-cytotoxic-compounds
#4
Ramu S Vemanna, K C Babitha, Jayant K Solanki, V Amarnatha Reddy, S K Sarangi, M Udayakumar
Cytotoxic compounds like reactive carbonyl compounds such as methylglyoxal (MG), melandialdehyde (MDA), besides the ROS accumulate significantly at higher levels under salinity stress conditions and affect lipids and proteins that inhibit plant growth and productivity. The detoxification of these cytotoxic compounds by overexpression of NADPH-dependent Aldo-ketoreductase (AKR1) enzyme enhances the salinity stress tolerance in tobacco. The PsAKR1 overexpression plants showed higher survival and chlorophyll content and reduced MDA, H2O2, and MG levels under NaCl stress...
February 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28220339/triphenyltin-hydroxide-induces-changes-in-the-oxidative-stress-parameters-of-fish
#5
Bárbara Clasen, Alexssandro G Becker, Thais Lópes, Camila R Murussi, Fabiane G Antes, Roberta C Horn, Érico M M Flores, Bernardo Baldisserotto, Valderi L Dressler, Vania L Loro
Among all organotin compounds , triphenyltin hydroxide (TPhTH) is widely used as fungicide and moluscicide in Brazil. However, the effects of TPhTH on the biochemical parameters of non-target organisms, such as fish, are little known. The aim of the present study is to assess the possible toxic effects of different concentrations of waterborne TPhTH on silver catfish belonging to species Rhamdia quelen. The fish were exposed to two different concentrations of TPhTH (1.08 and 1.70 µg/L as Sn) for 15 days and then compared to the control group (triplicate, n = 3)...
February 20, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28220152/lack-of-mycothiol-and-ergothioneine-induces-different-protective-mechanisms-in-mycobacterium-smegmatis
#6
Arishma Rajkarnikar Singh, Andrew Strankman, Ruzan Orkusyan, Endang Purwantini, Mamta Rawat
Mycobacterium smegmatis contains the low molecular weight thiols, mycothiol (MSH) and ergothioneine (ESH). Examination of transposon mutants disrupted in mshC and egtA, involved in the biosynthesis of MSH and ESH respectively, demonstrated that both mutants were sensitive to oxidative, alkylating, and metal stress. However, the mshC mutant exhibited significantly more protein carbonylation and lipid peroxidation than wildtype, while the egtA mutant had less protein and lipid damage than wildtype. We further show that Ohr, KatN, and AhpC, involved in protection against oxidative stress, are upregulated in the egtA mutant...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28219781/adenosine-a2-receptor-activation-ameliorates-mitochondrial-oxidative-stress-upon-reperfusion-through-the-posttranslational-modification-of-ndufv2-subunit-of-complex-i-in-the-heart
#7
Jingman Xu, Xiyun Bian, Yuan Liu, Lan Hong, Tianming Teng, Yuemin Sun, Zhelong Xu
While it is well known that adenosine receptor activation protects the heart from ischemia/reperfusion injury, the precise mitochondrial mechanism responsible for the action remains unknown. This study probed the mitochondrial events associated with the cardioprotective effect of 5'-(N-ethylcarboxamido) adenosine (NECA), an adenosine A2 receptor agonist. Isolated rat hearts were subjected to 30min ischemia followed by 10min of reperfusion, whereas H9c2 cells experienced 20min ischemia and 10min reperfusion...
