keyword
https://read.qxmd.com/read/38365778/cannabis-use-decision-making-and-perceptions-of-risk-among-breastfeeding-individuals-the-lactation-and-cannabis-lac-study
#21
JOURNAL ARTICLE
Caroline B Smith, Jenna Schmidt, Elizabeth A Holdsworth, Beatrice Caffé, Olivia Brooks, Janet E Williams, David R Gang, Mark A McGuire, Michelle K McGuire, Celestina Barbosa-Leiker, Courtney L Meehan
OBJECTIVE: Our primary objective was to understand breastfeeding individuals' decisions to use cannabis. Specifically, we investigated reasons for cannabis use, experiences with healthcare providers regarding use, and potential concerns about cannabis use. METHODS: We collected survey data from twenty breastfeeding participants from Washington and Oregon who used cannabis at least once weekly. We documented individuals' cannabis use and analyzed factors associated with their decisions to use cannabis during lactation...
February 16, 2024: Journal of cannabis research
https://read.qxmd.com/read/38352661/cannabidiol-derived-cannabinoids-the-unregulated-designer-drug-market-following-the-2018-farm-bill
#22
REVIEW
Charles N Zawatsky, Sara Mills-Huffnagle, Corinne M Augusto, Kent E Vrana, Jennifer E Nyland
BACKGROUND: In this review, we summarize current scientific knowledge on psychoactive cannabinoids synthesized from cannabidiol (CBD) and sold in the semi-legal market established in response to the passage of the US Agriculture Improvement Act of 2018, commonly known as the 2018 Farm Bill. The discussion focuses on recent developments that suggest this unregulated market may be fertile ground for a potential health crisis. SUMMARY: Current research into CBD-derived cannabinoids is mainly limited to Δ8 -tetrahydrocannabinol (Δ8 -THC) products, with some recent publications beginning to explore O-acetyl-THC, a term describing the acetate ester of Δ8 -THC or Δ9 -THC, and its potential pulmonary toxicity...
2024: Medical cannabis and cannabinoids
https://read.qxmd.com/read/38343069/simultaneous-cannabis-and-alcohol-use-among-medical-cannabis-patients
#23
JOURNAL ARTICLE
Alexandra F Kritikos, Julie K Johnson, Dominic Hodgkin
Background: During the past two decades of cannabis legalization, the prevalence of medical cannabis (MC) use has increased and there has also been an upward trend in alcohol consumption. As less restricted cannabis laws generate more adult cannabis users, there is concern that more individuals may be simultaneously using medical cannabis with alcohol. A few studies have examined simultaneous use of medical cannabis with alcohol, but none of those studies also assessed patients' current or previous non-medical cannabis use...
February 11, 2024: Substance Use & Misuse
https://read.qxmd.com/read/38319080/how-much-thc-is-in-that-joint-a-daily-diary-study-of-young-adults-knowledge-of-the-cannabinoid-content-of-cannabis-products
#24
JOURNAL ARTICLE
Sophie G Coelho, Christian S Hendershot, Nicolle Fox, Jeffrey D Wardell
OBJECTIVE: Many young adults report frequent cannabis use and are at risk for cannabis harms. Knowledge of the tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations of cannabis products may promote harm reduction, but few studies have characterized cannabinoid concentration knowledge in this population. This study used day-level data to examine predictors of cannabinoid concentration knowledge and associations of cannabinoid concentration knowledge with substance-related consequences among young adults...
