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Gastroparesis

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https://www.readbyqxmd.com/read/27916055/-pathogenesis-of-gastroparesis
#1
G Bai, H H Wang
No abstract text is available yet for this article.
December 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27914942/is-there-a-role-for-ghrelin-in-central-dopaminergic-systems-focus-on-nigrostriatal-and-mesocorticolimbic-pathways
#2
REVIEW
Alicia Stievenard, Mathieu Méquinion, Zane B Andrews, Alain Destée, Marie-Christine Chartier-Harlin, Odile Viltart, Christel C Vanbesien-Mailliot
The gastro-intestinal peptide ghrelin has been assigned many functions. These include appetite regulation, energy metabolism, glucose homeostasis, intestinal motility, anxiety, memory or neuroprotection. In the last decade, this pleiotropic peptide has been proposed as a therapeutic agent in gastroparesis for diabetes and in cachexia for cancer. Ghrelin and its receptor, which is expressed throughout the brain, play an important role in motivation and reward. Ghrelin finely modulates the mesencephalic dopaminergic signaling and is thus currently studied in pathological conditions including dopamine-related disorders...
November 30, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27896652/the-long-term-efficacy-and-safety-of-pyloroplasty-combined-with-gastric-electrical-stimulation-therapy-in-gastroparesis
#3
Brian R Davis, Irene Sarosiek, Mohammad Bashashati, Ben Alvarado, Richard W McCallum
INTRODUCTION: Gastroparesis is delayed gastric emptying without mechanical obstruction. Symptomatic improvement can be 50-60% with gastric electrical stimulation. To address delayed gastric emptying, pyloroplasty was added. This study examines the long-term efficacy and safety of simultaneous gastric electrical stimulator implantation and pyloroplasty. METHODS: In this prospective single-arm trial conducted from 2012 to 2015, 27 [23 females; mean age 43 (22-63)] gastroparesis patients who underwent simultaneous gastric electrical stimulator implantation with Heineke-Mikulicz pyloroplasty were studied...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27888862/functional-and-motor-gastrointestinal-disorders
#4
Fermín Mearin, Enrique Rey, Agustín Balboa
This article discusses the most interesting presentations at Digestive Disease Week, held in San Diego, in the field of functional and motor gastrointestinal disorders. One of the most important contributions was undoubtedly the presentation of the new Rome IV diagnostic criteria for functional gastrointestinal disorders. We therefore devote some space in this article to explaining these new criteria in the most common functional disorders. In fact, there has already been discussion of data comparing Rome IV and Rome III criteria in the diagnosis of irritable bowel syndrome, confirming that the new criteria are somewhat more restrictive...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27882650/a-qualitative-assessment-of-west-virginia-pharmacist-activities-and-attitude-in-diabetes-management
#5
Aymen Shatnawi, David A Latif
AIMS AND OBJECTIVES: The role of pharmacists in chronic disease state management has been shown to significantly improve patient health outcomes and reduce overall health care costs. The current study is designed to assess the roles and attitudes of West Virginia (WV) pharmacists toward diabetes, evaluate services provided, address pharmacist clinical understanding and training, and demonstrate the challenges that limit pharmacists ability to deliver an efficient disease state management...
November 24, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27869566/gastrointestinal-comorbidities-which-complicate-the-treatment-of-anorexia-nervosa
#6
Margherita Mascolo, Bashir Geer, Joshua Feuerstein, Philip S Mehler
Patients with anorexia nervosa often voice a multitude of symptoms in regards to their gastrointestinal tract. These complaints can complicate the treatment of their eating disorder as they distract attention from the important goal of weight restoration. Moreover, the restricting of certain food groups also makes the task of weight restoration substantially more difficult, or may result in binging. Therefore a working knowledge of common gastrointestinal comorbidities, such as celiac disease, irritable bowel syndrome, inflammatory bowel disease, and gastroparesis, is useful when treating a patient who has anorexia nervosa...
November 21, 2016: Eating Disorders
https://www.readbyqxmd.com/read/27820956/the-association-between-fasting-c-peptide-and-gastrointestinal-symptoms-of-gastroparesis-in-type-2-diabetic-patients
#7
Yun Huang, Honghong Zhang, Minxia Zhang, Wenya Li, Jinhua Wang, Ji Hu
Background/Aims: The relationship between c-peptide levels and gastrointestinal (GI) symptoms in type 2 diabetic patients is not clear. The purpose of this study is to examine the association between fasting C-peptide and GI symptoms of gastroparesis in type 2 diabetic patients. Methods: We recruited 333 type 2 diabetic patients into the present study. All the patients filled out questionnaires of gastroparesis cardinal symptom index (GCSI) to evaluate GI symptoms...
