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ENDURANCE HYPOXIA

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https://www.readbyqxmd.com/read/28223938/hypoxic-repeat-sprint-training-improves-rugby-player-s-repeated-sprint-but-not-endurance-performance
#1
Michael J Hamlin, Peter D Olsen, Helen C Marshall, Catherine A Lizamore, Catherine A Elliot
This study aims to investigate the performance changes in 19 well-trained male rugby players after repeat-sprint training (six sessions of four sets of 5 × 5 s sprints with 25 s and 5 min of active recovery between reps and sets, respectively) in either normobaric hypoxia (HYP; n = 9; FIO2 = 14.5%) or normobaric normoxia (NORM; n = 10; FIO2 = 20.9%). Three weeks after the intervention, 2 additional repeat-sprint training sessions in hypoxia (FIO2 = 14.5%) was investigated in both groups to gauge the efficacy of using "top-up" sessions for previously hypoxic-trained subjects and whether a small hypoxic dose would be beneficial for the previously normoxic-trained group...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28209739/myocardial-ischemic-tolerance-in-rats-subjected-to-endurance-exercise-training-during-adaptation-to-chronic-hypoxia
#2
Petra Alánová, Anna Chytilová, Jan Neckář, Jaroslav Hrdlička, Petra Míčová, Kristýna Holzerová, Markéta Hlaváčková, Kristýna Macháčková, František Papoušek, Jana Vašinová, Daniel Benák, Olga Nováková, František Kolář
Chronic hypoxia and exercise are natural stimuli that confer sustainable cardioprotection against ischemia/reperfusion (I/R) injury but it is unknown whether they can act in synergy to enhance ischemic resistance. Inflammatory response mediated by tumor necrosis factor-α (TNF-α) plays a role in the infarct size-limitation by continuous normobaric hypoxia (CNH) whereas exercise is associated with anti-inflammatory effects. This study was conducted to determine whether exercise training performed under conditions of CNH (12% O2) affects myocardial ischemic resistance with respect to inflammatory and redox status...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28149350/the-influence-of-high-altitude-acclimatization-on-ventilatory-and-blood-oxygen-saturation-responses-during-normoxic-and-hypoxic-testing
#3
Anton Ušaj, Stojan Burnik
We investigated how acclimatization effects achieved during a high-altitude alpinist expedition influence endurance performance, ventilation ([Formula: see text]) and blood oxygen saturation (SaO2) in normoxic (NOR) and hypoxic conditions (HYP). An incremental testing protocol on a cycle ergometer was used to determine the power output corresponding to the Lactate (PLT) and Ventilatory Threshold (PVT) in NOR and HYP (FiO2=0.13) as indirect characteristics of endurance performance in both conditions. Furthermore, changes in [Formula: see text], SaO2, blood pH and Pco2 were measured at a similar absolute exercise intensity of 180 W in NOR and HYP conditions...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28135217/short-term-hypoxic-exposure-and-training-improve-maximal-anaerobic-running-test-performance
#4
Marie Oriishi, Takeo Matsubayashi, Takashi Kawahara, Yasuhiro Suzuki
The purpose of this study was to examine the effectiveness of short-term hypoxic exposure and training in the performance of competitive 400 m or 800 m runners. Fifteen female competitive 400 m and 800 m runners volunteered to participate and were assigned to either the hypoxic (n = 7) or normoxic (n = 8) group. The subjects completed 6 days of training. The hypoxic group trained and slept in normobaric hypoxia, with oxygen concentrations of 14.4% and 16.5% for training and sleep, respectively. The normoxic group trained and slept at sea level...