February 6, 2024: Journal of Studies on Alcohol and Drugs
https://read.qxmd.com/read/38313688/recurrent-cannabis-induced-catatonia-a-case-report-and-comprehensive-systematic-literature-review
#25
Reza Moshfeghinia, Mehrnaz Hosseinzadeh, Sara Mostafavi, Roxana Jabbarinejad, Mahdi Malekpour, Elnaz Chohedri, Jamshid Ahmadi
BACKGROUND: Catatonia presents itself as a complex neuropsychiatric syndrome, giving rise to various motor, speech, and behavioral challenges. It is noteworthy that approximately 10% of psychiatric hospital admissions can be attributed to this condition. It is imperative to note that cannabis-induced catatonia, while infrequent, has been linked to the use of marijuana. This connection has the potential to disrupt neurotransmitter systems, necessitating further research for a comprehensive understanding and effective treatment, particularly given the evolving trends in cannabis use...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38294845/comparison-between-smoked-tobacco-and-medical-cannabis-cigarettes-concerning-particulate-matter
#26
JOURNAL ARTICLE
Fenna Janssen, Markus Braun, Janis Dröge, Dörthe Brüggmann, David A Groneberg
Introduction: Cannabis is a widely used drug like tobacco and alcohol. In the meantime, it is also prescribed for medical treatment in some countries. Tobacco smoke contains chemical carcinogens and particulate matter (PM) that are both harmful to health. Method: In this study, we investigated PM levels in second-hand smoke (SHS) of hand-tamped cannabis cigarettes compared to cigarettes with tubing tobacco and the 3R4F reference cigarette. Results: It could be demonstrated that the largest proportion of the particle mass is attributable to particles with a diameter of less than 1μm and that every tested cigarette emitted more PM than the 3R4F reference cigarette...
January 31, 2024: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/38292071/pharmacokinetic-variability-of-oral-cannabidiol-and-its-major-metabolites-after-short-term-high-dose-exposure-in-healthy-subjects
#27
JOURNAL ARTICLE
Qingchen Zhang, Philip W Melchert, John S Markowitz
INTRODUCTION: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as a prescriptive drug treatment and over-the-counter supplement. In humans, CBD is metabolized and forms the major active metabolite 7-hydroxy-cannabidiol (7-OH-CBD), which is further metabolized to 7-carboxy-cannabidiol (7-COOH-CBD). In the current study, plasma concentrations of CBD, 7-OH-CBD, and 7-COOH-CBD were measured, and the potential influences of sex, race, and body mass index (BMI) on the pharmacokinetic variability were assessed...
2024: Medical cannabis and cannabinoids
https://read.qxmd.com/read/38289872/introducing-and-studying-the-materials-and-methods-of-anesthesia-and-analgesia-in-ancient-iran
#28
JOURNAL ARTICLE
Masoumeh Dehghan, Mohammad Hashemimehr, Mahboobeh Farkhondehzadeh
In ancient Iran, humans have been looking for ways to anesthetize, control, and reduce pain to perform surgeries to treat diseases, which is evident in ancient scientists' medical and nonmedical works. Although modern anesthesia expanded with the introduction of ether into this process, this great success was achieved after years of suffering and with the efforts of scientists throughout history who have played an essential role in advancing this knowledge. In ancient Iran, may (wine) was one of the materials of anesthesia, as in the Avesta, and Minooye Kherad, the properties of wine as an anesthetic are mentioned...
January 30, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38280073/predictors-of-adequate-pain-control-after-outpatient-hand-and-upper-extremity-surgery
#29
JOURNAL ARTICLE
Colin Swigler, Keegan M Hones, Joseph J King, Thomas W Wright, Aimee M Struk, Robert C Matthias
PURPOSE: The opioid epidemic has changed practice, though there remains a paucity of data regarding prescribing habits and pain control following outpatient hand surgery. We sought to evaluate patient-related predictors of adequate postoperative pain control. METHODS: A retrospective review was performed of a single-center prospectively collected database of elective outpatient surgery on the elbow, forearm, wrist, and/or hand. Patients were asked to complete preoperative and postoperative questionnaires to capture their perception of anticipated pain levels, expected prescription quantity/duration, additional medications used, and overall pain satisfaction...
January 27, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38278190/experience-with-medical-marijuana-in-a-pediatric-palliative-care-clinic-case-report
#30
JOURNAL ARTICLE
Jenna Sahli, Daniel Grossoehme, Sarah Friebert
Children receiving palliative care have life-limiting or life-threatening conditions, which include symptoms ranging from unpleasant to intolerable suffering. We describe three diverse cases of medical marijuana within ambulatory pediatric palliative care, highlighting use for spasticity, refractory seizures, and cancer-related symptoms. Included are caregiver perspectives of their child's experience with medical marijuana. This population has high potential for positive effects from medical marijuana therapy, particularly for maximizing quality of life...