November 7, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27807571/pancreatic-adenocarcinoma-invading-the-duodenum-and-presenting-as-idiopathic-gastroparesis-with-nausea-and-vomiting
#8
Brent T Cengia, Paula S Stuart, Kenneth L Koch
A 65-year-old woman presented with a 5-month history of nausea, vomiting, and weight loss. Prior esophagogastrodudenoscopy showed retained food and delayed gastric emptying, but abdominal computed tomography was normal. The working diagnosis was idiopathic gastroparesis. Subsequently, an electrogastrogram test showed normal 3-cycle-per-minute activity, although it was suggestive of obstructive gastroparesis. Repeat esophagogastrodudenoscopy showed obstruction at the postbulbar duodenum. Repeat abdominal computed tomography revealed a 2...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27796517/gastric-motility-and-emptying-assessment-by-magnetic-resonance-imaging-after-lung-transplantation-correlation-with-gastric-emptying-scintigraphy
#9
Nobuyuki Hayakawa, Yuji Nakamoto, Toyofumi F Chen-Yoshikawa, Aki Kido, Takayoshi Ishimori, Koji Fujimoto, Tetsu Yamada, Masaaki Sato, Akihiro Aoyama, Hiroshi Date, Kaori Togashi
PURPOSE: Gastroparesis is a frequent gastrointestinal complication after lung transplantation. Although gastric emptying scintigraphy (GES) is the standard technique to evaluate gastroparesis, magnetic resonance imaging (MRI) can also assess gastric motility and emptying. This study compared the results obtained by these two modalities. METHODS: Twenty-two lung transplant recipients underwent MRI and GES after ingesting a small pancake as a test meal. Parameters assessed on MRI included antral peristaltic wave velocity and frequency, and the ratios of gastric content volume at 15 and 35 min...
October 31, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27795979/interleukin-10-restores-gastric-emptying-electrical-activity-and%C3%A2-interstitial-cells-of-cajal-networks-in-diabetic-mice
#10
Kyoung Moo Choi, Simon J Gibbons, Lei Sha, Arthur Beyder, Pieter-Jan Verhulst, Gianluca Cipriani, Jessica E Phillips, Anthony J Bauer, Tamas Ordog, Jon J Camp, Xin Ge, Adil E Bharucha, David R Linden, Joseph H Szurszewski, Purna C Kashyap, Gianrico Farrugia
BACKGROUND & AIMS: Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 administration could improve gastric emptying and reverse the associated cellular and electrical abnormalities in diabetic mice...
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27785328/measures-of-autonomic-dysfunction-in-diabetic-and-idiopathic-gastroparesis
#11
Mohammad Khalid Mohammad, Dominique J Pepper, Archana Kedar, Feriyl Bhaijee, Babajide Familoni, Hani Rashed, Teresa Cutts, Thomas L Abell
BACKGROUND: Gastroparesis is a condition classically characterized by delayed gastric emptying and is associated with considerable morbidity. While the etiology of gastroparesis remains elusive, autonomic dysfunction may play an important role, especially as many patients with gastroparesis also have diabetes. The aim of this study was to determine whether measures of autonomic function differ between adults with diabetic gastroparesis (DG) and adults with idiopathic gastroparesis (IG)...
October 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27785323/increased-expression-of-pyloric-er%C3%AE-is-associated-with-diabetic-gastroparesis-in-streptozotocin-induced-male-diabetic-rats
#12
Stephen Crimmins, Rebecca Smiley, Kerry Preston, Amy Yau, Richard Mccallum, Mohammed Showkat Ali
BACKGROUND: Gastroparesis is a significant co-morbidity affecting up to 50% of patients with diabetes and is disproportionately found in women. Prior studies have suggested that loss of interstitial cells of Cajal, hyperglycemia, and nitric oxide dysfunction are potential causes of gastroparesis. Since diabetic gastroparesis affects more women than men, we performed an exploratory study with a diabetic rat model to determine if sex hormone signaling is altered in those where gastroparesis develops...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27785318/autonomic-evaluation-of-patients-with-gastroparesis-and-neurostimulation-comparisons-of-direct-systemic-and-indirect-cardiac-measures
#13
Abigail Stocker, Thomas L Abell, Hani Rashed, Archana Kedar, Ben Boatright, Jiande Chen
BACKGROUND: Disorders of nausea, vomiting, abdominal pain, and related problems often are manifestations of gastrointestinal, neuromuscular, and/or autonomic dysfunction. Many of these patients respond to neurostimulation, either gastric electrical stimulation or electroacupuncture. Both of these therapeutic techniques appear to influence the autonomic nervous system which can be evaluated directly by traditional testing and indirectly by heart rate variability. METHODS: We studied patients undergoing gastric neuromodulation by both systemic autonomic testing (39 patients, six males and 33 females, mean age 38 years) and systemic autonomic testing and heart rate variability (35 patients, seven males and 28 females, mean age 37 years) testing before and after gastric neuromodulation...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27781342/early-satiety-and-postprandial-fullness-in-gastroparesis-correlate-with-gastroparesis-severity-gastric-emptying-and-water-load-testing