January 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28124127/acute-low-intensity-cycling-with-blood-flow-restriction-has-no-effect-on-metabolic-signaling-in-human-skeletal-muscle-compared-to-traditional-exercise
#5
William J Smiles, Miguel S Conceição, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Felipe C Vechin, Cleiton A Libardi, John A Hawley, Donny M Camera
PURPOSE: Autophagy is an intracellular degradative system sensitive to hypoxia and exercise-induced perturbations to cellular bioenergetics. We determined the effects of low-intensity endurance-based exercise performed with blood-flow restriction (BFR) on cell signaling adaptive responses regulating autophagy and substrate metabolism in human skeletal muscle. METHODS: In a randomized cross-over design, nine young, healthy but physically inactive males completed three experimental trials separated by 1 week of recovery consisting of either a resistance exercise bout (REX: 4 × 10 leg press repetitions, 70% 1-RM), endurance exercise (END: 30 min cycling, 70% VO2peak), or low-intensity cycling with BFR (15 min, 40% VO2peak)...
January 25, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28067808/effects-of-beetroot-juice-supplementation-on-cardiorespiratory-endurance-in-athletes-a-systematic-review
#6
REVIEW
Raúl Domínguez, Eduardo Cuenca, José Luis Maté-Muñoz, Pablo García-Fernández, Noemí Serra-Paya, María Carmen Lozano Estevan, Pablo Veiga Herreros, Manuel Vicente Garnacho-Castaño
Athletes use nutritional supplementation to enhance the effects of training and achieve improvements in their athletic performance. Beetroot juice increases levels of nitric oxide (NO), which serves multiple functions related to increased blood flow, gas exchange, mitochondrial biogenesis and efficiency, and strengthening of muscle contraction. These biomarker improvements indicate that supplementation with beetroot juice could have ergogenic effects on cardiorespiratory endurance that would benefit athletic performance...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28039190/endurance-training-attenuates-the-increase-in-peripheral-chemoreflex-sensitivity-with-intermittent-hypoxia
#7
Amanda J Miller, Charity L Sauder, Aimee E Cauffman, Cheryl A Blaha, Urs A Leuenberger
Patients with heart failure and sleep apnea have greater chemoreflex sensitivity, presumably due to intermittent hypoxia (IH), and this is predictive of mortality. We hypothesized that endurance training would attenuate the effect of IH on peripheral chemoreflex sensitivity in healthy humans. Fifteen young healthy subjects (9 female, 26 ± 1 yr) participated. Between visits, 11 subjects underwent 8 wk of endurance training that included running four times/wk at 80% predicted maximum heart rate and interval training, and four control subjects did not change activity...
February 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28018235/modulation-of-muscle-fiber-compositions-in-response-to-hypoxia-via-pyruvate-dehydrogenase-kinase-1
#8
Daniel D Nguyen, Gyuyoup Kim, Eung-Kwon Pae
Muscle fiber-type changes in hypoxic conditions in accordance with pyruvate dehydrogenase kinase (Pdk)-1 and hypoxia inducible factor (Hif)-1α were investigated in rats. Hif-1α and its down-stream molecule Pdk-1 are well known for readily response to hypoxia. We questioned their roles in relation to changes in myosin heavy chain (MyHC) composition in skeletal muscles. We hypothesize that the level of Pdk-1 with respect to the level of Hif-1α determines MyHC composition of the muscle in rats in hypoxia. Young male rats were housed in a chamber maintained at 11...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27721912/effect-of-high-intensity-training-in-normobaric-hypoxia-on-thoroughbred-skeletal-muscle
#9
Hiroshi Nagahisa, Kazutaka Mukai, Hajime Ohmura, Toshiyuki Takahashi, Hirofumi Miyata
Hypoxic training is believed to increase endurance capacity in association with hypoxia inducible factor-1α (HIF-1α), a modulator of vascular endothelial growth factor-A (VEGF-A), and to influence activation of satellite cells (SCs). However, the effect of hypoxic training on SC activation and its relation to angiogenesis has not been thoroughly investigated. Eight Thoroughbred horses were subjected to normoxic (FIO2 = 21%) or hypoxic (FIO2 = 15%) training for 3 days/week (100%  [Formula: see text]) for 4 weeks...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27710149/heightened-exercise-induced-oxidative-stress-at-simulated-moderate-level-altitude-vs-sea-level-in-trained-cyclists
#10
Alex J Wadley, Ida S Svendsen, Michael Gleeson
Altitude exposure can exaggerate the transient increase in markers of oxidative stress observed following acute exercise. However, these responses have not been monitored in endurance-trained cyclists at altitudes typically experienced whilst training. Endurance trained males (n=12; mean (±SD) age: 28 ± 4 years, V̇O2max 63.7 ± 5.3 ml/kg/min) undertook two 75-min exercise trials at 70% relative V̇O2max; once in normoxia and once in hypobaric hypoxia, equivalent to 2000m above sea level (hypoxia). Blood samples were collected before, immediately after and 2 h post-exercise to assess plasma parameters of oxidative stress (protein carbonylation (PC), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) and catalase activity (CAT))...