January 24, 2024: Journal of Pain and Symptom Management
https://read.qxmd.com/read/38277855/risk-of-motor-vehicle-collision-associated-with-cannabis-and-alcohol-use-among-patients-presenting-for-emergency-care
#31
JOURNAL ARTICLE
Esther K Choo, Stacy A Trent, Daniel K Nishijima, Angela Eichelberger, Steve Kazmierczak, Yu Ye, Karen J Brasel, Ariane Audett, Cheryl J Cherpitel
BACKGROUND: The objective of this study was to examine the relationship between cannabis and alcohol use and occurrence of motor vehicle collision (MVC) among patients in the emergency department (ED). METHODS: This was a cross-sectional study of visits to EDs in Denver, CO, Portland, OR, and Sacramento, CA by drivers who were involved in MVCs and presented with injuries (cases) and non-injured drivers (controls) who presented for medical care. We obtained blood samples and measured delta-9-THC and its metabolites...
January 24, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38266723/phthalate-exposure-increases-interferon-%C3%AE-during-pregnancy-the-atlanta-african-american-maternal-child-cohort
#32
JOURNAL ARTICLE
Kaitlin R Taibl, Anne L Dunlop, Dana Boyd Barr, P Barry Ryan, Parinya Panuwet, Elizabeth J Corwin, Jasmin A Eatman, Youran Tan, Donghai Liang, Stephanie M Eick
BACKGROUND: The immune system undergoes unique adaptations during pregnancy and is particularly sensitive to environmental chemicals, such as phthalates, which are associated with acute and chronic inflammatory medical conditions. However, current knowledge of how phthalate exposures are associated with systemic inflammation in pregnant people is limited by cross-sectional study designs and single chemical models. Our objective was to estimate the association between repeated measures of prenatal phthalate exposures, examined individually and collectively, and a panel of clinical inflammatory biomarkers...
January 22, 2024: Science of the Total Environment
https://read.qxmd.com/read/38258856/an-assessment-of-the-one-month-effectiveness-of-telehealth-treatment-for-opioid-use-disorder-using-the-brief-addiction-monitor
#33
JOURNAL ARTICLE
Barbara Burke, Brian Clear, Rebekah L Rollston, Emily N Miller, Scott G Weiner
OBJECTIVES: Telehealth treatment with medication for opioid use disorder (teleMOUD) was made possible with regulations following the COVID-19 pandemic that permitted prescribing buprenorphine without an in-person visit. This study evaluates the self-reported outcomes of patients treated by teleMOUD using the Brief Addiction Monitor (BAM), a 17-question tool that assesses drug use, cravings, physical and psychological health, and psychosocial factors to produce 3 subset scores: substance use, risk factors, and protective factors...
January 2024: Subst Use Addctn J
https://read.qxmd.com/read/38252547/acute-and-extended-anxiolytic-effects-of-cannabidiol-in-cannabis-flower-a-quasi-experimental-ad-libitum-use-study
#34
JOURNAL ARTICLE
L Cinnamon Bidwell, Renée Martin-Willett, Carillon Skrzynski, Jonathon Lisano, Marco Ortiz Torres, Gregory Giordano, Kent E Hutchison, Angela D Bryan
Objective: Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have varying pharmacological actions with differential effects on acute and extended affective states, incuding anxiety. We aimed to study these effects on anxiety in legal market forms of cannabis. Method: This study makes use of a nonequivalent control group quasiexperimental design. Forty-two participants with anxiety symptions who were not using cannabis were compared to 258 participants with anxiety symptoms who used cannabis flower (∼3-4 times per week)...
January 22, 2024: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/38249204/cannabis-associated-pneumothorax-a-case-report
#35
Dennis N Mensah, Jonathan Livingston, Vasudha Maddukuri
The use of cannabis for therapeutic and recreational purposes has been on the rise in recent years. This has increased the prevalence of cannabis use disorder across various demographic subgroups. A recent medical literature review describes a few cases demonstrating the association of spontaneous pneumothorax and bullous lung disease in cannabis users without concomitant tobacco use. We herein present a case report of a young male with chronic cannabis use who presented with right-sided spontaneous pneumothorax and bilateral apical blebs...