#14
H P Parkman, E K Hallinan, W L Hasler, G Farrugia, K L Koch, L Nguyen, W J Snape, T L Abell, R W McCallum, I Sarosiek, P J Pasricha, J Clarke, L Miriel, J Tonascia, F Hamilton
BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2)...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27781339/tumor-necrosis-factor-alpha-derived-from-classically-activated-m1-macrophages-reduces-interstitial-cell-of-cajal-numbers
#15
S T Eisenman, S J Gibbons, P-J Verhulst, G Cipriani, D Saur, G Farrugia
BACKGROUND: Delayed gastric emptying in diabetic mice and humans is associated with changes in macrophage phenotype and loss of interstitial cells of Cajal (ICC) in the gastric muscle layers. In diabetic mice, classically activated M1 macrophages are associated with delayed gastric emptying, whereas alternatively activated M2 macrophages are associated with normal gastric emptying. This study aimed to determine if secreted factors from M1 macrophages could injure mouse ICC in primary culture...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27775961/gastroparesis-quality-of-life-and-health-care-utilization
#16
Brian E Lacy, Michael D Crowell, Carole Mathis, David Bauer, Leslie J Heinberg
BACKGROUND AND AIMS: Gastroparesis (GP) patients suffer from recurrent symptoms of nausea, vomiting, early satiety, and abdominal pain. The impact of GP on quality of life (QoL), health care utilization and daily activities is not well understood. MATERIALS AND METHODS: Part 1: 398 adult patients (≥18 y) with documented GP (symptoms >6 mo) were surveyed to assess QoL and pain using the Short Form 36 and McGill pain questionnaires. Part 2: 491 adult GP patients were surveyed to evaluate employment status, work and daily activities, medication use, physician visits, diagnostic testing, emergency room visits, and hospitalizations related to their GP symptoms...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27769571/complications-associated-with-radiofrequency-ablation-of-pulmonary-veins
#17
J M Madrid Pérez, P M García Barquín, A J Villanueva Marcos, J I García Bolao, G Bastarrika Alemañ
OBJECTIVE: Radiofrequency ablation is an efficacious alternative in patients with symptomatic atrial fibrillation who do not respond to or are intolerant to at least one class I or class III antiarrhythmic drug. Although radiofrequency ablation is a safe procedure, complications can occur. Depending on the location, these complications can be classified into those that affect the pulmonary veins themselves, cardiac complications, extracardiac intrathoracic complications, remote complications, and those that result from vascular access...
October 18, 2016: Radiología
https://www.readbyqxmd.com/read/27759430/evaluation-of-gastric-blood-supply-in-diabetic-patients-with-gastroparesis-by-contrast-enhanced-ultrasound
#18
Hao-Lin Shen, Shu-Ping Yang, Kang-Jian Wang, Bei-Lei Huang, Wen-Bao Huang, Jin-Zhi Wu, Guo-Rong Lv
OBJECTIVE: Improvement in regional blood flow has been shown to ameliorate diabetic gastroparesis. We compared the gastric blood supply in patients with diabetes with gastroparesis with that in healthy subjects, by using contrast-enhanced ultrasound (CEUS). METHODS: 30 healthy subjects and 40 patients with diabetic gastroparesis were enrolled. The CEUS parameters of greater curvatures of the antrum (GCOA) and lesser curvatures of the antrum (LCOA), including peak intensity (PI) and the area under the curve (AUC), were compared between the two groups...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27741058/yield-of-endoscopy-in-pediatric-gastroparesis
#19
Tara A Altepeter, Stephen Shaffer
OBJECTIVES: To quantify the diagnostic yield of upper endoscopy in children with gastroparesis and to develop a clinical model for gastroparesis using common symptoms and screening blood tests. METHODS: We retrospectively reviewed charts of 196 patients aged 4-18yrs evaluated for gastroparesis between 2009 and 2013. All patients completed a standard solid-phase gastric emptying scan and upper endoscopy within a 12-month period. We analyzed gross and histologic endoscopy findings...
October 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27736891/gastrointestinal-dysfunction-in-patients-with-duchenne-muscular-dystrophy
#20
Christian M Lo Cascio, Oliver Goetze, Tsogyal D Latshang, Sena Bluemel, Thomas Frauenfelder, Konrad E Bloch
BACKGROUND: In adult patients with Duchenne muscular dystrophy (DMD) life-threatening constipation has been reported. Since gastrointestinal function in DMD has not been rigorously studied we investigated objective and subjective manifestations of gastrointestinal disturbances in DMD patients. METHODS: In 33 patients with DMD, age 12-41 years, eating behavior and gastrointestinal symptoms were evaluated by questionnaires. Gastric emptying half time (T1/2) and oro-cecal transit time (OCTT) were evaluated by analyzing 13CO2 exhalation curves after ingestion of 13C labeled test meals...
2016: PloS One
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