October 6, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27660299/generation-of-active-expiration-by-serotoninergic-mechanisms-of-the-ventral-medulla-of-rats
#11
Eduardo V Lemes, Eduardo Colombari, Daniel B Zoccal
Abdominal expiratory activity is absent at rest and is evoked during metabolic challenges, such as hypercapnia and hypoxia, or after the exposure to intermittent hypoxia (IH). The mechanisms engaged during this process are not completely understood. In this study, we hypothesized that serotonin (5-HT), acting in the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG), is able to generate active expiration. In anesthetized (urethane, ip), tracheostomized, spontaneously-breathing adult male Holtzman rats we microinjected a serotoninergic agonist and antagonist bilaterally in the RTN/pFRG and recorded diaphragm and abdominal muscle activities...
November 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27634605/respiratory-muscle-training-and-exercise-endurance-at-altitude
#12
Samuel Helfer, Joseph Quackenbush, Michael Fletcher, David R Pendergast
BACKGROUND: Climbing and trekking at altitude are common recreational and military activities. Physiological effects of altitude are hypoxia and hyperventilation. The hyperventilatory response to altitude may cause respiratory muscle fatigue and reduce sustained submaximal exercise. Voluntary isocapnic hyperpnea respiratory muscle training (VIHT) improves exercise endurance at sea level and at depth. The purpose of this study was to test the hypothesis that VIHT would improve exercise time at altitude [3600 m (11,811 ft)] compared to control and placebo groups...
August 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27590526/adaptive-patterns-in-the-p53-protein-sequence-of-the-hypoxia-and-cancer-tolerant-blind-mole-rat-spalax
#13
Vered Domankevich, Yarden Opatowsky, Assaf Malik, Abraham B Korol, Zeev Frenkel, Irena Manov, Aaron Avivi, Imad Shams
BACKGROUND: The subterranean blind mole rat, Spalax (genus Nannospalax) endures extreme hypoxic conditions and fluctuations in oxygen levels that threaten DNA integrity. Nevertheless, Spalax is long-lived, does not develop spontaneous cancer, and exhibits an outstanding resistance to carcinogenesis in vivo, as well as anti-cancer capabilities in vitro. We hypothesized that adaptations to similar extreme environmental conditions involve common mechanisms for overcoming stress-induced DNA damage...
2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27475952/the-impact-of-hyperoxia-on-human-performance-and-recovery
#14
REVIEW
Billy Sperlich, Christoph Zinner, Anna Hauser, Hans-Christer Holmberg, Jennifer Wegrzyk
Hyperoxia results from the inhalation of mixtures of gas containing higher partial pressures of oxygen (O2) than normal air at sea level. Exercise in hyperoxia affects the cardiorespiratory, neural and hormonal systems, as well as energy metabolism in humans. In contrast to short-term exposure to hypoxia (i.e. a reduced partial pressure of oxygen), acute hyperoxia may enhance endurance and sprint interval performance by accelerating recovery processes. This narrative literature review, covering 89 studies published between 1975 and 2016, identifies the acute ergogenic effects and health concerns associated with hyperoxia during exercise; however, long-term adaptation to hyperoxia and exercise remain inconclusive...
