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MAOA VNTR sex differences

C Aslund, N Nordquist, E Comasco, J Leppert, L Oreland, K W Nilsson
The present study investigated a possible interaction between a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and childhood maltreatment in the prediction of adolescent male and female delinquency. A cohort of 1,825 high school students, 17-18 years old, completed an anonymous questionnaire during class hours which included questions on childhood maltreatment, sexual abuse, and delinquency. Saliva samples were collected for DNA isolation, and analyzed for the MAOA-VNTR polymorphism. Self-reported maltreatment was a strong risk factor for adolescent delinquent behavior...
March 2011: Behavior Genetics
Kent W Nilsson, Erika Comasco, Cecilia Åslund, Niklas Nordquist, Jerzy Leppert, Lars Oreland
The aim of the present study was to investigate MAOA gene-environment (G*E) interactions in relation to adolescent alcohol consumption. In the county of Västmanland, Sweden, all 17-18-year-old students were asked to complete an anonymous questionnaire and provide a saliva sample during class hours. A total of 2263 students completed the questionnaire (77.4%) and a saliva sample was provided by 2131 participants. Failed MAOA u-variable number of tandem repeats (VNTR) genotype analyses and internal non-responses left 851 boys and 735 girls (total n=1586) to be investigated...
April 2011: Addiction Biology
Seung-Gul Kang, Young-Min Park, Jung-Eun Choi, Se-Won Lim, Heon-Jeong Lee, Seung-Hwan Lee, Yong-Ku Kim, Seung-Hyun Kim, Sung Nam Cho, Leen Kim
OBJECTIVE: This study aimed to investigate whether the monoamine oxidase (MAO) A and B genes are associated with antipsychotic-induced restless legs syndrome (RLS) in schizophrenia. METHODS: We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients and divided the subjects into two groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). Genotyping was performed for the variable number of tandem repeat (VNTR) polymorphism of the MAOA gene and A644G polymorphism of the MAOB gene...
July 2010: Human Psychopharmacology
Hai Tang Qiu, Hua Qing Meng, Cai Song, Mei Hong Xiu, Da Chun Chen, Feng Yan Zhu, Gui Ying Wu, Therese A Kosten, Thomas R Kosten, Xiang Yang Zhang
Monoamine oxidase (MAO) A is a critical enzyme in the catabolism of dopamine. Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder. MAOA gene variation was compared between 234 Chinese schizophrenic patients and 121 healthy controls. Three polymorphic markers of the MAOA gene were analyzed using PCR techniques: two MAOA restriction fragment length polymorphisms (RFLP), -941G/T and -1460C/T, and the variable number tandem repeats (VNTR) in the promoter region...
September 1, 2009: Brain Research
Kazuhiko Nakamura, Yoshimoto Sekine, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Ayyappan Anitha, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Norio Mori
Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis...
May 15, 2009: Neuroscience Letters
Shoko Tsuchimine, Norio Yasui-Furukori, Ayako Kaneda, Manabu Saito, Taku Nakagami, Kimihiko Sato, Sunao Kaneko
It has been reported that personality traits are related to several neurotransmitters. However, the association between personality traits and the central nervous system remains unclear. In the present study, we investigated the relationships between a polymorphism involving a variable number of tandem repeats in the promoter of the monoamine oxidase A (MAOA-VNTR) gene and personality traits, as assessed by the Temperament and Character Inventory (TCI). Promoter VNTRs in the MAOA were genotyped in 558 healthy Japanese individuals...
December 12, 2008: Progress in Neuro-psychopharmacology & Biological Psychiatry
Cathy Spatz Widom, Linda M Brzustowicz
BACKGROUND: Two recent studies with white males have shown that genotypes associated with high levels of monamine oxidase A (MAOA) protect against the impact of childhood maltreatment and adversity on the development of antisocial behavior and conduct disorder. METHODS: Participants in a prospective cohort design study involving court substantiated cases of child abuse and neglect and a matched comparison group were followed up into adulthood and interviewed (N = 802)...
October 1, 2006: Biological Psychiatry
Younger W-Y Yu, Shih-Jen Tsai, Chen-Jee Hong, Tai-Jui Chen, Ming-Chao Chen, Chih-Wei Yang
Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of biogenic amines, may be implicated in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants. To elucidate a genetic predisposition of MDD, we studied a variable-number-tandem-repeat (VNTR) polymorphism in the promoter region of the MAOA gene in a Chinese population of 230 MDD patients and 217 controls. We also examined the association of this polymorphism and antidepressant therapeutic response in the MDD patients who underwent a 4-week fluoxetine treatment...
September 2005: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Aryeh I Herman, Kristi M Kaiss, Rui Ma, John W Philbeck, Asfar Hasan, Humza Dasti, Paolo B DePetrillo
The short allelic variant of the serotonin transporter protein promoter polymorphism (5HTTLPR) appears to influence binge drinking in college students. Both monoamine oxidase type A (MAOA) and the serotonin transporter protein are involved in the processing of serotonin, and allelic variants are both associated with differences in the efficiency of expression. We hypothesized that a significant gene x gene interaction would further stratify the risk of binge drinking in this population. Participants were college students (n = 412) who completed the College Alcohol Study, used to measure binge drinking behaviors...
February 5, 2005: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
M Preisig, F Bellivier, B T Fenton, P Baud, A Berney, P Courtet, P Hardy, J Golaz, M Leboyer, J Mallet, M L Matthey, D Mouthon, E Neidhart, M Nosten-Bertrand, E Stadelmann-Dubuis, J Guimon, F Ferrero, C Buresi, A Malafosse
OBJECTIVE: Although genetic factors have been implicated in the etiology of bipolar disorder, no specific gene has been conclusively identified. Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. METHOD: In France and Switzerland, 272 patients with bipolar disorder and 122 healthy subjects were typed for three polymorphic markers of the MAOA gene: the MAOA-CA repeat, the MAOA restriction fragment length polymorphism (RFLP), and a repeat directly adjacent to the variable number of tandem repeats (VNTR) locus...
June 2000: American Journal of Psychiatry
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