February 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28212704/neurochemical-differences-in-learning-and-memory-paradigms-among-rats-supplemented-with-anthocyanin-rich-blueberry-diets-and-exposed-to-acute-doses-of-56-fe-particles
#8
Shibu M Poulose, Bernard M Rabin, Donna F Bielinski, Megan E Kelly, Marshall G Miller, Nopporn Thanthaeng, Barbara Shukitt-Hale
The protective effects of anthocyanin-rich blueberries (BB) on brain health are well documented and are particularly important under conditions of high oxidative stress, which can lead to "accelerated aging." One such scenario is exposure to space radiation, consisting of high-energy and -charge particles (HZE), which are known to cause cognitive dysfunction and deleterious neurochemical alterations. We recently tested the behavioral and neurochemical effects of acute exposure to HZE particles such as (56)Fe, within 24-48h after exposure, and found that radiation primarily affects memory and not learning...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28212432/genetically-encoded-ratiometric-fluorescent-thermometer-with-wide-range-and-rapid-response
#9
Masahiro Nakano, Yoshiyuki Arai, Ippei Kotera, Kohki Okabe, Yasuhiro Kamei, Takeharu Nagai
Temperature is a fundamental physical parameter that plays an important role in biological reactions and events. Although thermometers developed previously have been used to investigate several important phenomena, such as heterogeneous temperature distribution in a single living cell and heat generation in mitochondria, the development of a thermometer with a sensitivity over a wide temperature range and rapid response is still desired to quantify temperature change in not only homeotherms but also poikilotherms from the cellular level to in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#10
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28209096/increased-oxidative-stress-alters-nucleosides-metabolite-levels-in-sickle-cell-anemia
#11
Lívia Gelain Castilhos, Juliana Sorraila de Oliveira, Stephen Adeniyi Adefegha, Luana Pereira Magni, Pedro Henrique Doleski, Fatima Husein Abdalla, Cínthia Melazzo de Andrade, Daniela Bitencourt Rosa Leal
OBJECTIVES: This study was conducted to assess the markers of oxidative stress, myeloperoxidase (MPO), acetylcholinesterase (AChE) and xanthine oxidase (XO) activities as well as the levels of nucleotide metabolites in sickle cell anemia (SCA) patients. METHODS: Fifteen SCA treated patients and 30 health subjects (control group) were selected. The markers of oxidative stress (levels of reactive oxygen species (ROS), plasma proteins, carbonyl content, lipid peroxidation (TBARS), total thiols (T-SH), glutathione and catalase activity), MPO, AChE and XO activities as well as the levels of nucleotide metabolites were measured in SCA patients...
February 16, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28207997/chronically-elevated-bilirubin-protects-from-cardiac-reperfusion-injury-in-the-male-gunn-rat
#12
Bhavisha Bakrania, Eugene F Du Toit, Kevin J Ashton, Karl-Heinz Wagner, John P Headrick, Andrew C Bulmer
AIMS: Bilirubin is associated with reduced risk of cardiovascular disease, as evidenced in conditions of mild hyperbilirubinaemia (Gilbert's Syndrome). Little is known regarding myocardial stress-resistance in hyperbilirubinemic conditions or whether life-long exposure modifies cardiac function, which might contribute to protection from cardiovascular disease. METHODS: Hyperbilirubinemic rats and littermate controls underwent echocardiography at 3, 6 and 12 mo of age, with hearts subsequently assessed for resistance to 30 min of ischaemia...
February 16, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28207414/anti-aging-effects-of-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-immunosuppressive-drug-on-the-enzymatic-and-non-enzymatic-oxidative-stress-parameters-in-an-experimental-model
#13
Soma Hosseini, Mohammad Abdollahi, Gholamreza Azizi, Mohammad Javad Fattahi, Noshin Rastkari, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Abbas Mirshafiey
BACKGROUND: The anti-aging property of β-D-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory and immunosuppressive agent was investigated on several determinants relative to the oxidative stress in an animal model. MATERIALS AND METHODS: Sprague-Dawley rats were used for evaluating the safety and efficacy properties of M2000 on some oxidative stress enzymes, including the following: mitochondrial superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX1), glutathione S-transferase (GST), myeloperoxidase (MPO), and inducible nitric oxide synthase (iNOS) gene expression by real-time PCR...
February 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28207024/-ru-co-x-core-complexes-with-benzimidazole-ligands-synthesis-x-ray-structure-and-evaluation-of-anticancer-activity-in-vivo
#14
Gabriella Tamasi, Antonello Merlino, Federica Scaletti, Petra Heffeter, Anton A Legin, Michael A Jakupec, Walter Berger, Luigi Messori, Bernhard K Keppler, Renzo Cini
The reaction of [Ru(CO)6Cl2], 1, with N[combining low line](3)-methylbenzimidazole (MBI) and 5,6-dimethylbenzimidazole (DMBI) afforded two new complexes with the general formula fac-[Ru(II)(CO)3Cl2L], L = MBI (2) or DMBI (4). Crystals of cis,trans-[Ru(II)(CO)2Cl2(N[combining low line](3)-MBI)2], 3, were also obtained from the mother liquor that produced 2. In the presence of water, the dissociation of Ru-N, Ru-Cl and Ru-CO bonds occurred as a function of time, water content and pH. Density functional theory structure simulations/optimizations were carried out at the Becke3LYP level of theory for evaluating the relative stability of possible conformers...
