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ENDURANCE HYPOXIA

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https://www.readbyqxmd.com/read/28715447/short-term-alteration-of-biotic-and-abiotic-components-of-the-pelagic-system-in-a-shallow-bay-produced-by-a-strong-natural-hypoxia-event
#1
Eduardo Hernández-Miranda, Rodrigo Veas, Valeria Anabalón, Renato A Quiñones
In January 2008 there was an intensive and extensive upwelling event in the southern Humboldt Current System. This event produced an intrusion of water with low dissolved oxygen into Coliumo Bay, which caused massive mortality and the beaching of pelagic and benthic organisms, including zooplankton. During this event, which lasted 3 to 5 days, we studied and evaluated the effect of the hypoxic water in the bay on the abundance of macrozooplankton, nanoplankton and microphytoplankton, the concentration of several nutrients and hydrographic conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28685860/exercise-mediated-modulation-of-autophagy-in-skeletal-muscle
#2
REVIEW
Marcos Martin-Rincon, David Morales-Alamo, Jose A L Calbet
Although exercise exerts multiple beneficial health effects, it may also damage cellular structures. Damaged elements are continuously degraded and its constituents recycled to produce renovated structures through a process called autophagy, which is essential for the adaptation to training. Autophagy is particularly active in skeletal muscle, where it can be evaluated by using specific molecular markers of activation (unc-51-like kinase 1 (ULK1) phosphorylation) and specific proteins indicating increased autophagosome content (increased total LC3, LC3-II, LC3-II/LC3-I ratio)...
July 7, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28665150/association-between-plasma-n-acylethanolamides-and-high-hemoglobin-concentration-in-southern-peruvian-highlanders
#3
Dulce E Alarcón-Yaquetto, Lidia Caballero, Gustavo F Gonzales
Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 00:000-000, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechanisms. Failing to adapt to chronic HA exposure leads to a disease called chronic mountain sickness (CMS) characterized by excessive erythrocytosis (hemoglobin [Hb] ≥19 g/dL for women and ≥21 g/dL for men)...
June 30, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28648907/sulfated-dehydropolymer-of-caffeic-acid-in-vitro-anti-lung-cell-death-activity-and-in-vivo-intervention-in-emphysema-induced-by-vegf-receptor-blockade
#4
Tien M Truong, Hua Li, Sneha Dhapare, Umesh R Desai, Nobert F Voelkel, Masahiro Sakagami
Induced lung cell death and impaired hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) signaling are proposed as a pathobiologic mechanism for alveolar structural destruction and loss in emphysema. We hypothesized that our sulfated dehydropolymer of caffeic acid, CDSO3, exerts anti-cell death activities and therapeutic interventions in emphysema by virtue of Fe(2+) chelation-based HIF-1α/VEGF stabilization and elevation. The Fe(2+) chelating activity was determined in the chromogenic ferrozine-Fe(2+) chelation inhibitory assay...
June 22, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28626339/effects-of-2-week-intermittent-training-in-hypobaric-hypoxia-on-the-aerobic-energy-metabolism-and-performance-of-cycling-athletes-with-disabilities
#5
Sang-Hoon Kim, Ho-Jung An, Jung-Hyun Choi, Yong-Youn Kim
[Purpose] The present study aimed at examining changes in aerobic energy metabolism and performance in cycling athletes after 2 weeks of intermittent training in a multistep hypobaric hypoxia environment. [Subjects and Methods] We also aimed at using the findings to propose an efficient training program in hypobaric hypoxia for endurance athletes with disabilities. The study participants were three cycling athletes with physical disabilities from the Korean national team (A, B, and C athletes). They underwent complex (repetition, interval, and continued) training with a roller-type cycle in a multistep hypobaric hypoxia environment (simulated altitude, 4,000 m above sea level)...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28575921/endurance-exercise-in-hypoxia-hyperoxia-and-normoxia-mitochondrial-and-global-adaptations
#6
Axel Przyklenk, Boris Gutmann, Thorsten Schiffer, Wildor Hollmann, Heiko K Strueder, Wilhelm Bloch, Andreas Mierau, Sebastian Gehlert
We hypothesized short-term endurance exercise (EN) in hypoxia (HY) to exert decreased mitochondrial adaptation, peak oxygen consumption (VO2peak) and peak power output (PPO) compared to EN in normoxia (NOR) and hyperoxia (PER). 11 male subjects performed repeated unipedal cycling EN in HY, PER, and NOR over 4 weeks in a cross-over design. VO2peak, PPO, rate of perceived exertion (RPE) and blood lactate (Bla) were determined pre- and post-intervention to assess physiological demands and adaptation. Skeletal muscle biopsies were collected to determine molecular mitochondrial signaling and adaptation...