December 2023: Curēus
https://read.qxmd.com/read/38236449/current-cannabis-use-and-pain-management-among-us-cancer-patients
#36
JOURNAL ARTICLE
Jessica L Krok-Schoen, Jesse J Plascak, Alison M Newton, Scott A Strassels, Anita Adib, Neema C Adley, John L Hays, Theodore L Wagener, Erin E Stevens, Theodore M Brasky
BACKGROUND: National studies reporting the prevalence of cannabis use have focused on individuals with a history of cancer without distinction by their treatment status, which can impact symptom burden. While pain is a primary motivation to use cannabis in cancer, the magnitude of its association with cannabis use remains understudied. METHODS: We examined cannabis use and pain management among 5523 respondents of the Behavioral Risk Factor Surveillance System with a cancer history...
January 18, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38228057/associations-between-cannabis-use-opioid-misuse-and-severe-psychological-distress-in-adolescents-a-cross-sectional-school-based-study-cannabis-opioids-and-mental-health
#37
JOURNAL ARTICLE
Hugues Sampasa-Kanyinga, Jean-Philippe Chaput, Fatima Mougharbel, Hayley A Hamilton
BACKGROUND: Cannabis use and nonmedical use of prescription opioids are consumed by a small to moderate number of adolescents. However, little is known about their combined influence on mental health in this age group. This study examined the association between cannabis use, nonmedical use of prescription opioids, or both with serious psychological distress among adolescents and tested if sex could moderate these associations. METHODS: We based our analyses on cross-sectional data from the 2019 Ontario Student Drug Use and Health Survey, a provincially representative sample of students in grades 7 through 12 (aged 11-20 years or older) across Ontario, Canada (n= 7097; mean age: 15...
January 6, 2024: Drug and Alcohol Dependence
https://read.qxmd.com/read/38226097/the-therapeutic-potential-of-cannabidiol-in-revolutionising-opioid-use-disorder-management
#38
REVIEW
Kelvin Le, Joanne Au, Jean Hua, Khang Duy Ricky Le
Opioid use disorder (OUD) is a significant cause of morbidity and mortality worldwide and is linked to a complex interplay of biopsychosocial factors as well as the increasing overprescription and availability of opioid medications. Current OUD management relies on the controlled provision of opioid medications, such as methadone or buprenorphine, known as opioid replacement therapy. There is variable evidence regarding the long-term efficacy of these medications in improving the management of OUD, thereby necessitating an exploration into innovative approaches to complement, or even take the place of, existing treatment paradigms...
December 2023: Curēus
https://read.qxmd.com/read/38216357/evaluation-of-pre-hospital-cannabis-exposure-and-hospital-opioid-utilization-in-a-trauma-population-a-retrospective-cohort
#39
JOURNAL ARTICLE
Alexander J Chang, Ali F Mallat, Marc J Edwards, Joseph N Gabra, Michaelia D Cucci
PURPOSE: Cannabis utilization has increased over time for recreational and medical purposes due to its legalization or decriminalization. The effects of cannabis use on opioid utilization are not well understood. The primary objective was to evaluate the total opioid utilization, measured in morphine milligram equivalents (MME), in hospitalized trauma patients that tested positive for tetrahydrocannabinol (THC) on a urine drug screen (UDS). METHODS: This was a retrospective, cohort study in a level 1 trauma center between 10/17/17 and 12/31/19...
December 30, 2023: Injury
https://read.qxmd.com/read/38215858/marijuana-and-endoscopy-the-effects-of-marijuana-on-sedation
#40
JOURNAL ARTICLE
Justin Kosirog, Christopher Bouvette, Jiteshwar Pannu, Jalal Gondal, Mohammad Madhoun
BACKGROUND AND AIMS: Marijuana usage has increased significantly as it has become more readily available and legal, either recreationally or medicinally, in many states. It has been postulated that marijuana usage increases the amount of sedation required for procedures. However, there is minimal data defining this relationship. We aim to establish the relationship between marijuana usage and the amount of sedation used during endoscopy. METHODS: This was a single institution prospective study of patients undergoing outpatient endoscopy (both Monitored Anesthesia Care (MAC) and moderate sedation) at the Oklahoma City Veterans Affairs Medical Center with a total of 976 patients participating...
January 10, 2024: Gastrointestinal Endoscopy
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