February 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28205623/preventive-effects-of-carnosine-on-lipopolysaccharide-induced-lung-injury
#15
Ken-Ichiro Tanaka, Toshifumi Sugizaki, Yuki Kanda, Fumiya Tamura, Tomomi Niino, Masahiro Kawahara
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Carnosine (β-alanyl-L-histidine) is a small di-peptide with numerous activities, including antioxidant effects, metal chelation, proton buffering capacity and the inhibition of protein carbonylation and glycoxidation...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202649/antioxidants-and-embryo-phenotype-is-there-experimental-evidence-for-strong-integration-of-the-antioxidant-system
#16
Cristina Daniela Possenti, Filiz Karadas, Graziano Colombo, Manuela Caprioli, Diego Rubolini, Aldo Milzani, Isabella Dalle Donne, Nicola Saino, Marco Parolini
Organisms have evolved complex defense systems against oxidative stress. Bird eggs contain maternally derived antioxidants that protect embryos from oxidative damage. The antioxidant system components are thought to be integrated, but few studies have analyzed the covariation between antioxidant concentrations, embryo 'oxidative status' and morphology. In addition, no study has tested the effects of experimental change in yolk antioxidant concentration on other antioxidants, on their reciprocal relationships and on their relationships with embryo oxidative status or growth, which are expected if antioxidants defenses are integrated...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28202648/living-in-flowing-water-increases-resistance-to-ultraviolet-b-radiation
#17
Ensiyeh Ghanizadeh-Kazerouni, Craig E Franklin, Frank Seebacher
Ultraviolet B radiation (UV-B) is an important environmental driver that can affect locomotor performance negatively by inducing production of reactive oxygen species (ROS). Prolonged regular exercise increases antioxidant activities, which may alleviate the negative effects of UV-B-induced ROS. Animals naturally performing exercise, such as humans performing regular exercise or fish living in flowing water, may therefore be more resilient to the negative effects of UV-B. We tested this hypothesis in a fully factorial experiment, where we exposed mosquitofish (Gambusia holbrooki) to UV-B and control (no UV-B) conditions in flowing and still water...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28199417/physical-activity-prevents-alterations-in-mitochondrial-ultrastructure-and-glucometabolic-parameters-in-a-high-sugar-diet-model
#18
Karina Barbosa de Queiroz, Kinulpe Honorato-Sampaio, Joamyr Victor Rossoni Júnior, Diego Andrade Leal, Angélica Barbosa G Pinto, Lenice Kappes-Becker, Elisio Alberto Evangelista, Renata Guerra-Sá
Endurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD). Weaned male Wistar rats fed with a standard diet or a HSD (68% carbohydrate) were subjected to 60 minutes of regular physical activity by swimming (without workload) for four- (20 sessions) or eight-week (40 sessions) periods...
2017: PloS One
https://www.readbyqxmd.com/read/28198206/nitraria-retusa-fruit-prevents-penconazole-induced-kidney-injury-in-adult-rats-through-modulation-of-oxidative-stress-and-histopathological-changes
#19
Mariem Chaâbane, Mohamed Koubaa, Nejla Soudani, Awatef Elwej, Malek Grati, Kamel Jamoussi, Tahia Boudawara, Semia Ellouze Chaabouni, Najiba Zeghal
CONTEXT: Nitraria retusa (Forssk.) Asch. (Nitrariaceae) is a medicinal plant which produces edible fruits whose antioxidant activity has been demonstrated. OBJECTIVE: The current study elucidates the potential protective effect of N. retusa fruit aqueous extract against nephrotoxicity induced by penconazole, a triazole fungicide, in the kidney of adult rats. MATERIALS AND METHODS: Adult Wistar rats were exposed either to penconazole (67 mg/kg body weight), or to N...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28196659/sutures-impregnated-with-carbazate-activated-polyvinyl-alcohol-reduce-intraperitoneal-adhesions
#20
F Fredriksson, F Sellberg, T Bowden, T Engstrand, D Berglund, H E Lilja
BACKGROUND: Intraperitoneal adhesions cause significant morbidity. They occur after peritoneal trauma, which induces oxidative stress with production of inflammatory cytokines, peroxidized proteins (carbonyls) and lipids (aldehydes). This study aimed to investigate if carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl inhibitor, can reduce intraperitoneal adhesions in an experimental model. MATERIAL AND METHODS: Male Sprague-Dawley rats (n=110) underwent laparotomy, cecal abrasion and construction of a small bowel anastomosis...
February 1, 2017: Journal of Pediatric Surgery
keyword
keyword
36460
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"