July 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28523996/micro-rnas-exercise-and-cellular-plasticity-in-humans-the-impact-of-dietary-factors-and-hypoxia
#7
Timothée Watier, Anthony Mj Sanchez
Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28522767/individual-hemoglobin-mass-response-to-normobaric-and-hypobaric-live-high-train-low-a-one-year-crossover-study
#8
Anna Hauser, Severin Troesch, Jonas J Saugy, Laurent Schmitt, Roberto Cejuela-Anta, Raphael Faiss, Thomas Steiner, Neil Robinson, Grégoire P Millet, Jon Peter Wehrlin
PURPOSE: To compare individual hemoglobin mass (Hbmass) changes following a live high-train low (LHTL) altitude training camp under either normobaric hypoxia (NH) or hypobaric hypoxia (HH) conditions in endurance athletes. METHODS: In a crossover design with a one-year washout, 15 male triathletes randomly performed two 18-d LHTL training camps in either HH or NH. All athletes slept at 2250 m and trained at altitudes < 1200 m. Hbmass was measured in duplicate with the optimized carbon monoxide rebreathing method before (pre-) and immediately after (post-) each 18 d training camp...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28467859/the-novel-combination-of-theophylline-and-bambuterol-as-a-potential-treatment-of-hypoxemia-in-humans
#9
Trond-Eirik Strand, Hasse Khiabani-Zare, Alina Boico, Daniel R Radiloff, Yulin Zhao, Karyn Hamilton, Uwe Christians, Jelena Klawitter, Robert J Noveck, Claude A Piantadosi, Christopher Bell, David C Irwin, Thies Schroeder
Hypoxemia can be life-threatening both, acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to tissue, it can be pharmacologically addressed. We hypothesized that theophylline can be safely combined with the β2 adrenergic vasodilator bambuterol to improve oxygen availability in hypoxemic patients. Ergogenicity and hemodynamic effects of bambuterol and theophylline were measured in rats under hypobaric and normobaric hypoxia (12% O2). Feasibility in humans was assessed using randomized, double-blind testing of the influence of combined slow-release theophylline (300 mg) and bambuterol (20mg) on adverse events (AEs), plasma K+, pulse, blood pressure, and drug interaction...
May 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28413958/anti-fatigue-effects-of-active-ingredients-from-traditional-chinese-medicine-a-review
#10
Si-Si Zhou, Jian-Guo Jiang
Fatigue, a phenomenon which is believed to be caused by body exercise, can lead to the failure of predetermined exercise intensity maintenance and sport ability declination. The usage of traditional Chinese medicine (TCM) in the treatment of fatigue has long been practiced in clinical and showed significant effects. This article covers related literatures in recent years and sorts the effective ingredients from TCM for treating fatigue into a few categories including alkaloids, saponins, polysaccharides, polyphenols, polypeptide, terpene, proteins and other active ingredients...