July 30, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27462274/effects-of-gestational-and-postnatal-exposure-to-chronic-intermittent-hypoxia-on-diaphragm-muscle-contractile-function-in-the-rat
#15
Fiona B McDonald, Eugene M Dempsey, Ken D O'Halloran
Alterations to the supply of oxygen during early life presents a profound stressor to physiological systems with aberrant remodeling that is often long-lasting. Chronic intermittent hypoxia (CIH) is a feature of apnea of prematurity, chronic lung disease, and sleep apnea. CIH affects respiratory control but there is a dearth of information concerning the effects of CIH on respiratory muscles, including the diaphragm-the major pump muscle of breathing. We investigated the effects of exposure to gestational CIH (gCIH) and postnatal CIH (pCIH) on diaphragm muscle function in male and female rats...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27406142/ischaemic-preconditioning-does-not-alter-the-determinants-of-endurance-running-performance-in-the-heat
#16
Carl A James, Ashley G B Willmott, Alan J Richardson, Peter W Watt, Neil S Maxwell
PURPOSE: Ischaemic preconditioning (IP) has been shown to be ergogenic for endurance performance in normothermic conditions and alleviate physiological strain under hypoxia, potentially through haemodynamic and/or metabolic mechanisms. Exertional hyperthermia is characterised by competition for blood flow between the muscles and skin, an enhanced metabolic strain and impaired endurance performance. This study investigated the effect of IP on the determinants of endurance performance, through an incremental exercise test in the heat...
September 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27393382/activation-of-the-hypoxia-inducible-factor-pathway-induced-by-prolyl-hydroxylase-domain-2-deficiency-enhances-the-effect-of-running-training-in-mice
#17
Aki Nunomiya, Junchul Shin, Yasuo Kitajima, Takashi Dan, Toshio Miyata, Ryoichi Nagatomi
AIMS: Hypoxic response mediated by hypoxia-inducible factor (HIF) seems to contribute to the benefit of endurance training. To verify the direct contribution of HIF activation to running training without exposure to atmospheric hypoxia, we used prolyl hydroxylase domain 2 (PHD2) conditional knockout mice (cKO), which exhibit HIF activation independent of oxygen concentration, and we examined their maximal exercise capacity before and after 4 weeks of treadmill exercise training. METHODS: Phd2(f/f) mice (n = 26) and Phd2 cKO mice (n = 24) were randomly divided into two groups, trained and untrained, and were subjected to maximal running test before and after a 4-week treadmill-training regimen...
July 9, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27378942/nitrate-intake-promotes-shift-in-muscle-fiber-type-composition-during-sprint-interval-training-in-hypoxia
#18
Stefan De Smet, Ruud Van Thienen, Louise Deldicque, Ruth James, Craig Sale, David J Bishop, Peter Hespel
PURPOSE: We investigated the effect of sprint interval training (SIT) in normoxia, vs. SIT in hypoxia alone or in conjunction with oral nitrate intake, on buffering capacity of homogenized muscle (βhm) and fiber type distribution, as well as on sprint and endurance performance. METHODS: Twenty-seven moderately-trained participants were allocated to one of three experimental groups: SIT in normoxia (20.9% FiO2) + placebo (N), SIT in hypoxia (15% FiO2) + placebo (H), or SIT in hypoxia + nitrate supplementation (HN)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27362575/adipose-derived-stem-cells-sustain-prolonged-angiogenesis-through-leptin-secretion
#19
Simona Delle Monache, Alessia Calgani, Patrizia Sanità, Francesca Zazzeroni, Emilio Gentile Warschauer, Antonio Giuliani, Gianfranco Amicucci, Adriano Angelucci
Recent studies suggest that adipose-derived stem cells (ASCs) play a role in tissue remodeling through the release of cytokines and growth factors. We compared the secreted cytokine profile of hypoxia-conditioned ASCs (hASCs) with normoxic ASCs (nASCs) and we analyzed the effect of ASCs conditioned medium (CM) on endothelial cells. We found that hypoxia induced a transient upregulation of VEGF in ASCs and a notable and enduring upregulation of leptin mRNA expression 30-fold greater than control after 24 h and up to 60-fold greater than control at day 7...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27360864/impact-of-endurance-exercise-in-hypoxia-on-metabolic-and-muscle-damage-response-and-performance-recovery-2039-board-191-june-2-3-30-pm-5-00-pm
#20
Daichi Sumi, Chihiro Kojima, Kazushige Goto
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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