April 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28394459/ergogenic-properties-of-metformin-in-simulated-high-altitude
#11
Rebecca L Scalzo, Hunter L Paris, Scott E Binns, Janelle L Davis, Joseph W Beals, Christopher L Melby, Gary J Luckasen, Matthew S Hickey, Benjamin F Miller, Karyn L Hamilton, Christopher Bell
Metformin augments glucose/glycogen regulation and may acutely promote fatigue resistance during high-intensity exercise. In hypobaric environments, such as high altitude, the important contribution of carbohydrates to physiological function is accentuated as glucose/glycogen dependence is increased. Because hypoxia/hypobaria decreases insulin sensitivity, replenishing skeletal muscle glycogen in high altitude becomes challenging and subsequent physical performance may be compromised. We hypothesized that in conditions where glycogen repletion was critical to physical outcomes, metformin would attenuate hypoxia-mediated decrements in exercise performance...
April 10, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28368957/impact-of-endurance-exercise-in-hypoxia-on-muscle-damage-inflammatory-and-performance-responses
#12
Daichi Sumi, Chihiro Kojima, Kazushige Goto
This study evaluated muscle damage and inflammatory and performance responses following high-intensity endurance exercise in moderate hypoxia among endurance athletes. Nine trained endurance athletes completed two different trials on different days: exercise under moderate hypoxia (H trial, FiO2 = 14.5%) and normoxia (N trial, FiO2 = 20.9%). They performed interval exercises (10 × 3-min running at 95% of VO2max with 60-s of active rest at 60% of VO2max) followed by 30-min of continuous running at 85% of VO2max under either hypoxic or normoxic conditions...
March 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28362866/thoraco-abdominal-coordination-and-performance-during-uphill-running-at-altitude
#13
Eva Bernardi, Lorenza Pratali, Gaia Mandolesi, Maria Spiridonova, Giulio Sergio Roi, Annalisa Cogo
INTRODUCTION: Running races on mountain trails at moderate-high altitude with large elevation changes throughout has become increasingly popular. During exercise at altitude, ventilatory demands increase due to the combined effects of exercise and hypoxia. AIM: To investigate the relationships between thoraco-abdominal coordination, ventilatory pattern, oxygen saturation (SpO2), and endurance performance in runners during high-intensity uphill exercise. METHODS: Fifteen participants (13 males, mean age 42±9 yrs) ran a "Vertical Kilometer," i...
2017: PloS One
https://www.readbyqxmd.com/read/28351494/perfusion-computed-tomography-imaging-of-abdominal-aortic-aneurysms-may-be-of-value-for-patient-specific-rupture-risk-estimation
#14
Nikolaos Kontopodis, Nikolaos Galanakis, Dimitrios Tsetis, Christos V Ioannou
Abdominal aortic aneurysm (AAA) continues to pose a significant cause of unexpected mortality in the developed countries with its incidence constantly rising. The indication of elective surgical repair is currently based on the maximum diameter and growth rate criteria which represent an oversimplification of the Law of Laplace stating that the stress exerted in a cylinder or sphere is proportional to its radius. These criteria fail to capture the complex pathophysiology of the aneurismal disease thus often leading to therapeutic inaccuracies (treating large AAAs with a very low actual rupture risk while observing smaller ones with a much greater risk)...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351441/-oxygen-therapy-not-required-for-all-copd-patients
#15
L E G W Vanfleteren
Long-term oxygen therapy in patients with pronounced hypoxia is an important and life-extending therapy. Many patients have only mild hypoxia, do not experience nocturnal desaturation, or experience desaturation only during exercise. While often applied in clinical practice, the clinical relevance of oxygen therapy was not clear in these patients. A recent randomized controlled trial has now revealed no additional value for long-term oxygen therapy in subjects with mild oxygen desaturation or exercise-induced oxygen desaturation only...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28332025/endurance-aerobic-high-intensity-and-repeated-sprint-cycling-performance-is-unaffected-by-normobaric-live-high-train-low-a-double-blind-placebo-controlled-cross-over-study
#16
RANDOMIZED CONTROLLED TRIAL
Jacob Bejder, Andreas Breenfeldt Andersen, Rie Buchardt, Tanja Hultengren Larsson, Niels Vidiendal Olsen, Nikolai Baastrup Nordsborg
The aim was to investigate whether 6 weeks of normobaric "Live High-Train Low" (LHTL) using altitude tents affect highly trained athletes incremental peak power, 26-km time-trial cycling performance, 3-min all-out performance, and 30-s repeated sprint ability. In a double-blinded, placebo-controlled cross-over design, seven highly trained triathletes were exposed to 6 weeks of normobaric hypoxia (LHTL) and normoxia (placebo) for 8 h/day. LHTL exposure consisted of 2 weeks at 2500 m, 2 weeks at 3000 m, and 2 weeks at 3500 m...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28326844/oxidative-stress-in-acute-hypobaric-hypoxia
#17
Sebastián Irarrázaval, Claudio Allard, Juan Campodónico, Druso Pérez, Pablo Strobel, Luis Vásquez, Inés Urquiaga, Guadalupe Echeverría, Federico Leighton
Irarrázaval, Sebastián, Claudio Allard, Juan Campodónico, Druso Pérez, Pablo Strobel, Luis Vásquez, Inés Urquiaga, Guadalupe Echeverría, and Federico Leighton. Oxidative stress in acute hypobaric hypoxia. High Alt Med Biol. 00:000-000, 2017.-The effects of acute hypobaric hypoxia endured by mountaineers were studied, specifically as evidenced by acute mountain sickness (AMS) and oxidative stress damage. Ten male volunteers were exposed to acute hypobaric hypoxia, and AMS was evaluated through arterial oxygen saturation (SaO2), cardiac rate, and the Lake Louise Score (LLS)...
March 22, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28261888/endurance-performance-in-well-trained-mice-is-enhanced-by-short-duration-intermittent-hypoxia-via-improved-muscle-fatty-acid-metabolism
#18
Junichi Suzuki
The author previously reported that short-duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short-duration intermittent hypoxia on endurance capacity in well-trained mice. Mice in the training group were housed in a cage with a wheel activity device for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal exercise capacity (by 5.9-fold). Trained mice were then subjected to either normoxic treadmill training (Tr) or training with short-duration intermittent hypoxia (12% O2 for 15 min, 20...
March 5, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28223938/hypoxic-repeat-sprint-training-improves-rugby-player-s-repeated-sprint-but-not-endurance-performance
#19
Michael J Hamlin, Peter D Olsen, Helen C Marshall, Catherine A Lizamore, Catherine A Elliot
This study aims to investigate the performance changes in 19 well-trained male rugby players after repeat-sprint training (six sessions of four sets of 5 × 5 s sprints with 25 s and 5 min of active recovery between reps and sets, respectively) in either normobaric hypoxia (HYP; n = 9; FIO2 = 14.5%) or normobaric normoxia (NORM; n = 10; FIO2 = 20.9%). Three weeks after the intervention, 2 additional repeat-sprint training sessions in hypoxia (FIO2 = 14.5%) was investigated in both groups to gauge the efficacy of using "top-up" sessions for previously hypoxic-trained subjects and whether a small hypoxic dose would be beneficial for the previously normoxic-trained group...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28209739/myocardial-ischemic-tolerance-in-rats-subjected-to-endurance-exercise-training-during-adaptation-to-chronic-hypoxia
#20
Petra Alánová, Anna Chytilová, Jan Neckář, Jaroslav Hrdlička, Petra Míčová, Kristýna Holzerová, Markéta Hlaváčková, Kristýna Macháčková, František Papoušek, Jana Vašinová, Daniel Benák, Olga Nováková, František Kolář
Chronic hypoxia and exercise are natural stimuli that confer sustainable cardioprotection against ischemia-reperfusion (I/R) injury, but it is unknown whether they can act in synergy to enhance ischemic resistance. Inflammatory response mediated by tumor necrosis factor-α (TNF-α) plays a role in the infarct size limitation by continuous normobaric hypoxia (CNH), whereas exercise is associated with anti-inflammatory effects. This study was conducted to determine if exercise training performed under conditions of CNH (12% O2) affects myocardial ischemic resistance with respect to inflammatory and redox status...
June 1, 2017: Journal of Applied Physiology
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